Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
HIF-1-alpha transcription factor network	194.0	14818.0	76.0	-1.331	0.026	1000.0	-1000.0	-0.164	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	187.0	6365.0	34.0	-0.623	0.016	1000.0	-1000.0	-0.082	-1000.0
TCR signaling in naïve CD8+ T cells	136.0	12666.0	93.0	-0.672	0.334	1000.0	-1000.0	-0.12	-1000.0
TCGA08_p53	132.0	927.0	7.0	-0.656	0.314	1000.0	-1000.0	-0.022	-1000.0
FOXA2 and FOXA3 transcription factor networks	114.0	5248.0	46.0	-1.26	0.025	1000.0	-1000.0	-0.085	-1000.0
Syndecan-4-mediated signaling events	110.0	7420.0	67.0	-0.65	0.11	1000.0	-1000.0	-0.13	-1000.0
Aurora B signaling	110.0	7416.0	67.0	-0.417	0.016	1000.0	-1000.0	-0.098	-1000.0
IL12-mediated signaling events	106.0	9274.0	87.0	-0.719	0.168	1000.0	-1000.0	-0.152	-1000.0
FOXM1 transcription factor network	100.0	5141.0	51.0	-0.827	0.04	1000.0	-1000.0	-0.196	-1000.0
PDGFR-alpha signaling pathway	90.0	3963.0	44.0	-0.279	0.034	1000.0	-1000.0	-0.084	-1000.0
JNK signaling in the CD4+ TCR pathway	79.0	1347.0	17.0	-0.429	0.016	1000.0	-1000.0	-0.091	-1000.0
amb2 Integrin signaling	75.0	6164.0	82.0	-0.573	0.016	1000.0	-1000.0	-0.135	-1000.0
IL4-mediated signaling events	72.0	6604.0	91.0	-0.839	0.544	1000.0	-1000.0	-0.165	-1000.0
Glypican 1 network	67.0	3227.0	48.0	-0.573	0.045	1000.0	-1000.0	-0.078	-1000.0
EGFR-dependent Endothelin signaling events	67.0	1420.0	21.0	-0.681	0.016	1000.0	-1000.0	-0.098	-1000.0
Aurora C signaling	65.0	460.0	7.0	-0.404	0.014	1000.0	-1000.0	-0.072	-1000.0
IL23-mediated signaling events	63.0	3796.0	60.0	-0.407	0.021	1000.0	-1000.0	-0.166	-1000.0
Caspase cascade in apoptosis	62.0	4654.0	74.0	-0.327	0.162	1000.0	-1000.0	-0.084	-1000.0
Glypican 2 network	62.0	251.0	4.0	-0.124	-1000.0	1000.0	-1000.0	-0.048	-1000.0
TCGA08_retinoblastoma	61.0	494.0	8.0	-0.846	0.217	1000.0	-1000.0	-0.043	-1000.0
Syndecan-1-mediated signaling events	59.0	2028.0	34.0	-0.413	0.016	1000.0	-1000.0	-0.097	-1000.0
HIF-2-alpha transcription factor network	55.0	2386.0	43.0	-0.765	0.331	1000.0	-1000.0	-0.12	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	54.0	1807.0	33.0	-0.834	0.016	1000.0	-1000.0	-0.098	-1000.0
BMP receptor signaling	53.0	4339.0	81.0	-0.704	0.016	1000.0	-1000.0	-0.145	-1000.0
Signaling events mediated by the Hedgehog family	45.0	2372.0	52.0	-0.449	0.121	1000.0	-1000.0	-0.122	-1000.0
Fc-epsilon receptor I signaling in mast cells	44.0	4345.0	97.0	-0.351	0.042	1000.0	-1000.0	-0.135	-1000.0
IL27-mediated signaling events	40.0	2052.0	51.0	-0.606	0.074	1000.0	-1000.0	-0.121	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	39.0	2697.0	68.0	-0.548	0.067	1000.0	-1000.0	-0.154	-1000.0
Effects of Botulinum toxin	38.0	999.0	26.0	-0.374	0.016	1000.0	-1000.0	-0.095	-1000.0
Ephrin A  reverse signaling	36.0	257.0	7.0	-0.058	0.0	1000.0	-1000.0	-0.048	-1000.0
Calcium signaling in the CD4+ TCR pathway	36.0	1125.0	31.0	-0.478	0.016	1000.0	-1000.0	-0.158	-1000.0
Arf6 signaling events	35.0	2201.0	62.0	-0.681	0.016	1000.0	-1000.0	-0.094	-1000.0
p75(NTR)-mediated signaling	35.0	4498.0	125.0	-0.434	0.016	1000.0	-1000.0	-0.154	-1000.0
IL2 signaling events mediated by STAT5	33.0	747.0	22.0	-0.466	0.038	1000.0	-1000.0	-0.064	-1000.0
VEGFR1 specific signals	33.0	1866.0	56.0	-0.476	0.049	1000.0	-1000.0	-0.121	-1000.0
S1P1 pathway	31.0	1142.0	36.0	-0.379	0.018	1000.0	-1000.0	-0.108	-1000.0
LPA4-mediated signaling events	30.0	360.0	12.0	-0.166	0.028	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	30.0	1797.0	58.0	-0.463	0.033	1000.0	-1000.0	-0.112	-1000.0
BCR signaling pathway	30.0	3014.0	99.0	-0.346	0.034	1000.0	-1000.0	-0.131	-1000.0
PLK1 signaling events	29.0	2513.0	85.0	-0.403	0.016	1000.0	-1000.0	-0.089	-1000.0
Integrins in angiogenesis	29.0	2447.0	84.0	-0.379	0.04	1000.0	-1000.0	-0.143	-1000.0
Coregulation of Androgen receptor activity	27.0	2103.0	76.0	-0.936	0.033	1000.0	-1000.0	-0.076	-1000.0
Glucocorticoid receptor regulatory network	27.0	3123.0	114.0	-0.406	0.151	1000.0	-1000.0	-0.092	-1000.0
Regulation of Telomerase	27.0	2788.0	102.0	-0.681	0.045	1000.0	-1000.0	-0.139	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	25.0	1398.0	54.0	-0.656	0.031	1000.0	-1000.0	-0.138	-1000.0
Reelin signaling pathway	25.0	1401.0	56.0	-0.242	0.016	1000.0	-1000.0	-0.131	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	25.0	2004.0	78.0	-0.321	0.046	1000.0	-1000.0	-0.097	-1000.0
IL6-mediated signaling events	24.0	1855.0	75.0	-0.278	0.078	1000.0	-1000.0	-0.133	-1000.0
Aurora A signaling	22.0	1354.0	60.0	-0.241	0.054	1000.0	-1000.0	-0.091	-1000.0
Visual signal transduction: Rods	21.0	1111.0	52.0	-0.282	0.016	1000.0	-1000.0	-0.128	-1000.0
Signaling events mediated by PTP1B	20.0	1591.0	76.0	-0.684	0.048	1000.0	-1000.0	-0.118	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	20.0	932.0	45.0	-0.593	0.061	1000.0	-1000.0	-0.128	-1000.0
Angiopoietin receptor Tie2-mediated signaling	20.0	1824.0	88.0	-0.324	0.079	1000.0	-1000.0	-0.162	-1000.0
EPO signaling pathway	19.0	1090.0	55.0	-0.294	0.018	1000.0	-1000.0	-0.144	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	19.0	2315.0	120.0	-0.172	0.149	1000.0	-1000.0	-0.113	-1000.0
Syndecan-2-mediated signaling events	18.0	1298.0	69.0	-0.573	0.056	1000.0	-1000.0	-0.105	-1000.0
Regulation of nuclear SMAD2/3 signaling	15.0	2145.0	136.0	-0.461	0.091	1000.0	-1000.0	-0.119	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	15.0	562.0	37.0	-0.301	0.022	1000.0	-1000.0	-0.137	-1000.0
Endothelins	15.0	1533.0	96.0	-0.352	0.089	1000.0	-1000.0	-0.112	-1000.0
Wnt signaling	15.0	111.0	7.0	-0.073	0.016	1000.0	-1000.0	-0.077	-1000.0
S1P3 pathway	15.0	649.0	42.0	-0.375	0.062	1000.0	-1000.0	-0.084	-1000.0
Presenilin action in Notch and Wnt signaling	14.0	908.0	61.0	-0.19	0.092	1000.0	-1000.0	-0.099	-1000.0
FoxO family signaling	14.0	913.0	64.0	-0.57	0.122	1000.0	-1000.0	-0.106	-1000.0
LPA receptor mediated events	14.0	1444.0	102.0	-0.394	0.062	1000.0	-1000.0	-0.129	-1000.0
Sphingosine 1-phosphate (S1P) pathway	13.0	365.0	28.0	-0.135	0.024	1000.0	-1000.0	-0.088	-1000.0
Thromboxane A2 receptor signaling	13.0	1400.0	105.0	-0.681	0.069	1000.0	-1000.0	-0.105	-1000.0
Ceramide signaling pathway	13.0	1032.0	76.0	-0.681	0.234	1000.0	-1000.0	-0.098	-1000.0
Class I PI3K signaling events	13.0	964.0	73.0	-0.483	0.036	1000.0	-1000.0	-0.107	-1000.0
PLK2 and PLK4 events	12.0	38.0	3.0	-0.014	0.01	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	12.0	818.0	68.0	-0.383	0.017	1000.0	-1000.0	-0.139	-1000.0
FAS signaling pathway (CD95)	12.0	604.0	47.0	-0.447	0.031	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	12.0	630.0	51.0	-0.189	0.096	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling events	12.0	62.0	5.0	-0.023	0.016	1000.0	-1000.0	-0.066	-1000.0
ErbB4 signaling events	11.0	777.0	69.0	-0.184	0.106	1000.0	-1000.0	-0.118	-1000.0
Regulation of Androgen receptor activity	11.0	801.0	70.0	-0.974	0.04	1000.0	-1000.0	-0.093	-1000.0
Noncanonical Wnt signaling pathway	10.0	270.0	26.0	-0.122	0.016	1000.0	-1000.0	-0.123	-1000.0
S1P5 pathway	10.0	174.0	17.0	-0.135	0.045	1000.0	-1000.0	-0.081	-1000.0
Nongenotropic Androgen signaling	10.0	551.0	52.0	-0.171	0.074	1000.0	-1000.0	-0.094	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	10.0	1340.0	125.0	-0.401	0.044	1000.0	-1000.0	-0.148	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	762.0	74.0	-0.681	0.1	1000.0	-1000.0	-0.14	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	48.0	5.0	-0.022	0.016	1000.0	-1000.0	-0.061	-1000.0
S1P4 pathway	9.0	249.0	25.0	-0.135	0.035	1000.0	-1000.0	-0.085	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	692.0	82.0	-0.059	0.032	1000.0	-1000.0	-0.119	-1000.0
TCGA08_rtk_signaling	8.0	213.0	26.0	-0.281	0.041	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	7.0	296.0	38.0	-0.036	0.016	1000.0	-1000.0	-0.1	-1000.0
Canonical NF-kappaB pathway	6.0	256.0	39.0	-0.201	0.074	1000.0	-1000.0	-0.121	-1000.0
Signaling events mediated by PRL	6.0	219.0	34.0	-0.056	0.049	1000.0	-1000.0	-0.089	-1000.0
ErbB2/ErbB3 signaling events	5.0	368.0	65.0	-0.132	0.061	1000.0	-1000.0	-0.1	-1000.0
Insulin-mediated glucose transport	5.0	166.0	32.0	-0.079	0.067	1000.0	-1000.0	-0.099	-1000.0
Signaling events mediated by HDAC Class III	5.0	208.0	40.0	-0.065	0.032	1000.0	-1000.0	-0.069	-1000.0
IL1-mediated signaling events	5.0	355.0	62.0	-0.096	0.062	1000.0	-1000.0	-0.137	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	76.0	15.0	0.0	0.037	1000.0	-1000.0	-0.056	-1000.0
Syndecan-3-mediated signaling events	5.0	187.0	35.0	-0.04	0.016	1000.0	-1000.0	-0.099	-1000.0
Arf6 trafficking events	5.0	366.0	71.0	-0.129	0.05	1000.0	-1000.0	-0.113	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.02	-1000.0
Arf6 downstream pathway	4.0	198.0	43.0	-0.034	0.034	1000.0	-1000.0	-0.065	-1000.0
Ephrin B reverse signaling	4.0	215.0	48.0	-0.022	0.034	1000.0	-1000.0	-0.11	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	357.0	76.0	-0.026	0.068	1000.0	-1000.0	-0.135	-1000.0
p38 MAPK signaling pathway	4.0	182.0	44.0	-0.107	0.051	1000.0	-1000.0	-0.091	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	71.0	17.0	-0.037	0.055	1000.0	-1000.0	-0.068	-1000.0
BARD1 signaling events	3.0	188.0	57.0	-0.177	0.044	1000.0	-1000.0	-0.107	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	314.0	85.0	-0.037	0.081	1000.0	-1000.0	-0.112	-1000.0
EPHB forward signaling	3.0	298.0	85.0	-0.073	0.075	1000.0	-1000.0	-0.146	-1000.0
Osteopontin-mediated events	2.0	87.0	38.0	-0.029	0.105	1000.0	-1000.0	-0.147	-1000.0
Cellular roles of Anthrax toxin	2.0	108.0	39.0	-0.023	0.028	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	2.0	129.0	49.0	-0.12	0.054	1000.0	-1000.0	-0.081	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	125.0	52.0	-0.029	0.092	1000.0	-1000.0	-0.092	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	98.0	36.0	-0.031	0.031	1000.0	-1000.0	-0.102	-1000.0
Regulation of p38-alpha and p38-beta	2.0	136.0	54.0	-0.04	0.074	1000.0	-1000.0	-0.081	-1000.0
Insulin Pathway	2.0	168.0	74.0	-0.034	0.057	1000.0	-1000.0	-0.135	-1000.0
Plasma membrane estrogen receptor signaling	2.0	255.0	86.0	-0.158	0.076	1000.0	-1000.0	-0.128	-1000.0
PDGFR-beta signaling pathway	2.0	236.0	97.0	-0.057	0.09	1000.0	-1000.0	-0.13	-1000.0
E-cadherin signaling in keratinocytes	2.0	124.0	43.0	-0.299	0.056	1000.0	-1000.0	-0.11	-1000.0
Signaling events mediated by HDAC Class II	1.0	101.0	75.0	-0.026	0.051	1000.0	-1000.0	-0.099	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	110.0	65.0	-0.062	0.093	1000.0	-1000.0	-0.097	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	81.0	68.0	-0.079	0.061	1000.0	-1000.0	-0.103	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	154.0	83.0	-0.079	0.081	1000.0	-1000.0	-0.118	-1000.0
Signaling events mediated by HDAC Class I	1.0	146.0	104.0	-0.029	0.064	1000.0	-1000.0	-0.107	-1000.0
Retinoic acid receptors-mediated signaling	1.0	93.0	58.0	-0.022	0.065	1000.0	-1000.0	-0.104	-1000.0
Atypical NF-kappaB pathway	1.0	37.0	31.0	-0.024	0.036	1000.0	-1000.0	-0.102	-1000.0
IGF1 pathway	1.0	57.0	57.0	-0.068	0.073	1000.0	-1000.0	-0.152	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.063	1000.0	-1000.0	-0.118	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.019	0.066	1000.0	-1000.0	-0.087	-1000.0
mTOR signaling pathway	0.0	52.0	53.0	-0.005	0.046	1000.0	-1000.0	-0.088	-1000.0
Nectin adhesion pathway	0.0	27.0	63.0	-0.015	0.082	1000.0	-1000.0	-0.103	-1000.0
TRAIL signaling pathway	0.0	21.0	48.0	-0.002	0.072	1000.0	-1000.0	-0.093	-1000.0
Signaling mediated by p38-alpha and p38-beta	0.0	42.0	44.0	-0.043	0.052	1000.0	-1000.0	-0.077	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.039	1000.0	-1000.0	-0.08	-1000.0
Rapid glucocorticoid signaling	0.0	10.0	20.0	-0.005	0.016	1000.0	-1000.0	-0.053	-1000.0
Arf1 pathway	0.0	25.0	54.0	-0.011	0.035	1000.0	-1000.0	-0.064	-1000.0
Alternative NF-kappaB pathway	0.0	8.0	13.0	-0.006	0.016	1000.0	-1000.0	-0.099	-1000.0
Total	3556	199670	7203	-40.6709050672	-991.758356315	131000	-131000	-13.6064090187	-131000