Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	39.0	314.0	8.0	-0.081	0.054	1000.0	-1000.0	-0.004	-1000.0
E-cadherin signaling events	35.0	177.0	5.0	-0.098	0.017	1000.0	-1000.0	-0.001	-1000.0
Osteopontin-mediated events	32.0	1243.0	38.0	-0.173	0.021	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	31.0	3986.0	125.0	-0.23	0.026	1000.0	-1000.0	-0.039	-1000.0
LPA receptor mediated events	31.0	3221.0	102.0	-0.172	0.017	1000.0	-1000.0	-0.036	-1000.0
Ephrin B reverse signaling	28.0	1354.0	48.0	-0.108	0.074	1000.0	-1000.0	-0.017	-1000.0
Integrins in angiogenesis	28.0	2392.0	84.0	-0.188	0.026	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	28.0	2481.0	88.0	-0.278	0.046	1000.0	-1000.0	-0.047	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	27.0	924.0	34.0	-0.108	0.017	1000.0	-1000.0	-0.009	-1000.0
Syndecan-1-mediated signaling events	27.0	937.0	34.0	-0.127	0.017	1000.0	-1000.0	-0.013	-1000.0
Thromboxane A2 receptor signaling	27.0	2841.0	105.0	-0.185	0.08	1000.0	-1000.0	-0.034	-1000.0
Syndecan-2-mediated signaling events	27.0	1922.0	69.0	-0.108	0.026	1000.0	-1000.0	-0.005	-1000.0
Endothelins	27.0	2648.0	96.0	-0.226	0.064	1000.0	-1000.0	-0.024	-1000.0
EPHB forward signaling	27.0	2305.0	85.0	-0.119	0.083	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	27.0	192.0	7.0	-0.076	0.015	1000.0	-1000.0	-0.004	-1000.0
Nectin adhesion pathway	26.0	1661.0	63.0	-0.176	0.022	1000.0	-1000.0	-0.038	-1000.0
IL4-mediated signaling events	25.0	2342.0	91.0	-0.546	0.473	1000.0	-1000.0	-0.105	-1000.0
amb2 Integrin signaling	25.0	2053.0	82.0	-0.128	0.023	1000.0	-1000.0	-0.017	-1000.0
Noncanonical Wnt signaling pathway	24.0	625.0	26.0	-0.079	0.017	1000.0	-1000.0	-0.008	-1000.0
Fc-epsilon receptor I signaling in mast cells	24.0	2368.0	97.0	-0.242	0.038	1000.0	-1000.0	-0.037	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	23.0	1723.0	74.0	-0.098	0.03	1000.0	-1000.0	-0.037	-1000.0
p75(NTR)-mediated signaling	22.0	2794.0	125.0	-0.139	0.051	1000.0	-1000.0	-0.04	-1000.0
BMP receptor signaling	22.0	1793.0	81.0	-0.105	0.035	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	22.0	1009.0	44.0	-0.076	0.024	1000.0	-1000.0	-0.011	-1000.0
E-cadherin signaling in keratinocytes	22.0	955.0	43.0	-0.097	0.021	1000.0	-1000.0	-0.008	-1000.0
HIF-1-alpha transcription factor network	21.0	1643.0	76.0	-0.214	0.025	1000.0	-1000.0	-0.037	-1000.0
Nongenotropic Androgen signaling	21.0	1139.0	52.0	-0.142	0.034	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling in the nascent adherens junction	21.0	1633.0	76.0	-0.103	0.026	1000.0	-1000.0	-0.035	-1000.0
Syndecan-4-mediated signaling events	21.0	1443.0	67.0	-0.16	0.026	1000.0	-1000.0	-0.014	-1000.0
S1P1 pathway	20.0	735.0	36.0	-0.107	0.017	1000.0	-1000.0	-0.027	-1000.0
Syndecan-3-mediated signaling events	20.0	716.0	35.0	-0.1	0.051	1000.0	-1000.0	-0.017	-1000.0
LPA4-mediated signaling events	18.0	227.0	12.0	-0.05	0.006	1000.0	-1000.0	-0.001	-1000.0
IL12-mediated signaling events	18.0	1578.0	87.0	-0.257	0.047	1000.0	-1000.0	-0.083	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	18.0	1270.0	68.0	-0.325	0.144	1000.0	-1000.0	-0.043	-1000.0
IL23-mediated signaling events	18.0	1118.0	60.0	-0.42	0.017	1000.0	-1000.0	-0.041	-1000.0
Cellular roles of Anthrax toxin	17.0	689.0	39.0	-0.117	0.017	1000.0	-1000.0	-0.01	-1000.0
S1P3 pathway	17.0	738.0	42.0	-0.103	0.026	1000.0	-1000.0	-0.01	-1000.0
PDGFR-beta signaling pathway	17.0	1671.0	97.0	-0.115	0.021	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	16.0	1044.0	62.0	-0.108	0.023	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by PTP1B	16.0	1245.0	76.0	-0.118	0.03	1000.0	-1000.0	-0.023	-1000.0
HIF-2-alpha transcription factor network	16.0	695.0	43.0	-0.219	0.11	1000.0	-1000.0	-0.038	-1000.0
TCR signaling in naïve CD8+ T cells	16.0	1496.0	93.0	-0.073	0.026	1000.0	-1000.0	-0.03	-1000.0
Effects of Botulinum toxin	16.0	438.0	26.0	-0.118	0.017	1000.0	-1000.0	-0.004	-1000.0
EGFR-dependent Endothelin signaling events	16.0	351.0	21.0	-0.087	0.026	1000.0	-1000.0	-0.027	-1000.0
IGF1 pathway	16.0	919.0	57.0	-0.127	0.035	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	16.0	1378.0	86.0	-0.132	0.058	1000.0	-1000.0	-0.035	-1000.0
Coregulation of Androgen receptor activity	15.0	1206.0	76.0	-0.153	0.035	1000.0	-1000.0	-0.015	-1000.0
Signaling events regulated by Ret tyrosine kinase	15.0	1271.0	82.0	-0.116	0.017	1000.0	-1000.0	-0.038	-1000.0
Signaling mediated by p38-alpha and p38-beta	15.0	665.0	44.0	-0.096	0.017	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	15.0	1186.0	78.0	-0.103	0.032	1000.0	-1000.0	-0.019	-1000.0
Glypican 1 network	14.0	695.0	48.0	-0.12	0.028	1000.0	-1000.0	-0.011	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	14.0	1709.0	120.0	-0.16	0.05	1000.0	-1000.0	-0.033	-1000.0
Caspase cascade in apoptosis	13.0	1020.0	74.0	-0.198	0.039	1000.0	-1000.0	-0.017	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1161.0	85.0	-0.127	0.017	1000.0	-1000.0	-0.033	-1000.0
Reelin signaling pathway	13.0	765.0	56.0	-0.112	0.047	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	13.0	860.0	62.0	-0.103	0.047	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	13.0	765.0	56.0	-0.066	0.017	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by PRL	13.0	450.0	34.0	-0.049	0.026	1000.0	-1000.0	-0.005	-1000.0
S1P5 pathway	12.0	219.0	17.0	-0.069	0.022	1000.0	-1000.0	-0.002	-1000.0
TCGA08_p53	12.0	90.0	7.0	-0.06	0.051	1000.0	-1000.0	-0.003	-1000.0
Canonical Wnt signaling pathway	12.0	647.0	51.0	-0.128	0.032	1000.0	-1000.0	-0.026	-1000.0
Glypican 2 network	12.0	51.0	4.0	-0.004	-0.001	1000.0	-1000.0	0.0	-1000.0
Signaling events mediated by the Hedgehog family	11.0	586.0	52.0	-0.063	0.026	1000.0	-1000.0	-0.023	-1000.0
Glucocorticoid receptor regulatory network	11.0	1299.0	114.0	-0.307	0.171	1000.0	-1000.0	-0.035	-1000.0
Ceramide signaling pathway	11.0	848.0	76.0	-0.098	0.047	1000.0	-1000.0	-0.014	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	11.0	431.0	37.0	-0.16	0.042	1000.0	-1000.0	-0.01	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1467.0	136.0	-0.184	0.111	1000.0	-1000.0	-0.023	-1000.0
PLK2 and PLK4 events	10.0	30.0	3.0	-0.009	0.013	1000.0	-1000.0	-0.001	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	638.0	61.0	-0.129	0.051	1000.0	-1000.0	-0.026	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	10.0	553.0	52.0	-0.126	0.021	1000.0	-1000.0	-0.011	-1000.0
Retinoic acid receptors-mediated signaling	10.0	630.0	58.0	-0.118	0.035	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	331.0	31.0	-0.084	0.017	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	10.0	555.0	51.0	-0.215	0.032	1000.0	-1000.0	-0.106	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	277.0	28.0	-0.092	0.04	1000.0	-1000.0	-0.005	-1000.0
Hedgehog signaling events mediated by Gli proteins	9.0	589.0	65.0	-0.075	0.041	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class III	9.0	365.0	40.0	-0.131	0.038	1000.0	-1000.0	-0.006	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	348.0	36.0	-0.16	0.045	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	122.0	15.0	-0.012	0.019	1000.0	-1000.0	-0.006	-1000.0
Visual signal transduction: Cones	7.0	281.0	38.0	-0.04	0.019	1000.0	-1000.0	-0.007	-1000.0
Regulation of p38-alpha and p38-beta	7.0	383.0	54.0	-0.077	0.044	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events	7.0	554.0	73.0	-0.096	0.025	1000.0	-1000.0	-0.015	-1000.0
S1P4 pathway	7.0	187.0	25.0	-0.069	0.032	1000.0	-1000.0	-0.008	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	119.0	17.0	-0.035	0.033	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by HDAC Class II	6.0	520.0	75.0	-0.075	0.038	1000.0	-1000.0	-0.02	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	368.0	54.0	-0.112	0.041	1000.0	-1000.0	-0.037	-1000.0
Arf6 downstream pathway	6.0	300.0	43.0	-0.039	0.028	1000.0	-1000.0	-0.012	-1000.0
FAS signaling pathway (CD95)	6.0	318.0	47.0	-0.073	0.035	1000.0	-1000.0	-0.012	-1000.0
IL6-mediated signaling events	6.0	489.0	75.0	-0.191	0.067	1000.0	-1000.0	-0.019	-1000.0
BCR signaling pathway	6.0	598.0	99.0	-0.075	0.049	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Rods	6.0	334.0	52.0	-0.076	0.021	1000.0	-1000.0	-0.033	-1000.0
ErbB4 signaling events	5.0	375.0	69.0	-0.144	0.04	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	5.0	168.0	32.0	-0.049	0.035	1000.0	-1000.0	-0.01	-1000.0
TRAIL signaling pathway	5.0	276.0	48.0	-0.036	0.041	1000.0	-1000.0	-0.014	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	248.0	45.0	-0.05	0.053	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by STAT5	5.0	124.0	22.0	-0.052	0.046	1000.0	-1000.0	-0.021	-1000.0
Regulation of Telomerase	5.0	594.0	102.0	-0.132	0.05	1000.0	-1000.0	-0.054	-1000.0
Insulin Pathway	5.0	375.0	74.0	-0.075	0.041	1000.0	-1000.0	-0.036	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.006	0.006	1000.0	-1000.0	-0.001	-1000.0
Canonical NF-kappaB pathway	4.0	180.0	39.0	-0.058	0.047	1000.0	-1000.0	-0.028	-1000.0
Ephrin A  reverse signaling	4.0	33.0	7.0	-0.002	0.008	1000.0	-1000.0	-0.002	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	74.0	17.0	-0.026	0.031	1000.0	-1000.0	-0.015	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	378.0	83.0	-0.047	0.041	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by HDAC Class I	4.0	439.0	104.0	-0.075	0.056	1000.0	-1000.0	-0.019	-1000.0
IL27-mediated signaling events	4.0	211.0	51.0	-0.062	0.035	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	4.0	105.0	26.0	-0.051	0.036	1000.0	-1000.0	-0.005	-1000.0
Regulation of Androgen receptor activity	4.0	285.0	70.0	-0.098	0.03	1000.0	-1000.0	-0.016	-1000.0
Aurora B signaling	4.0	293.0	67.0	-0.083	0.039	1000.0	-1000.0	-0.024	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	70.0	23.0	-0.036	0.04	1000.0	-1000.0	-0.011	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	149.0	46.0	-0.128	0.024	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	3.0	186.0	55.0	-0.006	0.069	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	3.0	246.0	68.0	-0.032	0.058	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	3.0	120.0	31.0	-0.026	0.033	1000.0	-1000.0	-0.005	-1000.0
Arf6 trafficking events	3.0	213.0	71.0	-0.066	0.044	1000.0	-1000.0	-0.021	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	129.0	33.0	-0.086	0.05	1000.0	-1000.0	-0.011	-1000.0
Rapid glucocorticoid signaling	3.0	67.0	20.0	-0.015	0.017	1000.0	-1000.0	-0.003	-1000.0
Arf1 pathway	3.0	175.0	54.0	-0.018	0.031	1000.0	-1000.0	-0.009	-1000.0
ErbB2/ErbB3 signaling events	2.0	150.0	65.0	-0.069	0.042	1000.0	-1000.0	-0.031	-1000.0
Circadian rhythm pathway	2.0	44.0	22.0	-0.013	0.043	1000.0	-1000.0	-0.018	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	12.0	5.0	0.005	0.026	1000.0	-1000.0	-0.003	-1000.0
PLK1 signaling events	2.0	193.0	85.0	-0.019	0.039	1000.0	-1000.0	-0.018	-1000.0
ceramide signaling pathway	2.0	116.0	49.0	-0.05	0.035	1000.0	-1000.0	-0.014	-1000.0
FoxO family signaling	2.0	173.0	64.0	-0.1	0.101	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by PI3K	2.0	170.0	58.0	-0.056	0.07	1000.0	-1000.0	-0.025	-1000.0
p38 MAPK signaling pathway	2.0	91.0	44.0	-0.006	0.04	1000.0	-1000.0	-0.026	-1000.0
BARD1 signaling events	1.0	57.0	57.0	-0.037	0.063	1000.0	-1000.0	-0.015	-1000.0
Aurora C signaling	1.0	12.0	7.0	-0.0	0.025	1000.0	-1000.0	-0.005	-1000.0
mTOR signaling pathway	1.0	76.0	53.0	-0.01	0.035	1000.0	-1000.0	-0.031	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	124.0	68.0	-0.037	0.046	1000.0	-1000.0	-0.015	-1000.0
Aurora A signaling	0.0	58.0	60.0	-0.003	0.048	1000.0	-1000.0	-0.007	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.044	1000.0	-1000.0	-0.025	-1000.0
Alternative NF-kappaB pathway	0.0	10.0	13.0	-0.0	0.048	1000.0	-1000.0	-0.005	-1000.0
Total	1623	99520	7203	-13.6000675015	5.45590542269	131000	-131000	-2.95201117047	-131000