Correlation between copy number variation genes (focal) and selected clinical features
Lung Adenocarcinoma (Primary solid tumor)
22 February 2013  |  analyses__2013_02_22
Maintainer Information
Citation Information
doi:10.7908/C1RN362Z
Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): Correlation between copy number variation genes (focal) and selected clinical features. Broad Institute of MIT and Harvard. doi:10.7908/C1RN362Z
Overview
Introduction

This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.

Summary

Testing the association between subtypes identified by 77 different clustering approaches and 14 clinical features across 337 patients, 7 significant findings detected with Q value < 0.25.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 1(1p34.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 2(1p22.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 3(1q21.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 4(3q26.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 5(4q12) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 6(5p15.33) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 7(5p13.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 8(5q35.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 9(6p25.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 10(6p21.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 11(7p21.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 12(7p11.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 13(7q31.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 14(8p11.21) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 15(8q11.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 16(8q24.21) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 17(10p15.1) mutation analysis'. These subtypes correlate to 'STOPPEDSMOKINGYEAR' and 'TOBACCOSMOKINGHISTORYINDICATOR'.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 18(11q13.3) mutation analysis'. These subtypes correlate to 'AGE'.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 19(12p12.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 20(12q14.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 21(12q15) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 22(13q33.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 23(14q13.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 24(17q12) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 25(17q23.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 26(18p11.32) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 27(18q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 28(19q12) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 29(20q11.21) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 30(20q13.33) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 31(22q11.22) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Amp Peak 32(Xq28) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 1(1p36.13) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 2(1p13.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 3(2q22.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 4(2q37.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 5(3p26.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 6(3p21.31) mutation analysis'. These subtypes correlate to 'YEAROFTOBACCOSMOKINGONSET'.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 7(3q11.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 8(3q29) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 9(4p15.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 10(4q22.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 11(4q35.1) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 12(5q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 13(5q34) mutation analysis'. These subtypes correlate to 'STOPPEDSMOKINGYEAR' and 'TOBACCOSMOKINGHISTORYINDICATOR'.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 14(6q12) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 15(6q22.31) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 16(6q26) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 17(8p23.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 18(8p21.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 19(9p23) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 20(9p21.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 21(9q21.11) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 22(10p15.3) mutation analysis'. These subtypes correlate to 'GENDER'.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 23(10q26.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 24(11p15.5) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 25(11q25) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 26(12p13.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 27(12q12) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 28(12q24.33) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 29(13q12.11) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 30(13q12.13) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 31(13q34) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 32(14q32.33) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 33(15q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 34(15q15.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 35(16q23.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 36(17p13.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 37(18q21.32) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 38(18q23) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 39(19p13.3) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 40(19p13.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 41(19q11) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 42(19q13.33) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 43(21q11.2) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 44(22q13.32) mutation analysis'. These subtypes do not correlate to any clinical features.

  • 2 subtypes identified in current cancer cohort by 'Del Peak 45(Xp22.2) mutation analysis'. These subtypes do not correlate to any clinical features.

Results
Overview of the results

Table 1.  Get Full Table Overview of the association between subtypes identified by 77 different clustering approaches and 14 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 7 significant findings detected.

Clinical
Features 		Time
to
Death 		AGE GENDER KARNOFSKY
PERFORMANCE
SCORE 		HISTOLOGICAL
TYPE 		PATHOLOGY
T 		PATHOLOGY
N 		PATHOLOGICSPREAD(M) TUMOR
STAGE 		RADIATIONS
RADIATION
REGIMENINDICATION 		NUMBERPACKYEARSSMOKED STOPPEDSMOKINGYEAR TOBACCOSMOKINGHISTORYINDICATOR YEAROFTOBACCOSMOKINGONSET
Statistical Tests logrank test t-test Fisher's exact test t-test Chi-square test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test Fisher's exact test t-test t-test Fisher's exact test t-test
Amp Peak 1(1p34 3) 0.912
(1.00) 		0.0124
(1.00) 		0.81
(1.00) 		0.421
(1.00) 		0.462
(1.00) 		0.633
(1.00) 		0.237
(1.00) 		0.956
(1.00) 		0.577
(1.00) 		0.455
(1.00) 		0.683
(1.00) 		0.57
(1.00) 		0.104
(1.00) 		0.784
(1.00)
Amp Peak 2(1p22 3) 0.754
(1.00) 		0.000979
(1.00) 		1
(1.00) 		0.609
(1.00) 		0.134
(1.00) 		0.806
(1.00) 		0.066
(1.00) 		0.623
(1.00) 		0.273
(1.00) 		0.446
(1.00) 		0.277
(1.00) 		0.376
(1.00) 		0.636
(1.00) 		0.473
(1.00)
Amp Peak 3(1q21 3) 0.339
(1.00) 		0.304
(1.00) 		0.0666
(1.00) 		0.311
(1.00) 		0.0173
(1.00) 		0.668
(1.00) 		0.936
(1.00) 		0.213
(1.00) 		0.966
(1.00) 		0.301
(1.00) 		0.901
(1.00) 		0.765
(1.00) 		0.185
(1.00) 		0.141
(1.00)
Amp Peak 4(3q26 2) 0.906
(1.00) 		0.424
(1.00) 		0.909
(1.00) 		0.726
(1.00) 		0.743
(1.00) 		0.727
(1.00) 		0.159
(1.00) 		0.602
(1.00) 		0.529
(1.00) 		0.47
(1.00) 		0.0833
(1.00) 		0.0263
(1.00) 		0.0347
(1.00) 		0.127
(1.00)
Amp Peak 5(4q12) 0.228
(1.00) 		0.00834
(1.00) 		0.587
(1.00) 		0.902
(1.00) 		0.328
(1.00) 		0.196
(1.00) 		0.373
(1.00) 		0.242
(1.00) 		0.522
(1.00) 		0.775
(1.00) 		0.612
(1.00) 		0.64
(1.00) 		0.928
(1.00) 		0.301
(1.00)
Amp Peak 6(5p15 33) 0.194
(1.00) 		0.00485
(1.00) 		0.0116
(1.00) 		0.0263
(1.00) 		0.0553
(1.00) 		0.136
(1.00) 		0.479
(1.00) 		0.565
(1.00) 		0.313
(1.00) 		0.47
(1.00) 		0.105
(1.00) 		0.0263
(1.00) 		0.107
(1.00) 		0.37
(1.00)
Amp Peak 7(5p13 1) 0.11
(1.00) 		0.012
(1.00) 		0.0454
(1.00) 		0.867
(1.00) 		0.14
(1.00) 		0.208
(1.00) 		0.34
(1.00) 		0.923
(1.00) 		0.368
(1.00) 		1
(1.00) 		0.0157
(1.00) 		0.0221
(1.00) 		0.23
(1.00) 		0.782
(1.00)
Amp Peak 8(5q35 1) 0.105
(1.00) 		0.285
(1.00) 		0.0382
(1.00) 		0.971
(1.00) 		0.512
(1.00) 		0.398
(1.00) 		0.558
(1.00) 		0.939
(1.00) 		0.585
(1.00) 		0.429
(1.00) 		0.651
(1.00) 		0.354
(1.00) 		0.0551
(1.00) 		0.119
(1.00)
Amp Peak 9(6p25 3) 0.528
(1.00) 		0.125
(1.00) 		0.655
(1.00) 		0.863
(1.00) 		0.325
(1.00) 		0.528
(1.00) 		0.0308
(1.00) 		0.222
(1.00) 		0.0405
(1.00) 		0.357
(1.00) 		0.913
(1.00) 		0.56
(1.00) 		0.0503
(1.00) 		0.428
(1.00)
Amp Peak 10(6p21 1) 0.645
(1.00) 		0.299
(1.00) 		0.365
(1.00) 		0.924
(1.00) 		0.644
(1.00) 		0.531
(1.00) 		0.177
(1.00) 		0.0926
(1.00) 		0.341
(1.00) 		0.635
(1.00) 		0.522
(1.00) 		0.805
(1.00) 		0.0182
(1.00) 		0.58
(1.00)
Amp Peak 11(7p21 1) 0.762
(1.00) 		0.343
(1.00) 		0.271
(1.00) 		0.908
(1.00) 		0.272
(1.00) 		0.146
(1.00) 		0.0433
(1.00) 		0.437
(1.00) 		0.539
(1.00) 		1
(1.00) 		0.763
(1.00) 		0.667
(1.00) 		0.0698
(1.00) 		0.887
(1.00)
Amp Peak 12(7p11 2) 0.182
(1.00) 		0.118
(1.00) 		0.381
(1.00) 		0.695
(1.00) 		0.216
(1.00) 		0.106
(1.00) 		0.00589
(1.00) 		0.528
(1.00) 		0.243
(1.00) 		0.822
(1.00) 		0.719
(1.00) 		0.604
(1.00) 		0.1
(1.00) 		0.175
(1.00)
Amp Peak 13(7q31 2) 0.967
(1.00) 		0.0473
(1.00) 		0.658
(1.00) 		0.376
(1.00) 		0.391
(1.00) 		0.37
(1.00) 		0.256
(1.00) 		0.585
(1.00) 		0.36
(1.00) 		0.247
(1.00) 		0.284
(1.00) 		0.176
(1.00) 		0.277
(1.00) 		0.794
(1.00)
Amp Peak 14(8p11 21) 0.832
(1.00) 		0.137
(1.00) 		0.0744
(1.00) 		0.143
(1.00) 		0.11
(1.00) 		0.852
(1.00) 		0.287
(1.00) 		0.435
(1.00) 		0.389
(1.00) 		0.626
(1.00) 		0.59
(1.00) 		0.15
(1.00) 		0.134
(1.00) 		0.602
(1.00)
Amp Peak 15(8q11 1) 0.828
(1.00) 		0.0321
(1.00) 		0.66
(1.00) 		0.913
(1.00) 		0.0912
(1.00) 		0.614
(1.00) 		0.295
(1.00) 		0.834
(1.00) 		0.401
(1.00) 		1
(1.00) 		0.573
(1.00) 		0.342
(1.00) 		0.015
(1.00) 		0.2
(1.00)
Amp Peak 16(8q24 21) 0.231
(1.00) 		0.138
(1.00) 		0.653
(1.00) 		0.885
(1.00) 		0.0217
(1.00) 		0.569
(1.00) 		0.633
(1.00) 		0.88
(1.00) 		0.833
(1.00) 		0.635
(1.00) 		0.74
(1.00) 		0.438
(1.00) 		0.0409
(1.00) 		0.567
(1.00)
Amp Peak 17(10p15 1) 0.128
(1.00) 		0.456
(1.00) 		0.0377
(1.00) 		0.571
(1.00) 		0.407
(1.00) 		0.726
(1.00) 		0.0286
(1.00) 		0.794
(1.00) 		0.523
(1.00) 		0.608
(1.00) 		0.00397
(1.00) 		0.000211
(0.226) 		1.99e-06
(0.00214) 		0.944
(1.00)
Amp Peak 18(11q13 3) 0.815
(1.00) 		3.36e-05
(0.0361) 		0.304
(1.00) 		0.519
(1.00) 		0.469
(1.00) 		0.469
(1.00) 		0.796
(1.00) 		0.576
(1.00) 		0.354
(1.00) 		0.81
(1.00) 		0.853
(1.00) 		0.0772
(1.00) 		0.00391
(1.00) 		0.755
(1.00)
Amp Peak 19(12p12 1) 0.0342
(1.00) 		0.324
(1.00) 		1
(1.00) 		0.821
(1.00) 		0.626
(1.00) 		0.563
(1.00) 		0.59
(1.00) 		0.562
(1.00) 		0.796
(1.00) 		0.638
(1.00) 		0.798
(1.00) 		0.348
(1.00) 		0.113
(1.00) 		0.288
(1.00)
Amp Peak 20(12q14 1) 0.181
(1.00) 		0.084
(1.00) 		0.483
(1.00) 		0.558
(1.00) 		0.815
(1.00) 		0.51
(1.00) 		0.716
(1.00) 		0.475
(1.00) 		0.427
(1.00) 		1
(1.00) 		0.392
(1.00) 		0.0014
(1.00) 		0.0785
(1.00) 		0.00176
(1.00)
Amp Peak 21(12q15) 0.437
(1.00) 		0.233
(1.00) 		0.56
(1.00) 		0.321
(1.00) 		0.818
(1.00) 		0.747
(1.00) 		0.496
(1.00) 		0.757
(1.00) 		0.682
(1.00) 		0.809
(1.00) 		0.233
(1.00) 		0.0434
(1.00) 		0.05
(1.00) 		0.00515
(1.00)
Amp Peak 22(13q33 3) 0.892
(1.00) 		0.783
(1.00) 		0.144
(1.00) 		0.935
(1.00) 		0.324
(1.00) 		0.388
(1.00) 		0.359
(1.00) 		0.605
(1.00) 		1
(1.00) 		0.173
(1.00) 		0.721
(1.00) 		0.718
(1.00) 		0.742
(1.00)
Amp Peak 23(14q13 3) 0.376
(1.00) 		0.663
(1.00) 		0.508
(1.00) 		0.538
(1.00) 		0.331
(1.00) 		0.908
(1.00) 		0.859
(1.00) 		0.141
(1.00) 		0.669
(1.00) 		0.49
(1.00) 		0.949
(1.00) 		0.0987
(1.00) 		0.26
(1.00) 		0.136
(1.00)
Amp Peak 24(17q12) 0.914
(1.00) 		0.807
(1.00) 		1
(1.00) 		0.0981
(1.00) 		0.44
(1.00) 		0.786
(1.00) 		0.622
(1.00) 		0.596
(1.00) 		0.608
(1.00) 		0.103
(1.00) 		0.00949
(1.00) 		0.0493
(1.00) 		0.242
(1.00) 		0.52
(1.00)
Amp Peak 25(17q23 1) 0.566
(1.00) 		0.259
(1.00) 		0.661
(1.00) 		0.591
(1.00) 		0.0966
(1.00) 		0.504
(1.00) 		0.452
(1.00) 		0.763
(1.00) 		0.678
(1.00) 		0.647
(1.00) 		0.0507
(1.00) 		0.0177
(1.00) 		0.131
(1.00) 		0.444
(1.00)
Amp Peak 26(18p11 32) 0.172
(1.00) 		0.332
(1.00) 		0.805
(1.00) 		0.882
(1.00) 		0.513
(1.00) 		0.842
(1.00) 		0.477
(1.00) 		0.933
(1.00) 		0.915
(1.00) 		0.302
(1.00) 		0.167
(1.00) 		0.155
(1.00) 		0.211
(1.00) 		0.228
(1.00)
Amp Peak 27(18q11 2) 0.961
(1.00) 		0.819
(1.00) 		0.351
(1.00) 		0.752
(1.00) 		0.0558
(1.00) 		0.937
(1.00) 		0.662
(1.00) 		0.27
(1.00) 		0.327
(1.00) 		0.267
(1.00) 		0.436
(1.00) 		0.783
(1.00) 		0.0579
(1.00) 		0.594
(1.00)
Amp Peak 28(19q12) 0.695
(1.00) 		0.584
(1.00) 		0.0498
(1.00) 		0.259
(1.00) 		0.461
(1.00) 		0.436
(1.00) 		0.427
(1.00) 		0.86
(1.00) 		0.442
(1.00) 		0.301
(1.00) 		0.205
(1.00) 		0.0141
(1.00) 		0.739
(1.00) 		0.341
(1.00)
Amp Peak 29(20q11 21) 0.502
(1.00) 		0.694
(1.00) 		0.826
(1.00) 		0.192
(1.00) 		0.259
(1.00) 		0.0214
(1.00) 		0.382
(1.00) 		0.134
(1.00) 		0.331
(1.00) 		0.249
(1.00) 		0.00379
(1.00) 		0.607
(1.00) 		0.387
(1.00) 		0.151
(1.00)
Amp Peak 30(20q13 33) 0.445
(1.00) 		0.302
(1.00) 		0.913
(1.00) 		0.274
(1.00) 		0.0685
(1.00) 		0.163
(1.00) 		0.369
(1.00) 		0.0775
(1.00) 		0.124
(1.00) 		0.493
(1.00) 		0.272
(1.00) 		0.102
(1.00) 		0.151
(1.00) 		0.741
(1.00)
Amp Peak 31(22q11 22) 0.304
(1.00) 		0.624
(1.00) 		0.243
(1.00) 		0.372
(1.00) 		0.53
(1.00) 		0.557
(1.00) 		0.081
(1.00) 		0.197
(1.00) 		1
(1.00) 		0.751
(1.00) 		0.548
(1.00) 		0.638
(1.00) 		0.443
(1.00)
Amp Peak 32(Xq28) 0.188
(1.00) 		0.202
(1.00) 		0.164
(1.00) 		0.288
(1.00) 		0.319
(1.00) 		0.628
(1.00) 		0.312
(1.00) 		0.458
(1.00) 		0.546
(1.00) 		1
(1.00) 		0.385
(1.00) 		0.744
(1.00) 		0.0608
(1.00) 		0.812
(1.00)
Del Peak 1(1p36 13) 0.0342
(1.00) 		0.573
(1.00) 		0.0387
(1.00) 		0.447
(1.00) 		0.631
(1.00) 		0.0765
(1.00) 		0.0333
(1.00) 		0.57
(1.00) 		0.0531
(1.00) 		0.423
(1.00) 		0.949
(1.00) 		0.561
(1.00) 		0.389
(1.00) 		0.825
(1.00)
Del Peak 2(1p13 1) 0.659
(1.00) 		0.246
(1.00) 		0.72
(1.00) 		0.746
(1.00) 		0.616
(1.00) 		0.389
(1.00) 		0.358
(1.00) 		0.541
(1.00) 		0.0571
(1.00) 		1
(1.00) 		0.501
(1.00) 		0.374
(1.00) 		0.699
(1.00) 		0.716
(1.00)
Del Peak 3(2q22 1) 0.852
(1.00) 		0.597
(1.00) 		1
(1.00) 		0.901
(1.00) 		0.251
(1.00) 		0.198
(1.00) 		0.59
(1.00) 		0.417
(1.00) 		0.165
(1.00) 		1
(1.00) 		0.101
(1.00) 		0.1
(1.00) 		0.115
(1.00) 		0.624
(1.00)
Del Peak 4(2q37 3) 0.404
(1.00) 		0.881
(1.00) 		0.0736
(1.00) 		0.561
(1.00) 		0.103
(1.00) 		0.799
(1.00) 		0.0847
(1.00) 		0.244
(1.00) 		0.531
(1.00) 		0.0536
(1.00) 		0.745
(1.00) 		0.742
(1.00) 		0.253
(1.00) 		0.455
(1.00)
Del Peak 5(3p26 3) 0.989
(1.00) 		0.855
(1.00) 		0.379
(1.00) 		0.399
(1.00) 		0.616
(1.00) 		0.0033
(1.00) 		0.134
(1.00) 		0.145
(1.00) 		0.0553
(1.00) 		0.168
(1.00) 		0.712
(1.00) 		0.0563
(1.00) 		0.0346
(1.00) 		0.00238
(1.00)
Del Peak 6(3p21 31) 0.565
(1.00) 		0.39
(1.00) 		0.743
(1.00) 		0.0638
(1.00) 		0.706
(1.00) 		0.00752
(1.00) 		0.0263
(1.00) 		0.669
(1.00) 		0.198
(1.00) 		0.249
(1.00) 		0.993
(1.00) 		0.0167
(1.00) 		0.0246
(1.00) 		0.000117
(0.126)
Del Peak 7(3q11 1) 0.429
(1.00) 		0.0978
(1.00) 		0.474
(1.00) 		0.0824
(1.00) 		0.965
(1.00) 		0.798
(1.00) 		0.793
(1.00) 		0.818
(1.00) 		0.565
(1.00) 		0.802
(1.00) 		0.389
(1.00) 		0.519
(1.00) 		0.798
(1.00) 		0.019
(1.00)
Del Peak 8(3q29) 0.756
(1.00) 		0.558
(1.00) 		0.81
(1.00) 		0.367
(1.00) 		0.635
(1.00) 		0.398
(1.00) 		0.214
(1.00) 		0.652
(1.00) 		0.177
(1.00) 		0.452
(1.00) 		0.158
(1.00) 		0.652
(1.00) 		0.744
(1.00) 		0.173
(1.00)
Del Peak 9(4p15 2) 0.882
(1.00) 		0.13
(1.00) 		0.609
(1.00) 		0.871
(1.00) 		0.367
(1.00) 		0.648
(1.00) 		0.442
(1.00) 		0.785
(1.00) 		0.385
(1.00) 		0.279
(1.00) 		0.18
(1.00) 		0.000477
(0.508) 		0.0364
(1.00) 		0.197
(1.00)
Del Peak 10(4q22 1) 0.463
(1.00) 		0.716
(1.00) 		0.812
(1.00) 		0.187
(1.00) 		0.395
(1.00) 		0.367
(1.00) 		0.0344
(1.00) 		0.321
(1.00) 		0.0315
(1.00) 		0.326
(1.00) 		0.873
(1.00) 		0.323
(1.00) 		0.0939
(1.00) 		0.379
(1.00)
Del Peak 11(4q35 1) 0.756
(1.00) 		0.0877
(1.00) 		0.173
(1.00) 		0.188
(1.00) 		0.0855
(1.00) 		0.195
(1.00) 		0.243
(1.00) 		0.234
(1.00) 		0.195
(1.00) 		0.235
(1.00) 		0.683
(1.00) 		0.0878
(1.00) 		0.000979
(1.00) 		0.14
(1.00)
Del Peak 12(5q11 2) 0.289
(1.00) 		0.0299
(1.00) 		1
(1.00) 		0.47
(1.00) 		0.315
(1.00) 		0.369
(1.00) 		0.0411
(1.00) 		0.744
(1.00) 		0.138
(1.00) 		0.344
(1.00) 		0.0548
(1.00) 		0.000249
(0.266) 		0.0392
(1.00) 		0.414
(1.00)
Del Peak 13(5q34) 0.31
(1.00) 		0.0005
(0.532) 		0.304
(1.00) 		0.817
(1.00) 		0.161
(1.00) 		0.758
(1.00) 		0.201
(1.00) 		0.976
(1.00) 		0.192
(1.00) 		0.47
(1.00) 		0.069
(1.00) 		2.43e-05
(0.0261) 		1.11e-07
(0.000119) 		0.0317
(1.00)
Del Peak 14(6q12) 0.164
(1.00) 		0.667
(1.00) 		0.36
(1.00) 		0.192
(1.00) 		0.297
(1.00) 		0.733
(1.00) 		0.0351
(1.00) 		0.53
(1.00) 		0.0267
(1.00) 		0.346
(1.00) 		0.0196
(1.00) 		0.663
(1.00) 		0.0636
(1.00) 		0.104
(1.00)
Del Peak 15(6q22 31) 0.47
(1.00) 		0.264
(1.00) 		0.913
(1.00) 		0.189
(1.00) 		0.771
(1.00) 		0.65
(1.00) 		0.633
(1.00) 		0.732
(1.00) 		0.306
(1.00) 		1
(1.00) 		0.158
(1.00) 		0.16
(1.00) 		0.224
(1.00) 		0.505
(1.00)
Del Peak 16(6q26) 0.541
(1.00) 		0.138
(1.00) 		0.513
(1.00) 		0.271
(1.00) 		0.772
(1.00) 		0.945
(1.00) 		0.359
(1.00) 		0.154
(1.00) 		0.114
(1.00) 		1
(1.00) 		0.612
(1.00) 		0.271
(1.00) 		0.42
(1.00) 		0.348
(1.00)
Del Peak 17(8p23 2) 0.685
(1.00) 		0.227
(1.00) 		0.273
(1.00) 		0.0446
(1.00) 		0.0104
(1.00) 		0.257
(1.00) 		0.849
(1.00) 		0.577
(1.00) 		0.724
(1.00) 		0.363
(1.00) 		0.962
(1.00) 		0.953
(1.00) 		0.0732
(1.00) 		0.328
(1.00)
Del Peak 18(8p21 3) 0.236
(1.00) 		0.97
(1.00) 		0.125
(1.00) 		0.0494
(1.00) 		0.007
(1.00) 		0.409
(1.00) 		0.415
(1.00) 		0.163
(1.00) 		0.902
(1.00) 		0.646
(1.00) 		0.28
(1.00) 		0.196
(1.00) 		0.0983
(1.00) 		0.742
(1.00)
Del Peak 19(9p23) 0.0595
(1.00) 		0.197
(1.00) 		0.583
(1.00) 		0.614
(1.00) 		0.558
(1.00) 		0.8
(1.00) 		0.00825
(1.00) 		0.804
(1.00) 		0.417
(1.00) 		0.363
(1.00) 		0.675
(1.00) 		0.0172
(1.00) 		0.085
(1.00) 		0.322
(1.00)
Del Peak 20(9p21 3) 0.365
(1.00) 		0.0859
(1.00) 		0.0775
(1.00) 		0.821
(1.00) 		0.658
(1.00) 		0.823
(1.00) 		0.00196
(1.00) 		0.68
(1.00) 		0.115
(1.00) 		1
(1.00) 		0.746
(1.00) 		0.00172
(1.00) 		0.116
(1.00) 		0.223
(1.00)
Del Peak 21(9q21 11) 0.224
(1.00) 		0.952
(1.00) 		0.827
(1.00) 		0.908
(1.00) 		0.0274
(1.00) 		0.423
(1.00) 		0.384
(1.00) 		0.867
(1.00) 		0.577
(1.00) 		0.107
(1.00) 		0.144
(1.00) 		0.966
(1.00) 		0.274
(1.00) 		0.644
(1.00)
Del Peak 22(10p15 3) 0.155
(1.00) 		0.593
(1.00) 		6.55e-05
(0.0702) 		0.851
(1.00) 		0.516
(1.00) 		0.341
(1.00) 		0.692
(1.00) 		0.569
(1.00) 		0.894
(1.00) 		0.792
(1.00) 		0.389
(1.00) 		0.538
(1.00) 		0.00726
(1.00) 		0.734
(1.00)
Del Peak 23(10q26 3) 0.665
(1.00) 		0.963
(1.00) 		0.0359
(1.00) 		0.236
(1.00) 		0.713
(1.00) 		0.0543
(1.00) 		0.446
(1.00) 		0.948
(1.00) 		0.169
(1.00) 		0.116
(1.00) 		0.0558
(1.00) 		0.784
(1.00) 		0.0522
(1.00) 		0.0634
(1.00)
Del Peak 24(11p15 5) 0.518
(1.00) 		0.0734
(1.00) 		0.388
(1.00) 		0.318
(1.00) 		0.254
(1.00) 		0.974
(1.00) 		1
(1.00) 		0.0916
(1.00) 		0.481
(1.00) 		1
(1.00) 		0.36
(1.00) 		0.86
(1.00) 		0.00753
(1.00) 		0.239
(1.00)
Del Peak 25(11q25) 0.254
(1.00) 		0.498
(1.00) 		0.355
(1.00) 		0.535
(1.00) 		0.786
(1.00) 		0.774
(1.00) 		0.138
(1.00) 		0.525
(1.00) 		0.7
(1.00) 		0.583
(1.00) 		0.363
(1.00) 		0.963
(1.00) 		0.355
(1.00) 		0.187
(1.00)
Del Peak 26(12p13 2) 0.294
(1.00) 		0.796
(1.00) 		0.000268
(0.286) 		0.788
(1.00) 		0.79
(1.00) 		0.927
(1.00) 		0.684
(1.00) 		0.304
(1.00) 		0.407
(1.00) 		1
(1.00) 		0.0102
(1.00) 		0.591
(1.00) 		0.366
(1.00) 		0.0851
(1.00)
Del Peak 27(12q12) 0.246
(1.00) 		0.0778
(1.00) 		0.126
(1.00) 		0.693
(1.00) 		0.386
(1.00) 		0.365
(1.00) 		0.732
(1.00) 		0.148
(1.00) 		0.748
(1.00) 		0.776
(1.00) 		0.0312
(1.00) 		0.74
(1.00) 		0.963
(1.00) 		0.292
(1.00)
Del Peak 28(12q24 33) 0.505
(1.00) 		0.804
(1.00) 		0.0787
(1.00) 		0.392
(1.00) 		0.118
(1.00) 		0.0239
(1.00) 		0.763
(1.00) 		0.335
(1.00) 		0.65
(1.00) 		0.12
(1.00) 		0.154
(1.00) 		0.954
(1.00) 		0.0243
(1.00) 		0.29
(1.00)
Del Peak 29(13q12 11) 0.612
(1.00) 		0.109
(1.00) 		0.00838
(1.00) 		0.0252
(1.00) 		0.0176
(1.00) 		0.441
(1.00) 		0.981
(1.00) 		0.647
(1.00) 		0.775
(1.00) 		0.367
(1.00) 		0.0104
(1.00) 		0.234
(1.00) 		0.0174
(1.00) 		0.327
(1.00)
Del Peak 30(13q12 13) 0.728
(1.00) 		0.263
(1.00) 		0.0367
(1.00) 		0.0399
(1.00) 		0.00842
(1.00) 		0.676
(1.00) 		0.883
(1.00) 		0.647
(1.00) 		0.797
(1.00) 		0.172
(1.00) 		0.0497
(1.00) 		0.715
(1.00) 		0.0632
(1.00) 		0.322
(1.00)
Del Peak 31(13q34) 0.777
(1.00) 		0.0878
(1.00) 		0.826
(1.00) 		0.669
(1.00) 		0.245
(1.00) 		0.562
(1.00) 		1
(1.00) 		0.133
(1.00) 		0.511
(1.00) 		1
(1.00) 		0.642
(1.00) 		0.289
(1.00) 		0.093
(1.00) 		0.151
(1.00)
Del Peak 32(14q32 33) 0.411
(1.00) 		0.914
(1.00) 		1
(1.00) 		0.786
(1.00) 		0.329
(1.00) 		0.366
(1.00) 		0.341
(1.00) 		0.598
(1.00) 		0.432
(1.00) 		0.62
(1.00) 		0.0859
(1.00) 		0.904
(1.00) 		0.296
(1.00) 		0.0587
(1.00)
Del Peak 33(15q11 2) 0.328
(1.00) 		0.0601
(1.00) 		0.0793
(1.00) 		0.241
(1.00) 		0.0529
(1.00) 		0.214
(1.00) 		1
(1.00) 		0.985
(1.00) 		0.648
(1.00) 		1
(1.00) 		0.667
(1.00) 		0.233
(1.00) 		0.304
(1.00) 		0.268
(1.00)
Del Peak 34(15q15 3) 0.438
(1.00) 		0.107
(1.00) 		0.155
(1.00) 		0.241
(1.00) 		0.00567
(1.00) 		0.309
(1.00) 		0.944
(1.00) 		0.981
(1.00) 		0.826
(1.00) 		0.649
(1.00) 		0.802
(1.00) 		0.195
(1.00) 		0.112
(1.00) 		0.425
(1.00)
Del Peak 35(16q23 3) 0.942
(1.00) 		0.639
(1.00) 		0.733
(1.00) 		0.622
(1.00) 		0.607
(1.00) 		0.454
(1.00) 		0.188
(1.00) 		0.747
(1.00) 		0.442
(1.00) 		1
(1.00) 		0.456
(1.00) 		0.215
(1.00) 		0.092
(1.00) 		0.82
(1.00)
Del Peak 36(17p13 3) 0.644
(1.00) 		0.169
(1.00) 		0.187
(1.00) 		0.778
(1.00) 		0.0256
(1.00) 		0.0988
(1.00) 		0.915
(1.00) 		0.87
(1.00) 		0.897
(1.00) 		0.352
(1.00) 		0.599
(1.00) 		0.447
(1.00) 		0.222
(1.00) 		0.0231
(1.00)
Del Peak 37(18q21 32) 0.24
(1.00) 		0.307
(1.00) 		0.0638
(1.00) 		0.301
(1.00) 		0.857
(1.00) 		0.212
(1.00) 		0.245
(1.00) 		0.107
(1.00) 		0.119
(1.00) 		1
(1.00) 		0.409
(1.00) 		0.928
(1.00) 		0.395
(1.00) 		0.285
(1.00)
Del Peak 38(18q23) 0.325
(1.00) 		0.107
(1.00) 		0.0626
(1.00) 		0.318
(1.00) 		0.563
(1.00) 		0.103
(1.00) 		0.0987
(1.00) 		0.35
(1.00) 		0.0114
(1.00) 		1
(1.00) 		0.291
(1.00) 		0.585
(1.00) 		0.432
(1.00) 		0.0963
(1.00)
Del Peak 39(19p13 3) 0.046
(1.00) 		0.164
(1.00) 		0.00141
(1.00) 		0.802
(1.00) 		0.34
(1.00) 		0.179
(1.00) 		0.116
(1.00) 		0.305
(1.00) 		0.0231
(1.00) 		0.817
(1.00) 		0.3
(1.00) 		0.793
(1.00) 		0.203
(1.00) 		0.235
(1.00)
Del Peak 40(19p13 2) 0.348
(1.00) 		0.0203
(1.00) 		0.000428
(0.456) 		0.923
(1.00) 		0.463
(1.00) 		0.257
(1.00) 		0.0568
(1.00) 		0.0838
(1.00) 		0.0264
(1.00) 		0.819
(1.00) 		0.333
(1.00) 		0.655
(1.00) 		0.0329
(1.00) 		0.215
(1.00)
Del Peak 41(19q11) 0.00591
(1.00) 		0.00976
(1.00) 		1
(1.00) 		0.54
(1.00) 		0.813
(1.00) 		0.404
(1.00) 		0.0919
(1.00) 		0.315
(1.00) 		0.00761
(1.00) 		0.805
(1.00) 		0.0431
(1.00) 		0.367
(1.00) 		0.0162
(1.00) 		0.0861
(1.00)
Del Peak 42(19q13 33) 0.0382
(1.00) 		0.237
(1.00) 		0.368
(1.00) 		0.465
(1.00) 		0.164
(1.00) 		0.396
(1.00) 		0.602
(1.00) 		0.21
(1.00) 		0.286
(1.00) 		0.816
(1.00) 		0.421
(1.00) 		0.929
(1.00) 		0.275
(1.00) 		0.658
(1.00)
Del Peak 43(21q11 2) 0.612
(1.00) 		0.0606
(1.00) 		0.909
(1.00) 		0.751
(1.00) 		0.449
(1.00) 		0.631
(1.00) 		0.788
(1.00) 		0.824
(1.00) 		0.733
(1.00) 		0.346
(1.00) 		0.191
(1.00) 		0.0534
(1.00) 		0.0119
(1.00) 		0.017
(1.00)
Del Peak 44(22q13 32) 0.477
(1.00) 		0.00701
(1.00) 		0.156
(1.00) 		0.537
(1.00) 		0.184
(1.00) 		0.682
(1.00) 		0.691
(1.00) 		0.488
(1.00) 		0.493
(1.00) 		0.819
(1.00) 		0.802
(1.00) 		0.129
(1.00) 		0.000243
(0.259) 		0.00818
(1.00)
Del Peak 45(Xp22 2) 0.562
(1.00) 		0.529
(1.00) 		0.0546
(1.00) 		0.931
(1.00) 		0.644
(1.00) 		0.905
(1.00) 		0.496
(1.00) 		0.862
(1.00) 		0.969
(1.00) 		0.803
(1.00) 		0.535
(1.00) 		0.765
(1.00) 		0.545
(1.00) 		0.213
(1.00)
Clustering Approach #1: 'Amp Peak 1(1p34.3) mutation analysis'

Table S1.  Description of clustering approach #1: 'Amp Peak 1(1p34.3) mutation analysis'

Cluster Labels AMP PEAK 1(1P34.3) MUTATED AMP PEAK 1(1P34.3) WILD-TYPE
Number of samples 96 241
Clustering Approach #2: 'Amp Peak 2(1p22.3) mutation analysis'

Table S2.  Description of clustering approach #2: 'Amp Peak 2(1p22.3) mutation analysis'

Cluster Labels AMP PEAK 2(1P22.3) MUTATED AMP PEAK 2(1P22.3) WILD-TYPE
Number of samples 93 244
Clustering Approach #3: 'Amp Peak 3(1q21.3) mutation analysis'

Table S3.  Description of clustering approach #3: 'Amp Peak 3(1q21.3) mutation analysis'

Cluster Labels AMP PEAK 3(1Q21.3) MUTATED AMP PEAK 3(1Q21.3) WILD-TYPE
Number of samples 244 93
Clustering Approach #4: 'Amp Peak 4(3q26.2) mutation analysis'

Table S4.  Description of clustering approach #4: 'Amp Peak 4(3q26.2) mutation analysis'

Cluster Labels AMP PEAK 4(3Q26.2) MUTATED AMP PEAK 4(3Q26.2) WILD-TYPE
Number of samples 119 218
Clustering Approach #5: 'Amp Peak 5(4q12) mutation analysis'

Table S5.  Description of clustering approach #5: 'Amp Peak 5(4q12) mutation analysis'

Cluster Labels AMP PEAK 5(4Q12) MUTATED AMP PEAK 5(4Q12) WILD-TYPE
Number of samples 67 270
Clustering Approach #6: 'Amp Peak 6(5p15.33) mutation analysis'

Table S6.  Description of clustering approach #6: 'Amp Peak 6(5p15.33) mutation analysis'

Cluster Labels AMP PEAK 6(5P15.33) MUTATED AMP PEAK 6(5P15.33) WILD-TYPE
Number of samples 221 116
Clustering Approach #7: 'Amp Peak 7(5p13.1) mutation analysis'

Table S7.  Description of clustering approach #7: 'Amp Peak 7(5p13.1) mutation analysis'

Cluster Labels AMP PEAK 7(5P13.1) MUTATED AMP PEAK 7(5P13.1) WILD-TYPE
Number of samples 199 138
Clustering Approach #8: 'Amp Peak 8(5q35.1) mutation analysis'

Table S8.  Description of clustering approach #8: 'Amp Peak 8(5q35.1) mutation analysis'

Cluster Labels AMP PEAK 8(5Q35.1) MUTATED AMP PEAK 8(5Q35.1) WILD-TYPE
Number of samples 79 258
Clustering Approach #9: 'Amp Peak 9(6p25.3) mutation analysis'

Table S9.  Description of clustering approach #9: 'Amp Peak 9(6p25.3) mutation analysis'

Cluster Labels AMP PEAK 9(6P25.3) MUTATED AMP PEAK 9(6P25.3) WILD-TYPE
Number of samples 135 202
Clustering Approach #10: 'Amp Peak 10(6p21.1) mutation analysis'

Table S10.  Description of clustering approach #10: 'Amp Peak 10(6p21.1) mutation analysis'

Cluster Labels AMP PEAK 10(6P21.1) MUTATED AMP PEAK 10(6P21.1) WILD-TYPE
Number of samples 126 211
Clustering Approach #11: 'Amp Peak 11(7p21.1) mutation analysis'

Table S11.  Description of clustering approach #11: 'Amp Peak 11(7p21.1) mutation analysis'

Cluster Labels AMP PEAK 11(7P21.1) MUTATED AMP PEAK 11(7P21.1) WILD-TYPE
Number of samples 184 153
Clustering Approach #12: 'Amp Peak 12(7p11.2) mutation analysis'

Table S12.  Description of clustering approach #12: 'Amp Peak 12(7p11.2) mutation analysis'

Cluster Labels AMP PEAK 12(7P11.2) MUTATED AMP PEAK 12(7P11.2) WILD-TYPE
Number of samples 177 160
Clustering Approach #13: 'Amp Peak 13(7q31.2) mutation analysis'

Table S13.  Description of clustering approach #13: 'Amp Peak 13(7q31.2) mutation analysis'

Cluster Labels AMP PEAK 13(7Q31.2) MUTATED AMP PEAK 13(7Q31.2) WILD-TYPE
Number of samples 141 196
Clustering Approach #14: 'Amp Peak 14(8p11.21) mutation analysis'

Table S14.  Description of clustering approach #14: 'Amp Peak 14(8p11.21) mutation analysis'

Cluster Labels AMP PEAK 14(8P11.21) MUTATED AMP PEAK 14(8P11.21) WILD-TYPE
Number of samples 103 234
Clustering Approach #15: 'Amp Peak 15(8q11.1) mutation analysis'

Table S15.  Description of clustering approach #15: 'Amp Peak 15(8q11.1) mutation analysis'

Cluster Labels AMP PEAK 15(8Q11.1) MUTATED AMP PEAK 15(8Q11.1) WILD-TYPE
Number of samples 153 184
Clustering Approach #16: 'Amp Peak 16(8q24.21) mutation analysis'

Table S16.  Description of clustering approach #16: 'Amp Peak 16(8q24.21) mutation analysis'

Cluster Labels AMP PEAK 16(8Q24.21) MUTATED AMP PEAK 16(8Q24.21) WILD-TYPE
Number of samples 210 127
Clustering Approach #17: 'Amp Peak 17(10p15.1) mutation analysis'

Table S17.  Description of clustering approach #17: 'Amp Peak 17(10p15.1) mutation analysis'

Cluster Labels AMP PEAK 17(10P15.1) MUTATED AMP PEAK 17(10P15.1) WILD-TYPE
Number of samples 94 243
'Amp Peak 17(10p15.1) mutation analysis' versus 'STOPPEDSMOKINGYEAR'

P value = 0.000211 (t-test), Q value = 0.23

Table S18.  Clustering Approach #17: 'Amp Peak 17(10p15.1) mutation analysis' versus Clinical Feature #12: 'STOPPEDSMOKINGYEAR'

nPatients Mean (Std.Dev)
ALL 168 1994.2 (13.8)
AMP PEAK 17(10P15.1) MUTATED 48 1999.7 (10.5)
AMP PEAK 17(10P15.1) WILD-TYPE 120 1992.0 (14.4)

Figure S1.  Get High-res Image Clustering Approach #17: 'Amp Peak 17(10p15.1) mutation analysis' versus Clinical Feature #12: 'STOPPEDSMOKINGYEAR'

'Amp Peak 17(10p15.1) mutation analysis' versus 'TOBACCOSMOKINGHISTORYINDICATOR'

P value = 1.99e-06 (Fisher's exact test), Q value = 0.0021

Table S19.  Clustering Approach #17: 'Amp Peak 17(10p15.1) mutation analysis' versus Clinical Feature #13: 'TOBACCOSMOKINGHISTORYINDICATOR'

nPatients CURRENT REFORMED SMOKER FOR < OR = 15 YEARS CURRENT REFORMED SMOKER FOR > 15 YEARS CURRENT SMOKER LIFELONG NON-SMOKER
ALL 114 86 76 48
AMP PEAK 17(10P15.1) MUTATED 43 16 28 2
AMP PEAK 17(10P15.1) WILD-TYPE 71 70 48 46

Figure S2.  Get High-res Image Clustering Approach #17: 'Amp Peak 17(10p15.1) mutation analysis' versus Clinical Feature #13: 'TOBACCOSMOKINGHISTORYINDICATOR'

Clustering Approach #18: 'Amp Peak 18(11q13.3) mutation analysis'

Table S20.  Description of clustering approach #18: 'Amp Peak 18(11q13.3) mutation analysis'

Cluster Labels AMP PEAK 18(11Q13.3) MUTATED AMP PEAK 18(11Q13.3) WILD-TYPE
Number of samples 119 218
'Amp Peak 18(11q13.3) mutation analysis' versus 'AGE'

P value = 3.36e-05 (t-test), Q value = 0.036

Table S21.  Clustering Approach #18: 'Amp Peak 18(11q13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

nPatients Mean (Std.Dev)
ALL 306 65.2 (9.9)
AMP PEAK 18(11Q13.3) MUTATED 110 62.2 (9.6)
AMP PEAK 18(11Q13.3) WILD-TYPE 196 67.0 (9.6)

Figure S3.  Get High-res Image Clustering Approach #18: 'Amp Peak 18(11q13.3) mutation analysis' versus Clinical Feature #2: 'AGE'

Clustering Approach #19: 'Amp Peak 19(12p12.1) mutation analysis'

Table S22.  Description of clustering approach #19: 'Amp Peak 19(12p12.1) mutation analysis'

Cluster Labels AMP PEAK 19(12P12.1) MUTATED AMP PEAK 19(12P12.1) WILD-TYPE
Number of samples 119 218
Clustering Approach #20: 'Amp Peak 20(12q14.1) mutation analysis'

Table S23.  Description of clustering approach #20: 'Amp Peak 20(12q14.1) mutation analysis'

Cluster Labels AMP PEAK 20(12Q14.1) MUTATED AMP PEAK 20(12Q14.1) WILD-TYPE
Number of samples 107 230
Clustering Approach #21: 'Amp Peak 21(12q15) mutation analysis'

Table S24.  Description of clustering approach #21: 'Amp Peak 21(12q15) mutation analysis'

Cluster Labels AMP PEAK 21(12Q15) MUTATED AMP PEAK 21(12Q15) WILD-TYPE
Number of samples 110 227
Clustering Approach #22: 'Amp Peak 22(13q33.3) mutation analysis'

Table S25.  Description of clustering approach #22: 'Amp Peak 22(13q33.3) mutation analysis'

Cluster Labels AMP PEAK 22(13Q33.3) MUTATED AMP PEAK 22(13Q33.3) WILD-TYPE
Number of samples 56 281
Clustering Approach #23: 'Amp Peak 23(14q13.3) mutation analysis'

Table S26.  Description of clustering approach #23: 'Amp Peak 23(14q13.3) mutation analysis'

Cluster Labels AMP PEAK 23(14Q13.3) MUTATED AMP PEAK 23(14Q13.3) WILD-TYPE
Number of samples 148 189
Clustering Approach #24: 'Amp Peak 24(17q12) mutation analysis'

Table S27.  Description of clustering approach #24: 'Amp Peak 24(17q12) mutation analysis'

Cluster Labels AMP PEAK 24(17Q12) MUTATED AMP PEAK 24(17Q12) WILD-TYPE
Number of samples 153 184
Clustering Approach #25: 'Amp Peak 25(17q23.1) mutation analysis'

Table S28.  Description of clustering approach #25: 'Amp Peak 25(17q23.1) mutation analysis'

Cluster Labels AMP PEAK 25(17Q23.1) MUTATED AMP PEAK 25(17Q23.1) WILD-TYPE
Number of samples 164 173
Clustering Approach #26: 'Amp Peak 26(18p11.32) mutation analysis'

Table S29.  Description of clustering approach #26: 'Amp Peak 26(18p11.32) mutation analysis'

Cluster Labels AMP PEAK 26(18P11.32) MUTATED AMP PEAK 26(18P11.32) WILD-TYPE
Number of samples 89 248
Clustering Approach #27: 'Amp Peak 27(18q11.2) mutation analysis'

Table S30.  Description of clustering approach #27: 'Amp Peak 27(18q11.2) mutation analysis'

Cluster Labels AMP PEAK 27(18Q11.2) MUTATED AMP PEAK 27(18Q11.2) WILD-TYPE
Number of samples 72 265
Clustering Approach #28: 'Amp Peak 28(19q12) mutation analysis'

Table S31.  Description of clustering approach #28: 'Amp Peak 28(19q12) mutation analysis'

Cluster Labels AMP PEAK 28(19Q12) MUTATED AMP PEAK 28(19Q12) WILD-TYPE
Number of samples 93 244
Clustering Approach #29: 'Amp Peak 29(20q11.21) mutation analysis'

Table S32.  Description of clustering approach #29: 'Amp Peak 29(20q11.21) mutation analysis'

Cluster Labels AMP PEAK 29(20Q11.21) MUTATED AMP PEAK 29(20Q11.21) WILD-TYPE
Number of samples 147 190
Clustering Approach #30: 'Amp Peak 30(20q13.33) mutation analysis'

Table S33.  Description of clustering approach #30: 'Amp Peak 30(20q13.33) mutation analysis'

Cluster Labels AMP PEAK 30(20Q13.33) MUTATED AMP PEAK 30(20Q13.33) WILD-TYPE
Number of samples 164 173
Clustering Approach #31: 'Amp Peak 31(22q11.22) mutation analysis'

Table S34.  Description of clustering approach #31: 'Amp Peak 31(22q11.22) mutation analysis'

Cluster Labels AMP PEAK 31(22Q11.22) MUTATED AMP PEAK 31(22Q11.22) WILD-TYPE
Number of samples 56 281
Clustering Approach #32: 'Amp Peak 32(Xq28) mutation analysis'

Table S35.  Description of clustering approach #32: 'Amp Peak 32(Xq28) mutation analysis'

Cluster Labels AMP PEAK 32(XQ28) MUTATED AMP PEAK 32(XQ28) WILD-TYPE
Number of samples 113 224
Clustering Approach #33: 'Del Peak 1(1p36.13) mutation analysis'

Table S36.  Description of clustering approach #33: 'Del Peak 1(1p36.13) mutation analysis'

Cluster Labels DEL PEAK 1(1P36.13) MUTATED DEL PEAK 1(1P36.13) WILD-TYPE
Number of samples 78 259
Clustering Approach #34: 'Del Peak 2(1p13.1) mutation analysis'

Table S37.  Description of clustering approach #34: 'Del Peak 2(1p13.1) mutation analysis'

Cluster Labels DEL PEAK 2(1P13.1) MUTATED DEL PEAK 2(1P13.1) WILD-TYPE
Number of samples 100 237
Clustering Approach #35: 'Del Peak 3(2q22.1) mutation analysis'

Table S38.  Description of clustering approach #35: 'Del Peak 3(2q22.1) mutation analysis'

Cluster Labels DEL PEAK 3(2Q22.1) MUTATED DEL PEAK 3(2Q22.1) WILD-TYPE
Number of samples 37 300
Clustering Approach #36: 'Del Peak 4(2q37.3) mutation analysis'

Table S39.  Description of clustering approach #36: 'Del Peak 4(2q37.3) mutation analysis'

Cluster Labels DEL PEAK 4(2Q37.3) MUTATED DEL PEAK 4(2Q37.3) WILD-TYPE
Number of samples 54 283
Clustering Approach #37: 'Del Peak 5(3p26.3) mutation analysis'

Table S40.  Description of clustering approach #37: 'Del Peak 5(3p26.3) mutation analysis'

Cluster Labels DEL PEAK 5(3P26.3) MUTATED DEL PEAK 5(3P26.3) WILD-TYPE
Number of samples 155 182
Clustering Approach #38: 'Del Peak 6(3p21.31) mutation analysis'

Table S41.  Description of clustering approach #38: 'Del Peak 6(3p21.31) mutation analysis'

Cluster Labels DEL PEAK 6(3P21.31) MUTATED DEL PEAK 6(3P21.31) WILD-TYPE
Number of samples 167 170
'Del Peak 6(3p21.31) mutation analysis' versus 'YEAROFTOBACCOSMOKINGONSET'

P value = 0.000117 (t-test), Q value = 0.13

Table S42.  Clustering Approach #38: 'Del Peak 6(3p21.31) mutation analysis' versus Clinical Feature #14: 'YEAROFTOBACCOSMOKINGONSET'

nPatients Mean (Std.Dev)
ALL 169 1965.0 (13.0)
DEL PEAK 6(3P21.31) MUTATED 84 1968.8 (12.8)
DEL PEAK 6(3P21.31) WILD-TYPE 85 1961.3 (12.0)

Figure S4.  Get High-res Image Clustering Approach #38: 'Del Peak 6(3p21.31) mutation analysis' versus Clinical Feature #14: 'YEAROFTOBACCOSMOKINGONSET'

Clustering Approach #39: 'Del Peak 7(3q11.1) mutation analysis'

Table S43.  Description of clustering approach #39: 'Del Peak 7(3q11.1) mutation analysis'

Cluster Labels DEL PEAK 7(3Q11.1) MUTATED DEL PEAK 7(3Q11.1) WILD-TYPE
Number of samples 101 236
Clustering Approach #40: 'Del Peak 8(3q29) mutation analysis'

Table S44.  Description of clustering approach #40: 'Del Peak 8(3q29) mutation analysis'

Cluster Labels DEL PEAK 8(3Q29) MUTATED DEL PEAK 8(3Q29) WILD-TYPE
Number of samples 98 239
Clustering Approach #41: 'Del Peak 9(4p15.2) mutation analysis'

Table S45.  Description of clustering approach #41: 'Del Peak 9(4p15.2) mutation analysis'

Cluster Labels DEL PEAK 9(4P15.2) MUTATED DEL PEAK 9(4P15.2) WILD-TYPE
Number of samples 81 256
Clustering Approach #42: 'Del Peak 10(4q22.1) mutation analysis'

Table S46.  Description of clustering approach #42: 'Del Peak 10(4q22.1) mutation analysis'

Cluster Labels DEL PEAK 10(4Q22.1) MUTATED DEL PEAK 10(4Q22.1) WILD-TYPE
Number of samples 102 235
Clustering Approach #43: 'Del Peak 11(4q35.1) mutation analysis'

Table S47.  Description of clustering approach #43: 'Del Peak 11(4q35.1) mutation analysis'

Cluster Labels DEL PEAK 11(4Q35.1) MUTATED DEL PEAK 11(4Q35.1) WILD-TYPE
Number of samples 124 213
Clustering Approach #44: 'Del Peak 12(5q11.2) mutation analysis'

Table S48.  Description of clustering approach #44: 'Del Peak 12(5q11.2) mutation analysis'

Cluster Labels DEL PEAK 12(5Q11.2) MUTATED DEL PEAK 12(5Q11.2) WILD-TYPE
Number of samples 122 215
Clustering Approach #45: 'Del Peak 13(5q34) mutation analysis'

Table S49.  Description of clustering approach #45: 'Del Peak 13(5q34) mutation analysis'

Cluster Labels DEL PEAK 13(5Q34) MUTATED DEL PEAK 13(5Q34) WILD-TYPE
Number of samples 119 218
'Del Peak 13(5q34) mutation analysis' versus 'STOPPEDSMOKINGYEAR'

P value = 2.43e-05 (t-test), Q value = 0.026

Table S50.  Clustering Approach #45: 'Del Peak 13(5q34) mutation analysis' versus Clinical Feature #12: 'STOPPEDSMOKINGYEAR'

nPatients Mean (Std.Dev)
ALL 168 1994.2 (13.8)
DEL PEAK 13(5Q34) MUTATED 52 2000.0 (10.1)
DEL PEAK 13(5Q34) WILD-TYPE 116 1991.6 (14.4)

Figure S5.  Get High-res Image Clustering Approach #45: 'Del Peak 13(5q34) mutation analysis' versus Clinical Feature #12: 'STOPPEDSMOKINGYEAR'

'Del Peak 13(5q34) mutation analysis' versus 'TOBACCOSMOKINGHISTORYINDICATOR'

P value = 1.11e-07 (Fisher's exact test), Q value = 0.00012

Table S51.  Clustering Approach #45: 'Del Peak 13(5q34) mutation analysis' versus Clinical Feature #13: 'TOBACCOSMOKINGHISTORYINDICATOR'

nPatients CURRENT REFORMED SMOKER FOR < OR = 15 YEARS CURRENT REFORMED SMOKER FOR > 15 YEARS CURRENT SMOKER LIFELONG NON-SMOKER
ALL 114 86 76 48
DEL PEAK 13(5Q34) MUTATED 47 16 44 9
DEL PEAK 13(5Q34) WILD-TYPE 67 70 32 39

Figure S6.  Get High-res Image Clustering Approach #45: 'Del Peak 13(5q34) mutation analysis' versus Clinical Feature #13: 'TOBACCOSMOKINGHISTORYINDICATOR'

Clustering Approach #46: 'Del Peak 14(6q12) mutation analysis'

Table S52.  Description of clustering approach #46: 'Del Peak 14(6q12) mutation analysis'

Cluster Labels DEL PEAK 14(6Q12) MUTATED DEL PEAK 14(6Q12) WILD-TYPE
Number of samples 119 218
Clustering Approach #47: 'Del Peak 15(6q22.31) mutation analysis'

Table S53.  Description of clustering approach #47: 'Del Peak 15(6q22.31) mutation analysis'

Cluster Labels DEL PEAK 15(6Q22.31) MUTATED DEL PEAK 15(6Q22.31) WILD-TYPE
Number of samples 172 165
Clustering Approach #48: 'Del Peak 16(6q26) mutation analysis'

Table S54.  Description of clustering approach #48: 'Del Peak 16(6q26) mutation analysis'

Cluster Labels DEL PEAK 16(6Q26) MUTATED DEL PEAK 16(6Q26) WILD-TYPE
Number of samples 174 163
Clustering Approach #49: 'Del Peak 17(8p23.2) mutation analysis'

Table S55.  Description of clustering approach #49: 'Del Peak 17(8p23.2) mutation analysis'

Cluster Labels DEL PEAK 17(8P23.2) MUTATED DEL PEAK 17(8P23.2) WILD-TYPE
Number of samples 166 171
Clustering Approach #50: 'Del Peak 18(8p21.3) mutation analysis'

Table S56.  Description of clustering approach #50: 'Del Peak 18(8p21.3) mutation analysis'

Cluster Labels DEL PEAK 18(8P21.3) MUTATED DEL PEAK 18(8P21.3) WILD-TYPE
Number of samples 179 158
Clustering Approach #51: 'Del Peak 19(9p23) mutation analysis'

Table S57.  Description of clustering approach #51: 'Del Peak 19(9p23) mutation analysis'

Cluster Labels DEL PEAK 19(9P23) MUTATED DEL PEAK 19(9P23) WILD-TYPE
Number of samples 183 154
Clustering Approach #52: 'Del Peak 20(9p21.3) mutation analysis'

Table S58.  Description of clustering approach #52: 'Del Peak 20(9p21.3) mutation analysis'

Cluster Labels DEL PEAK 20(9P21.3) MUTATED DEL PEAK 20(9P21.3) WILD-TYPE
Number of samples 189 148
Clustering Approach #53: 'Del Peak 21(9q21.11) mutation analysis'

Table S59.  Description of clustering approach #53: 'Del Peak 21(9q21.11) mutation analysis'

Cluster Labels DEL PEAK 21(9Q21.11) MUTATED DEL PEAK 21(9Q21.11) WILD-TYPE
Number of samples 164 173
Clustering Approach #54: 'Del Peak 22(10p15.3) mutation analysis'

Table S60.  Description of clustering approach #54: 'Del Peak 22(10p15.3) mutation analysis'

Cluster Labels DEL PEAK 22(10P15.3) MUTATED DEL PEAK 22(10P15.3) WILD-TYPE
Number of samples 82 255
'Del Peak 22(10p15.3) mutation analysis' versus 'GENDER'

P value = 6.55e-05 (Fisher's exact test), Q value = 0.07

Table S61.  Clustering Approach #54: 'Del Peak 22(10p15.3) mutation analysis' versus Clinical Feature #3: 'GENDER'

nPatients FEMALE MALE
ALL 186 151
DEL PEAK 22(10P15.3) MUTATED 61 21
DEL PEAK 22(10P15.3) WILD-TYPE 125 130

Figure S7.  Get High-res Image Clustering Approach #54: 'Del Peak 22(10p15.3) mutation analysis' versus Clinical Feature #3: 'GENDER'

Clustering Approach #55: 'Del Peak 23(10q26.3) mutation analysis'

Table S62.  Description of clustering approach #55: 'Del Peak 23(10q26.3) mutation analysis'

Cluster Labels DEL PEAK 23(10Q26.3) MUTATED DEL PEAK 23(10Q26.3) WILD-TYPE
Number of samples 91 246
Clustering Approach #56: 'Del Peak 24(11p15.5) mutation analysis'

Table S63.  Description of clustering approach #56: 'Del Peak 24(11p15.5) mutation analysis'

Cluster Labels DEL PEAK 24(11P15.5) MUTATED DEL PEAK 24(11P15.5) WILD-TYPE
Number of samples 90 247
Clustering Approach #57: 'Del Peak 25(11q25) mutation analysis'

Table S64.  Description of clustering approach #57: 'Del Peak 25(11q25) mutation analysis'

Cluster Labels DEL PEAK 25(11Q25) MUTATED DEL PEAK 25(11Q25) WILD-TYPE
Number of samples 74 263
Clustering Approach #58: 'Del Peak 26(12p13.2) mutation analysis'

Table S65.  Description of clustering approach #58: 'Del Peak 26(12p13.2) mutation analysis'

Cluster Labels DEL PEAK 26(12P13.2) MUTATED DEL PEAK 26(12P13.2) WILD-TYPE
Number of samples 96 241
Clustering Approach #59: 'Del Peak 27(12q12) mutation analysis'

Table S66.  Description of clustering approach #59: 'Del Peak 27(12q12) mutation analysis'

Cluster Labels DEL PEAK 27(12Q12) MUTATED DEL PEAK 27(12Q12) WILD-TYPE
Number of samples 64 273
Clustering Approach #60: 'Del Peak 28(12q24.33) mutation analysis'

Table S67.  Description of clustering approach #60: 'Del Peak 28(12q24.33) mutation analysis'

Cluster Labels DEL PEAK 28(12Q24.33) MUTATED DEL PEAK 28(12Q24.33) WILD-TYPE
Number of samples 85 252
Clustering Approach #61: 'Del Peak 29(13q12.11) mutation analysis'

Table S68.  Description of clustering approach #61: 'Del Peak 29(13q12.11) mutation analysis'

Cluster Labels DEL PEAK 29(13Q12.11) MUTATED DEL PEAK 29(13Q12.11) WILD-TYPE
Number of samples 185 152
Clustering Approach #62: 'Del Peak 30(13q12.13) mutation analysis'

Table S69.  Description of clustering approach #62: 'Del Peak 30(13q12.13) mutation analysis'

Cluster Labels DEL PEAK 30(13Q12.13) MUTATED DEL PEAK 30(13Q12.13) WILD-TYPE
Number of samples 186 151
Clustering Approach #63: 'Del Peak 31(13q34) mutation analysis'

Table S70.  Description of clustering approach #63: 'Del Peak 31(13q34) mutation analysis'

Cluster Labels DEL PEAK 31(13Q34) MUTATED DEL PEAK 31(13Q34) WILD-TYPE
Number of samples 151 186
Clustering Approach #64: 'Del Peak 32(14q32.33) mutation analysis'

Table S71.  Description of clustering approach #64: 'Del Peak 32(14q32.33) mutation analysis'

Cluster Labels DEL PEAK 32(14Q32.33) MUTATED DEL PEAK 32(14Q32.33) WILD-TYPE
Number of samples 101 236
Clustering Approach #65: 'Del Peak 33(15q11.2) mutation analysis'

Table S72.  Description of clustering approach #65: 'Del Peak 33(15q11.2) mutation analysis'

Cluster Labels DEL PEAK 33(15Q11.2) MUTATED DEL PEAK 33(15Q11.2) WILD-TYPE
Number of samples 175 162
Clustering Approach #66: 'Del Peak 34(15q15.3) mutation analysis'

Table S73.  Description of clustering approach #66: 'Del Peak 34(15q15.3) mutation analysis'

Cluster Labels DEL PEAK 34(15Q15.3) MUTATED DEL PEAK 34(15Q15.3) WILD-TYPE
Number of samples 182 155
Clustering Approach #67: 'Del Peak 35(16q23.3) mutation analysis'

Table S74.  Description of clustering approach #67: 'Del Peak 35(16q23.3) mutation analysis'

Cluster Labels DEL PEAK 35(16Q23.3) MUTATED DEL PEAK 35(16Q23.3) WILD-TYPE
Number of samples 123 214
Clustering Approach #68: 'Del Peak 36(17p13.3) mutation analysis'

Table S75.  Description of clustering approach #68: 'Del Peak 36(17p13.3) mutation analysis'

Cluster Labels DEL PEAK 36(17P13.3) MUTATED DEL PEAK 36(17P13.3) WILD-TYPE
Number of samples 192 145
Clustering Approach #69: 'Del Peak 37(18q21.32) mutation analysis'

Table S76.  Description of clustering approach #69: 'Del Peak 37(18q21.32) mutation analysis'

Cluster Labels DEL PEAK 37(18Q21.32) MUTATED DEL PEAK 37(18Q21.32) WILD-TYPE
Number of samples 173 164
Clustering Approach #70: 'Del Peak 38(18q23) mutation analysis'

Table S77.  Description of clustering approach #70: 'Del Peak 38(18q23) mutation analysis'

Cluster Labels DEL PEAK 38(18Q23) MUTATED DEL PEAK 38(18Q23) WILD-TYPE
Number of samples 167 170
Clustering Approach #71: 'Del Peak 39(19p13.3) mutation analysis'

Table S78.  Description of clustering approach #71: 'Del Peak 39(19p13.3) mutation analysis'

Cluster Labels DEL PEAK 39(19P13.3) MUTATED DEL PEAK 39(19P13.3) WILD-TYPE
Number of samples 186 151
Clustering Approach #72: 'Del Peak 40(19p13.2) mutation analysis'

Table S79.  Description of clustering approach #72: 'Del Peak 40(19p13.2) mutation analysis'

Cluster Labels DEL PEAK 40(19P13.2) MUTATED DEL PEAK 40(19P13.2) WILD-TYPE
Number of samples 180 157
Clustering Approach #73: 'Del Peak 41(19q11) mutation analysis'

Table S80.  Description of clustering approach #73: 'Del Peak 41(19q11) mutation analysis'

Cluster Labels DEL PEAK 41(19Q11) MUTATED DEL PEAK 41(19Q11) WILD-TYPE
Number of samples 96 241
Clustering Approach #74: 'Del Peak 42(19q13.33) mutation analysis'

Table S81.  Description of clustering approach #74: 'Del Peak 42(19q13.33) mutation analysis'

Cluster Labels DEL PEAK 42(19Q13.33) MUTATED DEL PEAK 42(19Q13.33) WILD-TYPE
Number of samples 127 210
Clustering Approach #75: 'Del Peak 43(21q11.2) mutation analysis'

Table S82.  Description of clustering approach #75: 'Del Peak 43(21q11.2) mutation analysis'

Cluster Labels DEL PEAK 43(21Q11.2) MUTATED DEL PEAK 43(21Q11.2) WILD-TYPE
Number of samples 119 218
Clustering Approach #76: 'Del Peak 44(22q13.32) mutation analysis'

Table S83.  Description of clustering approach #76: 'Del Peak 44(22q13.32) mutation analysis'

Cluster Labels DEL PEAK 44(22Q13.32) MUTATED DEL PEAK 44(22Q13.32) WILD-TYPE
Number of samples 166 171
Clustering Approach #77: 'Del Peak 45(Xp22.2) mutation analysis'

Table S84.  Description of clustering approach #77: 'Del Peak 45(Xp22.2) mutation analysis'

Cluster Labels DEL PEAK 45(XP22.2) MUTATED DEL PEAK 45(XP22.2) WILD-TYPE
Number of samples 98 239
Methods & Data
Input

  • Cluster data file = all_lesions.conf_99.cnv.cluster.txt

  • Clinical data file = LUAD-TP.clin.merged.picked.txt

  • Number of patients = 337

  • Number of clustering approaches = 77

  • Number of selected clinical features = 14

  • Exclude small clusters that include fewer than K patients, K = 3

Survival analysis

For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R

Student's t-test analysis

For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between two tumor subtypes using 't.test' function in R

Fisher's exact test

For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References
[1] Bland and Altman, Statistics notes: The logrank test, BMJ 328(7447):1073 (2004)
[2] Lehmann and Romano, Testing Statistical Hypotheses (3E ed.), New York: Springer. ISBN 0387988645 (2005)
[3] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)
[4] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)
[5] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)
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