Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.209 0.245 -9999.0 0.0 -0.635 62.0 62.0 IHH -0.311 0.271 -9999.0 0.0 -0.544 202.0 202.0 SHH Np/Cholesterol/GAS1 -0.044 0.105 -9999.0 0.0 -0.281 55.0 55.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.104 0.279 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.21 0.214 -9999.0 0.0 -0.494 74.0 74.0 SMO -0.226 0.225 -9999.0 0.0 -0.396 201.0 201.0 AKT1 -0.092 0.103 -9999.0 0.0 -0.281 11.0 11.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.028 -9999.0 0.0 -0.523 1.0 1.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.223 0.221 -9999.0 0.0 -0.391 201.0 201.0 STIL -0.201 0.22 -9999.0 0.0 -0.481 103.0 103.0 DHH N/PTCH2 -0.024 0.09 -9999.0 0.0 -0.356 24.0 24.0 DHH N/PTCH1 -0.188 0.19 -9999.0 0.0 -0.476 67.0 67.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.024 0.127 -9999.0 0.0 -0.504 23.0 23.0 PTHLH -0.275 0.29 -9999.0 0.0 -0.773 62.0 62.0 determination of left/right symmetry -0.223 0.221 -9999.0 0.0 -0.391 201.0 201.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.272 0.286 -9999.0 0.0 -0.764 62.0 62.0 IHH N/Hhip -0.378 0.253 -9999.0 0.0 -0.495 272.0 272.0 DHH N/Hhip -0.22 0.198 -9999.0 0.0 -0.38 204.0 204.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.223 0.221 -9999.0 0.0 -0.391 201.0 201.0 pancreas development -0.277 0.254 -9999.0 0.0 -0.503 197.0 197.0 HHAT 0.007 0.039 -9999.0 0.0 -0.504 2.0 2.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.089 -9999.0 0.0 -0.504 11.0 11.0 somite specification -0.223 0.221 -9999.0 0.0 -0.391 201.0 201.0 SHH Np/Cholesterol/PTCH1 -0.177 0.193 -9999.0 0.0 -0.455 81.0 81.0 SHH Np/Cholesterol/PTCH2 -0.036 0.091 -9999.0 0.0 -0.267 48.0 48.0 SHH Np/Cholesterol/Megalin -0.107 0.153 -9999.0 0.0 -0.301 126.0 126.0 SHH -0.032 0.127 -9999.0 0.0 -0.357 47.0 47.0 catabolic process -0.198 0.197 -9999.0 0.0 -0.339 207.0 207.0 SMO/Vitamin D3 -0.201 0.214 -9999.0 0.0 -0.498 81.0 81.0 SHH Np/Cholesterol/Hhip -0.184 0.165 -9999.0 0.0 -0.304 214.0 214.0 LRP2 -0.129 0.228 -9999.0 0.0 -0.504 95.0 95.0 receptor-mediated endocytosis -0.257 0.225 -9999.0 0.0 -0.513 125.0 125.0 SHH Np/Cholesterol/BOC -0.036 0.091 -9999.0 0.0 -0.267 48.0 48.0 SHH Np/Cholesterol/CDO -0.042 0.101 -9999.0 0.0 -0.277 53.0 53.0 mesenchymal cell differentiation 0.183 0.164 0.302 214.0 -9999.0 0.0 214.0 mol:Vitamin D3 -0.177 0.195 -9999.0 0.0 -0.458 81.0 81.0 IHH N/PTCH2 -0.179 0.167 -9999.0 0.0 -0.32 202.0 202.0 CDON -0.002 0.076 -9999.0 0.0 -0.504 8.0 8.0 IHH N/PTCH1 -0.2 0.199 -9999.0 0.0 -0.342 207.0 207.0 Megalin/LRPAP1 -0.096 0.158 -9999.0 0.0 -0.356 95.0 95.0 PTCH2 0.008 0.027 -9999.0 0.0 -0.504 1.0 1.0 SHH Np/Cholesterol -0.036 0.093 -9999.0 0.0 -0.273 47.0 47.0 PTCH1 -0.199 0.198 -9999.0 0.0 -0.34 207.0 207.0 HHIP -0.277 0.255 -9999.0 0.0 -0.504 197.0 197.0