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MAF used for this analysis:PRAD-TP.final_analysis_set.maf
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Significantly mutated genes (q ≤ 0.1): 11
Column Descriptions:
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N = number of sequenced bases in this gene across the individual set
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nnon = number of (nonsilent) mutations in this gene across the individual set
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nnull = number of (nonsilent) null mutations in this gene across the individual set
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nflank = number of noncoding mutations from this gene's flanking region, across the individual set
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nsil = number of silent mutations in this gene across the individual set
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p = p-value (overall)
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q = q-value, False Discovery Rate (Benjamini-Hochberg procedure)
Table 1. Get Full Table A Ranked List of Significantly Mutated Genes. Number of significant genes found: 11. Number of genes displayed: 35. Click on a gene name to display its stick figure depicting the distribution of mutations and mutation types across the chosen gene (this feature may not be available for all significant genes).
| gene | N | nflank | nsil | nnon | nnull | p | q |
|---|---|---|---|---|---|---|---|
| NKX3-1 | 4482 | 0 | 0 | 5 | 1 | 2.6e-114 | 4.9e-110 |
| MLL3 | 134211 | 0 | 0 | 10 | 7 | 1.4e-76 | 1.3e-72 |
| TP53 | 10458 | 0 | 0 | 5 | 1 | 1.6e-49 | 1e-45 |
| SPOP | 11371 | 0 | 0 | 4 | 0 | 2e-27 | 9.4e-24 |
| ZMYM3 | 30544 | 0 | 0 | 5 | 3 | 1.9e-17 | 7.1e-14 |
| MUC4 | 51875 | 0 | 2 | 5 | 0 | 1.4e-10 | 4.4e-07 |
| YBX1 | 6723 | 0 | 0 | 4 | 0 | 2e-10 | 5.3e-07 |
| FRG1 | 8715 | 0 | 0 | 4 | 1 | 3.1e-08 | 0.000072 |
| CNTNAP5 | 35856 | 0 | 0 | 5 | 1 | 1.7e-07 | 0.00035 |
| ATM | 100098 | 0 | 0 | 5 | 0 | 7.8e-06 | 0.015 |
| TTN | 1058084 | 0 | 4 | 18 | 4 | 0.000039 | 0.067 |
| FAT1 | 135124 | 0 | 1 | 5 | 0 | 0.00017 | 0.26 |
| LRP1B | 142345 | 0 | 1 | 5 | 1 | 0.0014 | 1 |
| CROCC | 23987 | 0 | 1 | 4 | 0 | 0.0018 | 1 |
| AHNAK2 | 141681 | 0 | 2 | 7 | 0 | 0.0023 | 1 |
| LPHN3 | 35275 | 0 | 1 | 4 | 0 | 0.013 | 1 |
| INADL | 52539 | 0 | 0 | 4 | 1 | 0.055 | 1 |
| MUC16 | 383377 | 0 | 4 | 9 | 0 | 0.06 | 1 |
| PRR21 | 5229 | 0 | 0 | 4 | 0 | 0.1 | 1 |
| RP1 | 67562 | 0 | 0 | 4 | 1 | 0.1 | 1 |
| SETD5 | 35441 | 0 | 1 | 4 | 0 | 0.12 | 1 |
| HSPG2 | 86735 | 0 | 1 | 4 | 0 | 0.17 | 1 |
| ASH1L | 87482 | 0 | 0 | 4 | 2 | 0.18 | 1 |
| GRID2 | 30793 | 0 | 1 | 4 | 0 | 0.18 | 1 |
| DMXL2 | 89723 | 0 | 0 | 4 | 3 | 0.18 | 1 |
| FCGBP | 81423 | 0 | 1 | 5 | 0 | 0.23 | 1 |
| MUC17 | 112548 | 0 | 1 | 5 | 0 | 0.25 | 1 |
| CSMD3 | 110224 | 0 | 1 | 4 | 2 | 0.3 | 1 |
| SYNE1 | 272323 | 0 | 1 | 5 | 0 | 0.54 | 1 |
| FZD2 | 14359 | 0 | 4 | 4 | 1 | 0.86 | 1 |
| FAT4 | 143839 | 0 | 3 | 4 | 1 | 0.87 | 1 |
| AGT | 13114 | 0 | 0 | 3 | 0 | 1 | 1 |
| AIM2 | 11537 | 0 | 0 | 3 | 1 | 1 | 1 |
| ANK2 | 110058 | 0 | 0 | 3 | 0 | 1 | 1 |
| ANO4 | 30295 | 0 | 0 | 3 | 0 | 1 | 1 |
