Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	16.0	116.0	7.0	-0.14	0.004	1000.0	-1000.0	-0.016	-1000.0
IL4-mediated signaling events	11.0	1061.0	91.0	-0.639	0.57	1000.0	-1000.0	-0.175	-1000.0
IL23-mediated signaling events	10.0	649.0	60.0	-0.522	0.012	1000.0	-1000.0	-0.164	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	412.0	44.0	-0.159	0.012	1000.0	-1000.0	-0.037	-1000.0
Wnt signaling	9.0	68.0	7.0	-0.101	-0.003	1000.0	-1000.0	-0.022	-1000.0
IL12-mediated signaling events	7.0	650.0	87.0	-0.29	0.078	1000.0	-1000.0	-0.14	-1000.0
Signaling events mediated by the Hedgehog family	7.0	404.0	52.0	-0.137	0.088	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	7.0	348.0	46.0	-0.419	0.017	1000.0	-1000.0	-0.111	-1000.0
Endothelins	7.0	707.0	96.0	-0.145	0.012	1000.0	-1000.0	-0.074	-1000.0
TCGA08_p53	7.0	51.0	7.0	-0.052	0.023	1000.0	-1000.0	-0.01	-1000.0
Syndecan-4-mediated signaling events	7.0	524.0	67.0	-0.151	0.026	1000.0	-1000.0	-0.058	-1000.0
Syndecan-1-mediated signaling events	6.0	225.0	34.0	-0.128	0.012	1000.0	-1000.0	-0.045	-1000.0
Noncanonical Wnt signaling pathway	6.0	175.0	26.0	-0.101	0.012	1000.0	-1000.0	-0.042	-1000.0
HIF-1-alpha transcription factor network	6.0	466.0	76.0	-0.314	0.018	1000.0	-1000.0	-0.168	-1000.0
Glypican 1 network	6.0	309.0	48.0	-0.146	0.019	1000.0	-1000.0	-0.029	-1000.0
amb2 Integrin signaling	6.0	557.0	82.0	-0.146	0.012	1000.0	-1000.0	-0.063	-1000.0
Ephrin B reverse signaling	6.0	312.0	48.0	-0.175	0.045	1000.0	-1000.0	-0.048	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	622.0	93.0	-0.11	0.025	1000.0	-1000.0	-0.065	-1000.0
BCR signaling pathway	6.0	652.0	99.0	-0.145	0.022	1000.0	-1000.0	-0.068	-1000.0
Thromboxane A2 receptor signaling	5.0	606.0	105.0	-0.143	0.05	1000.0	-1000.0	-0.053	-1000.0
BMP receptor signaling	5.0	480.0	81.0	-0.16	0.024	1000.0	-1000.0	-0.072	-1000.0
Fc-epsilon receptor I signaling in mast cells	5.0	565.0	97.0	-0.127	0.03	1000.0	-1000.0	-0.067	-1000.0
Glucocorticoid receptor regulatory network	5.0	654.0	114.0	-0.365	0.253	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	5.0	299.0	58.0	-0.169	0.012	1000.0	-1000.0	-0.059	-1000.0
TCGA08_retinoblastoma	5.0	45.0	8.0	-0.073	0.024	1000.0	-1000.0	-0.015	-1000.0
EGFR-dependent Endothelin signaling events	5.0	109.0	21.0	-0.143	0.012	1000.0	-1000.0	-0.055	-1000.0
Syndecan-2-mediated signaling events	4.0	319.0	69.0	-0.143	0.029	1000.0	-1000.0	-0.023	-1000.0
p75(NTR)-mediated signaling	4.0	620.0	125.0	-0.13	0.031	1000.0	-1000.0	-0.074	-1000.0
Reelin signaling pathway	4.0	276.0	56.0	-0.088	0.024	1000.0	-1000.0	-0.058	-1000.0
Glypican 2 network	4.0	18.0	4.0	-0.014	-0.003	1000.0	-1000.0	-0.007	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	124.0	31.0	-0.136	0.012	1000.0	-1000.0	-0.053	-1000.0
LPA receptor mediated events	4.0	455.0	102.0	-0.149	0.012	1000.0	-1000.0	-0.074	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	334.0	68.0	-0.289	0.065	1000.0	-1000.0	-0.121	-1000.0
Plasma membrane estrogen receptor signaling	4.0	351.0	86.0	-0.056	0.048	1000.0	-1000.0	-0.069	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	395.0	88.0	-0.1	0.043	1000.0	-1000.0	-0.093	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	568.0	120.0	-0.21	0.129	1000.0	-1000.0	-0.062	-1000.0
LPA4-mediated signaling events	3.0	40.0	12.0	-0.028	0.011	1000.0	-1000.0	-0.02	-1000.0
Caspase cascade in apoptosis	3.0	245.0	74.0	-0.079	0.048	1000.0	-1000.0	-0.038	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	115.0	34.0	-0.047	0.012	1000.0	-1000.0	-0.038	-1000.0
Osteopontin-mediated events	3.0	139.0	38.0	-0.13	0.013	1000.0	-1000.0	-0.085	-1000.0
Cellular roles of Anthrax toxin	3.0	134.0	39.0	-0.042	0.012	1000.0	-1000.0	-0.021	-1000.0
Arf6 signaling events	3.0	191.0	62.0	-0.143	0.026	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by PTP1B	3.0	250.0	76.0	-0.144	0.031	1000.0	-1000.0	-0.066	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	220.0	61.0	-0.164	0.052	1000.0	-1000.0	-0.062	-1000.0
IL1-mediated signaling events	3.0	206.0	62.0	-0.072	0.022	1000.0	-1000.0	-0.078	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	258.0	82.0	-0.087	0.012	1000.0	-1000.0	-0.07	-1000.0
S1P1 pathway	3.0	110.0	36.0	-0.087	0.012	1000.0	-1000.0	-0.045	-1000.0
FAS signaling pathway (CD95)	3.0	150.0	47.0	-0.135	0.026	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	3.0	188.0	51.0	-0.164	0.079	1000.0	-1000.0	-0.06	-1000.0
EPHB forward signaling	3.0	289.0	85.0	-0.14	0.056	1000.0	-1000.0	-0.066	-1000.0
Effects of Botulinum toxin	3.0	91.0	26.0	-0.109	0.012	1000.0	-1000.0	-0.045	-1000.0
IL27-mediated signaling events	3.0	181.0	51.0	-0.286	0.02	1000.0	-1000.0	-0.062	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	3.0	90.0	27.0	-0.047	0.012	1000.0	-1000.0	-0.044	-1000.0
Visual signal transduction: Rods	3.0	156.0	52.0	-0.088	0.012	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PRL	3.0	118.0	34.0	-0.053	0.03	1000.0	-1000.0	-0.028	-1000.0
S1P4 pathway	3.0	75.0	25.0	-0.036	0.017	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	300.0	78.0	-0.077	0.06	1000.0	-1000.0	-0.069	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	56.0	17.0	-0.054	0.011	1000.0	-1000.0	-0.037	-1000.0
ErbB2/ErbB3 signaling events	2.0	135.0	65.0	-0.031	0.022	1000.0	-1000.0	-0.06	-1000.0
Coregulation of Androgen receptor activity	2.0	168.0	76.0	-0.127	0.041	1000.0	-1000.0	-0.035	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	78.0	28.0	-0.042	0.021	1000.0	-1000.0	-0.025	-1000.0
Visual signal transduction: Cones	2.0	88.0	38.0	-0.029	0.01	1000.0	-1000.0	-0.044	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	116.0	54.0	-0.098	0.022	1000.0	-1000.0	-0.076	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.024	0.012	1000.0	-1000.0	-0.033	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	12.0	5.0	-0.029	0.017	1000.0	-1000.0	-0.014	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	155.0	65.0	-0.063	0.029	1000.0	-1000.0	-0.056	-1000.0
PDGFR-alpha signaling pathway	2.0	111.0	44.0	-0.065	0.018	1000.0	-1000.0	-0.043	-1000.0
Nectin adhesion pathway	2.0	128.0	63.0	-0.036	0.022	1000.0	-1000.0	-0.06	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	82.0	37.0	-0.083	0.03	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	2.0	80.0	40.0	-0.063	0.021	1000.0	-1000.0	-0.018	-1000.0
S1P5 pathway	2.0	42.0	17.0	-0.036	0.02	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	2.0	102.0	35.0	-0.143	0.031	1000.0	-1000.0	-0.029	-1000.0
IL2 signaling events mediated by PI3K	2.0	127.0	58.0	-0.057	0.023	1000.0	-1000.0	-0.072	-1000.0
Integrins in angiogenesis	2.0	241.0	84.0	-0.134	0.023	1000.0	-1000.0	-0.069	-1000.0
Nongenotropic Androgen signaling	2.0	137.0	52.0	-0.036	0.018	1000.0	-1000.0	-0.04	-1000.0
IL2 signaling events mediated by STAT5	2.0	49.0	22.0	-0.038	0.018	1000.0	-1000.0	-0.05	-1000.0
Class I PI3K signaling events	2.0	207.0	73.0	-0.091	0.024	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	2.0	230.0	102.0	-0.15	0.032	1000.0	-1000.0	-0.097	-1000.0
S1P3 pathway	2.0	98.0	42.0	-0.055	0.019	1000.0	-1000.0	-0.042	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	72.0	33.0	-0.116	0.035	1000.0	-1000.0	-0.034	-1000.0
FOXM1 transcription factor network	2.0	106.0	51.0	-0.151	0.038	1000.0	-1000.0	-0.177	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	219.0	136.0	-0.062	0.055	1000.0	-1000.0	-0.052	-1000.0
Canonical NF-kappaB pathway	1.0	55.0	39.0	-0.03	0.043	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class II	1.0	132.0	75.0	-0.043	0.027	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	1.0	125.0	69.0	-0.107	0.025	1000.0	-1000.0	-0.072	-1000.0
BARD1 signaling events	1.0	75.0	57.0	-0.045	0.047	1000.0	-1000.0	-0.046	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	0.004	0.009	1000.0	-1000.0	-0.013	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	90.0	85.0	-0.047	0.04	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	1.0	63.0	55.0	-0.038	0.038	1000.0	-1000.0	-0.07	-1000.0
IFN-gamma pathway	1.0	96.0	68.0	-0.054	0.036	1000.0	-1000.0	-0.081	-1000.0
Ceramide signaling pathway	1.0	128.0	76.0	-0.143	0.046	1000.0	-1000.0	-0.046	-1000.0
TRAIL signaling pathway	1.0	83.0	48.0	-0.042	0.029	1000.0	-1000.0	-0.056	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	87.0	52.0	-0.057	0.03	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	1.0	52.0	43.0	-0.038	0.042	1000.0	-1000.0	-0.065	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	118.0	83.0	-0.169	0.044	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class I	1.0	119.0	104.0	-0.038	0.039	1000.0	-1000.0	-0.056	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	29.0	15.0	-0.028	0.019	1000.0	-1000.0	-0.019	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	53.0	45.0	-0.04	0.046	1000.0	-1000.0	-0.08	-1000.0
Regulation of p38-alpha and p38-beta	1.0	75.0	54.0	-0.091	0.03	1000.0	-1000.0	-0.051	-1000.0
TCGA08_rtk_signaling	1.0	50.0	26.0	-0.042	0.024	1000.0	-1000.0	-0.016	-1000.0
IL6-mediated signaling events	1.0	147.0	75.0	-0.105	0.037	1000.0	-1000.0	-0.069	-1000.0
IGF1 pathway	1.0	82.0	57.0	-0.029	0.025	1000.0	-1000.0	-0.072	-1000.0
Insulin Pathway	1.0	79.0	74.0	-0.1	0.027	1000.0	-1000.0	-0.074	-1000.0
VEGFR1 specific signals	1.0	71.0	56.0	-0.038	0.023	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.015	0.012	1000.0	-1000.0	-0.02	-1000.0
PDGFR-beta signaling pathway	1.0	145.0	97.0	-0.078	0.027	1000.0	-1000.0	-0.065	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.004	0.004	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	1.0	45.0	44.0	-0.017	0.022	1000.0	-1000.0	-0.056	-1000.0
Regulation of Androgen receptor activity	1.0	111.0	70.0	-0.202	0.041	1000.0	-1000.0	-0.058	-1000.0
Aurora B signaling	1.0	101.0	67.0	-0.098	0.028	1000.0	-1000.0	-0.049	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	7.0	23.0	0.004	0.034	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	0.0	11.0	22.0	-0.01	0.035	1000.0	-1000.0	-0.029	-1000.0
Aurora A signaling	0.0	47.0	60.0	-0.029	0.031	1000.0	-1000.0	-0.028	-1000.0
Arf6 downstream pathway	0.0	25.0	43.0	-0.02	0.02	1000.0	-1000.0	-0.035	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.001	0.018	1000.0	-1000.0	-0.024	-1000.0
PLK1 signaling events	0.0	68.0	85.0	-0.031	0.029	1000.0	-1000.0	-0.038	-1000.0
Insulin-mediated glucose transport	0.0	18.0	32.0	-0.01	0.029	1000.0	-1000.0	-0.046	-1000.0
mTOR signaling pathway	0.0	47.0	53.0	-0.012	0.023	1000.0	-1000.0	-0.049	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	44.0	68.0	-0.029	0.036	1000.0	-1000.0	-0.038	-1000.0
ceramide signaling pathway	0.0	33.0	49.0	-0.016	0.029	1000.0	-1000.0	-0.048	-1000.0
FoxO family signaling	0.0	29.0	64.0	-0.032	0.106	1000.0	-1000.0	-0.061	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	26.0	36.0	-0.033	0.034	1000.0	-1000.0	-0.056	-1000.0
Atypical NF-kappaB pathway	0.0	23.0	31.0	-0.03	0.028	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	90.0	125.0	-0.05	0.061	1000.0	-1000.0	-0.077	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	68.0	74.0	-0.143	0.053	1000.0	-1000.0	-0.074	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	68.0	76.0	-0.035	0.041	1000.0	-1000.0	-0.065	-1000.0
Arf6 trafficking events	0.0	38.0	71.0	-0.042	0.027	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling in keratinocytes	0.0	4.0	43.0	-0.031	0.036	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.024	1000.0	-1000.0	-0.018	-1000.0
Arf1 pathway	0.0	21.0	54.0	-0.018	0.028	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.031	1000.0	-1000.0	-0.026	-1000.0
Total	361	23861	7203	-12.7795890285	4.59860792371	131000	-131000	-7.08461740922	-131000