HotNet pathway analysis of mutation and copy number data
Skin Cutaneous Melanoma (Metastatic)
22 February 2013
|
analyses__2013_02_22
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2013):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C17M0655
Overview
Introduction
Summary
There were 5 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 5 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 5 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| CDH13(123),ADIPOR2(1),ADIPOQ(23) | 3 | 0.0265 | 1 |
| GSTM1(42),GSTM2(42),GSTM3(44) | 3 | 0.0265 | 1 |
| MTMR7(7),MTMR6(121),MTMR9(2) | 3 | 0.0265 | 1 |
| SLC12A1(98),RELL2(135),RELT(39) | 3 | 0.0265 | 1 |
| UPK3B(3),UPK1B(22),UPK3A(4) | 3 | 0.0265 | 1 |
Methods & Data
Copyright © 2013
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.