rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(2), CD3E(2), CD3G(2), CD4(4), CD58(1), CD8A(2), IL6(2), KITLG(3)	7120299	21	21	21	3	0	7	5	4	5	0	0.122	0.0217	1.000
2	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(1), CDK2(1), CUL1(2), E2F1(4), FBXW7(6), TFDP1(2)	7497996	16	16	15	1	5	3	2	3	3	0	0.0509	0.0425	1.000
3	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(5), CBS(2), CTH(3), MUT(3)	5387362	13	13	13	0	2	3	2	2	4	0	0.0276	0.0492	1.000
4	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD28(1), CD3E(2), CD3G(2), CD4(4)	3744423	11	11	11	2	1	4	2	1	3	0	0.312	0.0939	1.000
5	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(2)	1346070	4	4	4	0	0	3	0	1	0	0	0.208	0.120	1.000
6	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(2), IL12A(1), IL12B(1), IL18(1), IL2(1)	3530673	7	7	7	1	1	0	1	4	1	0	0.554	0.128	1.000
7	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(2), RAB11A(2), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(1)	4901601	10	10	10	1	0	4	3	0	3	0	0.192	0.134	1.000
8	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	11	APAF1(3), BAK1(2), BAX(2), BCL10(1), BCL2L11(4), BID(4), CASP9(1), CES1(2)	8480554	19	19	18	2	4	5	4	2	4	0	0.126	0.169	1.000
9	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), CREM(2), FHL5(2), FSHR(4), GNAS(5), XPO1(4)	10143105	20	20	19	2	4	4	4	5	3	0	0.105	0.183	1.000
10	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(5), ATM(18), BRCA1(12), CHEK2(3), JUN(3), MAPK8(2), MDM2(2), MRE11A(2), NFKB1(4), NFKBIA(1), RAD50(2), RAD51(2), RBBP8(4), RELA(1), TP73(1)	31833859	62	57	62	5	7	10	15	9	21	0	0.00463	0.219	1.000
11	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(4), ALDOB(2), ALDOC(1), TPI1(2)	4361469	9	9	9	0	0	4	3	1	1	0	0.0405	0.221	1.000
12	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	APAF1(3), ATM(18), BAX(2), CCND1(1), CCNE1(1), CDK2(1), CDK4(1), E2F1(4), MDM2(2), TIMP3(1)	17423711	34	33	33	4	6	6	5	6	11	0	0.0592	0.266	1.000
13	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7)	6140747	11	11	11	0	1	1	4	3	2	0	0.0596	0.285	1.000
14	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	3	CD28(1), CD4(4)	1746671	5	5	5	2	1	1	2	0	1	0	0.714	0.290	1.000
15	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	10	CCNE1(1), CDK2(1), CUL1(2), E2F1(4), NEDD8(1), SKP2(1), TFDP1(2)	7319484	12	12	11	1	4	1	4	1	2	0	0.146	0.308	1.000
16	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(3), CD3E(2), CD3G(2), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), JAK2(5), STAT4(6), TYK2(5)	16758186	43	39	43	7	5	8	9	8	13	0	0.101	0.317	1.000
17	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CCNE1(1), CDK2(1), CUL1(2), E2F1(4), SKP2(1), TFDP1(2)	7729534	12	12	11	1	4	1	3	1	3	0	0.163	0.346	1.000
18	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(3), GGT1(3)	6301403	13	13	12	2	2	4	4	1	2	0	0.198	0.357	1.000
19	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), FBL(2), GPT(3), LDHC(2), MAPK14(2), NCL(3)	10176986	18	18	18	2	6	5	4	2	1	0	0.0539	0.369	1.000
20	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(2)	1932077	3	3	3	1	1	0	0	0	2	0	0.731	0.400	1.000
21	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	9	B3GALT1(1), B3GALT2(1), B3GALT5(2), FUT2(2), FUT3(3), ST3GAL3(3), ST3GAL4(1)	7394854	13	13	12	2	4	4	3	0	2	0	0.0869	0.420	1.000
22	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	6	FUT2(2), FUT3(3), FUT5(2), FUT6(2), ST3GAL3(3)	4630960	12	12	11	3	4	1	4	0	3	0	0.237	0.423	1.000
23	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	825736	1	1	1	2	0	0	0	0	1	0	0.984	0.436	1.000
24	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP5(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), RFK(1), TYR(6)	11030458	24	24	23	4	3	4	11	3	3	0	0.237	0.442	1.000
25	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(2), GNAQ(1), GNB1(1), HTR2C(2), PLCB1(4), TUB(2)	7962830	12	12	12	1	4	1	5	1	1	0	0.151	0.443	1.000
26	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), LPL(1), NR3C1(2), PPARG(2), RXRA(1)	5923966	8	8	8	1	3	1	3	1	0	0	0.267	0.489	1.000
27	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), DAB1(4), LRP8(3), RELN(19), VLDLR(4)	15826286	31	29	30	4	5	7	12	3	4	0	0.0568	0.493	1.000
28	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3E(2), CD3G(2), CXCR3(5), ETV5(4), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), JAK2(5), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(6), TYK2(5)	21186549	51	47	51	9	8	9	10	9	15	0	0.0875	0.508	1.000
29	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), DNAJC3(4), EIF2S1(1), EIF2S2(2), NFKB1(4), NFKBIA(1), RELA(1)	10374476	14	14	14	0	4	6	3	0	1	0	0.0102	0.510	1.000
30	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(3), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1)	12098506	17	17	17	2	2	6	3	3	3	0	0.119	0.517	1.000
31	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(7), GLS(2)	8717627	15	15	15	2	2	4	5	3	1	0	0.154	0.530	1.000
32	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(4), HLCS(1)	3498453	5	5	5	0	1	1	3	0	0	0	0.205	0.536	1.000
33	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5)	11591288	23	22	23	4	3	2	7	5	6	0	0.304	0.548	1.000
34	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5)	11591288	23	22	23	4	3	2	7	5	6	0	0.304	0.548	1.000
35	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1)	6554782	7	7	7	1	3	2	2	0	0	0	0.298	0.573	1.000
36	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), JAK1(4), JAK2(5), STAT1(1)	9460686	12	12	12	1	1	1	3	2	5	0	0.323	0.573	1.000
37	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(4), CD8A(2), CSF1(3), IL11(1), IL2(1), IL6(2)	6806810	13	13	13	3	0	2	6	2	3	0	0.460	0.576	1.000
38	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(2), CDK7(2), MNAT1(2), XPO1(4)	9760766	18	18	17	3	3	3	9	1	2	0	0.318	0.578	1.000
39	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), NFYC(2), SP1(3), SP3(4)	5601216	10	10	10	2	0	2	1	4	3	0	0.529	0.601	1.000
40	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	9	CCL11(1), CCR3(1), CD4(4), IL5RA(2), IL6(2)	5170371	10	10	10	3	1	2	2	1	4	0	0.630	0.615	1.000
41	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(4), IARS(7), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	11533571	20	18	20	3	3	7	4	4	2	0	0.108	0.622	1.000
42	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	CDK5(1), FOSB(1), GRIA2(3)	3966413	5	5	5	1	0	2	2	1	0	0	0.469	0.622	1.000
43	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(1), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE3A(2)	11614960	16	16	16	1	0	5	6	1	4	0	0.137	0.628	1.000
44	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(3), HSD17B2(1), HSD17B4(6), HSD3B1(1), HSD3B2(3)	9142208	15	15	15	3	1	2	8	3	1	0	0.421	0.644	1.000
45	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(3), BAK1(2), BAX(2), BID(4), BIK(1), BIRC3(1), CASP6(2), CASP7(1), CASP9(1), DFFB(2)	13826468	19	18	18	1	3	7	1	0	8	0	0.0558	0.649	1.000
46	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(2)	1795419	2	2	2	0	0	0	1	0	1	0	0.553	0.649	1.000
47	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1)	8069600	13	13	13	2	4	1	2	4	2	0	0.334	0.673	1.000
48	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(2), UGDH(1), UXS1(2)	4553659	6	5	6	0	1	3	1	1	0	0	0.126	0.685	1.000
49	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	15	DNAJA3(1), IFNG(2), IKBKB(4), JAK2(5), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1), USH1C(5), WT1(2)	16655873	26	24	26	2	5	5	7	2	7	0	0.0181	0.696	1.000
50	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	7	CCL11(1), CCR3(1)	2447812	2	2	2	0	0	1	0	0	1	0	0.578	0.699	1.000
51	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PNPO(2)	5353689	6	6	6	1	0	0	3	1	2	0	0.625	0.700	1.000
52	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B1(1), HSD3B2(3)	9858751	20	20	20	4	6	2	10	2	0	0	0.165	0.700	1.000
53	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(2), HSD11B1(2), HSD3B1(1), HSD3B2(3)	9858751	20	20	20	4	6	2	10	2	0	0	0.165	0.700	1.000
54	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(2), COQ5(1), COQ6(2), NDUFA13(1)	4724867	6	6	6	0	0	1	4	1	0	0	0.257	0.707	1.000
55	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	11	CASP9(1), CHUK(1), GH1(1), GHR(2), NFKB1(4), NFKBIA(1), PPP2CA(2), RELA(1)	10506220	13	12	13	1	4	5	2	0	2	0	0.0766	0.719	1.000
56	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(2)	5760762	7	6	7	0	1	3	2	1	0	0	0.109	0.719	1.000
57	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	1750792	1	1	1	1	0	0	0	0	1	0	0.979	0.725	1.000
58	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1)	5912382	11	11	11	3	2	4	2	2	1	0	0.372	0.737	1.000
59	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(1), NFKB1(4), NFKBIA(1), PLCB1(4), RELA(1)	9254455	11	11	11	1	3	3	3	0	2	0	0.143	0.738	1.000
60	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP5(2), ACP6(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(2), RFK(1), TYR(6)	17022927	30	29	29	4	4	6	13	4	3	0	0.0953	0.739	1.000
61	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(4), F2R(3), F5(14), F7(1), FGA(5), FGB(1), FGG(4), PROC(1), PROS1(1), SERPINC1(4), TFPI(2)	18200086	40	38	40	6	4	7	16	7	6	0	0.0884	0.746	1.000
62	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	21	ATF1(2), CASP2(3), CHUK(1), IKBKB(4), JUN(3), LTA(1), MAP2K3(2), MAP2K6(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFRSF1A(1)	22044619	33	32	33	3	5	11	8	2	7	0	0.00323	0.747	1.000
63	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(3), CD3E(2), CD3G(2), HLA-A(4), ICAM1(1), ITGAL(1), ITGB2(4), PRF1(2)	9271320	19	18	18	4	3	6	2	4	4	0	0.189	0.761	1.000
64	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), ENO1(1), GPI(2), HK1(1), PFKL(1), PGK1(3), PKLR(3), TPI1(2)	9939461	15	15	15	3	2	3	2	4	4	0	0.161	0.767	1.000
65	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(2)	5976859	9	9	8	2	4	1	3	0	1	0	0.367	0.768	1.000
66	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSS(2), NFKB1(4), NOX1(1), RELA(1), SOD1(1), XDH(4)	11019907	13	13	13	1	3	2	3	4	1	0	0.0865	0.769	1.000
67	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNAS(5), GNB1(1), PRKACA(2), PRKAR1A(4)	6662977	15	15	15	4	2	2	1	5	5	0	0.648	0.770	1.000
68	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1765846	1	1	1	1	1	0	0	0	0	0	0.933	0.771	1.000
69	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(1), KHK(1), LCT(11), MPI(2), PGM1(1), PYGL(2), PYGM(5), TPI1(2), TREH(1)	15155437	26	26	26	4	5	2	6	6	7	0	0.0852	0.807	1.000
70	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1), SUCLA2(1)	2360615	2	2	2	1	0	0	0	2	0	0	0.844	0.807	1.000
71	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	14	CHUK(1), CREBBP(7), EP300(7), HDAC3(1), IKBKB(4), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(3)	24286115	33	32	32	2	5	10	7	4	7	0	0.00160	0.814	1.000
72	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	TAT(2)	2978435	2	2	2	1	1	0	0	0	1	0	0.900	0.823	1.000
73	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(3), MST1(3), MST1R(2)	6334411	8	7	8	0	2	2	3	0	1	0	0.0888	0.824	1.000
74	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	17	CCND1(1), CCNE1(1), CDK2(1), CDK4(1), CDK6(1), E2F1(4), MAPK1(1), MAPK3(1), NFKB1(4), NFKBIA(1), PAK1(2), RAF1(1), RELA(1), TFDP1(2)	14731479	22	22	21	3	7	5	4	3	3	0	0.0661	0.825	1.000
75	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(5), MAPK1(1), MAPK3(1), STAT3(3), TYK2(5)	12774329	24	22	24	4	5	4	5	3	7	0	0.170	0.827	1.000
76	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(4), GBA(1), GBA3(2), LPO(5), MPO(3), TPO(5)	9401078	20	20	20	4	8	2	3	4	3	0	0.180	0.830	1.000
77	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	18	APAF1(3), ATM(18), BAX(2), BID(4), CASP6(2), CASP7(1), CASP9(1), EIF2S1(1), PTK2(5), STAT1(1), TLN1(12)	29168666	50	48	49	6	6	14	9	5	16	0	0.0218	0.834	1.000
78	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), CHAT(1), PCYT1A(2), PDHA1(2), PDHA2(2), SLC18A3(2)	7149740	10	10	10	2	2	4	3	1	0	0	0.246	0.844	1.000
79	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK14(2), MAPK8(2), NFKB1(4), RELA(1), TNFSF13B(1), TRAF3(2), TRAF5(1), TRAF6(3)	16211554	17	17	17	1	2	6	3	2	3	1	0.0193	0.856	1.000
80	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), JUN(3), KEAP1(2), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(2)	9486454	13	13	13	3	3	2	2	0	5	1	0.331	0.856	1.000
81	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMB8(1)	9269165	11	11	11	2	1	2	3	3	2	0	0.361	0.879	1.000
82	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(2), ALDH1A2(1), BCMO1(6), RDH5(1)	4364317	10	11	11	6	1	1	4	1	3	0	0.921	0.885	1.000
83	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), COPA(3), GBF1(7), GPLD1(3), KDELR2(1), KDELR3(1)	18446513	23	23	23	2	2	5	10	3	3	0	0.0258	0.892	1.000
84	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(3), EPOR(4), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(4), NFKBIA(1), RELA(1)	13901350	20	20	20	3	2	5	6	2	5	0	0.189	0.895	1.000
85	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ARG1(2), GLS(2), PRODH(1)	6098317	5	5	5	1	2	0	1	0	2	0	0.575	0.900	1.000
86	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(1), HGD(1)	2554068	3	3	3	2	1	0	0	2	0	0	0.894	0.901	1.000
87	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(1), ADORA2A(2), ADORA3(2), P2RY1(3), P2RY2(1), P2RY6(1)	6077131	10	10	10	3	3	2	3	2	0	0	0.370	0.902	1.000
88	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	4	PLCB1(4), PLCG1(6), VAV1(4)	9346920	14	14	14	3	4	3	3	1	3	0	0.305	0.902	1.000
89	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	14	ACTA1(2), APAF1(3), CASP9(1), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(1)	12000081	14	14	14	2	2	4	5	1	2	0	0.222	0.904	1.000
90	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	13	CASP1(1), CASP7(1), GAPDH(1), INSR(4), ITCH(1), MAGI1(10), MAGI2(9), RERE(7), WWP1(2), WWP2(7)	22583041	43	43	38	7	9	9	6	7	11	1	0.0923	0.904	1.000
91	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP54(1), SRP68(3), SRP72(1), SRPR(9)	8615968	14	12	14	3	1	4	3	4	2	0	0.404	0.908	1.000
92	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	14	ADRB2(1), ANXA1(1), GNAS(5), GNB1(1), NFKB1(4), NOS3(3), NPPA(1), NR3C1(2), RELA(1)	14029803	19	19	19	3	4	5	4	3	3	0	0.163	0.908	1.000
93	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(6), RANGAP1(2)	9579891	9	9	9	0	0	3	3	1	2	0	0.174	0.908	1.000
94	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	11	APAF1(3), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP9(1), JUN(3), PRF1(2)	13174223	14	14	14	2	4	2	2	2	4	0	0.223	0.920	1.000
95	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), TAT(2), TYR(6)	5338376	9	9	9	3	1	4	3	0	1	0	0.627	0.922	1.000
96	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(3), AFMID(1), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4)	15330838	23	21	23	4	4	7	9	2	1	0	0.0972	0.922	1.000
97	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	17	ATF2(2), CHUK(1), IFNG(2), IKBKB(4), IL2(1), JUN(3), MAP3K5(2), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF9(2)	19114688	28	26	28	4	6	7	8	1	6	0	0.0872	0.923	1.000
98	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(3), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4)	14602403	22	20	22	4	3	7	9	2	1	0	0.125	0.925	1.000
99	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), PRDX1(1), PRDX5(1), SHMT2(1), TPO(5)	13170415	22	22	22	4	9	4	2	3	4	0	0.100	0.926	1.000
100	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(4), MAX(3), MYC(1), SP1(3), SP3(4), WT1(2)	6765870	17	16	17	5	3	2	2	5	5	0	0.616	0.927	1.000
101	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(7), CD44(2), CSF1(3), FCGR3A(1), IL6R(1), SELL(5), SPN(2), TGFB1(2), TNFRSF1A(1), TNFRSF8(2)	14639139	26	26	25	5	1	4	13	3	5	0	0.271	0.927	1.000
102	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(2)	9990812	13	12	13	3	1	3	2	4	3	0	0.306	0.933	1.000
103	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(3), CAPN1(4), CDK5(1), CSNK1A1(1), MAPT(3), PPP2CA(2)	10344177	14	13	14	2	2	2	6	2	2	0	0.298	0.935	1.000
104	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(4), JAK2(5), JAK3(5), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5), TYK2(5)	20295706	38	36	38	6	10	3	11	3	11	0	0.0627	0.937	1.000
105	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	11373903	12	12	12	2	3	3	1	4	1	0	0.160	0.937	1.000
106	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(4), RELA(1), TNFRSF11A(2), TRAF6(3)	11993574	17	17	17	4	4	6	2	3	2	0	0.197	0.940	1.000
107	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(1), HSD11B1(2), HSD3B1(1), HSD3B2(3)	7677187	14	14	14	4	3	0	8	3	0	0	0.457	0.941	1.000
108	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(1), ENO3(2), FARS2(1), PAH(2), TAT(2)	9415372	8	8	8	1	1	2	3	1	1	0	0.284	0.943	1.000
109	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3E(2), CD3G(2), CD8A(2), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	11800070	19	18	19	4	1	6	4	5	3	0	0.220	0.946	1.000
110	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), DFFB(2), HMGB1(1), HMGB2(3), TOP2A(2)	12027444	9	9	9	1	0	4	2	2	1	0	0.325	0.949	1.000
111	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(1), AASDHPPT(3), AASS(3)	8023299	7	7	7	2	1	1	3	0	2	0	0.807	0.950	1.000
112	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(3), BMPR1B(3), BMPR2(3)	6905501	9	8	8	3	0	2	1	1	5	0	0.579	0.951	1.000
113	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), MYT1(5), WEE1(2)	15792073	31	30	31	6	3	6	8	6	8	0	0.260	0.952	1.000
114	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME2(2), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TPI1(2)	19895424	28	28	28	4	8	8	7	4	1	0	0.0189	0.952	1.000
115	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(3), AASS(3)	5472377	6	6	6	2	1	1	3	0	1	0	0.806	0.955	1.000
116	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(1)	7225673	6	6	6	1	1	3	2	0	0	0	0.392	0.955	1.000
117	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(1), APOBEC2(2), APOBEC3A(2), APOBEC3B(1), APOBEC3C(1), APOBEC3G(1), APOBEC4(1)	8405128	11	11	11	3	5	3	0	1	2	0	0.458	0.956	1.000
118	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(1), CCNA2(3), CCND1(1), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), E2F1(4), E2F4(4), PRB1(2)	8988867	19	19	17	5	5	2	2	3	7	0	0.576	0.958	1.000
119	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	7	CTH(3), LDHC(2)	7384720	5	5	5	0	0	1	1	0	3	0	0.272	0.960	1.000
120	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), IFNG(2), JAK1(4), JAK2(5), PTPRU(5), REG1A(1), STAT1(1)	12909586	19	19	19	4	3	3	3	3	7	0	0.507	0.960	1.000
121	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(6), CS(1), PC(5), PDHA1(2), SLC25A1(1), SLC25A11(1)	10127063	16	14	16	3	2	5	4	3	2	0	0.177	0.961	1.000
122	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(2)	8668966	9	9	9	2	1	2	5	1	0	0	0.596	0.963	1.000
123	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(1)	15710499	30	28	30	6	6	8	5	9	2	0	0.0915	0.964	1.000
124	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), NAGLU(1), SPAM1(2)	22538440	44	41	44	9	7	9	11	11	6	0	0.113	0.964	1.000
125	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), CDK2(1), CDK4(1), MYT1(5), WEE1(2)	17226937	33	32	33	6	3	6	8	7	9	0	0.230	0.966	1.000
126	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2)	15343038	33	28	33	6	5	10	11	3	4	0	0.0716	0.970	1.000
127	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	RDH11(2), RDH12(1), RDH14(2)	5260243	5	5	5	2	0	1	1	2	1	0	0.683	0.972	1.000
128	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(4), STAT1(1), STAT2(2), TYK2(5)	12075678	16	16	16	4	3	4	3	2	4	0	0.420	0.973	1.000
129	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(3), GAD1(2), TH(1)	6117601	6	6	6	2	1	1	2	1	1	0	0.732	0.973	1.000
130	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(4), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), PANK1(1), PANK2(1), PANK4(3), UPB1(3)	15106402	25	24	25	5	2	5	6	6	6	0	0.315	0.974	1.000
131	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(7), DFFB(2), GZMA(2), HMGB2(3), PRF1(2), SET(1)	11943688	18	18	18	4	3	3	4	4	4	0	0.393	0.974	1.000
132	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	ARF1(1), CCND1(1), CDK2(1), CDK4(1), E2F1(4), MDM2(2), PRB1(2)	7284450	12	12	12	4	5	1	2	2	2	0	0.570	0.975	1.000
133	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(4), GBA3(2), LPO(5), MPO(3), PRDX1(1), PRDX5(1), TPO(5), TYR(6)	10820109	27	26	27	6	8	6	5	4	4	0	0.169	0.975	1.000
134	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	B3GNT1(1), FUT2(2), GCNT2(1), ST8SIA1(1)	6057719	5	5	4	5	0	0	1	1	3	0	0.966	0.975	1.000
135	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1)	6316184	10	9	9	4	4	1	4	0	1	0	0.615	0.976	1.000
136	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(4), F2(4), F2R(3), FGA(5), FGB(1), FGG(4), PLAT(3), PLAU(2), PLG(4), SERPINE1(3)	15433587	34	33	34	8	1	5	19	5	4	0	0.450	0.977	1.000
137	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), CHAT(1), DBH(3), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(2), SLC18A3(2), TH(1)	14866107	18	18	18	3	3	5	6	2	2	0	0.171	0.978	1.000
138	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), FARSA(1), FARSB(3), PAH(2), TAT(2), YARS2(1)	9847716	10	10	10	2	2	3	4	0	1	0	0.320	0.978	1.000
139	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2)	12672542	12	12	12	2	3	3	1	4	1	0	0.153	0.978	1.000
140	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	7	CD28(1), CD4(4), IL2(1)	3566959	6	6	6	3	1	1	2	1	1	0	0.828	0.979	1.000
141	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	7	CD44(2), ICAM1(1), ITGAL(1), ITGAM(3), ITGB2(4), SELE(1), SELL(5)	12183341	17	16	17	4	0	2	7	4	4	0	0.460	0.980	1.000
142	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	9	ALDOA(4), ESR1(3), GREB1(3), MTA3(2)	10821293	12	12	12	3	1	5	3	1	2	0	0.301	0.982	1.000
143	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(7), EP300(7), ESR1(3), MAPK1(1), MAPK3(1), PELP1(2)	16649156	21	21	20	4	4	5	4	2	6	0	0.222	0.982	1.000
144	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(6), PTK2B(3)	7527227	10	10	10	3	1	3	3	1	2	0	0.444	0.984	1.000
145	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	14	APAF1(3), BIRC3(1), CASP7(1), CASP9(1), DFFB(2), PRF1(2), SCAP(3), SREBF1(1), SREBF2(4)	17980371	18	17	18	2	2	8	4	0	4	0	0.0620	0.985	1.000
146	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(3), IL6(2), LDLR(1), LPL(1)	5878014	9	9	9	4	0	3	3	1	2	0	0.781	0.986	1.000
147	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(3), SHMT2(1)	4620006	6	6	5	3	1	4	0	1	0	0	0.685	0.986	1.000
148	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CARS2(2), CDO1(1), CTH(3), LDHC(2), SULT1B1(1), SULT1C2(1)	13787147	10	10	10	1	0	3	2	0	5	0	0.295	0.986	1.000
149	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), SHMT2(1), TPO(5)	12895954	20	20	20	4	9	3	2	3	3	0	0.142	0.987	1.000
150	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), PGD(2)	19879962	32	30	31	5	7	6	6	9	4	0	0.0338	0.987	1.000
151	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(7), AGT(2), BDKRB2(1), KNG1(4), NOS3(3), REN(1)	10454834	18	18	18	5	2	4	6	3	3	0	0.414	0.987	1.000
152	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRB(1), IL10RA(2), IL10RB(4), IL1A(1), IL6(2), JAK1(4), STAT1(1), STAT3(3), STAT5A(4)	13440262	22	20	22	5	7	3	4	2	6	0	0.181	0.987	1.000
153	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	3766916	5	5	5	3	1	1	2	0	1	0	0.915	0.987	1.000
154	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PPT2(1)	9391173	14	13	14	4	0	5	6	2	1	0	0.563	0.987	1.000
155	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	15120364	13	13	13	2	3	5	5	0	0	0	0.155	0.988	1.000
156	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(7), DAXX(2), PAX3(2), PML(1), RARA(2), SIRT1(2), SP100(5), TNFRSF1A(1)	17276533	22	22	22	4	3	4	6	4	5	0	0.309	0.988	1.000
157	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), CAD(10), CRAT(6), DARS(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), PC(5)	28744332	52	47	52	7	7	15	18	6	6	0	0.00300	0.989	1.000
158	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	8	BAG4(1), BIRC3(1), RIPK1(3), TNFRSF1A(1)	6951395	6	6	6	2	0	2	1	0	3	0	0.685	0.989	1.000
159	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	12	FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MANBA(2), NEU2(1)	17013217	21	21	21	4	2	5	5	6	3	0	0.220	0.989	1.000
160	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), ADRB2(1), CFTR(9), GNAS(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2)	13926292	27	26	27	6	4	2	6	6	9	0	0.507	0.990	1.000
161	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP5(2), ACP6(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1)	19702850	35	28	33	7	8	5	13	5	4	0	0.151	0.990	1.000
162	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(2)	15146753	15	15	15	3	0	3	5	3	4	0	0.483	0.990	1.000
163	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), UGDH(1)	9285542	6	6	6	1	0	3	3	0	0	0	0.346	0.991	1.000
164	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(1), GBA3(2), GGT1(3), SHMT2(1)	6258949	7	7	6	3	1	4	1	1	0	0	0.648	0.991	1.000
165	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), JUN(3), MAPK14(2), THBS1(4)	8056805	10	9	10	7	1	1	1	3	4	0	0.992	0.991	1.000
166	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMD1(5), PSMD11(2), PSMD12(1), PSMD2(2), PSMD6(2)	18410354	22	22	22	4	2	4	8	4	4	0	0.317	0.992	1.000
167	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	19	CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), E2F1(4), RBL1(3), TFDP1(2)	14924329	24	24	23	5	4	2	8	5	5	0	0.407	0.992	1.000
168	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), OXCT1(1)	3880956	3	3	3	2	0	1	1	1	0	0	0.904	0.993	1.000
169	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(4), BCAT2(3), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), ILVBL(1), PANK1(1), PANK2(1), PANK4(3), UPB1(3), VNN1(3)	18922659	32	31	32	7	4	6	7	8	7	0	0.256	0.994	1.000
170	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(2), IFNG(2), IL2(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(3)	12166859	21	20	21	5	3	8	5	3	2	0	0.249	0.995	1.000
171	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(1), PLCD1(1), TGM2(2)	5470914	4	4	4	3	1	0	1	0	2	0	0.929	0.995	1.000
172	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1)	17856135	30	30	30	7	5	7	6	8	4	0	0.225	0.995	1.000
173	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	9	CAT(1), GH1(1), GHR(2), IGF1(1), IGF1R(2), SHC1(1), SOD1(1)	9291206	9	9	9	3	2	2	5	0	0	0	0.561	0.995	1.000
174	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	20	APAF1(3), ARHGDIB(1), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), DFFB(2), LMNA(1), LMNB1(1), PRF1(2)	20006706	20	20	20	3	3	6	4	2	5	0	0.150	0.996	1.000
175	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	17	BAX(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(4), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(1), TNFRSF1A(1)	16981734	19	19	18	3	3	6	3	1	6	0	0.118	0.996	1.000
176	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(3), HLA-A(4), IL18(1), ITGB1(3), KLRC1(3), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PTK2B(3), SYK(2), VAV1(4)	16854905	29	29	28	6	5	6	10	5	3	0	0.224	0.996	1.000
177	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	22	ARSA(1), ARSB(4), ARSE(2), ASAH1(1), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD1(1), SPTLC1(2), SPTLC2(2)	25220776	36	32	36	5	8	5	10	9	4	0	0.0422	0.996	1.000
178	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(2), GFPT1(2), GNE(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), PGM3(1), RENBP(1), UAP1(1)	19085118	22	22	22	4	3	5	5	6	3	0	0.179	0.997	1.000
179	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), GRB2(1), PTPRA(2)	10294125	11	11	11	3	3	1	5	1	1	0	0.516	0.997	1.000
180	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	10	CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), SELE(1), SELL(5), SELP(8)	18469955	30	28	30	7	2	4	11	9	4	0	0.374	0.997	1.000
181	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), IDI1(2), SQLE(1)	5008038	5	5	5	4	1	1	2	0	1	0	0.971	0.997	1.000
182	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3)	7012955	9	9	9	3	2	5	0	1	1	0	0.609	0.997	1.000
183	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(18), ATR(6), BRCA1(12), BRCA2(14), CHEK2(3), FANCA(7), FANCC(1), FANCD2(5), FANCE(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD1(1), RAD17(2), RAD50(2), RAD51(2), RAD9A(2)	49161926	82	76	82	10	7	11	22	15	27	0	0.0224	0.997	1.000
184	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), ADRB2(1), GNAS(5), PLCE1(12), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAP2B(2)	15840474	30	30	30	8	6	3	7	6	8	0	0.508	0.998	1.000
185	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(18), ATR(6), CDC25C(2), CHEK2(3)	17358703	29	28	29	5	3	6	4	8	8	0	0.241	0.998	1.000
186	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG3(4), PSEN1(1)	10328413	11	11	11	3	1	4	4	1	1	0	0.515	0.998	1.000
187	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(3), SNCAIP(3), UBE2F(1), UBE2L6(1)	7099745	10	10	10	4	1	2	5	2	0	0	0.809	0.998	1.000
188	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(1), JUN(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(4), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1)	16716966	19	18	19	4	5	6	2	1	5	0	0.145	0.998	1.000
189	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(4), AARS2(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), ASS1(1), CAD(10), CRAT(6), DARS(1), DARS2(2), DLD(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), NARS2(2), PC(5), PDHA1(2), PDHA2(2), PDHB(1)	41803868	67	60	67	9	12	18	23	8	6	0	0.00123	0.998	1.000
190	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLUD2(2)	5001258	4	4	4	2	2	0	0	1	1	0	0.791	0.998	1.000
191	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(7), C5(4), C6(5), C7(6), C9(1)	14680450	23	23	23	6	3	5	8	3	4	0	0.423	0.998	1.000
192	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	16	CD28(1), CD86(2), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), IL2(1), IL4R(4)	13559574	20	19	20	6	3	2	8	5	2	0	0.573	0.998	1.000
193	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(5), GNB1(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	10397489	14	14	14	5	1	2	3	3	5	0	0.842	0.998	1.000
194	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(5), NT5M(1)	16477866	26	26	26	7	2	1	14	5	4	0	0.591	0.998	1.000
195	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	7	CAMK1(2), CAMK1G(1), HDAC9(5), MEF2B(1), MEF2C(3), MEF2D(2)	8021995	14	14	14	6	2	3	4	2	3	0	0.689	0.998	1.000
196	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	17	BCR(3), CRKL(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), MYC(1), RAF1(1), SOS1(4), STAT1(1), STAT5A(4), STAT5B(5)	21245005	33	33	33	7	7	4	7	4	11	0	0.167	0.998	1.000
197	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(4), BCAT2(3), IARS(7), IARS2(2), ILVBL(1), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1)	18128619	26	24	26	5	5	7	6	5	3	0	0.135	0.999	1.000
198	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(5), ERBB3(11), NRG1(2)	11626119	21	21	21	6	3	2	10	5	1	0	0.617	0.999	1.000
199	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(1), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	10823740	17	17	16	6	3	4	3	2	5	0	0.480	0.999	1.000
200	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(7), EP300(7), LPL(1), NCOA1(2), NCOA2(3), PPARG(2), RXRA(1)	20754650	23	21	22	4	5	4	6	3	5	0	0.158	0.999	1.000
201	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	11	BCAR1(2), GRB2(1), ILK(2), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(2), PTK2(5), SHC1(1), SOS1(4)	14503084	22	22	22	5	3	6	5	4	4	0	0.304	0.999	1.000
202	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(5), E2F1(4), MDM2(2), MYC(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4)	14341828	26	25	26	7	5	4	4	6	7	0	0.404	0.999	1.000
203	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(2), DHRS2(4), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2)	16248556	30	27	30	8	6	10	8	2	4	0	0.218	0.999	1.000
204	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(2), IMPDH1(2), POLB(1), POLD1(1), POLG(4), PRPS2(1), RRM1(2), SRM(1)	13694900	14	13	14	3	2	2	7	0	3	0	0.475	0.999	1.000
205	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	10	GRB2(1), IL2RG(1), IL4R(4), IRS1(2), JAK1(4), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(2)	14503793	22	21	22	5	3	4	7	4	4	0	0.318	0.999	1.000
206	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), DPAGT1(2), DPM1(2), MAN1A1(1), MAN1B1(4), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2)	20779748	28	27	28	5	6	4	8	3	7	0	0.165	0.999	1.000
207	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), GAMT(1), GATM(4), OTC(1)	19236150	29	29	29	6	4	6	11	7	1	0	0.198	0.999	1.000
208	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(8), GABBR1(1), GPRC5A(1), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM7(3), GRM8(3)	21479340	35	32	35	7	9	7	11	3	5	0	0.0381	0.999	1.000
209	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1)	11488825	19	19	18	7	3	4	5	2	5	0	0.559	0.999	1.000
210	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(3), CMAS(2), CTBS(1), CYB5R1(2), GFPT1(2), GFPT2(3), GNE(3), GNPDA2(1), GNPNAT1(2), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), MTMR1(1), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1)	32291826	38	37	38	5	5	10	9	9	5	0	0.0200	0.999	1.000
211	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	AOC2(1), AOC3(3), CES1(2), ESD(1)	6413677	7	7	7	4	2	1	3	0	1	0	0.822	1.000	1.000
212	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(4), CSF1(3), IFNA1(1), IFNB1(1), IFNG(2), IL11(1), IL12A(1), IL12B(1), IL15(2), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB1(2), TGFB3(1)	13747820	24	23	24	7	3	6	8	3	4	0	0.452	1.000	1.000
213	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(1), CD3E(2), CD3G(2), CD4(4), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	12582643	21	20	21	6	1	7	5	4	4	0	0.373	1.000	1.000
214	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1)	6329092	7	7	7	3	4	0	0	2	1	0	0.684	1.000	1.000
215	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1)	6329092	7	7	7	3	4	0	0	2	1	0	0.684	1.000	1.000
216	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUL(1), HAL(2)	21397292	29	29	29	6	2	4	9	7	7	0	0.205	1.000	1.000
217	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(3), IDH1(2), MDH2(1), SDHB(1), SUCLA2(1)	10205370	10	10	10	4	2	1	3	4	0	0	0.717	1.000	1.000
218	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GPX7(1), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), TXNDC12(1)	22234778	34	32	33	7	7	7	8	8	4	0	0.0735	1.000	1.000
219	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TKTL1(2), TKTL2(1), TPI1(2)	22314990	29	29	29	6	8	8	7	5	1	0	0.0698	1.000	1.000
220	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	36	APAF1(3), BAK1(2), BAX(2), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP9(1), FAS(1), FASLG(2), JUN(3), MAPK10(2), MCL1(1), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), PARP1(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF1(1)	34290235	47	46	46	8	11	13	9	2	12	0	0.0294	1.000	1.000
221	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(6), AP2A1(6), AP2M1(4), DNM1(6), EPN1(1), EPS15(4), PICALM(1), PPP3CA(4), PPP3CB(3), SYNJ1(2), SYNJ2(1)	25202726	38	35	38	7	5	4	15	6	8	0	0.176	1.000	1.000
222	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(2), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(6), PTK2B(3)	15262681	19	19	19	7	3	3	5	1	7	0	0.665	1.000	1.000
223	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	11	CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(4), RELA(1), SP1(3)	11636167	18	18	18	5	4	6	4	3	1	0	0.353	1.000	1.000
224	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(3), ASPH(4), CREB1(1), EDN1(2), EP300(7), HIF1A(1), JUN(3), NOS3(3), P4HB(1)	18745634	25	24	24	6	3	5	5	4	8	0	0.470	1.000	1.000
225	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(2), FURIN(1), NOTCH1(5), PSEN1(1)	8242048	9	8	9	4	1	3	1	2	2	0	0.762	1.000	1.000
226	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	12	CARM1(2), CREB1(1), CREBBP(7), EP300(7), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RARA(2), RXRA(1)	19541565	27	26	26	7	5	3	6	4	9	0	0.444	1.000	1.000
227	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(2), IL6R(1), JAK1(4), JAK2(5), JAK3(5), PTPRU(5), REG1A(1), STAT3(3)	16836850	27	26	27	8	4	5	5	4	9	0	0.546	1.000	1.000
228	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(6), PRKACG(1), PRKAR2A(1), PRKAR2B(1)	11307734	9	9	9	3	1	5	2	1	0	0	0.544	1.000	1.000
229	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	21	AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT12(1)	23745898	33	33	33	8	4	1	16	7	5	0	0.410	1.000	1.000
230	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), IL15(2), IL18(1), IL1A(1), IL2(1), IL6(2), LTA(1)	10867765	14	13	14	5	3	2	2	4	3	0	0.654	1.000	1.000
231	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	8553637	13	12	13	5	2	4	4	1	2	0	0.722	1.000	1.000
232	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK1(4), JAK2(5), JAK3(5), PIAS1(2), PTPRU(5), REG1A(1), SOAT1(1)	15345669	24	23	24	7	3	5	6	3	7	0	0.579	1.000	1.000
233	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), PER1(3)	9212257	10	10	10	4	1	2	2	3	2	0	0.814	1.000	1.000
234	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(1), HMGCS1(3), HMGCS2(1), OXCT1(1), OXCT2(1)	8248642	9	9	9	5	0	2	3	3	1	0	0.914	1.000	1.000
235	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	9	CD3E(2), CD3G(2), CD4(4), LCK(1), PTPRC(3), ZAP70(2)	9146933	14	14	14	9	2	6	3	1	2	0	0.911	1.000	1.000
236	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	14254026	21	21	21	8	6	0	6	3	6	0	0.782	1.000	1.000
237	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), NDUFA1(1), SDHB(1), UQCRC1(3)	7422810	7	7	7	6	1	0	2	3	1	0	0.985	1.000	1.000
238	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(2), CRK(1), GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(4), PIK3C2G(3), PLCG1(6), PTK2(5), PTK2B(3), RAF1(1), RELA(1)	26894767	32	31	32	6	4	9	9	6	4	0	0.0865	1.000	1.000
239	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(9), FASN(8), MCAT(1), OLAH(1), OXSM(1)	16625611	24	23	24	6	6	1	10	2	5	0	0.435	1.000	1.000
240	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	13	AKT2(3), AKT3(4), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(4), SHC1(1), SOS1(4)	13739791	26	25	26	9	6	4	8	2	6	0	0.530	1.000	1.000
241	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), ELK1(2), GRB2(1), JUN(3), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(4)	16610654	26	24	26	8	6	5	4	4	7	0	0.389	1.000	1.000
242	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), PC(5), PCK1(2), SDHB(1), SUCLA2(1)	23285861	26	24	26	5	4	6	9	6	1	0	0.128	1.000	1.000
243	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELE(1), SELL(5)	13824709	19	19	19	6	0	1	8	7	3	0	0.742	1.000	1.000
244	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CAMKK1(3), CAMKK2(2), CREB1(1)	12835234	19	17	19	5	4	3	3	5	4	0	0.437	1.000	1.000
245	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1)	19483461	28	27	28	7	4	7	9	3	5	0	0.268	1.000	1.000
246	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2)	14045927	16	15	16	9	3	1	3	3	6	0	0.944	1.000	1.000
247	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1(3), DDX20(2), E2F1(4), E2F4(4), ETS1(3), ETS2(5), ETV3(3), HDAC2(3), HDAC5(3), JUN(3), RBL1(3), RBL2(1), SIN3A(4), SIN3B(5)	25109017	46	44	44	10	7	12	7	8	12	0	0.206	1.000	1.000
248	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	17	EIF4A2(6), EIF4B(1), EIF4G1(2), EIF4G2(2), EIF4G3(4), PDK2(2), PPP2CA(2), RPS6(2), RPS6KB1(2), TSC1(4), TSC2(2)	24603295	29	28	29	5	4	9	8	3	5	0	0.141	1.000	1.000
249	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(1), JAK1(4), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(5)	13807981	20	20	20	6	5	4	3	3	5	0	0.545	1.000	1.000
250	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(2), ELOVL5(4), ELOVL6(3), FADS1(1), FADS2(4), FASN(8), SCD(1)	14880522	25	25	25	9	2	4	11	2	6	0	0.754	1.000	1.000
251	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(3), IGF1(1), IL11(1), IL1A(1), IL6(2), KITLG(3), TGFB1(2), TGFB3(1)	9518312	14	12	14	6	2	4	4	2	2	0	0.710	1.000	1.000
252	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(4), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(7), LARS(2), LARS2(2), MARS(2), NARS(1), QARS(3), RARS(3), SARS(3), TARS(5), WARS2(1)	36431020	41	40	41	6	7	10	11	9	4	0	0.0324	1.000	1.000
253	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUD2(2), GLUL(1), HAL(2)	23843910	31	31	31	7	3	4	9	8	7	0	0.231	1.000	1.000
254	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), GCK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), PFKFB1(1), PFKFB3(1), PFKM(4), PFKP(2), SORD(2), TPI1(2)	26903027	33	33	33	7	6	8	6	7	6	0	0.0600	1.000	1.000
255	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	16	ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(1), DPEP1(3), GGT1(3), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1)	16474417	23	23	21	6	6	4	7	3	3	0	0.255	1.000	1.000
256	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS2(4), HMBS(1), PPOX(2)	8797329	7	7	7	3	2	2	3	0	0	0	0.816	1.000	1.000
257	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	9	GRB2(1), KLK2(2), NTRK1(4), PLCG1(6), SHC1(1), SOS1(4)	12115650	18	17	18	6	3	4	5	3	3	0	0.541	1.000	1.000
258	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(1), PTK2(5), RAF1(1), ROCK2(4)	28644181	35	33	35	6	4	9	8	8	6	0	0.165	1.000	1.000
259	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2)	11650010	23	22	23	8	3	3	10	5	2	0	0.700	1.000	1.000
260	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), PRKCE(2), SOD1(1)	8911312	14	14	14	9	2	2	5	4	1	0	0.931	1.000	1.000
261	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(2), MMP9(1), RECK(1), TIMP3(1)	8432822	5	5	5	8	1	1	2	0	1	0	0.996	1.000	1.000
262	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ACY1(2), ADC(1), AGMAT(2), ALDH18A1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), ASS1(1), CPS1(7), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1), SRM(1)	32554963	44	42	44	9	4	11	16	10	3	0	0.0826	1.000	1.000
263	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	71	B2M(3), CALR(1), CANX(2), CD4(4), CD8A(2), CIITA(1), CREB1(1), CTSB(1), CTSS(1), HLA-A(4), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR2DS4(3), KIR3DL1(1), KIR3DL2(5), KIR3DL3(1), KLRC1(3), KLRC3(1), LTA(1), NFYB(1), NFYC(2), RFX5(1), RFXANK(2), TAP1(2)	44678898	82	77	81	16	8	21	27	9	17	0	0.0324	1.000	1.000
264	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	8682726	10	10	10	6	2	3	1	3	1	0	0.797	1.000	1.000
265	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(2), CTH(3), GGT1(3), MARS(2), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1)	13522198	18	18	17	6	5	6	2	1	4	0	0.343	1.000	1.000
266	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	11	CHUK(1), IKBKAP(7), IKBKB(4), NFKB1(4), NFKBIA(1), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(3)	17451010	25	24	25	7	2	8	8	2	4	1	0.415	1.000	1.000
267	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), CHPT1(3), ENPP2(8), ENPP6(1), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PPAP2A(1), PPAP2C(2)	26002660	49	46	49	10	7	8	16	12	6	0	0.0822	1.000	1.000
268	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	14	FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NEU2(1)	21041196	26	25	26	7	3	5	8	6	4	0	0.394	1.000	1.000
269	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(3), ALDH5A1(1), CAD(10), CPS1(7), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GLS(2), GLUL(1), GMPS(2), GPT(3), GPT2(2), GSS(2), PPAT(1), QARS(3)	37403080	51	48	51	9	7	9	18	13	4	0	0.0560	1.000	1.000
270	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	BPNT1(1), CHST11(2), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3)	9737147	11	11	11	6	4	5	0	1	1	0	0.807	1.000	1.000
271	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(4), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1)	16584567	18	18	18	8	6	1	5	1	5	0	0.915	1.000	1.000
272	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	16	CHUK(1), IKBKAP(7), IKBKB(4), LTA(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFAIP3(2), TRAF1(1), TRAF3(2)	21813684	29	28	29	8	3	9	11	0	5	1	0.294	1.000	1.000
273	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4)	9652345	10	10	10	5	2	3	3	1	1	0	0.797	1.000	1.000
274	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1)	12315093	18	18	18	9	4	6	3	2	3	0	0.858	1.000	1.000
275	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTAP(1), MTR(5), SRM(1), TAT(2)	22905639	33	32	33	9	8	7	7	4	7	0	0.267	1.000	1.000
276	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), WASF1(5), WASL(1)	9313728	13	12	13	7	1	5	6	0	1	0	0.931	1.000	1.000
277	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(2), CRHR2(1), ELTD1(4), EMR1(2), EMR2(5), GHRHR(2), GIPR(1), GLP2R(2), GPR64(6), LPHN1(3), LPHN2(6), LPHN3(8), VIPR2(1)	31085123	52	50	52	12	6	5	23	7	10	1	0.164	1.000	1.000
278	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTR(5)	19283356	28	27	28	8	7	5	6	4	6	0	0.330	1.000	1.000
279	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(3), GRB2(1), IL3RA(2), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5)	19554918	28	28	28	9	7	3	7	3	8	0	0.451	1.000	1.000
280	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), DRD2(2), GRM1(5), PLCB1(4), PPP2CA(2), PPP3CA(4), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	17668255	25	24	25	8	3	3	9	4	6	0	0.695	1.000	1.000
281	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(4), ALDOB(2), ALDOC(1), G6PD(2), GPI(2), H6PD(2), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TAL1(1), TKT(2)	21820367	29	29	29	8	7	5	4	7	6	0	0.259	1.000	1.000
282	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	14	CD28(1), CD3E(2), CD3G(2), CD86(2), CTLA4(1), GRB2(1), ICOS(1), IL2(1), ITK(4), LCK(1), PTPN11(1)	9394419	17	17	17	6	3	6	6	2	0	0	0.529	1.000	1.000
283	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	21	ABL1(5), ATM(18), ATR(6), CCNA1(1), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), E2F1(4), HDAC1(4), SKP2(1), TFDP1(2), TGFB1(2), TGFB3(1)	29820484	50	47	49	10	6	9	9	10	16	0	0.214	1.000	1.000
284	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(4), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF5(2)	12921433	13	13	13	7	1	4	4	2	2	0	0.940	1.000	1.000
285	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(3)	13170738	17	17	17	5	3	2	5	5	2	0	0.652	1.000	1.000
286	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), CS(1), OGDH(4), SUCLA2(1)	10873579	9	8	9	4	0	3	5	1	0	0	0.706	1.000	1.000
287	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	36	AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), DAG1(1), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CD(4), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4)	51179768	83	77	83	14	17	16	23	13	13	1	0.00802	1.000	1.000
288	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(3), LDLR(1), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(1), SREBF2(4)	12265663	17	17	17	7	0	5	8	2	2	0	0.696	1.000	1.000
289	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	13	CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2B(1), MEF2C(3), MEF2D(2), NTRK1(4), PLCG1(6), RPS6KA1(2), SHC1(1)	15036995	23	22	23	9	8	2	6	3	4	0	0.595	1.000	1.000
290	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	13	AKT2(3), AKT3(4), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), PTK2B(3), RBL2(1), SHC1(1), SOS1(4)	17840738	27	26	27	7	5	7	7	2	6	0	0.320	1.000	1.000
291	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8)	18518416	23	22	23	6	2	4	8	4	5	0	0.504	1.000	1.000
292	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(6), NTRK1(4), PIR(2), PSMA7(1), WASF1(5), WASF3(1), WASL(1)	17398517	28	27	28	8	4	7	12	4	1	0	0.521	1.000	1.000
293	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(3), IDI1(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1)	14617273	12	12	12	9	2	1	5	1	3	0	0.988	1.000	1.000
294	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	30	A1BG(2), AKT2(3), AKT3(4), BTK(4), GRB2(1), GSK3A(3), IARS(7), INPP5D(4), PDK1(1), PPP1R13B(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SOS1(4), SOS2(4), TEC(2), YWHAB(1), YWHAG(1), YWHAZ(1)	35776593	58	55	58	11	15	10	18	8	7	0	0.0423	1.000	1.000
295	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	EHHADH(3), HADH(2), HSD17B10(1), HSD17B4(6), NTAN1(1), SIRT1(2), SIRT2(1), SIRT7(3), VNN2(4)	13344017	23	23	23	8	1	7	10	4	1	0	0.708	1.000	1.000
296	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	19	ADCY1(3), BAX(2), CSF2RB(3), IGF1(1), IGF1R(2), IL3RA(2), KIT(5), KITLG(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	18854369	28	27	27	9	4	6	9	3	6	0	0.520	1.000	1.000
297	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(6), ACO1(2), ACO2(3), IDH1(2), MDH2(1), SUCLA2(1)	15097889	15	14	15	5	3	2	5	4	1	0	0.518	1.000	1.000
298	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ARPC1A(1), ARPC1B(2), ARPC2(2), PAK1(2), PDGFRA(3), WASL(1)	11118120	11	11	11	8	2	4	4	0	1	0	0.982	1.000	1.000
299	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), CS(1), DLD(1), DLST(3), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), PC(5), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK4(2), PDP2(1), SDHB(1), SUCLA2(1)	32078177	36	34	36	7	6	9	12	7	2	0	0.0960	1.000	1.000
300	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	29	MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CD(4), TRAF3(2), TRAF5(1), TRAF6(3)	29319913	36	34	36	8	8	7	7	6	6	2	0.133	1.000	1.000
301	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	24	AKT2(3), AKT3(4), CISH(1), GRB2(1), IARS(7), IL13RA1(1), IL2RG(1), IL4R(4), INPP5D(4), JAK1(4), JAK2(5), JAK3(5), NR0B2(2), PI3(1), PPP1R13B(3), RPS6KB1(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), STAT6(2), TYK2(5)	37263371	67	61	67	13	14	10	19	9	15	0	0.0741	1.000	1.000
302	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(4), ALDOB(2), ALDOC(1), DERA(1), G6PD(2), GPI(2), H6PD(2), PFKL(1), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(2), TKTL1(2), TKTL2(1)	26336666	33	33	33	9	7	5	5	8	8	0	0.243	1.000	1.000
303	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(7), EP300(7), IKBKB(4), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), NFKB1(4), NFKBIA(1), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1)	33002551	39	36	38	9	7	10	10	4	8	0	0.160	1.000	1.000
304	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	8	EGF(3), EGFR(5), MAP2K1(1), MAPK14(2), RARA(2), RXRA(1), THRA(1), THRB(1)	11562105	16	16	16	7	3	4	4	4	1	0	0.785	1.000	1.000
305	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	23	ARHGDIB(1), BAG4(1), CASP2(3), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MADD(10), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), RIPK1(3), SPTAN1(4), TNFRSF1A(1)	36619449	47	44	47	9	7	11	12	6	11	0	0.0928	1.000	1.000
306	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(4), EGF(3), EGFR(5), HGS(4), TF(3), TFRC(1)	14360966	20	20	20	9	5	3	7	3	2	0	0.851	1.000	1.000
307	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	15	C3(7), C5(4), C6(5), C7(6), ICAM1(1), IL1A(1), IL6(2), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELP(8), VCAM1(4)	27012669	48	45	48	13	6	8	15	12	7	0	0.333	1.000	1.000
308	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(4), ACTG2(2), ADCY3(3), ADCY9(9), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(3), PLCG1(6), PLCG2(3), SEC61A1(2), TRIM23(4)	41585883	61	57	61	11	10	7	23	9	12	0	0.0578	1.000	1.000
309	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(18), ATR(6), BRCA1(12), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), CHEK2(3), EP300(7), MDM2(2), MYT1(5), PRKDC(10), RPS6KA1(2), WEE1(2)	48243344	75	71	74	13	10	11	18	14	22	0	0.0674	1.000	1.000
310	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	61	APAF1(3), BAK1(2), BAX(2), BCL2L11(4), BID(4), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IRF1(1), IRF3(3), IRF5(1), IRF6(2), IRF7(1), JUN(3), LTA(1), MAPK10(2), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TP73(1), TRAF1(1), TRAF3(2)	55252649	75	70	74	10	11	22	16	7	18	1	0.00177	1.000	1.000
311	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	28246967	33	32	33	9	6	7	8	9	2	1	0.393	1.000	1.000
312	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	30	CHUK(1), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL1RN(3), IL6(2), IRAK1(2), IRAK2(3), IRAK3(1), JUN(3), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TGFB1(2), TGFB3(1), TRAF6(3)	29968007	50	45	50	11	10	15	11	5	9	0	0.107	1.000	1.000
313	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
314	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
315	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1)	17343659	16	16	16	7	3	1	7	1	4	0	0.879	1.000	1.000
316	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	18	EIF4A2(6), EIF4G1(2), EIF4G2(2), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK14(2), MAPK3(1), PABPC1(3), PDK2(2), RPS6KB1(2)	24785683	29	28	29	7	4	11	8	0	6	0	0.309	1.000	1.000
317	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD28(1), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18R1(2), IL2(1), IL4R(4), TGFB1(2), TGFB3(1)	22974004	41	40	41	12	6	8	10	8	9	0	0.330	1.000	1.000
318	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), NPAS2(2), NR1D1(2), PER1(3), PER2(3), PER3(3)	18523950	20	20	20	6	5	2	4	5	4	0	0.570	1.000	1.000
319	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NQO2(2), PMVK(1), SQLE(1), VKORC1(1)	12144925	11	11	11	8	3	2	5	0	1	0	0.973	1.000	1.000
320	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGW(3), PIGZ(2)	27747967	29	27	29	7	7	5	9	6	2	0	0.228	1.000	1.000
321	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	16	ADCY1(3), ARHGEF1(7), F2(4), F2R(3), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PLCB1(4), PPP1R12B(1), PTK2B(3), ROCK1(4)	24108587	33	33	33	9	3	9	14	3	4	0	0.381	1.000	1.000
322	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	26	ACAA2(2), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), SRD5A1(1)	25713190	30	29	30	9	5	9	11	4	1	0	0.401	1.000	1.000
323	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	15	EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), IGF1(1), IGF1R(2), INPPL1(4), PDK2(2), PPP2CA(2), RPS6(2), RPS6KB1(2)	15804730	21	21	21	7	3	7	7	1	3	0	0.503	1.000	1.000
324	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	18537327	23	22	23	8	3	4	5	8	2	1	0.694	1.000	1.000
325	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), FDXR(1)	18175410	17	17	17	7	3	1	8	1	4	0	0.852	1.000	1.000
326	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	12	GRB2(1), IGF1R(2), IRS1(2), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4)	15051990	14	14	14	7	2	6	2	2	2	0	0.765	1.000	1.000
327	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(4), AARS2(4), CARS2(2), DARS(1), DARS2(2), EARS2(3), EPRS(4), FARS2(1), FARSA(1), FARSB(3), GARS(1), HARS(1), IARS(7), IARS2(2), LARS(2), LARS2(2), MARS(2), NARS(1), NARS2(2), PARS2(1), QARS(3), RARS(3), RARS2(2), SARS(3), SARS2(2), TARS(5), TARS2(6), WARS2(1), YARS2(1)	58540245	72	67	72	10	16	16	22	12	6	0	0.00430	1.000	1.000
328	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(2), CAMK2D(4), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFAT5(6), PDE6A(1), PDE6B(2), PDE6C(6), SLC6A13(3), TF(3)	40189530	60	60	60	13	4	14	16	17	9	0	0.0836	1.000	1.000
329	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	45	APAF1(3), BAX(2), BCL2L2(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFB(2), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(4), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(4), PTPN13(5), RIPK1(3), SFRS2IP(4), TFG(1), TNFRSF1A(1), TRAF1(1), TRAF3(2), TRAF6(3)	46896270	60	55	59	10	7	19	14	6	13	1	0.0126	1.000	1.000
330	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	21	BTK(4), DLG4(1), EPHB2(3), F2(4), F2RL2(1), JUN(3), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(3), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RAF1(1), RASAL1(2), TEC(2), VAV1(4)	30484081	47	42	47	10	8	9	15	6	9	0	0.123	1.000	1.000
331	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1)	22592624	26	25	26	9	5	6	7	2	6	0	0.586	1.000	1.000
332	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX12(2), ALOX15(2), ALOX5(1), CBR1(1), CYP4F2(2), EPX(4), GGT1(3), LPO(5), MPO(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(5)	30875978	51	49	50	11	15	5	16	7	8	0	0.0792	1.000	1.000
333	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	66	MRPL13(1), MRPS7(2), RPL10L(2), RPL13A(3), RPL14(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPL8(1), RPS10(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS5(4), RPS6(2), RPSA(1)	25173384	38	36	37	9	5	5	14	7	7	0	0.537	1.000	1.000
334	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(2), CHST3(1), CHSY1(1), DSE(8), UST(3), XYLT1(2), XYLT2(1)	13357388	22	22	22	8	9	5	4	3	1	0	0.508	1.000	1.000
335	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(6), CD2(3), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), ITGAX(5), TLR2(1), TLR7(8), TLR9(1)	18851210	33	33	33	10	8	8	3	7	7	0	0.338	1.000	1.000
336	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), ARHGEF1(7), GNAQ(1), GNB1(1), MYLK(8), PLCB1(4), PPP1R12B(1), ROCK1(4)	23463001	29	29	29	8	4	7	9	4	5	0	0.384	1.000	1.000
337	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(4), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MOS(3), NFKB1(4), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), SHC1(1), SOS1(4), SOS2(4), TRAF3(2)	33045893	50	46	50	11	14	8	12	8	7	1	0.0846	1.000	1.000
338	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADVL(3), ACSL1(1), ACSL3(1), ACSL4(2), CPT1A(4), CPT2(5), EHHADH(3), SLC25A20(1)	18856392	20	20	20	7	3	7	5	2	3	0	0.643	1.000	1.000
339	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ARG1(2), ARG2(1), ASL(4), ASS1(1), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), EPRS(4), GAMT(1), GATM(4), GLUD2(2), LAP3(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), PARS2(1), PRODH(1), PYCR2(1), RARS(3), RARS2(2)	39433355	56	55	56	11	11	10	23	8	4	0	0.0639	1.000	1.000
340	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(3), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	19910024	21	21	21	9	2	4	4	8	3	0	0.782	1.000	1.000
341	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(6), JAK1(4), JAK2(5), JAK3(5), JUN(3), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(3)	26223925	43	40	43	10	6	7	12	7	11	0	0.272	1.000	1.000
342	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(3), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(6), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(3), PLCB1(4), PTK2(5), SMPD1(1)	25102326	30	28	30	9	5	8	7	5	5	0	0.521	1.000	1.000
343	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	28	CD14(2), CHUK(1), ELK1(2), IKBKB(4), IRAK1(2), JUN(3), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), PPARA(2), RELA(1), TIRAP(1), TLR10(1), TLR2(1), TLR3(5), TLR7(8), TLR9(1), TRAF6(3)	34235851	50	48	50	12	9	12	11	6	12	0	0.137	1.000	1.000
344	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(7), EP300(7), IL2RG(1), IL7R(4), JAK1(4), JAK3(5), LCK(1), PTK2B(3), STAT5A(4), STAT5B(5)	27148762	41	39	40	10	7	5	13	7	9	0	0.238	1.000	1.000
345	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(2), BCR(3), BLNK(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(9), RPS6KA1(2), RPS6KA3(4), SHC1(1), SOS1(4), SYK(2), VAV1(4), VAV2(2), VAV3(4)	31488213	54	51	54	13	16	9	16	7	6	0	0.0932	1.000	1.000
346	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	20	F2(4), F2R(3), GNAI1(1), GNB1(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(2), PTK2(5), RAF1(1), SYK(2), TBXAS1(1)	27122565	42	37	42	11	5	7	21	6	3	0	0.444	1.000	1.000
347	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(2), CTH(3), GGT1(3), HEMK1(1), LCMT1(1), LCMT2(5), MARS(2), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2)	27059148	44	39	43	12	11	15	10	1	7	0	0.113	1.000	1.000
348	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(2), ATG7(3), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNG(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(3), ULK1(1), ULK2(4), ULK3(2)	23553425	40	39	40	10	3	11	16	6	4	0	0.389	1.000	1.000
349	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	18	CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(4), RAF1(1), RALBP1(1), RALGDS(1), RELA(1), RHOA(2)	16070650	16	16	16	7	5	4	3	3	1	0	0.662	1.000	1.000
350	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	30	AKT2(3), AKT3(4), BCR(3), BTK(4), CD19(3), FLOT1(1), FLOT2(2), GAB1(2), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), NR0B2(2), PDK1(1), PHF11(1), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(10), PTPRC(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SAG(1), SYK(2), TEC(2), VAV1(4)	57592385	96	86	96	19	20	17	28	18	13	0	0.00975	1.000	1.000
351	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(3), ADC(1), ALDH5A1(1), CAD(10), CPS1(7), EARS2(3), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD2(2), GLUL(1), GMPS(2), GNPNAT1(2), GPT(3), GPT2(2), GSS(2), NAGK(1), PPAT(1), QARS(3)	44573096	63	59	63	13	10	11	20	17	5	0	0.0667	1.000	1.000
352	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	30	APAF1(3), BID(4), BIRC3(1), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DFFB(2), LMNA(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF25(1)	35577718	30	29	30	6	6	10	5	2	7	0	0.135	1.000	1.000
353	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	35	ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(3), DEGS2(1), ENPP7(3), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD1(1), SMPD3(1), SMPD4(1), SPHK2(2), SPTLC1(2), SPTLC2(2), UGT8(2)	36669335	50	47	50	12	8	9	14	12	6	1	0.205	1.000	1.000
354	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	21	ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), PRDX1(1), PRDX5(1), TAT(2), TPO(5)	23609061	36	34	36	10	11	5	8	4	8	0	0.271	1.000	1.000
355	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	18	CHUK(1), IKBKB(4), IL1A(1), IL1R1(1), IRAK1(2), MAP3K7(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TNFAIP3(2), TNFRSF1A(1), TRAF6(3)	21045143	25	24	25	9	3	8	7	4	3	0	0.622	1.000	1.000
356	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(6), ACO1(2), ACO2(3), CLYBL(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), OGDHL(4), PC(5), PCK1(2), PCK2(3), SDHB(1), SUCLA2(1)	33848098	46	42	46	10	7	9	18	10	2	0	0.0874	1.000	1.000
357	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3), MASP2(2), MBL2(1)	23892391	34	33	34	10	6	7	10	4	7	0	0.369	1.000	1.000
358	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	48	ACTG1(4), APAF1(3), ARHGDIB(1), BAG4(1), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DAXX(2), DFFB(2), GSN(1), LMNA(1), LMNB1(1), MAP2K7(1), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(4), NFKBIA(1), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(10), PSEN1(1), PSEN2(3), PTK2(5), RASA1(2), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF1A(1), TRAF1(1)	71008644	81	77	81	11	14	18	19	11	19	0	0.00348	1.000	1.000
359	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), B4GALT1(2), G6PC(1), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(2), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKL(1), PFKM(4), PFKP(2), PGM1(1), PGM3(1), RDH11(2), RDH12(1), RDH14(2), UGP2(1)	42158438	64	62	64	16	11	12	11	20	10	0	0.0724	1.000	1.000
360	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(1), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), NOS1(7), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	28078190	52	48	52	15	10	4	23	7	8	0	0.344	1.000	1.000
361	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	12	ERCC3(2), GTF2A1(1), HDAC3(1), NCOA1(2), NCOA2(3), POLR2A(5), RARA(2), RXRA(1), TBP(1)	20466652	18	18	18	7	3	2	5	5	3	0	0.758	1.000	1.000
362	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), MDH2(1), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGK1(3), PKLR(3), PKM2(1), TPI1(2)	46892082	55	53	55	11	9	17	12	10	7	0	0.0114	1.000	1.000
363	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BTK(4), ELK1(2), FCER1A(4), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PAK2(2), PLA2G4A(7), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4)	38550720	69	63	69	17	11	16	20	11	11	0	0.135	1.000	1.000
364	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	37	ACAA2(2), ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), LIPA(1), RDH11(2), RDH12(1), RDH14(2), SLC27A5(3), SOAT1(1), SRD5A1(1)	35106899	40	40	40	10	7	12	11	7	3	0	0.171	1.000	1.000
365	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	22	ATM(18), BMPR1B(3), CDK4(1), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), INHA(1), LHCGR(5), MLH1(3), MSH5(2), NRIP1(3), PGR(4), PRLR(1), SMPD1(1), ZP2(2)	31750001	54	49	54	14	5	12	12	12	13	0	0.345	1.000	1.000
366	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	47	ADORA3(2), ALG6(1), CCKBR(1), CCR2(5), CCR3(1), CCR5(2), CELSR1(6), CELSR2(10), CELSR3(7), CHRM2(4), CHRM3(1), CIDEB(2), CXCR3(5), EDNRA(1), EMR2(5), EMR3(3), F2R(3), FSHR(4), GHRHR(2), GPR116(3), GPR132(2), GPR133(2), GPR143(4), GPR17(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(3), GRM1(5), GRPR(1), HRH4(1), LGR6(3), LPHN2(6), LPHN3(8), LTB4R2(1), P2RY11(1), P2RY13(3), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4)	67413213	125	108	126	28	24	25	27	26	23	0	0.00397	1.000	1.000
367	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	31	AKT2(3), AKT3(4), ARHGEF11(3), DLG4(1), LPA(11), MAP3K5(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(6), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RDX(1), ROCK1(4), ROCK2(4), SERPINA4(3), SRF(1)	49243632	79	68	79	15	15	16	27	5	15	1	0.0288	1.000	1.000
368	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(12), CARM1(2), CCND1(1), CREBBP(7), EP300(7), ERCC3(2), ESR1(3), GRIP1(3), GTF2A1(1), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), MEF2C(3), NRIP1(3), PELP1(2), POLR2A(5), SRA1(1), TBP(1)	47958414	72	68	71	17	8	16	19	8	21	0	0.205	1.000	1.000
369	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	28	ARSB(4), FUCA2(1), GALNS(1), GBA(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NAGLU(1), NEU2(1), SPAM1(2)	36479856	54	50	54	14	8	10	17	11	8	0	0.264	1.000	1.000
370	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	24	APC(5), ASAH1(1), CERK(1), CREB1(1), CREB3(1), CREB5(1), DAG1(1), EPHB2(3), GNAQ(1), ITPKA(1), ITPKB(7), JUN(3), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3)	29155321	39	38	39	11	8	5	8	10	8	0	0.437	1.000	1.000
371	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	54042472	64	62	64	14	12	20	17	10	5	0	0.0192	1.000	1.000
372	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	52	ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	54042472	64	62	64	14	12	20	17	10	5	0	0.0192	1.000	1.000
373	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX15(2), ALOX5(1), CYP1A2(3), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(2)	26952869	43	41	42	12	7	7	14	7	8	0	0.293	1.000	1.000
374	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(3), ATM(18), ATR(6), BAI1(9), BAX(2), BID(4), CASP9(1), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CHEK2(3), DDB2(1), EI24(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), MDM4(3), PERP(2), PPM1D(2), RCHY1(1), RRM2(1), SERPINE1(3), SESN2(2), SIAH1(3), STEAP3(2), THBS1(4), TP53I3(1), TP73(1), TSC2(2)	67853243	107	92	106	21	18	18	19	23	29	0	0.0816	1.000	1.000
375	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	25	ADRBK1(2), AKT2(3), AKT3(4), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PIK3CB(6), PITX2(3), PLD1(5), PLD2(2), PLD3(2)	48106413	79	70	79	19	11	16	23	15	13	1	0.0806	1.000	1.000
376	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	18	EXT1(5), EXT2(6), EXTL3(4), GLCE(4), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST2(5), HS6ST3(1), NDST3(2)	22372477	36	34	36	10	5	5	8	11	7	0	0.465	1.000	1.000
377	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(4), JAK3(5), JUN(3), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2)	25808241	41	39	41	12	9	5	12	5	10	0	0.311	1.000	1.000
378	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AGK(2), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DAK(3), DGAT1(1), DGAT2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), GK(1), GK2(3), GLA(4), GLB1(2), GPAM(1), LCT(11), LIPA(1), LIPC(1), LIPF(2), LIPG(1), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(3), PNPLA3(2), PPAP2A(1), PPAP2C(2)	65416087	99	91	97	24	22	20	24	17	15	1	0.0512	1.000	1.000
379	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), BTRC(2), CDC20(1), CDC23(1), CUL1(2), CUL3(2), FBXW7(6), ITCH(1), SKP2(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(4), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(7)	43712872	54	50	54	11	10	18	9	9	7	1	0.0891	1.000	1.000
380	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MPL(1), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5)	29441980	40	39	40	10	8	6	8	5	13	0	0.317	1.000	1.000
381	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AP2A1(6), AP2M1(4), ARF1(1), BTK(4), EEA1(4), GRASP(1), GSK3A(3), LYN(4), PFKL(1), PFKM(4), PFKP(2), PLCG1(6), PRKCE(2), PRKCZ(1), RPS6KB1(2), VAV2(2)	26651480	47	46	47	14	9	8	10	8	12	0	0.353	1.000	1.000
382	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	36	ACACA(4), ACAT1(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1)	40700821	43	37	43	10	8	14	13	5	3	0	0.113	1.000	1.000
383	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	40	ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AMDHD1(3), AOC2(1), AOC3(3), ASPA(2), CARM1(2), CNDP1(3), DDC(1), FTCD(1), HAL(2), HARS(1), HEMK1(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), PRPS2(1), UROC1(2), WBSCR22(2)	42772465	55	48	55	14	9	15	20	3	8	0	0.125	1.000	1.000
384	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPOR(4), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5)	24004079	41	39	41	12	9	6	10	4	12	0	0.334	1.000	1.000
385	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	38	ARNTL(2), AZIN1(1), CBX3(3), CLOCK(1), CRY1(1), CRY2(1), EIF4G2(2), ETV6(2), G0S2(1), GSTP1(1), HSPA8(4), IDI1(2), MYF6(3), NCKAP1(6), NR1D2(1), PER1(3), PER2(3), PPP1R3C(1), PPP2CB(3), TOB1(3), TUBB3(1), UCP3(2), UGP2(1), VAPA(1), ZFR(6)	40488934	55	51	55	13	4	12	19	9	11	0	0.350	1.000	1.000
386	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), F2(4), F2R(3), F5(14), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), PROC(1), PROS1(1), SERPINC1(4), SERPING1(2)	50584894	77	72	77	20	10	15	30	12	10	0	0.319	1.000	1.000
387	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	41	ACACA(4), ACACB(9), ACAT1(2), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PCK2(3), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1)	51688159	51	46	51	10	9	12	17	9	4	0	0.0538	1.000	1.000
388	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), OCRL(6), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CB(6), PIK3CG(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3)	47771228	78	75	78	19	13	16	22	14	13	0	0.126	1.000	1.000
389	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	32	ATF2(2), DLD(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(1), JUN(3), MAP2K5(2), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK10(2), MAPK8(2), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(9), SHC1(1), TRAF6(3), ZAK(2)	45270315	66	60	66	16	15	10	14	9	18	0	0.233	1.000	1.000
390	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	ASAH1(1), ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), CREBBP(7), CRKL(1), DAG1(1), EGR1(1), EGR2(2), EGR3(2), ELK1(2), GNAQ(1), JUN(3), MAP1B(3), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NTRK1(4), OPN1LW(1), PIK3C2G(3), PIK3CD(4), PTPN11(1), RPS6KA3(4), SHC1(1), TERF2IP(3), TH(1)	49471476	68	65	68	18	16	6	19	12	15	0	0.308	1.000	1.000
391	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	22	AKT2(3), AKT3(4), GRB2(1), GSK3A(3), IL4R(4), IRS1(2), JAK1(4), JAK3(5), MAP4K1(4), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), PPP1R13B(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), STAT6(2)	32888932	52	48	52	14	10	9	14	9	10	0	0.282	1.000	1.000
392	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP5(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), PON1(1)	32341955	56	47	53	16	11	8	21	9	7	0	0.323	1.000	1.000
393	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	187	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT2(3), AKT3(4), ARHGAP5(3), BCAR1(2), BIRC3(1), BRAF(3), CAPN2(3), CAV1(2), CCND1(1), CCND3(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), CRK(1), CRKL(1), CTNNB1(1), DIAPH1(4), EGF(3), EGFR(5), ELK1(2), FARP2(5), FIGF(2), FLNA(5), FLNB(13), FLNC(10), FLT1(2), FN1(5), GRB2(1), GRLF1(7), HGF(4), IBSP(2), IGF1(1), IGF1R(2), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), JUN(3), KDR(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MET(7), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARVA(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP5K1C(4), PPP1R12A(3), PRKCG(2), PTK2(5), RAF1(1), RAPGEF1(4), RELN(19), RHOA(2), ROCK1(4), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TLN1(12), TLN2(5), TNC(6), TNN(6), TNR(6), TNXB(7), VAV1(4), VAV2(2), VAV3(4), VCL(4), VTN(1), VWF(10)	397797112	560	344	558	192	107	115	157	83	98	0	0.652	1.000	1.000
394	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(3), ADCY3(3), ADCY4(2), ADCY7(7), ADCY8(7), ADCY9(9), ADORA2A(2), ADRA1A(2), ADRA1B(1), ADRB2(1), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), ATP2B4(3), AVPR1B(2), BDKRB1(2), BDKRB2(1), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CCKAR(1), CCKBR(1), CD38(3), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(2), EDNRA(1), EDNRB(2), EGFR(5), ERBB3(11), ERBB4(6), F2R(3), GNA14(1), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(12), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), GRPR(1), HRH1(2), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), LHCGR(5), LTB4R2(1), MYLK(8), MYLK2(2), NOS1(7), NOS3(3), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), PDE1A(2), PDE1B(2), PDE1C(2), PDGFRA(3), PDGFRB(3), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PLN(1), PPID(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(16), RYR2(32), RYR3(24), SLC25A4(1), SLC25A5(3), SLC8A1(3), SLC8A3(1), SPHK2(2), TACR1(1), TACR2(2), TACR3(1), TNNC2(1), TRPC1(3), VDAC2(2)	300316246	524	333	519	189	129	73	160	106	55	1	0.473	1.000	1.000
395	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	238	ACVR1B(6), ACVR1C(2), AKT2(3), AKT3(4), ARRB1(1), ARRB2(1), ATF2(2), ATF4(2), BDNF(1), BRAF(3), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CACNA2D1(5), CACNA2D2(4), CACNA2D3(5), CACNA2D4(2), CACNB1(2), CACNB2(3), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(1), CD14(2), CDC25B(3), CHUK(1), CRK(1), CRKL(1), DAXX(2), DUSP10(2), DUSP16(5), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(3), EGFR(5), ELK1(2), FAS(1), FASLG(2), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(7), FGFR3(2), FGFR4(4), FLNA(5), FLNB(13), FLNC(10), GRB2(1), IKBKB(4), IL1A(1), IL1R1(1), IL1R2(5), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K10(4), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAPT(3), MAX(3), MEF2C(3), MOS(3), MYC(1), NF1(20), NFATC2(2), NFATC4(5), NFKB1(4), NFKB2(3), NLK(2), NR4A1(1), NRAS(1), NTRK1(4), NTRK2(6), PAK1(2), PAK2(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(1), PPM1B(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PPP5C(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(3), RASA1(2), RASA2(2), RASGRF1(4), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KA6(3), SOS1(4), SOS2(4), SRF(1), STK3(1), STK4(3), TAOK1(5), TAOK2(1), TAOK3(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TRAF6(3), ZAK(2)	309373725	490	305	487	164	105	83	134	79	87	2	0.362	1.000	1.000
396	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	196	ABI2(1), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), APC(5), ARAF(4), ARHGEF1(7), ARHGEF12(2), ARHGEF4(4), ARHGEF6(4), ARHGEF7(2), ARPC1A(1), ARPC1B(2), ARPC2(2), BCAR1(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CRK(1), CRKL(1), CYFIP1(2), CYFIP2(7), DIAPH1(4), DIAPH2(4), DIAPH3(3), EGF(3), EGFR(5), EZR(3), F2(4), F2R(3), FGD3(3), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR2(7), FGFR3(2), FGFR4(4), FN1(5), GIT1(1), GRLF1(7), GSN(1), IQGAP1(2), IQGAP2(4), IQGAP3(6), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), LIMK1(4), LIMK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(3), MSN(2), MYH10(7), MYH14(11), MYH9(8), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), NCKAP1(6), NCKAP1L(5), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PPP1R12A(3), PPP1R12B(1), PTK2(5), RAF1(1), RDX(1), RHOA(2), ROCK1(4), ROCK2(4), SCIN(1), SLC9A1(1), SOS1(4), SOS2(4), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(4), VAV2(2), VAV3(4), VCL(4), WAS(3), WASF1(5), WASL(1)	304676757	416	289	412	154	80	75	114	79	68	0	0.889	1.000	1.000
397	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), ACTG1(4), COL11A1(4), COL11A2(1), COL17A1(5), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), DSC1(2), DSC2(5), DSC3(1), DSG1(3), DSG2(1), DSG3(5), DSG4(4), FN1(5), GJA1(2), GJA10(1), GJA4(1), GJA5(3), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GJC1(1), GJD4(1), IBSP(2), INA(1), ITGA6(4), ITGB4(4), KRT1(6), KRT14(2), KRT15(1), KRT17(4), KRT18(1), KRT19(3), KRT2(2), KRT20(1), KRT24(1), KRT25(1), KRT28(5), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT34(2), KRT35(1), KRT36(2), KRT38(4), KRT39(1), KRT4(2), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(2), KRT71(1), KRT72(2), KRT73(2), KRT74(1), KRT76(2), KRT78(1), KRT79(2), KRT81(2), KRT82(2), KRT84(4), KRT85(1), KRT86(2), KRT9(3), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), LMNA(1), LMNB1(1), NES(4), RELN(19), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(7), VIM(1), VTN(1), VWF(10)	271695437	386	279	382	133	77	81	113	49	66	0	0.483	1.000	1.000
398	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	230	ADCYAP1R1(1), ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(3), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(2), CCKAR(1), CCKBR(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CNR1(2), CNR2(1), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2(4), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(2), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(3), GABRG3(3), GABRP(1), GABRQ(3), GABRR1(1), GALR1(2), GALR2(2), GH1(1), GH2(4), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP2R(2), GLRA2(1), GLRA3(3), GPR156(3), GPR35(1), GPR50(2), GPR63(1), GPR83(4), GRIA1(8), GRIA2(3), GRIA3(10), GRIA4(5), GRID1(8), GRID2(6), GRIK1(6), GRIK2(9), GRIK3(4), GRIK4(1), GRIK5(5), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRIN3A(4), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM6(3), GRM7(3), GRM8(3), GRPR(1), GZMA(2), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HRH4(1), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LEPR(4), LHCGR(5), LTB4R2(1), MAS1(2), MC2R(2), MC3R(2), MC4R(2), MCHR2(2), NMBR(2), NMUR1(1), NMUR2(2), NPBWR1(1), NPFFR2(4), NPY1R(4), NPY2R(1), NR3C1(2), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(2), PARD3(4), PPYR1(1), PRLR(1), PRSS3(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(2), TACR1(1), TACR2(2), TACR3(1), THRA(1), THRB(1), TSHR(4), VIPR2(1)	237322171	412	276	412	145	103	56	141	68	43	1	0.250	1.000	1.000
399	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADRA1A(2), ADRA1B(1), ADRB2(1), ANXA6(4), ARRB1(1), ARRB2(1), ATP1A4(11), ATP1B1(2), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1S(5), CACNB1(2), CACNB3(1), CALR(1), CAMK1(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(3), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNB1(4), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(4), PKIG(1), PLCB3(3), PLN(1), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS9(4), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SLC8A3(1), USP5(4), YWHAB(1)	212849456	374	267	374	141	98	53	108	74	40	1	0.555	1.000	1.000
400	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	126	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT2(3), AKT3(4), AMOTL1(4), ASH1L(10), CASK(6), CDK4(1), CGN(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTTN(1), EPB41(3), EPB41L1(4), EPB41L2(2), EPB41L3(4), EXOC3(3), EXOC4(2), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), HCLS1(1), IGSF5(2), INADL(6), JAM3(1), LLGL1(1), LLGL2(4), MAGI1(10), MAGI2(9), MAGI3(4), MLLT4(12), MPDZ(6), MPP5(2), MYH1(8), MYH10(7), MYH11(10), MYH13(7), MYH14(11), MYH15(6), MYH2(3), MYH3(2), MYH4(6), MYH6(12), MYH7(10), MYH7B(11), MYH8(13), MYH9(8), MYL5(1), MYLPF(1), NRAS(1), PARD3(4), PARD6B(2), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP2R3A(3), PPP2R4(4), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), RAB13(1), RHOA(2), SPTAN1(4), SYMPK(5), TJP1(6), TJP2(1), TJP3(2), VAPA(1), YES1(2), ZAK(2)	215541664	347	254	341	114	72	50	106	53	65	1	0.620	1.000	1.000
401	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CD44(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), DAG1(1), FN1(5), FNDC1(9), FNDC3A(1), FNDC4(1), GP6(2), HMMR(1), HSPG2(8), IBSP(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), RELN(19), SDC2(2), SPP1(2), SV2A(3), SV2B(1), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(7), VTN(1), VWF(10)	243632272	332	246	331	124	63	73	96	45	55	0	0.832	1.000	1.000
402	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	247	ACVR1(1), ACVR1B(6), ACVR2A(4), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1B(3), BMPR2(3), CCL11(1), CCL13(2), CCL14(1), CCL20(1), CCL21(1), CCL23(1), CCL28(1), CCL7(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD40(1), CD40LG(1), CLCF1(1), CNTFR(1), CSF1(3), CSF2RA(2), CSF2RB(3), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL6(1), CXCR3(5), EDA(2), EDA2R(1), EDAR(2), EGF(3), EGFR(5), EPOR(4), FAS(1), FASLG(2), FLT1(2), FLT3(3), FLT3LG(1), FLT4(1), GH1(1), GH2(4), GHR(2), HGF(4), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(2), IL17RA(2), IL17RB(2), IL18(1), IL18R1(2), IL18RAP(3), IL19(1), IL1A(1), IL1R1(1), IL1R2(5), IL1RAP(7), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(1), INHBA(3), INHBB(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(3), LEPR(4), LIF(3), LIFR(7), LTA(1), MET(7), MPL(1), NGFR(1), OSMR(4), PDGFB(2), PDGFRA(3), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(4), TNFRSF19(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TNFRSF8(2), TNFRSF9(2), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(3), TPO(5), TSLP(1), XCL1(2), XCR1(4)	197085524	317	241	314	86	59	62	90	48	58	0	0.0131	1.000	1.000
403	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(5), ABLIM1(4), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(10), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(2), EPHA1(3), EPHA2(3), EPHA3(4), EPHA4(2), EPHA5(7), EPHA6(3), EPHA7(3), EPHA8(1), EPHB1(5), EPHB2(3), EPHB3(3), EPHB4(2), EPHB6(3), FES(2), GNAI1(1), GNAI2(2), GNAI3(1), ITGB1(3), L1CAM(4), LIMK1(4), LIMK2(2), LRRC4C(3), MAPK1(1), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NGEF(2), NRAS(1), NRP1(6), NTNG1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLXNA1(7), PLXNA2(5), PLXNA3(6), PLXNB1(2), PLXNB2(3), PLXNB3(4), PLXNC1(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PTK2(5), RASA1(2), RGS3(7), RHOA(2), RND1(1), ROBO1(8), ROBO2(7), ROBO3(1), ROCK1(4), ROCK2(4), SEMA3A(5), SEMA3B(1), SEMA3C(3), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(4), SEMA4C(1), SEMA4D(3), SEMA4F(6), SEMA4G(3), SEMA5A(8), SEMA5B(6), SEMA6A(4), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(1), SLIT2(6), SLIT3(3), SRGAP1(8), SRGAP2(5), SRGAP3(1), UNC5B(3), UNC5C(5), UNC5D(10)	210469091	318	241	318	91	62	63	100	42	51	0	0.0709	1.000	1.000
404	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	135	ACTA1(2), ACTA2(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ARRB1(1), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATP2A2(1), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(2), ETS2(5), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), MIB1(4), MYLK2(2), NFKB1(4), NOS1(7), NOS3(3), PDE4B(4), PDE4D(6), PKIG(1), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(3), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS9(4), RLN1(1), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SP1(3), TNXB(7), USP5(4), YWHAB(1)	190064098	303	237	303	111	73	40	91	59	40	0	0.591	1.000	1.000
405	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(2), ACTA2(2), ACTN2(9), ACTN3(1), ACTN4(6), DMD(28), FAM48A(1), MYBPC1(3), MYBPC2(4), MYBPC3(2), MYH3(2), MYH6(12), MYH7(10), MYH8(13), MYL1(1), MYOM1(4), NEB(25), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM2(2), TPM3(3), TPM4(1), TTN(155), VIM(1)	162286787	296	220	294	55	47	41	101	67	39	1	0.000727	1.000	1.000
406	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT2(3), AKT3(4), CBL(4), CBLB(10), CBLC(2), CCND1(1), CCND3(2), CISH(1), CLCF1(1), CNTFR(1), CREBBP(7), CSF2RA(2), CSF2RB(3), CSF3R(3), EP300(7), EPOR(4), GH1(1), GH2(4), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL13RA2(4), IL15(2), IL19(1), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(1), IRF9(3), JAK1(4), JAK2(5), JAK3(5), LEPR(4), LIF(3), LIFR(7), MPL(1), MYC(1), OSMR(4), PIAS1(2), PIAS2(4), PIAS4(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(1), SOS1(4), SOS2(4), SPRED1(3), SPRED2(1), SPRY1(1), SPRY2(1), SPRY3(3), STAM(2), STAM2(2), STAT1(1), STAT2(2), STAT3(3), STAT4(6), STAT5A(4), STAT5B(5), STAT6(2), TPO(5), TSLP(1), TYK2(5)	156790250	270	205	268	58	46	48	79	42	55	0	0.00177	1.000	1.000
407	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	124	ACACA(4), ACACB(9), AKT2(3), AKT3(4), ARAF(4), BRAF(3), CBL(4), CBLB(10), CBLC(2), CRK(1), CRKL(1), ELK1(2), EXOC7(2), FASN(8), FLOT1(1), FLOT2(2), G6PC(1), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(4), INPP5D(4), INSR(4), IRS1(2), IRS4(6), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), NRAS(1), PCK1(2), PCK2(3), PDE3A(8), PDE3B(2), PFKL(1), PFKM(4), PFKP(2), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PKLR(3), PKM2(1), PPARGC1A(5), PPP1R3A(8), PPP1R3B(2), PPP1R3C(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(2), PRKACG(1), PRKAG2(1), PRKAG3(3), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(2), PTPRF(6), PYGB(3), PYGL(2), PYGM(5), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(2), SORBS1(5), SOS1(4), SOS2(4), SREBF1(1), TRIP10(5), TSC1(4), TSC2(2)	166594639	264	205	264	86	51	51	69	46	47	0	0.438	1.000	1.000
408	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NME4(1), NME6(1), NME7(4), NPR1(3), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(2), PDE10A(6), PDE11A(4), PDE1A(2), PDE1C(2), PDE2A(4), PDE3B(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1), XDH(4)	182345593	254	195	253	85	50	37	85	47	35	0	0.590	1.000	1.000
409	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	123	ALCAM(4), CADM1(3), CADM3(1), CD2(3), CD22(1), CD226(3), CD274(1), CD28(1), CD34(2), CD4(4), CD40(1), CD40LG(1), CD58(1), CD86(2), CD8A(2), CD99(2), CDH15(3), CDH2(1), CDH3(1), CDH4(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CNTN1(7), CNTN2(4), CNTNAP1(4), CNTNAP2(6), CTLA4(1), ESAM(2), F11R(2), GLG1(4), HLA-A(4), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(1), ICAM3(2), ICOS(1), ICOSLG(2), ITGA4(2), ITGA6(4), ITGA8(3), ITGA9(2), ITGAL(1), ITGAM(3), ITGAV(6), ITGB1(3), ITGB2(4), ITGB8(2), JAM3(1), L1CAM(4), MAG(2), MPZL1(1), NCAM1(4), NCAM2(3), NEGR1(1), NEO1(5), NFASC(6), NLGN1(2), NLGN2(3), NLGN3(5), NRCAM(3), NRXN1(6), NRXN2(10), NRXN3(7), PDCD1(1), PTPRC(3), PTPRF(6), PTPRM(3), PVRL1(2), PVRL2(2), PVRL3(4), SDC2(2), SELE(1), SELL(5), SELP(8), SIGLEC1(2), SPN(2), VCAM1(4), VCAN(12)	154401352	252	186	246	71	45	49	67	41	50	0	0.0724	1.000	1.000
410	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS1(3), CDS2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), OCRL(6), PI4KA(5), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3C3(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PRKCG(2), SYNJ1(2), SYNJ2(1)	134579316	202	175	197	64	35	34	55	41	37	0	0.453	1.000	1.000
411	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	138	APC(5), AXIN1(1), AXIN2(1), BTRC(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CCND1(1), CCND3(2), CER1(1), CHD8(3), CREBBP(7), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTNNB1(1), CUL1(2), DAAM1(3), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LRP5(1), LRP6(3), MAP3K7(1), MAPK10(2), MAPK8(2), MYC(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NKD1(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PORCN(1), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRICKLE1(2), PRICKLE2(3), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PSEN1(1), RHOA(2), ROCK1(4), ROCK2(4), RUVBL1(1), SFRP1(2), SFRP4(2), SIAH1(3), SMAD2(4), SMAD3(3), SMAD4(3), TBL1X(4), TCF7(3), TCF7L1(2), TCF7L2(3), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1)	170102242	218	175	217	70	47	37	63	42	29	0	0.344	1.000	1.000
412	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	ARAF(4), BRAF(3), C7orf16(2), CACNA1A(13), CRHR1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), GRIA1(8), GRIA2(3), GRIA3(10), GRID2(6), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IGF1(1), IGF1R(2), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(7), NOS3(3), NPR1(3), NPR2(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PRKCG(2), PRKG1(3), PRKG2(6), RAF1(1), RYR1(16)	122854274	206	175	205	58	42	46	58	35	25	0	0.0299	1.000	1.000
413	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	105	ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ARHGAP5(3), BCAR1(2), CD99(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), CYBB(1), ESAM(2), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), GRLF1(7), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), ITK(4), JAM3(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP9(1), MSN(2), MYL5(1), MYLPF(1), NCF1(3), NCF2(4), NCF4(1), NOX1(1), NOX3(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), PTK2B(3), PTPN11(1), RAPGEF3(2), RAPGEF4(3), RASSF5(2), RHOA(2), ROCK1(4), ROCK2(4), SIPA1(1), TXK(2), VAV1(4), VAV2(2), VAV3(4), VCAM1(4), VCL(4)	132798851	195	168	195	67	29	36	56	34	40	0	0.685	1.000	1.000
414	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	73	ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ACVR1B(6), ACVR1C(2), CREBBP(7), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), EGFR(5), EP300(7), FARP2(5), FER(1), IGF1R(2), INSR(4), IQGAP1(2), LMO7(2), MAP3K7(1), MAPK1(1), MAPK3(1), MET(7), MLLT4(12), NLK(2), PARD3(4), PTPRB(10), PTPRF(6), PTPRJ(3), PTPRM(3), PVRL1(2), PVRL2(2), PVRL3(4), PVRL4(2), RHOA(2), SMAD2(4), SMAD3(3), SMAD4(3), SNAI1(2), SNAI2(1), SORBS1(5), SSX2IP(1), TCF7(3), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(3), TJP1(6), VCL(4), WAS(3), WASF1(5), WASF3(1), WASL(1), YES1(2)	130711315	204	166	202	62	37	36	59	24	48	0	0.499	1.000	1.000
415	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	89	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), DRD2(2), EGF(3), EGFR(5), GJA1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), HTR2A(3), HTR2B(1), HTR2C(2), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(3), NPR2(2), NRAS(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKG1(3), PRKG2(6), PRKX(2), RAF1(1), SOS1(4), SOS2(4), TJP1(6), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1)	145234258	205	165	204	69	46	34	62	37	26	0	0.445	1.000	1.000
416	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(1), ACVR1B(6), ACVRL1(1), AURKB(1), BMPR2(3), BUB1(1), CDKL1(3), CDKL2(1), CDS1(3), CDS2(2), CLK1(2), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), MAP3K10(4), MOS(3), NEK1(1), NEK3(4), OCRL(6), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CB(6), PIK3CG(3), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3), PLK3(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKG1(3), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KB1(2), STK11(2), TGFBR1(2), VRK1(2)	123527377	190	164	187	56	35	26	55	36	38	0	0.320	1.000	1.000
417	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	147	ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CCRL1(1), CCRL2(2), CHML(4), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CMKLR1(2), CNR1(2), CNR2(1), CX3CR1(3), CXCR3(5), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR17(2), GPR174(3), GPR3(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(1), GPR83(4), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LHCGR(5), MAS1(2), MC3R(2), MC4R(2), NMBR(2), NMUR1(1), NMUR2(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(4), SSTR2(1), SSTR3(2)	120528259	199	163	200	75	52	25	52	45	25	0	0.471	1.000	1.000
418	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	91	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ATF4(2), CACNA1C(10), CACNA1D(7), CACNA1F(11), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH1(1), GNRH2(3), GRB2(1), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MMP14(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLD1(5), PLD2(2), PRKACA(2), PRKACG(1), PRKCD(2), PRKX(2), PTK2B(3), RAF1(1), SOS1(4), SOS2(4)	135930944	199	163	197	77	47	31	60	36	25	0	0.809	1.000	1.000
419	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), ATP1B1(2), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(2), NT5E(5), NT5M(1), NUDT2(1), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1)	141799104	200	162	199	68	37	30	71	31	31	0	0.695	1.000	1.000
420	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(6), ABCA10(7), ABCA12(5), ABCA13(16), ABCA2(1), ABCA3(6), ABCA4(7), ABCA5(6), ABCA6(4), ABCA7(7), ABCA8(10), ABCA9(5), ABCB1(4), ABCB10(5), ABCB11(7), ABCB4(2), ABCB5(4), ABCB6(3), ABCB7(5), ABCB8(5), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(3), ABCC12(6), ABCC2(5), ABCC3(4), ABCC4(4), ABCC5(4), ABCC6(4), ABCC8(7), ABCC9(10), ABCD1(4), ABCD2(2), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(2), CFTR(9), TAP1(2)	131376662	195	160	195	55	35	30	71	33	26	0	0.0928	1.000	1.000
421	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(10), ASH2L(3), CARM1(2), CTCFL(3), DOT1L(5), EED(3), EHMT1(6), EZH1(1), EZH2(1), FBXO11(2), HCFC1(11), JMJD6(1), KDM6A(10), MEN1(4), MLL(10), MLL2(13), MLL4(6), MLL5(7), NSD1(2), OGT(3), PAXIP1(5), PRDM2(3), PRDM6(2), PRDM7(2), PRDM9(2), PRMT1(1), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), RBBP5(2), SATB1(2), SETD1A(2), SETD1B(3), SETD2(11), SETD7(2), SETD8(1), SETDB1(9), SETDB2(1), SETMAR(1), SMYD3(3), SUV420H1(5), SUZ12(4), WHSC1(7), WHSC1L1(4)	124699313	184	158	182	32	27	26	53	30	47	1	0.0141	1.000	1.000
422	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	104	ABL1(5), ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), ATM(18), ATR(6), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(1), CDC20(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), CHEK2(3), CREBBP(7), CUL1(2), E2F1(4), E2F3(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(3), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTTG1(1), PTTG2(1), RBL1(3), RBL2(1), SKP2(1), SMAD2(4), SMAD3(3), SMAD4(3), SMC1A(5), SMC1B(4), TFDP1(2), TGFB1(2), TGFB3(1), WEE1(2), YWHAB(1), YWHAG(1), YWHAZ(1)	148533174	197	157	195	42	27	32	58	34	46	0	0.0429	1.000	1.000
423	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	74	ABL1(5), ACTN1(1), AKT2(3), AKT3(4), ANGPTL2(1), ARHGEF6(4), ARHGEF7(2), BCAR1(2), BRAF(3), CAV1(2), CRK(1), CSE1L(3), EPHB2(3), GRB2(1), GRB7(5), GRLF1(7), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(8), MYLK2(2), P4HB(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CB(6), PKLR(3), PLCG1(6), PLCG2(3), PTK2(5), RAF1(1), RHO(4), ROCK1(4), ROCK2(4), SHC1(1), SOS1(4), SOS2(4), TERF2IP(3), TLN1(12), TLN2(5), WAS(3)	130726130	188	157	188	61	37	34	47	34	36	0	0.451	1.000	1.000
424	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	91	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), AKAP1(3), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(7), AKAP6(7), AKAP7(1), AKAP8(2), AKAP9(14), ARHGEF1(7), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), IL18BP(1), ITPR1(10), KCNJ3(1), NRAS(1), PALM2(3), PDE1A(2), PDE1B(2), PDE1C(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE7B(1), PDE8A(1), PLCB3(3), PPP3CA(4), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKD3(3), RHOA(2), SLC9A1(1), USP5(4)	130470480	184	156	184	61	36	28	59	38	23	0	0.493	1.000	1.000
425	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), G6PC(1), G6PC2(2), GAA(2), GANC(2), GBA(1), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), IFIH1(3), MGAM(12), MOV10L1(4), NUDT5(1), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RAD54B(6), RAD54L(2), SETX(11), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(2), TREH(1), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), UXS1(2)	139066234	179	155	179	46	27	33	48	46	25	0	0.121	1.000	1.000
426	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(5), BDKRB1(2), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1S(2), C2(1), C3(7), C3AR1(2), C4BPA(4), C4BPB(2), C5(4), C5AR1(1), C6(5), C7(6), C9(1), CD46(2), CD55(2), CFB(1), CFH(12), CPB2(1), CR1(10), CR2(4), F13A1(4), F13B(3), F2(4), F2R(3), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(3), MASP2(2), MBL2(1), PLAT(3), PLAU(2), PLAUR(1), PLG(4), PROC(1), PROS1(1), SERPINA1(5), SERPINA5(3), SERPINC1(4), SERPIND1(1), SERPINE1(3), SERPINF2(1), SERPING1(2), TFPI(2), VWF(10)	100804240	179	152	177	49	20	30	68	30	31	0	0.231	1.000	1.000
427	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	97	ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(6), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(1), CREB3L2(2), CREB3L3(4), CREB3L4(2), CREBBP(7), CTNNB1(1), DCT(2), DVL1(2), DVL3(2), EDN1(2), EDNRB(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), KIT(5), KITLG(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), TCF7(3), TCF7L1(2), TCF7L2(3), TYR(6), TYRP1(4), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1)	114755322	180	152	179	60	48	35	54	27	16	0	0.316	1.000	1.000
428	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT3(4), BCAR1(2), CAPN1(4), CAPN10(1), CAPN11(1), CAPN2(3), CAPN3(2), CAPN6(2), CAPN7(1), CAV1(2), CRK(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK10(2), MAPK4(6), MAPK6(3), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PTK2(5), RAPGEF1(4), RHO(4), ROCK1(4), ROCK2(4), SDCCAG8(6), SEPP1(2), SHC1(1), SHC3(1), SORBS1(5), SOS1(4), TLN1(12), TNS1(7), VAV2(2), VAV3(4), VCL(4)	149289623	190	152	188	71	35	38	45	38	34	0	0.841	1.000	1.000
429	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(3), ADCY8(7), ARAF(4), ATF4(2), BRAF(3), CACNA1C(10), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CREBBP(7), EP300(7), GNAQ(1), GRIA1(8), GRIA2(3), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP1R12A(3), PPP1R1A(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), RAPGEF3(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3)	112928110	182	148	181	53	40	33	53	32	24	0	0.100	1.000	1.000
430	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(4), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(2), FCGR3A(1), FCGR3B(1), GRB2(1), HLA-A(4), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), ITGAL(1), ITGB2(4), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR3DL1(1), KIR3DL2(5), KLRC1(3), KLRC3(1), KLRK1(1), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(3), NCR2(3), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NRAS(1), PAK1(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP2(1), ULBP3(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2)	118376500	177	145	176	54	24	44	54	25	30	0	0.298	1.000	1.000
431	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	88	AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(4), CBLB(10), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD4(4), CD40LG(1), CD8A(2), CDK4(1), CHUK(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(4), IL2(1), ITK(4), JUN(3), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCQ(6), PTPRC(3), RHOA(2), SOS1(4), SOS2(4), TEC(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2)	104711986	169	144	169	54	23	42	51	28	24	1	0.462	1.000	1.000
432	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	78	ABL1(5), ABL2(4), AKT2(3), AKT3(4), ARAF(4), AREG(1), BRAF(3), BTC(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CBL(4), CBLB(10), CBLC(2), CRK(1), CRKL(1), EGF(3), EGFR(5), ELK1(2), ERBB3(11), ERBB4(6), GAB1(2), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRAS(1), NRG1(2), NRG3(4), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), RAF1(1), RPS6KB1(2), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), STAT5A(4), STAT5B(5), TGFA(1)	102812029	173	143	173	47	29	35	50	33	26	0	0.146	1.000	1.000
433	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	79	ABL1(5), ATM(18), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(2), CDC14A(2), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDK2(1), CDK4(1), CHEK2(3), DTX4(2), E2F1(4), E2F3(1), E2F4(4), E2F5(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(3), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), HDAC8(4), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MPEG1(2), MPL(1), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTPRA(2), PTTG1(1), PTTG2(1), RBL1(3), SKP2(1), SMAD4(3), TBC1D8(4), TFDP1(2), TGFB1(2), WEE1(2)	120779703	175	142	171	41	21	31	51	27	45	0	0.0935	1.000	1.000
434	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	85	ACVR1(1), ACVR1B(6), ACVR1C(2), ACVR2A(4), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(3), BMPR2(3), CHRD(3), COMP(5), CREBBP(7), CUL1(2), E2F4(4), E2F5(1), EP300(7), FST(2), GDF6(2), ID2(1), IFNG(2), INHBA(3), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), RBL1(3), RBL2(1), RHOA(2), ROCK1(4), ROCK2(4), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(4), SMAD3(3), SMAD4(3), SMAD5(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(3), TFDP1(2), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(3), THBS4(2), ZFYVE16(3), ZFYVE9(3)	108146897	161	139	156	40	29	25	38	31	38	0	0.134	1.000	1.000
435	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	105	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG6(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(2), CHST2(3), CHST3(1), CHSY1(1), DPAGT1(2), EXT1(5), EXT2(6), EXTL3(4), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GANAB(3), GCNT4(2), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST2(5), HS6ST3(1), MAN1A1(1), MAN1A2(2), MAN1B1(4), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST3(2), OGT(3), RPN1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(3), STT3B(2), UST(3), WBSCR17(5), XYLT1(2), XYLT2(1)	118284641	169	138	169	64	31	31	38	35	34	0	0.803	1.000	1.000
436	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(6), CD14(2), CD19(3), CD1A(1), CD1B(4), CD1C(3), CD1D(3), CD1E(3), CD2(3), CD22(1), CD33(1), CD34(2), CD36(1), CD37(1), CD38(3), CD3E(2), CD3G(2), CD4(4), CD44(2), CD5(2), CD55(2), CD8A(2), CD9(2), CR1(10), CR2(4), CSF1(3), CSF2RA(2), CSF3R(3), DNTT(4), EPOR(4), FCGR1A(1), FLT3(3), FLT3LG(1), IL11(1), IL11RA(4), IL1A(1), IL1R1(1), IL1R2(5), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL7R(4), IL9R(1), ITGA1(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGAM(3), ITGB3(3), KIT(5), KITLG(3), MS4A1(1), TFRC(1), TPO(5)	91414405	157	129	157	40	25	31	45	31	25	0	0.0539	1.000	1.000
437	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	89	CD2BP2(1), CDC40(2), CLK3(1), CLK4(1), COL2A1(5), CPSF1(4), CPSF3(3), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(4), DDX20(2), DHX15(2), DHX16(1), DHX38(2), DHX8(2), DHX9(2), DICER1(5), FUS(2), GIPC1(1), METTL3(2), NCBP1(1), NONO(2), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(2), POLR2A(5), PRPF3(2), PRPF4(4), PRPF4B(6), PRPF8(7), PSKH1(2), PTBP1(3), RBM17(1), RBM5(3), RNGTT(1), SF3A1(1), SF3B2(3), SF3B4(2), SF4(6), SFRS12(1), SFRS14(2), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS7(1), SFRS8(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(7), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4)	114457642	142	124	142	27	23	34	43	23	18	1	0.0128	1.000	1.000
438	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	88	ACTB(2), CABIN1(5), CAMK4(3), CD3E(2), CD3G(2), CD69(2), CNR1(2), CREBBP(7), CSNK2A1(1), CTLA4(1), EGR2(2), EGR3(2), EP300(7), FCER1A(4), FCGR3A(1), GRLF1(7), GSK3A(3), ICOS(1), IFNA1(1), IFNB1(1), IFNG(2), IL2(1), IL6(2), ITK(4), KPNA5(2), MAP2K7(1), MAPK14(2), MAPK8(2), MEF2B(1), MEF2D(2), MYF5(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), PAK1(2), PPP3CB(3), PPP3R1(1), PTPRC(3), RELA(1), RPL13A(3), SP1(3), SP3(4), TGFB1(2), TRPV6(2), VAV1(4), VAV2(2), VAV3(4), XPO5(4)	97296281	143	121	142	45	17	31	40	20	34	1	0.490	1.000	1.000
439	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	92	AKT2(3), AKT3(4), CD14(2), CD40(1), CD86(2), CHUK(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(4), IKBKE(2), IL12A(1), IL12B(1), IL6(2), IRAK1(2), IRAK4(3), IRF3(3), IRF5(1), IRF7(1), JUN(3), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(5), TIRAP(1), TLR1(1), TLR2(1), TLR3(5), TLR5(2), TLR7(8), TLR8(3), TLR9(1), TRAF3(2), TRAF6(3)	87954480	135	119	132	36	16	33	31	21	32	2	0.111	1.000	1.000
440	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	79	ATF2(2), BRAF(3), CHUK(1), CREB1(1), DAXX(2), ELK1(2), GRB2(1), IKBKB(4), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP3K9(4), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(3), MAPK8(2), MAPKAPK2(1), MAPKAPK3(1), MAX(3), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), NFKB1(4), NFKBIA(1), PAK1(2), PAK2(2), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(4), SHC1(1), SP1(3), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2)	97646957	139	119	138	35	30	28	36	16	29	0	0.0705	1.000	1.000
441	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPPL1(4), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), MINPP1(1), OCRL(6), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), SYNJ1(2), SYNJ2(1)	77989547	128	117	125	32	22	18	38	22	28	0	0.147	1.000	1.000
442	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	66	ACACB(9), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), AKT2(3), AKT3(4), CAMKK1(3), CAMKK2(2), CD36(1), CHUK(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), G6PC(1), G6PC2(2), IKBKB(4), IRS1(2), IRS4(6), JAK1(4), JAK2(5), JAK3(5), LEPR(4), MAPK10(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(2), PCK2(3), PPARA(2), PPARGC1A(5), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(3), PRKCQ(6), PTPN11(1), RELA(1), RXRA(1), RXRG(1), SLC2A4(1), STAT3(3), STK11(2), TNFRSF1A(1), TYK2(5)	87319205	135	114	135	34	24	25	34	21	30	1	0.0894	1.000	1.000
443	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	75	AIFM1(1), AKT2(3), AKT3(4), APAF1(3), ATM(18), BAX(2), BID(4), BIRC3(1), CAPN1(4), CAPN2(3), CASP6(2), CASP7(1), CASP9(1), CHUK(1), CSF2RB(3), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL3RA(2), IRAK1(2), IRAK2(3), IRAK3(1), IRAK4(3), NFKB1(4), NFKB2(3), NFKBIA(1), NTRK1(4), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1)	84917738	130	112	129	28	16	32	30	21	30	1	0.0341	1.000	1.000
444	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	84	CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), NME4(1), NME6(1), NME7(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), RRM1(2), RRM2(1), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3), UPRT(2)	90696126	118	106	118	41	20	20	35	21	22	0	0.658	1.000	1.000
445	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	60	ATM(18), CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(2), CREB3(1), CREB3L1(1), CREB3L3(4), CREB3L4(2), E2F1(4), E2F3(1), E2F4(4), E2F5(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MNAT1(2), MYC(1), MYT1(5), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLE(7), POLE2(1), RBL1(3), RPA1(1), RPA2(1), RPA3(2), TFDP1(2), TFDP2(4), TNXB(7), WEE1(2)	79028860	115	104	112	24	15	21	34	19	26	0	0.0556	1.000	1.000
446	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	58	AKT2(3), AKT3(4), CDK2(1), CREB1(1), CREB3(1), CREB5(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(2), GRB2(1), GSK3A(3), IFI27(2), IGF1(1), INPPL1(4), IRS1(2), IRS4(6), MET(7), MYC(1), NOLC1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARD3(4), PDK1(1), PIK3CD(4), PPP1R13B(3), PREX1(10), PTK2(5), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAG(1), YWHAZ(1)	77477469	118	103	117	34	23	23	38	16	18	0	0.317	1.000	1.000
447	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	69	AKT2(3), AKT3(4), BTK(4), FCER1A(4), GAB2(2), GRB2(1), INPP5D(4), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NRAS(1), PDK1(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PRKCD(2), PRKCE(2), RAF1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4), VAV2(2), VAV3(4)	72502816	109	102	109	30	18	26	29	20	16	0	0.112	1.000	1.000
448	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CHPT1(3), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(3), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(4), MYST4(8), PCYT1A(2), PCYT1B(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PNPLA3(2), PPAP2A(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(1)	72332366	111	100	109	37	22	17	30	28	13	1	0.543	1.000	1.000
449	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	58	AKT2(3), AKT3(4), BCL10(1), BLNK(1), BTK(4), CARD11(4), CD19(3), CD22(1), CD72(1), CD79A(1), CD79B(1), CHUK(1), CR2(4), IFITM1(1), IKBKB(4), INPP5D(4), JUN(3), LYN(4), MALT1(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), RASGRP3(1), SYK(2), VAV1(4), VAV2(2), VAV3(4)	75141392	112	98	112	37	13	27	35	16	20	1	0.572	1.000	1.000
450	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	43	AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), CD22(1), CR2(4), DAG1(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPP5D(4), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), MAP4K1(4), MAPK1(1), MAPK3(1), NFATC2(2), NR0B2(2), PDK1(1), PIK3CD(4), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(3), PTPRC(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4)	75503807	109	98	109	32	18	25	32	21	13	0	0.188	1.000	1.000
451	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT2(3), AKT3(4), ASAH1(1), BRAF(3), DAG1(1), DRD2(2), EGFR(5), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PI3(1), PIK3CB(6), PITX2(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(4), STAT3(3), TERF2IP(3)	64306320	101	94	101	26	16	22	25	22	16	0	0.0882	1.000	1.000
452	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	65	AKT2(3), AKT3(4), CASP9(1), KDR(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NOS3(3), NRAS(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCG(2), PTGS2(2), PTK2(5), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(2)	71236847	101	91	101	38	13	27	31	15	15	0	0.636	1.000	1.000
453	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(1), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CHUK(1), EGFR(5), F11R(2), GIT1(1), IGSF5(2), IKBKB(4), JAM3(1), JUN(3), LYN(4), MAPK10(2), MAPK13(1), MAPK14(2), MAPK8(2), MET(7), NFKB1(4), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(6), PLCG2(3), PTPN11(1), PTPRZ1(8), RELA(1), TCIRG1(1), TJP1(6)	78286253	98	91	98	25	14	19	32	11	21	1	0.205	1.000	1.000
454	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	40	AKT2(3), AKT3(4), ANGPTL2(1), ARHGAP4(1), ARHGEF11(3), BTK(4), GDI1(4), INPPL1(4), ITPR1(10), ITPR2(7), ITPR3(6), LIMK1(4), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDK1(1), PIK3CD(4), PIK3CG(3), PITX2(3), PPP1R13B(3), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), SAG(1), WASF1(5), WASL(1)	72185532	106	91	106	35	18	21	30	20	17	0	0.442	1.000	1.000
455	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(7), DLL1(2), DLL4(1), DTX1(4), DTX2(4), DTX3(1), DTX4(2), DVL1(2), DVL3(2), EP300(7), HDAC1(4), HDAC2(3), JAG1(3), MAML1(2), MAML2(4), MAML3(5), NCSTN(2), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(7), NUMB(2), NUMBL(5), PSEN1(1), PSEN2(3), PSENEN(1), PTCRA(1), RBPJL(5), RFNG(2), SNW1(2)	65438803	100	89	97	27	20	18	25	12	25	0	0.169	1.000	1.000
456	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	65	ATP8A1(2), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CX3CR1(3), CXCR3(5), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR77(1), GRPR(1), LHCGR(5), MC2R(2), MC3R(2), MC4R(2), NMBR(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR1(1), TACR2(2), TACR3(1), TSHR(4)	56107893	98	89	98	33	22	15	27	23	11	0	0.253	1.000	1.000
457	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(3), CPEB1(4), EGFR(5), ERBB4(6), ETS1(3), ETS2(5), ETV6(2), ETV7(2), FMN2(12), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(7), PIWIL1(8), PIWIL2(4), PIWIL3(5), PIWIL4(2), RAF1(1), SOS1(4), SOS2(4), SPIRE1(1), SPIRE2(1)	50606262	99	87	97	28	12	25	26	16	20	0	0.288	1.000	1.000
458	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(1), ADCY4(2), ADCY6(1), ADCY8(7), CACNA1A(13), CACNA1B(9), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(6), KCNB1(4), PDE1A(2), PLCB2(2), PRKACA(2), PRKACG(1), PRKX(2), SCNN1B(2), SCNN1G(1), TAS1R1(1), TAS1R2(1), TAS1R3(1), TAS2R1(1), TAS2R10(3), TAS2R13(2), TAS2R14(2), TAS2R16(3), TAS2R3(1), TAS2R38(1), TAS2R40(1), TAS2R42(1), TAS2R43(2), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(4)	62556795	95	87	96	32	23	17	26	17	12	0	0.249	1.000	1.000
459	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	91	ANK2(7), B3GALT4(2), CDR1(1), DGKI(7), IL6ST(6), RPL10(2), RPL13A(3), RPL14(1), RPL17(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(3), RPL7(1), RPL8(1), RPLP0(1), RPLP2(1), RPS10(1), RPS14(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS4X(2), RPS5(4), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), RPSA(1), SLC36A2(2), TBC1D10C(2), UBA52(1)	57466676	93	86	92	23	17	13	34	16	13	0	0.383	1.000	1.000
460	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), ENPP1(5), ENPP3(2), G6PC(1), GAA(2), GANAB(3), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), MGAM(12), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RNPC3(1), SI(9), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2), UXS1(2)	65078794	93	85	93	29	14	17	22	25	15	0	0.466	1.000	1.000
461	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	54	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), CARM1(2), DBH(3), DCT(2), DDC(1), ESCO1(3), FAH(1), GSTZ1(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(4), MYST4(8), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(5), TYR(6), TYRP1(4), WBSCR22(2)	64825432	96	84	96	27	18	23	29	11	14	1	0.231	1.000	1.000
462	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	54	BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(2), DHH(1), GLI1(3), GLI2(5), GLI3(8), LRP2(24), PRKACA(2), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(1), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1)	62492805	95	84	95	26	32	9	22	20	12	0	0.182	1.000	1.000
463	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	52	ALG2(2), BAK1(2), BAX(2), BFAR(2), BTK(4), CAD(10), CSNK1A1(1), DAXX(2), EGFR(5), EPHB2(3), IL1A(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MET(7), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(5), RALBP1(1), RIPK1(3), ROCK1(4), SMPD1(1), TUFM(2)	69526682	89	80	88	21	13	22	24	11	18	1	0.119	1.000	1.000
464	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(4), CD28(1), CTLA4(1), DAG1(1), EPHB2(3), FBXW7(6), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(7), LAT(1), LCK(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLCG1(6), PTPRC(3), RAF1(1), RASGRP2(2), RASGRP3(1), RASGRP4(1), SOS1(4), SOS2(4), VAV1(4), ZAP70(2)	61246445	88	80	88	29	17	20	21	17	12	1	0.531	1.000	1.000
465	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	64	ACOX1(2), ACOX2(1), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), APOA5(1), CD36(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP27A1(2), CYP4A11(1), CYP4A22(1), CYP7A1(1), CYP8B1(3), EHHADH(3), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK(1), GK2(3), HMGCS2(1), ILK(2), LPL(1), PCK1(2), PCK2(3), PLTP(1), PPARA(2), PPARG(2), RXRA(1), RXRG(1), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(5), SLC27A5(3), SORBS1(5), UCP1(1)	69471832	86	79	86	32	15	20	21	18	12	0	0.672	1.000	1.000
466	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CLC(1), CPT1B(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), ETNK1(3), GNPAT(3), GPD1(2), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(3), PCYT1A(2), PCYT1B(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(6), PLCG2(3), PPAP2A(1), PPAP2C(2)	54557613	84	78	82	28	15	12	23	21	13	0	0.540	1.000	1.000
467	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ACAT1(2), AFMID(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CARM1(2), CAT(1), CYP1A2(3), CYP1B1(1), DDC(1), EHHADH(3), GCDH(1), HAAO(1), HADH(2), HEMK1(1), HSD17B10(1), HSD17B4(6), INMT(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(4), MAOA(2), MAOB(1), METTL2B(2), NFX1(2), OGDH(4), OGDHL(4), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), TDO2(1), TPH2(2), WARS2(1), WBSCR22(2)	67826383	88	78	87	31	12	24	34	10	8	0	0.548	1.000	1.000
468	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C1(3), AKR1C2(4), AKR1C3(1), AKR1C4(2), ALDH1A3(3), ALDH3B2(2), CYP1A2(3), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	63570817	87	77	86	29	14	19	31	13	10	0	0.489	1.000	1.000
469	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(5), ATP4B(4), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(2), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFB3(1), NDUFB4(1), NDUFB5(3), NDUFB9(2), NDUFS2(2), NDUFS3(1), NDUFS5(1), NDUFS7(1), NDUFS8(1), NDUFV1(3), NDUFV2(1), NDUFV3(1), PPA1(2), PPA2(1), SDHB(1), TCIRG1(1), UQCRC1(3), UQCRC2(1)	63095295	84	76	85	21	15	9	29	16	15	0	0.203	1.000	1.000
470	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3L1(1), CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), NT5E(5), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), RRM1(2), RRM2(1), TXNRD1(2), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3)	63346775	83	76	83	28	10	16	26	11	20	0	0.604	1.000	1.000
471	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(5), AXIN1(1), CCND1(1), CCND3(2), CSNK1E(2), CTNNB1(1), DVL1(2), DVL3(2), FBXW2(2), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LDLR(1), MAPK10(2), MYC(1), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(2), TCF7(3), WNT10B(1), WNT11(2), WNT2(1), WNT2B(2), WNT4(1), WNT5B(2), WNT7A(5)	61995744	84	76	84	29	22	14	20	19	9	0	0.373	1.000	1.000
472	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	44	AKT2(3), AKT3(4), BRD4(2), CAP1(2), CBL(4), F2RL2(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPPL1(4), IRS1(2), IRS4(6), MAPK1(1), MAPK3(1), PARD3(4), PDK1(1), PIK3CD(4), PPYR1(1), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SERPINB6(1), SHC1(1), SLC2A4(1), SORBS1(5), SOS1(4), SOS2(4), YWHAB(1), YWHAG(1), YWHAZ(1)	56512488	79	75	79	29	19	13	27	10	10	0	0.713	1.000	1.000
473	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	APC(5), AR(4), ASAH1(1), BRAF(3), CCL13(2), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(9), PIK3CD(4), PITX2(3), PTX3(1), RAF1(1)	54143285	79	75	79	26	9	15	21	21	13	0	0.520	1.000	1.000
474	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(4), NUDT5(1), RAD54B(6), RAD54L(2), SETX(11), SKIV2L2(2), SMARCA2(5), SMARCA5(2)	69121848	85	74	84	18	15	15	27	18	10	0	0.0783	1.000	1.000
475	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	27	ACTA1(2), BDKRB2(1), CAV1(2), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(3), PDE2A(4), PDE3A(8), PDE3B(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKG1(3), PRKG2(6), RYR2(32)	44787850	78	73	78	42	10	12	32	15	9	0	0.993	1.000	1.000
476	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT2(3), AKT3(4), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), STK11(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(2)	51874870	76	72	76	21	12	20	18	14	12	0	0.274	1.000	1.000
477	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), BCR(3), CAPN1(4), CAV1(2), CRKL(1), GRB2(1), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(1), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), SOS1(4), TLN1(12), VCL(4)	51971535	75	72	75	26	14	15	19	13	14	0	0.654	1.000	1.000
478	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AGPAT1(1), AGPAT3(2), AGPAT4(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DGAT1(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), GK(1), GLA(4), GLB1(2), LCT(11), LIPC(1), LIPF(2), LIPG(1), LPL(1), PNLIP(3), PNLIPRP1(3), PPAP2A(1), PPAP2C(2)	53452826	77	71	75	23	18	14	19	14	12	0	0.256	1.000	1.000
479	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), HADH(2), HSD17B10(1), HSD17B4(6), NSD1(2), OGDH(4), OGDHL(4), PIPOX(1), PLOD1(2), PLOD2(2), PLOD3(3), RDH11(2), RDH12(1), RDH14(2), SETD1A(2), SETD7(2), SETDB1(9), SHMT2(1)	61870776	77	71	76	25	11	20	28	10	8	0	0.394	1.000	1.000
480	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F13B(3), F2(4), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), LPA(11), PLAT(3), PLAU(2), PLG(4), SERPINE1(3), SERPINF2(1), VWF(10)	39139070	74	70	72	22	7	9	33	13	12	0	0.453	1.000	1.000
481	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	44	ACOX1(2), CD36(1), CITED2(2), CPT1B(2), CREBBP(7), EHHADH(3), EP300(7), FABP1(1), HSD17B4(6), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(2), NFKBIA(1), NR0B2(2), NR2F1(1), NRIP1(3), PPARA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTGS2(2), RELA(1), RXRA(1), SP1(3), SRA1(1), STAT5A(4), STAT5B(5)	52943429	74	70	73	21	14	13	20	11	16	0	0.287	1.000	1.000
482	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	ACTA1(2), AGT(2), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(7), CSNK1A1(1), EDN1(2), ELSPBP1(2), F2(4), HAND2(1), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(3), NFATC2(2), NFATC3(4), NFATC4(5), NPPA(1), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KB1(2)	50210308	74	69	74	28	6	12	30	14	12	0	0.799	1.000	1.000
483	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	33	ACTG1(4), ACTG2(2), ANGPTL2(1), FLNA(5), FLNC(10), FSCN3(1), GDI1(4), LIMK1(4), MYH2(3), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), WASF1(5), WASL(1)	49831078	74	68	74	29	14	16	24	8	12	0	0.792	1.000	1.000
484	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1)	53297145	69	66	69	26	10	11	24	10	14	0	0.744	1.000	1.000
485	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	48	ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1)	53297145	69	66	69	26	10	11	24	10	14	0	0.744	1.000	1.000
486	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	38	ALK(3), AR(4), ESR1(3), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1I2(1), NR1I3(1), NR2C2(2), NR2E1(2), NR2F1(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A2(5), PGR(4), PPARA(2), PPARG(2), RARA(2), RARB(5), RARG(3), ROR1(8), RORA(1), RORC(3), RXRA(1), RXRG(1), THRA(1), THRB(1)	43183934	68	66	68	27	13	15	15	9	16	0	0.720	1.000	1.000
487	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACYP1(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), G6PC2(2), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGAM4(1), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2)	64247562	67	64	67	15	12	20	17	12	6	0	0.0184	1.000	1.000
488	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	ANGPTL2(1), DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(8), PDE3B(2), PI3(1), PIK3C2G(3), PIK3CD(4), PLDN(1), RIPK3(2), RPS4X(2), SGCB(1)	49658724	68	64	68	24	8	16	18	17	9	0	0.597	1.000	1.000
489	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADSB(2), ACADVL(3), ACAT1(2), ACOX1(2), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP4A11(1), CYP4A22(1), EHHADH(3), GCDH(1), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PECI(1)	55157495	66	63	66	18	10	18	21	11	6	0	0.211	1.000	1.000
490	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	52	AKR1C4(2), AKR1D1(1), ARSE(2), CARM1(2), CYP11B1(2), CYP11B2(5), HEMK1(1), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), WBSCR22(2)	54068528	70	63	70	27	14	15	26	9	6	0	0.702	1.000	1.000
491	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CDK5(1), F2(4), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(3), MYLK(8), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4)	46881867	64	61	64	23	10	12	18	11	13	0	0.644	1.000	1.000
492	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PIPOX(1), RDH11(2), RDH12(1), RDH14(2), SARDH(2), SARS(3), SARS2(2), SHMT2(1), TARS(5), TARS2(6)	47666235	67	61	67	20	7	15	16	16	13	0	0.332	1.000	1.000
493	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	40	CHUK(1), DAXX(2), EGF(3), EGFR(5), ETS1(3), ETS2(5), IKBKB(4), JUN(3), MAP2K1(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKBIA(1), PPP2CA(2), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), RAF1(1), RELA(1), RIPK1(3), SP1(3), TNFRSF1A(1)	49944281	69	61	69	24	10	19	12	15	13	0	0.444	1.000	1.000
494	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(2), CAPN1(4), CAPN2(3), CXCR3(5), EGF(3), EGFR(5), ITGA1(5), ITGB1(3), MAPK1(1), MAPK3(1), MYLK(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTK2(5), TLN1(12)	37365417	64	61	64	24	11	14	20	12	7	0	0.710	1.000	1.000
495	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PLCB2(2), PLCG1(6), PLCG2(3), SARDH(2), SARS(3), SHMT2(1), TARS(5)	46734941	66	60	66	22	8	12	16	16	14	0	0.559	1.000	1.000
496	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG5(1), ALG6(1), ALG8(1), ALG9(2), B4GALT1(2), B4GALT3(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(2), GANAB(3), MAN1A1(1), MAN1A2(2), MAN1B1(4), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RPN1(2), STT3B(2)	46412345	65	60	65	16	7	16	17	11	14	0	0.191	1.000	1.000
497	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(1), ARHGAP5(3), ARHGAP6(2), ARHGEF1(7), ARHGEF11(3), ARHGEF5(2), ARPC1A(1), ARPC1B(2), ARPC2(2), DIAPH1(4), GSN(1), LIMK1(4), MYLK(8), OPHN1(4), PIP5K1A(2), PIP5K1B(1), PPP1R12B(1), ROCK1(4), TLN1(12), VCL(4)	51386817	68	60	67	29	10	14	17	11	16	0	0.908	1.000	1.000
498	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	21	APC(5), ASAH1(1), DAG1(1), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PITX2(3), PTX3(1), RHO(4), RYR1(16)	50022809	63	60	63	25	11	17	12	15	8	0	0.588	1.000	1.000
499	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CAT(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), DDC(1), EHHADH(3), GCDH(1), HAAO(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), TDO2(1), WARS2(1)	62063169	71	60	70	33	7	15	26	14	9	0	0.941	1.000	1.000
500	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(3), ACAA2(2), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), AUH(1), BCAT1(4), BCAT2(3), BCKDHA(1), DLD(1), EHHADH(3), HADH(2), HADHB(2), HIBADH(1), HIBCH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), IVD(1), MCCC1(4), MUT(3), OXCT1(1), OXCT2(1), PCCA(1), PCCB(2)	48932258	60	57	60	16	5	17	17	14	7	0	0.294	1.000	1.000
501	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX15(2), ALOX15B(2), ALOX5(1), CBR1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP4A11(1), CYP4A22(1), CYP4F2(2), DHRS4(1), GGT1(3), GPX2(1), GPX4(1), GPX5(2), GPX7(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1)	43269832	59	57	58	19	11	9	23	8	8	0	0.397	1.000	1.000
502	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	38	CD3E(2), CD3G(2), ELK1(2), GRB2(1), JUN(3), LAT(1), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(4), ZAP70(2)	44100541	62	57	62	21	12	16	16	8	10	0	0.458	1.000	1.000
503	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(1), BTK(4), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAPK14(2), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4)	38504266	59	56	59	19	9	15	16	10	9	0	0.414	1.000	1.000
504	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	AGMAT(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), GAMT(1), GATM(4), MAOA(2), MAOB(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), P4HB(1), RARS(3)	48523766	62	55	62	19	10	14	26	8	4	0	0.313	1.000	1.000
505	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(3), NCF2(4), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PAK1(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(3), RAF1(1), RELA(1)	39346057	57	55	57	20	10	15	17	9	6	0	0.587	1.000	1.000
506	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	58	A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GBGT1(1), GCNT2(1), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1)	52110992	60	55	59	23	12	14	17	6	11	0	0.621	1.000	1.000
507	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	ACTA1(2), CRK(1), CRKL(1), ELK1(2), GAB1(2), GRB2(1), HGF(4), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAP4K1(4), MAPK1(1), MAPK3(1), MAPK8(2), MET(7), PAK1(2), PTK2(5), PTK2B(3), PTPN11(1), RAF1(1), RASA1(2), SOS1(4), STAT3(3)	45928836	62	55	62	19	13	17	15	8	9	0	0.338	1.000	1.000
508	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	41	CDC6(3), CDC7(1), CDK2(1), DIAPH2(4), MCM10(3), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), RFC1(4), RFC2(1), RFC4(3), RPA1(1), RPA2(1), RPA3(2), UBA52(1)	55212496	58	54	58	18	8	11	18	13	8	0	0.544	1.000	1.000
509	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1B2(1), EEF1D(1), EEF2(4), EEF2K(4), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF4A2(6), EIF4G1(2), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(2), KIAA0664(2), PABPC1(3), PABPC3(8), SLC35A4(1)	49226752	60	54	56	18	10	12	16	6	16	0	0.595	1.000	1.000
510	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), G6PC(1), GAA(2), GALK2(1), GALT(1), GANAB(3), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKM(4), PFKP(2), PGM1(1), PGM3(1)	35865078	56	53	56	17	11	10	11	16	8	0	0.269	1.000	1.000
511	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(3), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(4)	36969691	55	53	55	20	9	10	14	10	12	0	0.716	1.000	1.000
512	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(3), ABAT(3), ACAT1(2), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), BDH1(1), EHHADH(3), GAD1(2), GAD2(3), HADH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), ILVBL(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), PPME1(1), RDH11(2), RDH12(1), RDH14(2)	45639536	55	53	55	19	2	17	17	14	5	0	0.587	1.000	1.000
513	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP4B(4), ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(7), ATP7B(2), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1), PPA2(1), SDHB(1), UQCRC1(3)	43706867	55	50	55	19	13	6	16	10	10	0	0.684	1.000	1.000
514	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	29	AKT2(3), AKT3(4), ANKRD6(4), APC(5), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(2), DKK2(1), DKK3(2), DKK4(1), DVL1(2), GSK3A(3), LRP1(11), MVP(1), NKD1(1), NKD2(1), PSEN1(1), PTPRA(2), SFRP1(2), WIF1(2)	43287565	53	50	53	20	11	14	13	7	8	0	0.588	1.000	1.000
515	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), CAPN1(4), ITGA1(5), ITGB1(3), ITGB3(3), PTK2(5), SPTAN1(4), TLN1(12)	32339637	49	49	49	15	11	9	13	11	5	0	0.507	1.000	1.000
516	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(3), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(2), PTPRR(2), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(4), STAT3(3)	36412137	49	48	49	17	11	14	10	9	5	0	0.504	1.000	1.000
517	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(3), DIAPH1(4), GSN(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(8), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), TLN1(12)	38436182	50	47	49	17	6	12	15	9	8	0	0.668	1.000	1.000
518	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS2(4), BLVRB(1), COX10(3), COX15(1), CP(3), EARS2(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	46673959	49	47	49	24	7	10	16	10	6	0	0.967	1.000	1.000
519	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	34	ATF2(2), CREB1(1), DAXX(2), ELK1(2), GRB2(1), MAP2K6(1), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK14(2), MAPKAPK2(1), MAX(3), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(4), SHC1(1), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2)	35927996	50	47	50	17	6	11	19	6	8	0	0.651	1.000	1.000
520	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	25	ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), ESCO1(3), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1), TAT(2), TPO(5)	37191744	52	46	52	16	13	7	13	10	8	1	0.411	1.000	1.000
521	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GCNT4(2), OGT(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(5)	36533178	53	46	53	25	9	7	14	11	12	0	0.946	1.000	1.000
522	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), ARRB2(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(5), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDC(1), PDE1C(2), PRKACA(2), PRKACG(1), PRKG1(3), PRKG2(6), PRKX(2)	34582616	46	45	46	22	6	9	13	14	4	0	0.930	1.000	1.000
523	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	31	ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), DBH(3), DCT(2), DDC(1), FAH(1), GSTZ1(1), HGD(1), HPD(2), MAOA(2), MAOB(1), TAT(2), TH(1), TPO(5), TYR(6)	34172816	48	45	48	15	11	9	15	5	8	0	0.463	1.000	1.000
524	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(5), POLB(1), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLG(4), POLH(2), POLI(3), POLL(1), POLM(1), POLQ(8), REV1(2), REV3L(8)	45787032	47	44	47	12	3	9	15	9	11	0	0.458	1.000	1.000
525	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(1), APC(5), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(3), CHRD(3), CTNNB1(1), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(3), NPPA(1), RFC1(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2)	39579606	45	43	44	21	7	10	10	12	6	0	0.894	1.000	1.000
526	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), FUK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(1), PFKFB3(1), PFKL(1), PFKM(4), PFKP(2), PGM2(1), RDH11(2), RDH12(1), RDH14(2), SORD(2), TPI1(2), TSTA3(1)	41210738	45	43	45	13	8	11	9	9	8	0	0.143	1.000	1.000
527	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(2), ERCC3(2), GTF2E2(1), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(6), POLR1B(2), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3B(2), POLR3D(1), POLR3E(2), TAF13(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1), TBP(1)	38821072	45	43	45	22	7	8	13	6	11	0	0.932	1.000	1.000
528	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(1), EGF(3), EGFR(5), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4)	33911573	46	41	46	16	10	7	10	8	11	0	0.621	1.000	1.000
529	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	30	CBL(4), CRKL(1), E2F1(4), GRB2(1), IL2RB(1), IL2RG(1), IRS1(2), JAK1(4), JAK3(5), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2)	33462839	45	41	45	19	8	8	12	8	9	0	0.814	1.000	1.000
530	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	30	ADRA1A(2), ADRA1B(1), ADRB2(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), DRD2(2), DRD3(1), DRD5(2), HRH1(2), HRH2(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5)	27141231	43	41	43	19	16	3	11	6	7	0	0.766	1.000	1.000
531	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	CDK5(1), CHN1(3), LIMK1(4), MYLK(8), NCF2(4), PAK1(2), PDGFRA(3), PLD1(5), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(5), VAV1(4), WASF1(5)	32404598	48	41	48	19	5	14	16	9	4	0	0.745	1.000	1.000
532	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	22	GH1(1), GHR(2), GRB2(1), INSR(4), IRS1(2), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(6), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(4), STAT5B(5)	31946996	43	40	43	15	10	8	10	5	10	0	0.474	1.000	1.000
533	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(1), AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), PLOD1(2), PLOD2(2), PLOD3(3), SHMT2(1)	38376925	43	40	43	18	7	11	16	5	4	0	0.753	1.000	1.000
534	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(5), AXIN1(1), CREBBP(7), CTNNB1(1), DVL1(2), EP300(7), FZD1(1), HDAC1(4), LDB1(1), PITX2(3), TRRAP(9)	36445341	41	40	40	13	7	6	7	11	10	0	0.550	1.000	1.000
535	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	30	AGT(2), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), MEF2B(1), MEF2C(3), MEF2D(2), PAK1(2), PTK2(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	33194831	44	39	44	18	9	8	15	6	6	0	0.713	1.000	1.000
536	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	23	ARHGDIB(1), CASP6(2), CASP7(1), DAXX(2), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), PTPN13(5), SPTAN1(4)	41051955	39	39	39	10	6	9	10	5	9	0	0.374	1.000	1.000
537	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	31	ATF1(2), CREB1(1), CREB3(1), CREB5(1), DUSP10(2), EEF2K(4), ELK1(2), IL1R1(1), MAP2K3(2), MAP2K6(1), MAP3K10(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MYEF2(3), NFKB1(4), NR2C2(2), SRF(1), TRAF6(3)	31327599	42	39	42	18	7	11	13	6	5	0	0.818	1.000	1.000
538	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), BCAT1(4), BCKDHA(1), EHHADH(3), HADHB(2), HIBADH(1), IVD(1), MCCC1(4), MUT(3), OXCT1(1), PCCA(1), PCCB(2)	40777570	41	39	41	14	3	11	13	10	4	0	0.649	1.000	1.000
539	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	23	ADCY1(3), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(2), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4), SOS1(4)	26584030	38	38	38	13	8	9	7	7	7	0	0.608	1.000	1.000
540	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2)	23886453	37	37	37	14	6	8	9	6	8	0	0.737	1.000	1.000
541	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	20	ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2)	23886453	37	37	37	14	6	8	9	6	8	0	0.737	1.000	1.000
542	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(10), TAF13(1), TAF1L(9), TAF4(2), TAF4B(2), TAF5(1), TAF5L(2), TAF6(1), TAF7(1), TAF7L(2), TAF9(1)	40044984	37	37	37	12	6	9	10	7	5	0	0.611	1.000	1.000
543	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	22	CSNK2A1(1), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PDGFRA(3), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4)	30972874	41	37	41	12	9	7	9	5	11	0	0.375	1.000	1.000
544	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(4), EGF(3), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(10), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY1(1), SPRY2(1), SPRY3(3)	28381502	39	37	39	21	8	7	10	8	6	0	0.986	1.000	1.000
545	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	26	CHUK(1), EGR2(2), EGR3(2), GNAQ(1), MYC(1), NFATC2(2), NFKB1(4), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1), VIPR2(1)	26842830	37	37	37	14	4	8	9	7	9	0	0.721	1.000	1.000
546	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	28	AKR1C4(2), AKR1D1(1), ARSB(4), ARSE(2), CYP11B1(2), CYP11B2(5), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	29995524	40	36	40	15	9	6	15	8	2	0	0.612	1.000	1.000
547	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(3), ACACA(4), ACACB(9), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), HIBCH(2), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1)	44929187	39	36	39	15	2	10	14	10	3	0	0.748	1.000	1.000
548	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	ARNT(3), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(3), PLCG1(6), PTK2(5), SHC1(1)	33287136	37	35	37	16	6	9	13	5	4	0	0.786	1.000	1.000
549	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(5), AXIN1(1), BTRC(2), CCND1(1), CREBBP(7), CSNK1A1(1), CSNK2A1(1), CTNNB1(1), DVL1(2), FZD1(1), HDAC1(4), MAP3K7(1), MYC(1), NLK(2), PPP2CA(2), TLE1(2), WIF1(2)	32297770	36	35	36	16	4	9	9	7	7	0	0.913	1.000	1.000
550	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(4), AGT(2), EDN1(2), EDNRA(1), EDNRB(2), EGF(3), EGFR(5), JUN(3), MYC(1), NFKB1(4), PLCG1(6), RELA(1)	22935997	34	34	34	14	6	8	7	8	5	0	0.728	1.000	1.000
551	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	34582262	36	34	36	15	3	8	12	10	2	1	0.830	1.000	1.000
552	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(2), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2)	22005132	34	34	34	11	6	6	10	5	7	0	0.598	1.000	1.000
553	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	15	ABCB1(4), ATM(18), BAX(2), CPB2(1), CSNK1A1(1), FHL2(2), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1)	20443333	35	34	34	11	4	7	9	5	10	0	0.759	1.000	1.000
554	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	26	BCAR1(2), CRKL(1), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4)	27421105	35	34	35	12	6	9	8	5	7	0	0.468	1.000	1.000
555	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(2), EPHA4(2), EPHB1(5), ITGA1(5), ITGB1(3), L1CAM(4), LYN(4), SELP(8)	17950964	33	33	33	14	10	8	10	5	0	0	0.750	1.000	1.000
556	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	24	CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1(1), IGF1R(2), INSR(4), MAP2K6(1), MAPK14(2), MEF2B(1), MEF2C(3), MEF2D(2), NFATC2(2), PPP3CA(4), PPP3CB(3)	30704127	36	33	36	19	3	11	11	7	4	0	0.867	1.000	1.000
557	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	22	POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(3), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3)	26200314	35	33	35	17	6	4	9	7	9	0	0.943	1.000	1.000
558	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), P4HB(1), SLC23A1(2), SLC2A3(3)	29109121	35	33	35	14	7	7	11	6	4	0	0.700	1.000	1.000
559	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(2), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), REN(1)	29250009	33	32	33	14	7	6	10	5	5	0	0.801	1.000	1.000
560	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(3), ACADSB(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), MLYCD(2), UPB1(3)	32216855	34	32	34	18	4	10	10	6	4	0	0.914	1.000	1.000
561	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), CTNNA1(4), CTNNA2(8), CTNNB1(1), PTK2(5), VCL(4)	21003993	35	32	35	14	8	6	9	5	7	0	0.750	1.000	1.000
562	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), AOC2(1), AOC3(3), CES1(2), CES7(2), ESCO1(3), LIPA(1), MYST3(4), MYST4(8), PLA1A(2), PNPLA3(2), PPME1(1), SH3GLB1(1)	28264013	33	32	33	14	4	9	8	7	4	1	0.827	1.000	1.000
563	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(14), MAP2(10), PPP2CA(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2)	20565300	31	31	31	11	2	5	12	6	6	0	0.902	1.000	1.000
564	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(2), ACYP1(1), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), FN3K(1), GCDH(1), ITGB1BP3(1), MYST3(4), MYST4(8), PNPLA3(2), SH3GLB1(1)	28973800	34	31	34	15	6	6	8	11	2	1	0.849	1.000	1.000
565	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1L(1), GOSR1(1), SNAP23(2), SNAP25(2), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX2(1), STX3(2), STX4(1), STX6(2), STX7(1), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP3(1), VAMP7(1), VTI1B(1)	18337277	31	31	31	11	7	4	10	2	8	0	0.651	1.000	1.000
566	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(3), ACACA(4), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1)	37548898	33	31	33	17	1	12	10	8	2	0	0.934	1.000	1.000
567	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGFR(1), PTGIS(3), PTGS1(2), PTGS2(2), S100A6(1), TBXAS1(1)	22803981	33	31	33	13	6	5	12	8	2	0	0.790	1.000	1.000
568	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	APC(5), CREBBP(7), EP300(7), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(3), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3)	27231683	33	31	32	10	5	9	7	7	5	0	0.546	1.000	1.000
569	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ABAT(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), EHHADH(3), GAD1(2), GAD2(3), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1)	28804758	31	30	31	15	2	10	11	8	0	0	0.860	1.000	1.000
570	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3)	23274390	31	30	31	10	5	7	10	3	6	0	0.450	1.000	1.000
571	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(3), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), SRM(1), UPB1(3)	29707214	32	30	32	14	4	8	10	6	4	0	0.774	1.000	1.000
572	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPN2(3), EP300(7), HDAC1(4), HDAC2(3), MEF2D(2), NFATC2(2), PPP3CA(4), PPP3CB(3)	26213419	33	30	32	14	2	9	6	6	10	0	0.813	1.000	1.000
573	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	GNAQ(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), SP1(3), SP3(4)	21968397	32	29	32	11	1	6	10	9	6	0	0.743	1.000	1.000
574	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1)	29774155	30	29	30	14	4	5	9	8	4	0	0.911	1.000	1.000
575	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(7), ACE2(1), AGT(2), ANPEP(6), CTSA(4), CTSG(1), ENPEP(3), MAS1(2), NLN(1), REN(1), THOP1(1)	23547354	29	29	27	13	5	5	7	4	8	0	0.916	1.000	1.000
576	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	22	CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), HDAC5(3), MEF2B(1), MEF2C(3), MEF2D(2), PPARA(2), PPP3CA(4), PPP3CB(3), SLC2A4(1)	21981286	32	29	32	12	3	7	7	10	5	0	0.632	1.000	1.000
577	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(7), DYRK1B(1), GLI2(5), GLI3(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2)	16926113	32	29	32	12	6	4	11	4	7	0	0.723	1.000	1.000
578	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRB(1), CP(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2)	31009951	29	28	29	15	3	7	8	8	3	0	0.928	1.000	1.000
579	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(6), CETP(1), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(11), SCARB1(2), SOAT1(1)	29769822	28	28	28	14	5	8	9	2	4	0	0.870	1.000	1.000
580	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(3), AMT(2), ATIC(3), FTCD(1), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1)	21416257	28	27	28	11	1	7	11	4	5	0	0.802	1.000	1.000
581	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(3), ABCC2(5), ABCG2(1), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1)	26198984	27	27	27	13	6	3	7	8	3	0	0.900	1.000	1.000
582	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	22	APC(5), AXIN1(1), CCND1(1), CD14(2), CTNNB1(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(2), LBP(1), NFKB1(4), PPP2CA(2), RELA(1), TIRAP(1)	25385935	27	26	27	13	4	7	3	10	3	0	0.878	1.000	1.000
583	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(1), ELK1(2), GRB2(1), INSR(4), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1)	23391080	28	26	28	11	6	6	7	3	6	0	0.684	1.000	1.000
584	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(3), AMT(2), ATIC(3), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1)	20408586	27	26	27	11	1	7	11	3	5	0	0.821	1.000	1.000
585	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	EGFR(5), IGF1R(2), MYC(1), POLR2A(5), PPP2CA(2), TEP1(11)	27377274	26	26	26	10	5	5	7	6	3	0	0.729	1.000	1.000
586	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	23	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(3), ASPA(2), CNDP1(3), DDC(1), HAL(2), HARS(1), MAOA(2), MAOB(1), PRPS2(1)	26568635	27	24	27	11	4	6	11	2	4	0	0.690	1.000	1.000
587	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT10(2), GALNT2(1), GALNT3(2), GALNT4(1), GALNT7(4), GALNT8(3), GALNT9(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(5)	16610733	26	24	26	15	3	4	4	8	7	0	0.965	1.000	1.000
588	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	9	CR1(10), CR2(4), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3)	16214824	23	23	23	11	0	7	9	4	3	0	0.891	1.000	1.000
589	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(4), EGF(3), EGFR(5), GRB2(1), MET(7), PDGFRA(3), SH3GLB1(1), SH3KBP1(3)	22173244	27	23	27	14	6	5	6	7	3	0	0.950	1.000	1.000
590	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNAS(5), GNB1(1), PPP2CA(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	16560908	24	23	24	11	5	3	4	5	7	0	0.958	1.000	1.000
591	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	24	BAG4(1), BIRC3(1), JUN(3), MAP3K7(1), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(3), TNFAIP3(2), TNFRSF1A(1)	26134515	24	23	24	13	3	6	7	1	6	1	0.956	1.000	1.000
592	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(6), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GPHN(2), NSF(1), UBQLN1(1)	13596683	22	21	22	11	3	3	9	6	1	0	0.902	1.000	1.000
593	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(7), ABCB4(2), ABCC1(3), ABCC3(4), GSTP1(1)	16816867	21	21	21	15	2	4	9	3	3	0	0.981	1.000	1.000
594	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	19	B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GCNT2(1), ST8SIA1(1)	15615127	19	19	18	10	3	3	5	3	5	0	0.874	1.000	1.000
595	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(5), AXIN1(1), BTRC(2), CTNNB1(1), DLL1(2), DVL1(2), FZD1(1), NOTCH1(5), PSEN1(1)	21202287	20	19	20	10	2	7	2	6	3	0	0.902	1.000	1.000
596	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR24(3), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1)	21414468	16	16	16	13	5	2	6	1	2	0	0.996	1.000	1.000
597	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	10	CHRNG(2), MUSK(3), PTK2(5), PTK2B(3)	12836876	13	13	13	6	3	4	6	0	0	0	0.728	1.000	1.000
598	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	MAP2K3(2), MAPK14(2), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1)	10636826	13	13	13	10	0	2	7	1	3	0	0.984	1.000	1.000
599	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(4)	9184339	13	13	12	6	4	2	4	3	0	0	0.672	1.000	1.000
600	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(2), GPR109B(2), GPR161(2), GPR34(1), GPR45(1), GPR75(2)	11219658	12	12	12	10	2	1	3	5	1	0	0.981	1.000	1.000
601	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(1), ATF3(1), CYR61(1), IFNG(2), IFRD1(1), IL18(1), IL1A(1), IL1R1(1), NR4A3(2), WDR1(1)	12077855	12	12	12	5	3	1	5	3	0	0	0.749	1.000	1.000
602	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3)	13556469	11	11	11	9	0	4	6	1	0	0	0.975	1.000	1.000
603	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT1(2), EHHADH(3), HADHB(2)	9550156	9	9	9	6	0	3	3	3	0	0	0.929	1.000	1.000
604	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	12	CNR1(2), CNR2(1), DNMT1(4), PTGDR(1), PTGFR(1)	11136424	9	9	9	11	3	0	2	3	1	0	0.999	1.000	1.000
605	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	8825917	8	8	8	5	0	3	5	0	0	0	0.889	1.000	1.000
606	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1)	8825917	8	8	8	5	0	3	5	0	0	0	0.889	1.000	1.000
607	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ACYP1(1), EHHADH(3), GCDH(1), SDHB(1)	8825949	8	8	8	6	1	2	2	3	0	0	0.941	1.000	1.000
608	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS2(4), GATA1(1), HBB(1), HMBS(1)	9293125	7	7	7	4	3	1	3	0	0	0	0.906	1.000	1.000
609	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(1), NR0B2(2), NR1H4(1), RXRA(1)	5641024	6	6	6	4	2	0	3	1	0	0	0.893	1.000	1.000
610	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(2), CHRNA1(1), SNAP25(2)	3602521	5	5	5	4	1	0	4	0	0	0	0.931	1.000	1.000
611	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), KERA(1), LUM(2)	4134244	4	4	4	3	2	0	1	1	0	0	0.863	1.000	1.000
612	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	EHHADH(3)	5507205	3	3	3	4	0	1	1	1	0	0	0.978	1.000	1.000
613	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1), CYP2C9(2)	2325939	3	3	3	2	0	1	2	0	0	0	0.927	1.000	1.000
614	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACAT1(2)	5960466	2	2	2	3	0	1	0	1	0	0	0.976	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		584187	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	5		2957134	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
