Correlation between copy number variation genes and molecular subtypes

Overview

Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and molecular subtypes.

Summary

Testing the association between copy number variation of 70 peak regions and 10 molecular subtypes across 563 patients, 124 significant findings detected with Q value < 0.25.

Amp Peak 1(1p36.21) cnvs correlated to 'CN_CNMF'.
Amp Peak 2(1q32.1) cnvs correlated to 'CN_CNMF'.
Amp Peak 3(1q44) cnvs correlated to 'CN_CNMF'.
Amp Peak 4(2p24.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 5(3q26.33) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 7(4q12) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'CN_CNMF'.
Amp Peak 8(7p11.2) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CNMF', 'MIR_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
Amp Peak 9(7q11.21) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CNMF', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Amp Peak 10(7q21.2) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Amp Peak 11(7q31.2) cnvs correlated to 'MRNA_CNMF', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Amp Peak 12(7q36.1) cnvs correlated to 'MIR_CHIERARCHICAL' and 'CN_CNMF'.
Amp Peak 13(8q24.21) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Amp Peak 15(12p13.32) cnvs correlated to 'CN_CNMF'.
Amp Peak 16(12q14.1) cnvs correlated to 'CN_CNMF'.
Amp Peak 17(12q15) cnvs correlated to 'CN_CNMF'.
Amp Peak 21(17q25.1) cnvs correlated to 'CN_CNMF'.
Amp Peak 22(19p13.2) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', and 'RPPA_CHIERARCHICAL'.
Amp Peak 23(19q12) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', and 'RPPA_CHIERARCHICAL'.
Del Peak 7(2q22.1) cnvs correlated to 'CN_CNMF'.
Del Peak 9(3p21.1) cnvs correlated to 'CN_CNMF'.
Del Peak 10(3q13.31) cnvs correlated to 'CN_CNMF'.
Del Peak 11(3q22.1) cnvs correlated to 'CN_CNMF'.
Del Peak 14(4q34.3) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 15(5q35.3) cnvs correlated to 'MRNA_CNMF', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 16(6q22.31) cnvs correlated to 'CN_CNMF'.
Del Peak 17(6q26) cnvs correlated to 'CN_CNMF'.
Del Peak 19(9p21.3) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 21(10p15.3) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 22(10p13) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', 'CN_CNMF', and 'RPPA_CNMF'.
Del Peak 23(10p11.23) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 24(10q23.31) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 25(10q26.3) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 26(11p15.5) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', 'CN_CNMF', and 'METHLYATION_CNMF'.
Del Peak 27(11p11.2) cnvs correlated to 'MRNA_CNMF', 'MIR_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 28(11q14.1) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 29(12p13.1) cnvs correlated to 'MRNA_CNMF'.
Del Peak 30(12q12) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 31(12q15) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 32(13q14.2) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', and 'CN_CNMF'.
Del Peak 33(14q13.1) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 34(14q24.2) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 35(14q31.3) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 36(15q14) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
Del Peak 39(17p13.2) cnvs correlated to 'CN_CNMF'.
Del Peak 40(17p13.1) cnvs correlated to 'CN_CNMF'.
Del Peak 41(17q11.2) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.
Del Peak 43(19q13.41) cnvs correlated to 'MRNA_CNMF' and 'MRNA_CHIERARCHICAL'.
Del Peak 44(21q22.3) cnvs correlated to 'MIR_CNMF'.
Del Peak 46(Xp22.2) cnvs correlated to 'MRNA_CNMF' and 'CN_CNMF'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 70 regions and 10 molecular subtypes. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 124 significant findings detected.


		Molecular subtypes	MRNA CNMF	MRNA CHIERARCHICAL	MIR CNMF	MIR CHIERARCHICAL	CN CNMF	METHLYATION CNMF	RPPA CNMF	RPPA CHIERARCHICAL	MRNASEQ CNMF	MRNASEQ CHIERARCHICAL
	nCNV (%)	nWild-Type	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test
Amp Peak 8(7p11 2)	494 (88%)	69	7.02e-13 (4.78e-10)	1.62e-10 (1.1e-07)	3.48e-07 (0.000228)	2.34e-13 (1.6e-10)	1.23e-20 (8.56e-18)	1.04e-06 (0.000666)	8.62e-06 (0.00539)	5.85e-05 (0.0357)	1.11e-05 (0.0069)	0.000357 (0.206)
Del Peak 36(15q14)	151 (27%)	412	8.62e-09 (5.75e-06)	9.29e-06 (0.00581)	0.00977 (1.00)	1.31e-06 (0.000842)	4.09e-07 (0.000267)	0.000159 (0.094)	0.0699 (1.00)	0.0241 (1.00)	0.000352 (0.203)	0.158 (1.00)
Amp Peak 9(7q11 21)	452 (80%)	111	5.68e-07 (0.000368)	1.82e-05 (0.0113)	4.69e-06 (0.00296)	7.42e-09 (4.97e-06)	1.72e-09 (1.15e-06)	0.00323 (1.00)	0.00417 (1.00)	0.336 (1.00)	0.004 (1.00)	0.00143 (0.796)
Del Peak 22(10p13)	459 (82%)	104	7.95e-06 (0.00498)	2.17e-06 (0.00138)	0.00282 (1.00)	1.28e-07 (8.46e-05)	1.11e-15 (7.68e-13)	0.0272 (1.00)	0.000132 (0.0789)	0.00458 (1.00)	0.0885 (1.00)	0.41 (1.00)
Del Peak 26(11p15 5)	127 (23%)	436	7.71e-10 (5.2e-07)	7.41e-06 (0.00465)	0.23 (1.00)	1.5e-06 (0.000962)	2.1e-15 (1.44e-12)	0.000116 (0.0701)	0.268 (1.00)	0.0938 (1.00)	0.00119 (0.67)	0.263 (1.00)
Amp Peak 10(7q21 2)	468 (83%)	95	3.34e-05 (0.0205)	0.000321 (0.186)	0.0107 (1.00)	1.92e-06 (0.00122)	1.06e-10 (7.2e-08)	0.00716 (1.00)	0.0179 (1.00)	0.0964 (1.00)	0.0618 (1.00)	0.00474 (1.00)
Amp Peak 13(8q24 21)	64 (11%)	499	2.01e-07 (0.000132)	0.000157 (0.0928)	0.0397 (1.00)	8.34e-05 (0.0505)	3.51e-06 (0.00222)	0.0627 (1.00)	0.104 (1.00)	0.00574 (1.00)	0.131 (1.00)	0.345 (1.00)
Amp Peak 22(19p13 2)	240 (43%)	323	9.12e-14 (6.25e-11)	8.12e-09 (5.43e-06)	0.248 (1.00)	0.00825 (1.00)	1.86e-20 (1.29e-17)	0.0134 (1.00)	0.0116 (1.00)	1.32e-05 (0.00823)	0.164 (1.00)	0.0199 (1.00)
Amp Peak 23(19q12)	203 (36%)	360	1.24e-09 (8.32e-07)	2.1e-07 (0.000138)	0.218 (1.00)	0.00449 (1.00)	1.5e-15 (1.03e-12)	0.107 (1.00)	0.0174 (1.00)	0.000213 (0.125)	0.0823 (1.00)	0.0438 (1.00)
Del Peak 21(10p15 3)	457 (81%)	106	0.000121 (0.0727)	2.85e-05 (0.0175)	0.0133 (1.00)	1.85e-07 (0.000122)	1.45e-14 (9.97e-12)	0.0272 (1.00)	0.00523 (1.00)	0.0278 (1.00)	0.0147 (1.00)	0.41 (1.00)
Del Peak 23(10p11 23)	463 (82%)	100	5.78e-07 (0.000374)	1.97e-07 (0.00013)	0.00054 (0.309)	1.26e-08 (8.38e-06)	9.85e-17 (6.84e-14)	0.0358 (1.00)	0.000786 (0.448)	0.0175 (1.00)	0.0443 (1.00)	0.084 (1.00)
Del Peak 24(10q23 31)	499 (89%)	64	6.54e-05 (0.0397)	1.34e-05 (0.00833)	0.00781 (1.00)	7.23e-05 (0.0439)	1.19e-16 (8.24e-14)	0.142 (1.00)	0.0105 (1.00)	0.131 (1.00)	0.369 (1.00)	0.16 (1.00)
Del Peak 25(10q26 3)	500 (89%)	63	0.000123 (0.0736)	6.48e-06 (0.00407)	0.0777 (1.00)	0.00043 (0.248)	1.89e-13 (1.29e-10)	0.0135 (1.00)	0.117 (1.00)	0.0761 (1.00)	0.25 (1.00)	0.378 (1.00)
Amp Peak 7(4q12)	104 (18%)	459	0.000127 (0.0761)	5.24e-05 (0.0321)	0.479 (1.00)	0.0527 (1.00)	4.31e-07 (0.000281)	0.157 (1.00)	0.272 (1.00)	0.664 (1.00)	0.0487 (1.00)	0.403 (1.00)
Amp Peak 11(7q31 2)	460 (82%)	103	0.000129 (0.0769)	0.000497 (0.285)	0.00207 (1.00)	0.000144 (0.0857)	2.21e-07 (0.000145)	0.0378 (1.00)	0.103 (1.00)	0.183 (1.00)	0.256 (1.00)	0.00355 (1.00)
Del Peak 15(5q35 3)	54 (10%)	509	1.98e-05 (0.0122)	0.00218 (1.00)	0.00156 (0.865)	2.27e-05 (0.014)	5.69e-05 (0.0347)	0.0117 (1.00)	0.84 (1.00)	0.407 (1.00)	0.208 (1.00)	0.841 (1.00)
Del Peak 19(9p21 3)	408 (72%)	155	4.19e-06 (0.00265)	7.98e-07 (0.000514)	0.554 (1.00)	0.00153 (0.848)	3.77e-10 (2.55e-07)	0.0118 (1.00)	0.0878 (1.00)	0.0182 (1.00)	0.0274 (1.00)	0.00319 (1.00)
Del Peak 27(11p11 2)	101 (18%)	462	4.49e-07 (0.000293)	0.000993 (0.562)	0.921 (1.00)	2.44e-05 (0.015)	2.18e-13 (1.49e-10)	0.000874 (0.497)	0.825 (1.00)	0.576 (1.00)	0.051 (1.00)	0.706 (1.00)
Del Peak 31(12q15)	77 (14%)	486	0.000307 (0.179)	0.000163 (0.0962)	0.247 (1.00)	0.0467 (1.00)	5.4e-07 (0.00035)	0.229 (1.00)	0.527 (1.00)	0.724 (1.00)	0.585 (1.00)	0.943 (1.00)
Del Peak 32(13q14 2)	236 (42%)	327	4.76e-07 (0.00031)	1.6e-06 (0.00102)	0.109 (1.00)	0.08 (1.00)	1.1e-15 (7.63e-13)	0.0305 (1.00)	0.794 (1.00)	0.107 (1.00)	0.0921 (1.00)	0.193 (1.00)
Amp Peak 5(3q26 33)	108 (19%)	455	0.0511 (1.00)	0.558 (1.00)	0.9 (1.00)	0.724 (1.00)	3.56e-06 (0.00225)	0.000291 (0.17)	0.0685 (1.00)	0.358 (1.00)	0.546 (1.00)	0.321 (1.00)
Amp Peak 12(7q36 1)	465 (83%)	98	0.00103 (0.582)	0.00339 (1.00)	0.059 (1.00)	4.59e-05 (0.0281)	1.41e-05 (0.00879)	0.00716 (1.00)	0.227 (1.00)	0.249 (1.00)	0.0292 (1.00)	0.00467 (1.00)
Del Peak 14(4q34 3)	90 (16%)	473	0.000101 (0.0611)	0.012 (1.00)	0.088 (1.00)	0.0519 (1.00)	0.000153 (0.0908)	0.061 (1.00)	0.0967 (1.00)	0.283 (1.00)	0.125 (1.00)	0.96 (1.00)
Del Peak 28(11q14 1)	95 (17%)	468	0.000308 (0.179)	0.0149 (1.00)	0.936 (1.00)	0.00783 (1.00)	1.3e-16 (9e-14)	0.236 (1.00)	0.552 (1.00)	0.5 (1.00)	0.0908 (1.00)	0.793 (1.00)
Del Peak 30(12q12)	76 (13%)	487	0.000178 (0.105)	0.00242 (1.00)	0.188 (1.00)	0.0064 (1.00)	0.000175 (0.103)	0.0889 (1.00)	0.137 (1.00)	0.489 (1.00)	0.941 (1.00)	0.868 (1.00)
Del Peak 33(14q13 1)	175 (31%)	388	7.17e-07 (0.000462)	0.0329 (1.00)	0.618 (1.00)	0.421 (1.00)	3.36e-30 (2.34e-27)	0.106 (1.00)	0.577 (1.00)	0.367 (1.00)	0.291 (1.00)	0.742 (1.00)
Del Peak 34(14q24 2)	170 (30%)	393	9.66e-08 (6.39e-05)	0.00349 (1.00)	0.0656 (1.00)	0.871 (1.00)	7.68e-39 (5.36e-36)	0.0327 (1.00)	0.457 (1.00)	0.275 (1.00)	0.0497 (1.00)	0.142 (1.00)
Del Peak 35(14q31 3)	156 (28%)	407	1.31e-08 (8.73e-06)	0.00191 (1.00)	0.422 (1.00)	0.835 (1.00)	8.42e-41 (5.89e-38)	0.00829 (1.00)	0.515 (1.00)	0.108 (1.00)	0.222 (1.00)	0.0846 (1.00)
Del Peak 41(17q11 2)	71 (13%)	492	7.39e-05 (0.0448)	0.000724 (0.414)	0.00192 (1.00)	0.00959 (1.00)	5.32e-07 (0.000345)	0.644 (1.00)	0.00594 (1.00)	0.00512 (1.00)	0.539 (1.00)	0.104 (1.00)
Del Peak 43(19q13 41)	99 (18%)	464	1.99e-06 (0.00127)	0.000191 (0.112)	0.0018 (0.996)	0.00108 (0.61)	0.0012 (0.674)	0.619 (1.00)	0.0401 (1.00)	0.574 (1.00)	0.02 (1.00)	0.0941 (1.00)
Del Peak 46(Xp22 2)	123 (22%)	440	0.000346 (0.201)	0.0224 (1.00)	0.155 (1.00)	0.209 (1.00)	6.6e-10 (4.46e-07)	0.00753 (1.00)	0.605 (1.00)	0.253 (1.00)	0.337 (1.00)	0.644 (1.00)
Amp Peak 1(1p36 21)	89 (16%)	474	0.941 (1.00)	0.236 (1.00)	0.179 (1.00)	0.0074 (1.00)	1.63e-08 (1.08e-05)	0.448 (1.00)	0.048 (1.00)	0.0531 (1.00)	0.0967 (1.00)	0.0808 (1.00)
Amp Peak 2(1q32 1)	153 (27%)	410	0.727 (1.00)	0.638 (1.00)	0.239 (1.00)	0.097 (1.00)	1.76e-08 (1.17e-05)	0.35 (1.00)	0.84 (1.00)	0.335 (1.00)	0.475 (1.00)	0.095 (1.00)
Amp Peak 3(1q44)	96 (17%)	467	0.883 (1.00)	0.501 (1.00)	0.403 (1.00)	0.441 (1.00)	8.32e-09 (5.56e-06)	0.59 (1.00)	0.426 (1.00)	0.177 (1.00)	0.775 (1.00)	0.439 (1.00)
Amp Peak 4(2p24 3)	46 (8%)	517	0.00404 (1.00)	0.0824 (1.00)	0.748 (1.00)	0.385 (1.00)	0.000238 (0.139)	0.0289 (1.00)	0.209 (1.00)	0.112 (1.00)	0.93 (1.00)	1 (1.00)
Amp Peak 15(12p13 32)	81 (14%)	482	0.867 (1.00)	0.641 (1.00)	0.716 (1.00)	0.812 (1.00)	1.96e-05 (0.0121)	0.234 (1.00)	0.411 (1.00)	0.553 (1.00)	0.442 (1.00)	0.151 (1.00)
Amp Peak 16(12q14 1)	131 (23%)	432	0.084 (1.00)	0.283 (1.00)	0.309 (1.00)	0.121 (1.00)	1.7e-09 (1.15e-06)	0.347 (1.00)	0.0452 (1.00)	0.338 (1.00)	0.0335 (1.00)	0.0543 (1.00)
Amp Peak 17(12q15)	92 (16%)	471	0.749 (1.00)	0.377 (1.00)	0.751 (1.00)	0.515 (1.00)	2.83e-07 (0.000185)	0.404 (1.00)	0.273 (1.00)	0.649 (1.00)	0.333 (1.00)	0.349 (1.00)
Amp Peak 21(17q25 1)	78 (14%)	485	0.0605 (1.00)	0.646 (1.00)	0.402 (1.00)	0.709 (1.00)	5.98e-05 (0.0364)	0.643 (1.00)	0.13 (1.00)	0.292 (1.00)	1 (1.00)	0.417 (1.00)
Del Peak 7(2q22 1)	44 (8%)	519	0.0281 (1.00)	0.098 (1.00)	0.437 (1.00)	0.0651 (1.00)	1.6e-06 (0.00102)	0.00219 (1.00)	0.478 (1.00)	0.86 (1.00)	0.181 (1.00)	0.21 (1.00)
Del Peak 9(3p21 1)	52 (9%)	511	0.0665 (1.00)	0.47 (1.00)	0.911 (1.00)	0.104 (1.00)	0.000187 (0.11)	0.271 (1.00)	0.134 (1.00)	0.855 (1.00)	0.461 (1.00)	0.0959 (1.00)
Del Peak 10(3q13 31)	55 (10%)	508	0.367 (1.00)	0.776 (1.00)	0.98 (1.00)	0.708 (1.00)	5.68e-06 (0.00358)	0.203 (1.00)	0.87 (1.00)	0.797 (1.00)	1 (1.00)	0.0547 (1.00)
Del Peak 11(3q22 1)	55 (10%)	508	0.46 (1.00)	0.639 (1.00)	0.617 (1.00)	0.378 (1.00)	0.000235 (0.137)	0.372 (1.00)	0.859 (1.00)	0.892 (1.00)	1 (1.00)	0.103 (1.00)
Del Peak 16(6q22 31)	153 (27%)	410	0.873 (1.00)	0.639 (1.00)	0.554 (1.00)	0.029 (1.00)	9.83e-11 (6.68e-08)	0.113 (1.00)	0.204 (1.00)	0.192 (1.00)	0.796 (1.00)	0.426 (1.00)
Del Peak 17(6q26)	173 (31%)	390	0.775 (1.00)	0.244 (1.00)	0.866 (1.00)	0.125 (1.00)	1.08e-06 (0.000694)	0.758 (1.00)	0.0166 (1.00)	0.0111 (1.00)	0.761 (1.00)	0.292 (1.00)
Del Peak 29(12p13 1)	75 (13%)	488	0.000154 (0.0912)	0.00113 (0.635)	0.129 (1.00)	0.056 (1.00)	0.077 (1.00)	0.595 (1.00)	0.875 (1.00)	0.522 (1.00)	0.944 (1.00)	0.566 (1.00)
Del Peak 39(17p13 2)	85 (15%)	478	0.207 (1.00)	0.629 (1.00)	0.926 (1.00)	0.8 (1.00)	2e-10 (1.35e-07)	0.277 (1.00)	0.632 (1.00)	0.487 (1.00)	0.587 (1.00)	0.261 (1.00)
Del Peak 40(17p13 1)	95 (17%)	468	0.0371 (1.00)	0.179 (1.00)	0.88 (1.00)	0.605 (1.00)	1.42e-15 (9.77e-13)	0.104 (1.00)	0.709 (1.00)	0.447 (1.00)	0.645 (1.00)	0.295 (1.00)
Del Peak 44(21q22 3)	59 (10%)	504	0.00148 (0.826)	0.0184 (1.00)	0.000108 (0.065)	0.00239 (1.00)	0.14 (1.00)	0.145 (1.00)	0.39 (1.00)	0.121 (1.00)	1 (1.00)	0.119 (1.00)
Amp Peak 6(4p16 3)	46 (8%)	517	0.876 (1.00)	0.603 (1.00)	0.828 (1.00)	0.403 (1.00)	0.465 (1.00)	0.162 (1.00)	0.636 (1.00)	0.53 (1.00)	0.941 (1.00)	0.759 (1.00)
Amp Peak 14(11p13)	26 (5%)	537	0.411 (1.00)	0.827 (1.00)	0.324 (1.00)	0.769 (1.00)	0.452 (1.00)	0.285 (1.00)	0.265 (1.00)	0.112 (1.00)	0.602 (1.00)	1 (1.00)
Amp Peak 18(13q34)	30 (5%)	533	0.536 (1.00)	0.758 (1.00)	0.17 (1.00)	0.115 (1.00)	0.014 (1.00)		0.0677 (1.00)	0.186 (1.00)	0.368 (1.00)	1 (1.00)
Amp Peak 19(14q32 33)	34 (6%)	529	0.35 (1.00)	0.473 (1.00)	0.0211 (1.00)	0.943 (1.00)	0.794 (1.00)	1 (1.00)	0.0394 (1.00)	0.275 (1.00)	0.0429 (1.00)	0.884 (1.00)
Amp Peak 20(17p13 2)	45 (8%)	518	0.00231 (1.00)	0.0327 (1.00)	0.0751 (1.00)	0.221 (1.00)	0.00696 (1.00)	0.527 (1.00)	0.0545 (1.00)	0.63 (1.00)	0.615 (1.00)	0.281 (1.00)
Amp Peak 24(21q21 1)	67 (12%)	496	0.000446 (0.256)	0.00771 (1.00)	0.108 (1.00)	0.0796 (1.00)	0.000771 (0.44)	0.748 (1.00)	0.669 (1.00)	0.83 (1.00)	0.0967 (1.00)	0.0663 (1.00)
Del Peak 1(1p36 32)	99 (18%)	464	0.219 (1.00)	0.0293 (1.00)	0.503 (1.00)	0.233 (1.00)	0.614 (1.00)	0.577 (1.00)	0.545 (1.00)	0.561 (1.00)	0.252 (1.00)	0.0437 (1.00)
Del Peak 2(1p36 23)	135 (24%)	428	0.0405 (1.00)	0.0639 (1.00)	0.369 (1.00)	0.33 (1.00)	0.00118 (0.664)	0.493 (1.00)	0.279 (1.00)	0.725 (1.00)	0.0632 (1.00)	0.103 (1.00)
Del Peak 3(1p32 3)	60 (11%)	503	0.359 (1.00)	0.439 (1.00)	0.97 (1.00)	0.871 (1.00)	0.0973 (1.00)	0.686 (1.00)	0.706 (1.00)	0.63 (1.00)	0.803 (1.00)	0.159 (1.00)
Del Peak 4(1p22 1)	47 (8%)	516	0.793 (1.00)	0.839 (1.00)	0.761 (1.00)	0.228 (1.00)	0.176 (1.00)	0.271 (1.00)	0.888 (1.00)	0.372 (1.00)	1 (1.00)	0.015 (1.00)
Del Peak 5(1q42 11)	47 (8%)	516	0.771 (1.00)	0.836 (1.00)	0.402 (1.00)	0.679 (1.00)	0.619 (1.00)	0.528 (1.00)	0.161 (1.00)	0.00286 (1.00)	0.686 (1.00)	0.647 (1.00)
Del Peak 6(1q44)	32 (6%)	531	0.601 (1.00)	0.29 (1.00)	0.685 (1.00)	0.315 (1.00)	0.612 (1.00)	0.292 (1.00)	0.799 (1.00)	0.335 (1.00)	0.539 (1.00)	0.904 (1.00)
Del Peak 8(2q37 1)	56 (10%)	507	0.0154 (1.00)	0.0147 (1.00)	0.239 (1.00)	0.00097 (0.55)	0.00684 (1.00)	0.0122 (1.00)	0.647 (1.00)	0.72 (1.00)	0.181 (1.00)	0.687 (1.00)
Del Peak 12(3q29)	64 (11%)	499	0.115 (1.00)	0.137 (1.00)	0.612 (1.00)	0.984 (1.00)	0.00683 (1.00)	0.139 (1.00)	0.379 (1.00)	0.684 (1.00)	0.954 (1.00)	0.731 (1.00)
Del Peak 13(4p16 3)	78 (14%)	485	0.0158 (1.00)	0.0359 (1.00)	0.35 (1.00)	0.178 (1.00)	0.0582 (1.00)	1 (1.00)	0.832 (1.00)	0.71 (1.00)	0.872 (1.00)	0.818 (1.00)
Del Peak 18(8p23 2)	67 (12%)	496	0.581 (1.00)	0.133 (1.00)	0.256 (1.00)	0.355 (1.00)	0.0382 (1.00)	0.898 (1.00)	0.951 (1.00)	0.946 (1.00)	0.62 (1.00)	0.159 (1.00)
Del Peak 20(9q34 2)	71 (13%)	492	0.292 (1.00)	0.0617 (1.00)	0.84 (1.00)	0.401 (1.00)	0.292 (1.00)	0.823 (1.00)	0.113 (1.00)	0.241 (1.00)	0.442 (1.00)	0.0569 (1.00)
Del Peak 37(16p12 2)	89 (16%)	474	0.302 (1.00)	0.558 (1.00)	0.0617 (1.00)	0.578 (1.00)	0.0942 (1.00)	0.31 (1.00)	0.405 (1.00)	0.535 (1.00)	0.443 (1.00)	0.422 (1.00)
Del Peak 38(16q23 3)	95 (17%)	468	0.153 (1.00)	0.313 (1.00)	0.752 (1.00)	1 (1.00)	0.0045 (1.00)	0.651 (1.00)	0.0385 (1.00)	0.0802 (1.00)	0.528 (1.00)	0.468 (1.00)
Del Peak 42(18q22 3)	79 (14%)	484	0.0572 (1.00)	0.323 (1.00)	0.498 (1.00)	0.421 (1.00)	0.00203 (1.00)	0.0169 (1.00)	0.0315 (1.00)	0.00134 (0.747)	0.159 (1.00)	0.697 (1.00)
Del Peak 45(22q13 32)	208 (37%)	355	0.705 (1.00)	0.432 (1.00)	0.0194 (1.00)	0.088 (1.00)	0.000804 (0.458)	0.752 (1.00)	0.915 (1.00)	0.941 (1.00)	0.0721 (1.00)	0.923 (1.00)

'Amp Peak 1(1p36.21) mutation analysis' versus 'CN_CNMF'

P value = 1.63e-08 (Fisher's exact test), Q value = 1.1e-05

Table S1. Gene #1: 'Amp Peak 1(1p36.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 1(1P36.21) MUTATED	50	20	19
AMP PEAK 1(1P36.21) WILD-TYPE	111	194	169

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p36.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 2(1q32.1) mutation analysis' versus 'CN_CNMF'

P value = 1.76e-08 (Fisher's exact test), Q value = 1.2e-05

Table S2. Gene #2: 'Amp Peak 2(1q32.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 2(1Q32.1) MUTATED	73	43	37
AMP PEAK 2(1Q32.1) WILD-TYPE	88	171	151

Figure S2. Get High-res Image Gene #2: 'Amp Peak 2(1q32.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 3(1q44) mutation analysis' versus 'CN_CNMF'

P value = 8.32e-09 (Fisher's exact test), Q value = 5.6e-06

Table S3. Gene #3: 'Amp Peak 3(1q44) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 3(1Q44) MUTATED	53	21	22
AMP PEAK 3(1Q44) WILD-TYPE	108	193	166

Figure S3. Get High-res Image Gene #3: 'Amp Peak 3(1q44) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 4(2p24.3) mutation analysis' versus 'CN_CNMF'

P value = 0.000238 (Fisher's exact test), Q value = 0.14

Table S4. Gene #4: 'Amp Peak 4(2p24.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 4(2P24.3) MUTATED	24	7	15
AMP PEAK 4(2P24.3) WILD-TYPE	137	207	173

Figure S4. Get High-res Image Gene #4: 'Amp Peak 4(2p24.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 5(3q26.33) mutation analysis' versus 'CN_CNMF'

P value = 3.56e-06 (Fisher's exact test), Q value = 0.0023

Table S5. Gene #5: 'Amp Peak 5(3q26.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 5(3Q26.33) MUTATED	52	25	31
AMP PEAK 5(3Q26.33) WILD-TYPE	109	189	157

Figure S5. Get High-res Image Gene #5: 'Amp Peak 5(3q26.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 5(3q26.33) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000291 (Fisher's exact test), Q value = 0.17

Table S6. Gene #5: 'Amp Peak 5(3q26.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	38	20	24	27
AMP PEAK 5(3Q26.33) MUTATED	3	6	1	12
AMP PEAK 5(3Q26.33) WILD-TYPE	35	14	23	15

Figure S6. Get High-res Image Gene #5: 'Amp Peak 5(3q26.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 7(4q12) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000127 (Fisher's exact test), Q value = 0.076

Table S7. Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 7(4Q12) MUTATED	24	51	23
AMP PEAK 7(4Q12) WILD-TYPE	148	119	144

Figure S7. Get High-res Image Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 7(4q12) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 5.24e-05 (Fisher's exact test), Q value = 0.032

Table S8. Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 7(4Q12) MUTATED	30	17	51
AMP PEAK 7(4Q12) WILD-TYPE	187	109	115

Figure S8. Get High-res Image Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 7(4q12) mutation analysis' versus 'CN_CNMF'

P value = 4.31e-07 (Fisher's exact test), Q value = 0.00028

Table S9. Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 7(4Q12) MUTATED	52	22	30
AMP PEAK 7(4Q12) WILD-TYPE	109	192	158

Figure S9. Get High-res Image Gene #7: 'Amp Peak 7(4q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MRNA_CNMF'

P value = 7.02e-13 (Fisher's exact test), Q value = 4.8e-10

Table S10. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 8(7P11.2) MUTATED	160	121	162
AMP PEAK 8(7P11.2) WILD-TYPE	12	49	5

Figure S10. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.62e-10 (Fisher's exact test), Q value = 1.1e-07

Table S11. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 8(7P11.2) MUTATED	202	121	120
AMP PEAK 8(7P11.2) WILD-TYPE	15	5	46

Figure S11. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MIR_CNMF'

P value = 3.48e-07 (Fisher's exact test), Q value = 0.00023

Table S12. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	139	157	72	104
AMP PEAK 8(7P11.2) MUTATED	136	124	58	95
AMP PEAK 8(7P11.2) WILD-TYPE	3	33	14	9

Figure S12. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 2.34e-13 (Fisher's exact test), Q value = 1.6e-10

Table S13. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 8(7P11.2) MUTATED	153	172	88
AMP PEAK 8(7P11.2) WILD-TYPE	10	7	42

Figure S13. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 8(7p11.2) mutation analysis' versus 'CN_CNMF'

P value = 1.23e-20 (Fisher's exact test), Q value = 8.6e-18

Table S14. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 8(7P11.2) MUTATED	149	213	132
AMP PEAK 8(7P11.2) WILD-TYPE	12	1	56

Figure S14. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 1.04e-06 (Fisher's exact test), Q value = 0.00067

Table S15. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	38	20	24	27
AMP PEAK 8(7P11.2) MUTATED	37	20	24	16
AMP PEAK 8(7P11.2) WILD-TYPE	1	0	0	11

Figure S15. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'RPPA_CNMF'

P value = 8.62e-06 (Fisher's exact test), Q value = 0.0054

Table S16. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #7: 'RPPA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	54	58	44	45
AMP PEAK 8(7P11.2) MUTATED	49	42	44	44
AMP PEAK 8(7P11.2) WILD-TYPE	5	16	0	1

Figure S16. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #7: 'RPPA_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'RPPA_CHIERARCHICAL'

P value = 5.85e-05 (Fisher's exact test), Q value = 0.036

Table S17. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	64	33	104
AMP PEAK 8(7P11.2) MUTATED	64	31	84
AMP PEAK 8(7P11.2) WILD-TYPE	0	2	20

Figure S17. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MRNASEQ_CNMF'

P value = 1.11e-05 (Fisher's exact test), Q value = 0.0069

Table S18. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	44	67	36
AMP PEAK 8(7P11.2) MUTATED	31	66	34
AMP PEAK 8(7P11.2) WILD-TYPE	13	1	2

Figure S18. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

'Amp Peak 8(7p11.2) mutation analysis' versus 'MRNASEQ_CHIERARCHICAL'

P value = 0.000357 (Fisher's exact test), Q value = 0.21

Table S19. Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #10: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	66	21	60
AMP PEAK 8(7P11.2) MUTATED	64	21	46
AMP PEAK 8(7P11.2) WILD-TYPE	2	0	14

Figure S19. Get High-res Image Gene #8: 'Amp Peak 8(7p11.2) mutation analysis' versus Clinical Feature #10: 'MRNASEQ_CHIERARCHICAL'

'Amp Peak 9(7q11.21) mutation analysis' versus 'MRNA_CNMF'

P value = 5.68e-07 (Fisher's exact test), Q value = 0.00037

Table S20. Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 9(7Q11.21) MUTATED	153	112	138
AMP PEAK 9(7Q11.21) WILD-TYPE	19	58	29

Figure S20. Get High-res Image Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 9(7q11.21) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.82e-05 (Fisher's exact test), Q value = 0.011

Table S21. Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 9(7Q11.21) MUTATED	189	102	112
AMP PEAK 9(7Q11.21) WILD-TYPE	28	24	54

Figure S21. Get High-res Image Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 9(7q11.21) mutation analysis' versus 'MIR_CNMF'

P value = 4.69e-06 (Fisher's exact test), Q value = 0.003

Table S22. Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	139	157	72	104
AMP PEAK 9(7Q11.21) MUTATED	126	113	48	90
AMP PEAK 9(7Q11.21) WILD-TYPE	13	44	24	14

Figure S22. Get High-res Image Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

'Amp Peak 9(7q11.21) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 7.42e-09 (Fisher's exact test), Q value = 5e-06

Table S23. Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 9(7Q11.21) MUTATED	143	155	79
AMP PEAK 9(7Q11.21) WILD-TYPE	20	24	51

Figure S23. Get High-res Image Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 9(7q11.21) mutation analysis' versus 'CN_CNMF'

P value = 1.72e-09 (Fisher's exact test), Q value = 1.2e-06

Table S24. Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 9(7Q11.21) MUTATED	144	186	122
AMP PEAK 9(7Q11.21) WILD-TYPE	17	28	66

Figure S24. Get High-res Image Gene #9: 'Amp Peak 9(7q11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 10(7q21.2) mutation analysis' versus 'MRNA_CNMF'

P value = 3.34e-05 (Fisher's exact test), Q value = 0.021

Table S25. Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 10(7Q21.2) MUTATED	152	121	146
AMP PEAK 10(7Q21.2) WILD-TYPE	20	49	21

Figure S25. Get High-res Image Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 10(7q21.2) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 0.000321 (Fisher's exact test), Q value = 0.19

Table S26. Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 10(7Q21.2) MUTATED	189	110	120
AMP PEAK 10(7Q21.2) WILD-TYPE	28	16	46

Figure S26. Get High-res Image Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 10(7q21.2) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.92e-06 (Fisher's exact test), Q value = 0.0012

Table S27. Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 10(7Q21.2) MUTATED	140	160	87
AMP PEAK 10(7Q21.2) WILD-TYPE	23	19	43

Figure S27. Get High-res Image Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 10(7q21.2) mutation analysis' versus 'CN_CNMF'

P value = 1.06e-10 (Fisher's exact test), Q value = 7.2e-08

Table S28. Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 10(7Q21.2) MUTATED	145	196	127
AMP PEAK 10(7Q21.2) WILD-TYPE	16	18	61

Figure S28. Get High-res Image Gene #10: 'Amp Peak 10(7q21.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 11(7q31.2) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000129 (Fisher's exact test), Q value = 0.077

Table S29. Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 11(7Q31.2) MUTATED	154	122	137
AMP PEAK 11(7Q31.2) WILD-TYPE	18	48	30

Figure S29. Get High-res Image Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 11(7q31.2) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 0.000144 (Fisher's exact test), Q value = 0.086

Table S30. Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 11(7Q31.2) MUTATED	141	151	88
AMP PEAK 11(7Q31.2) WILD-TYPE	22	28	42

Figure S30. Get High-res Image Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 11(7q31.2) mutation analysis' versus 'CN_CNMF'

P value = 2.21e-07 (Fisher's exact test), Q value = 0.00014

Table S31. Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 11(7Q31.2) MUTATED	141	190	129
AMP PEAK 11(7Q31.2) WILD-TYPE	20	24	59

Figure S31. Get High-res Image Gene #11: 'Amp Peak 11(7q31.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 12(7q36.1) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 4.59e-05 (Fisher's exact test), Q value = 0.028

Table S32. Gene #12: 'Amp Peak 12(7q36.1) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 12(7Q36.1) MUTATED	138	158	89
AMP PEAK 12(7Q36.1) WILD-TYPE	25	21	41

Figure S32. Get High-res Image Gene #12: 'Amp Peak 12(7q36.1) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 12(7q36.1) mutation analysis' versus 'CN_CNMF'

P value = 1.41e-05 (Fisher's exact test), Q value = 0.0088

Table S33. Gene #12: 'Amp Peak 12(7q36.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 12(7Q36.1) MUTATED	139	191	135
AMP PEAK 12(7Q36.1) WILD-TYPE	22	23	53

Figure S33. Get High-res Image Gene #12: 'Amp Peak 12(7q36.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNA_CNMF'

P value = 2.01e-07 (Fisher's exact test), Q value = 0.00013

Table S34. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 13(8Q24.21) MUTATED	12	38	7
AMP PEAK 13(8Q24.21) WILD-TYPE	160	132	160

Figure S34. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 0.000157 (Fisher's exact test), Q value = 0.093

Table S35. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 13(8Q24.21) MUTATED	16	8	33
AMP PEAK 13(8Q24.21) WILD-TYPE	201	118	133

Figure S35. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 8.34e-05 (Fisher's exact test), Q value = 0.05

Table S36. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
AMP PEAK 13(8Q24.21) MUTATED	12	13	29
AMP PEAK 13(8Q24.21) WILD-TYPE	151	166	101

Figure S36. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 13(8q24.21) mutation analysis' versus 'CN_CNMF'

P value = 3.51e-06 (Fisher's exact test), Q value = 0.0022

Table S37. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 13(8Q24.21) MUTATED	31	8	25
AMP PEAK 13(8Q24.21) WILD-TYPE	130	206	163

Figure S37. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 15(12p13.32) mutation analysis' versus 'CN_CNMF'

P value = 1.96e-05 (Fisher's exact test), Q value = 0.012

Table S38. Gene #15: 'Amp Peak 15(12p13.32) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 15(12P13.32) MUTATED	41	18	22
AMP PEAK 15(12P13.32) WILD-TYPE	120	196	166

Figure S38. Get High-res Image Gene #15: 'Amp Peak 15(12p13.32) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 16(12q14.1) mutation analysis' versus 'CN_CNMF'

P value = 1.7e-09 (Fisher's exact test), Q value = 1.1e-06

Table S39. Gene #16: 'Amp Peak 16(12q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 16(12Q14.1) MUTATED	67	37	27
AMP PEAK 16(12Q14.1) WILD-TYPE	94	177	161

Figure S39. Get High-res Image Gene #16: 'Amp Peak 16(12q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 17(12q15) mutation analysis' versus 'CN_CNMF'

P value = 2.83e-07 (Fisher's exact test), Q value = 0.00019

Table S40. Gene #17: 'Amp Peak 17(12q15) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 17(12Q15) MUTATED	49	24	19
AMP PEAK 17(12Q15) WILD-TYPE	112	190	169

Figure S40. Get High-res Image Gene #17: 'Amp Peak 17(12q15) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 21(17q25.1) mutation analysis' versus 'CN_CNMF'

P value = 5.98e-05 (Fisher's exact test), Q value = 0.036

Table S41. Gene #21: 'Amp Peak 21(17q25.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 21(17Q25.1) MUTATED	39	18	21
AMP PEAK 21(17Q25.1) WILD-TYPE	122	196	167

Figure S41. Get High-res Image Gene #21: 'Amp Peak 21(17q25.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 22(19p13.2) mutation analysis' versus 'MRNA_CNMF'

P value = 9.12e-14 (Fisher's exact test), Q value = 6.2e-11

Table S42. Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 22(19P13.2) MUTATED	65	43	110
AMP PEAK 22(19P13.2) WILD-TYPE	107	127	57

Figure S42. Get High-res Image Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 22(19p13.2) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 8.12e-09 (Fisher's exact test), Q value = 5.4e-06

Table S43. Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 22(19P13.2) MUTATED	89	81	48
AMP PEAK 22(19P13.2) WILD-TYPE	128	45	118

Figure S43. Get High-res Image Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 22(19p13.2) mutation analysis' versus 'CN_CNMF'

P value = 1.86e-20 (Fisher's exact test), Q value = 1.3e-17

Table S44. Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 22(19P13.2) MUTATED	47	145	48
AMP PEAK 22(19P13.2) WILD-TYPE	114	69	140

Figure S44. Get High-res Image Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 22(19p13.2) mutation analysis' versus 'RPPA_CHIERARCHICAL'

P value = 1.32e-05 (Fisher's exact test), Q value = 0.0082

Table S45. Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	64	33	104
AMP PEAK 22(19P13.2) MUTATED	42	8	34
AMP PEAK 22(19P13.2) WILD-TYPE	22	25	70

Figure S45. Get High-res Image Gene #22: 'Amp Peak 22(19p13.2) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

'Amp Peak 23(19q12) mutation analysis' versus 'MRNA_CNMF'

P value = 1.24e-09 (Fisher's exact test), Q value = 8.3e-07

Table S46. Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
AMP PEAK 23(19Q12) MUTATED	66	32	86
AMP PEAK 23(19Q12) WILD-TYPE	106	138	81

Figure S46. Get High-res Image Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 23(19q12) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 2.1e-07 (Fisher's exact test), Q value = 0.00014

Table S47. Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
AMP PEAK 23(19Q12) MUTATED	84	65	35
AMP PEAK 23(19Q12) WILD-TYPE	133	61	131

Figure S47. Get High-res Image Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 23(19q12) mutation analysis' versus 'CN_CNMF'

P value = 1.5e-15 (Fisher's exact test), Q value = 1e-12

Table S48. Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
AMP PEAK 23(19Q12) MUTATED	38	123	42
AMP PEAK 23(19Q12) WILD-TYPE	123	91	146

Figure S48. Get High-res Image Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 23(19q12) mutation analysis' versus 'RPPA_CHIERARCHICAL'

P value = 0.000213 (Fisher's exact test), Q value = 0.12

Table S49. Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	64	33	104
AMP PEAK 23(19Q12) MUTATED	35	7	27
AMP PEAK 23(19Q12) WILD-TYPE	29	26	77

Figure S49. Get High-res Image Gene #23: 'Amp Peak 23(19q12) mutation analysis' versus Clinical Feature #8: 'RPPA_CHIERARCHICAL'

'Del Peak 7(2q22.1) mutation analysis' versus 'CN_CNMF'

P value = 1.6e-06 (Fisher's exact test), Q value = 0.001

Table S50. Gene #31: 'Del Peak 7(2q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 7(2Q22.1) MUTATED	26	4	14
DEL PEAK 7(2Q22.1) WILD-TYPE	135	210	174

Figure S50. Get High-res Image Gene #31: 'Del Peak 7(2q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 9(3p21.1) mutation analysis' versus 'CN_CNMF'

P value = 0.000187 (Fisher's exact test), Q value = 0.11

Table S51. Gene #33: 'Del Peak 9(3p21.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 9(3P21.1) MUTATED	23	7	22
DEL PEAK 9(3P21.1) WILD-TYPE	138	207	166

Figure S51. Get High-res Image Gene #33: 'Del Peak 9(3p21.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 10(3q13.31) mutation analysis' versus 'CN_CNMF'

P value = 5.68e-06 (Fisher's exact test), Q value = 0.0036

Table S52. Gene #34: 'Del Peak 10(3q13.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 10(3Q13.31) MUTATED	27	6	22
DEL PEAK 10(3Q13.31) WILD-TYPE	134	208	166

Figure S52. Get High-res Image Gene #34: 'Del Peak 10(3q13.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 11(3q22.1) mutation analysis' versus 'CN_CNMF'

P value = 0.000235 (Fisher's exact test), Q value = 0.14

Table S53. Gene #35: 'Del Peak 11(3q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 11(3Q22.1) MUTATED	24	8	23
DEL PEAK 11(3Q22.1) WILD-TYPE	137	206	165

Figure S53. Get High-res Image Gene #35: 'Del Peak 11(3q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 14(4q34.3) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000101 (Fisher's exact test), Q value = 0.061

Table S54. Gene #38: 'Del Peak 14(4q34.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 14(4Q34.3) MUTATED	18	45	20
DEL PEAK 14(4Q34.3) WILD-TYPE	154	125	147

Figure S54. Get High-res Image Gene #38: 'Del Peak 14(4q34.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 14(4q34.3) mutation analysis' versus 'CN_CNMF'

P value = 0.000153 (Fisher's exact test), Q value = 0.091

Table S55. Gene #38: 'Del Peak 14(4q34.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 14(4Q34.3) MUTATED	41	20	29
DEL PEAK 14(4Q34.3) WILD-TYPE	120	194	159

Figure S55. Get High-res Image Gene #38: 'Del Peak 14(4q34.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 15(5q35.3) mutation analysis' versus 'MRNA_CNMF'

P value = 1.98e-05 (Fisher's exact test), Q value = 0.012

Table S56. Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 15(5Q35.3) MUTATED	12	32	7
DEL PEAK 15(5Q35.3) WILD-TYPE	160	138	160

Figure S56. Get High-res Image Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 15(5q35.3) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 2.27e-05 (Fisher's exact test), Q value = 0.014

Table S57. Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 15(5Q35.3) MUTATED	6	15	26
DEL PEAK 15(5Q35.3) WILD-TYPE	157	164	104

Figure S57. Get High-res Image Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 15(5q35.3) mutation analysis' versus 'CN_CNMF'

P value = 5.69e-05 (Fisher's exact test), Q value = 0.035

Table S58. Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 15(5Q35.3) MUTATED	18	7	29
DEL PEAK 15(5Q35.3) WILD-TYPE	143	207	159

Figure S58. Get High-res Image Gene #39: 'Del Peak 15(5q35.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 16(6q22.31) mutation analysis' versus 'CN_CNMF'

P value = 9.83e-11 (Fisher's exact test), Q value = 6.7e-08

Table S59. Gene #40: 'Del Peak 16(6q22.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 16(6Q22.31) MUTATED	77	42	34
DEL PEAK 16(6Q22.31) WILD-TYPE	84	172	154

Figure S59. Get High-res Image Gene #40: 'Del Peak 16(6q22.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 17(6q26) mutation analysis' versus 'CN_CNMF'

P value = 1.08e-06 (Fisher's exact test), Q value = 0.00069

Table S60. Gene #41: 'Del Peak 17(6q26) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 17(6Q26) MUTATED	75	58	40
DEL PEAK 17(6Q26) WILD-TYPE	86	156	148

Figure S60. Get High-res Image Gene #41: 'Del Peak 17(6q26) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 19(9p21.3) mutation analysis' versus 'MRNA_CNMF'

P value = 4.19e-06 (Fisher's exact test), Q value = 0.0026

Table S61. Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 19(9P21.3) MUTATED	115	111	144
DEL PEAK 19(9P21.3) WILD-TYPE	57	59	23

Figure S61. Get High-res Image Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 19(9p21.3) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 7.98e-07 (Fisher's exact test), Q value = 0.00051

Table S62. Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 19(9P21.3) MUTATED	149	113	108
DEL PEAK 19(9P21.3) WILD-TYPE	68	13	58

Figure S62. Get High-res Image Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 19(9p21.3) mutation analysis' versus 'CN_CNMF'

P value = 3.77e-10 (Fisher's exact test), Q value = 2.5e-07

Table S63. Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 19(9P21.3) MUTATED	108	187	113
DEL PEAK 19(9P21.3) WILD-TYPE	53	27	75

Figure S63. Get High-res Image Gene #43: 'Del Peak 19(9p21.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 21(10p15.3) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000121 (Fisher's exact test), Q value = 0.073

Table S64. Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 21(10P15.3) MUTATED	145	118	145
DEL PEAK 21(10P15.3) WILD-TYPE	27	52	22

Figure S64. Get High-res Image Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 21(10p15.3) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 2.85e-05 (Fisher's exact test), Q value = 0.018

Table S65. Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 21(10P15.3) MUTATED	182	112	114
DEL PEAK 21(10P15.3) WILD-TYPE	35	14	52

Figure S65. Get High-res Image Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 21(10p15.3) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.85e-07 (Fisher's exact test), Q value = 0.00012

Table S66. Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 21(10P15.3) MUTATED	143	154	82
DEL PEAK 21(10P15.3) WILD-TYPE	20	25	48

Figure S66. Get High-res Image Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 21(10p15.3) mutation analysis' versus 'CN_CNMF'

P value = 1.45e-14 (Fisher's exact test), Q value = 1e-11

Table S67. Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 21(10P15.3) MUTATED	137	201	119
DEL PEAK 21(10P15.3) WILD-TYPE	24	13	69

Figure S67. Get High-res Image Gene #45: 'Del Peak 21(10p15.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 22(10p13) mutation analysis' versus 'MRNA_CNMF'

P value = 7.95e-06 (Fisher's exact test), Q value = 0.005

Table S68. Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 22(10P13) MUTATED	148	116	146
DEL PEAK 22(10P13) WILD-TYPE	24	54	21

Figure S68. Get High-res Image Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 22(10p13) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 2.17e-06 (Fisher's exact test), Q value = 0.0014

Table S69. Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 22(10P13) MUTATED	186	112	112
DEL PEAK 22(10P13) WILD-TYPE	31	14	54

Figure S69. Get High-res Image Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 22(10p13) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.28e-07 (Fisher's exact test), Q value = 8.5e-05

Table S70. Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 22(10P13) MUTATED	145	154	83
DEL PEAK 22(10P13) WILD-TYPE	18	25	47

Figure S70. Get High-res Image Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 22(10p13) mutation analysis' versus 'CN_CNMF'

P value = 1.11e-15 (Fisher's exact test), Q value = 7.7e-13

Table S71. Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 22(10P13) MUTATED	137	203	119
DEL PEAK 22(10P13) WILD-TYPE	24	11	69

Figure S71. Get High-res Image Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 22(10p13) mutation analysis' versus 'RPPA_CNMF'

P value = 0.000132 (Fisher's exact test), Q value = 0.079

Table S72. Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #7: 'RPPA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	54	58	44	45
DEL PEAK 22(10P13) MUTATED	50	38	42	37
DEL PEAK 22(10P13) WILD-TYPE	4	20	2	8

Figure S72. Get High-res Image Gene #46: 'Del Peak 22(10p13) mutation analysis' versus Clinical Feature #7: 'RPPA_CNMF'

'Del Peak 23(10p11.23) mutation analysis' versus 'MRNA_CNMF'

P value = 5.78e-07 (Fisher's exact test), Q value = 0.00037

Table S73. Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 23(10P11.23) MUTATED	145	118	153
DEL PEAK 23(10P11.23) WILD-TYPE	27	52	14

Figure S73. Get High-res Image Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 23(10p11.23) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.97e-07 (Fisher's exact test), Q value = 0.00013

Table S74. Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 23(10P11.23) MUTATED	185	117	114
DEL PEAK 23(10P11.23) WILD-TYPE	32	9	52

Figure S74. Get High-res Image Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 23(10p11.23) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.26e-08 (Fisher's exact test), Q value = 8.4e-06

Table S75. Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 23(10P11.23) MUTATED	145	159	83
DEL PEAK 23(10P11.23) WILD-TYPE	18	20	47

Figure S75. Get High-res Image Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 23(10p11.23) mutation analysis' versus 'CN_CNMF'

P value = 9.85e-17 (Fisher's exact test), Q value = 6.8e-14

Table S76. Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 23(10P11.23) MUTATED	138	205	120
DEL PEAK 23(10P11.23) WILD-TYPE	23	9	68

Figure S76. Get High-res Image Gene #47: 'Del Peak 23(10p11.23) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 24(10q23.31) mutation analysis' versus 'MRNA_CNMF'

P value = 6.54e-05 (Fisher's exact test), Q value = 0.04

Table S77. Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 24(10Q23.31) MUTATED	154	136	159
DEL PEAK 24(10Q23.31) WILD-TYPE	18	34	8

Figure S77. Get High-res Image Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 24(10q23.31) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.34e-05 (Fisher's exact test), Q value = 0.0083

Table S78. Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 24(10Q23.31) MUTATED	195	122	132
DEL PEAK 24(10Q23.31) WILD-TYPE	22	4	34

Figure S78. Get High-res Image Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 24(10q23.31) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 7.23e-05 (Fisher's exact test), Q value = 0.044

Table S79. Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 24(10Q23.31) MUTATED	150	167	101
DEL PEAK 24(10Q23.31) WILD-TYPE	13	12	29

Figure S79. Get High-res Image Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 24(10q23.31) mutation analysis' versus 'CN_CNMF'

P value = 1.19e-16 (Fisher's exact test), Q value = 8.2e-14

Table S80. Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 24(10Q23.31) MUTATED	149	212	138
DEL PEAK 24(10Q23.31) WILD-TYPE	12	2	50

Figure S80. Get High-res Image Gene #48: 'Del Peak 24(10q23.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 25(10q26.3) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000123 (Fisher's exact test), Q value = 0.074

Table S81. Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 25(10Q26.3) MUTATED	154	137	159
DEL PEAK 25(10Q26.3) WILD-TYPE	18	33	8

Figure S81. Get High-res Image Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 25(10q26.3) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 6.48e-06 (Fisher's exact test), Q value = 0.0041

Table S82. Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 25(10Q26.3) MUTATED	194	123	133
DEL PEAK 25(10Q26.3) WILD-TYPE	23	3	33

Figure S82. Get High-res Image Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 25(10q26.3) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 0.00043 (Fisher's exact test), Q value = 0.25

Table S83. Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 25(10Q26.3) MUTATED	147	168	103
DEL PEAK 25(10Q26.3) WILD-TYPE	16	11	27

Figure S83. Get High-res Image Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 25(10q26.3) mutation analysis' versus 'CN_CNMF'

P value = 1.89e-13 (Fisher's exact test), Q value = 1.3e-10

Table S84. Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 25(10Q26.3) MUTATED	147	211	142
DEL PEAK 25(10Q26.3) WILD-TYPE	14	3	46

Figure S84. Get High-res Image Gene #49: 'Del Peak 25(10q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 26(11p15.5) mutation analysis' versus 'MRNA_CNMF'

P value = 7.71e-10 (Fisher's exact test), Q value = 5.2e-07

Table S85. Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 26(11P15.5) MUTATED	40	65	15
DEL PEAK 26(11P15.5) WILD-TYPE	132	105	152

Figure S85. Get High-res Image Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 26(11p15.5) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 7.41e-06 (Fisher's exact test), Q value = 0.0047

Table S86. Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 26(11P15.5) MUTATED	48	14	58
DEL PEAK 26(11P15.5) WILD-TYPE	169	112	108

Figure S86. Get High-res Image Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 26(11p15.5) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.5e-06 (Fisher's exact test), Q value = 0.00096

Table S87. Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 26(11P15.5) MUTATED	29	32	54
DEL PEAK 26(11P15.5) WILD-TYPE	134	147	76

Figure S87. Get High-res Image Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 26(11p15.5) mutation analysis' versus 'CN_CNMF'

P value = 2.1e-15 (Fisher's exact test), Q value = 1.4e-12

Table S88. Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 26(11P15.5) MUTATED	63	13	51
DEL PEAK 26(11P15.5) WILD-TYPE	98	201	137

Figure S88. Get High-res Image Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 26(11p15.5) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000116 (Fisher's exact test), Q value = 0.07

Table S89. Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	38	20	24	27
DEL PEAK 26(11P15.5) MUTATED	0	4	1	9
DEL PEAK 26(11P15.5) WILD-TYPE	38	16	23	18

Figure S89. Get High-res Image Gene #50: 'Del Peak 26(11p15.5) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 27(11p11.2) mutation analysis' versus 'MRNA_CNMF'

P value = 4.49e-07 (Fisher's exact test), Q value = 0.00029

Table S90. Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 27(11P11.2) MUTATED	33	50	12
DEL PEAK 27(11P11.2) WILD-TYPE	139	120	155

Figure S90. Get High-res Image Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 27(11p11.2) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 2.44e-05 (Fisher's exact test), Q value = 0.015

Table S91. Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 27(11P11.2) MUTATED	29	20	42
DEL PEAK 27(11P11.2) WILD-TYPE	134	159	88

Figure S91. Get High-res Image Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 27(11p11.2) mutation analysis' versus 'CN_CNMF'

P value = 2.18e-13 (Fisher's exact test), Q value = 1.5e-10

Table S92. Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 27(11P11.2) MUTATED	55	10	36
DEL PEAK 27(11P11.2) WILD-TYPE	106	204	152

Figure S92. Get High-res Image Gene #51: 'Del Peak 27(11p11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 28(11q14.1) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000308 (Fisher's exact test), Q value = 0.18

Table S93. Gene #52: 'Del Peak 28(11q14.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 28(11Q14.1) MUTATED	35	40	14
DEL PEAK 28(11Q14.1) WILD-TYPE	137	130	153

Figure S93. Get High-res Image Gene #52: 'Del Peak 28(11q14.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 28(11q14.1) mutation analysis' versus 'CN_CNMF'

P value = 1.3e-16 (Fisher's exact test), Q value = 9e-14

Table S94. Gene #52: 'Del Peak 28(11q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 28(11Q14.1) MUTATED	61	10	24
DEL PEAK 28(11Q14.1) WILD-TYPE	100	204	164

Figure S94. Get High-res Image Gene #52: 'Del Peak 28(11q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 29(12p13.1) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000154 (Fisher's exact test), Q value = 0.091

Table S95. Gene #53: 'Del Peak 29(12p13.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 29(12P13.1) MUTATED	20	36	10
DEL PEAK 29(12P13.1) WILD-TYPE	152	134	157

Figure S95. Get High-res Image Gene #53: 'Del Peak 29(12p13.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 30(12q12) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000178 (Fisher's exact test), Q value = 0.1

Table S96. Gene #54: 'Del Peak 30(12q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 30(12Q12) MUTATED	19	38	12
DEL PEAK 30(12Q12) WILD-TYPE	153	132	155

Figure S96. Get High-res Image Gene #54: 'Del Peak 30(12q12) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 30(12q12) mutation analysis' versus 'CN_CNMF'

P value = 0.000175 (Fisher's exact test), Q value = 0.1

Table S97. Gene #54: 'Del Peak 30(12q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 30(12Q12) MUTATED	35	15	26
DEL PEAK 30(12Q12) WILD-TYPE	126	199	162

Figure S97. Get High-res Image Gene #54: 'Del Peak 30(12q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 31(12q15) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000307 (Fisher's exact test), Q value = 0.18

Table S98. Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 31(12Q15) MUTATED	24	35	10
DEL PEAK 31(12Q15) WILD-TYPE	148	135	157

Figure S98. Get High-res Image Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 31(12q15) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 0.000163 (Fisher's exact test), Q value = 0.096

Table S99. Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 31(12Q15) MUTATED	28	6	35
DEL PEAK 31(12Q15) WILD-TYPE	189	120	131

Figure S99. Get High-res Image Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 31(12q15) mutation analysis' versus 'CN_CNMF'

P value = 5.4e-07 (Fisher's exact test), Q value = 0.00035

Table S100. Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 31(12Q15) MUTATED	40	12	25
DEL PEAK 31(12Q15) WILD-TYPE	121	202	163

Figure S100. Get High-res Image Gene #55: 'Del Peak 31(12q15) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 32(13q14.2) mutation analysis' versus 'MRNA_CNMF'

P value = 4.76e-07 (Fisher's exact test), Q value = 0.00031

Table S101. Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 32(13Q14.2) MUTATED	90	82	43
DEL PEAK 32(13Q14.2) WILD-TYPE	82	88	124

Figure S101. Get High-res Image Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 32(13q14.2) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.6e-06 (Fisher's exact test), Q value = 0.001

Table S102. Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 32(13Q14.2) MUTATED	107	29	79
DEL PEAK 32(13Q14.2) WILD-TYPE	110	97	87

Figure S102. Get High-res Image Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 32(13q14.2) mutation analysis' versus 'CN_CNMF'

P value = 1.1e-15 (Fisher's exact test), Q value = 7.6e-13

Table S103. Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 32(13Q14.2) MUTATED	100	46	90
DEL PEAK 32(13Q14.2) WILD-TYPE	61	168	98

Figure S103. Get High-res Image Gene #56: 'Del Peak 32(13q14.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 33(14q13.1) mutation analysis' versus 'MRNA_CNMF'

P value = 7.17e-07 (Fisher's exact test), Q value = 0.00046

Table S104. Gene #57: 'Del Peak 33(14q13.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 33(14Q13.1) MUTATED	67	68	28
DEL PEAK 33(14Q13.1) WILD-TYPE	105	102	139

Figure S104. Get High-res Image Gene #57: 'Del Peak 33(14q13.1) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 33(14q13.1) mutation analysis' versus 'CN_CNMF'

P value = 3.36e-30 (Fisher's exact test), Q value = 2.3e-27

Table S105. Gene #57: 'Del Peak 33(14q13.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 33(14Q13.1) MUTATED	104	20	51
DEL PEAK 33(14Q13.1) WILD-TYPE	57	194	137

Figure S105. Get High-res Image Gene #57: 'Del Peak 33(14q13.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 34(14q24.2) mutation analysis' versus 'MRNA_CNMF'

P value = 9.66e-08 (Fisher's exact test), Q value = 6.4e-05

Table S106. Gene #58: 'Del Peak 34(14q24.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 34(14Q24.2) MUTATED	61	74	27
DEL PEAK 34(14Q24.2) WILD-TYPE	111	96	140

Figure S106. Get High-res Image Gene #58: 'Del Peak 34(14q24.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 34(14q24.2) mutation analysis' versus 'CN_CNMF'

P value = 7.68e-39 (Fisher's exact test), Q value = 5.4e-36

Table S107. Gene #58: 'Del Peak 34(14q24.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 34(14Q24.2) MUTATED	107	11	52
DEL PEAK 34(14Q24.2) WILD-TYPE	54	203	136

Figure S107. Get High-res Image Gene #58: 'Del Peak 34(14q24.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 35(14q31.3) mutation analysis' versus 'MRNA_CNMF'

P value = 1.31e-08 (Fisher's exact test), Q value = 8.7e-06

Table S108. Gene #59: 'Del Peak 35(14q31.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 35(14Q31.3) MUTATED	61	66	21
DEL PEAK 35(14Q31.3) WILD-TYPE	111	104	146

Figure S108. Get High-res Image Gene #59: 'Del Peak 35(14q31.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 35(14q31.3) mutation analysis' versus 'CN_CNMF'

P value = 8.42e-41 (Fisher's exact test), Q value = 5.9e-38

Table S109. Gene #59: 'Del Peak 35(14q31.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 35(14Q31.3) MUTATED	102	6	48
DEL PEAK 35(14Q31.3) WILD-TYPE	59	208	140

Figure S109. Get High-res Image Gene #59: 'Del Peak 35(14q31.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 36(15q14) mutation analysis' versus 'MRNA_CNMF'

P value = 8.62e-09 (Fisher's exact test), Q value = 5.8e-06

Table S110. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 36(15Q14) MUTATED	42	74	24
DEL PEAK 36(15Q14) WILD-TYPE	130	96	143

Figure S110. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 36(15q14) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 9.29e-06 (Fisher's exact test), Q value = 0.0058

Table S111. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 36(15Q14) MUTATED	53	20	67
DEL PEAK 36(15Q14) WILD-TYPE	164	106	99

Figure S111. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 36(15q14) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 1.31e-06 (Fisher's exact test), Q value = 0.00084

Table S112. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	163	179	130
DEL PEAK 36(15Q14) MUTATED	24	52	54
DEL PEAK 36(15Q14) WILD-TYPE	139	127	76

Figure S112. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Del Peak 36(15q14) mutation analysis' versus 'CN_CNMF'

P value = 4.09e-07 (Fisher's exact test), Q value = 0.00027

Table S113. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 36(15Q14) MUTATED	69	39	43
DEL PEAK 36(15Q14) WILD-TYPE	92	175	145

Figure S113. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 36(15q14) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000159 (Fisher's exact test), Q value = 0.094

Table S114. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	38	20	24	27
DEL PEAK 36(15Q14) MUTATED	4	7	0	11
DEL PEAK 36(15Q14) WILD-TYPE	34	13	24	16

Figure S114. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 36(15q14) mutation analysis' versus 'MRNASEQ_CNMF'

P value = 0.000352 (Fisher's exact test), Q value = 0.2

Table S115. Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	44	67	36
DEL PEAK 36(15Q14) MUTATED	24	14	7
DEL PEAK 36(15Q14) WILD-TYPE	20	53	29

Figure S115. Get High-res Image Gene #60: 'Del Peak 36(15q14) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

'Del Peak 39(17p13.2) mutation analysis' versus 'CN_CNMF'

P value = 2e-10 (Fisher's exact test), Q value = 1.4e-07

Table S116. Gene #63: 'Del Peak 39(17p13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 39(17P13.2) MUTATED	43	8	34
DEL PEAK 39(17P13.2) WILD-TYPE	118	206	154

Figure S116. Get High-res Image Gene #63: 'Del Peak 39(17p13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 40(17p13.1) mutation analysis' versus 'CN_CNMF'

P value = 1.42e-15 (Fisher's exact test), Q value = 9.8e-13

Table S117. Gene #64: 'Del Peak 40(17p13.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 40(17P13.1) MUTATED	53	6	36
DEL PEAK 40(17P13.1) WILD-TYPE	108	208	152

Figure S117. Get High-res Image Gene #64: 'Del Peak 40(17p13.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 41(17q11.2) mutation analysis' versus 'MRNA_CNMF'

P value = 7.39e-05 (Fisher's exact test), Q value = 0.045

Table S118. Gene #65: 'Del Peak 41(17q11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 41(17Q11.2) MUTATED	36	10	16
DEL PEAK 41(17Q11.2) WILD-TYPE	136	160	151

Figure S118. Get High-res Image Gene #65: 'Del Peak 41(17q11.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 41(17q11.2) mutation analysis' versus 'CN_CNMF'

P value = 5.32e-07 (Fisher's exact test), Q value = 0.00035

Table S119. Gene #65: 'Del Peak 41(17q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 41(17Q11.2) MUTATED	31	8	32
DEL PEAK 41(17Q11.2) WILD-TYPE	130	206	156

Figure S119. Get High-res Image Gene #65: 'Del Peak 41(17q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 43(19q13.41) mutation analysis' versus 'MRNA_CNMF'

P value = 1.99e-06 (Fisher's exact test), Q value = 0.0013

Table S120. Gene #67: 'Del Peak 43(19q13.41) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 43(19Q13.41) MUTATED	23	52	17
DEL PEAK 43(19Q13.41) WILD-TYPE	149	118	150

Figure S120. Get High-res Image Gene #67: 'Del Peak 43(19q13.41) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 43(19q13.41) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 0.000191 (Fisher's exact test), Q value = 0.11

Table S121. Gene #67: 'Del Peak 43(19q13.41) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	217	126	166
DEL PEAK 43(19Q13.41) MUTATED	34	12	46
DEL PEAK 43(19Q13.41) WILD-TYPE	183	114	120

Figure S121. Get High-res Image Gene #67: 'Del Peak 43(19q13.41) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 44(21q22.3) mutation analysis' versus 'MIR_CNMF'

P value = 0.000108 (Fisher's exact test), Q value = 0.065

Table S122. Gene #68: 'Del Peak 44(21q22.3) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4
ALL	139	157	72	104
DEL PEAK 44(21Q22.3) MUTATED	8	32	8	5
DEL PEAK 44(21Q22.3) WILD-TYPE	131	125	64	99

Figure S122. Get High-res Image Gene #68: 'Del Peak 44(21q22.3) mutation analysis' versus Clinical Feature #3: 'MIR_CNMF'

'Del Peak 46(Xp22.2) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000346 (Fisher's exact test), Q value = 0.2

Table S123. Gene #70: 'Del Peak 46(Xp22.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	172	170	167
DEL PEAK 46(XP22.2) MUTATED	27	57	34
DEL PEAK 46(XP22.2) WILD-TYPE	145	113	133

Figure S123. Get High-res Image Gene #70: 'Del Peak 46(Xp22.2) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 46(Xp22.2) mutation analysis' versus 'CN_CNMF'

P value = 6.6e-10 (Fisher's exact test), Q value = 4.5e-07

Table S124. Gene #70: 'Del Peak 46(Xp22.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	161	214	188
DEL PEAK 46(XP22.2) MUTATED	65	29	29
DEL PEAK 46(XP22.2) WILD-TYPE	96	185	159

Figure S124. Get High-res Image Gene #70: 'Del Peak 46(Xp22.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

Methods & Data

Input

Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
Molecular subtype file = GBM-TP.transferedmergedcluster.txt
Number of patients = 563
Number of copy number variation regions = 70
Number of molecular subtypes = 10
Exclude regions that fewer than K tumors have alterations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

References

[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[2] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

[3] GISTIC_version2

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