rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	ATM(4), ATR(4), CASP9(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), CHEK2(1), DDB2(1), GADD45B(1), GTSE1(1), IGF1(2), LRDD(1), MDM2(2), MDM4(1), PPM1D(1), PTEN(90), RPRM(1), RRM2(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN3(1), SFN(1), THBS1(2), TP53(96), TSC2(4)	27921280	235	164	181	17	42	44	28	51	70	0	4.33e-14	<1.00e-15	<3.24e-14
2	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	CRKL(1), DOCK1(2), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(2), MAPK3(1), MAPK8(1), MET(3), PAK1(1), PIK3CA(33), PIK3R1(33), PTEN(90), PTK2B(3), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1)	18896094	192	150	164	5	21	37	25	38	71	0	<1.00e-15	<1.00e-15	<3.24e-14
3	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2S2(1), EIF2S3(2), GSK3B(1), IGF1(2), IGF1R(3), INPPL1(3), PIK3CA(33), PIK3R1(33), PTEN(90)	8404717	169	142	141	3	11	32	23	31	72	0	2.11e-14	<1.00e-15	<3.24e-14
4	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), CDKN1B(1), CDKN2A(2), CREB1(1), ERBB4(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(4), IRS4(3), MET(3), MYC(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PARD3(1), PIK3CA(33), PREX1(5), PTEN(90), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(4), YWHAE(2), YWHAH(1)	32949675	173	142	151	13	21	34	25	30	63	0	1.18e-09	<1.00e-15	<3.24e-14
5	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(4), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PRKCA(1), PTEN(90)	11981597	168	138	140	4	13	33	23	29	70	0	2.18e-13	<1.00e-15	<3.24e-14
6	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), CDKN1B(1), ITGB1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PTEN(90), SOS1(3)	8259361	165	137	137	0	11	33	24	29	68	0	<1.00e-15	<1.00e-15	<3.24e-14
7	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(2), CDKN2A(2), MDM2(2), MYC(1), PIK3CA(33), PIK3R1(33), POLR1A(2), POLR1B(1), RB1(24), TP53(96)	8591371	196	136	146	2	36	27	24	38	70	1	<1.00e-15	<1.00e-15	<3.24e-14
8	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(2), ATM(4), ATR(4), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), GSK3B(1), RB1(24), SKP2(1), TFDP1(1), TP53(96)	12803078	141	103	102	4	30	18	15	33	44	1	5.53e-13	<1.00e-15	<3.24e-14
9	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(4), BCL2(2), CCNE1(1), CDKN1A(1), MDM2(2), RB1(24), TIMP3(1), TP53(96)	7755533	131	96	92	3	30	16	13	26	45	1	2.65e-12	<1.00e-15	<3.24e-14
10	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(4), CHEK1(3), RB1(24), TP53(96), WEE1(1), YWHAH(1)	7513078	129	95	90	2	30	15	14	27	42	1	1.07e-12	<1.00e-15	<3.24e-14
11	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(10), AKT1(1), ATM(4), CDKN1A(1), CSNK1D(1), MAPK8(1), MDM2(2), NQO1(1), TP53(96)	8903376	117	94	80	5	35	19	13	27	23	0	2.64e-10	<1.00e-15	<3.24e-14
12	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), PIK3CA(33), PIK3R1(33), RB1(24), SP1(1)	8302291	107	91	92	4	10	17	13	15	51	1	1.04e-07	<1.00e-15	<3.24e-14
13	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(4), ATR(4), CHEK1(3), CHEK2(1), TP53(96), YWHAH(1)	6817324	109	91	72	4	30	17	15	27	20	0	1.64e-08	<1.00e-15	<3.24e-14
14	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), AGTR2(1), EGF(3), EGFR(92), FOS(1), MYC(1), NFKB1(1), PLCG1(6), PRKCA(1)	8738982	108	83	60	13	14	45	4	39	6	0	1.54e-06	<1.00e-15	<3.24e-14
15	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(3), AKT1(1), BCL2(2), CSF2RB(4), IGF1(2), IGF1R(3), IL3(1), IL3RA(2), KIT(3), KITLG(1), PIK3CA(33), PIK3R1(33), PRKAR1B(1), PRKAR2B(1), YWHAH(1)	9349389	91	78	79	6	15	14	13	19	30	0	1.23e-05	<1.00e-15	<3.24e-14
16	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(3), AKT1(1), ASAH1(1), GNB1(1), ITGAV(1), ITGB3(1), MAPK1(2), MAPK3(1), PDGFRA(13), PIK3CA(33), PIK3R1(33), PLCB1(1), PRKCA(1), SRC(2)	11710923	94	78	82	3	11	21	14	19	29	0	5.25e-08	<1.00e-15	<3.24e-14
17	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(2), FOS(1), INS(1), INSR(2), IRS1(4), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(33), PIK3R1(33), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	10880147	88	77	77	7	9	15	14	21	29	0	0.000126	<1.00e-15	<3.24e-14
18	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), IGF1R(3), IRS1(4), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOS1(3), YWHAH(1)	8052250	83	72	72	4	7	13	16	17	30	0	1.45e-05	<1.00e-15	<3.24e-14
19	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(33), PIK3R1(33), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(4)	5453576	79	70	68	3	8	13	13	16	29	0	8.88e-06	<1.00e-15	<3.24e-14
20	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	MAX(2), MYC(1), SP1(1), SP3(1), TP53(96), WT1(2)	3008531	103	84	66	3	30	17	11	25	20	0	1.64e-11	1.55e-15	4.46e-14
21	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), BCL2(2), EGFR(92), IGF1R(3), MYC(1), POLR2A(2), PRKCA(1), RB1(24), TEP1(4), TERT(3), TNKS(1), TP53(96), XRCC5(1)	12060741	231	154	144	15	43	63	15	59	50	1	<1.00e-15	1.67e-15	4.46e-14
22	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PTEN(90), PTK2B(3), SOS1(3)	8687515	133	118	111	3	13	30	19	21	50	0	2.03e-12	1.67e-15	4.46e-14
23	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(3), F2(2), F2RL3(2), GNB1(1), MAP3K7(3), PIK3CA(33), PIK3R1(33), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(3), ROCK1(2)	11066807	85	71	74	3	13	15	12	15	30	0	7.02e-07	1.67e-15	4.46e-14
24	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CDKN1A(1), CDKN1B(1), CDKN2A(2), MDM2(2), PRB1(1), TP53(96)	3550685	103	83	66	2	30	16	12	24	21	0	3.37e-12	2.00e-15	5.13e-14
25	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(2), MAP2K1(1), MAP3K1(6), MAPK3(1), MAPK8(1), MYC(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOS1(3), STAT1(2), STAT5B(1)	11949151	90	81	77	4	8	16	14	20	32	0	2.69e-06	2.11e-15	5.20e-14
26	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	FOS(1), JAK2(2), MAP2K1(1), MAPK3(1), MPL(3), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1), STAT5B(1), THPO(1)	12745076	90	80	79	3	11	14	14	21	30	0	5.88e-07	2.44e-15	5.79e-14
27	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), NTRK1(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), SOS1(3)	6636512	78	70	67	3	7	13	13	17	28	0	6.03e-06	2.66e-15	5.83e-14
28	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), BTK(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), PIK3CA(33), PTEN(90), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(2), YWHAH(1)	15341122	147	128	125	6	15	36	19	25	52	0	6.52e-12	2.78e-15	5.83e-14
29	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), MAPK8(1), PDGFRA(13), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1)	14885763	108	92	94	6	10	24	17	25	32	0	2.80e-07	2.78e-15	5.83e-14
30	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(1), EGF(3), EGFR(92), MET(3), PDGFRA(13), PRKCA(1), SRC(2)	8273467	116	88	67	12	12	50	5	42	7	0	4.08e-07	2.89e-15	5.83e-14
31	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), ITGB1BP3(1), MIOX(1), OCRL(2), PI4KA(1), PI4KB(2), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PTEN(90), SYNJ2(3)	31774557	178	142	156	19	29	35	22	35	57	0	3.22e-08	3.11e-15	5.83e-14
32	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(92), MAP2K1(1), MAP3K1(6), NCOR2(2), RXRA(3), THRA(1)	7420482	108	85	58	14	13	49	3	36	7	0	4.74e-06	3.11e-15	5.83e-14
33	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BTK(1), CAD(3), CASP10(1), CASP8AP2(1), CD7(2), DAXX(3), DEDD(1), DEDD2(1), EGFR(92), EPHB2(3), FAF1(1), IL1A(1), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), TP53(96), TPX2(2)	31398704	241	163	154	25	53	73	25	63	27	0	1.48e-13	3.22e-15	5.83e-14
34	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), GH1(1), IGF1(2), IGF1R(3), PIK3CA(33), PIK3R1(33)	5664082	73	66	62	3	5	13	12	16	27	0	2.47e-05	3.22e-15	5.83e-14
35	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNG(1), MUSK(1), PIK3CA(33), PIK3R1(33), PTK2B(3), SRC(2), TERT(3), YWHAH(1)	7009001	78	71	67	2	10	13	12	15	28	0	5.00e-07	3.44e-15	5.96e-14
36	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(4), ATR(4), BRCA1(4), BRCA2(4), CHEK1(3), CHEK2(1), FANCD2(2), MRE11A(1), RAD50(1), TP53(96)	18786883	120	99	83	6	34	19	17	30	20	0	3.79e-09	3.55e-15	5.96e-14
37	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), CALM1(1), EGFR(92), ELK1(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1)	14356270	123	96	73	11	17	53	7	38	8	0	7.02e-09	3.66e-15	5.96e-14
38	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(4), IRS4(3), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(1), PIK3CA(33), PIK3R1(33), PPYR1(1), PTEN(90), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(2), SOS1(3), YWHAE(2), YWHAH(1)	25306438	193	154	165	10	15	37	27	36	78	0	4.23e-12	3.77e-15	5.96e-14
39	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(3), EGFR(92), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), MAPK8(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1)	15982553	190	136	129	16	20	63	17	56	34	0	1.48e-10	3.77e-15	5.96e-14
40	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(2), IFNGR1(1), IFNGR2(3), IKBKB(1), JAK2(2), NFKB1(1), NFKBIA(1), RB1(24), TNFRSF1A(1), TNFRSF1B(1), TP53(96), USH1C(1), WT1(2)	7860768	136	99	97	3	31	16	15	31	42	1	2.79e-14	3.89e-15	5.98e-14
41	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(5), EP300(1), FYN(1), IL7(1), IL7R(2), JAK1(2), JAK3(2), PIK3CA(33), PIK3R1(33), PTK2B(3), STAT5B(1)	11984332	86	78	75	9	10	15	13	15	33	0	0.00134	4.11e-15	6.08e-14
42	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1), TP53(96)	4230354	100	82	63	2	30	15	12	24	19	0	7.03e-11	4.44e-15	6.08e-14
43	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(92), NRG1(2)	4382233	97	79	49	11	10	44	2	36	5	0	1.88e-05	4.44e-15	6.08e-14
44	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), PIK3CA(33), PIK3R1(33), PTEN(90), TSC2(4)	11814928	165	139	137	2	12	33	21	30	69	0	3.33e-15	4.66e-15	6.08e-14
45	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), BTK(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), NR0B2(1), PIK3CA(33), PITX2(3), PLCG2(3), PREX1(5), PTEN(90), PTPRC(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(4)	23699196	167	138	145	16	26	40	21	23	57	0	1.83e-09	4.88e-15	6.08e-14
46	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), GZMB(2), MAP3K1(6), MCL1(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(2), TP53(96), TRAF1(1)	16022305	123	95	84	9	35	20	15	29	24	0	2.31e-09	5.11e-15	6.08e-14
47	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(3)	12446685	83	74	72	1	13	14	13	16	27	0	4.08e-08	5.11e-15	6.08e-14
48	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(1), CHUK(1), GH1(1), NFKB1(1), NFKBIA(1), PIK3CA(33), PIK3R1(33), YWHAH(1)	6021256	73	65	62	2	6	13	12	15	27	0	4.24e-06	5.11e-15	6.08e-14
49	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC2(1), PAK1(1), PDGFRA(13), PIK3CA(33), PIK3R1(33)	5689200	81	71	69	2	5	16	13	17	30	0	1.78e-06	5.22e-15	6.08e-14
50	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(4), CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MYC(1), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLE(1), POLE2(1), PRIM1(1), RB1(24), RBL1(2), RPA2(1), TFDP1(1), TNXB(3), TP53(96), WEE1(1)	32954033	177	121	138	11	36	23	19	43	55	1	3.66e-12	5.33e-15	6.08e-14
51	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(5), DAXX(3), PAX3(3), RB1(24), SP100(2), TNFRSF1A(1), TNFRSF1B(1), TP53(96)	8201049	135	96	96	7	32	18	13	28	43	1	4.75e-11	5.33e-15	6.08e-14
52	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(33), PIK3R1(33), PLCG1(6), RAF1(1), SOS1(3)	8164304	82	73	71	1	8	13	14	19	28	0	5.58e-08	5.33e-15	6.08e-14
53	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(4), ATR(4), BRCA1(4), CDKN1A(1), CHEK1(3), CHEK2(1), EP300(1), MDM2(2), PRKDC(4), RPS6KA1(1), TP53(96), WEE1(1), YWHAH(1)	18098950	123	97	86	9	35	22	15	28	23	0	2.50e-08	5.44e-15	6.08e-14
54	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), PIK3CA(33), PIK3R1(33), RAF1(1), RB1(24), TFDP1(1)	8643554	102	87	89	2	7	14	14	17	49	1	5.98e-09	5.44e-15	6.08e-14
55	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PIK3CA(33), PIK3R1(33), PTPN11(4)	5430280	77	69	66	2	9	12	12	17	27	0	3.25e-06	5.55e-15	6.08e-14
56	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), PIK3CA(33), PIK3R1(33), WNT1(1)	13181912	83	72	72	5	10	15	14	16	28	0	2.27e-05	5.77e-15	6.08e-14
57	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(1), ITGB1(1), KLRC1(1), KLRC3(4), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PIK3CA(33), PIK3R1(33), PTK2B(3), PTPN6(1), VAV1(4)	7933038	85	69	74	6	10	12	14	18	31	0	0.000161	5.77e-15	6.08e-14
58	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(2), FOS(1), IGF1(2), IGF1R(3), IRS1(4), MAP2K1(1), MAPK3(1), MAPK8(1), PIK3CA(33), PIK3R1(33), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	10565479	90	77	79	6	8	14	15	23	30	0	4.59e-05	5.88e-15	6.08e-14
59	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), PIK3CA(33), PIK3R1(33), RAF1(1), RALBP1(1), RALGDS(2)	8203069	78	68	67	1	8	13	14	15	28	0	9.60e-08	5.88e-15	6.08e-14
60	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(1), ASAH1(1), BRAF(6), CCL13(1), DAG1(2), EGFR(92), GNA15(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CA(33), PIK3R1(33), PITX2(3), RAF1(1), SRC(2)	22939475	195	137	132	16	25	66	18	53	33	0	9.69e-13	6.00e-15	6.08e-14
61	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EGF(3), EGFR(92)	5473291	95	77	47	11	10	44	2	35	4	0	3.02e-05	6.11e-15	6.08e-14
62	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(2), ATM(4), BRCA1(4), CDKN1A(1), CHEK1(3), CHEK2(1), MAPK8(1), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1), TP53(96)	12725349	119	97	82	7	36	17	14	30	22	0	1.82e-08	6.22e-15	6.08e-14
63	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), PIK3C2G(9), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PTK2B(3), PXN(1), RAF1(1)	11869027	93	80	82	4	15	13	17	18	30	0	3.98e-07	6.22e-15	6.08e-14
64	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(92), ELK1(2), GNB1(1), IGF1R(3), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYC(1), PDGFRA(13), PTPRR(3), RAF1(1), RPS6KA1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1)	14199987	129	102	80	12	16	54	7	43	9	0	1.16e-08	6.44e-15	6.20e-14
65	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PIK3CA(33), PIK3R1(33), PLCG1(6), RPS6KA1(1)	8114269	83	73	72	4	9	16	13	16	29	0	3.60e-06	7.11e-15	6.63e-14
66	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	AKT1(1), CALM1(1), GNB1(1), NFKB1(1), NOS3(3), NPPA(2), PIK3CA(33), PIK3R1(33), SYT1(1)	7722384	76	67	65	1	9	12	12	16	27	0	6.42e-07	7.11e-15	6.63e-14
67	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(2), BTK(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(5), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CA(33), PIK3CG(7), PIK3R1(33), PITX2(3), PTEN(90), ROCK1(2), ROCK2(1), RPS4X(1)	30151577	203	159	175	16	30	43	23	29	78	0	4.55e-11	7.33e-15	6.74e-14
68	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(2), TP53(96)	11724559	108	89	71	2	30	16	13	26	23	0	1.18e-11	8.55e-15	7.74e-14
69	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(2), AKT1(1), ATM(4), BCL2(2), BIRC2(1), BIRC3(1), CAPN1(2), CASP10(1), CASP9(1), CHUK(1), CSF2RB(4), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(2), IRAK2(1), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2), TP53(96)	35873654	226	151	177	21	54	38	29	51	54	0	1.47e-11	1.05e-14	9.42e-14
70	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(2), CAPNS1(1), EGF(3), EGFR(92), ITGA1(2), ITGB1(1), MAPK1(2), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1)	14017404	109	86	61	13	15	45	4	40	5	0	1.53e-06	5.61e-14	4.93e-13
71	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITGB1BP3(1), ITPR1(5), ITPR2(3), ITPR3(5), OCRL(2), PI4KA(1), PI4KB(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PRKCA(1), PRKCG(2), PTEN(90), SYNJ2(3)	53556139	266	180	237	27	54	48	30	50	84	0	5.44e-12	5.95e-14	5.16e-13
72	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(1), CDKN1B(1), CUL1(3), RB1(24), SKP2(1), TFDP1(1), UBE2M(1)	3669052	32	30	30	2	0	1	1	5	24	1	0.0126	6.51e-14	5.57e-13
73	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	EIF2B1(1), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PXN(1)	14587312	97	82	86	9	16	17	14	20	30	0	4.98e-05	7.66e-14	6.46e-13
74	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	MAP3K1(6), MYLK(2), NCF2(2), PAK1(1), PDGFRA(13), PIK3CA(33), PIK3R1(33), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(2), VAV1(4)	14909479	99	80	85	9	8	21	17	22	31	0	6.83e-05	1.01e-13	8.39e-13
75	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYB(1), RB1(24), SP1(1), SP3(1)	2829996	27	26	25	2	0	1	1	2	22	1	0.0550	1.86e-13	1.53e-12
76	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(1), CUL1(3), RB1(24), SKP2(1), TFDP1(1)	3665806	31	30	29	2	0	1	0	6	23	1	0.0202	2.70e-13	2.18e-12
77	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(4), JAK1(2), JAK3(2), MAPK1(2), MAPK3(1), MYC(1), PIK3CA(33), PIK3R1(33), PTPN6(1), RAF1(1), SOCS1(1), SOS1(3), STAT5B(1)	15471747	91	80	80	8	11	13	15	19	33	0	0.000511	3.36e-13	2.68e-12
78	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(1), CUL1(3), FBXW7(1), RB1(24), TFDP1(1)	3546965	30	29	28	2	0	1	0	4	24	1	0.0244	6.54e-13	5.16e-12
79	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), BCL2(2), GSK3B(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), RAF1(1), SOCS1(1), SOS1(3), STAT6(1)	15664308	96	83	85	9	14	14	15	21	32	0	0.000221	1.08e-12	8.41e-12
80	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PIK3CA(33), PIK3R1(33), PXN(1), RAF1(1), ROCK1(2), SRC(2)	15944647	86	74	74	5	9	13	14	20	30	0	2.92e-05	2.17e-12	1.67e-11
81	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(3), EGFR(92), MAP2K1(1), MAPK1(2), MAPK3(1), PTPRB(3), RAF1(1), SOS1(3), SPRY3(2), SRC(2)	10652078	111	91	63	18	13	46	5	41	6	0	0.000282	7.36e-12	5.59e-11
82	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), RB1(24), RBL1(2), TFDP1(1)	6776056	42	40	40	3	0	2	1	9	29	1	0.0111	9.57e-12	7.16e-11
83	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(1), INS(1), INSR(2), IRS1(4), JAK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SOCS1(1), SOS1(3), SRF(1), STAT5B(1)	14085917	96	83	85	10	12	16	16	21	31	0	0.000430	9.65e-12	7.16e-11
84	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CA(33), PIK3R1(33), SYT1(1)	14375138	86	75	75	8	10	15	15	16	30	0	0.000406	2.10e-11	1.54e-10
85	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(1), DAXX(3), EGF(3), EGFR(92), ETS1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), RAF1(1), RIPK1(1), SP1(1), TNFRSF1A(1), TNFRSF1B(1)	20997061	137	107	86	19	22	53	9	42	11	0	8.39e-07	1.90e-10	1.38e-09
86	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(1), ANGPTL2(1), DAG1(2), DGKA(1), GCA(1), ITGA9(2), ITPR1(5), ITPR2(3), ITPR3(5), MAP2K1(1), MAPK1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(3), PDE3B(3), PIK3C2G(9), PIK3CA(33), PIK3R1(33), RIPK3(1), RPS4X(1), VASP(1)	20932390	112	97	101	11	21	23	17	17	34	0	3.82e-06	7.02e-10	5.03e-09
87	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), ASAH1(1), BRAF(6), DAG1(2), DRD2(1), EGFR(92), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CB(4), PITX2(3), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1), TERF2IP(1)	25108064	144	103	92	16	24	59	8	44	9	0	2.56e-09	2.79e-09	1.97e-08
88	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM1(1), ELK1(2), FCER1A(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PIK3CA(33), PIK3R1(33), PLA2G4A(3), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4)	18356741	109	89	96	12	13	23	19	23	31	0	4.80e-05	7.58e-09	5.30e-08
89	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(5), CALM1(1), CAMK1(1), IGF1(2), IGF1R(3), INS(1), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PIK3CA(33), PIK3R1(33), PPP3CB(1), SYT1(1), YWHAH(1)	14890873	92	82	81	11	11	15	16	20	30	0	0.000630	8.30e-09	5.74e-08
90	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), DLD(2), DUSP10(1), DUSP8(1), IL1R1(2), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK7(1), MAPK8(1), NR2C2(1), PAPPA(2), TP53(96), ZAK(3)	21534771	129	101	90	14	36	28	16	29	20	0	4.35e-07	1.02e-08	7.01e-08
91	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BCL2(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), CHUK(1), GZMB(2), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(6), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFSF10(2), TP53(96), TRAF1(1)	24574595	136	106	97	14	40	24	15	31	26	0	4.06e-08	1.24e-08	8.37e-08
92	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), GPX1(1), PRKCE(1)	3363407	29	29	28	4	8	5	5	9	2	0	0.0229	1.51e-08	1.01e-07
93	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	CD36(1), CREBBP(5), EHHADH(1), EP300(1), FABP1(1), HSD17B4(1), INS(1), MAPK1(2), MAPK3(1), ME1(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(2), NFKBIA(1), NR0B2(1), NR1H3(1), NRIP1(2), PIK3CA(33), PIK3R1(33), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(24), RXRA(3), SP1(1), STAT5B(1)	27037883	125	109	112	13	16	17	13	21	57	1	2.59e-05	2.80e-08	1.85e-07
94	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(6), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PIK3CA(33), PIK3R1(33), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4), ZAP70(3)	20406987	109	90	96	11	17	18	19	23	32	0	2.68e-05	5.15e-08	3.37e-07
95	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(6), EGFR(92), ERBB2(1), ERBB4(1), ETS1(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(2), PIWIL3(2), PIWIL4(1), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1)	22440237	129	102	76	17	18	52	8	43	8	0	2.62e-06	1.47e-07	9.51e-07
96	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), PIK3CA(33), SOS1(3)	6991245	42	38	37	4	6	11	8	8	9	0	0.00202	1.52e-07	9.77e-07
97	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), ASAH1(1), BRAF(6), CREB1(1), CREBBP(5), CRKL(1), DAG1(2), EGR1(3), EGR2(2), EGR3(1), ELK1(2), MAP1B(2), MAPK1(2), MAPK3(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NTRK1(1), PIK3C2G(9), PIK3CA(33), PIK3R1(33), PTPN11(4), RPS6KA3(1), SRC(2), TERF2IP(1)	22118519	122	100	107	17	18	20	20	28	36	0	0.000578	4.86e-07	3.09e-06
98	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), BRAF(6), EIF4B(1), FIGF(2), IGF1(2), INS(1), MAPK1(2), MAPK3(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(4), ULK1(1), ULK2(2), VEGFA(2), VEGFB(1), VEGFC(1)	22866738	119	99	104	14	20	22	16	30	31	0	0.000126	2.09e-05	0.000131
99	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(1), AKT1(1), CALM1(1), CAMK1(1), CAMK4(1), CREBBP(5), ELSPBP1(3), F2(2), GATA4(2), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), MYH2(9), NFATC2(2), NFATC4(2), NPPA(2), PIK3CA(33), PIK3R1(33), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1), SYT1(1)	21652037	111	89	100	14	20	16	16	25	34	0	0.000264	2.13e-05	0.000132
100	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(3), GSS(1), GSTA1(2), GSTA4(2), IDH1(14)	7721385	28	28	15	0	19	3	1	4	1	0	4.05e-05	0.000227	0.00140
101	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), IARS(3), IL4R(7), INPP5D(3), JAK1(2), JAK2(2), JAK3(2), NR0B2(1), PIK3CA(33), SOS1(3), SRC(2), STAT6(1), TYK2(3)	15807082	63	56	58	6	17	13	8	16	9	0	0.000322	0.000270	0.00165
102	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(1), IDH1(14), SUCLA2(1)	3779780	16	16	4	0	13	1	0	2	0	0	0.00247	0.000338	0.00204
103	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(3), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), IDH1(14), OPLAH(1)	9384409	31	30	18	0	21	4	1	4	1	0	1.01e-05	0.00168	0.0101
104	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(2), ABL2(2), AKT1(1), AREG(1), BRAF(6), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CDKN1B(1), CRKL(1), EGF(3), EGFR(92), ELK1(2), ERBB2(1), ERBB4(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), MYC(1), NRAS(1), NRG1(2), NRG4(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2), STAT5B(1), TGFA(4)	44152090	244	160	180	33	36	70	23	75	40	0	1.26e-08	0.00503	0.0298
105	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), SRC(2)	5100014	29	28	28	5	8	6	4	9	2	0	0.0552	0.00524	0.0307
106	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3E(2), CD3G(1), CD4(1), CD58(1), CD8A(1), IL3(1), IL6(1), KITLG(1)	2654041	10	10	10	1	3	1	1	3	2	0	0.152	0.00780	0.0453
107	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12B(2)	1274247	6	6	6	1	2	1	1	0	2	0	0.336	0.00786	0.0453
108	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(3), NR0B2(1), NR1H3(1), NR1H4(3), RXRA(3)	2327767	12	12	12	2	5	2	0	4	1	0	0.182	0.00885	0.0505
109	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(2), ATM(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), CHEK2(1), DTX4(2), E2F4(1), E2F6(1), EP300(1), ESPL1(3), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(3), ORC3L(1), ORC5L(1), PRKDC(4), PTPRA(3), RB1(24), RBL1(2), SKP2(1), SMAD4(1), TBC1D8(3), TFDP1(1), TP53(96), WEE1(1)	47281066	196	132	157	24	46	30	16	50	53	1	8.07e-08	0.00924	0.0522
110	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(3), JAK1(2), JAK2(2), STAT1(2)	3484295	12	12	12	0	0	0	3	6	3	0	0.0572	0.0103	0.0576
111	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), EGFR(92), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MAPK8(1), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(3), PTPN11(4), PTPRZ1(3), SRC(2), TJP1(3)	29965010	145	107	97	24	22	55	8	49	11	0	1.28e-05	0.0110	0.0610
112	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(1), AGTR1(1), AGTR2(1), KNG1(2), NOS3(3), REN(5)	4299288	18	18	17	2	10	2	0	2	4	0	0.0401	0.0119	0.0655
113	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(1), ACO1(1), IDH1(14), SUCLA2(1)	5647580	17	17	5	0	13	1	0	2	1	0	0.00175	0.0124	0.0674
114	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(1), UGDH(1), UXS1(2)	1671876	7	7	7	0	1	1	1	2	2	0	0.142	0.0137	0.0741
115	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(2), ANAPC1(2), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC23(2), CDC27(7), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CHEK1(3), CHEK2(1), CREBBP(5), CUL1(3), DBF4(1), EP300(1), ESPL1(3), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), ORC3L(1), ORC5L(1), PRKDC(4), RB1(24), RBL1(2), SFN(1), SKP2(1), SMAD4(1), SMC1A(6), SMC1B(2), TFDP1(1), TP53(96), WEE1(1), YWHAE(2), YWHAH(1)	58359897	226	144	183	28	39	36	22	59	69	1	8.77e-08	0.0144	0.0769
116	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3E(2), CD3G(1), CD4(1)	1368975	6	6	6	1	3	0	1	1	1	0	0.361	0.0157	0.0831
117	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	485067	3	3	3	0	0	0	1	1	1	0	0.420	0.0162	0.0855
118	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	307262	3	3	3	0	2	1	0	0	0	0	0.300	0.0172	0.0898
119	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), LYN(2), MAP2K1(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CA(33), PIK3R1(33), PLCG2(3), RAF1(1), SOS1(3), VAV1(4)	22503688	98	82	87	14	10	22	17	19	30	0	0.00221	0.0181	0.0936
120	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), CASP9(1), KDR(8), KRAS(2), MAP2K1(1), MAPK1(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFATC2(2), NFATC4(2), NOS3(3), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PXN(1), RAF1(1), SRC(2), VEGFA(2)	30965627	137	109	125	21	28	28	15	31	35	0	8.51e-05	0.0201	0.103
121	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(1), LUM(5)	1540941	6	6	5	1	3	0	0	2	1	0	0.398	0.0279	0.142
122	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), CSF2(2), HLA-DRA(1), IL3(1)	1294076	5	5	5	0	2	1	1	0	1	0	0.202	0.0326	0.165
123	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(1), UGDH(1), UXS1(2)	2116868	7	7	7	0	1	1	1	2	2	0	0.143	0.0379	0.190
124	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(1), DLD(2), IDH1(14), IDH3A(1), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2)	8760676	26	25	14	3	15	4	0	7	0	0	0.0121	0.0417	0.207
125	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR109B(2), GPR161(2), GPR34(2), GPR45(3), GPR65(2), GPR68(1), GPR75(1), GPR81(1)	4191191	15	14	15	3	6	2	2	2	3	0	0.115	0.0486	0.240
126	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	CASP10(1), DAXX(3), FAF1(1), LMNB2(1), MAP3K1(6), MAP3K7(3), MAPK8(1), PAK1(1), PRKDC(4), PTPN13(1), RB1(24), SPTAN1(3)	17755230	49	46	45	5	3	9	4	5	27	1	0.00423	0.0602	0.294
127	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(2), ACTN1(2), AKT1(1), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), BRAF(6), CDKN2A(2), CSE1L(1), DOCK1(2), EPHB2(3), FYN(1), GRB7(2), GRLF1(2), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), MAPK1(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(2), P4HB(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CA(33), PIK3CB(4), PKLR(1), PLCG1(6), PLCG2(3), PTEN(90), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SRC(2), TERF2IP(1), TLN2(2), VASP(1), WAS(1), ZYX(2)	52317523	218	157	192	30	32	42	31	46	67	0	4.53e-07	0.0620	0.301
128	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1)	3548618	14	14	14	3	2	3	2	5	2	0	0.268	0.0709	0.341
129	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), CD33(5), CD5(2), CD7(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(2), IL3(1), ITGAX(6), TLR2(4), TLR7(4), TLR9(2)	7905031	36	34	36	8	16	3	3	10	4	0	0.0885	0.0882	0.421
130	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), BTK(1), CSF2(2), FCER1A(2), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(1), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1)	30882079	141	110	128	24	29	26	21	30	35	0	0.000977	0.0898	0.426
131	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(4), ECHS1(1), HADHA(1)	2307207	6	6	6	1	3	2	1	0	0	0	0.268	0.0994	0.467
132	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	CRADD(1), LMNB2(1), MADD(1), MAP3K1(6), MAP3K7(3), MAPK8(1), PAK1(1), PRKDC(4), RB1(24), RIPK1(1), SPTAN1(3), TNFRSF1A(1)	16810408	47	43	43	6	4	7	3	6	26	1	0.0124	0.108	0.502
133	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDK7(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1)	3015338	8	8	8	0	1	2	0	4	1	0	0.183	0.111	0.514
134	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(2), CES1(2)	2576321	8	8	8	1	6	1	0	1	0	0	0.169	0.112	0.516
135	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(1), CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1)	2613761	8	8	8	2	3	2	1	1	1	0	0.347	0.117	0.533
136	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7)	5411801	25	22	25	5	13	0	3	6	3	0	0.0767	0.120	0.541
137	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BRAF(6), CREB1(1), MAPK1(2), RAF1(1), SRC(2), TERF2IP(1)	4837184	14	12	10	2	1	3	2	6	2	0	0.284	0.120	0.541
138	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT2(1), TAT(2), TYR(1)	1997074	7	6	6	0	4	1	2	0	0	0	0.0774	0.129	0.575
139	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), PPARG(1), RETN(1), RXRA(3)	2468069	7	7	7	0	3	1	0	1	2	0	0.110	0.142	0.631
140	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3E(2), CD3G(1), CD4(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(2), STAT4(2), TYK2(3)	6315714	21	19	21	4	12	0	3	3	3	0	0.141	0.145	0.639
141	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2(2), FGA(6), FGB(3), FGG(5), PLAT(3), PLG(2), SERPINB2(1), SERPINE1(2)	5698932	27	25	27	6	7	7	4	8	1	0	0.124	0.147	0.642
142	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(2), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3)	5056039	13	12	13	1	6	2	1	3	1	0	0.0803	0.185	0.801
143	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(3)	4618985	10	10	10	1	3	1	1	3	2	0	0.157	0.186	0.801
144	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(3), SOS1(3), SRC(2)	3765735	9	9	9	1	2	1	1	3	2	0	0.249	0.189	0.810
145	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNA2(1), CCNE1(1), CCNE2(1), CDKN1B(1), CDKN2A(2), E2F4(1), PRB1(1)	3789140	9	9	9	1	1	0	1	5	2	0	0.298	0.206	0.877
146	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PSAT1(2)	2060612	6	5	5	1	4	2	0	0	0	0	0.225	0.214	0.905
147	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(1)	1016477	3	3	3	0	3	0	0	0	0	0	0.329	0.252	1.000
148	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(4), LNPEP(2), MME(1), REN(5)	9037214	28	27	27	5	12	4	1	5	6	0	0.0627	0.263	1.000
149	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(2), TGFBR2(2), TGFBR3(1)	4528454	11	11	11	2	1	3	3	2	2	0	0.183	0.285	1.000
150	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS1(1), PTGS2(1)	2260557	7	7	7	2	1	2	0	1	3	0	0.499	0.289	1.000
151	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1), TAT(2)	1116311	3	3	2	0	2	1	0	0	0	0	0.315	0.295	1.000
152	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1)	3538159	8	8	8	0	2	1	2	1	2	0	0.116	0.296	1.000
153	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(2), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1)	10250831	23	22	23	2	5	4	2	10	2	0	0.0368	0.299	1.000
154	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(2), F5(6), FGA(6), FGB(3), FGG(5), PROS1(2), SERPINC1(1)	6968463	26	26	26	6	6	7	4	6	3	0	0.129	0.301	1.000
155	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1)	2064312	4	4	4	1	0	3	0	0	1	0	0.424	0.312	1.000
156	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUL(1), HAL(2)	8086789	16	15	16	1	6	3	2	3	2	0	0.0287	0.318	1.000
157	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM1(1), CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1)	12165786	34	30	32	5	9	7	6	6	6	0	0.0188	0.323	1.000
158	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(2), IFNGR1(1), JAK1(2), JAK2(2), PTPRU(1), STAT1(2)	4889683	10	10	10	1	1	0	1	5	3	0	0.273	0.324	1.000
159	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), BCL2(2), BTK(1), CD19(1), CD22(6), CR2(4), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(2), NR0B2(1), PIK3CA(33), PIK3R1(33), PLCG2(3), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(4)	31703806	126	98	115	21	28	23	17	22	36	0	0.000762	0.345	1.000
160	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), F2RL3(2), GNB1(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1)	10399846	22	20	22	1	8	4	2	6	2	0	0.00775	0.347	1.000
161	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(7), JAK1(2), JAK2(2), TYK2(3)	4463567	15	15	15	4	6	1	0	6	2	0	0.458	0.352	1.000
162	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(7), JAK1(2), JAK2(2), TYK2(3)	4463567	15	15	15	4	6	1	0	6	2	0	0.458	0.352	1.000
163	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(3), APOBEC2(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1)	3109761	8	8	8	2	4	1	2	1	0	0	0.420	0.359	1.000
164	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP54(2), SRPR(2)	3196895	6	6	6	0	1	1	2	1	1	0	0.153	0.363	1.000
165	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	773363	2	2	2	0	1	1	0	0	0	0	0.440	0.370	1.000
166	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), DAXX(3), DDIT3(1), ELK1(2), MAP3K1(6), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPKAPK2(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), PLA2G4A(3), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(2)	15687691	36	33	34	4	7	12	5	8	4	0	0.00463	0.381	1.000
167	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(2)	2007724	5	5	4	2	2	0	0	1	2	0	0.892	0.391	1.000
168	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	855793	1	1	1	0	1	0	0	0	0	0	0.782	0.399	1.000
169	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), GOT2(1), PAH(2), TAT(2)	3521337	7	7	6	1	4	1	0	2	0	0	0.329	0.408	1.000
170	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	5731879	14	14	14	3	4	1	1	3	5	0	0.214	0.445	1.000
171	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(1), CTH(1), MUT(1)	2091469	4	4	4	1	1	0	1	2	0	0	0.612	0.447	1.000
172	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2)	1372644	2	2	2	0	1	0	1	0	0	0	0.486	0.450	1.000
173	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(1), LDLR(3)	2267298	5	5	5	2	0	1	0	4	0	0	0.776	0.451	1.000
174	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(3)	2864997	11	10	11	3	5	1	1	2	2	0	0.350	0.453	1.000
175	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH1C(2)	2392708	6	5	6	2	2	0	0	4	0	0	0.641	0.472	1.000
176	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(2), CALM1(1), CAMK2A(1), CLCA1(2), CLCA2(1), CLCA4(1), CNGA4(3), CNGB1(3), GUCA1C(1), PDC(1), PDE1C(4), PRKG1(1), PRKG2(5), PRKX(1)	13011425	30	29	30	4	13	6	5	3	3	0	0.0155	0.474	1.000
177	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1)	3390836	8	8	8	2	1	3	1	2	1	0	0.382	0.477	1.000
178	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2)	1653000	3	3	3	1	2	1	0	0	0	0	0.573	0.482	1.000
179	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), CCND2(2), CDKN1B(1), CEBPB(1), EGR1(3), ESR2(3), FSHR(1), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(2), PGR(5), ZP2(2)	14958597	29	28	29	3	4	8	3	10	4	0	0.0289	0.483	1.000
180	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI2(1)	1830020	3	3	3	0	1	0	1	1	0	0	0.407	0.486	1.000
181	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	700460	1	1	1	0	0	0	1	0	0	0	0.685	0.486	1.000
182	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F13B(1), F2(2), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), LPA(4), PLAT(3), PLG(2), SERPINB2(1), SERPINE1(2), VWF(7)	15030817	53	46	53	11	16	12	5	13	7	0	0.0187	0.502	1.000
183	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1)	2274539	6	6	6	2	4	0	0	1	1	0	0.591	0.516	1.000
184	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BCL2(2), CASP8AP2(1), CASP9(1), CES1(2)	4783595	7	7	7	1	2	1	0	1	3	0	0.563	0.554	1.000
185	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUD2(3), GLUL(1), HAL(2)	9050329	19	17	19	2	8	3	2	4	2	0	0.0410	0.564	1.000
186	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CSK(1), PRKCA(1), PTPRA(3), SRC(2)	3925602	7	7	7	0	3	3	0	1	0	0	0.0572	0.565	1.000
187	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(1), ACO1(1), CLYBL(4), DLD(2), IDH1(14), IDH3A(1), OGDH(3), OGDHL(3), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2)	12684021	37	34	23	7	16	4	1	12	4	0	0.0809	0.566	1.000
188	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CHEK1(3), WEE1(1), YWHAH(1)	5871476	9	9	9	0	1	0	3	3	2	0	0.135	0.569	1.000
189	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), CALM1(1), CHRM1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PDE2A(1), PDE3A(3), PDE3B(3), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(5), RYR2(30), SLC7A1(1), SYT1(1)	17520286	68	61	68	15	30	13	9	11	5	0	0.00634	0.589	1.000
190	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2)	1642043	2	2	2	0	0	0	0	0	2	0	1.000	0.594	1.000
191	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1)	5063875	8	8	8	0	2	3	0	1	2	0	0.0653	0.602	1.000
192	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPO(1), FOS(1), JAK2(2), MAP2K1(1), MAPK3(1), MAPK8(1), PLCG1(6), PTPN6(1), RAF1(1), SOS1(3), STAT5B(1)	9193005	21	20	21	4	5	2	3	8	3	0	0.225	0.607	1.000
193	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1)	3398468	5	5	5	1	0	1	1	3	0	0	0.496	0.608	1.000
194	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), MAOA(1), MAOB(2), PRPS2(2)	10430725	30	25	30	4	18	3	1	8	0	0	0.0107	0.612	1.000
195	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1)	8782649	19	18	17	4	5	5	3	2	4	0	0.175	0.640	1.000
196	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), FOS(1), IL3(1), IL3RA(2), JAK2(2), MAP2K1(1), MAPK3(1), PTPN6(1), RAF1(1), SOS1(3), STAT5B(1)	7526802	18	18	17	4	7	1	2	5	3	0	0.355	0.645	1.000
197	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1)	1660630	2	2	2	1	0	0	1	1	0	0	0.841	0.649	1.000
198	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	897086	1	1	1	0	0	1	0	0	0	0	0.642	0.653	1.000
199	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(3), KARS(2)	2958690	7	7	5	3	2	0	0	2	3	0	0.945	0.657	1.000
200	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), JAK2(2), MAPK8(1), STAT4(2), TYK2(3)	7991741	23	21	23	5	11	0	4	5	3	0	0.177	0.661	1.000
201	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), GAMT(1), GATM(2), NAGS(1), OTC(3)	7509141	18	18	17	4	6	2	4	6	0	0	0.279	0.664	1.000
202	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(2), TPO(4), TYR(1)	4136839	9	9	9	2	6	0	1	1	1	0	0.344	0.664	1.000
203	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(1), TGM2(1)	2139700	5	5	5	2	2	0	0	3	0	0	0.689	0.669	1.000
204	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2843048	7	7	7	2	4	0	3	0	0	0	0.510	0.675	1.000
205	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2843048	7	7	7	2	4	0	3	0	0	0	0.510	0.675	1.000
206	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(3), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3)	19211046	83	71	77	17	21	14	12	19	17	0	0.0334	0.693	1.000
207	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), PTPRU(1), STAT1(2), STAT2(1), TYK2(3)	5344392	10	10	10	2	4	0	1	3	2	0	0.352	0.701	1.000
208	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), MPO(2), TPO(4)	3591574	8	8	8	2	6	0	0	1	1	0	0.423	0.701	1.000
209	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), FECH(1), HMBS(1), PPOX(1)	3244234	4	4	4	0	0	1	1	1	1	0	0.296	0.712	1.000
210	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CD28(1), CD4(1), CSF2(2), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7)	8571347	30	26	30	8	14	0	4	7	5	0	0.183	0.713	1.000
211	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3)	3853164	11	11	11	4	6	0	2	2	1	0	0.591	0.730	1.000
212	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(1), SOAT1(3)	5935037	12	11	12	2	3	2	0	5	2	0	0.332	0.734	1.000
213	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CTH(1), GOT2(1), LDHAL6A(1), LDHAL6B(1), SULT1B1(7)	5332113	11	10	11	3	0	3	1	6	1	0	0.543	0.739	1.000
214	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(1), PC(2), PDHA1(1), SLC25A11(1)	3944319	6	6	6	1	1	1	0	3	1	0	0.464	0.740	1.000
215	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHST13(1), CHSY1(2), DSE(3), UST(1), XYLT1(1), XYLT2(2)	5993668	11	11	11	1	4	2	1	2	2	0	0.0507	0.744	1.000
216	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(3)	1925908	4	4	4	2	2	0	0	2	0	0	0.828	0.744	1.000
217	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1)	3514387	4	4	4	1	2	0	0	1	1	0	0.687	0.745	1.000
218	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(4), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2)	8745016	20	18	20	4	6	4	1	7	2	0	0.118	0.747	1.000
219	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ECHS1(1), EHHADH(1), HADHA(1)	3553336	4	4	4	1	0	3	0	0	1	0	0.479	0.754	1.000
220	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADHA(1), HSD17B4(1), MECR(1)	3626548	4	4	4	0	0	2	0	1	1	0	0.300	0.755	1.000
221	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNB1(1), HTR2C(1), PLCB1(1)	3048016	4	4	4	1	1	1	0	1	1	0	0.668	0.755	1.000
222	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2)	3412217	6	6	6	2	4	1	0	1	0	0	0.458	0.756	1.000
223	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2)	3412217	6	6	6	2	4	1	0	1	0	0	0.458	0.756	1.000
224	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT2(1), PAH(2), TAT(2), YARS2(1)	3711919	7	7	6	2	3	2	0	2	0	0	0.506	0.760	1.000
225	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1)	6602948	11	11	11	2	3	1	2	2	3	0	0.365	0.767	1.000
226	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(2), JAK2(2), JAK3(2), PIAS3(1), PTPRU(1), SRC(2), STAT3(1)	6565772	12	12	12	2	3	3	0	5	1	0	0.257	0.778	1.000
227	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(4), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1)	7168051	12	11	12	2	5	2	2	1	2	0	0.150	0.778	1.000
228	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH3A1(2), MIOX(1), UGDH(1)	3649663	5	5	5	1	3	0	0	1	1	0	0.499	0.790	1.000
229	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2)	2609295	3	3	3	0	1	1	1	0	0	0	0.295	0.805	1.000
230	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1), ST3GAL1(1)	5331705	10	9	10	1	6	1	1	1	1	0	0.108	0.806	1.000
231	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1)	4340297	6	6	6	1	2	1	0	3	0	0	0.368	0.809	1.000
232	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST6GALNAC4(1), ST8SIA1(1)	2405823	3	3	3	1	1	0	0	1	1	0	0.690	0.809	1.000
233	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(3), ALPPL2(4)	2813061	8	7	8	3	5	1	1	0	1	0	0.468	0.812	1.000
234	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(5), GLS(1)	3310117	6	5	6	2	2	0	2	2	0	0	0.668	0.819	1.000
235	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1)	4774107	6	6	6	0	2	0	2	1	1	0	0.195	0.820	1.000
236	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(2), HK3(2), PGM1(1), TGDS(1)	4360429	6	6	6	1	4	1	0	1	0	0	0.316	0.821	1.000
237	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(2), B4GALT2(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1)	6886786	16	16	16	4	7	2	1	4	2	0	0.333	0.830	1.000
238	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA5(1), PSMB8(2)	3713515	4	4	4	0	1	2	1	0	0	0	0.207	0.830	1.000
239	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), MPO(2), MTHFR(1), TPO(4)	4969496	9	9	9	2	6	0	1	1	1	0	0.368	0.834	1.000
240	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(2)	6308479	9	9	9	0	4	2	1	1	1	0	0.0370	0.839	1.000
241	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2)	4642632	11	11	11	7	0	3	1	2	5	0	0.955	0.840	1.000
242	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(7), MCAT(1), OXSM(1)	6823670	14	14	14	3	7	2	1	3	1	0	0.230	0.847	1.000
243	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), DDC(3), EPX(2), GOT2(1), MAOA(1), MAOB(2), MPO(2), TAT(2), TPO(4)	9404708	27	25	26	5	17	2	1	6	1	0	0.0466	0.848	1.000
244	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(1), GGT1(1)	2460682	2	2	2	0	0	2	0	0	0	0	0.374	0.853	1.000
245	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(1)	2729412	3	3	3	0	2	0	0	1	0	0	0.360	0.854	1.000
246	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1385310	1	1	1	0	0	1	0	0	0	0	0.565	0.855	1.000
247	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNB1(1)	2821093	4	4	4	0	2	1	0	1	0	0	0.269	0.858	1.000
248	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP2(1), BMP4(1), BMP5(4), BMP6(1), BTRC(1), CSNK1D(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(3), GLI3(1), GSK3B(1), HHIP(1), IHH(1), LRP2(17), PRKX(1), PTCH2(2), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	26050948	64	58	64	9	31	8	6	10	9	0	0.000686	0.859	1.000
249	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(2), GSK3B(1)	4927815	7	7	7	2	0	1	2	2	2	0	0.630	0.859	1.000
250	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	3613886	4	4	4	1	1	0	1	2	0	0	0.589	0.859	1.000
251	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT3(2), FUT5(3), FUT6(1)	2181989	7	7	7	3	4	0	0	3	0	0	0.653	0.862	1.000
252	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	GLS(1), PRODH(1)	2370899	2	2	2	1	1	0	0	1	0	0	0.804	0.868	1.000
253	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IKBKB(1), IL12B(2), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(2), TLR1(2), TLR2(4), TLR3(1), TLR5(2), TLR6(5), TLR7(4), TLR8(1), TLR9(2)	38300578	147	106	136	29	35	28	17	30	37	0	0.00177	0.870	1.000
254	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPT(2), ENPP1(1), TYR(1)	4129992	4	4	4	0	2	0	1	1	0	0	0.301	0.872	1.000
255	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3E(2), CD3G(1), GZMB(2), ICAM1(1), ITGB2(5)	3720925	12	12	12	6	4	0	2	2	4	0	0.716	0.873	1.000
256	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(2), ACPT(2), ENPP1(1), LHPP(1), MTMR1(2), TYR(1)	6400716	9	9	9	2	5	1	2	1	0	0	0.353	0.875	1.000
257	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPO(1), JAK2(2), NFKB1(1), NFKBIA(1)	5420175	6	6	6	0	2	1	0	3	0	0	0.175	0.876	1.000
258	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(1), XDH(3)	4266617	6	6	6	2	2	1	0	3	0	0	0.616	0.879	1.000
259	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ECHS1(1), EHHADH(1), HADHA(1)	5189816	9	9	9	3	4	3	0	1	1	0	0.359	0.882	1.000
260	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), TAX1BP3(1), UBE2E3(1), UBE2M(1), UBE3A(1)	4487801	5	5	5	1	2	1	1	0	1	0	0.325	0.886	1.000
261	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), GZMB(2), SCAP(1), SREBF1(1), SREBF2(1)	7838168	9	9	9	1	2	1	2	3	1	0	0.203	0.886	1.000
262	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA4(1), NDUFS2(1)	2982815	3	3	3	1	0	1	0	1	1	0	0.723	0.886	1.000
263	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(1)	1694665	3	3	3	2	3	0	0	0	0	0	0.800	0.888	1.000
264	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PIK3C2G(9), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1)	10810365	20	20	20	4	7	3	5	2	3	0	0.185	0.891	1.000
265	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	1800326	1	1	1	0	0	1	0	0	0	0	0.585	0.892	1.000
266	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(3), CYP11B2(2), HSD11B1(2)	2936185	9	9	9	4	5	3	0	0	1	0	0.545	0.893	1.000
267	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(5), ACACB(7), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2)	16891266	30	28	30	4	11	7	2	8	2	0	0.0245	0.903	1.000
268	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT2(1)	2902973	2	2	2	0	0	1	0	1	0	0	0.539	0.904	1.000
269	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(10), ABCB11(2), ABCB4(6), ABCC1(1), ABCC3(1)	6113021	20	20	20	7	7	4	1	4	4	0	0.390	0.906	1.000
270	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(4), ALDH1A3(1), ALDH3A1(2), AOC2(2), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HIBCH(1), MLYCD(1)	11523583	20	19	20	3	8	5	0	6	1	0	0.0461	0.907	1.000
271	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(1), RANGAP1(2)	3577698	3	3	3	0	1	0	0	1	1	0	0.404	0.909	1.000
272	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	BCL2(2), CASP9(1), DAXX(3), IL1A(1), MAPKAPK2(1), MAPKAPK3(1)	4841152	9	8	9	3	1	3	1	2	2	0	0.603	0.910	1.000
273	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT8(1)	6046425	10	10	9	2	4	2	0	2	2	0	0.302	0.910	1.000
274	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), CSNK1D(1), GSK3B(1)	4013083	6	6	6	2	1	2	1	2	0	0	0.515	0.914	1.000
275	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), PPP1R1B(1)	1629737	2	2	2	2	2	0	0	0	0	0	0.834	0.917	1.000
276	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1)	5497217	8	8	8	2	3	1	0	2	2	0	0.506	0.918	1.000
277	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(4), CRY1(1), PER1(1)	3656666	6	6	5	3	1	1	0	1	3	0	0.942	0.919	1.000
278	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2)	5674294	9	8	9	3	4	0	0	5	0	0	0.564	0.919	1.000
279	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(3), GLI3(1), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1)	7156191	11	10	11	2	4	1	1	3	2	0	0.306	0.920	1.000
280	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(2), HK3(2), PGM1(1), TGDS(1)	4988978	6	6	6	1	4	1	0	1	0	0	0.301	0.923	1.000
281	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FSHR(1)	4085035	4	4	4	0	2	2	0	0	0	0	0.225	0.924	1.000
282	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(4), AGXT(1), AKR1B10(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(2), PSPH(5), SARDH(1), SARS2(1), TARS(1), TARS2(1)	18352850	42	40	40	7	14	10	1	13	4	0	0.0250	0.926	1.000
283	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(2), MST1R(2)	2805740	6	6	6	3	1	0	1	2	2	0	0.871	0.926	1.000
284	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(4), LCT(3), NEU1(1), NEU2(3), NEU4(2)	7100038	13	11	13	3	4	4	1	3	1	0	0.222	0.926	1.000
285	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG5(1), ATG7(1), IFNA10(2), IFNA21(1), IFNG(2), INS(1), ULK1(1), ULK2(2)	9002789	13	12	13	3	1	3	2	3	4	0	0.310	0.926	1.000
286	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(2), MPO(2), TPO(4)	5060471	8	8	8	2	6	0	0	1	1	0	0.404	0.927	1.000
287	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1)	5603143	7	7	7	0	4	1	0	2	0	0	0.104	0.929	1.000
288	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1)	7734438	8	7	8	0	0	1	2	2	3	0	0.211	0.931	1.000
289	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCL2(1), CCR5(1), FOS(1), MAPK8(1), PLCG1(6), PRKCA(1), PTK2B(3), SYT1(1)	5858813	16	15	16	5	5	1	2	5	3	0	0.422	0.934	1.000
290	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	OGDH(3), SUCLA2(1)	3990960	4	4	2	3	0	1	0	0	3	0	0.988	0.935	1.000
291	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX5(1), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1)	10174517	23	22	23	5	9	3	2	8	1	0	0.182	0.937	1.000
292	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B3(1), HSD17B4(1)	3443346	3	3	3	2	0	2	0	0	1	0	0.812	0.938	1.000
293	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(1), LEPR(1), PRKAG2(1)	6157138	8	8	8	2	4	0	0	2	2	0	0.596	0.939	1.000
294	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), FUT8(1), ST3GAL1(1)	3354914	3	3	3	0	1	0	0	1	1	0	0.422	0.939	1.000
295	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), GNB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1), SRC(2)	8796150	12	12	12	1	5	3	1	3	0	0	0.0641	0.940	1.000
296	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(1), ECHS1(1), EHHADH(1), HADHA(1)	3326788	4	4	4	2	0	3	0	0	1	0	0.720	0.940	1.000
297	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1)	7754009	12	11	10	3	2	5	1	3	1	0	0.302	0.942	1.000
298	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), PDE6A(2), PDE6B(2), SLC6A13(2)	15386356	22	22	22	2	13	6	1	0	2	0	0.00249	0.943	1.000
299	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HK2(2), HK3(2), RENBP(2)	7211376	8	8	8	1	4	0	1	1	2	0	0.269	0.949	1.000
300	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), MVD(1), MVK(1)	5673256	5	5	5	0	2	0	2	1	0	0	0.190	0.950	1.000
301	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), MAPK1(2), MAPK8(1), PRKCA(1)	3801656	6	6	6	3	1	1	1	2	1	0	0.844	0.953	1.000
302	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1)	2401280	1	1	1	0	0	1	0	0	0	0	0.600	0.954	1.000
303	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(2), FYN(1), ITGA1(2), ITGB1(1), L1CAM(5), LYN(2), SELP(2)	6719107	16	16	16	5	7	2	5	2	0	0	0.384	0.955	1.000
304	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(2), ACPT(2), ALPI(1), ALPP(3), ALPPL2(4), CYP3A4(2), CYP3A43(1), CYP3A5(5), PON1(2)	7682859	22	21	22	7	12	2	3	4	1	0	0.320	0.957	1.000
305	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	GZMB(2)	4046589	2	2	2	1	0	0	1	0	1	0	0.804	0.958	1.000
306	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2)	2730500	3	3	3	2	2	0	1	0	0	0	0.871	0.959	1.000
307	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2)	6196189	10	10	9	4	4	2	2	2	0	0	0.526	0.960	1.000
308	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB1(1), DUSP10(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAPK1(2), MAPK13(1), MAPKAPK2(1), NFKB1(1), NR2C2(1), SRF(1)	14288568	24	22	24	4	6	8	5	2	3	0	0.0559	0.960	1.000
309	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(1), PRKCA(1), PSEN1(1)	3823486	3	3	3	0	1	0	0	2	0	0	0.479	0.961	1.000
310	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3)	10925639	38	36	38	10	26	5	2	5	0	0	0.0157	0.961	1.000
311	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), STAT6(1)	6368796	17	17	17	5	6	2	1	4	4	0	0.459	0.962	1.000
312	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDK7(1), SHH(2)	3719269	3	2	3	0	2	1	0	0	0	0	0.306	0.963	1.000
313	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNB1(1), PRKAG2(1), PRKAR1B(1), PRKAR2B(1)	6565638	7	7	7	0	3	1	0	3	0	0	0.130	0.966	1.000
314	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(2), APC(1), AXIN1(3), AXIN2(1), DACT1(1), DKK1(1), DKK2(3), DVL1(1), FSTL1(1), GSK3B(1), LRP1(9), MVP(3), NKD1(1), PSEN1(1), PTPRA(3), WIF1(1)	17339231	34	31	34	5	13	3	5	8	5	0	0.0255	0.967	1.000
315	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(1)	2990378	9	9	9	5	5	1	1	0	2	0	0.681	0.968	1.000
316	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNB1(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1)	4114523	4	4	4	1	2	0	0	2	0	0	0.658	0.968	1.000
317	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), GCNT2(1), ST8SIA1(1)	2627578	3	3	3	2	2	0	0	0	1	0	0.880	0.968	1.000
318	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), STX5(1), STX6(1), STX7(1), TSNARE1(2), USE1(1), VAMP3(1), VAMP5(1), VAMP7(3)	7179054	12	12	12	3	3	0	3	4	2	0	0.509	0.969	1.000
319	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGB2(5), PTPRC(2)	4568271	14	14	14	9	7	0	1	3	3	0	0.867	0.970	1.000
320	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK2(1), IRAK3(3), MAP2K3(3), MAP3K1(6), MAP3K7(3), MAPK8(1), NFKB1(1), NFKBIA(1)	12673247	32	30	30	8	7	10	3	7	5	0	0.109	0.971	1.000
321	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3)	5803164	7	7	7	2	2	1	1	1	2	0	0.600	0.973	1.000
322	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C8B(4), C9(2)	8952695	21	21	21	6	7	4	1	5	4	0	0.323	0.973	1.000
323	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), SCAP(1), SREBF1(1), SREBF2(1)	5147240	6	6	6	2	1	2	0	3	0	0	0.591	0.974	1.000
324	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), CD4(1), ICAM1(1), ITGB2(5), PTPRC(2)	4797365	14	14	14	9	7	0	1	3	3	0	0.873	0.974	1.000
325	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1)	5428864	6	6	6	2	1	0	2	3	0	0	0.630	0.974	1.000
326	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), PDHA1(1), PDHA2(3)	4272955	7	7	7	3	2	3	0	1	1	0	0.687	0.976	1.000
327	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(3), SRC(2)	12169120	16	15	16	1	6	1	1	7	1	0	0.0569	0.976	1.000
328	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	OXCT2(1)	3077197	1	1	1	1	1	0	0	0	0	0	0.906	0.976	1.000
329	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(5), GZMB(2)	4522340	7	7	7	3	1	1	2	0	3	0	0.683	0.978	1.000
330	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), GZMB(2), LMNB2(1)	8256672	9	9	9	2	1	1	3	2	2	0	0.390	0.978	1.000
331	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2)	14139319	20	19	20	3	3	4	7	6	0	0	0.0819	0.978	1.000
332	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST13(1), SULT2B1(1), SUOX(1)	3929266	3	3	3	0	1	1	0	1	0	0	0.348	0.979	1.000
333	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6422045	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
334	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6422045	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
335	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6422045	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
336	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CALM1(1), CREB1(1), ELK1(2), FOS(1), GNB1(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1), SYT1(1)	14951936	28	27	28	5	9	4	3	7	5	0	0.0766	0.980	1.000
337	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1)	5275274	8	7	8	3	2	2	0	3	1	0	0.686	0.981	1.000
338	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1)	5688319	6	6	6	2	1	0	2	3	0	0	0.629	0.982	1.000
339	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SUOX(1)	2584800	1	1	1	0	0	0	0	1	0	0	0.837	0.982	1.000
340	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(2), HARS(2), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1)	13634278	18	18	18	3	3	3	3	7	2	0	0.273	0.982	1.000
341	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2)	3981788	12	12	12	5	5	3	0	2	2	0	0.680	0.983	1.000
342	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2)	3981788	12	12	12	5	5	3	0	2	2	0	0.680	0.983	1.000
343	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(1), EGR2(2), EGR3(1), MAP3K1(6), MYC(1), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), SYT1(1), VIPR2(1)	11923852	27	24	25	7	6	6	4	6	5	0	0.170	0.983	1.000
344	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(1), C6(1), C8A(2), C9(2)	5397584	12	12	12	6	3	1	1	4	3	0	0.839	0.984	1.000
345	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1), SYT1(1)	4962963	7	7	7	4	2	0	1	1	3	0	0.883	0.984	1.000
346	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), F10(1), F2(2), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(1)	19098511	58	52	58	15	12	16	8	14	8	0	0.0777	0.985	1.000
347	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), AXIN1(3), BMP2(1), BMP4(1), BMP5(4), BMPR2(1), CHRD(2), DVL1(1), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(3), NPPA(2), RFC1(1), TGFBR1(2), TGFBR2(2), TGFBR3(1), WNT1(1)	15593078	30	26	30	5	6	6	5	9	4	0	0.0594	0.985	1.000
348	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(1), NCL(1)	3804800	4	4	4	2	2	0	1	0	1	0	0.795	0.985	1.000
349	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(2), DPYS(1), ENPP1(1)	5947272	4	4	4	1	0	0	0	4	0	0	0.741	0.986	1.000
350	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(1), CBR1(2), CYP4F2(3), CYP4F3(2), EPX(2), GGT1(1), MPO(2), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4)	11919927	27	26	27	6	16	2	0	6	3	0	0.112	0.987	1.000
351	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	6448280	11	10	11	3	5	2	0	2	2	0	0.289	0.987	1.000
352	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6835579	11	11	11	4	4	2	1	4	0	0	0.585	0.988	1.000
353	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1)	5803086	5	5	5	2	0	0	1	2	2	0	0.928	0.990	1.000
354	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), CHUK(1), CRADD(1), DAXX(3), GSN(1), LMNB2(1), MAP3K1(6), MAP3K5(1), MAPK8(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(4), PRKCD(3), PRKDC(4), PSEN1(1), RB1(24), RIPK1(1), SPTAN1(3), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	29843277	67	63	62	11	10	7	6	12	31	1	0.0193	0.990	1.000
355	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), DDX20(1), E2F4(1), ETS1(2), FOS(1), HDAC2(3), NCOR2(2), RBL1(2), SIN3A(2)	11215733	15	14	15	2	3	3	1	5	3	0	0.206	0.990	1.000
356	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	3458549	1	1	1	1	0	0	0	0	1	0	1.000	0.991	1.000
357	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), SYT1(1), YWHAH(1)	8685469	11	11	11	3	2	2	2	3	2	0	0.412	0.991	1.000
358	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(1), HDC(3), TPH1(2)	2594909	7	7	7	4	4	1	0	2	0	0	0.744	0.991	1.000
359	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), XDH(3)	3388474	6	6	6	5	2	2	0	1	1	0	0.884	0.992	1.000
360	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1)	9991564	8	8	8	1	2	3	2	0	1	0	0.186	0.992	1.000
361	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1)	13745288	32	29	30	8	9	8	6	7	2	0	0.120	0.992	1.000
362	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1)	4731723	11	11	11	6	3	3	0	3	2	0	0.838	0.993	1.000
363	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(1), FDPS(2), IDI2(1), MVD(1), MVK(1), NQO1(1)	8291757	8	8	8	2	2	1	2	2	1	0	0.560	0.993	1.000
364	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(2), GAPDH(1), INS(1), INSR(2), ITCH(1), MAGI1(2), MAGI2(2), RERE(5), WWP2(1)	10239420	20	18	20	5	3	6	2	5	4	0	0.374	0.993	1.000
365	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACADS(4), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(2), PCCB(1)	18365184	28	27	27	5	13	7	4	2	2	0	0.0319	0.993	1.000
366	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	10453595	21	20	19	6	4	9	2	4	2	0	0.256	0.993	1.000
367	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(1), NCOA1(1), NCOA2(3), PPARG(1), RXRA(3)	7873022	14	14	14	5	4	2	1	2	5	0	0.605	0.994	1.000
368	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	NCOA1(1), NCOA2(3), NCOR2(2), POLR2A(2), RXRA(3), TBP(2)	10714543	13	13	13	3	2	2	0	3	6	0	0.443	0.994	1.000
369	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), SP1(1), SP3(1), SYT1(1)	8927148	17	16	17	5	4	4	2	4	3	0	0.308	0.995	1.000
370	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), DDC(3), EPX(2), ESCO1(1), GOT2(1), MAOA(1), MAOB(2), MPO(2), MYST4(1), TAT(2), TPO(4)	14604157	29	26	28	5	17	4	1	6	1	0	0.0318	0.995	1.000
371	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(2), IL12B(2), IL16(1), IL1A(1), IL3(1), IL6(1)	4211242	9	9	9	5	2	2	1	3	1	0	0.749	0.995	1.000
372	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), SOS1(3), SRC(2), ZYX(2)	20168500	29	24	29	3	7	5	6	8	3	0	0.0152	0.996	1.000
373	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(5), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9833975	22	22	22	6	10	3	2	4	3	0	0.304	0.996	1.000
374	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(5), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9833975	22	22	22	6	10	3	2	4	3	0	0.304	0.996	1.000
375	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(5), EP300(1), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(3), NFKB1(1), NFKBIA(1), TGFBR1(2), TGFBR2(2), TLR2(4)	12662324	25	23	25	6	6	7	3	3	6	0	0.147	0.996	1.000
376	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(2), RECK(1), TIMP3(1)	3205011	4	4	4	3	2	0	0	2	0	0	0.877	0.996	1.000
377	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(1), CAMK2A(1), F2(2), FYN(1), GNB1(1), JAK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), STAT1(2), STAT3(1), SYT1(1)	17819483	35	30	35	7	7	4	6	12	6	0	0.0780	0.996	1.000
378	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(3), CASP1(2), CASP10(1), CASP9(1), GZMB(2)	5481874	9	9	8	5	1	1	1	4	2	0	0.861	0.996	1.000
379	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(1)	5205473	8	8	8	4	1	2	0	3	2	0	0.744	0.996	1.000
380	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(3), PDHA1(1), PDHA2(3), VARS(1), VARS2(2)	7951047	10	10	10	3	2	3	2	2	1	0	0.461	0.996	1.000
381	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(4), ADC(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(2), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(2), NAGS(1), OTC(3)	12634407	28	27	28	8	10	3	4	10	1	0	0.356	0.996	1.000
382	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), PSEN1(1)	4047818	2	2	2	1	0	0	0	1	1	0	0.931	0.996	1.000
383	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), CARM1(3), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), PRMT8(1), PRPS2(2), UROC1(1)	16959699	36	32	35	6	20	4	1	10	1	0	0.0159	0.996	1.000
384	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(1), GALNT6(1), GALNT7(1), GALNT9(2), GCNT1(2), ST3GAL1(1), WBSCR17(7)	6130441	16	16	16	7	6	3	1	3	3	0	0.743	0.997	1.000
385	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), CYP11A1(3), HPGD(1), HSD11B1(2), PLA2G4A(3), PTGER4(1), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	8810572	17	17	17	5	7	2	0	4	4	0	0.344	0.997	1.000
386	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), CALM1(1), EPS15(2), PICALM(1), PPP3CB(1), SYNJ2(3), SYT1(1)	9299851	13	13	13	4	7	0	2	2	2	0	0.366	0.997	1.000
387	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(2), IL1A(1), IL3(1), IL6(1), IL7(1)	5691635	13	13	13	6	4	3	2	2	2	0	0.622	0.997	1.000
388	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), PDHA1(1), PDHA2(3)	10993065	21	21	21	7	9	6	1	2	3	0	0.288	0.997	1.000
389	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN3(1), CSK(1), CTNNA1(2), CTNNA2(2), PXN(1), SRC(2)	8184372	11	10	11	3	2	3	1	4	1	0	0.495	0.997	1.000
390	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2)	7553446	17	17	17	6	6	2	1	5	3	0	0.576	0.997	1.000
391	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(2), ANAPC4(2), ANAPC7(1), BTRC(1), CDC23(2), CDC27(7), CUL1(3), CUL2(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(1), SKP2(1), SMURF1(2), UBE2E3(1), WWP2(1)	17271283	28	26	24	5	4	2	5	6	11	0	0.330	0.998	1.000
392	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), ST6GAL1(1)	8471452	10	10	10	3	4	1	0	3	2	0	0.431	0.998	1.000
393	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NCKAP1(1), NTRK1(1), WASF3(1)	6505360	4	4	4	5	0	0	1	0	3	0	0.994	0.998	1.000
394	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PGM1(1), PYGL(1), PYGM(1), TREH(1)	5724309	7	7	7	3	3	2	1	1	0	0	0.588	0.998	1.000
395	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2B(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(2), NEK3(2), OCRL(2), PAK4(3), PIK3C2A(1), PIK3C2B(3), PIK3C2G(9), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(2)	48539354	137	107	130	26	36	27	22	29	23	0	0.000749	0.998	1.000
396	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	IMPDH1(2), POLD1(1), PRPS2(2)	5388002	5	5	5	2	4	0	0	1	0	0	0.681	0.998	1.000
397	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA5(1), PSMC3(1)	6795294	3	3	3	1	0	1	1	0	1	0	0.747	0.998	1.000
398	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(3), PSPH(5), SARDH(1), TARS(1)	18030751	47	41	45	10	15	10	2	15	5	0	0.0534	0.998	1.000
399	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR2(1), DNMT1(1), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(1)	4826843	6	6	6	9	3	0	0	1	2	0	0.996	0.998	1.000
400	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA5(1), PSMC3(1), UBE3A(1)	5504056	4	4	4	2	0	1	2	0	1	0	0.810	0.999	1.000
401	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1), UGT2B4(5)	7490332	15	15	15	9	5	4	0	3	3	0	0.870	0.999	1.000
402	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(3), CYP27A1(1), CYP7A1(1), SRD5A1(1), SRD5A2(1)	9935305	22	21	22	8	8	5	1	7	1	0	0.497	0.999	1.000
403	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(2), JAK1(2), JAK2(2), JAK3(2), STAT1(2), STAT3(1), STAT5B(1), TYK2(3)	7913677	15	15	15	5	6	1	0	5	3	0	0.560	0.999	1.000
404	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(2), CES1(2), ESCO1(1), MYST4(1), PLA1A(1), PPME1(1)	10827232	13	13	13	4	7	3	0	3	0	0	0.400	0.999	1.000
405	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), CHAT(2), DBH(1), DDC(3), GAD1(1), HDC(3), MAOA(1), PAH(2), SLC18A3(1), TPH1(2)	6170814	17	16	17	7	10	1	2	4	0	0	0.493	0.999	1.000
406	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), REN(5)	10909772	30	27	29	10	9	9	4	4	4	0	0.325	0.999	1.000
407	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(1), CREBBP(5), EP300(1), PRKAR1B(1), PRKAR2B(1), RXRA(3)	8820244	15	15	14	5	4	4	1	2	4	0	0.516	0.999	1.000
408	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(3), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), METTL6(1), PRMT8(1), SCLY(1)	10652488	15	14	14	4	5	4	0	4	2	0	0.361	0.999	1.000
409	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1)	10250027	6	6	6	1	2	1	1	1	1	0	0.458	0.999	1.000
410	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR2(4), HLA-DRA(1), ICAM1(1), ITGB2(5), PTPRC(2)	6496997	13	12	13	9	7	1	0	3	2	0	0.909	0.999	1.000
411	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), PSEN1(1), WNT1(1)	9251724	11	10	11	4	1	1	1	5	3	0	0.767	0.999	1.000
412	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	DIAPH2(3), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), PRIM1(1), RFC1(1), RFC4(1), RPA2(1), RPA4(2), UBA52(2), UBC(2)	21761691	33	33	33	6	7	7	4	11	4	0	0.0827	0.999	1.000
413	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(1), RPL10L(2), RPL11(2), RPL13A(1), RPL22L1(1), RPL36A(2), RPL3L(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1)	9754917	16	15	16	6	4	1	2	2	7	0	0.874	0.999	1.000
414	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1)	5221248	7	6	7	5	4	0	0	1	2	0	0.743	0.999	1.000
415	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(2), CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT2(1), MAOA(1), MAOB(2), NOS1(6), NOS3(3), OTC(3), P4HB(1), RARS(1)	19001662	49	44	48	12	26	7	5	11	0	0	0.0490	0.999	1.000
416	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(1), ESR1(1), MAPK1(2), MAPK3(1), SRC(2)	6283901	12	12	12	5	2	4	2	2	2	0	0.626	1.000	1.000
417	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), MTA1(1), MTA3(1), TUBA8(1)	4732712	4	4	4	5	2	0	0	1	1	0	0.949	1.000	1.000
418	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), ASAH1(1), CREB1(1), DAG1(2), EPHB2(3), FOS(1), MAPK1(2), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3)	12193480	19	19	19	5	5	3	6	2	3	0	0.344	1.000	1.000
419	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), AGXT(1), ASNS(2), CAD(3), CRAT(1), DARS(1), GAD1(1), GOT2(1), PC(2)	11111677	13	13	13	4	0	3	3	4	3	0	0.611	1.000	1.000
420	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(4), CRY1(1), CSNK1D(1), PER1(1), PER2(3), PER3(2)	7318793	12	12	11	5	4	4	0	1	3	0	0.744	1.000	1.000
421	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOX1(4), DBH(1), DCT(1), DDC(3), GOT2(1), MAOA(1), MAOB(2), TAT(2), TPO(4), TYR(1)	13547107	36	33	34	10	22	3	2	9	0	0	0.105	1.000	1.000
422	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2), MASP2(1), MBL2(1)	9180538	19	19	19	7	6	3	1	6	3	0	0.566	1.000	1.000
423	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), AKR1B10(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CEL(3), CYP27A1(1), CYP7A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1)	13592393	25	23	25	8	7	6	1	9	2	0	0.452	1.000	1.000
424	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1)	6425163	7	7	6	3	3	2	0	1	1	0	0.637	1.000	1.000
425	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(2), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), MLYCD(1)	12384096	22	21	22	7	10	5	0	6	1	0	0.277	1.000	1.000
426	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAPK8(1), NFKB1(1)	6230468	3	3	3	2	1	0	0	1	1	0	0.841	1.000	1.000
427	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PRKAR1B(1), PRKAR2B(1)	6841799	11	11	11	5	6	1	0	2	2	0	0.762	1.000	1.000
428	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	CP(4), EPRS(2), FECH(1), HCCS(1), HMBS(1), HMOX1(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1), UGT2B4(5)	11661543	24	23	24	8	7	4	2	8	3	0	0.453	1.000	1.000
429	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(1), POLL(1), POLQ(3)	7130758	6	6	6	3	2	0	0	3	1	0	0.918	1.000	1.000
430	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	AMT(2), MTHFD1(1), MTHFR(1)	7628474	4	4	4	2	1	0	2	0	1	0	0.802	1.000	1.000
431	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(4), HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2), SPAM1(4)	14827309	30	28	29	9	11	6	1	10	2	0	0.248	1.000	1.000
432	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), GNB1(1), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2)	8823440	11	11	10	6	2	1	0	5	3	0	0.910	1.000	1.000
433	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), CETP(2), CYP7A1(1), DGAT1(2), LCAT(1), LDLR(3), LRP1(9), SCARB1(1), SOAT1(3)	11679328	23	22	23	8	5	3	2	6	7	0	0.573	1.000	1.000
434	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), BTK(1), GSK3B(1), LYN(2), PFKL(1), PFKP(1), PLCG1(6), PRKCE(1), VAV2(2)	10739871	16	15	16	5	4	5	3	3	1	0	0.313	1.000	1.000
435	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(3), F2(2), F2RL3(2), MAPK1(2), MAPK7(1), MAPK8(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(4)	11753591	25	23	25	8	8	6	3	6	2	0	0.338	1.000	1.000
436	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ASS1(1), CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(3), GOT2(1), NOS1(6), NOS3(3), OTC(3), PARS2(1), PRODH(1), RARS(1)	15436392	39	37	38	10	21	4	6	8	0	0	0.121	1.000	1.000
437	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYD(2), DPYS(1), ENPP1(1)	7381229	4	4	4	2	0	0	0	4	0	0	0.875	1.000	1.000
438	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(6), MAP3K7(3), MAPK8(1), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(4), TLR3(1), TLR6(5), TLR7(4), TLR9(2)	15627801	43	41	41	12	14	11	4	9	5	0	0.155	1.000	1.000
439	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), ACYP1(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), ITGB1BP3(1), MYST4(1), YOD1(1)	11066044	9	9	9	3	3	5	0	0	1	0	0.433	1.000	1.000
440	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(6), CREB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3)	12653028	19	18	15	5	4	3	2	8	2	0	0.475	1.000	1.000
441	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(1), CALCR(8), CALCRL(1), CD97(1), CRHR2(2), ELTD1(5), EMR1(1), EMR2(1), GHRHR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(3), VIPR2(1)	11525318	31	28	31	10	14	1	5	9	2	0	0.338	1.000	1.000
442	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	AMT(2), MTHFD1(1), MTHFR(1)	8089772	4	4	4	2	1	0	2	0	1	0	0.803	1.000	1.000
443	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), BCL10(1), BTK(1), CARD11(5), CD19(1), CD22(6), CHUK(1), CR2(4), FOS(1), GSK3B(1), IFITM1(2), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(3), PPP3CB(1), PTPN6(1), VAV1(4), VAV2(2), VAV3(1)	31858151	141	108	129	31	32	28	16	30	35	0	0.00963	1.000	1.000
444	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IFNG(2), IKBKB(1), MAP3K1(6), MAP3K5(1), MAPK8(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3)	8306395	18	16	15	8	5	5	3	3	2	0	0.594	1.000	1.000
445	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLI(2), POLL(1), POLQ(3), PRIM1(1), PRIM2(1), REV1(2), REV3L(1)	17481158	17	17	17	4	5	2	1	7	2	0	0.488	1.000	1.000
446	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2)	7447271	7	7	7	6	2	1	0	2	2	0	0.980	1.000	1.000
447	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH3A1(2), CYP2C19(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), MYST4(1), YOD1(1)	13183837	11	10	11	3	5	4	0	1	1	0	0.292	1.000	1.000
448	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CREBBP(5), EP300(1), MAP2K1(1), MAP3K7(3), MAPK3(1), TGFBR1(2), TGFBR2(2)	10915497	16	16	16	6	2	5	4	1	4	0	0.567	1.000	1.000
449	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(2), BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(3), TNFRSF25(1), TNFSF10(2)	14326125	16	15	16	4	4	0	2	6	4	0	0.491	1.000	1.000
450	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(1), COX10(2), CP(4), EPRS(2), FECH(1), FTMT(4), HCCS(1), HMBS(1), HMOX1(1), MMAB(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2)	18007838	56	47	55	16	17	7	9	18	5	0	0.249	1.000	1.000
451	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ELOVL2(1), HADHA(1)	6187757	3	3	3	2	1	2	0	0	0	0	0.672	1.000	1.000
452	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), ESCO1(1), MYST4(1)	10655033	10	9	10	4	2	3	0	5	0	0	0.685	1.000	1.000
453	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(7), CALM1(1), CAMK2A(1), CGA(1), EGFR(92), ELK1(2), GNRHR(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K4(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2)	54804292	202	139	150	38	56	72	9	51	14	0	1.33e-07	1.000	1.000
454	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), BCL10(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CD4(1), CD8A(1), CHUK(1), CSF2(2), FOS(1), FYN(1), GRAP2(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PDCD1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PRKCQ(2), PTPN6(1), PTPRC(2), RASGRP1(1), SOS1(3), TEC(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3)	43417439	156	118	144	30	33	27	22	35	39	0	0.00270	1.000	1.000
455	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2)	14077921	23	22	23	7	9	6	2	4	2	0	0.351	1.000	1.000
456	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(5), EP300(1), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	9571067	13	12	13	5	3	3	1	3	3	0	0.592	1.000	1.000
457	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	CREB1(1), EP300(1), EPO(1), NOS3(3), P4HB(1)	7317846	7	7	7	5	4	1	0	1	1	0	0.910	1.000	1.000
458	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CSK(1), DAG1(2), DTYMK(1), EPHB2(3), FBXW7(1), GRAP2(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PLCG1(6), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP4(1), SOS1(3), VAV1(4), ZAP70(3)	23979960	49	45	49	10	13	8	7	12	9	0	0.0815	1.000	1.000
459	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(2), ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUD2(3), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2)	16844822	25	24	25	6	5	4	7	8	1	0	0.246	1.000	1.000
460	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1)	20698708	41	39	41	11	16	8	0	12	5	0	0.143	1.000	1.000
461	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), AXIN1(3), BTRC(1), CREBBP(5), CSNK1D(1), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(3), MYC(1), WIF1(1), WNT1(1)	12597628	20	19	20	9	2	4	3	5	6	0	0.835	1.000	1.000
462	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(1), APC2(3), AXIN1(3), AXIN2(1), BTRC(1), CAMK2A(1), CCND2(2), CCND3(1), CHD8(10), CREBBP(5), CSNK2B(2), CTBP2(3), CUL1(3), CXXC4(1), DAAM2(1), DKK1(1), DKK2(3), DVL1(1), DVL2(4), DVL3(1), EP300(1), FBXW11(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LRP6(2), MAP3K7(3), MAPK8(1), MMP7(2), MYC(1), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), ROCK1(2), ROCK2(1), RUVBL1(2), SMAD4(1), SOX17(1), TBL1X(1), TCF7L2(2), TP53(96), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	69295299	208	146	170	34	67	29	22	46	44	0	4.69e-07	1.000	1.000
463	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1)	7008492	9	9	9	8	3	2	0	3	1	0	0.963	1.000	1.000
464	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), ATP7A(3), COX10(2), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1)	16304612	22	22	22	6	6	5	2	8	1	0	0.285	1.000	1.000
465	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CHUK(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(6), MAP4K2(1), MAPK8(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1)	10369805	18	16	16	9	5	5	1	4	3	0	0.765	1.000	1.000
466	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), MAPK8(1), RAF1(1), SOS1(3), STAT5B(1)	10065189	15	15	15	7	4	1	2	5	3	0	0.892	1.000	1.000
467	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC23A2(1), SLC2A1(2), SLC2A3(2)	10865479	26	23	26	10	7	7	4	4	4	0	0.421	1.000	1.000
468	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1B(1), TRAF1(1)	9591812	15	14	13	6	4	5	1	4	1	0	0.529	1.000	1.000
469	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2), TAT(2)	8858774	11	11	10	6	5	2	0	2	2	0	0.848	1.000	1.000
470	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), NOS1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(1)	10936813	31	29	31	11	22	1	2	5	1	0	0.289	1.000	1.000
471	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	DLD(2), IDH3A(1), OGDH(3), PC(2), PDHA1(1), PDHA2(3), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2)	12120642	17	16	15	7	3	6	0	4	4	0	0.735	1.000	1.000
472	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM1(1), CAPNS1(1), EP300(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1), SYT1(1)	10378405	17	17	17	7	5	3	3	3	3	0	0.578	1.000	1.000
473	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(1), C1QC(1), C1S(3), C2(2), C3(6), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(2), C8B(4), C9(2), CD46(2), CD55(1), CD59(1), CFB(1), CFH(2), CFI(1), CR2(4), F10(1), F13A1(3), F13B(1), F2(2), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), KNG1(2), MASP2(1), MBL2(1), PLAT(3), PLG(2), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(1), SERPINE1(2), SERPING1(1), VWF(7)	38739089	105	84	105	28	32	22	11	25	15	0	0.0246	1.000	1.000
474	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(1), EXTL1(1), HS3ST1(2), HS3ST3A1(2), NDST3(1), NDST4(6)	8875178	13	12	13	5	5	1	5	2	0	0	0.559	1.000	1.000
475	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), BIRC3(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	11644938	17	16	17	6	2	4	4	5	2	0	0.574	1.000	1.000
476	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADS(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), HADHA(1), MCCC1(1), MUT(1), PCCA(2), PCCB(1)	15330683	25	24	24	9	13	5	4	2	1	0	0.314	1.000	1.000
477	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AGPAT6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK2(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1)	25180627	42	41	42	10	16	7	0	13	6	0	0.0985	1.000	1.000
478	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2), XYLB(1)	11609436	40	37	39	14	11	5	7	12	5	0	0.514	1.000	1.000
479	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOX1(4), CARM1(3), DBH(1), DCT(1), DDC(3), ESCO1(1), GOT2(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), MYST4(1), PRMT8(1), TAT(2), TPO(4), TYR(1), TYRP1(2)	25411529	47	43	43	11	25	7	2	10	3	0	0.0463	1.000	1.000
480	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2(2), BCL2A1(1), BOK(1), CASP1(2), CASP10(1), CASP9(1), CRADD(1), DAXX(3), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), SFRS2IP(4), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	18750513	25	23	24	9	5	4	1	7	8	0	0.726	1.000	1.000
481	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CYB5R1(1), GFPT1(1), GNPDA1(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), NPL(1), RENBP(2)	12227223	14	14	14	5	7	0	3	2	2	0	0.589	1.000	1.000
482	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(2), ADH1B(2), ADH1C(2), AKR1C1(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), CYP1A2(2), CYP1B1(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), EPHX1(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2)	24449405	79	68	78	23	29	10	9	25	6	0	0.125	1.000	1.000
483	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(3), ADCY9(4), AK1(1), ARL4D(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), ERO1L(1), PLCG1(6), PLCG2(3), PRKCA(1), TRIM23(1)	15784313	34	32	34	10	11	7	4	8	4	0	0.265	1.000	1.000
484	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPT(2), ALPI(1), ALPP(3), ALPPL2(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), PON1(2)	12480009	45	42	44	15	25	3	7	7	3	0	0.258	1.000	1.000
485	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(2), ARSE(3), CARM1(3), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(2), HSD17B3(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(2), SULT2B1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2)	21489699	62	51	60	20	20	12	8	16	6	0	0.219	1.000	1.000
486	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(4), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), NCKAP1(1), PER1(1), PER2(3), PIGF(1), SF3A3(1), ZFR(2)	15642781	18	17	17	6	7	2	2	2	5	0	0.615	1.000	1.000
487	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(2), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(1), VARS2(2), WARS(1), YARS2(1)	23158886	27	27	27	6	4	4	5	10	4	0	0.368	1.000	1.000
488	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM1(1), ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK3(1), MAPK8(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4)	16318085	37	33	35	12	8	9	7	8	5	0	0.273	1.000	1.000
489	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PITX2(3), PLD1(1)	19248447	31	27	31	9	8	11	3	5	4	0	0.146	1.000	1.000
490	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(8), CDR1(1), DGKI(2), FAU(2), RPL10(2), RPL11(2), RPL13A(1), RPL15(1), RPL22(1), RPL3L(1), RPL5(7), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(2), UBC(2)	22506754	48	43	48	10	11	8	7	9	13	0	0.169	1.000	1.000
491	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ACY3(1), AGXT(1), ASNS(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DLD(2), GAD1(1), GOT2(1), PC(2), PDHA1(1), PDHA2(3)	16160281	22	22	22	9	4	6	3	4	5	0	0.718	1.000	1.000
492	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CSDA(1), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L2(2), EPB41L3(5), F11R(1), HCLS1(3), INADL(2), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MAGI3(1), MLLT4(4), MPDZ(1), MYH1(6), MYH10(1), MYH11(5), MYH13(8), MYH14(3), MYH15(3), MYH2(9), MYH3(2), MYH4(5), MYH6(2), MYH7(4), MYH7B(3), MYH8(7), MYH9(3), NRAS(1), OCLN(1), PARD3(1), PARD6B(2), PPM1J(2), PPP2R1B(1), PPP2R3A(2), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PTEN(90), SPTAN1(3), SRC(2), SYMPK(3), TJAP1(2), TJP1(3), TJP3(5), ZAK(3)	83062647	245	168	226	41	75	43	24	41	62	0	9.79e-07	1.000	1.000
493	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CAMK1(1), ELK1(2), GNA15(1), GNB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NCF1(1), NCF2(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PIK3C2G(9), PLCB1(1), PPP3CB(1), RAF1(1), SYT1(1)	16433122	42	40	40	14	14	8	7	5	8	0	0.283	1.000	1.000
494	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), PFKFB1(2), PFKFB4(1), PFKP(1), PMM1(1)	10237385	13	12	13	9	8	1	1	2	1	0	0.876	1.000	1.000
495	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(1), ATP8A1(2), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CX3CR1(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(1), LHCGR(2), MC2R(3), MC3R(4), MC4R(3), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), PPYR1(1), SSTR2(1), SSTR3(1), SSTR4(4), TACR3(4), TSHR(1)	22288669	67	65	67	23	42	9	3	11	2	0	0.0678	1.000	1.000
496	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), GTF2H1(2), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2)	14905429	15	14	15	7	2	4	2	4	3	0	0.799	1.000	1.000
497	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(1), AXIN1(3), CCND2(2), CCND3(1), DVL1(1), DVL2(4), DVL3(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LDLR(3), MYC(1), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1)	25660388	46	41	44	12	13	6	6	12	9	0	0.195	1.000	1.000
498	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(3), CREBBP(5), EP300(1), ESR1(1), GRIP1(7), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(2), NRIP1(2), POLR2A(2), TBP(2)	19873872	34	32	33	10	9	12	2	5	6	0	0.218	1.000	1.000
499	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(1), DRD2(1), EGF(3), EGFR(92), GJD2(3), GRM1(4), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK7(1), NPR1(1), NRAS(1), PDGFD(2), PDGFRA(13), PDGFRB(3), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(3), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3)	56573876	221	149	170	47	60	72	13	55	21	0	2.68e-06	1.000	1.000
500	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(2), AOX1(4), ASMT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), KYNU(1), MAOA(1), MAOB(2), TPH1(2), WARS(1)	23483138	65	54	63	19	36	6	7	13	3	0	0.0873	1.000	1.000
501	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACTN1(2), ACTN3(1), ACVR1C(2), CREBBP(5), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), EGFR(92), EP300(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(3), INSR(2), LMO7(2), MAP3K7(3), MAPK1(2), MAPK3(1), MET(3), MLLT4(4), PARD3(1), PTPN6(1), PTPRB(3), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(3), SMAD4(1), SNAI2(2), SORBS1(2), SRC(2), TCF7L2(2), TGFBR1(2), TGFBR2(2), TJP1(3), WAS(1), WASF3(1)	51083237	172	123	124	38	30	59	13	51	19	0	0.000705	1.000	1.000
502	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(1), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RYR1(4)	19728696	37	35	37	11	16	11	4	3	3	0	0.0809	1.000	1.000
503	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), ESR1(1), ESR2(3), HNF4A(4), NPM1(1), NR1H2(2), NR1H3(1), NR1I2(1), NR1I3(2), NR2C2(1), NR2F2(2), NR4A1(2), NR5A2(1), PGR(5), PPARA(1), PPARG(1), RARB(1), RORC(3), RXRA(3), THRA(1)	18016236	37	36	37	12	13	5	3	11	5	0	0.478	1.000	1.000
504	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AKAP1(1), AKAP11(1), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), CALM1(1), GNA15(1), GNAO1(1), GNB1(1), GNG5(1), GNGT2(1), ITPR1(5), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1C(4), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKD3(2)	50071542	80	65	78	15	28	19	8	15	10	0	0.00233	1.000	1.000
505	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2B1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(2), PABPC3(4)	18782691	17	17	17	9	5	3	1	5	3	0	0.893	1.000	1.000
506	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADS(4), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(4), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1)	20881703	30	28	30	10	13	4	2	7	4	0	0.342	1.000	1.000
507	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2H1(2), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(9), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(4), TBPL2(1)	15385102	30	27	30	10	8	3	3	12	4	0	0.694	1.000	1.000
508	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(2), AKT1(1), ANGPTL2(1), CFL2(1), FLNA(5), FLNC(3), FSCN2(1), GDI1(1), MYH2(9), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), ROCK1(2), ROCK2(1), RPS4X(1), VASP(1)	20574656	37	34	36	13	21	3	3	4	6	0	0.290	1.000	1.000
509	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2U1(1), CYP4A11(4), CYP4F2(3), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), GPX5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	16641928	40	35	39	14	21	5	1	10	3	0	0.298	1.000	1.000
510	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ABP1(4), ACMSD(1), ALDH1A3(1), ALDH3A1(2), AOC2(2), AOX1(4), ASMT(1), CARM1(3), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), NFX1(1), OGDH(3), OGDHL(3), PRMT8(1), TPH1(2), WARS(1)	25872242	47	44	43	14	21	6	1	12	7	0	0.267	1.000	1.000
511	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ACYP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	15769587	27	26	27	10	13	5	0	7	2	0	0.483	1.000	1.000
512	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(1), ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), MGAT5B(1), ST6GAL1(1)	18156388	13	13	13	9	5	3	0	3	2	0	0.896	1.000	1.000
513	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(2), AGPAT2(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(1), GNPAT(1), GPD2(1), LCAT(1), MYST4(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1), PTDSS1(3)	28140861	42	41	42	12	16	8	2	13	3	0	0.188	1.000	1.000
514	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CALM1(1), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(5), DCT(1), DVL1(1), DVL2(4), DVL3(1), EP300(1), FZD1(1), FZD10(3), FZD9(1), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(2), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT11(1), WNT2(5), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	46633048	95	83	92	25	36	19	11	17	12	0	0.0287	1.000	1.000
515	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(2), BCL2(2), DLG4(3), LPA(4), MAP3K1(6), MAP3K5(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PLD1(1), ROCK1(2), ROCK2(1), SRF(1)	20971240	36	31	34	11	7	13	3	7	6	0	0.353	1.000	1.000
516	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(2), AGPAT2(1), CHAT(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(3)	21468554	44	39	44	15	16	8	2	13	5	0	0.328	1.000	1.000
517	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(6), CHUK(1), CREB1(1), DAXX(3), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), SP1(1), STAT1(2), TGFBR1(2)	41051104	74	66	68	19	19	19	8	18	10	0	0.0832	1.000	1.000
518	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BRAF(6), CD244(1), CSF2(2), FYN(1), GZMB(2), ICAM1(1), ICAM2(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(2), NFATC2(2), NFATC4(2), NRAS(1), PAK1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PTPN6(1), RAF1(1), SH2D1A(1), SH2D1B(2), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3)	48611244	185	130	169	46	37	29	28	50	41	0	0.0235	1.000	1.000
519	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(7), ACOT12(1), ACYP1(1), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), LDHAL6A(1), LDHAL6B(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	19942006	34	34	34	12	15	5	1	11	2	0	0.455	1.000	1.000
520	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1)	22409189	43	39	43	16	21	7	7	5	3	0	0.362	1.000	1.000
521	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1)	22409189	43	39	43	16	21	7	7	5	3	0	0.362	1.000	1.000
522	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(2), ACVRL1(1), AMHR2(1), BMP2(1), BMP4(1), BMP5(4), BMP6(1), BMPR2(1), CDKN2B(2), CHRD(2), CREBBP(5), CUL1(3), DCN(1), E2F4(1), EP300(1), GDF5(1), GDF6(1), GDF7(1), ID1(1), IFNG(2), INHBA(1), INHBE(1), LEFTY2(2), MAPK1(2), MAPK3(1), MYC(1), PITX2(3), PPP2R1B(1), RBL1(2), ROCK1(2), ROCK2(1), SMAD4(1), SMAD7(1), SMURF1(2), SP1(1), TFDP1(1), TGFBR1(2), TGFBR2(2), THBS1(2), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1)	42351901	67	61	67	17	16	13	9	17	12	0	0.112	1.000	1.000
523	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), APOA5(1), AQP7(2), CD36(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(4), CYP7A1(1), CYP8B1(2), EHHADH(1), FABP1(1), FABP6(1), GK2(1), ME1(1), MMP1(2), NR1H3(1), OLR1(1), PCK1(3), PLTP(1), PPARA(1), PPARG(1), RXRA(3), SLC27A1(1), SLC27A2(6), SLC27A6(4), SORBS1(2), UBC(2)	27946314	54	48	54	17	24	7	5	14	4	0	0.201	1.000	1.000
524	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(2), CREBBP(5), CTBP2(3), DLL1(1), DTX1(1), DTX2(1), DTX3L(1), DTX4(2), DVL1(1), DVL2(4), DVL3(1), EP300(1), HDAC2(3), HES1(1), JAG1(3), JAG2(4), LFNG(1), MAML1(2), MAML3(1), MFNG(1), NCOR2(2), NCSTN(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PSEN1(1), RBPJL(3)	29980314	54	49	53	18	12	10	9	12	11	0	0.424	1.000	1.000
525	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(2), CABIN1(5), CALM1(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CEBPB(1), CREBBP(5), CSF2(2), CSNK2B(2), EGR2(2), EGR3(1), EP300(1), FCER1A(2), FOS(1), GATA4(2), GRLF1(2), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MAPK8(1), MEF2A(2), MEF2D(1), MYF5(2), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(1), PAK1(1), PPP3CB(1), PTPRC(2), RPL13A(1), SFN(1), SP1(1), SP3(1), TRPV6(7), VAV1(4), VAV2(2), VAV3(1)	38902187	80	69	80	25	21	13	11	19	16	0	0.186	1.000	1.000
526	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC2(1), BIRC3(1), BRAF(6), CAV3(1), CCND2(2), CCND3(1), COL11A1(2), COL11A2(7), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), CRKL(1), DOCK1(2), EGF(3), EGFR(92), ELK1(2), ERBB2(1), FIGF(2), FLNA(5), FLNB(2), FLNC(3), FLT1(5), FN1(3), FYN(1), GRLF1(2), GSK3B(1), HGF(1), IGF1(2), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KDR(8), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), MET(3), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PARVG(1), PDGFD(2), PDGFRA(13), PDGFRB(3), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PRKCA(1), PRKCG(2), PTEN(90), PXN(1), RAF1(1), RELN(13), ROCK1(2), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS1(2), THBS3(1), THBS4(2), TLN2(2), TNC(2), TNN(1), TNXB(3), VASP(1), VAV1(4), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VEGFC(1), VWF(7), ZYX(2)	159347082	584	235	500	134	124	144	59	140	117	0	5.86e-08	1.000	1.000
527	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1C(2), AKT1(1), BRAF(6), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1F(1), CACNA1G(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB3(2), CACNG2(1), CACNG3(2), CHUK(1), CRKL(1), DAXX(3), DDIT3(1), DUSP10(1), DUSP5(1), DUSP8(1), EGF(3), EGFR(92), ELK1(2), ELK4(1), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(2), FLNA(5), FLNB(2), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MYC(1), NF1(30), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(1), PAK1(1), PDGFRA(13), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PPM1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RAPGEF2(1), RASGRF1(3), RASGRF2(2), RASGRP1(1), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), STK3(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(2), TGFBR2(2), TNFRSF1A(1), TP53(96), ZAK(3)	123217220	453	220	357	91	117	108	39	108	76	5	6.12e-10	1.000	1.000
528	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(3), ARHGEF12(1), ARHGEF6(2), ARHGEF7(2), ARPC2(1), BDKRB1(1), BRAF(6), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGF(3), EGFR(92), EZR(4), F2(2), FGD3(2), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(4), FGFR4(2), FN1(3), GRLF1(2), GSN(1), INS(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(5), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(2), LIMK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(1), MYH14(3), MYH9(3), MYLK(2), NCKAP1(1), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PDGFRA(13), PDGFRB(3), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PPP1CC(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(5), TMSL3(1), VAV1(4), VAV2(2), VAV3(1), WAS(1)	118774508	376	208	308	87	89	86	36	106	59	0	5.61e-05	1.000	1.000
529	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(4), AGTR1(1), ATP2A1(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), AVPR1A(2), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1F(1), CACNA1G(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CALM1(1), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), CYSLTR2(1), DRD1(1), EGFR(92), ERBB2(1), ERBB4(1), GNA15(1), GRIN2A(10), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(2), GRPR(1), HRH2(3), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), ITPR1(5), ITPR2(3), ITPR3(5), LHCGR(2), MYLK(2), NOS1(6), NOS3(3), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRA(13), PDGFRB(3), PHKA1(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PPID(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(3), RYR1(4), RYR2(30), RYR3(18), TACR3(4), TNNC2(1), TRPC1(1), VDAC1(1), VDAC2(1)	115956223	358	198	308	96	142	79	24	82	31	0	6.87e-06	1.000	1.000
530	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(1), ADRA2B(1), ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), C5AR1(3), CALCR(8), CALCRL(1), CCKAR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), CYSLTR2(1), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2(2), F2RL3(2), FSHR(1), GABBR2(1), GABRA1(6), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRA6(11), GABRB1(1), GABRB2(6), GABRB3(6), GABRD(1), GABRE(2), GABRG1(2), GABRG2(4), GABRP(1), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GHRHR(1), GHSR(2), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(1), GLRA3(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(2), GRIK1(2), GRIK2(1), GRIK3(4), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRIN3A(2), GRIN3B(1), GRM1(4), GRM3(9), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LEPR(1), LHCGR(2), MC2R(3), MC3R(4), MC4R(3), MC5R(2), MCHR1(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX2(1), P2RX5(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY8(3), PARD3(1), PPYR1(1), PRLHR(1), PRSS1(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(1), SSTR4(4), SSTR5(1), TAAR1(1), TACR3(4), THRA(1), TRPV1(2), TSHR(1), UTS2R(1), VIPR2(1)	94602142	291	173	289	118	163	36	23	54	15	0	0.0946	1.000	1.000
531	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	COL11A1(2), COL11A2(7), COL17A1(3), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DES(3), DSC1(3), DSC2(3), DSC3(4), DSG1(2), DSG3(9), DSG4(5), FN1(3), GJA10(1), GJA9(1), GJB3(2), GJB4(1), GJC1(1), GJC3(1), GJD2(3), INA(1), ITGB4(3), KRT1(1), KRT12(2), KRT13(3), KRT14(1), KRT15(2), KRT16(2), KRT17(1), KRT18(2), KRT2(1), KRT20(2), KRT23(1), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33A(2), KRT33B(1), KRT34(2), KRT35(1), KRT36(1), KRT37(4), KRT38(1), KRT39(2), KRT4(1), KRT40(2), KRT6B(1), KRT74(1), KRT75(2), KRT76(1), KRT79(3), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(3), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), LMNB2(1), NES(1), RELN(13), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(1), TNXB(3), VIM(1), VWF(7)	106798599	263	169	262	115	110	52	23	50	28	0	0.589	1.000	1.000
532	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	251	AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL19(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CD70(1), CSF1R(1), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL6(1), EDA(1), EDAR(1), EGF(3), EGFR(92), EPO(1), FLT1(5), FLT3(4), FLT4(2), GDF5(1), GH1(1), HGF(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL15RA(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(6), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), INHBA(1), INHBE(1), KDR(8), KIT(3), KITLG(1), LEPR(1), MET(3), MPL(3), OSM(1), OSMR(2), PDGFRA(13), PDGFRB(3), PPBP(1), RELT(1), TGFBR1(2), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(2), TNFSF18(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFB(1), VEGFC(1), XCL1(2), XCR1(1)	75966883	282	168	230	88	81	73	16	86	26	0	0.0118	1.000	1.000
533	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(2), CD36(1), CD44(3), COL11A1(2), COL11A2(7), COL1A1(1), COL1A2(11), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DAG1(2), FN1(3), FNDC1(3), FNDC4(1), HSPG2(8), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), RELN(13), SDC1(1), SDC2(1), SDC4(1), SV2B(2), SV2C(2), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(1), TNXB(3), VWF(7)	96601624	213	146	213	84	76	49	22	38	28	0	0.271	1.000	1.000
534	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), CBL(1), CBLB(1), CCND2(2), CCND3(1), CREBBP(5), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), EP300(1), EPO(1), GH1(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), IRF9(1), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MPL(3), MYC(1), OSM(1), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), PTPN6(1), SOCS1(1), SOCS4(1), SOS1(3), SPRY3(2), STAM2(1), STAT1(2), STAT2(1), STAT3(1), STAT4(2), STAT5B(1), STAT6(1), TPO(4), TYK2(3)	62064230	198	141	186	48	52	33	23	48	42	0	0.0166	1.000	1.000
535	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(5), ACACB(7), AKT1(1), BRAF(6), CALM1(1), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(2), FBP2(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INS(1), INSR(2), IRS1(4), IRS4(3), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK8(1), NRAS(1), PCK1(3), PDE3A(3), PDE3B(3), PFKL(1), PFKP(1), PHKA1(2), PHKG1(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(1), PPP1CC(1), PPP1R3A(7), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(5), PYGB(2), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS1(1), SOCS4(1), SORBS1(2), SOS1(3), SREBF1(1), TRIP10(1), TSC2(4)	68833627	194	139	178	42	48	32	21	56	37	0	0.00397	1.000	1.000
536	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CTNNA1(2), CTNNA2(2), CTNNA3(2), CYBB(1), EZR(4), F11R(1), GRLF1(2), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(5), MAPK13(1), MLLT4(4), MMP9(2), MSN(1), NCF1(1), NCF2(2), NOX3(5), OCLN(1), PIK3CA(33), PIK3CB(4), PIK3CG(7), PIK3R1(33), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), RASSF5(1), ROCK1(2), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(4), VAV2(2), VAV3(1), VCAM1(1)	53275755	185	137	173	51	54	24	22	44	41	0	0.0832	1.000	1.000
537	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP1A4(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1S(7), CACNB3(2), CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GJB4(1), GNAO1(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(18), SFN(1), YWHAH(1)	80885001	187	134	185	59	84	31	18	36	18	0	0.0219	1.000	1.000
538	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(2), ABLIM3(4), ARHGEF12(1), CFL2(1), DCC(6), DPYSL5(2), EFNA3(1), EFNA5(2), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(3), EPHA4(1), EPHA5(4), EPHA6(4), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(3), EPHB4(2), EPHB6(4), FES(1), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(5), LIMK2(2), LRRC4C(2), MAPK1(2), MAPK3(1), MET(3), NFATC2(2), NFATC4(2), NGEF(1), NRAS(1), NRP1(1), NTN1(2), NTN4(4), NTNG1(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PLXNA1(1), PLXNA2(3), PLXNA3(1), PLXNB1(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA3C(11), SEMA3E(8), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(3), SLIT3(9), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5C(3), UNC5D(1)	84741214	164	125	161	56	46	28	21	48	21	0	0.273	1.000	1.000
539	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP2A3(2), CACNB3(2), CALCA(1), CALM1(1), CAMK2A(1), CNN2(1), CORIN(2), DGKZ(1), FOS(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), GUCY1A3(1), IL1B(1), IL6(1), ITPR1(5), ITPR2(3), ITPR3(5), MIB1(4), NFKB1(1), NOS1(6), NOS3(3), PDE4B(1), PLCD1(3), PLCG1(6), PLCG2(3), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(2), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(18), SFN(1), SP1(1), TNXB(3), YWHAH(1)	74591901	165	123	164	50	74	24	14	34	19	0	0.0164	1.000	1.000
540	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	CADM1(1), CADM3(1), CD2(1), CD22(6), CD276(1), CD28(1), CD4(1), CD58(1), CD6(2), CD86(2), CD8A(1), CDH15(2), CDH4(2), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(2), CNTNAP2(13), F11R(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(2), ITGAM(5), ITGAV(1), ITGB1(1), ITGB2(5), ITGB7(3), ITGB8(1), L1CAM(5), MAG(3), MPZL1(2), NCAM1(2), NEGR1(2), NEO1(1), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(2), NRXN1(5), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PTPRC(2), PTPRF(5), PTPRM(3), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(2), SELP(2), SELPLG(2), SIGLEC1(2), VCAM1(1), VCAN(3)	63278650	145	111	145	65	72	15	14	31	13	0	0.619	1.000	1.000
541	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CHML(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2RL3(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37(2), GPR4(2), GPR50(1), GPR6(1), GPR77(1), GPR83(2), GPR85(2), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LHCGR(2), MC3R(4), MC4R(3), MC5R(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR1C1(1), OR1F1(1), OR2H1(3), OR7A5(1), OR7C1(1), P2RY10(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR2(1), SSTR3(1), SSTR4(4), SUCNR1(1)	51824578	139	108	138	61	91	17	7	19	5	0	0.163	1.000	1.000
542	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN3(1), DES(3), DMD(11), FAM48A(2), MYBPC3(1), MYH3(2), MYH6(2), MYH7(4), MYH8(7), MYL3(1), MYOM1(2), NEB(7), TMOD1(1), TNNC2(1), TNNT1(3), TNNT2(1), TPM3(1), TTN(95), VIM(1)	58786986	147	104	145	36	60	17	12	43	15	0	0.0305	1.000	1.000
543	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AK1(1), AK5(1), AK7(5), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NME7(2), NPR1(1), NT5C1B(2), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(3), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PFAS(1), PKLR(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), PRPS1L1(2), PRPS2(2), RRM2(1), XDH(3)	70002713	108	87	107	32	43	23	11	20	11	0	0.0578	1.000	1.000
544	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD19(1), CD1B(1), CD1D(4), CD1E(2), CD2(1), CD22(6), CD33(5), CD36(1), CD37(1), CD38(1), CD3E(2), CD3G(1), CD4(1), CD44(3), CD5(2), CD55(1), CD59(1), CD7(2), CD8A(1), CR2(4), CSF1R(1), CSF2(2), CSF2RA(1), CSF3R(1), DNTT(2), EPO(1), FCER2(1), FLT3(4), GYPA(1), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(5), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(4)	34932085	103	84	102	36	49	12	7	19	16	0	0.208	1.000	1.000
545	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(1), AMY2B(3), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), ENPP1(1), EP400(6), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), MOV10L1(4), PGM1(1), PYGB(2), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(3), SMARCA2(3), SMARCA5(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2A3(6), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B28(6), UGT2B4(5), UGT2B7(2), UXS1(2)	52960612	98	82	97	33	35	13	12	27	11	0	0.387	1.000	1.000
546	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(1), ABCA10(4), ABCA12(1), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(3), ABCA7(2), ABCA9(3), ABCB1(10), ABCB11(2), ABCB4(6), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(1), ABCC10(2), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(1), ABCC9(14), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), ABCG5(1), ABCG8(1), CFTR(2), TAP1(1), TAP2(4)	50854698	101	81	100	33	37	14	12	28	10	0	0.182	1.000	1.000
547	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), CAPN1(2), CAPN11(2), CAPN6(2), CAPNS1(1), CAV3(1), CSK(1), DOCK1(2), FYN(1), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(5), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK3(1), PAK4(3), PIK3R2(3), PXN(1), ROCK1(2), ROCK2(1), SDCCAG8(2), SORBS1(2), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2)	57536716	96	81	96	35	37	15	9	24	11	0	0.340	1.000	1.000
548	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(6), CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(2), GRM1(4), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IGF1(2), IGF1R(3), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), LYN(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOS1(6), NOS3(3), NPR1(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), RAF1(1), RYR1(4)	47362190	89	77	84	39	37	17	5	20	10	0	0.662	1.000	1.000
549	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(3), ADCY8(2), BRAF(6), CACNA1C(5), CALM1(1), CAMK2A(1), CAMK4(1), CREBBP(5), EP300(1), GRIA1(2), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(2), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP1CC(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2)	42840423	88	72	83	30	40	15	7	19	7	0	0.201	1.000	1.000
550	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(7), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), ATP5I(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(2), PDE4B(1), PDE6B(2), PDE8A(1), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3), PRPS1L1(2), PRPS2(2), RRM2(1)	54960862	80	68	80	26	33	14	5	17	11	0	0.251	1.000	1.000
551	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	CARM1(3), DOT1L(1), EHMT2(2), EZH2(3), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(3), MEN1(3), MLL(3), MLL2(6), MLL3(10), MLL4(5), MLL5(1), NSD1(1), OGT(1), PPP1CC(1), PRDM7(1), PRDM9(10), PRMT8(1), RBBP5(2), SETD1A(3), SETD2(3), SETDB1(1), SMYD3(2), SUV39H2(1), SUV420H1(1), SUZ12(1), WHSC1(1)	51184349	73	62	72	23	15	15	7	27	9	0	0.479	1.000	1.000
552	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(7), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), AKT1(1), CAMKK1(1), CD36(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(4), IRS4(3), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(3), PPARA(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(4), RXRA(3), SLC2A1(2), STAT3(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(3)	35507524	63	60	63	22	22	10	3	18	10	0	0.379	1.000	1.000
553	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), CHSY1(2), EXT2(1), EXTL1(1), FUT8(1), GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), HS3ST1(2), HS3ST3A1(2), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(6), OGT(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(7), XYLT1(1), XYLT2(2)	47111016	68	59	68	26	30	10	8	12	8	0	0.393	1.000	1.000
554	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(1), ADCY6(2), ADCY8(2), CACNA1A(1), CACNA1B(6), GNAT3(4), GNB1(1), GRM4(2), ITPR3(5), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(3), SCNN1G(4), TAS1R1(3), TAS1R2(2), TAS2R1(2), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R4(1), TAS2R41(4), TAS2R5(1), TAS2R60(1), TRPM5(1)	24598085	61	54	59	27	30	7	6	9	9	0	0.661	1.000	1.000
555	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), COL2A1(2), CPSF1(4), CSTF1(1), CSTF2(1), DDIT3(1), DDX20(1), DHX38(1), DHX8(1), DICER1(5), FUS(1), LOC440563(2), NCBP2(1), NONO(2), NUDT21(1), NXF1(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SF3B4(1), SFRS16(1), SFRS2(1), SFRS5(2), SFRS8(2), SNRPB(1), SRPK1(2), SRPK2(1), SRRM1(1)	45223716	58	54	58	13	17	7	8	11	15	0	0.187	1.000	1.000
556	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	CCR3(1), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(5), CHRM2(3), CHRM3(1), EMR2(1), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(6), GPR132(2), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GPR77(1), GRM1(4), GRPR(1), LGR6(1), LPHN2(1), LPHN3(3), NTSR1(3), OR2M4(2), OR8G2(1), PTGFR(1), SMO(1), SSTR2(1), TSHR(1)	28557677	58	51	58	37	31	4	6	14	3	0	0.975	1.000	1.000
557	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NME7(2), NT5C1B(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(2), UCK1(1), UPP1(2), UPP2(1)	34741221	48	40	47	15	10	12	9	13	4	0	0.291	1.000	1.000
558	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(2), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PFKL(1), PFKP(1), PGAM4(1), PGK1(1), PGK2(1), PGM1(1), PKLR(1)	24821032	42	39	42	17	18	6	2	13	3	0	0.522	1.000	1.000
559	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(3), ALPPL2(4), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), EP400(6), MOV10L1(4), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1)	26849354	40	38	40	13	14	8	4	10	4	0	0.383	1.000	1.000
560	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CD4(1), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HSP90AB1(2), IFNA10(2), IFNA21(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), NFYB(1), PDIA3(1), RFX5(1), TAP1(1), TAP2(4)	19866832	42	37	42	21	17	7	5	8	5	0	0.842	1.000	1.000
561	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PFKP(1), PGK1(1), PGM1(1), PKLR(1)	20800813	39	36	39	16	19	7	1	10	2	0	0.504	1.000	1.000
562	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PFKP(1), PGK1(1), PGM1(1), PKLR(1)	20800813	39	36	39	16	19	7	1	10	2	0	0.504	1.000	1.000
563	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(1), AMY2B(3), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), PGM1(1), PYGB(2), PYGL(1), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1), UGT2B4(5), UXS1(2)	24417353	41	36	41	20	20	5	2	8	6	0	0.833	1.000	1.000
564	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), GOT2(1), HK2(2), HK3(2), LDHAL6B(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PFKL(1), PFKP(1), PGK1(1), PGK2(1), PKLR(1), TNFAIP1(1)	18088342	32	32	32	16	14	5	1	10	2	0	0.747	1.000	1.000
565	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALNT1(2), B3GALT5(1), B3GNT3(2), B4GALNT1(1), B4GALT2(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GBGT1(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL6(2), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1)	20782116	31	31	31	12	10	3	3	11	4	0	0.703	1.000	1.000
566	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NT5E(2), NUDT2(1), POLD1(1), POLE(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3), RRM2(1), TXNRD1(1), UCK1(1), UPP1(2)	24550531	33	30	33	13	4	6	6	12	5	0	0.775	1.000	1.000
567	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP4A(2), ATP5A1(1), ATP5B(1), ATP5I(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), COX10(2), COX7C(1), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA13(1), NDUFA4(1), NDUFA9(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1)	23891498	31	29	31	11	11	6	4	8	2	0	0.459	1.000	1.000
568	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASS(3), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1), HSD17B4(1), NSD1(1), OGDH(3), OGDHL(3), PIPOX(1), SETD1A(3), SETDB1(1), SUV39H2(1)	24875144	27	27	24	14	9	5	0	6	7	0	0.942	1.000	1.000
569	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(1), WBSCR17(7)	13745214	29	27	29	10	13	4	1	6	5	0	0.530	1.000	1.000
570	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(2), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(2), HSD17B3(1), SRD5A1(1), SRD5A2(1), STS(2), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1), UGT2B4(5)	11678778	28	26	28	13	10	8	1	6	3	0	0.600	1.000	1.000
571	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GRM1(4), GRM3(9), GRM4(2), GRM5(2), GRM7(2), GRM8(5)	8922419	28	26	27	22	20	0	1	6	1	0	0.978	1.000	1.000
572	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ACADS(4), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(3), PLA1A(1), PPME1(1)	17357596	25	25	25	10	10	5	2	4	4	0	0.547	1.000	1.000
573	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(1), B4GALT2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PFKL(1), PFKP(1), PGM1(1)	16585140	25	24	25	10	13	4	2	4	2	0	0.500	1.000	1.000
574	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(5), SELP(2), SELPLG(2), VCAM1(1)	10603340	25	24	25	14	7	3	3	7	5	0	0.872	1.000	1.000
575	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PFKP(1), PGM1(1)	13964693	24	23	24	12	12	4	2	4	2	0	0.711	1.000	1.000
576	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(3), ASAH1(1), B4GALT6(1), ENPP7(4), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2), SGMS2(1), SGPP2(2), UGT8(1)	15392179	24	23	24	13	10	6	2	5	1	0	0.737	1.000	1.000
577	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(2), SRC(2)	19593032	24	23	23	13	5	5	3	7	4	0	0.903	1.000	1.000
578	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(3), CREBBP(5), DVL1(1), EP300(1), FZD1(1), GSK3B(1), PITX2(3), TRRAP(6), WNT1(1)	14169459	23	22	23	11	4	5	3	5	6	0	0.820	1.000	1.000
579	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(2), CYP3A5(5), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2)	9694850	21	21	21	10	11	1	3	4	2	0	0.581	1.000	1.000
580	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(5), SELE(2), SELP(2)	6836061	22	21	22	15	10	1	3	5	3	0	0.897	1.000	1.000
581	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(1), RELN(13)	5971112	18	18	18	10	6	2	4	2	4	0	0.729	1.000	1.000
582	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), PFKFB1(2), PFKFB4(1), PFKL(1), PFKP(1), PMM1(1)	15949760	18	17	18	12	12	1	2	2	1	0	0.891	1.000	1.000
583	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1)	15856040	17	17	15	11	8	3	0	2	4	0	0.950	1.000	1.000
584	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PFKL(1), PFKP(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1), TKTL1(1), TKTL2(1)	10388762	16	16	16	9	9	2	2	3	0	0	0.769	1.000	1.000
585	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(1), AGPAT6(1), ENPP2(4), ENPP6(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1)	9914515	16	16	16	8	9	2	0	5	0	0	0.767	1.000	1.000
586	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(5), SELE(2)	5190324	15	15	15	11	6	1	2	3	3	0	0.900	1.000	1.000
587	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(1), ITGAM(5), ITGB2(5), SELE(2)	4477355	16	15	16	12	8	0	2	3	3	0	0.915	1.000	1.000
588	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSE(3), ASAH1(1), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2)	10401098	15	14	15	10	6	3	1	4	1	0	0.887	1.000	1.000
589	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5C1B(2), NT5E(2), NUDT12(1)	9184544	14	14	13	9	5	3	3	3	0	0	0.843	1.000	1.000
590	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), SPAM1(4)	8786253	13	13	12	7	6	3	0	4	0	0	0.790	1.000	1.000
591	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PFKP(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1)	8715600	13	13	13	8	6	2	2	3	0	0	0.840	1.000	1.000
592	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), PGK1(1), PGK2(1), PKLR(1), RPE(1), TKTL1(1), TKTL2(1)	8572647	12	12	12	10	5	2	0	5	0	0	0.972	1.000	1.000
593	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), ME2(1), PGK1(1), PKLR(1), RPE(1)	7672224	10	10	10	8	3	2	0	5	0	0	0.964	1.000	1.000
594	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1)	4739470	9	9	9	5	3	3	0	3	0	0	0.804	1.000	1.000
595	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), B3GALT5(1), GBGT1(1), ST3GAL1(1), ST8SIA1(1)	4576417	6	6	6	6	1	0	0	5	0	0	0.992	1.000	1.000
596	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(1), THBS1(2)	3136131	5	5	5	4	2	1	1	1	0	0	0.869	1.000	1.000
597	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3), KDELR1(1)	6895862	4	4	4	4	1	2	0	1	0	0	0.939	1.000	1.000
598	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), PFKL(1), PGK1(1), PKLR(1)	3958078	4	4	4	3	2	0	0	2	0	0	0.904	1.000	1.000
599	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT5(1), FUT3(2)	3072845	4	4	4	3	3	0	0	1	0	0	0.869	1.000	1.000
600	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), UQCRC1(1)	2813016	3	3	3	3	0	1	1	1	0	0	0.927	1.000	1.000
601	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(1), ST3GAL1(1), ST8SIA1(1)	4313405	3	3	3	6	1	0	0	2	0	0	0.999	1.000	1.000
602	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	LCT(3)	6156493	3	3	3	6	1	1	0	1	0	0	0.996	1.000	1.000
603	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), PON1(2)	3846429	3	3	3	5	1	0	0	2	0	0	0.997	1.000	1.000
604	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAR2B(1)	4292461	2	2	2	2	0	0	0	2	0	0	0.955	1.000	1.000
605	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFA12(1), NDUFA13(1)	1731184	2	2	2	2	2	0	0	0	0	0	0.900	1.000	1.000
606	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	ESCO1(1), MYST4(1)	7057311	2	2	2	2	0	2	0	0	0	0	0.893	1.000	1.000
607	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1)	2062033	1	1	1	2	1	0	0	0	0	0	0.981	1.000	1.000
608	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(1)	2535233	1	1	1	2	1	0	0	0	0	0	0.945	1.000	1.000
609	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2670751	1	1	1	2	0	0	1	0	0	0	0.985	1.000	1.000
610	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		215272	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		951505	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1323926	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		649901	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		724867	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9		1826661	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4		1435926	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
