Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.119 0.276 0.542 16.0 -0.634 2.0 18.0 IHH 0.072 0.144 0.346 6.0 -0.67 1.0 7.0 SHH Np/Cholesterol/GAS1 -0.056 0.157 -9999.0 0.0 -0.418 9.0 9.0 LRPAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.056 0.156 0.415 9.0 -9999.0 0.0 9.0 SMO/beta Arrestin2 0.058 0.186 0.441 2.0 -0.588 3.0 5.0 SMO 0.053 0.203 0.454 3.0 -0.615 3.0 6.0 AKT1 0.047 0.134 0.327 2.0 -0.373 1.0 3.0 ARRB2 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.053 0.201 0.453 3.0 -0.604 3.0 6.0 STIL 0.087 0.207 0.513 6.0 -0.561 2.0 8.0 DHH N/PTCH2 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.08 0.193 0.447 4.0 -0.547 3.0 7.0 PIK3CA 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.133 0.313 0.625 16.0 -0.706 2.0 18.0 determination of left/right symmetry 0.053 0.201 0.453 3.0 -0.604 3.0 6.0 PIK3R1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.133 0.312 0.624 16.0 -0.699 2.0 18.0 IHH N/Hhip -0.243 0.304 -9999.0 0.0 -0.517 37.0 37.0 DHH N/Hhip -0.239 0.255 -9999.0 0.0 -0.474 37.0 37.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.053 0.201 0.453 3.0 -0.604 3.0 6.0 pancreas development -0.328 0.327 -9999.0 0.0 -0.63 37.0 37.0 HHAT 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.035 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.087 0.244 -9999.0 0.0 -0.614 12.0 12.0 somite specification 0.053 0.201 0.453 3.0 -0.604 3.0 6.0 SHH Np/Cholesterol/PTCH1 0.044 0.176 0.43 2.0 -0.455 4.0 6.0 SHH Np/Cholesterol/PTCH2 0.001 0.075 -9999.0 0.0 -0.374 2.0 2.0 SHH Np/Cholesterol/Megalin -0.071 0.17 0.228 2.0 -0.379 14.0 16.0 SHH 0.003 0.093 0.264 2.0 -0.474 2.0 4.0 catabolic process 0.089 0.234 0.423 16.0 -0.598 3.0 19.0 SMO/Vitamin D3 0.079 0.216 0.565 3.0 -0.561 3.0 6.0 SHH Np/Cholesterol/Hhip -0.184 0.199 -9999.0 0.0 -0.359 36.0 36.0 LRP2 -0.111 0.285 0.374 2.0 -0.639 15.0 17.0 receptor-mediated endocytosis -0.021 0.223 0.412 1.0 -0.576 5.0 6.0 SHH Np/Cholesterol/BOC 0.002 0.075 -9999.0 0.0 -0.374 2.0 2.0 SHH Np/Cholesterol/CDO 0.001 0.074 -9999.0 0.0 -0.368 2.0 2.0 mesenchymal cell differentiation 0.183 0.198 0.357 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 0.088 0.207 0.357 15.0 -0.457 4.0 19.0 IHH N/PTCH2 0.054 0.095 -9999.0 0.0 -0.426 1.0 1.0 CDON 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.104 0.242 0.451 16.0 -0.602 3.0 19.0 Megalin/LRPAP1 -0.071 0.219 0.265 2.0 -0.48 15.0 17.0 PTCH2 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.005 0.073 -9999.0 0.0 -0.284 4.0 4.0 PTCH1 0.09 0.235 0.424 16.0 -0.601 3.0 19.0 HHIP -0.328 0.327 -9999.0 0.0 -0.631 37.0 37.0