Ovarian Serous Cystadenocarcinoma: Correlation between copy number variation genes and molecular subtypes<BR>(primary solid tumor cohort)

Ovarian Serous Cystadenocarcinoma: Correlation between copy number variation genes and molecular subtypes
(primary solid tumor cohort)

Maintained by TCGA GDAC Team (Broad Institute/MD Anderson Cancer Center/Harvard Medical School)

Overview

Introduction

This pipeline computes the correlation between significant copy number variation (cnv) genes and molecular subtypes.

Summary

Testing the association between copy number variation of 69 peak regions and 12 molecular subtypes across 569 patients, 79 significant findings detected with Q value < 0.25.

Amp Peak 1(1p34.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 2(1q21.3) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 3(1q42.2) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 4(2p23.2) cnvs correlated to 'CN_CNMF'.
Amp Peak 5(2q31.2) cnvs correlated to 'CN_CNMF'.
Amp Peak 6(3q26.2) cnvs correlated to 'CN_CNMF'.
Amp Peak 7(4p16.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 8(4q13.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 9(5p15.33) cnvs correlated to 'CN_CNMF'.
Amp Peak 10(6p22.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 11(7q36.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 12(8p11.21) cnvs correlated to 'CN_CNMF'.
Amp Peak 13(8q24.21) cnvs correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'MRNASEQ_CNMF', and 'MRNASEQ_CHIERARCHICAL'.
Amp Peak 14(10p15.3) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 16(11q14.1) cnvs correlated to 'CN_CNMF'.
Amp Peak 17(12p13.33) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 18(12p12.1) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 20(14q32.33) cnvs correlated to 'CN_CNMF'.
Amp Peak 21(15q26.3) cnvs correlated to 'CN_CNMF'.
Amp Peak 23(18q11.2) cnvs correlated to 'CN_CNMF'.
Amp Peak 24(19p13.12) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 25(19q12) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 26(19q13.2) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 27(20p13) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 28(20q11.21) cnvs correlated to 'MRNA_CHIERARCHICAL', 'MIR_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
Amp Peak 29(20q13.33) cnvs correlated to 'MRNA_CHIERARCHICAL', 'CN_CNMF', and 'METHLYATION_CNMF'.
Amp Peak 31(Xp11.23) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Amp Peak 32(Xq28) cnvs correlated to 'CN_CNMF'.
Del Peak 1(1p36.11) cnvs correlated to 'CN_CNMF'.
Del Peak 2(1q32.3) cnvs correlated to 'CN_CNMF'.
Del Peak 5(2q37.3) cnvs correlated to 'CN_CNMF'.
Del Peak 6(3p26.2) cnvs correlated to 'MRNA_CHIERARCHICAL', 'CN_CNMF', and 'METHLYATION_CNMF'.
Del Peak 9(5q11.2) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Del Peak 10(5q13.2) cnvs correlated to 'CN_CNMF'.
Del Peak 11(6q27) cnvs correlated to 'CN_CNMF', 'METHLYATION_CNMF', and 'MRNASEQ_CNMF'.
Del Peak 12(7p22.1) cnvs correlated to 'CN_CNMF'.
Del Peak 13(8p23.3) cnvs correlated to 'CN_CNMF'.
Del Peak 14(8p21.2) cnvs correlated to 'CN_CNMF'.
Del Peak 15(9p24.3) cnvs correlated to 'MRNA_CNMF' and 'METHLYATION_CNMF'.
Del Peak 16(9q34.13) cnvs correlated to 'CN_CNMF'.
Del Peak 18(10q23.31) cnvs correlated to 'CN_CNMF'.
Del Peak 19(10q26.3) cnvs correlated to 'CN_CNMF'.
Del Peak 20(11p15.5) cnvs correlated to 'CN_CNMF'.
Del Peak 22(12q24.33) cnvs correlated to 'MRNA_CHIERARCHICAL' and 'CN_CNMF'.
Del Peak 23(13q14.2) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Del Peak 24(14q23.3) cnvs correlated to 'CN_CNMF'.
Del Peak 25(15q15.1) cnvs correlated to 'CN_CNMF' and 'METHLYATION_CNMF'.
Del Peak 27(16q22.1) cnvs correlated to 'CN_CNMF'.
Del Peak 28(16q23.1) cnvs correlated to 'CN_CNMF'.
Del Peak 34(19q13.43) cnvs correlated to 'METHLYATION_CNMF'.

Results

Overview of the results

Table 1. Get Full Table Overview of the association between significant copy number variation of 69 regions and 12 molecular subtypes. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 79 significant findings detected.


		Molecular subtypes	MRNA CNMF	MRNA CHIERARCHICAL	MIR CNMF	MIR CHIERARCHICAL	CN CNMF	METHLYATION CNMF	RPPA CNMF	RPPA CHIERARCHICAL	MRNASEQ CNMF	MRNASEQ CHIERARCHICAL	MIRSEQ CNMF	MIRSEQ CHIERARCHICAL
	nCNV (%)	nWild-Type	Fisher's exact test	Fisher's exact test	Fisher's exact test	Chi-square test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test	Fisher's exact test
Amp Peak 13(8q24 21)	447 (79%)	122	1.05e-07 (8.35e-05)	1.24e-05 (0.00966)	0.229 (1.00)	0.00313 (1.00)	2.31e-17 (1.9e-14)	0.0059 (1.00)	0.96 (1.00)	0.595 (1.00)	4.52e-07 (0.000357)	2.46e-05 (0.0191)	0.142 (1.00)	0.0406 (1.00)
Amp Peak 28(20q11 21)	332 (58%)	237	0.00553 (1.00)	3.68e-08 (2.94e-05)	0.185 (1.00)	0.000105 (0.0798)	2.61e-24 (2.16e-21)	6.61e-13 (5.43e-10)	0.14 (1.00)	0.0392 (1.00)	0.000138 (0.104)	0.599 (1.00)	0.543 (1.00)	0.251 (1.00)
Amp Peak 29(20q13 33)	392 (69%)	177	0.00761 (1.00)	3.75e-05 (0.0289)	0.599 (1.00)	0.00326 (1.00)	6.66e-18 (5.5e-15)	6.08e-08 (4.85e-05)	0.899 (1.00)	0.56 (1.00)	0.008 (1.00)	0.793 (1.00)	0.476 (1.00)	0.604 (1.00)
Del Peak 6(3p26 2)	210 (37%)	359	0.083 (1.00)	6.13e-05 (0.0469)	0.00412 (1.00)	0.0222 (1.00)	6.47e-05 (0.0494)	0.000102 (0.0778)	0.97 (1.00)	0.0949 (1.00)	0.00312 (1.00)	0.674 (1.00)	0.628 (1.00)	0.611 (1.00)
Del Peak 11(6q27)	381 (67%)	188	0.126 (1.00)	0.00186 (1.00)	0.346 (1.00)	0.0164 (1.00)	3.86e-09 (3.11e-06)	1.84e-05 (0.0143)	0.428 (1.00)	0.917 (1.00)	2.69e-05 (0.0208)	0.25 (1.00)	0.457 (1.00)	0.945 (1.00)
Amp Peak 2(1q21 3)	356 (63%)	213	0.211 (1.00)	0.0621 (1.00)	0.687 (1.00)	0.15 (1.00)	1.52e-11 (1.24e-08)	0.000204 (0.154)	0.0601 (1.00)	0.00999 (1.00)	0.628 (1.00)	0.28 (1.00)	0.916 (1.00)	0.972 (1.00)
Amp Peak 3(1q42 2)	312 (55%)	257	0.023 (1.00)	0.0325 (1.00)	0.941 (1.00)	0.0063 (1.00)	5.98e-09 (4.81e-06)	4.9e-05 (0.0377)	0.279 (1.00)	0.207 (1.00)	0.62 (1.00)	0.418 (1.00)	0.183 (1.00)	0.27 (1.00)
Amp Peak 14(10p15 3)	241 (42%)	328	0.758 (1.00)	0.092 (1.00)	0.0698 (1.00)	0.255 (1.00)	2.5e-12 (2.05e-09)	0.000103 (0.0781)	0.562 (1.00)	0.408 (1.00)	0.344 (1.00)	0.306 (1.00)	0.465 (1.00)	0.945 (1.00)
Amp Peak 17(12p13 33)	318 (56%)	251	0.0361 (1.00)	0.00326 (1.00)	0.29 (1.00)	0.0108 (1.00)	9.98e-11 (8.08e-08)	1.28e-05 (0.00998)	0.314 (1.00)	0.614 (1.00)	0.0124 (1.00)	0.137 (1.00)	0.32 (1.00)	0.921 (1.00)
Amp Peak 18(12p12 1)	301 (53%)	268	0.273 (1.00)	0.013 (1.00)	0.843 (1.00)	0.0968 (1.00)	1.63e-13 (1.35e-10)	2.27e-06 (0.00179)	0.819 (1.00)	0.493 (1.00)	0.0214 (1.00)	0.133 (1.00)	0.202 (1.00)	0.7 (1.00)
Amp Peak 24(19p13 12)	306 (54%)	263	0.000624 (0.465)	0.000463 (0.347)	0.0461 (1.00)	0.052 (1.00)	1.02e-13 (8.42e-11)	4.2e-06 (0.0033)	0.000662 (0.492)	0.00378 (1.00)	0.215 (1.00)	0.27 (1.00)	0.482 (1.00)	0.595 (1.00)
Amp Peak 25(19q12)	314 (55%)	255	0.0736 (1.00)	0.0235 (1.00)	0.0402 (1.00)	0.147 (1.00)	2.25e-29 (1.86e-26)	1.06e-10 (8.58e-08)	0.0803 (1.00)	0.82 (1.00)	0.551 (1.00)	0.86 (1.00)	0.335 (1.00)	0.596 (1.00)
Amp Peak 26(19q13 2)	238 (42%)	331	0.957 (1.00)	0.0425 (1.00)	0.654 (1.00)	0.307 (1.00)	6.2e-12 (5.07e-09)	5.37e-05 (0.0411)	0.457 (1.00)	0.382 (1.00)	0.458 (1.00)	0.985 (1.00)	1 (1.00)	0.379 (1.00)
Amp Peak 27(20p13)	310 (54%)	259	0.465 (1.00)	0.00236 (1.00)	0.133 (1.00)	0.0302 (1.00)	1.43e-11 (1.16e-08)	8.42e-06 (0.00659)	0.321 (1.00)	0.971 (1.00)	0.0716 (1.00)	0.686 (1.00)	0.242 (1.00)	0.896 (1.00)
Amp Peak 31(Xp11 23)	163 (29%)	406	0.759 (1.00)	0.257 (1.00)	0.298 (1.00)	0.308 (1.00)	7.15e-06 (0.00561)	2.42e-05 (0.0187)	0.703 (1.00)	0.222 (1.00)	0.286 (1.00)	0.216 (1.00)	0.365 (1.00)	0.879 (1.00)
Del Peak 9(5q11 2)	341 (60%)	228	0.694 (1.00)	0.144 (1.00)	0.425 (1.00)	0.206 (1.00)	4.69e-08 (3.75e-05)	0.00021 (0.158)	0.731 (1.00)	0.852 (1.00)	0.182 (1.00)	0.128 (1.00)	0.0341 (1.00)	0.000558 (0.417)
Del Peak 15(9p24 3)	255 (45%)	314	0.000117 (0.0886)	0.0803 (1.00)	0.772 (1.00)	0.00914 (1.00)	0.0217 (1.00)	0.000244 (0.183)	0.452 (1.00)	0.597 (1.00)	0.0726 (1.00)	0.0746 (1.00)	0.0879 (1.00)	0.137 (1.00)
Del Peak 22(12q24 33)	217 (38%)	352	0.00195 (1.00)	2.63e-06 (0.00207)	0.216 (1.00)	0.0891 (1.00)	4.83e-10 (3.91e-07)	0.0423 (1.00)	0.381 (1.00)	0.502 (1.00)	0.07 (1.00)	0.00314 (1.00)	0.0172 (1.00)	0.00569 (1.00)
Del Peak 23(13q14 2)	355 (62%)	214	0.0259 (1.00)	0.516 (1.00)	0.723 (1.00)	0.683 (1.00)	1.29e-06 (0.00102)	9.52e-06 (0.00745)	0.0014 (1.00)	0.000807 (0.597)	0.0989 (1.00)	0.25 (1.00)	0.375 (1.00)	0.891 (1.00)
Del Peak 25(15q15 1)	357 (63%)	212	0.0423 (1.00)	0.000469 (0.351)	0.0111 (1.00)	0.00626 (1.00)	2.28e-11 (1.85e-08)	6.14e-05 (0.0469)	0.121 (1.00)	0.0456 (1.00)	0.018 (1.00)	0.768 (1.00)	0.464 (1.00)	0.676 (1.00)
Amp Peak 1(1p34 3)	282 (50%)	287	0.179 (1.00)	0.84 (1.00)	0.148 (1.00)	0.134 (1.00)	2.72e-06 (0.00214)	0.141 (1.00)	0.121 (1.00)	0.784 (1.00)	0.602 (1.00)	0.104 (1.00)	0.0694 (1.00)	0.0922 (1.00)
Amp Peak 4(2p23 2)	239 (42%)	330	0.341 (1.00)	0.0263 (1.00)	0.582 (1.00)	0.0135 (1.00)	5.72e-09 (4.6e-06)	0.00424 (1.00)	0.223 (1.00)	0.658 (1.00)	0.0316 (1.00)	0.751 (1.00)	0.911 (1.00)	0.115 (1.00)
Amp Peak 5(2q31 2)	250 (44%)	319	0.0779 (1.00)	0.00222 (1.00)	0.0744 (1.00)	0.052 (1.00)	2.18e-11 (1.78e-08)	0.00187 (1.00)	0.0575 (1.00)	0.507 (1.00)	0.229 (1.00)	0.522 (1.00)	0.456 (1.00)	0.664 (1.00)
Amp Peak 6(3q26 2)	473 (83%)	96	0.0119 (1.00)	0.00228 (1.00)	0.907 (1.00)	0.438 (1.00)	2.9e-11 (2.35e-08)	0.0338 (1.00)	0.554 (1.00)	0.553 (1.00)	0.0166 (1.00)	0.0463 (1.00)	0.123 (1.00)	0.432 (1.00)
Amp Peak 7(4p16 3)	156 (27%)	413	0.955 (1.00)	0.0338 (1.00)	0.0518 (1.00)	0.694 (1.00)	4.24e-05 (0.0327)	0.00917 (1.00)	0.244 (1.00)	0.769 (1.00)	0.75 (1.00)	0.455 (1.00)	0.644 (1.00)	0.664 (1.00)
Amp Peak 8(4q13 3)	106 (19%)	463	0.914 (1.00)	0.133 (1.00)	0.354 (1.00)	0.175 (1.00)	1.06e-05 (0.00831)	0.174 (1.00)	0.312 (1.00)	0.149 (1.00)	0.148 (1.00)	0.935 (1.00)	0.976 (1.00)	0.108 (1.00)
Amp Peak 9(5p15 33)	299 (53%)	270	0.884 (1.00)	0.485 (1.00)	0.625 (1.00)	0.54 (1.00)	1.33e-07 (0.000106)	0.186 (1.00)	0.982 (1.00)	0.477 (1.00)	0.175 (1.00)	0.927 (1.00)	0.0138 (1.00)	0.436 (1.00)
Amp Peak 10(6p22 3)	291 (51%)	278	0.132 (1.00)	0.0154 (1.00)	0.249 (1.00)	0.156 (1.00)	1.59e-08 (1.27e-05)	0.0408 (1.00)	0.0709 (1.00)	0.053 (1.00)	0.833 (1.00)	0.0709 (1.00)	0.304 (1.00)	0.434 (1.00)
Amp Peak 11(7q36 3)	304 (53%)	265	0.0439 (1.00)	0.515 (1.00)	0.262 (1.00)	0.588 (1.00)	1.25e-05 (0.00976)	0.2 (1.00)	0.0683 (1.00)	0.242 (1.00)	0.962 (1.00)	0.764 (1.00)	0.165 (1.00)	0.143 (1.00)
Amp Peak 12(8p11 21)	202 (36%)	367	0.105 (1.00)	0.00242 (1.00)	0.102 (1.00)	0.292 (1.00)	3.5e-07 (0.000277)	0.00506 (1.00)	0.0365 (1.00)	0.262 (1.00)	0.352 (1.00)	0.216 (1.00)	0.905 (1.00)	0.672 (1.00)
Amp Peak 16(11q14 1)	251 (44%)	318	0.00682 (1.00)	0.0904 (1.00)	0.847 (1.00)	0.294 (1.00)	5.31e-09 (4.27e-06)	0.0128 (1.00)	0.6 (1.00)	0.222 (1.00)	0.00378 (1.00)	0.00405 (1.00)	0.205 (1.00)	0.827 (1.00)
Amp Peak 20(14q32 33)	151 (27%)	418	0.329 (1.00)	0.14 (1.00)	0.198 (1.00)	0.823 (1.00)	0.000278 (0.209)	0.306 (1.00)	1 (1.00)	0.671 (1.00)	0.185 (1.00)	0.578 (1.00)	0.508 (1.00)	0.78 (1.00)
Amp Peak 21(15q26 3)	157 (28%)	412	0.0786 (1.00)	0.955 (1.00)	0.503 (1.00)	0.689 (1.00)	2.42e-09 (1.96e-06)	0.64 (1.00)	0.978 (1.00)	0.253 (1.00)	0.157 (1.00)	0.945 (1.00)	0.119 (1.00)	0.363 (1.00)
Amp Peak 23(18q11 2)	139 (24%)	430	0.952 (1.00)	0.198 (1.00)	0.976 (1.00)	0.527 (1.00)	3.4e-07 (0.00027)	0.00127 (0.932)	0.205 (1.00)	0.453 (1.00)	0.0427 (1.00)	0.109 (1.00)	0.313 (1.00)	0.825 (1.00)
Amp Peak 32(Xq28)	224 (39%)	345	0.241 (1.00)	0.392 (1.00)	0.832 (1.00)	0.117 (1.00)	4.73e-05 (0.0364)	0.13 (1.00)	0.359 (1.00)	0.791 (1.00)	0.549 (1.00)	0.435 (1.00)	0.917 (1.00)	0.0119 (1.00)
Del Peak 1(1p36 11)	265 (47%)	304	0.952 (1.00)	0.804 (1.00)	0.0385 (1.00)	0.326 (1.00)	1.88e-06 (0.00148)	0.15 (1.00)	0.189 (1.00)	0.416 (1.00)	0.961 (1.00)	0.807 (1.00)	0.221 (1.00)	0.144 (1.00)
Del Peak 2(1q32 3)	95 (17%)	474	0.0848 (1.00)	0.518 (1.00)	0.477 (1.00)	0.11 (1.00)	3.05e-07 (0.000242)	0.342 (1.00)	0.781 (1.00)	0.105 (1.00)	0.115 (1.00)	0.33 (1.00)	0.897 (1.00)	0.57 (1.00)
Del Peak 5(2q37 3)	174 (31%)	395	0.0103 (1.00)	0.000801 (0.593)	0.612 (1.00)	0.0017 (1.00)	3.6e-05 (0.0278)	0.065 (1.00)	0.725 (1.00)	0.894 (1.00)	0.0199 (1.00)	0.0289 (1.00)	0.0187 (1.00)	0.0125 (1.00)
Del Peak 10(5q13 2)	406 (71%)	163	0.702 (1.00)	0.738 (1.00)	0.888 (1.00)	0.809 (1.00)	2.07e-12 (1.7e-09)	0.0438 (1.00)	0.762 (1.00)	0.824 (1.00)	0.354 (1.00)	0.00303 (1.00)	0.121 (1.00)	0.00885 (1.00)
Del Peak 12(7p22 1)	247 (43%)	322	0.569 (1.00)	0.0224 (1.00)	0.678 (1.00)	0.66 (1.00)	2.78e-13 (2.28e-10)	0.821 (1.00)	0.801 (1.00)	0.782 (1.00)	0.282 (1.00)	0.104 (1.00)	0.328 (1.00)	0.564 (1.00)
Del Peak 13(8p23 3)	381 (67%)	188	0.0571 (1.00)	0.00845 (1.00)	0.629 (1.00)	0.0185 (1.00)	1.1e-11 (9e-09)	0.0386 (1.00)	0.873 (1.00)	0.616 (1.00)	0.895 (1.00)	0.6 (1.00)	0.235 (1.00)	0.159 (1.00)
Del Peak 14(8p21 2)	398 (70%)	171	0.0388 (1.00)	0.0146 (1.00)	0.233 (1.00)	0.00956 (1.00)	1.1e-08 (8.84e-06)	0.29 (1.00)	0.794 (1.00)	0.848 (1.00)	0.36 (1.00)	0.25 (1.00)	0.541 (1.00)	0.484 (1.00)
Del Peak 16(9q34 13)	337 (59%)	232	0.0193 (1.00)	0.0144 (1.00)	1 (1.00)	0.0188 (1.00)	2.94e-07 (0.000234)	0.0331 (1.00)	0.344 (1.00)	0.371 (1.00)	0.272 (1.00)	1 (1.00)	0.0371 (1.00)	0.0995 (1.00)
Del Peak 18(10q23 31)	220 (39%)	349	0.238 (1.00)	0.981 (1.00)	0.000556 (0.415)	0.0125 (1.00)	0.000247 (0.186)	0.00112 (0.825)	0.036 (1.00)	0.0121 (1.00)	0.961 (1.00)	0.502 (1.00)	0.0735 (1.00)	0.383 (1.00)
Del Peak 19(10q26 3)	189 (33%)	380	0.00841 (1.00)	0.0553 (1.00)	0.25 (1.00)	0.405 (1.00)	1.08e-05 (0.00842)	0.0936 (1.00)	0.0924 (1.00)	0.0135 (1.00)	0.0603 (1.00)	0.122 (1.00)	0.0163 (1.00)	0.221 (1.00)
Del Peak 20(11p15 5)	338 (59%)	231	0.0499 (1.00)	0.306 (1.00)	0.729 (1.00)	0.0477 (1.00)	6.76e-12 (5.52e-09)	0.00987 (1.00)	0.963 (1.00)	0.596 (1.00)	0.717 (1.00)	0.272 (1.00)	0.129 (1.00)	0.024 (1.00)
Del Peak 24(14q23 3)	298 (52%)	271	0.072 (1.00)	0.607 (1.00)	0.828 (1.00)	0.854 (1.00)	0.000143 (0.108)	0.388 (1.00)	0.185 (1.00)	0.247 (1.00)	0.856 (1.00)	0.201 (1.00)	0.803 (1.00)	0.662 (1.00)
Del Peak 27(16q22 1)	451 (79%)	118	0.363 (1.00)	0.319 (1.00)	0.0303 (1.00)	0.925 (1.00)	0.000316 (0.237)	0.392 (1.00)	0.552 (1.00)	0.359 (1.00)	0.303 (1.00)	0.305 (1.00)	0.412 (1.00)	0.126 (1.00)
Del Peak 28(16q23 1)	442 (78%)	127	0.11 (1.00)	0.105 (1.00)	0.143 (1.00)	0.32 (1.00)	5.1e-05 (0.0391)	0.373 (1.00)	0.602 (1.00)	0.925 (1.00)	0.395 (1.00)	0.449 (1.00)	0.0892 (1.00)	0.0393 (1.00)
Del Peak 34(19q13 43)	280 (49%)	289	0.0138 (1.00)	0.0517 (1.00)	0.0789 (1.00)	0.157 (1.00)	0.000816 (0.603)	6.49e-05 (0.0495)	0.178 (1.00)	0.278 (1.00)	0.555 (1.00)	0.154 (1.00)	0.527 (1.00)	0.455 (1.00)
Amp Peak 15(10q22 3)	176 (31%)	393	0.443 (1.00)	0.327 (1.00)	0.607 (1.00)	0.0601 (1.00)	0.285 (1.00)	0.89 (1.00)	0.527 (1.00)	0.978 (1.00)	0.0749 (1.00)	0.332 (1.00)	0.112 (1.00)	0.151 (1.00)
Amp Peak 19(14q11 2)	144 (25%)	425	0.00478 (1.00)	0.0765 (1.00)	0.323 (1.00)	0.00145 (1.00)	0.0393 (1.00)	0.166 (1.00)	0.393 (1.00)	0.288 (1.00)	0.255 (1.00)	0.333 (1.00)	0.234 (1.00)	0.335 (1.00)
Amp Peak 22(17q25 3)	207 (36%)	362	0.453 (1.00)	0.261 (1.00)	0.913 (1.00)	0.123 (1.00)	0.00573 (1.00)	0.927 (1.00)	0.0936 (1.00)	0.112 (1.00)	0.0162 (1.00)	0.0241 (1.00)	0.406 (1.00)	0.169 (1.00)
Amp Peak 30(22q12 2)	88 (15%)	481	0.602 (1.00)	0.739 (1.00)	0.0836 (1.00)	0.359 (1.00)	0.00187 (1.00)	0.00125 (0.919)	1 (1.00)	0.0575 (1.00)	0.0986 (1.00)	0.195 (1.00)	0.101 (1.00)	0.0114 (1.00)
Del Peak 3(2p25 3)	118 (21%)	451	0.973 (1.00)	0.982 (1.00)	0.454 (1.00)	0.489 (1.00)	0.345 (1.00)	0.522 (1.00)	0.149 (1.00)	0.112 (1.00)	0.0501 (1.00)	0.734 (1.00)	0.905 (1.00)	0.506 (1.00)
Del Peak 4(2q22 1)	134 (24%)	435	0.0722 (1.00)	0.13 (1.00)	0.867 (1.00)	0.15 (1.00)	0.0327 (1.00)	0.199 (1.00)	0.281 (1.00)	0.71 (1.00)	0.983 (1.00)	0.357 (1.00)	0.567 (1.00)	0.574 (1.00)
Del Peak 7(4q22 1)	383 (67%)	186	0.0283 (1.00)	0.328 (1.00)	0.927 (1.00)	0.00966 (1.00)	0.0751 (1.00)	0.507 (1.00)	0.0593 (1.00)	0.00908 (1.00)	0.109 (1.00)	0.424 (1.00)	0.195 (1.00)	0.00733 (1.00)
Del Peak 8(4q34 3)	412 (72%)	157	0.0165 (1.00)	0.135 (1.00)	0.0222 (1.00)	0.0134 (1.00)	0.283 (1.00)	0.514 (1.00)	0.429 (1.00)	0.211 (1.00)	0.0851 (1.00)	0.0303 (1.00)	0.337 (1.00)	0.177 (1.00)
Del Peak 17(10p15 3)	121 (21%)	448	0.138 (1.00)	0.0407 (1.00)	0.0968 (1.00)	0.0865 (1.00)	0.0721 (1.00)	0.414 (1.00)	0.283 (1.00)	0.0688 (1.00)	0.0145 (1.00)	0.0607 (1.00)	0.255 (1.00)	0.338 (1.00)
Del Peak 21(11q25)	195 (34%)	374	0.81 (1.00)	0.211 (1.00)	0.175 (1.00)	0.38 (1.00)	0.0957 (1.00)	0.463 (1.00)	0.32 (1.00)	0.175 (1.00)	0.931 (1.00)	0.877 (1.00)	0.597 (1.00)	0.138 (1.00)
Del Peak 26(16p13 3)	303 (53%)	266	0.542 (1.00)	0.0773 (1.00)	0.167 (1.00)	0.462 (1.00)	0.062 (1.00)	0.592 (1.00)	0.921 (1.00)	0.239 (1.00)	0.508 (1.00)	0.786 (1.00)	0.204 (1.00)	0.852 (1.00)
Del Peak 29(17p12)	481 (85%)	88	0.322 (1.00)	0.719 (1.00)	0.619 (1.00)	0.591 (1.00)	0.936 (1.00)	0.396 (1.00)	0.938 (1.00)	0.362 (1.00)	0.187 (1.00)	0.515 (1.00)	0.61 (1.00)	0.621 (1.00)
Del Peak 30(17q11 2)	466 (82%)	103	0.95 (1.00)	0.0627 (1.00)	0.735 (1.00)	0.477 (1.00)	0.000626 (0.465)	0.000996 (0.735)	0.767 (1.00)	0.0666 (1.00)	0.377 (1.00)	0.571 (1.00)	0.202 (1.00)	0.565 (1.00)
Del Peak 31(18q23)	373 (66%)	196	0.934 (1.00)	0.842 (1.00)	0.188 (1.00)	0.434 (1.00)	0.00594 (1.00)	0.447 (1.00)	0.228 (1.00)	0.275 (1.00)	0.22 (1.00)	0.398 (1.00)	0.689 (1.00)	0.689 (1.00)
Del Peak 32(19p13 3)	502 (88%)	67	0.257 (1.00)	0.00399 (1.00)	0.943 (1.00)	0.462 (1.00)	0.00124 (0.911)	0.0186 (1.00)	0.592 (1.00)	0.229 (1.00)	0.333 (1.00)	0.0157 (1.00)	0.476 (1.00)	0.85 (1.00)
Del Peak 33(19q13 33)	295 (52%)	274	0.000675 (0.501)	0.0101 (1.00)	0.0634 (1.00)	0.138 (1.00)	0.0286 (1.00)	0.00235 (1.00)	0.0342 (1.00)	0.214 (1.00)	0.00784 (1.00)	0.0844 (1.00)	0.259 (1.00)	0.151 (1.00)
Del Peak 35(21q22 3)	221 (39%)	348	0.235 (1.00)	0.359 (1.00)	0.705 (1.00)	0.241 (1.00)	0.783 (1.00)	0.347 (1.00)	0.579 (1.00)	0.626 (1.00)	0.189 (1.00)	0.272 (1.00)	0.74 (1.00)	0.652 (1.00)
Del Peak 36(22q13 32)	493 (87%)	76	0.125 (1.00)	0.0621 (1.00)	0.0229 (1.00)	0.0717 (1.00)	0.00805 (1.00)	0.093 (1.00)	0.0711 (1.00)	0.349 (1.00)	0.068 (1.00)	0.18 (1.00)	0.0236 (1.00)	0.296 (1.00)
Del Peak 37(Xp21 1)	364 (64%)	205	0.296 (1.00)	0.98 (1.00)	0.12 (1.00)	0.643 (1.00)	0.1 (1.00)	0.0218 (1.00)	0.323 (1.00)	0.0434 (1.00)	0.908 (1.00)	0.409 (1.00)	0.936 (1.00)	0.43 (1.00)

'Amp Peak 1(1p34.3) mutation analysis' versus 'CN_CNMF'

P value = 2.72e-06 (Fisher's exact test), Q value = 0.0021

Table S1. Gene #1: 'Amp Peak 1(1p34.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 1(1P34.3) MUTATED	55	114	113
AMP PEAK 1(1P34.3) WILD-TYPE	111	90	86

Figure S1. Get High-res Image Gene #1: 'Amp Peak 1(1p34.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 2(1q21.3) mutation analysis' versus 'CN_CNMF'

P value = 1.52e-11 (Fisher's exact test), Q value = 1.2e-08

Table S2. Gene #2: 'Amp Peak 2(1q21.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 2(1Q21.3) MUTATED	83	111	162
AMP PEAK 2(1Q21.3) WILD-TYPE	83	93	37

Figure S2. Get High-res Image Gene #2: 'Amp Peak 2(1q21.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 2(1q21.3) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000204 (Fisher's exact test), Q value = 0.15

Table S3. Gene #2: 'Amp Peak 2(1q21.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 2(1Q21.3) MUTATED	125	91	140
AMP PEAK 2(1Q21.3) WILD-TYPE	46	85	81

Figure S3. Get High-res Image Gene #2: 'Amp Peak 2(1q21.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 3(1q42.2) mutation analysis' versus 'CN_CNMF'

P value = 5.98e-09 (Fisher's exact test), Q value = 4.8e-06

Table S4. Gene #3: 'Amp Peak 3(1q42.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 3(1Q42.2) MUTATED	85	85	142
AMP PEAK 3(1Q42.2) WILD-TYPE	81	119	57

Figure S4. Get High-res Image Gene #3: 'Amp Peak 3(1q42.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 3(1q42.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 4.9e-05 (Fisher's exact test), Q value = 0.038

Table S5. Gene #3: 'Amp Peak 3(1q42.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 3(1Q42.2) MUTATED	118	86	108
AMP PEAK 3(1Q42.2) WILD-TYPE	53	90	113

Figure S5. Get High-res Image Gene #3: 'Amp Peak 3(1q42.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 4(2p23.2) mutation analysis' versus 'CN_CNMF'

P value = 5.72e-09 (Fisher's exact test), Q value = 4.6e-06

Table S6. Gene #4: 'Amp Peak 4(2p23.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 4(2P23.2) MUTATED	41	86	112
AMP PEAK 4(2P23.2) WILD-TYPE	125	118	87

Figure S6. Get High-res Image Gene #4: 'Amp Peak 4(2p23.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 5(2q31.2) mutation analysis' versus 'CN_CNMF'

P value = 2.18e-11 (Fisher's exact test), Q value = 1.8e-08

Table S7. Gene #5: 'Amp Peak 5(2q31.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 5(2Q31.2) MUTATED	37	100	113
AMP PEAK 5(2Q31.2) WILD-TYPE	129	104	86

Figure S7. Get High-res Image Gene #5: 'Amp Peak 5(2q31.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 6(3q26.2) mutation analysis' versus 'CN_CNMF'

P value = 2.9e-11 (Fisher's exact test), Q value = 2.4e-08

Table S8. Gene #6: 'Amp Peak 6(3q26.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 6(3Q26.2) MUTATED	110	177	186
AMP PEAK 6(3Q26.2) WILD-TYPE	56	27	13

Figure S8. Get High-res Image Gene #6: 'Amp Peak 6(3q26.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 7(4p16.3) mutation analysis' versus 'CN_CNMF'

P value = 4.24e-05 (Fisher's exact test), Q value = 0.033

Table S9. Gene #7: 'Amp Peak 7(4p16.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 7(4P16.3) MUTATED	30	78	48
AMP PEAK 7(4P16.3) WILD-TYPE	136	126	151

Figure S9. Get High-res Image Gene #7: 'Amp Peak 7(4p16.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 8(4q13.3) mutation analysis' versus 'CN_CNMF'

P value = 1.06e-05 (Fisher's exact test), Q value = 0.0083

Table S10. Gene #8: 'Amp Peak 8(4q13.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 8(4Q13.3) MUTATED	13	54	39
AMP PEAK 8(4Q13.3) WILD-TYPE	153	150	160

Figure S10. Get High-res Image Gene #8: 'Amp Peak 8(4q13.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 9(5p15.33) mutation analysis' versus 'CN_CNMF'

P value = 1.33e-07 (Fisher's exact test), Q value = 0.00011

Table S11. Gene #9: 'Amp Peak 9(5p15.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 9(5P15.33) MUTATED	57	120	122
AMP PEAK 9(5P15.33) WILD-TYPE	109	84	77

Figure S11. Get High-res Image Gene #9: 'Amp Peak 9(5p15.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 10(6p22.3) mutation analysis' versus 'CN_CNMF'

P value = 1.59e-08 (Fisher's exact test), Q value = 1.3e-05

Table S12. Gene #10: 'Amp Peak 10(6p22.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 10(6P22.3) MUTATED	53	125	113
AMP PEAK 10(6P22.3) WILD-TYPE	113	79	86

Figure S12. Get High-res Image Gene #10: 'Amp Peak 10(6p22.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 11(7q36.3) mutation analysis' versus 'CN_CNMF'

P value = 1.25e-05 (Fisher's exact test), Q value = 0.0098

Table S13. Gene #11: 'Amp Peak 11(7q36.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 11(7Q36.3) MUTATED	63	121	120
AMP PEAK 11(7Q36.3) WILD-TYPE	103	83	79

Figure S13. Get High-res Image Gene #11: 'Amp Peak 11(7q36.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 12(8p11.21) mutation analysis' versus 'CN_CNMF'

P value = 3.5e-07 (Fisher's exact test), Q value = 0.00028

Table S14. Gene #12: 'Amp Peak 12(8p11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 12(8P11.21) MUTATED	36	69	97
AMP PEAK 12(8P11.21) WILD-TYPE	130	135	102

Figure S14. Get High-res Image Gene #12: 'Amp Peak 12(8p11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNA_CNMF'

P value = 1.05e-07 (Fisher's exact test), Q value = 8.3e-05

Table S15. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	215	213	129
AMP PEAK 13(8Q24.21) MUTATED	142	183	113
AMP PEAK 13(8Q24.21) WILD-TYPE	73	30	16

Figure S15. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 1.24e-05 (Fisher's exact test), Q value = 0.0097

Table S16. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	233	199	125
AMP PEAK 13(8Q24.21) MUTATED	205	140	93
AMP PEAK 13(8Q24.21) WILD-TYPE	28	59	32

Figure S16. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 13(8q24.21) mutation analysis' versus 'CN_CNMF'

P value = 2.31e-17 (Fisher's exact test), Q value = 1.9e-14

Table S17. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 13(8Q24.21) MUTATED	108	197	142
AMP PEAK 13(8Q24.21) WILD-TYPE	58	7	57

Figure S17. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNASEQ_CNMF'

P value = 4.52e-07 (Fisher's exact test), Q value = 0.00036

Table S18. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	100	67	91
AMP PEAK 13(8Q24.21) MUTATED	90	61	56
AMP PEAK 13(8Q24.21) WILD-TYPE	10	6	35

Figure S18. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

'Amp Peak 13(8q24.21) mutation analysis' versus 'MRNASEQ_CHIERARCHICAL'

P value = 2.46e-05 (Fisher's exact test), Q value = 0.019

Table S19. Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #10: 'MRNASEQ_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	110	110	38
AMP PEAK 13(8Q24.21) MUTATED	74	97	36
AMP PEAK 13(8Q24.21) WILD-TYPE	36	13	2

Figure S19. Get High-res Image Gene #13: 'Amp Peak 13(8q24.21) mutation analysis' versus Clinical Feature #10: 'MRNASEQ_CHIERARCHICAL'

'Amp Peak 14(10p15.3) mutation analysis' versus 'CN_CNMF'

P value = 2.5e-12 (Fisher's exact test), Q value = 2.1e-09

Table S20. Gene #14: 'Amp Peak 14(10p15.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 14(10P15.3) MUTATED	44	73	124
AMP PEAK 14(10P15.3) WILD-TYPE	122	131	75

Figure S20. Get High-res Image Gene #14: 'Amp Peak 14(10p15.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 14(10p15.3) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000103 (Fisher's exact test), Q value = 0.078

Table S21. Gene #14: 'Amp Peak 14(10p15.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 14(10P15.3) MUTATED	95	60	85
AMP PEAK 14(10P15.3) WILD-TYPE	76	116	136

Figure S21. Get High-res Image Gene #14: 'Amp Peak 14(10p15.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 16(11q14.1) mutation analysis' versus 'CN_CNMF'

P value = 5.31e-09 (Fisher's exact test), Q value = 4.3e-06

Table S22. Gene #16: 'Amp Peak 16(11q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 16(11Q14.1) MUTATED	46	121	84
AMP PEAK 16(11Q14.1) WILD-TYPE	120	83	115

Figure S22. Get High-res Image Gene #16: 'Amp Peak 16(11q14.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 17(12p13.33) mutation analysis' versus 'CN_CNMF'

P value = 9.98e-11 (Fisher's exact test), Q value = 8.1e-08

Table S23. Gene #17: 'Amp Peak 17(12p13.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 17(12P13.33) MUTATED	63	110	145
AMP PEAK 17(12P13.33) WILD-TYPE	103	94	54

Figure S23. Get High-res Image Gene #17: 'Amp Peak 17(12p13.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 17(12p13.33) mutation analysis' versus 'METHLYATION_CNMF'

P value = 1.28e-05 (Fisher's exact test), Q value = 0.01

Table S24. Gene #17: 'Amp Peak 17(12p13.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 17(12P13.33) MUTATED	120	95	103
AMP PEAK 17(12P13.33) WILD-TYPE	51	81	118

Figure S24. Get High-res Image Gene #17: 'Amp Peak 17(12p13.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 18(12p12.1) mutation analysis' versus 'CN_CNMF'

P value = 1.63e-13 (Fisher's exact test), Q value = 1.3e-10

Table S25. Gene #18: 'Amp Peak 18(12p12.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 18(12P12.1) MUTATED	58	97	146
AMP PEAK 18(12P12.1) WILD-TYPE	108	107	53

Figure S25. Get High-res Image Gene #18: 'Amp Peak 18(12p12.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 18(12p12.1) mutation analysis' versus 'METHLYATION_CNMF'

P value = 2.27e-06 (Fisher's exact test), Q value = 0.0018

Table S26. Gene #18: 'Amp Peak 18(12p12.1) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 18(12P12.1) MUTATED	118	84	99
AMP PEAK 18(12P12.1) WILD-TYPE	53	92	122

Figure S26. Get High-res Image Gene #18: 'Amp Peak 18(12p12.1) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 20(14q32.33) mutation analysis' versus 'CN_CNMF'

P value = 0.000278 (Fisher's exact test), Q value = 0.21

Table S27. Gene #20: 'Amp Peak 20(14q32.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 20(14Q32.33) MUTATED	44	72	35
AMP PEAK 20(14Q32.33) WILD-TYPE	122	132	164

Figure S27. Get High-res Image Gene #20: 'Amp Peak 20(14q32.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 21(15q26.3) mutation analysis' versus 'CN_CNMF'

P value = 2.42e-09 (Fisher's exact test), Q value = 2e-06

Table S28. Gene #21: 'Amp Peak 21(15q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 21(15Q26.3) MUTATED	30	89	38
AMP PEAK 21(15Q26.3) WILD-TYPE	136	115	161

Figure S28. Get High-res Image Gene #21: 'Amp Peak 21(15q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 23(18q11.2) mutation analysis' versus 'CN_CNMF'

P value = 3.4e-07 (Fisher's exact test), Q value = 0.00027

Table S29. Gene #23: 'Amp Peak 23(18q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 23(18Q11.2) MUTATED	22	43	74
AMP PEAK 23(18Q11.2) WILD-TYPE	144	161	125

Figure S29. Get High-res Image Gene #23: 'Amp Peak 23(18q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 24(19p13.12) mutation analysis' versus 'CN_CNMF'

P value = 1.02e-13 (Fisher's exact test), Q value = 8.4e-11

Table S30. Gene #24: 'Amp Peak 24(19p13.12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 24(19P13.12) MUTATED	67	89	150
AMP PEAK 24(19P13.12) WILD-TYPE	99	115	49

Figure S30. Get High-res Image Gene #24: 'Amp Peak 24(19p13.12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 24(19p13.12) mutation analysis' versus 'METHLYATION_CNMF'

P value = 4.2e-06 (Fisher's exact test), Q value = 0.0033

Table S31. Gene #24: 'Amp Peak 24(19p13.12) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 24(19P13.12) MUTATED	116	73	116
AMP PEAK 24(19P13.12) WILD-TYPE	55	103	105

Figure S31. Get High-res Image Gene #24: 'Amp Peak 24(19p13.12) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 25(19q12) mutation analysis' versus 'CN_CNMF'

P value = 2.25e-29 (Fisher's exact test), Q value = 1.9e-26

Table S32. Gene #25: 'Amp Peak 25(19q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 25(19Q12) MUTATED	60	82	172
AMP PEAK 25(19Q12) WILD-TYPE	106	122	27

Figure S32. Get High-res Image Gene #25: 'Amp Peak 25(19q12) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 25(19q12) mutation analysis' versus 'METHLYATION_CNMF'

P value = 1.06e-10 (Fisher's exact test), Q value = 8.6e-08

Table S33. Gene #25: 'Amp Peak 25(19q12) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 25(19Q12) MUTATED	127	68	119
AMP PEAK 25(19Q12) WILD-TYPE	44	108	102

Figure S33. Get High-res Image Gene #25: 'Amp Peak 25(19q12) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 26(19q13.2) mutation analysis' versus 'CN_CNMF'

P value = 6.2e-12 (Fisher's exact test), Q value = 5.1e-09

Table S34. Gene #26: 'Amp Peak 26(19q13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 26(19Q13.2) MUTATED	46	69	123
AMP PEAK 26(19Q13.2) WILD-TYPE	120	135	76

Figure S34. Get High-res Image Gene #26: 'Amp Peak 26(19q13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 26(19q13.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 5.37e-05 (Fisher's exact test), Q value = 0.041

Table S35. Gene #26: 'Amp Peak 26(19q13.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 26(19Q13.2) MUTATED	94	56	88
AMP PEAK 26(19Q13.2) WILD-TYPE	77	120	133

Figure S35. Get High-res Image Gene #26: 'Amp Peak 26(19q13.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 27(20p13) mutation analysis' versus 'CN_CNMF'

P value = 1.43e-11 (Fisher's exact test), Q value = 1.2e-08

Table S36. Gene #27: 'Amp Peak 27(20p13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 27(20P13) MUTATED	66	97	147
AMP PEAK 27(20P13) WILD-TYPE	100	107	52

Figure S36. Get High-res Image Gene #27: 'Amp Peak 27(20p13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 27(20p13) mutation analysis' versus 'METHLYATION_CNMF'

P value = 8.42e-06 (Fisher's exact test), Q value = 0.0066

Table S37. Gene #27: 'Amp Peak 27(20p13) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 27(20P13) MUTATED	119	82	108
AMP PEAK 27(20P13) WILD-TYPE	52	94	113

Figure S37. Get High-res Image Gene #27: 'Amp Peak 27(20p13) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 28(20q11.21) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 3.68e-08 (Fisher's exact test), Q value = 2.9e-05

Table S38. Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	233	199	125
AMP PEAK 28(20Q11.21) MUTATED	132	143	49
AMP PEAK 28(20Q11.21) WILD-TYPE	101	56	76

Figure S38. Get High-res Image Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 28(20q11.21) mutation analysis' versus 'MIR_CHIERARCHICAL'

P value = 0.000105 (Chi-square test), Q value = 0.08

Table S39. Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3	CLUS_4	CLUS_5	CLUS_6
ALL	65	115	125	99	57	94
AMP PEAK 28(20Q11.21) MUTATED	37	54	71	50	39	73
AMP PEAK 28(20Q11.21) WILD-TYPE	28	61	54	49	18	21

Figure S39. Get High-res Image Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #4: 'MIR_CHIERARCHICAL'

'Amp Peak 28(20q11.21) mutation analysis' versus 'CN_CNMF'

P value = 2.61e-24 (Fisher's exact test), Q value = 2.2e-21

Table S40. Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 28(20Q11.21) MUTATED	69	91	172
AMP PEAK 28(20Q11.21) WILD-TYPE	97	113	27

Figure S40. Get High-res Image Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 28(20q11.21) mutation analysis' versus 'METHLYATION_CNMF'

P value = 6.61e-13 (Fisher's exact test), Q value = 5.4e-10

Table S41. Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 28(20Q11.21) MUTATED	139	88	105
AMP PEAK 28(20Q11.21) WILD-TYPE	32	88	116

Figure S41. Get High-res Image Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 28(20q11.21) mutation analysis' versus 'MRNASEQ_CNMF'

P value = 0.000138 (Fisher's exact test), Q value = 0.1

Table S42. Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	100	67	91
AMP PEAK 28(20Q11.21) MUTATED	60	27	67
AMP PEAK 28(20Q11.21) WILD-TYPE	40	40	24

Figure S42. Get High-res Image Gene #28: 'Amp Peak 28(20q11.21) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

'Amp Peak 29(20q13.33) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 3.75e-05 (Fisher's exact test), Q value = 0.029

Table S43. Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	233	199	125
AMP PEAK 29(20Q13.33) MUTATED	157	158	70
AMP PEAK 29(20Q13.33) WILD-TYPE	76	41	55

Figure S43. Get High-res Image Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Amp Peak 29(20q13.33) mutation analysis' versus 'CN_CNMF'

P value = 6.66e-18 (Fisher's exact test), Q value = 5.5e-15

Table S44. Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 29(20Q13.33) MUTATED	82	131	179
AMP PEAK 29(20Q13.33) WILD-TYPE	84	73	20

Figure S44. Get High-res Image Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 29(20q13.33) mutation analysis' versus 'METHLYATION_CNMF'

P value = 6.08e-08 (Fisher's exact test), Q value = 4.8e-05

Table S45. Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 29(20Q13.33) MUTATED	146	108	138
AMP PEAK 29(20Q13.33) WILD-TYPE	25	68	83

Figure S45. Get High-res Image Gene #29: 'Amp Peak 29(20q13.33) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 31(Xp11.23) mutation analysis' versus 'CN_CNMF'

P value = 7.15e-06 (Fisher's exact test), Q value = 0.0056

Table S46. Gene #31: 'Amp Peak 31(Xp11.23) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 31(XP11.23) MUTATED	29	54	80
AMP PEAK 31(XP11.23) WILD-TYPE	137	150	119

Figure S46. Get High-res Image Gene #31: 'Amp Peak 31(Xp11.23) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Amp Peak 31(Xp11.23) mutation analysis' versus 'METHLYATION_CNMF'

P value = 2.42e-05 (Fisher's exact test), Q value = 0.019

Table S47. Gene #31: 'Amp Peak 31(Xp11.23) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
AMP PEAK 31(XP11.23) MUTATED	72	37	54
AMP PEAK 31(XP11.23) WILD-TYPE	99	139	167

Figure S47. Get High-res Image Gene #31: 'Amp Peak 31(Xp11.23) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Amp Peak 32(Xq28) mutation analysis' versus 'CN_CNMF'

P value = 4.73e-05 (Fisher's exact test), Q value = 0.036

Table S48. Gene #32: 'Amp Peak 32(Xq28) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
AMP PEAK 32(XQ28) MUTATED	44	100	80
AMP PEAK 32(XQ28) WILD-TYPE	122	104	119

Figure S48. Get High-res Image Gene #32: 'Amp Peak 32(Xq28) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 1(1p36.11) mutation analysis' versus 'CN_CNMF'

P value = 1.88e-06 (Fisher's exact test), Q value = 0.0015

Table S49. Gene #33: 'Del Peak 1(1p36.11) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 1(1P36.11) MUTATED	87	114	64
DEL PEAK 1(1P36.11) WILD-TYPE	79	90	135

Figure S49. Get High-res Image Gene #33: 'Del Peak 1(1p36.11) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 2(1q32.3) mutation analysis' versus 'CN_CNMF'

P value = 3.05e-07 (Fisher's exact test), Q value = 0.00024

Table S50. Gene #34: 'Del Peak 2(1q32.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 2(1Q32.3) MUTATED	16	58	21
DEL PEAK 2(1Q32.3) WILD-TYPE	150	146	178

Figure S50. Get High-res Image Gene #34: 'Del Peak 2(1q32.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 5(2q37.3) mutation analysis' versus 'CN_CNMF'

P value = 3.6e-05 (Fisher's exact test), Q value = 0.028

Table S51. Gene #37: 'Del Peak 5(2q37.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 5(2Q37.3) MUTATED	34	85	55
DEL PEAK 5(2Q37.3) WILD-TYPE	132	119	144

Figure S51. Get High-res Image Gene #37: 'Del Peak 5(2q37.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 6(3p26.2) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 6.13e-05 (Fisher's exact test), Q value = 0.047

Table S52. Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	233	199	125
DEL PEAK 6(3P26.2) MUTATED	88	90	27
DEL PEAK 6(3P26.2) WILD-TYPE	145	109	98

Figure S52. Get High-res Image Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 6(3p26.2) mutation analysis' versus 'CN_CNMF'

P value = 6.47e-05 (Fisher's exact test), Q value = 0.049

Table S53. Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 6(3P26.2) MUTATED	44	70	96
DEL PEAK 6(3P26.2) WILD-TYPE	122	134	103

Figure S53. Get High-res Image Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 6(3p26.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000102 (Fisher's exact test), Q value = 0.078

Table S54. Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 6(3P26.2) MUTATED	85	50	74
DEL PEAK 6(3P26.2) WILD-TYPE	86	126	147

Figure S54. Get High-res Image Gene #38: 'Del Peak 6(3p26.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 9(5q11.2) mutation analysis' versus 'CN_CNMF'

P value = 4.69e-08 (Fisher's exact test), Q value = 3.7e-05

Table S55. Gene #41: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 9(5Q11.2) MUTATED	69	143	129
DEL PEAK 9(5Q11.2) WILD-TYPE	97	61	70

Figure S55. Get High-res Image Gene #41: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 9(5q11.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.00021 (Fisher's exact test), Q value = 0.16

Table S56. Gene #41: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 9(5Q11.2) MUTATED	113	83	144
DEL PEAK 9(5Q11.2) WILD-TYPE	58	93	77

Figure S56. Get High-res Image Gene #41: 'Del Peak 9(5q11.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 10(5q13.2) mutation analysis' versus 'CN_CNMF'

P value = 2.07e-12 (Fisher's exact test), Q value = 1.7e-09

Table S57. Gene #42: 'Del Peak 10(5q13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 10(5Q13.2) MUTATED	87	177	142
DEL PEAK 10(5Q13.2) WILD-TYPE	79	27	57

Figure S57. Get High-res Image Gene #42: 'Del Peak 10(5q13.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 11(6q27) mutation analysis' versus 'CN_CNMF'

P value = 3.86e-09 (Fisher's exact test), Q value = 3.1e-06

Table S58. Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 11(6Q27) MUTATED	122	159	100
DEL PEAK 11(6Q27) WILD-TYPE	44	45	99

Figure S58. Get High-res Image Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 11(6q27) mutation analysis' versus 'METHLYATION_CNMF'

P value = 1.84e-05 (Fisher's exact test), Q value = 0.014

Table S59. Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 11(6Q27) MUTATED	91	134	155
DEL PEAK 11(6Q27) WILD-TYPE	80	42	66

Figure S59. Get High-res Image Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 11(6q27) mutation analysis' versus 'MRNASEQ_CNMF'

P value = 2.69e-05 (Fisher's exact test), Q value = 0.021

Table S60. Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	100	67	91
DEL PEAK 11(6Q27) MUTATED	68	51	39
DEL PEAK 11(6Q27) WILD-TYPE	32	16	52

Figure S60. Get High-res Image Gene #43: 'Del Peak 11(6q27) mutation analysis' versus Clinical Feature #9: 'MRNASEQ_CNMF'

'Del Peak 12(7p22.1) mutation analysis' versus 'CN_CNMF'

P value = 2.78e-13 (Fisher's exact test), Q value = 2.3e-10

Table S61. Gene #44: 'Del Peak 12(7p22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 12(7P22.1) MUTATED	47	131	69
DEL PEAK 12(7P22.1) WILD-TYPE	119	73	130

Figure S61. Get High-res Image Gene #44: 'Del Peak 12(7p22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 13(8p23.3) mutation analysis' versus 'CN_CNMF'

P value = 1.1e-11 (Fisher's exact test), Q value = 9e-09

Table S62. Gene #45: 'Del Peak 13(8p23.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 13(8P23.3) MUTATED	75	161	145
DEL PEAK 13(8P23.3) WILD-TYPE	91	43	54

Figure S62. Get High-res Image Gene #45: 'Del Peak 13(8p23.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 14(8p21.2) mutation analysis' versus 'CN_CNMF'

P value = 1.1e-08 (Fisher's exact test), Q value = 8.8e-06

Table S63. Gene #46: 'Del Peak 14(8p21.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 14(8P21.2) MUTATED	86	163	149
DEL PEAK 14(8P21.2) WILD-TYPE	80	41	50

Figure S63. Get High-res Image Gene #46: 'Del Peak 14(8p21.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 15(9p24.3) mutation analysis' versus 'MRNA_CNMF'

P value = 0.000117 (Fisher's exact test), Q value = 0.089

Table S64. Gene #47: 'Del Peak 15(9p24.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	215	213	129
DEL PEAK 15(9P24.3) MUTATED	110	70	66
DEL PEAK 15(9P24.3) WILD-TYPE	105	143	63

Figure S64. Get High-res Image Gene #47: 'Del Peak 15(9p24.3) mutation analysis' versus Clinical Feature #1: 'MRNA_CNMF'

'Del Peak 15(9p24.3) mutation analysis' versus 'METHLYATION_CNMF'

P value = 0.000244 (Fisher's exact test), Q value = 0.18

Table S65. Gene #47: 'Del Peak 15(9p24.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 15(9P24.3) MUTATED	91	88	76
DEL PEAK 15(9P24.3) WILD-TYPE	80	88	145

Figure S65. Get High-res Image Gene #47: 'Del Peak 15(9p24.3) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 16(9q34.13) mutation analysis' versus 'CN_CNMF'

P value = 2.94e-07 (Fisher's exact test), Q value = 0.00023

Table S66. Gene #48: 'Del Peak 16(9q34.13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 16(9Q34.13) MUTATED	87	102	148
DEL PEAK 16(9Q34.13) WILD-TYPE	79	102	51

Figure S66. Get High-res Image Gene #48: 'Del Peak 16(9q34.13) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 18(10q23.31) mutation analysis' versus 'CN_CNMF'

P value = 0.000247 (Fisher's exact test), Q value = 0.19

Table S67. Gene #50: 'Del Peak 18(10q23.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 18(10Q23.31) MUTATED	43	91	86
DEL PEAK 18(10Q23.31) WILD-TYPE	123	113	113

Figure S67. Get High-res Image Gene #50: 'Del Peak 18(10q23.31) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 19(10q26.3) mutation analysis' versus 'CN_CNMF'

P value = 1.08e-05 (Fisher's exact test), Q value = 0.0084

Table S68. Gene #51: 'Del Peak 19(10q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 19(10Q26.3) MUTATED	32	85	72
DEL PEAK 19(10Q26.3) WILD-TYPE	134	119	127

Figure S68. Get High-res Image Gene #51: 'Del Peak 19(10q26.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 20(11p15.5) mutation analysis' versus 'CN_CNMF'

P value = 6.76e-12 (Fisher's exact test), Q value = 5.5e-09

Table S69. Gene #52: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 20(11P15.5) MUTATED	75	160	103
DEL PEAK 20(11P15.5) WILD-TYPE	91	44	96

Figure S69. Get High-res Image Gene #52: 'Del Peak 20(11p15.5) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 22(12q24.33) mutation analysis' versus 'MRNA_CHIERARCHICAL'

P value = 2.63e-06 (Fisher's exact test), Q value = 0.0021

Table S70. Gene #54: 'Del Peak 22(12q24.33) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	233	199	125
DEL PEAK 22(12Q24.33) MUTATED	101	49	62
DEL PEAK 22(12Q24.33) WILD-TYPE	132	150	63

Figure S70. Get High-res Image Gene #54: 'Del Peak 22(12q24.33) mutation analysis' versus Clinical Feature #2: 'MRNA_CHIERARCHICAL'

'Del Peak 22(12q24.33) mutation analysis' versus 'CN_CNMF'

P value = 4.83e-10 (Fisher's exact test), Q value = 3.9e-07

Table S71. Gene #54: 'Del Peak 22(12q24.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 22(12Q24.33) MUTATED	55	113	49
DEL PEAK 22(12Q24.33) WILD-TYPE	111	91	150

Figure S71. Get High-res Image Gene #54: 'Del Peak 22(12q24.33) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 23(13q14.2) mutation analysis' versus 'CN_CNMF'

P value = 1.29e-06 (Fisher's exact test), Q value = 0.001

Table S72. Gene #55: 'Del Peak 23(13q14.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 23(13Q14.2) MUTATED	83	154	118
DEL PEAK 23(13Q14.2) WILD-TYPE	83	50	81

Figure S72. Get High-res Image Gene #55: 'Del Peak 23(13q14.2) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 23(13q14.2) mutation analysis' versus 'METHLYATION_CNMF'

P value = 9.52e-06 (Fisher's exact test), Q value = 0.0074

Table S73. Gene #55: 'Del Peak 23(13q14.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 23(13Q14.2) MUTATED	109	86	160
DEL PEAK 23(13Q14.2) WILD-TYPE	62	90	61

Figure S73. Get High-res Image Gene #55: 'Del Peak 23(13q14.2) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 24(14q23.3) mutation analysis' versus 'CN_CNMF'

P value = 0.000143 (Fisher's exact test), Q value = 0.11

Table S74. Gene #56: 'Del Peak 24(14q23.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 24(14Q23.3) MUTATED	69	103	126
DEL PEAK 24(14Q23.3) WILD-TYPE	97	101	73

Figure S74. Get High-res Image Gene #56: 'Del Peak 24(14q23.3) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 25(15q15.1) mutation analysis' versus 'CN_CNMF'

P value = 2.28e-11 (Fisher's exact test), Q value = 1.9e-08

Table S75. Gene #57: 'Del Peak 25(15q15.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 25(15Q15.1) MUTATED	79	117	161
DEL PEAK 25(15Q15.1) WILD-TYPE	87	87	38

Figure S75. Get High-res Image Gene #57: 'Del Peak 25(15q15.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 25(15q15.1) mutation analysis' versus 'METHLYATION_CNMF'

P value = 6.14e-05 (Fisher's exact test), Q value = 0.047

Table S76. Gene #57: 'Del Peak 25(15q15.1) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 25(15Q15.1) MUTATED	130	97	130
DEL PEAK 25(15Q15.1) WILD-TYPE	41	79	91

Figure S76. Get High-res Image Gene #57: 'Del Peak 25(15q15.1) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

'Del Peak 27(16q22.1) mutation analysis' versus 'CN_CNMF'

P value = 0.000316 (Fisher's exact test), Q value = 0.24

Table S77. Gene #59: 'Del Peak 27(16q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 27(16Q22.1) MUTATED	114	167	170
DEL PEAK 27(16Q22.1) WILD-TYPE	52	37	29

Figure S77. Get High-res Image Gene #59: 'Del Peak 27(16q22.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 28(16q23.1) mutation analysis' versus 'CN_CNMF'

P value = 5.1e-05 (Fisher's exact test), Q value = 0.039

Table S78. Gene #60: 'Del Peak 28(16q23.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	166	204	199
DEL PEAK 28(16Q23.1) MUTATED	109	164	169
DEL PEAK 28(16Q23.1) WILD-TYPE	57	40	30

Figure S78. Get High-res Image Gene #60: 'Del Peak 28(16q23.1) mutation analysis' versus Clinical Feature #5: 'CN_CNMF'

'Del Peak 34(19q13.43) mutation analysis' versus 'METHLYATION_CNMF'

P value = 6.49e-05 (Fisher's exact test), Q value = 0.049

Table S79. Gene #66: 'Del Peak 34(19q13.43) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

nPatients	CLUS_1	CLUS_2	CLUS_3
ALL	171	176	221
DEL PEAK 34(19Q13.43) MUTATED	103	65	112
DEL PEAK 34(19Q13.43) WILD-TYPE	68	111	109

Figure S79. Get High-res Image Gene #66: 'Del Peak 34(19q13.43) mutation analysis' versus Clinical Feature #6: 'METHLYATION_CNMF'

Methods & Data

Input

Copy number data file = All Lesions File (all_lesions.conf_##.txt, where ## is the confidence level). The all lesions file is from GISTIC pipeline and summarizes the results from the GISTIC run. It contains data about the significant regions of amplification and deletion as well as which samples are amplified or deleted in each of these regions. The identified regions are listed down the first column, and the samples are listed across the first row, starting in column 10.
Molecular subtype file = OV-TP.transferedmergedcluster.txt
Number of patients = 569
Number of copy number variation regions = 69
Number of molecular subtypes = 12
Exclude regions that fewer than K tumors have alterations, K = 3

Fisher's exact test

For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R

Chi-square test

For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R

Q value calculation

For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.

Download Results

This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.

References

[1] Fisher, R.A., On the interpretation of chi-square from contingency tables, and the calculation of P, Journal of the Royal Statistical Society 85(1):87-94 (1922)

[2] Greenwood and Nikulin, A guide to chi-squared testing, Wiley, New York. ISBN 047155779X (1996)

[3] Benjamini and Hochberg, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society Series B 59:289-300 (1995)

[4] GISTIC_version2

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