Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	49.0	393.0	8.0	-0.12	0.065	1000.0	-1000.0	-0.013	-1000.0
TCGA08_p53	46.0	327.0	7.0	-0.095	0.058	1000.0	-1000.0	-0.01	-1000.0
Syndecan-1-mediated signaling events	36.0	1253.0	34.0	-0.204	0.012	1000.0	-1000.0	-0.046	-1000.0
IL4-mediated signaling events	35.0	3275.0	91.0	-0.725	0.586	1000.0	-1000.0	-0.159	-1000.0
FOXA2 and FOXA3 transcription factor networks	35.0	1643.0	46.0	-0.53	0.011	1000.0	-1000.0	-0.088	-1000.0
IL23-mediated signaling events	34.0	2097.0	60.0	-0.484	0.012	1000.0	-1000.0	-0.177	-1000.0
TCR signaling in naïve CD8+ T cells	33.0	3093.0	93.0	-0.201	0.028	1000.0	-1000.0	-0.078	-1000.0
Signaling events regulated by Ret tyrosine kinase	29.0	2413.0	82.0	-0.183	0.012	1000.0	-1000.0	-0.083	-1000.0
Wnt signaling	29.0	209.0	7.0	-0.141	0.009	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by the Hedgehog family	27.0	1404.0	52.0	-0.258	0.096	1000.0	-1000.0	-0.043	-1000.0
IL12-mediated signaling events	25.0	2249.0	87.0	-0.288	0.055	1000.0	-1000.0	-0.131	-1000.0
Noncanonical Wnt signaling pathway	23.0	609.0	26.0	-0.141	0.012	1000.0	-1000.0	-0.056	-1000.0
amb2 Integrin signaling	23.0	1910.0	82.0	-0.232	0.015	1000.0	-1000.0	-0.079	-1000.0
Ephrin B reverse signaling	23.0	1110.0	48.0	-0.156	0.016	1000.0	-1000.0	-0.066	-1000.0
BCR signaling pathway	22.0	2219.0	99.0	-0.202	0.017	1000.0	-1000.0	-0.083	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	21.0	714.0	34.0	-0.116	0.012	1000.0	-1000.0	-0.037	-1000.0
Glypican 1 network	21.0	1048.0	48.0	-0.194	0.022	1000.0	-1000.0	-0.047	-1000.0
Reelin signaling pathway	21.0	1188.0	56.0	-0.222	0.029	1000.0	-1000.0	-0.078	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1100.0	52.0	-0.25	0.039	1000.0	-1000.0	-0.047	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	21.0	1471.0	68.0	-0.281	0.109	1000.0	-1000.0	-0.127	-1000.0
Visual signal transduction: Rods	21.0	1117.0	52.0	-0.162	0.012	1000.0	-1000.0	-0.068	-1000.0
LPA4-mediated signaling events	20.0	246.0	12.0	-0.129	0.016	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	20.0	1541.0	74.0	-0.168	0.061	1000.0	-1000.0	-0.048	-1000.0
p75(NTR)-mediated signaling	20.0	2509.0	125.0	-0.229	0.034	1000.0	-1000.0	-0.097	-1000.0
Endothelins	20.0	1988.0	96.0	-0.161	0.012	1000.0	-1000.0	-0.081	-1000.0
Glypican 2 network	20.0	80.0	4.0	-0.046	-0.043	1000.0	-1000.0	-0.024	-1000.0
Signaling mediated by p38-alpha and p38-beta	19.0	855.0	44.0	-0.113	0.012	1000.0	-1000.0	-0.041	-1000.0
Effects of Botulinum toxin	19.0	504.0	26.0	-0.174	0.014	1000.0	-1000.0	-0.054	-1000.0
Syndecan-4-mediated signaling events	19.0	1327.0	67.0	-0.151	0.016	1000.0	-1000.0	-0.08	-1000.0
Visual signal transduction: Cones	18.0	703.0	38.0	-0.107	0.012	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	18.0	1900.0	105.0	-0.115	0.029	1000.0	-1000.0	-0.055	-1000.0
BMP receptor signaling	18.0	1535.0	81.0	-0.221	0.036	1000.0	-1000.0	-0.089	-1000.0
Class IB PI3K non-lipid kinase events	18.0	54.0	3.0	-0.021	-1000.0	1000.0	-1000.0	-0.008	-1000.0
ErbB2/ErbB3 signaling events	17.0	1109.0	65.0	-0.16	0.017	1000.0	-1000.0	-0.064	-1000.0
Glucocorticoid receptor regulatory network	17.0	1962.0	114.0	-0.426	0.245	1000.0	-1000.0	-0.069	-1000.0
HIF-1-alpha transcription factor network	16.0	1224.0	76.0	-0.255	0.037	1000.0	-1000.0	-0.177	-1000.0
ErbB4 signaling events	15.0	1092.0	69.0	-0.195	0.132	1000.0	-1000.0	-0.088	-1000.0
Fc-epsilon receptor I signaling in mast cells	15.0	1521.0	97.0	-0.133	0.027	1000.0	-1000.0	-0.068	-1000.0
EGFR-dependent Endothelin signaling events	15.0	315.0	21.0	-0.082	0.017	1000.0	-1000.0	-0.064	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1910.0	120.0	-0.232	0.074	1000.0	-1000.0	-0.066	-1000.0
Ephrin A  reverse signaling	14.0	103.0	7.0	-0.02	-0.0	1000.0	-1000.0	-0.024	-1000.0
JNK signaling in the CD4+ TCR pathway	14.0	242.0	17.0	-0.068	0.012	1000.0	-1000.0	-0.034	-1000.0
Nongenotropic Androgen signaling	14.0	759.0	52.0	-0.098	0.014	1000.0	-1000.0	-0.054	-1000.0
Retinoic acid receptors-mediated signaling	13.0	809.0	58.0	-0.224	0.024	1000.0	-1000.0	-0.07	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	429.0	31.0	-0.128	0.012	1000.0	-1000.0	-0.076	-1000.0
Osteopontin-mediated events	12.0	475.0	38.0	-0.091	0.014	1000.0	-1000.0	-0.095	-1000.0
PDGFR-alpha signaling pathway	12.0	564.0	44.0	-0.081	0.02	1000.0	-1000.0	-0.059	-1000.0
IL27-mediated signaling events	12.0	656.0	51.0	-0.118	0.046	1000.0	-1000.0	-0.079	-1000.0
Coregulation of Androgen receptor activity	11.0	849.0	76.0	-0.19	0.024	1000.0	-1000.0	-0.04	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	627.0	54.0	-0.181	0.023	1000.0	-1000.0	-0.091	-1000.0
Arf6 signaling events	11.0	709.0	62.0	-0.094	0.027	1000.0	-1000.0	-0.053	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	1011.0	85.0	-0.075	0.019	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PTP1B	11.0	892.0	76.0	-0.101	0.034	1000.0	-1000.0	-0.076	-1000.0
Syndecan-3-mediated signaling events	11.0	409.0	35.0	-0.147	0.034	1000.0	-1000.0	-0.052	-1000.0
Integrins in angiogenesis	11.0	937.0	84.0	-0.094	0.02	1000.0	-1000.0	-0.077	-1000.0
LPA receptor mediated events	11.0	1208.0	102.0	-0.1	0.03	1000.0	-1000.0	-0.082	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	11.0	897.0	78.0	-0.068	0.051	1000.0	-1000.0	-0.085	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1375.0	136.0	-0.303	0.121	1000.0	-1000.0	-0.068	-1000.0
BARD1 signaling events	10.0	575.0	57.0	-0.053	0.043	1000.0	-1000.0	-0.056	-1000.0
FAS signaling pathway (CD95)	10.0	513.0	47.0	-0.128	0.013	1000.0	-1000.0	-0.041	-1000.0
EPHB forward signaling	10.0	898.0	85.0	-0.072	0.064	1000.0	-1000.0	-0.082	-1000.0
IL6-mediated signaling events	10.0	751.0	75.0	-0.12	0.042	1000.0	-1000.0	-0.075	-1000.0
Angiopoietin receptor Tie2-mediated signaling	10.0	890.0	88.0	-0.115	0.023	1000.0	-1000.0	-0.101	-1000.0
Ras signaling in the CD4+ TCR pathway	10.0	174.0	17.0	-0.041	0.014	1000.0	-1000.0	-0.035	-1000.0
Nectin adhesion pathway	9.0	578.0	63.0	-0.054	0.019	1000.0	-1000.0	-0.066	-1000.0
TRAIL signaling pathway	9.0	446.0	48.0	-0.038	0.024	1000.0	-1000.0	-0.068	-1000.0
IL1-mediated signaling events	9.0	614.0	62.0	-0.082	0.05	1000.0	-1000.0	-0.083	-1000.0
Plasma membrane estrogen receptor signaling	9.0	805.0	86.0	-0.098	0.021	1000.0	-1000.0	-0.085	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	9.0	321.0	33.0	-0.13	0.033	1000.0	-1000.0	-0.037	-1000.0
Regulation of Androgen receptor activity	9.0	655.0	70.0	-0.249	0.024	1000.0	-1000.0	-0.076	-1000.0
Cellular roles of Anthrax toxin	8.0	328.0	39.0	-0.084	0.013	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	8.0	348.0	40.0	-0.163	0.069	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	8.0	144.0	17.0	-0.098	0.021	1000.0	-1000.0	-0.039	-1000.0
S1P1 pathway	8.0	288.0	36.0	-0.098	0.012	1000.0	-1000.0	-0.053	-1000.0
IL2 signaling events mediated by PI3K	8.0	480.0	58.0	-0.062	0.028	1000.0	-1000.0	-0.083	-1000.0
Canonical Wnt signaling pathway	8.0	450.0	51.0	-0.14	0.05	1000.0	-1000.0	-0.07	-1000.0
IL2 signaling events mediated by STAT5	8.0	192.0	22.0	-0.061	0.012	1000.0	-1000.0	-0.066	-1000.0
FOXM1 transcription factor network	8.0	420.0	51.0	-0.131	0.113	1000.0	-1000.0	-0.196	-1000.0
Syndecan-2-mediated signaling events	7.0	542.0	69.0	-0.087	0.03	1000.0	-1000.0	-0.038	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	473.0	61.0	-0.128	0.034	1000.0	-1000.0	-0.078	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	345.0	45.0	-0.096	0.026	1000.0	-1000.0	-0.086	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	180.0	28.0	-0.098	0.019	1000.0	-1000.0	-0.036	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	30.0	5.0	-0.005	0.006	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	6.0	45.0	7.0	-0.041	0.004	1000.0	-1000.0	-0.024	-1000.0
Ceramide signaling pathway	6.0	458.0	76.0	-0.077	0.032	1000.0	-1000.0	-0.047	-1000.0
TCGA08_rtk_signaling	6.0	176.0	26.0	-0.045	0.031	1000.0	-1000.0	-0.021	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	473.0	74.0	-0.076	0.06	1000.0	-1000.0	-0.077	-1000.0
Class I PI3K signaling events	6.0	507.0	73.0	-0.076	0.027	1000.0	-1000.0	-0.056	-1000.0
Regulation of Telomerase	6.0	629.0	102.0	-0.147	0.033	1000.0	-1000.0	-0.1	-1000.0
IGF1 pathway	6.0	384.0	57.0	-0.026	0.024	1000.0	-1000.0	-0.09	-1000.0
S1P3 pathway	6.0	256.0	42.0	-0.098	0.017	1000.0	-1000.0	-0.041	-1000.0
S1P4 pathway	6.0	173.0	25.0	-0.098	0.019	1000.0	-1000.0	-0.037	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	360.0	65.0	-0.235	0.039	1000.0	-1000.0	-0.068	-1000.0
Aurora A signaling	5.0	346.0	60.0	-0.112	0.028	1000.0	-1000.0	-0.038	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	216.0	37.0	-0.048	0.021	1000.0	-1000.0	-0.042	-1000.0
HIF-2-alpha transcription factor network	5.0	225.0	43.0	-0.071	0.072	1000.0	-1000.0	-0.067	-1000.0
Regulation of p38-alpha and p38-beta	5.0	307.0	54.0	-0.106	0.03	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by PRL	5.0	176.0	34.0	-0.099	0.021	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	4.0	266.0	55.0	-0.019	0.047	1000.0	-1000.0	-0.08	-1000.0
IFN-gamma pathway	4.0	272.0	68.0	-0.094	0.039	1000.0	-1000.0	-0.094	-1000.0
ceramide signaling pathway	4.0	218.0	49.0	-0.077	0.021	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	4.0	86.0	20.0	-0.027	0.013	1000.0	-1000.0	-0.019	-1000.0
Aurora B signaling	4.0	307.0	67.0	-0.089	0.02	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class II	3.0	227.0	75.0	-0.046	0.034	1000.0	-1000.0	-0.04	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	329.0	83.0	-0.169	0.044	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class I	3.0	342.0	104.0	-0.077	0.045	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.03	0.024	1000.0	-1000.0	-0.036	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	137.0	36.0	-0.048	0.026	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	281.0	76.0	-0.045	0.038	1000.0	-1000.0	-0.073	-1000.0
Insulin Pathway	3.0	237.0	74.0	-0.115	0.03	1000.0	-1000.0	-0.084	-1000.0
E-cadherin signaling events	3.0	15.0	5.0	-0.001	0.015	1000.0	-1000.0	-0.02	-1000.0
p38 MAPK signaling pathway	3.0	156.0	44.0	-0.094	0.024	1000.0	-1000.0	-0.062	-1000.0
Canonical NF-kappaB pathway	2.0	111.0	39.0	-0.077	0.06	1000.0	-1000.0	-0.076	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	0.002	0.012	1000.0	-1000.0	-0.017	-1000.0
Arf6 downstream pathway	2.0	90.0	43.0	-0.02	0.021	1000.0	-1000.0	-0.039	-1000.0
PLK1 signaling events	2.0	186.0	85.0	-0.014	0.028	1000.0	-1000.0	-0.035	-1000.0
FoxO family signaling	2.0	189.0	64.0	-0.113	0.086	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	263.0	125.0	-0.054	0.067	1000.0	-1000.0	-0.091	-1000.0
PDGFR-beta signaling pathway	2.0	290.0	97.0	-0.046	0.042	1000.0	-1000.0	-0.075	-1000.0
E-cadherin signaling in keratinocytes	2.0	118.0	43.0	-0.04	0.033	1000.0	-1000.0	-0.057	-1000.0
Circadian rhythm pathway	1.0	43.0	22.0	-0.026	0.031	1000.0	-1000.0	-0.045	-1000.0
Insulin-mediated glucose transport	1.0	58.0	32.0	-0.04	0.024	1000.0	-1000.0	-0.053	-1000.0
mTOR signaling pathway	1.0	71.0	53.0	-0.004	0.028	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	84.0	68.0	-0.04	0.042	1000.0	-1000.0	-0.05	-1000.0
Atypical NF-kappaB pathway	1.0	60.0	31.0	-0.03	0.028	1000.0	-1000.0	-0.039	-1000.0
Arf6 trafficking events	1.0	117.0	71.0	-0.058	0.037	1000.0	-1000.0	-0.065	-1000.0
VEGFR1 specific signals	1.0	99.0	56.0	-0.01	0.044	1000.0	-1000.0	-0.054	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	0.006	0.036	1000.0	-1000.0	-0.05	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	0.0	0.028	1000.0	-1000.0	-0.046	-1000.0
Arf1 pathway	0.0	12.0	54.0	-0.0	0.026	1000.0	-1000.0	-0.032	-1000.0
Alternative NF-kappaB pathway	0.0	7.0	13.0	-0.0	0.033	1000.0	-1000.0	-0.038	-1000.0
Total	1512	87085	7203	-15.7559476554	-995.117785792	131000	-131000	-8.21705466132	-131000