Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.05 0.021 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.0 0.087 0.395 4.0 -9999.0 0.0 4.0 EGFR 0.008 0.088 -9999.0 0.0 -0.456 6.0 6.0 EPHA2 -0.02 0.141 -9999.0 0.0 -0.431 18.0 18.0 MYO6 0.001 0.071 0.227 9.0 -9999.0 0.0 9.0 CTNNB1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.051 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.207 0.224 -9999.0 0.0 -0.43 87.0 87.0 CTNND1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.026 0.054 0.212 12.0 -9999.0 0.0 12.0 regulation of calcium-dependent cell-cell adhesion 0.016 0.062 0.2 10.0 -0.227 5.0 15.0 EGF -0.023 0.111 -9999.0 0.0 -0.254 31.0 31.0 NCKAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.007 0.087 0.361 1.0 -0.452 5.0 6.0 cortical microtubule organization 0.05 0.021 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.007 0.056 0.202 12.0 -9999.0 0.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.055 0.023 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.026 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.034 0.083 -9999.0 0.0 -0.253 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.01 0.028 0.191 1.0 -9999.0 0.0 1.0 PVRL2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.018 0.033 0.179 7.0 -9999.0 0.0 7.0 ARF6/GTP 0.04 0.081 -9999.0 0.0 -0.237 11.0 11.0 CDH1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.011 0.073 -9999.0 0.0 -0.231 7.0 7.0 RhoA/GDP 0.051 0.022 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.012 0.057 0.196 7.0 -9999.0 0.0 7.0 IGF-1R heterotetramer 0.023 0.028 -9999.0 0.0 -0.232 2.0 2.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.028 -9999.0 0.0 -0.232 2.0 2.0 IGF1 -0.014 0.124 -9999.0 0.0 -0.377 17.0 17.0 DIAPH1 0.029 0.101 -9999.0 0.0 -0.565 1.0 1.0 Wnt receptor signaling pathway -0.05 0.021 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.026 0.049 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.012 0.058 0.198 7.0 -9999.0 0.0 7.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.002 0.055 0.226 8.0 -0.225 1.0 9.0 Ephrin A1/EPHA2 0.021 0.076 -9999.0 0.0 -0.22 14.0 14.0 SEC6/SEC8 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.016 0.063 0.202 10.0 -0.23 5.0 15.0 HGF/MET 0.015 0.08 -9999.0 0.0 -0.238 12.0 12.0 HGF 0.004 0.078 -9999.0 0.0 -0.269 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.038 0.105 0.299 16.0 -0.262 1.0 17.0 KIAA1543 0.005 0.05 0.19 11.0 -9999.0 0.0 11.0 KIFC3 0.014 0.041 0.179 6.0 -0.23 2.0 8.0 NCK1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.025 0.053 0.216 11.0 -9999.0 0.0 11.0 NCK1/GIT1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.05 0.021 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.025 0.053 0.217 11.0 -9999.0 0.0 11.0 PIP5K1C 0.026 0.054 0.213 12.0 -9999.0 0.0 12.0 LIMA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.007 0.104 0.403 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.001 0.103 0.305 4.0 -0.485 4.0 8.0 IGF-1R heterotetramer/IGF1 0.022 0.07 -9999.0 0.0 -0.22 11.0 11.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.006 0.117 -9999.0 0.0 -0.456 11.0 11.0 PLEKHA7 0.024 0.047 0.199 11.0 -9999.0 0.0 11.0 mol:GTP 0.032 0.082 -9999.0 0.0 -0.252 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.019 0.095 0.384 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.012 0.057 0.196 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0