Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	69.0	3590.0	52.0	-0.259	0.109	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-alpha and p38-beta	52.0	2302.0	44.0	-0.187	0.012	1000.0	-1000.0	-0.032	-1000.0
TCGA08_retinoblastoma	52.0	421.0	8.0	-0.105	0.051	1000.0	-1000.0	-0.013	-1000.0
Ephrin A  reverse signaling	51.0	360.0	7.0	-0.077	-0.0	1000.0	-1000.0	-0.017	-1000.0
IL23-mediated signaling events	51.0	3080.0	60.0	-0.506	0.012	1000.0	-1000.0	-0.17	-1000.0
FOXA2 and FOXA3 transcription factor networks	48.0	2213.0	46.0	-0.434	0.014	1000.0	-1000.0	-0.116	-1000.0
Wnt signaling	48.0	339.0	7.0	-0.131	-0.014	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	46.0	4267.0	91.0	-0.703	0.55	1000.0	-1000.0	-0.161	-1000.0
Syndecan-1-mediated signaling events	43.0	1491.0	34.0	-0.169	0.012	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	41.0	1991.0	48.0	-0.135	0.023	1000.0	-1000.0	-0.033	-1000.0
BMP receptor signaling	40.0	3309.0	81.0	-0.213	0.04	1000.0	-1000.0	-0.079	-1000.0
HIF-1-alpha transcription factor network	38.0	2891.0	76.0	-0.318	0.019	1000.0	-1000.0	-0.136	-1000.0
TCR signaling in naïve CD8+ T cells	38.0	3569.0	93.0	-0.134	0.077	1000.0	-1000.0	-0.07	-1000.0
p75(NTR)-mediated signaling	37.0	4644.0	125.0	-0.246	0.032	1000.0	-1000.0	-0.083	-1000.0
Class IB PI3K non-lipid kinase events	37.0	111.0	3.0	-0.038	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Glypican 2 network	35.0	140.0	4.0	-0.039	-0.03	1000.0	-1000.0	-0.019	-1000.0
Noncanonical Wnt signaling pathway	33.0	859.0	26.0	-0.131	0.012	1000.0	-1000.0	-0.045	-1000.0
EPHB forward signaling	33.0	2836.0	85.0	-0.134	0.105	1000.0	-1000.0	-0.078	-1000.0
TCGA08_p53	32.0	227.0	7.0	-0.077	0.046	1000.0	-1000.0	-0.007	-1000.0
Signaling events regulated by Ret tyrosine kinase	31.0	2551.0	82.0	-0.155	0.012	1000.0	-1000.0	-0.077	-1000.0
Syndecan-4-mediated signaling events	31.0	2128.0	67.0	-0.165	0.016	1000.0	-1000.0	-0.057	-1000.0
IL12-mediated signaling events	30.0	2615.0	87.0	-0.23	0.04	1000.0	-1000.0	-0.132	-1000.0
amb2 Integrin signaling	29.0	2429.0	82.0	-0.25	0.017	1000.0	-1000.0	-0.069	-1000.0
Reelin signaling pathway	29.0	1679.0	56.0	-0.144	0.03	1000.0	-1000.0	-0.063	-1000.0
Ephrin B reverse signaling	29.0	1392.0	48.0	-0.102	0.061	1000.0	-1000.0	-0.054	-1000.0
Endothelins	29.0	2810.0	96.0	-0.236	0.028	1000.0	-1000.0	-0.077	-1000.0
Glucocorticoid receptor regulatory network	28.0	3282.0	114.0	-0.467	0.247	1000.0	-1000.0	-0.072	-1000.0
LPA receptor mediated events	27.0	2781.0	102.0	-0.125	0.014	1000.0	-1000.0	-0.073	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	27.0	1857.0	68.0	-0.253	0.087	1000.0	-1000.0	-0.119	-1000.0
BCR signaling pathway	26.0	2632.0	99.0	-0.154	0.018	1000.0	-1000.0	-0.08	-1000.0
Canonical Wnt signaling pathway	25.0	1312.0	51.0	-0.251	0.105	1000.0	-1000.0	-0.063	-1000.0
IGF1 pathway	25.0	1428.0	57.0	-0.075	0.025	1000.0	-1000.0	-0.082	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	25.0	3022.0	120.0	-0.154	0.119	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Rods	25.0	1304.0	52.0	-0.14	0.012	1000.0	-1000.0	-0.065	-1000.0
Thromboxane A2 receptor signaling	24.0	2563.0	105.0	-0.11	0.032	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	24.0	2088.0	86.0	-0.092	0.077	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	24.0	1924.0	78.0	-0.12	0.06	1000.0	-1000.0	-0.075	-1000.0
Caspase cascade in apoptosis	23.0	1721.0	74.0	-0.102	0.029	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	23.0	1619.0	69.0	-0.135	0.023	1000.0	-1000.0	-0.029	-1000.0
PDGFR-alpha signaling pathway	23.0	1035.0	44.0	-0.056	0.019	1000.0	-1000.0	-0.055	-1000.0
Nectin adhesion pathway	23.0	1482.0	63.0	-0.068	0.027	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	23.0	605.0	26.0	-0.108	0.012	1000.0	-1000.0	-0.052	-1000.0
Angiopoietin receptor Tie2-mediated signaling	23.0	2055.0	88.0	-0.121	0.016	1000.0	-1000.0	-0.094	-1000.0
Integrins in angiogenesis	22.0	1899.0	84.0	-0.128	0.021	1000.0	-1000.0	-0.075	-1000.0
LPA4-mediated signaling events	21.0	258.0	12.0	-0.042	0.015	1000.0	-1000.0	-0.028	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	20.0	707.0	34.0	-0.047	0.012	1000.0	-1000.0	-0.04	-1000.0
Presenilin action in Notch and Wnt signaling	20.0	1279.0	61.0	-0.251	0.038	1000.0	-1000.0	-0.069	-1000.0
Retinoic acid receptors-mediated signaling	19.0	1143.0	58.0	-0.142	0.024	1000.0	-1000.0	-0.07	-1000.0
Nongenotropic Androgen signaling	19.0	995.0	52.0	-0.068	0.012	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by PTP1B	18.0	1412.0	76.0	-0.141	0.018	1000.0	-1000.0	-0.068	-1000.0
Coregulation of Androgen receptor activity	17.0	1308.0	76.0	-0.106	0.029	1000.0	-1000.0	-0.031	-1000.0
Arf6 signaling events	17.0	1077.0	62.0	-0.075	0.016	1000.0	-1000.0	-0.042	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	17.0	1466.0	85.0	-0.051	0.012	1000.0	-1000.0	-0.061	-1000.0
IL1-mediated signaling events	17.0	1088.0	62.0	-0.076	0.031	1000.0	-1000.0	-0.079	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	17.0	900.0	52.0	-0.116	0.023	1000.0	-1000.0	-0.045	-1000.0
FAS signaling pathway (CD95)	17.0	812.0	47.0	-0.071	0.024	1000.0	-1000.0	-0.046	-1000.0
IL6-mediated signaling events	17.0	1321.0	75.0	-0.172	0.036	1000.0	-1000.0	-0.069	-1000.0
FOXM1 transcription factor network	17.0	876.0	51.0	-0.163	0.029	1000.0	-1000.0	-0.189	-1000.0
Visual signal transduction: Cones	16.0	621.0	38.0	-0.054	0.007	1000.0	-1000.0	-0.034	-1000.0
Osteopontin-mediated events	16.0	629.0	38.0	-0.065	0.012	1000.0	-1000.0	-0.083	-1000.0
Calcium signaling in the CD4+ TCR pathway	15.0	481.0	31.0	-0.163	0.012	1000.0	-1000.0	-0.06	-1000.0
EGFR-dependent Endothelin signaling events	15.0	317.0	21.0	-0.065	0.018	1000.0	-1000.0	-0.06	-1000.0
Cellular roles of Anthrax toxin	14.0	580.0	39.0	-0.074	0.012	1000.0	-1000.0	-0.021	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1426.0	97.0	-0.068	0.025	1000.0	-1000.0	-0.074	-1000.0
Regulation of nuclear SMAD2/3 signaling	13.0	1815.0	136.0	-0.256	0.053	1000.0	-1000.0	-0.057	-1000.0
ErbB4 signaling events	13.0	935.0	69.0	-0.107	0.033	1000.0	-1000.0	-0.066	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	751.0	54.0	-0.144	0.024	1000.0	-1000.0	-0.083	-1000.0
a4b1 and a4b7 Integrin signaling	13.0	69.0	5.0	-0.013	0.001	1000.0	-1000.0	-0.011	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	13.0	503.0	37.0	-0.049	0.018	1000.0	-1000.0	-0.035	-1000.0
S1P1 pathway	13.0	492.0	36.0	-0.146	0.012	1000.0	-1000.0	-0.052	-1000.0
IL27-mediated signaling events	13.0	696.0	51.0	-0.086	0.025	1000.0	-1000.0	-0.081	-1000.0
Regulation of Androgen receptor activity	13.0	926.0	70.0	-0.154	0.024	1000.0	-1000.0	-0.057	-1000.0
Ceramide signaling pathway	12.0	928.0	76.0	-0.069	0.035	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class III	12.0	494.0	40.0	-0.133	0.024	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	12.0	601.0	48.0	-0.041	0.025	1000.0	-1000.0	-0.062	-1000.0
Syndecan-3-mediated signaling events	12.0	421.0	35.0	-0.094	0.032	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by PI3K	12.0	717.0	58.0	-0.083	0.019	1000.0	-1000.0	-0.082	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	12.0	554.0	45.0	-0.069	0.025	1000.0	-1000.0	-0.078	-1000.0
IL2 signaling events mediated by STAT5	12.0	267.0	22.0	-0.022	0.013	1000.0	-1000.0	-0.056	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	12.0	416.0	33.0	-0.156	0.036	1000.0	-1000.0	-0.036	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	210.0	17.0	-0.026	0.019	1000.0	-1000.0	-0.044	-1000.0
PLK2 and PLK4 events	11.0	34.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.018	-1000.0
JNK signaling in the CD4+ TCR pathway	11.0	195.0	17.0	-0.028	0.012	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	11.0	1171.0	102.0	-0.176	0.035	1000.0	-1000.0	-0.096	-1000.0
Hedgehog signaling events mediated by Gli proteins	10.0	650.0	65.0	-0.236	0.041	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by PRL	10.0	370.0	34.0	-0.115	0.02	1000.0	-1000.0	-0.027	-1000.0
S1P5 pathway	9.0	162.0	17.0	-0.029	0.012	1000.0	-1000.0	-0.031	-1000.0
TCGA08_rtk_signaling	9.0	248.0	26.0	-0.041	0.033	1000.0	-1000.0	-0.019	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	9.0	670.0	74.0	-0.079	0.05	1000.0	-1000.0	-0.076	-1000.0
ErbB2/ErbB3 signaling events	8.0	574.0	65.0	-0.048	0.02	1000.0	-1000.0	-0.056	-1000.0
BARD1 signaling events	8.0	466.0	57.0	-0.014	0.039	1000.0	-1000.0	-0.053	-1000.0
EPO signaling pathway	8.0	486.0	55.0	-0.038	0.025	1000.0	-1000.0	-0.076	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	679.0	83.0	-0.143	0.058	1000.0	-1000.0	-0.068	-1000.0
Signaling mediated by p38-gamma and p38-delta	8.0	130.0	15.0	-0.012	0.014	1000.0	-1000.0	-0.029	-1000.0
Class I PI3K signaling events	8.0	589.0	73.0	-0.071	0.03	1000.0	-1000.0	-0.058	-1000.0
S1P4 pathway	8.0	224.0	25.0	-0.029	0.018	1000.0	-1000.0	-0.031	-1000.0
p38 MAPK signaling pathway	8.0	363.0	44.0	-0.113	0.024	1000.0	-1000.0	-0.055	-1000.0
Aurora B signaling	8.0	548.0	67.0	-0.158	0.016	1000.0	-1000.0	-0.058	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	203.0	28.0	-0.029	0.03	1000.0	-1000.0	-0.028	-1000.0
IFN-gamma pathway	7.0	494.0	68.0	-0.113	0.035	1000.0	-1000.0	-0.088	-1000.0
ceramide signaling pathway	7.0	364.0	49.0	-0.069	0.018	1000.0	-1000.0	-0.045	-1000.0
mTOR signaling pathway	6.0	348.0	53.0	-0.022	0.016	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	6.0	297.0	43.0	-0.046	0.046	1000.0	-1000.0	-0.072	-1000.0
Paxillin-dependent events mediated by a4b1	6.0	223.0	36.0	-0.044	0.024	1000.0	-1000.0	-0.062	-1000.0
Insulin Pathway	6.0	516.0	74.0	-0.106	0.032	1000.0	-1000.0	-0.076	-1000.0
Rapid glucocorticoid signaling	6.0	121.0	20.0	-0.01	0.012	1000.0	-1000.0	-0.011	-1000.0
PDGFR-beta signaling pathway	6.0	607.0	97.0	-0.056	0.034	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class II	5.0	427.0	75.0	-0.059	0.033	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class I	5.0	548.0	104.0	-0.069	0.046	1000.0	-1000.0	-0.051	-1000.0
Regulation of p38-alpha and p38-beta	5.0	321.0	54.0	-0.071	0.032	1000.0	-1000.0	-0.056	-1000.0
S1P3 pathway	5.0	223.0	42.0	-0.013	0.021	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling events	5.0	26.0	5.0	0.002	0.016	1000.0	-1000.0	-0.018	-1000.0
Canonical NF-kappaB pathway	4.0	185.0	39.0	-0.069	0.059	1000.0	-1000.0	-0.075	-1000.0
Aurora C signaling	4.0	32.0	7.0	-0.004	0.011	1000.0	-1000.0	-0.029	-1000.0
Atypical NF-kappaB pathway	4.0	143.0	31.0	-0.018	0.029	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	512.0	125.0	-0.068	0.047	1000.0	-1000.0	-0.085	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	324.0	76.0	-0.023	0.041	1000.0	-1000.0	-0.076	-1000.0
E-cadherin signaling in keratinocytes	4.0	198.0	43.0	-0.018	0.024	1000.0	-1000.0	-0.041	-1000.0
Aurora A signaling	3.0	229.0	60.0	-0.03	0.031	1000.0	-1000.0	-0.028	-1000.0
Insulin-mediated glucose transport	3.0	100.0	32.0	-0.056	0.025	1000.0	-1000.0	-0.048	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	205.0	68.0	-0.056	0.039	1000.0	-1000.0	-0.044	-1000.0
FoxO family signaling	3.0	214.0	64.0	-0.076	0.097	1000.0	-1000.0	-0.068	-1000.0
VEGFR1 specific signals	3.0	188.0	56.0	-0.018	0.037	1000.0	-1000.0	-0.058	-1000.0
Circadian rhythm pathway	2.0	44.0	22.0	-0.012	0.039	1000.0	-1000.0	-0.034	-1000.0
Arf6 downstream pathway	2.0	102.0	43.0	-0.022	0.023	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	2.0	249.0	85.0	-0.017	0.03	1000.0	-1000.0	-0.033	-1000.0
Arf6 trafficking events	1.0	125.0	71.0	-0.035	0.035	1000.0	-1000.0	-0.064	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	21.0	23.0	0.003	0.04	1000.0	-1000.0	-0.041	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	16.0	27.0	-0.001	0.029	1000.0	-1000.0	-0.046	-1000.0
Arf1 pathway	0.0	46.0	54.0	-0.004	0.024	1000.0	-1000.0	-0.032	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.037	1000.0	-1000.0	-0.029	-1000.0
Total	2307	133554	7203	-14.1963064308	-995.40630311	131000	-131000	-7.49764661651	-131000