Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	48.0	386.0	8.0	-0.302	0.15	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	39.0	274.0	7.0	-0.229	0.115	1000.0	-1000.0	-0.017	-1000.0
Syndecan-1-mediated signaling events	30.0	1027.0	34.0	-0.272	0.013	1000.0	-1000.0	-0.057	-1000.0
IL23-mediated signaling events	27.0	1671.0	60.0	-0.686	0.013	1000.0	-1000.0	-0.164	-1000.0
IL4-mediated signaling events	24.0	2269.0	91.0	-0.644	0.575	1000.0	-1000.0	-0.133	-1000.0
Signaling events mediated by the Hedgehog family	23.0	1199.0	52.0	-0.205	0.203	1000.0	-1000.0	-0.06	-1000.0
Wnt signaling	22.0	159.0	7.0	-0.143	0.008	1000.0	-1000.0	-0.028	-1000.0
TCR signaling in naïve CD8+ T cells	21.0	2016.0	93.0	-0.233	0.102	1000.0	-1000.0	-0.08	-1000.0
IL12-mediated signaling events	20.0	1793.0	87.0	-0.39	0.09	1000.0	-1000.0	-0.126	-1000.0
Glypican 2 network	20.0	81.0	4.0	-0.081	-1000.0	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	17.0	1406.0	82.0	-0.206	0.013	1000.0	-1000.0	-0.086	-1000.0
Glucocorticoid receptor regulatory network	17.0	1999.0	114.0	-0.686	0.388	1000.0	-1000.0	-0.074	-1000.0
Syndecan-4-mediated signaling events	17.0	1171.0	67.0	-0.284	0.032	1000.0	-1000.0	-0.088	-1000.0
BMP receptor signaling	15.0	1241.0	81.0	-0.264	0.035	1000.0	-1000.0	-0.085	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	15.0	1063.0	68.0	-0.373	0.111	1000.0	-1000.0	-0.128	-1000.0
Noncanonical Wnt signaling pathway	14.0	369.0	26.0	-0.162	0.013	1000.0	-1000.0	-0.06	-1000.0
Signaling mediated by p38-alpha and p38-beta	14.0	651.0	44.0	-0.137	0.013	1000.0	-1000.0	-0.057	-1000.0
BCR signaling pathway	14.0	1455.0	99.0	-0.229	0.013	1000.0	-1000.0	-0.084	-1000.0
HIF-1-alpha transcription factor network	13.0	1045.0	76.0	-0.384	0.021	1000.0	-1000.0	-0.15	-1000.0
Reelin signaling pathway	13.0	749.0	56.0	-0.169	0.013	1000.0	-1000.0	-0.074	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	416.0	31.0	-0.257	0.013	1000.0	-1000.0	-0.086	-1000.0
Caspase cascade in apoptosis	12.0	953.0	74.0	-0.147	0.078	1000.0	-1000.0	-0.057	-1000.0
Thromboxane A2 receptor signaling	12.0	1312.0	105.0	-0.122	0.034	1000.0	-1000.0	-0.065	-1000.0
p75(NTR)-mediated signaling	12.0	1537.0	125.0	-0.254	0.013	1000.0	-1000.0	-0.094	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1190.0	97.0	-0.162	0.031	1000.0	-1000.0	-0.076	-1000.0
Class IB PI3K non-lipid kinase events	12.0	36.0	3.0	-0.044	-1000.0	1000.0	-1000.0	-0.016	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	11.0	375.0	34.0	-0.071	0.013	1000.0	-1000.0	-0.059	-1000.0
Glypican 1 network	11.0	558.0	48.0	-0.24	0.015	1000.0	-1000.0	-0.047	-1000.0
IL1-mediated signaling events	11.0	697.0	62.0	-0.193	0.063	1000.0	-1000.0	-0.089	-1000.0
Signaling events regulated by Ret tyrosine kinase	11.0	969.0	82.0	-0.133	0.013	1000.0	-1000.0	-0.082	-1000.0
IL27-mediated signaling events	11.0	603.0	51.0	-0.278	0.077	1000.0	-1000.0	-0.068	-1000.0
LPA receptor mediated events	10.0	1060.0	102.0	-0.157	0.022	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	10.0	781.0	75.0	-0.129	0.061	1000.0	-1000.0	-0.076	-1000.0
IGF1 pathway	10.0	600.0	57.0	-0.132	0.014	1000.0	-1000.0	-0.088	-1000.0
Visual signal transduction: Rods	10.0	569.0	52.0	-0.203	0.013	1000.0	-1000.0	-0.084	-1000.0
Coregulation of Androgen receptor activity	9.0	752.0	76.0	-0.346	0.024	1000.0	-1000.0	-0.038	-1000.0
Osteopontin-mediated events	9.0	379.0	38.0	-0.106	0.013	1000.0	-1000.0	-0.096	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	153.0	17.0	-0.082	0.013	1000.0	-1000.0	-0.058	-1000.0
Endothelins	9.0	910.0	96.0	-0.182	0.028	1000.0	-1000.0	-0.091	-1000.0
Nongenotropic Androgen signaling	9.0	501.0	52.0	-0.168	0.021	1000.0	-1000.0	-0.053	-1000.0
Rapid glucocorticoid signaling	9.0	185.0	20.0	-0.196	0.013	1000.0	-1000.0	-0.039	-1000.0
FOXM1 transcription factor network	9.0	461.0	51.0	-0.314	0.088	1000.0	-1000.0	-0.168	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	9.0	710.0	78.0	-0.093	0.058	1000.0	-1000.0	-0.074	-1000.0
Nectin adhesion pathway	8.0	506.0	63.0	-0.086	0.013	1000.0	-1000.0	-0.069	-1000.0
Integrins in angiogenesis	8.0	686.0	84.0	-0.183	0.013	1000.0	-1000.0	-0.098	-1000.0
EPHB forward signaling	8.0	694.0	85.0	-0.101	0.087	1000.0	-1000.0	-0.088	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	972.0	120.0	-0.202	0.166	1000.0	-1000.0	-0.068	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	136.0	17.0	-0.081	0.023	1000.0	-1000.0	-0.044	-1000.0
ErbB2/ErbB3 signaling events	7.0	489.0	65.0	-0.146	0.027	1000.0	-1000.0	-0.063	-1000.0
ErbB4 signaling events	7.0	513.0	69.0	-0.201	0.056	1000.0	-1000.0	-0.096	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	200.0	28.0	-0.086	0.013	1000.0	-1000.0	-0.038	-1000.0
Syndecan-2-mediated signaling events	7.0	551.0	69.0	-0.166	0.04	1000.0	-1000.0	-0.048	-1000.0
a4b1 and a4b7 Integrin signaling	7.0	38.0	5.0	-0.049	-0.019	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	7.0	463.0	62.0	-0.109	0.013	1000.0	-1000.0	-0.063	-1000.0
S1P5 pathway	7.0	128.0	17.0	-0.086	0.075	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	7.0	373.0	48.0	-0.085	0.068	1000.0	-1000.0	-0.08	-1000.0
S1P1 pathway	7.0	261.0	36.0	-0.087	0.013	1000.0	-1000.0	-0.057	-1000.0
Effects of Botulinum toxin	7.0	187.0	26.0	-0.087	0.013	1000.0	-1000.0	-0.06	-1000.0
EGFR-dependent Endothelin signaling events	7.0	161.0	21.0	-0.092	0.013	1000.0	-1000.0	-0.069	-1000.0
LPA4-mediated signaling events	6.0	82.0	12.0	-0.062	0.016	1000.0	-1000.0	-0.023	-1000.0
Visual signal transduction: Cones	6.0	234.0	38.0	-0.074	0.013	1000.0	-1000.0	-0.058	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	336.0	54.0	-0.178	0.026	1000.0	-1000.0	-0.101	-1000.0
Ephrin A  reverse signaling	6.0	43.0	7.0	-0.035	-0.0	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by PTP1B	6.0	471.0	76.0	-0.112	0.017	1000.0	-1000.0	-0.072	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	277.0	46.0	-0.294	0.02	1000.0	-1000.0	-0.078	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	357.0	52.0	-0.192	0.038	1000.0	-1000.0	-0.059	-1000.0
Syndecan-3-mediated signaling events	6.0	212.0	35.0	-0.197	0.013	1000.0	-1000.0	-0.066	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	477.0	74.0	-0.127	0.053	1000.0	-1000.0	-0.083	-1000.0
IL2 signaling events mediated by STAT5	6.0	139.0	22.0	-0.147	0.014	1000.0	-1000.0	-0.052	-1000.0
Plasma membrane estrogen receptor signaling	6.0	536.0	86.0	-0.127	0.019	1000.0	-1000.0	-0.078	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	542.0	88.0	-0.116	0.038	1000.0	-1000.0	-0.094	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	205.0	33.0	-0.309	0.037	1000.0	-1000.0	-0.056	-1000.0
S1P4 pathway	6.0	166.0	25.0	-0.086	0.013	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	6.0	430.0	70.0	-0.379	0.023	1000.0	-1000.0	-0.068	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	786.0	136.0	-0.227	0.071	1000.0	-1000.0	-0.069	-1000.0
PDGFR-alpha signaling pathway	5.0	243.0	44.0	-0.047	0.021	1000.0	-1000.0	-0.052	-1000.0
FAS signaling pathway (CD95)	5.0	266.0	47.0	-0.188	0.014	1000.0	-1000.0	-0.048	-1000.0
IL2 signaling events mediated by PI3K	5.0	304.0	58.0	-0.125	0.032	1000.0	-1000.0	-0.077	-1000.0
BARD1 signaling events	4.0	240.0	57.0	-0.044	0.045	1000.0	-1000.0	-0.061	-1000.0
Cellular roles of Anthrax toxin	4.0	187.0	39.0	-0.086	0.017	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	159.0	37.0	-0.049	0.013	1000.0	-1000.0	-0.053	-1000.0
TRAIL signaling pathway	4.0	197.0	48.0	-0.037	0.033	1000.0	-1000.0	-0.06	-1000.0
HIF-2-alpha transcription factor network	4.0	210.0	43.0	-0.051	0.058	1000.0	-1000.0	-0.09	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	60.0	15.0	-0.03	0.021	1000.0	-1000.0	-0.032	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	196.0	45.0	-0.082	0.03	1000.0	-1000.0	-0.083	-1000.0
Canonical Wnt signaling pathway	4.0	237.0	51.0	-0.127	0.064	1000.0	-1000.0	-0.06	-1000.0
S1P3 pathway	4.0	204.0	42.0	-0.085	0.023	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	4.0	189.0	43.0	-0.055	0.033	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling events	4.0	21.0	5.0	-0.027	0.013	1000.0	-1000.0	-0.039	-1000.0
Aurora B signaling	4.0	278.0	67.0	-0.183	0.015	1000.0	-1000.0	-0.063	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	269.0	85.0	-0.109	0.022	1000.0	-1000.0	-0.07	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	237.0	65.0	-0.086	0.058	1000.0	-1000.0	-0.057	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	243.0	61.0	-0.111	0.036	1000.0	-1000.0	-0.068	-1000.0
IFN-gamma pathway	3.0	255.0	68.0	-0.08	0.03	1000.0	-1000.0	-0.089	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	115.0	36.0	-0.049	0.023	1000.0	-1000.0	-0.066	-1000.0
Regulation of p38-alpha and p38-beta	3.0	199.0	54.0	-0.077	0.013	1000.0	-1000.0	-0.056	-1000.0
TCGA08_rtk_signaling	3.0	80.0	26.0	-0.065	0.031	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	271.0	76.0	-0.057	0.039	1000.0	-1000.0	-0.075	-1000.0
Class I PI3K signaling events	3.0	284.0	73.0	-0.077	0.037	1000.0	-1000.0	-0.061	-1000.0
Regulation of Telomerase	3.0	398.0	102.0	-0.169	0.042	1000.0	-1000.0	-0.103	-1000.0
Insulin Pathway	3.0	226.0	74.0	-0.087	0.035	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by HDAC Class II	2.0	168.0	75.0	-0.064	0.03	1000.0	-1000.0	-0.061	-1000.0
Aurora C signaling	2.0	15.0	7.0	-0.021	-0.0	1000.0	-1000.0	-0.04	-1000.0
Ceramide signaling pathway	2.0	215.0	76.0	-0.127	0.023	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class III	2.0	97.0	40.0	-0.116	0.021	1000.0	-1000.0	-0.049	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	223.0	83.0	-0.11	0.045	1000.0	-1000.0	-0.068	-1000.0
Retinoic acid receptors-mediated signaling	2.0	140.0	58.0	-0.04	0.04	1000.0	-1000.0	-0.072	-1000.0
Atypical NF-kappaB pathway	2.0	65.0	31.0	-0.029	0.029	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	283.0	125.0	-0.037	0.067	1000.0	-1000.0	-0.092	-1000.0
PDGFR-beta signaling pathway	2.0	279.0	97.0	-0.058	0.056	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by PRL	2.0	68.0	34.0	-0.097	0.031	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	2.0	93.0	44.0	-0.074	0.022	1000.0	-1000.0	-0.066	-1000.0
Canonical NF-kappaB pathway	1.0	76.0	39.0	-0.059	0.068	1000.0	-1000.0	-0.081	-1000.0
Circadian rhythm pathway	1.0	22.0	22.0	-0.028	0.043	1000.0	-1000.0	-0.044	-1000.0
Aurora A signaling	1.0	87.0	60.0	-0.036	0.031	1000.0	-1000.0	-0.055	-1000.0
Arf6 downstream pathway	1.0	50.0	43.0	-0.022	0.026	1000.0	-1000.0	-0.039	-1000.0
EPO signaling pathway	1.0	108.0	55.0	-0.049	0.054	1000.0	-1000.0	-0.091	-1000.0
PLK1 signaling events	1.0	98.0	85.0	-0.013	0.03	1000.0	-1000.0	-0.05	-1000.0
Insulin-mediated glucose transport	1.0	35.0	32.0	-0.033	0.031	1000.0	-1000.0	-0.059	-1000.0
mTOR signaling pathway	1.0	58.0	53.0	-0.011	0.029	1000.0	-1000.0	-0.054	-1000.0
ceramide signaling pathway	1.0	71.0	49.0	-0.059	0.029	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by HDAC Class I	1.0	163.0	104.0	-0.106	0.055	1000.0	-1000.0	-0.066	-1000.0
Arf6 trafficking events	1.0	97.0	71.0	-0.062	0.043	1000.0	-1000.0	-0.066	-1000.0
VEGFR1 specific signals	1.0	94.0	56.0	-0.026	0.053	1000.0	-1000.0	-0.068	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	-0.011	0.045	1000.0	-1000.0	-0.06	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.01	0.02	1000.0	-1000.0	-0.019	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	38.0	68.0	-0.035	0.048	1000.0	-1000.0	-0.049	-1000.0
FoxO family signaling	0.0	53.0	64.0	-0.07	0.135	1000.0	-1000.0	-0.064	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.014	0.033	1000.0	-1000.0	-0.055	-1000.0
Arf1 pathway	0.0	11.0	54.0	-0.012	0.028	1000.0	-1000.0	-0.048	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.004	0.013	1000.0	-1000.0	-0.054	-1000.0
Total	1005	57677	7203	-18.1916681942	-1994.37235626	131000	-131000	-8.678738245	-131000