Molecular subtypes CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Amp Peak 1(1p36.22) 0 (0%) 270 1.1915e-07 4.53e-05 0.0039642 0.848 0.021053 1 0.0056724 1 0.71777 1 0.08942 1 Amp Peak 2(1q21.3) 0 (0%) 198 4.5492e-20 2.02e-17 5.0363e-11 2.08e-08 3.2774e-08 1.26e-05 3.6008e-05 0.0114 1.3137e-05 0.0044 1.7765e-05 0.00588 Amp Peak 3(1q42.3) 0 (0%) 201 5.5225e-14 2.38e-11 1.1055e-07 4.21e-05 4.4874e-07 0.000166 0.00046219 0.13 1.5794e-06 0.000569 1.7747e-06 0.000637 Amp Peak 4(3q27.1) 0 (0%) 203 1.2062e-05 0.00405 0.0074151 1 0.21476 1 0.86519 1 0.60745 1 0.045712 1 Amp Peak 5(5p13.1) 0 (0%) 219 1.645e-14 7.14e-12 5.6849e-07 0.000209 2.7225e-05 0.00879 0.017478 1 0.022591 1 0.0040732 0.864 Amp Peak 6(6p21.1) 0 (0%) 226 3.0956e-17 1.37e-14 5.9902e-10 2.41e-07 0.0008072 0.216 0.003411 0.747 0.0099823 1 2.4515e-05 0.00799 Amp Peak 7(6q12) 0 (0%) 246 2.9755e-09 1.18e-06 1.6867e-08 6.53e-06 0.00024453 0.0726 0.011234 1 0.045998 1 0.00026315 0.0776 Amp Peak 8(6q21) 0 (0%) 250 4.3813e-09 1.73e-06 2.7411e-05 0.00883 0.0068012 1 0.021988 1 0.24656 1 0.0042689 0.901 Amp Peak 9(7p22.3) 0 (0%) 149 8.2502e-14 3.55e-11 3.1992e-05 0.0102 0.021678 1 0.1184 1 0.08296 1 0.0057019 1 Amp Peak 10(7p11.2) 0 (0%) 163 4.2298e-12 1.77e-09 0.014477 1 0.080712 1 0.47313 1 0.26724 1 0.027392 1 Amp Peak 11(7q21.2) 0 (0%) 169 2.3593e-11 9.81e-09 0.024931 1 0.38446 1 0.26697 1 0.46629 1 0.30845 1 Amp Peak 12(8p23.1) 0 (0%) 185 3.3948e-13 1.45e-10 0.0017362 0.417 0.45578 1 0.012403 1 0.75308 1 0.19633 1 Amp Peak 13(8q24.21) 0 (0%) 101 2.6319e-06 0.000932 0.00010088 0.0313 0.1547 1 0.21056 1 0.27306 1 0.0015849 0.384 Amp Peak 14(9p24.1) 0 (0%) 257 0.36393 1 0.1017 1 0.64984 1 0.26877 1 0.79151 1 0.27258 1 Amp Peak 15(9q34.3) 0 (0%) 232 2.8621e-07 0.000107 0.0077531 1 0.0097488 1 0.01404 1 0.13889 1 0.21444 1 Amp Peak 16(10q22.2) 0 (0%) 250 9.4116e-08 3.6e-05 0.074764 1 0.00079566 0.213 0.0025222 0.57 0.17437 1 0.028321 1 Amp Peak 17(10q26.13) 0 (0%) 245 1.1825e-05 0.004 0.00075388 0.204 0.00092879 0.244 0.057276 1 0.62404 1 0.018278 1 Amp Peak 18(11p13) 0 (0%) 252 0.0065816 1 0.10934 1 0.0051604 1 0.0053698 1 0.18671 1 0.00065454 0.178 Amp Peak 19(11q13.3) 0 (0%) 238 3.2708e-05 0.0104 0.18845 1 0.21013 1 0.66293 1 0.001985 0.464 0.021629 1 Amp Peak 20(12p12.1) 0 (0%) 220 0.00030362 0.0877 0.018439 1 0.3428 1 0.9765 1 0.75873 1 0.39721 1 Amp Peak 21(12q15) 0 (0%) 229 0.0080306 1 0.00027814 0.0812 0.17144 1 0.42918 1 0.59632 1 0.28178 1 Amp Peak 22(13q12.3) 0 (0%) 190 7.0689e-10 2.83e-07 1.4533e-05 0.00485 0.1485 1 0.17992 1 0.28131 1 0.0022713 0.522 Amp Peak 23(13q22.1) 0 (0%) 185 1.5441e-08 5.99e-06 3.7434e-05 0.0118 0.013263 1 0.13028 1 0.53216 1 1.9975e-06 0.000715 Amp Peak 24(15q26.1) 0 (0%) 237 1.0316e-13 4.43e-11 0.00041025 0.116 0.0001364 0.0416 7.5324e-06 0.00258 0.20968 1 0.19607 1 Amp Peak 25(17q12) 0 (0%) 214 9.5399e-13 4.04e-10 8.0711e-06 0.00276 6.8536e-06 0.00236 0.0017925 0.428 0.02333 1 0.0009961 0.258 Amp Peak 26(18q11.2) 0 (0%) 216 3.3105e-06 0.00117 0.00022986 0.0687 0.041332 1 0.073331 1 0.29098 1 0.097378 1 Amp Peak 27(19q12) 0 (0%) 216 1.6674e-15 7.32e-13 4.6635e-10 1.88e-07 8.371e-11 3.43e-08 4.5943e-06 0.00161 0.00030541 0.088 1.7095e-10 6.94e-08 Amp Peak 28(20q13.2) 0 (0%) 105 5.6288e-21 2.51e-18 2.0562e-11 8.57e-09 6.8739e-07 0.000252 0.0082821 1 0.014119 1 8.8943e-09 3.5e-06 Amp Peak 29(Xq27.3) 0 (0%) 246 0.00015507 0.047 0.22341 1 0.051906 1 0.34612 1 0.25881 1 0.80311 1 Del Peak 1(1p36.11) 0 (0%) 223 4.2015e-15 1.84e-12 0.00036578 0.104 0.001487 0.367 0.0024081 0.549 0.0019508 0.458 0.0057589 1 Del Peak 2(1p13.2) 0 (0%) 247 5.3952e-12 2.26e-09 0.0010648 0.274 0.012739 1 0.021988 1 0.025451 1 0.015924 1 Del Peak 3(1q44) 0 (0%) 283 0.018536 1 0.010034 1 0.55034 1 0.73184 1 0.42005 1 0.31748 1 Del Peak 4(2q32.1) 0 (0%) 264 0.0089459 1 0.12042 1 0.3653 1 0.92935 1 0.084946 1 0.22743 1 Del Peak 5(2q37.2) 0 (0%) 259 0.0001908 0.0572 0.003934 0.846 0.061206 1 0.16274 1 0.0028526 0.633 0.00099133 0.258 Del Peak 6(3p26.1) 0 (0%) 222 2.6431e-10 1.07e-07 0.0002996 0.0869 0.10663 1 0.16642 1 0.23864 1 0.00051675 0.143 Del Peak 7(3p14.2) 0 (0%) 204 9.3271e-13 3.95e-10 1.3783e-06 0.000498 0.0036726 0.797 0.0018685 0.441 0.09814 1 3.6522e-05 0.0115 Del Peak 8(3q26.31) 0 (0%) 272 4.23e-06 0.00148 8.437e-05 0.0262 0.00095604 0.25 0.0067486 1 0.016298 1 0.0018299 0.434 Del Peak 9(4p16.3) 0 (0%) 194 2.8949e-10 1.17e-07 0.00037683 0.107 0.00026626 0.078 0.006998 1 0.00084783 0.225 3.0718e-05 0.00983 Del Peak 10(4q22.1) 0 (0%) 171 6.7225e-19 2.98e-16 1.2304e-07 4.66e-05 0.021301 1 0.031947 1 0.0032542 0.716 0.00010155 0.0314 Del Peak 11(4q34.3) 0 (0%) 179 1.0706e-14 4.66e-12 7.5677e-07 0.000276 0.00074579 0.202 0.017668 1 0.0116 1 9.156e-06 0.00312 Del Peak 12(5q11.2) 0 (0%) 203 6.544e-28 2.94e-25 1.2707e-13 5.44e-11 9.4789e-07 0.000343 3.0589e-07 0.000114 2.917e-07 0.000109 2.5316e-09 1.01e-06 Del Peak 13(5q23.2) 0 (0%) 213 2.4759e-23 1.11e-20 2.4963e-12 1.05e-09 2.0165e-07 7.62e-05 2.0671e-06 0.000738 2.6505e-07 9.94e-05 1.1125e-08 4.35e-06 Del Peak 14(6p25.3) 0 (0%) 237 5.0068e-07 0.000185 0.00093203 0.244 0.017376 1 0.0023034 0.527 0.097621 1 0.00091492 0.242 Del Peak 15(6q26) 0 (0%) 244 0.00012761 0.039 0.059143 1 1.5086e-05 0.00502 0.0089533 1 0.38852 1 0.077228 1 Del Peak 16(7q31.1) 0 (0%) 262 3.1075e-07 0.000115 0.0014149 0.351 0.14092 1 0.51982 1 0.0063411 1 0.15199 1 Del Peak 17(7q36.3) 0 (0%) 248 1.8187e-14 7.88e-12 1.934e-05 0.00636 0.00079147 0.213 0.0055357 1 0.12257 1 0.00011334 0.0349 Del Peak 18(8p23.2) 0 (0%) 229 4.3014e-14 1.86e-11 5.7835e-06 0.00201 0.00054297 0.149 0.0015595 0.381 0.13379 1 0.00015979 0.0483 Del Peak 19(9p23) 0 (0%) 186 2.6605e-15 1.17e-12 2.8767e-05 0.00923 0.00031974 0.0918 0.034672 1 0.080125 1 0.0020873 0.482 Del Peak 20(9p21.3) 0 (0%) 188 6.2942e-16 2.77e-13 5.3489e-11 2.2e-08 3.0003e-06 0.00106 0.0020523 0.478 0.026253 1 0.00025989 0.0769 Del Peak 21(9q21.11) 0 (0%) 233 2.9745e-08 1.15e-05 0.00016283 0.049 0.083975 1 0.24343 1 0.042731 1 0.0036729 0.797 Del Peak 22(10p15.1) 0 (0%) 268 0.00012398 0.0381 0.18 1 0.34927 1 0.49694 1 0.2648 1 0.10288 1 Del Peak 23(10q22.3) 0 (0%) 257 2.4321e-09 9.68e-07 0.0011313 0.285 0.082876 1 0.066936 1 0.052493 1 0.00064101 0.176 Del Peak 24(10q23.31) 0 (0%) 233 2.7184e-12 1.14e-09 1.1974e-05 0.00404 0.14379 1 0.13853 1 0.0028734 0.635 2.5138e-05 0.00817 Del Peak 25(11p15.4) 0 (0%) 247 2.9626e-08 1.14e-05 1.5512e-05 0.00515 0.077231 1 0.026159 1 0.70692 1 0.030343 1 Del Peak 26(11q23.2) 0 (0%) 244 0.0002643 0.0777 0.0024828 0.564 0.0015444 0.38 0.70116 1 0.4878 1 0.77933 1 Del Peak 27(12p13.31) 0 (0%) 256 1.4888e-10 6.06e-08 1.1259e-05 0.00382 2.6617e-05 0.00862 0.00028078 0.0817 0.067877 1 0.02868 1 Del Peak 28(13q12.11) 0 (0%) 262 2.323e-06 0.000827 0.071532 1 0.069513 1 0.1181 1 0.74605 1 0.13985 1 Del Peak 29(14q21.1) 0 (0%) 235 7.6857e-07 0.00028 0.0045647 0.949 0.0043278 0.909 0.0020566 0.478 0.019779 1 0.0015785 0.384 Del Peak 30(14q32.33) 0 (0%) 217 9.2439e-09 3.62e-06 0.014963 1 0.036209 1 0.0013218 0.33 0.023024 1 0.11733 1 Del Peak 31(15q15.1) 0 (0%) 227 6.4387e-13 2.74e-10 5.7148e-07 0.00021 1.7947e-05 0.00592 7.3772e-06 0.00254 0.0013222 0.33 8.7334e-07 0.000317 Del Peak 32(16p13.3) 0 (0%) 248 7.4186e-11 3.05e-08 7.0327e-05 0.0219 2.0339e-05 0.00665 0.0003825 0.108 0.0048887 1 0.018532 1 Del Peak 33(16q23.1) 0 (0%) 188 2.2174e-07 8.34e-05 0.0047063 0.974 0.02264 1 0.0043333 0.909 0.66686 1 0.13214 1 Del Peak 34(17p12) 0 (0%) 191 1.8098e-23 8.11e-21 4.4433e-11 1.84e-08 9.9546e-06 0.00338 1.9628e-05 0.00644 0.0028391 0.633 6.3568e-06 0.00221 Del Peak 35(17q24.3) 0 (0%) 251 1.3158e-10 5.38e-08 0.00023714 0.0707 0.00046333 0.13 0.0018222 0.434 0.024564 1 0.014377 1 Del Peak 36(18q21.2) 0 (0%) 173 4.4882e-13 1.91e-10 0.00084642 0.225 0.01414 1 0.15166 1 0.13442 1 0.0063203 1 Del Peak 37(19p13.3) 0 (0%) 207 2.3542e-27 1.06e-24 2.383e-16 1.05e-13 3.6224e-11 1.5e-08 1.3364e-12 5.64e-10 2.2058e-07 8.32e-05 1.0584e-19 4.7e-17 Del Peak 38(19q13.11) 0 (0%) 263 2.6898e-09 1.07e-06 6.1627e-05 0.0193 0.0142 1 0.0015486 0.38 0.016533 1 2.4397e-06 0.000866 Del Peak 39(20p12.1) 0 (0%) 254 1.2075e-08 4.71e-06 0.0011192 0.284 0.0010675 0.274 0.018236 1 0.19742 1 0.0026923 0.606 Del Peak 40(20p12.1) 0 (0%) 254 1.2075e-08 4.71e-06 0.0011192 0.284 0.0010675 0.274 0.018236 1 0.19742 1 0.0026923 0.606 Del Peak 41(21q11.2) 0 (0%) 198 1.3864e-10 5.66e-08 5.4096e-05 0.017 0.0053767 1 0.00034112 0.0976 0.019675 1 0.001156 0.29 Del Peak 42(21q22.13) 0 (0%) 191 1.5619e-09 6.23e-07 0.0005092 0.142 0.0050736 1 0.0010383 0.268 0.34034 1 0.0016973 0.409 Del Peak 43(22q13.31) 0 (0%) 205 9.6794e-15 4.22e-12 0.00014182 0.0431 0.0005285 0.146 0.00047071 0.131 0.006549 1 6.5625e-06 0.00227 Del Peak 44(Xp22.2) 0 (0%) 245 1.4414e-09 5.77e-07 0.00064166 0.176 0.003964 0.848 0.012752 1 0.17319 1 0.030626 1 Del Peak 45(Xp21.1) 0 (0%) 254 6.2238e-08 2.38e-05 0.0047065 0.974 0.24346 1 0.09401 1 0.53765 1 0.80697 1 Del Peak 46(Xq21.33) 0 (0%) 264 5.7705e-06 0.00201 0.04207 1 0.1617 1 0.17435 1 0.0036536 0.796 0.037709 1