rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5), CYP2C9(1)	653807	6	6	6	0	3	1	0	1	1	0	0.209	0.000101	0.0624
2	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3)	2546874	17	11	17	4	4	5	1	5	2	0	0.245	0.00235	0.723
3	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	3275210	19	10	19	2	4	4	3	6	2	0	0.0588	0.00459	0.942
4	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(1), FMOD(1), KERA(2), LUM(2)	1171353	8	7	8	3	1	1	2	4	0	0	0.701	0.0228	1.000
5	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CDKN1B(1), CUL1(1), E2F1(1), RB1(4), SKP2(2), UBE2M(1)	2767786	11	8	11	1	1	1	4	1	4	0	0.172	0.0256	1.000
6	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CSF1R(3), EGF(3), MET(6), PDGFRA(8), PRKCA(3), SH3GLB1(3), SH3KBP1(3)	5420381	29	13	28	8	9	5	4	6	4	1	0.209	0.0262	1.000
7	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(1), AGPS(2), ENPP2(2), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(4), PPAP2A(2), PPAP2C(1)	7485397	32	16	32	7	5	6	6	12	3	0	0.159	0.0273	1.000
8	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDC34(1), CDK2(1), CUL1(1), E2F1(1), RB1(4), SKP2(2)	2759061	11	8	11	1	1	1	4	1	4	0	0.191	0.0293	1.000
9	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(2), PLCG1(6), PRKCA(3), VAV1(4)	2922753	16	11	15	3	4	3	2	5	1	1	0.241	0.0417	1.000
10	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), NAT1(1), NAT2(2), XDH(7)	2572389	12	7	12	0	4	1	0	5	2	0	0.0358	0.0645	1.000
11	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(4), GLS(1), GLUD1(3), GOT1(2)	2521536	12	6	12	2	1	2	0	5	4	0	0.440	0.0688	1.000
12	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CYP2C19(5), CYP2C9(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3)	9970735	45	19	43	9	18	7	3	7	10	0	0.0670	0.0726	1.000
13	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), TYR(4)	3128061	10	7	10	1	2	1	1	4	2	0	0.236	0.0859	1.000
14	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(5), MPO(2), PRDX1(1), TPO(4), TYR(4)	3115761	18	10	18	4	7	5	0	5	1	0	0.110	0.0934	1.000
15	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(2), ITGA4(2), ITGAL(2), ITGB1(2), ITGB2(1), SELE(4)	3915038	15	11	14	4	7	5	2	1	0	0	0.223	0.0952	1.000
16	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(2), HGD(3)	720054	6	3	6	1	2	0	0	1	3	0	0.417	0.0960	1.000
17	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(1), PC(1), PDHA1(2), SLC25A1(1)	2996746	8	7	8	0	1	2	0	3	2	0	0.0677	0.100	1.000
18	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(1), CYP1A2(2), CYP2C19(5), CYP2C8(1), CYP2C9(1), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7714941	25	18	25	5	8	5	3	5	4	0	0.169	0.107	1.000
19	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(1), ELK1(3), INSR(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(1), SRF(2)	7014697	27	15	26	7	6	7	1	8	4	1	0.222	0.120	1.000
20	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CFL1(1), LIMK1(2), MAP3K1(2), MYL2(1), MYLK(3), NCF2(3), PAK1(2), PDGFRA(8), PLD1(4), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(4), VAV1(4), WASF1(1)	10067465	38	20	37	8	8	8	6	6	10	0	0.0532	0.124	1.000
21	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CRY1(3), CSNK1E(1), PER1(4)	2757941	10	6	10	1	2	3	1	2	2	0	0.215	0.125	1.000
22	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CDK2(1), CUL1(1), E2F1(1), FBXW7(1), RB1(4)	2665150	9	6	9	1	1	1	2	1	4	0	0.326	0.158	1.000
23	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(3), PFKL(3), PGAM1(1), PKLR(1), TPI1(1)	2997749	14	7	14	0	6	5	0	2	1	0	0.00219	0.160	1.000
24	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP19(2), SRP68(2), SRP72(3), SRPR(3)	2439245	10	5	9	1	3	0	3	2	2	0	0.225	0.162	1.000
25	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS1(2), PTGS2(2)	1726413	6	5	6	0	3	0	0	2	1	0	0.263	0.164	1.000
26	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1)	4700036	17	8	17	0	1	6	3	5	2	0	0.00418	0.174	1.000
27	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(4), CDC25A(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(3), RB1(4), WEE1(1), YWHAH(1)	5416177	19	9	19	7	3	2	3	2	9	0	0.766	0.183	1.000
28	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2)	4287321	24	11	24	7	9	1	3	9	2	0	0.321	0.196	1.000
29	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2)	1825247	10	5	10	4	1	0	2	7	0	0	0.747	0.197	1.000
30	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(1), TYR(4)	4853521	14	8	14	2	2	3	1	5	3	0	0.238	0.206	1.000
31	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(2), TAT(1), TYR(4)	1522383	8	5	8	3	3	0	1	4	0	0	0.754	0.208	1.000
32	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(2)	766698	4	3	4	1	1	0	0	3	0	0	0.634	0.216	1.000
33	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(2), GAD2(1), GGT1(2)	1858698	5	4	5	0	2	1	1	1	0	0	0.162	0.230	1.000
34	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL4(2)	2319950	11	6	11	2	4	0	2	3	2	0	0.280	0.230	1.000
35	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT2(2), FUT5(2), FUT6(2)	1633390	7	4	7	2	3	1	1	1	1	0	0.573	0.236	1.000
36	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3D(1), CTLA4(1), HLA-DRA(2), ITK(1), PTPN11(6)	2915323	12	9	11	4	3	1	1	7	0	0	0.628	0.240	1.000
37	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), LPO(5), MPO(2), TPO(4)	2700355	13	8	13	4	6	5	0	2	0	0	0.236	0.250	1.000
38	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(3), PDHA1(2), PDHA2(4)	2248485	11	6	11	2	2	5	1	1	2	0	0.137	0.259	1.000
39	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(2), ITGAL(2), ITGAM(1), ITGB2(1), SELE(4)	3356078	12	9	11	4	6	5	1	0	0	0	0.316	0.263	1.000
40	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(1), COQ6(1), NDUFB11(1)	1297311	4	3	4	0	0	2	0	2	0	0	0.310	0.271	1.000
41	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(4), RXRA(1)	1756224	5	4	4	1	2	1	2	0	0	0	0.372	0.273	1.000
42	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(4), SP3(2)	2150383	6	4	6	0	1	0	1	1	3	0	0.248	0.273	1.000
43	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), OXCT1(1), PDHA1(2), PDHA2(4)	8339501	30	15	30	8	11	7	2	5	5	0	0.123	0.274	1.000
44	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD1(3), GLUD2(1)	1468655	5	4	5	2	0	2	0	2	1	0	0.734	0.276	1.000
45	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(1), JAK2(3), MAPK3(1), MPL(2), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), STAT1(2), STAT3(1), STAT5B(2)	8459261	28	15	27	4	6	3	2	8	6	3	0.0708	0.288	1.000
46	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3), ERBB3(2), NRG1(2)	2475288	7	5	7	1	5	0	0	1	1	0	0.411	0.290	1.000
47	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(2)	1238207	4	3	4	1	0	1	2	0	1	0	0.624	0.292	1.000
48	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(8), DFFA(1), HMGB2(1), PRF1(1), SET(1)	3412916	13	6	13	3	4	1	2	4	2	0	0.369	0.294	1.000
49	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(2), ITGA4(2), ITGAL(2), ITGAM(1), ITGB1(2), ITGB2(1), SELE(4), SELP(2)	5156494	18	12	17	6	7	5	3	3	0	0	0.387	0.294	1.000
50	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(2), P2RY1(1), P2RY2(3), P2RY6(2)	1927163	10	4	10	4	5	2	1	2	0	0	0.525	0.307	1.000
51	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(4), BAX(1), CCND1(1), CDK2(1), CDK4(1), E2F1(1), MDM2(2), RB1(4), TIMP3(2)	5581803	18	8	18	4	3	2	5	4	4	0	0.283	0.308	1.000
52	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1)	11959032	39	20	38	7	11	10	4	9	5	0	0.0269	0.311	1.000
53	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	852041	3	2	3	1	1	0	1	1	0	0	0.728	0.317	1.000
54	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1), ACADS(1), ECHS1(2)	1745659	5	3	5	2	1	2	0	1	1	0	0.657	0.321	1.000
55	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), IDI1(1), SQLE(1)	1020417	3	2	3	0	0	0	3	0	0	0	0.337	0.339	1.000
56	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(3)	1597740	6	3	6	1	2	0	1	2	0	1	0.394	0.350	1.000
57	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), GRM1(5), PLCB1(2), PPP2CA(3), PPP3CA(1), PRKAR1A(1)	5180963	13	8	13	3	2	1	0	8	2	0	0.636	0.355	1.000
58	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4)	2584447	12	7	12	4	6	2	1	1	2	0	0.384	0.361	1.000
59	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4)	2584447	12	7	12	4	6	2	1	1	2	0	0.384	0.361	1.000
60	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(1), EGF(3), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1)	10035619	32	16	31	7	9	6	2	7	5	3	0.143	0.370	1.000
61	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(3), FDFT1(1), HMGCS1(1), IDI1(1), MVD(2), NSDHL(2), SC4MOL(1), SQLE(1)	4261561	13	6	13	4	5	1	4	3	0	0	0.402	0.371	1.000
62	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(1), ADCY4(4), CACNA1A(1), CACNA1B(7), GNAS(3), GRM4(2), ITPR3(6), KCNB1(3), PDE1A(1), PLCB2(2), SCNN1B(2), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(2), TAS2R13(1), TAS2R16(2), TAS2R3(1), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R9(4), TRPM5(2)	18333193	57	30	57	10	20	10	3	15	9	0	0.0132	0.377	1.000
63	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(5), ACAT2(1), ACSS1(1), ACSS2(3), ACYP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1)	15137114	48	24	47	10	16	11	5	10	6	0	0.0300	0.378	1.000
64	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), PANK2(1), PANK4(3)	4495741	12	7	12	3	2	2	0	5	3	0	0.636	0.385	1.000
65	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCNB1(1), CCND1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), E2F1(1), RB1(4), RBL1(2)	5189495	19	9	19	4	4	3	5	3	4	0	0.225	0.386	1.000
66	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(4), SP3(2), WT1(1)	2012076	7	4	6	0	3	1	0	3	0	0	0.0990	0.392	1.000
67	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(2), SHMT1(1)	1343926	4	3	4	1	2	1	1	0	0	0	0.431	0.394	1.000
68	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3)	682759	3	2	3	0	1	1	0	1	0	0	0.365	0.405	1.000
69	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), UGDH(1)	2757942	14	7	14	3	8	2	1	1	2	0	0.161	0.405	1.000
70	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(1), LEPR(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1)	4680350	19	7	18	2	4	2	2	9	2	0	0.0922	0.408	1.000
71	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), HLA-DRA(2)	983662	4	2	4	1	0	0	0	3	1	0	0.674	0.409	1.000
72	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(3), ACO1(2), ACO2(2), ACSS1(1), ACSS2(3), FH(1)	3768263	12	6	12	0	5	2	0	3	2	0	0.0115	0.412	1.000
73	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(3), PRKAR1A(1), PRKCA(3)	3080513	9	6	9	2	2	0	1	4	1	1	0.621	0.416	1.000
74	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT3(1), AGPS(2), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GNPAT(1), LGALS13(2), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(2), PLCG1(6), PLCG2(6), PPAP2A(2), PPAP2C(1)	16131996	59	29	58	14	22	12	6	12	7	0	0.0601	0.417	1.000
75	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	1094396	2	2	2	0	0	1	0	1	0	0	0.592	0.420	1.000
76	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(1), UXS1(2)	1578105	5	3	5	1	0	1	2	1	1	0	0.552	0.422	1.000
77	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3)	8065561	35	12	33	8	7	4	3	15	6	0	0.359	0.427	1.000
78	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(2), ADRB2(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), DRD3(1), DRD5(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1)	8262333	31	15	31	9	9	5	4	6	7	0	0.166	0.430	1.000
79	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), E2F1(1), MAPK1(1), MAPK3(1), NFKB1(1), PAK1(2), RAC1(1), RAF1(1), RB1(4), RELA(1)	5309863	18	7	18	6	4	2	3	1	7	1	0.551	0.431	1.000
80	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), HTR2C(1), PLCB1(2), TUB(2)	2310706	6	4	6	2	2	1	0	2	1	0	0.574	0.441	1.000
81	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1)	5645997	29	12	29	9	8	3	3	10	5	0	0.388	0.442	1.000
82	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(2), INSR(3), IRS1(2), JAK2(3), MAPK1(1), MAPK3(1), PLCG1(6), PRKCA(3), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(1), SRF(2), STAT5B(2)	9458396	32	15	31	7	5	8	3	9	5	2	0.119	0.450	1.000
83	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CDC25A(1), CHEK1(3), MYT1(3), WEE1(1), YWHAH(1)	4448818	13	6	13	7	2	2	1	2	6	0	0.920	0.455	1.000
84	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACADS(1), ACAT2(1), ACSM1(3), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), ILVBL(3), OXCT1(1), PDHA1(2), PDHA2(4), PLA1A(2)	13107506	48	20	48	11	17	9	4	11	7	0	0.0548	0.455	1.000
85	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), PON1(2), PON3(1)	2901622	9	5	8	2	5	0	0	1	3	0	0.457	0.457	1.000
86	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2)	5682954	15	9	15	4	3	1	4	6	1	0	0.357	0.462	1.000
87	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), HLA-DRA(2), IFNB1(1), IL12B(2), IL15(2), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1)	4245161	13	8	13	2	3	0	3	6	1	0	0.292	0.467	1.000
88	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(1), ELK1(3), IL6(1), IL6ST(2), JAK2(3), JAK3(1), MAPK3(1), PTPN11(6), RAF1(1), SHC1(1), SOS1(1), SRF(2), STAT3(1)	7716870	25	15	24	7	3	6	1	10	4	1	0.340	0.473	1.000
89	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), CAT(2), GH1(1), GHR(2), IGF1R(3), SHC1(1), SOD2(1)	3081306	11	5	11	1	2	3	2	3	1	0	0.0833	0.474	1.000
90	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), IDI1(1), SQLE(1)	1369511	3	2	3	0	0	0	3	0	0	0	0.329	0.474	1.000
91	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(8), DAXX(2), PAX3(1), PML(3), RB1(4), SP100(3), TNFRSF1B(2)	5865203	23	9	23	4	5	2	2	9	5	0	0.194	0.482	1.000
92	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(2), E2F1(1), MDM2(2), POLR1A(4), POLR1B(2), RAC1(1), RB1(4), TBX2(1)	5061167	21	8	21	6	5	2	3	5	6	0	0.414	0.483	1.000
93	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(3), ST3GAL1(1), ST3GAL4(2)	2534693	6	5	6	2	2	2	0	1	1	0	0.578	0.484	1.000
94	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(3), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5)	3803994	12	5	12	3	3	1	0	5	2	1	0.506	0.489	1.000
95	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22RA1(1), JAK2(3), JAK3(1), STAT1(2), STAT3(1), STAT5B(2), TYK2(5)	5950948	15	7	15	4	3	0	0	9	2	1	0.564	0.492	1.000
96	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(2), LPO(5), MPO(2), MTHFR(6), SHMT1(1), TPO(4)	3749710	23	9	23	5	9	7	1	5	1	0	0.0634	0.498	1.000
97	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(3), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), GCDH(1), ITGB1BP3(1), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3)	8373193	30	10	28	7	8	6	2	7	7	0	0.291	0.507	1.000
98	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(2), PLCB2(2)	3594474	11	9	11	4	4	3	0	2	2	0	0.557	0.507	1.000
99	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), JAK2(3), TYK2(5)	3393741	9	5	9	2	3	0	1	3	2	0	0.486	0.509	1.000
100	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), JAK2(3), TYK2(5)	3393741	9	5	9	2	3	0	1	3	2	0	0.486	0.509	1.000
101	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(2), EPX(2), LPO(5), MPO(2), PRDX1(1), SHMT1(1), TPO(4)	3812704	19	8	19	5	8	7	0	3	1	0	0.104	0.514	1.000
102	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(1), GLUD1(3), OAT(1)	1781758	7	4	7	3	1	1	0	4	1	0	0.766	0.514	1.000
103	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(2), PRKAA1(3), PRKAA2(2), ULK2(5)	6816390	25	8	25	2	5	3	5	8	4	0	0.0156	0.518	1.000
104	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), PLCG1(6), PRKCA(3), SHC1(1), SOS1(1)	3807108	12	8	11	3	3	2	2	2	2	1	0.431	0.519	1.000
105	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1)	1253934	2	2	2	0	0	0	0	1	1	0	0.516	0.523	1.000
106	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(1)	3468022	8	6	8	2	2	1	2	1	2	0	0.466	0.523	1.000
107	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ABAT(1), ADSL(3), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), ASS1(1), CAD(4), CRAT(1), DARS2(2), GAD1(2), GAD2(1), GOT1(2), NARS2(1), PC(1), PDHA1(2), PDHA2(4)	12223071	35	16	35	4	11	9	2	8	5	0	0.00575	0.524	1.000
108	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(2), SHMT1(1)	1779297	3	3	3	1	1	1	1	0	0	0	0.568	0.526	1.000
109	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(2), AGTR2(1), KNG1(1), NOS3(5), REN(1)	3203948	12	7	12	4	6	1	1	2	2	0	0.581	0.529	1.000
110	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	587607	2	2	2	0	2	0	0	0	0	0	0.524	0.532	1.000
111	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(2), ENPP1(1), ENPP3(2), G6PC(4), GAA(5), GANAB(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), MGAM(4), PYGB(1), PYGL(3), PYGM(1), SI(6), UCHL3(1), UGDH(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(2)	18403976	63	32	63	14	20	11	10	15	7	0	0.0283	0.536	1.000
112	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CHEK1(3), WEE1(1)	2220504	5	3	5	3	1	1	1	0	2	0	0.951	0.536	1.000
113	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(2)	967753	3	2	3	1	0	1	1	1	0	0	0.687	0.537	1.000
114	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2)	1546595	4	4	4	2	2	0	0	1	1	0	0.865	0.538	1.000
115	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), F2(2), F5(7), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), PROS1(1), SERPING1(1)	14360896	48	23	48	11	12	12	9	8	6	1	0.0483	0.539	1.000
116	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(1), MST1(4), MST1R(1)	2117527	6	3	6	2	1	2	0	3	0	0	0.555	0.542	1.000
117	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), DAXX(2), DDIT3(1), ELK1(3), MAP3K1(2), MAP3K5(2), MAP3K9(2), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), PLA2G4A(4), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1)	11825811	37	19	36	7	9	6	7	12	2	1	0.0773	0.545	1.000
118	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	369191	1	1	1	1	0	1	0	0	0	0	0.899	0.549	1.000
119	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(8), EP300(3), NCOA3(2), PRKAR1A(1), RXRA(1)	6675219	16	8	16	4	3	3	0	7	3	0	0.437	0.550	1.000
120	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	C1GALT1(1), GALNT1(1), GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GCNT4(2), OGT(6), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	10432366	36	15	36	9	10	9	1	12	4	0	0.223	0.556	1.000
121	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(1), UGP2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	8822548	29	16	29	8	7	2	8	11	1	0	0.287	0.557	1.000
122	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GAPDHS(1), GCK(1), GOT1(2), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PFKL(3), PGAM1(1), PGAM2(1), PKLR(1), TNFAIP1(2), TPI1(1)	13733944	44	19	44	3	17	14	3	8	2	0	2.32e-05	0.558	1.000
123	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PFKL(3), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2), TKTL2(1)	7844683	24	12	24	7	13	7	0	3	1	0	0.124	0.559	1.000
124	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(7), F7(2), FGA(4), FGB(1), PROS1(1)	5294363	17	12	17	5	6	2	4	4	1	0	0.382	0.562	1.000
125	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PDXK(1)	1568290	4	2	4	2	0	2	0	2	0	0	0.818	0.565	1.000
126	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK2(3), STAT1(2)	2647755	6	3	6	3	1	0	0	2	2	1	0.842	0.566	1.000
127	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(2)	1721526	3	3	3	0	0	0	0	3	0	0	0.585	0.580	1.000
128	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(1), IGF1R(3), POLR2A(3), PPP2CA(3), PRKCA(3), RB1(4), TEP1(7), TERF1(1), XRCC5(1)	7984539	26	11	26	4	8	2	5	6	4	1	0.0576	0.583	1.000
129	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), PAK1(2), PDGFRA(8), RAC1(1), WASL(1)	3113462	16	9	15	6	0	6	1	5	4	0	0.692	0.587	1.000
130	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), CCL5(1), CSK(1), F11R(1), GIT1(1), JAM2(3), JAM3(2), MAP3K14(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(1), MAPK9(1), MET(6), NFKB1(1), NFKB2(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(6), PTPN11(6), PTPRZ1(7), RAC1(1), RELA(1), TCIRG1(1), TJP1(4)	21858308	72	31	70	17	21	13	9	15	13	1	0.0443	0.588	1.000
131	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3)	5342140	20	6	18	2	5	3	1	5	6	0	0.126	0.592	1.000
132	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PRF1(1)	2826621	7	5	7	3	4	3	0	0	0	0	0.492	0.593	1.000
133	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), SP3(2)	6760537	24	11	23	6	9	3	3	5	3	1	0.234	0.593	1.000
134	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(2), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(3), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(1), SYK(1), VAV1(4), VAV2(1), VAV3(2)	10357979	32	13	32	8	6	8	2	12	3	1	0.174	0.594	1.000
135	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(3), PANK2(1), PANK4(3), VNN1(1)	5579072	16	9	16	3	3	3	0	7	3	0	0.370	0.600	1.000
136	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GLS(1), GLUD1(3), GLUL(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1)	10711068	32	13	32	7	8	6	3	10	5	0	0.144	0.604	1.000
137	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(3), PDHA1(2), PDHA2(4)	3246509	10	5	10	3	2	2	2	2	2	0	0.538	0.608	1.000
138	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), NAGLU(3), SPAM1(1)	6624276	20	9	20	5	7	1	4	4	4	0	0.392	0.610	1.000
139	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1)	15792495	56	24	56	13	20	12	6	14	4	0	0.0259	0.611	1.000
140	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1)	15792495	56	24	56	13	20	12	6	14	4	0	0.0259	0.611	1.000
141	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(1), BTK(1), FYN(1), GAB2(1), INPP5D(2), KRAS(1), LAT(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PRKCA(3), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4), VAV2(1), VAV3(2)	22092035	74	33	73	18	23	16	11	15	7	2	0.0311	0.611	1.000
142	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(10), ACADL(1), ACADM(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ECHS1(2), EHHADH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1)	10696990	39	14	38	10	11	12	2	10	4	0	0.160	0.614	1.000
143	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RXRA(1)	1875389	7	6	7	4	1	1	1	4	0	0	0.814	0.621	1.000
144	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD4(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), STAT4(2), TYK2(5)	4758226	16	6	16	5	6	2	1	5	2	0	0.483	0.627	1.000
145	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(2), GALNT4(1), GALNT6(2), GALNT8(1), GALNT9(2), ST3GAL1(1), ST3GAL4(2), WBSCR17(4)	4667958	16	7	16	4	7	4	0	4	1	0	0.260	0.631	1.000
146	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(10), ACACB(5), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ALDH7A1(2), ECHS1(2), EHHADH(1), HIBCH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1)	12828543	49	18	48	13	16	13	4	11	5	0	0.116	0.634	1.000
147	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(3), CR2(3), HLA-DRA(2), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4)	4910342	17	11	17	5	7	5	0	4	1	0	0.320	0.639	1.000
148	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(1), ELK1(3), IGF1R(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2)	6790776	26	17	25	8	4	7	2	7	5	1	0.348	0.641	1.000
149	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(1), CCNH(2), CDC25A(1), SHH(1), XPO1(1)	2805205	6	4	6	3	1	5	0	0	0	0	0.659	0.656	1.000
150	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(1), GGH(1), SPR(1)	2100770	3	3	3	1	1	1	0	0	1	0	0.756	0.657	1.000
151	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(3), PRKCA(3)	2907243	6	3	6	0	1	1	2	1	0	1	0.118	0.662	1.000
152	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(2), EGF(3), HGS(3), TF(1), TFRC(1)	3288427	10	6	10	2	4	2	1	2	1	0	0.303	0.666	1.000
153	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(4), ATR(4), CHEK1(3), CHEK2(3), YWHAH(1)	4908299	15	5	15	4	4	4	1	3	3	0	0.594	0.668	1.000
154	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), GFPT1(1), GNE(1), GNPDA1(2), HEXA(1), HK1(3), HK2(2), HK3(1), RENBP(1)	5484746	14	7	14	4	3	4	3	3	1	0	0.389	0.674	1.000
155	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(1)	2114719	3	3	3	0	0	1	0	2	0	0	0.357	0.674	1.000
156	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(1)	2114719	3	3	3	0	0	1	0	2	0	0	0.357	0.674	1.000
157	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(2), PTPRC(4), ZAP70(3)	2921662	12	6	12	2	4	3	0	5	0	0	0.232	0.680	1.000
158	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), C9orf95(1), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT3(1), NNMT(1), NNT(3), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1)	6948691	20	8	20	3	1	8	4	5	2	0	0.0776	0.680	1.000
159	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), GAD1(2), GAD2(1), GOT1(2), PC(1)	8417973	24	10	24	2	8	6	0	7	3	0	0.0115	0.680	1.000
160	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CFLAR(1), DAXX(2), DFFA(1), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(8), PTPN13(1), RB1(4), SPTAN1(2)	13098788	32	14	32	6	6	6	4	8	7	1	0.127	0.685	1.000
161	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(3), EPRS(2), GUSB(2), HCCS(3), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2), UROS(1)	8848315	26	14	26	5	7	1	8	9	1	0	0.110	0.686	1.000
162	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(3), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(4), G6PC2(1), GALM(1), GAPDHS(1), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PFKL(3), PGAM1(1), PGAM2(1), PKLR(1), TPI1(1)	18811322	69	28	69	12	26	13	7	18	5	0	0.00133	0.687	1.000
163	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(2)	1050958	3	3	3	2	1	0	0	1	1	0	0.802	0.688	1.000
164	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD4(1)	1039182	3	2	3	2	1	1	0	1	0	0	0.811	0.688	1.000
165	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(1), CDC25A(1), CSK(1), PRKCA(3), PTPRA(4)	2978712	10	3	10	3	3	3	2	1	0	1	0.403	0.689	1.000
166	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCA(1), SNCAIP(1)	2080004	4	3	4	2	3	0	0	1	0	0	0.719	0.693	1.000
167	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), PPP2CA(3), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1)	4936244	15	7	15	4	4	0	0	8	3	0	0.608	0.698	1.000
168	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CFL1(1), E2F1(1), MDM2(2), PRB1(2)	2445355	13	8	13	5	3	2	3	3	2	0	0.587	0.703	1.000
169	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), RECK(2), TIMP3(2), TIMP4(1)	2432250	6	3	6	1	1	2	2	0	1	0	0.336	0.705	1.000
170	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(2)	1213959	3	2	3	0	1	0	0	2	0	0	0.423	0.709	1.000
171	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(2), ACO2(2), FH(1)	2348396	5	3	5	0	3	1	0	1	0	0	0.163	0.713	1.000
172	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(2), CES1(1), CES7(1), ESCO2(2), LIPA(2), MYST3(1), MYST4(9), PLA1A(2), PNPLA3(1), SH3GLB1(3)	8182583	24	8	23	6	3	4	3	6	8	0	0.435	0.714	1.000
173	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNGR2(1), JAK2(3), NFKB1(1), RB1(4), RELA(1), TNFRSF1B(2), WT1(1)	5600880	16	6	16	8	4	1	1	4	6	0	0.874	0.714	1.000
174	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EARS2(1), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GFPT2(3), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), GNPNAT1(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1)	12751310	40	17	40	10	8	8	4	13	7	0	0.189	0.725	1.000
175	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKAR1A(1), PTPRC(4), ZAP70(3)	7399880	25	12	25	6	7	4	0	11	3	0	0.323	0.725	1.000
176	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKAR1A(1), PTPRC(4), ZAP70(3)	7399880	25	12	25	6	7	4	0	11	3	0	0.323	0.725	1.000
177	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), LPA(5), PLAT(1), PLAU(1), PLG(3), SERPINE1(1), SERPINF2(1), VWF(5)	11400787	46	17	46	10	13	7	6	14	6	0	0.0604	0.728	1.000
178	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	1260201	1	1	1	1	0	1	0	0	0	0	0.875	0.728	1.000
179	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB3A(1), RAB9A(1)	1367216	3	2	3	0	2	1	0	0	0	0	0.267	0.729	1.000
180	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(2), ARSE(2), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(1), UGCG(2)	7818589	29	12	28	5	10	3	1	10	5	0	0.114	0.733	1.000
181	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), PRKAR1A(1)	2112413	5	5	5	2	1	0	0	2	2	0	0.797	0.736	1.000
182	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(1), NFS1(3), THTPA(2)	2074775	9	2	9	2	1	3	0	4	1	0	0.514	0.745	1.000
183	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(3), CREB1(1), CREB3(1), MAPK1(1), RAF1(1), SNX13(1)	3606975	9	4	9	2	1	1	2	2	3	0	0.412	0.748	1.000
184	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPP(1), ALPP(1), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), PON1(2), PON3(1)	5804831	10	7	9	1	5	0	0	1	4	0	0.139	0.748	1.000
185	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), PRB1(2)	2882957	11	7	11	3	3	1	4	2	1	0	0.372	0.753	1.000
186	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(4)	12685108	39	18	38	10	11	7	5	11	4	1	0.170	0.754	1.000
187	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(1), GUSB(2), HEXA(1), IDS(1), LCT(5), NAGLU(3)	4648962	13	6	13	4	6	1	2	2	2	0	0.517	0.768	1.000
188	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(3), DDC(1), GAD1(2), GAD2(1), HDC(2), PAH(1), TH(1), TPH1(2)	4641992	16	7	16	6	7	5	0	2	2	0	0.417	0.769	1.000
189	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C3AR1(2), C4BPA(2), C4BPB(1), C5(4), C6(2), C7(4), C8A(1), C8B(3), CD46(2), CD55(1), CFD(1), CFH(6), CPB2(1), CR1(3), CR2(3), F13A1(2), F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), KNG1(1), MBL2(2), PLAT(1), PLAU(1), PLG(3), PROS1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), VWF(5)	29221147	110	44	110	29	31	19	14	32	14	0	0.0308	0.771	1.000
190	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(3), LPL(2), NCOA1(1), PPARG(1), RXRA(1)	5965841	16	8	16	5	3	3	0	9	1	0	0.592	0.774	1.000
191	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1)	2250630	8	3	8	3	0	0	1	4	3	0	0.791	0.775	1.000
192	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3D(1), ELK1(3), FYN(1), LAT(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(1), VAV1(4), ZAP70(3)	14225955	49	19	48	13	19	8	3	11	6	2	0.130	0.775	1.000
193	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(6), PRKCA(3)	2174871	12	8	11	7	5	2	2	1	1	1	0.838	0.778	1.000
194	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(2), G6PC(4), GAA(5), GANAB(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4)	10533733	32	15	32	9	19	4	2	6	1	0	0.189	0.779	1.000
195	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(4)	2721745	5	3	5	0	2	1	1	1	0	0	0.168	0.780	1.000
196	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), CRADD(1), DFFA(1), LMNA(2), LMNB2(2), MADD(1), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(8), RB1(4), RIPK1(1), SPTAN1(2), TRADD(1)	12472362	29	16	29	6	8	4	4	5	7	1	0.162	0.780	1.000
197	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(1), KDR(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NOS3(5), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(1), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2)	22026601	85	36	84	23	30	14	15	15	9	2	0.0446	0.780	1.000
198	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), STAT1(2), TYK2(5)	3500853	9	4	9	3	2	0	1	4	1	1	0.670	0.781	1.000
199	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(3), EPOR(1), JAK2(3), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1), STAT5B(2)	6938242	21	11	20	6	3	6	1	6	4	1	0.325	0.784	1.000
200	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(1)	532411	3	1	3	0	0	3	0	0	0	0	0.291	0.784	1.000
201	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), GH1(1), GHR(2), NFKB1(1), PPP2CA(3), RELA(1), YWHAH(1)	3325546	10	4	10	4	3	1	1	4	1	0	0.763	0.785	1.000
202	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAX(1), BCL2L11(1), CASP8AP2(2), CES1(1)	3483797	6	3	6	0	1	2	0	1	2	0	0.181	0.786	1.000
203	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), AXIN1(1), BTRC(1), CCND1(1), CREBBP(8), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTBP1(3), FZD1(1), NLK(1), PPP2CA(3), WIF1(2)	9483112	27	9	27	5	6	4	2	11	4	0	0.127	0.788	1.000
204	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(2), OXCT1(1)	2317044	7	2	7	0	1	3	0	3	0	0	0.118	0.789	1.000
205	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1)	5333208	15	10	15	5	4	2	2	5	2	0	0.666	0.790	1.000
206	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HSD17B4(2), MECR(1), PPT2(2)	2736878	9	5	9	4	3	2	0	2	2	0	0.783	0.791	1.000
207	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CEL(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GLA(1), GLB1(1), LCT(5), LIPC(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(3), PPAP2A(2), PPAP2C(1)	15575151	56	20	56	16	21	6	9	15	5	0	0.124	0.792	1.000
208	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(3)	995205	3	1	3	2	0	1	0	1	1	0	0.838	0.792	1.000
209	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(3), PLCE1(6), PRKAR1A(1), RAP2B(1)	4746756	13	8	13	4	4	3	1	2	3	0	0.502	0.794	1.000
210	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(9), C5(4), C6(2), C7(4), ICAM1(2), IL6(1), ITGA4(2), ITGAL(2), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(1)	8014280	33	18	33	11	9	6	5	8	5	0	0.325	0.795	1.000
211	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(3), CBS(3), CTH(1), MUT(1)	1585906	8	2	8	0	2	5	0	1	0	0	0.0468	0.796	1.000
212	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(2), HK3(1), ISYNA1(2), TGDS(1)	3774191	10	5	10	2	3	4	2	1	0	0	0.183	0.799	1.000
213	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), OAT(1), ODC1(2), SMS(1)	5667340	18	6	18	5	3	4	0	6	5	0	0.476	0.799	1.000
214	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NQO2(1), SQLE(1)	3572052	9	3	9	4	3	1	3	1	1	0	0.586	0.802	1.000
215	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(3), GTF2F1(2), GTF2H1(1), GTF2IRD1(2), TAF1(7), TAF1L(1), TAF2(1), TAF4(3), TAF4B(3), TAF5L(2), TAF6L(1), TAF7L(1), TAF9(2), TAF9B(1), TBPL1(1)	11633193	31	12	31	5	6	9	3	10	3	0	0.0446	0.802	1.000
216	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AGK(1), AGPAT3(1), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CEL(1), DAK(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK2(3), GLA(1), GLB1(1), GPAM(1), LCT(5), LIPA(2), LIPC(1), LIPG(2), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(2), PPAP2C(1)	18967004	68	23	68	17	25	6	12	19	6	0	0.0522	0.803	1.000
217	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(1), GGT1(2), MARS(4), MARS2(1), SCLY(1)	4000845	12	4	12	1	3	5	1	3	0	0	0.0459	0.803	1.000
218	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	NFKB1(1), NOX1(1), RELA(1), XDH(7)	3208676	10	3	10	4	2	2	0	5	1	0	0.673	0.806	1.000
219	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(9), C5(4), C6(2), C7(4), C8A(1)	4056869	20	10	20	7	5	2	3	5	5	0	0.487	0.808	1.000
220	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(3), ESR1(1), MAPK1(1), MAPK3(1), PELP1(1)	4765601	15	4	15	4	5	2	0	6	1	1	0.443	0.809	1.000
221	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1)	1528404	1	1	1	0	0	0	0	0	1	0	0.719	0.810	1.000
222	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1), RB1(4), RELA(1)	5055638	15	6	15	6	6	2	1	1	4	1	0.700	0.810	1.000
223	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1), SYK(1), VAV1(4)	12343198	40	16	39	10	13	7	4	9	5	2	0.117	0.818	1.000
224	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK2(3), PTPRU(2), REG1A(1), STAT1(2)	3694252	9	5	9	4	2	1	0	2	3	1	0.690	0.820	1.000
225	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(1), ELK1(3), MAPK3(1), MAPK8(1), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1)	4945505	16	9	15	5	2	6	1	3	3	1	0.377	0.822	1.000
226	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST13(1), SULT2A1(2), SULT2B1(1), SUOX(1)	2958947	7	3	7	3	0	1	0	5	1	0	0.814	0.827	1.000
227	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(1)	2628282	7	2	7	1	0	2	1	4	0	0	0.365	0.828	1.000
228	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(1), ABCB4(4), ABCC1(4), ABCC3(6)	4633699	18	6	18	4	4	2	3	7	2	0	0.263	0.834	1.000
229	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CD4(1), HLA-DRA(2), IL1B(1), IL5RA(1), IL6(1)	1726053	7	3	7	2	0	0	0	7	0	0	0.710	0.835	1.000
230	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), HMGB2(1), TOP2A(4), TOP2B(1)	2841465	7	2	7	3	3	1	2	0	1	0	0.682	0.841	1.000
231	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(1), ITPR1(2), ITPR2(11), ITPR3(6), PDK1(2), PHF11(1), PITX2(3), PLCG2(6), PPP1R13B(1), PREX1(5), PTPRC(4), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(1), SYK(1), TEC(1), VAV1(4)	16883485	62	24	62	16	20	11	9	21	1	0	0.0934	0.843	1.000
232	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), FSHR(2), GNAS(3), XPO1(1)	3073342	8	7	8	3	1	1	1	3	2	0	0.771	0.846	1.000
233	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	RIPK1(1), TNFRSF1B(2), TRADD(1)	2705368	4	3	4	2	2	0	0	0	2	0	0.775	0.848	1.000
234	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHSY1(1), DSE(1), XYLT1(1), XYLT2(1)	4499934	10	6	10	2	3	1	0	6	0	0	0.349	0.849	1.000
235	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(2), HK3(1), TGDS(1)	3307949	8	4	8	2	3	3	2	0	0	0	0.296	0.854	1.000
236	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(5), PYGL(3), PYGM(1), TPI1(1), TREH(1)	4334642	14	6	14	5	4	4	2	2	2	0	0.467	0.855	1.000
237	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(2), DAG1(1), DLG4(3), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RYR1(10)	14787823	47	17	47	11	14	9	9	12	3	0	0.0756	0.856	1.000
238	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP4B(2), INPP5B(2), INPPL1(4), IPMK(1), ISYNA1(2), ITGB1BP3(1), ITPK1(2), MINPP1(1), OCRL(4), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), SYNJ1(4), SYNJ2(5)	23046686	79	31	78	19	20	16	8	24	11	0	0.0634	0.856	1.000
239	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(1), CPO(1), HBA2(1), UROS(1)	2546634	6	2	6	1	3	0	1	2	0	0	0.392	0.857	1.000
240	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AGT(2), AKT1(1), CALR(2), CAMK1G(1), CAMK4(1), CREBBP(8), CSNK1A1(2), F2(2), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(8), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RAF1(1), RPS6KB1(1)	15166254	45	18	45	13	16	8	2	14	4	1	0.159	0.860	1.000
241	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(1), RALBP1(1), RALGDS(2), RELA(1)	4933051	14	6	14	7	3	2	1	3	4	1	0.794	0.862	1.000
242	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(2), TH(1), TPH1(2)	1950402	7	3	7	2	4	2	0	1	0	0	0.349	0.864	1.000
243	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), IL3RA(2), JAK2(3), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2)	5709695	12	6	12	4	2	0	0	5	4	1	0.655	0.865	1.000
244	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF4E(1), IGF1R(3), INPPL1(4), PPP2CA(3), RPS6KB1(1)	4876109	13	4	13	4	2	3	2	4	2	0	0.446	0.865	1.000
245	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(1), GNAS(3), PRKAR1A(1), SLC9A3R1(1)	4203884	8	7	8	3	3	1	0	2	2	0	0.681	0.866	1.000
246	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	2651777	6	2	6	3	1	3	0	0	1	1	0.520	0.870	1.000
247	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), CFL1(1), FLNA(8), FLNC(7), FSCN1(2), FSCN2(1), GDI1(3), LIMK1(2), MYH2(8), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), ROCK1(2), ROCK2(2), RPS4X(2), WASF1(1), WASL(1)	15462312	57	19	57	15	20	9	7	16	5	0	0.0657	0.871	1.000
248	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), MAPK1(1), MAPK8(1), PRKCA(3)	2854422	6	2	6	1	1	2	1	0	1	1	0.221	0.871	1.000
249	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(2), FGA(4), FGB(1), PLAT(1), PLAU(1), PLG(3), SERPINE1(1)	4331976	16	8	16	5	8	3	1	2	2	0	0.334	0.872	1.000
250	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(5)	4038715	11	6	11	4	2	1	1	3	3	1	0.643	0.875	1.000
251	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CYCS(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), SMPD1(1), TRADD(1)	6630949	15	8	15	7	4	3	0	3	4	1	0.749	0.879	1.000
252	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(3), PGM2(5), SORD(1), TPI1(1), TSTA3(1)	12028493	36	14	36	8	16	9	2	5	4	0	0.0504	0.879	1.000
253	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), IL6(1), IL9(1)	1925035	3	2	3	1	0	0	0	3	0	0	0.803	0.880	1.000
254	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAX(1), BIRC2(1), CYCS(2), DFFA(1), DIABLO(1)	4335087	7	3	7	1	1	2	0	3	1	0	0.323	0.880	1.000
255	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(4), PPP2CA(3), PRKAG1(1)	5871612	13	5	13	3	2	2	1	6	2	0	0.416	0.881	1.000
256	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD4(1), IL6(1), KITLG(2)	1997771	5	2	5	1	0	1	1	3	0	0	0.522	0.882	1.000
257	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(1), FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1)	2686257	10	3	10	3	5	1	1	2	1	0	0.548	0.883	1.000
258	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), G6PC(4), G6PC2(1), GAA(5), GANC(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4), PFKL(3), UGP2(1)	12492901	37	15	37	10	21	4	2	8	2	0	0.167	0.884	1.000
259	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(2), ARSE(2), B4GALT6(1), DEGS1(2), DEGS2(1), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SPTLC1(2), SPTLC2(1), UGCG(2)	11526070	39	14	38	7	13	4	2	15	5	0	0.0623	0.884	1.000
260	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(3), CPEB1(3), ERBB2(1), ERBB4(3), ETS1(3), ETV6(2), ETV7(1), FMN2(2), KRAS(1), MAPK1(1), MAPK3(1), NOTCH2(9), NOTCH3(4), NOTCH4(8), PIWIL2(3), PIWIL3(1), RAF1(1), SOS1(1), SOS2(4), SPIRE1(1), SPIRE2(2)	14744718	55	24	55	14	15	12	10	11	5	2	0.124	0.895	1.000
261	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1), MBL2(2)	6867942	31	14	31	10	8	3	4	10	6	0	0.427	0.898	1.000
262	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CYCS(2), PRF1(1)	4157413	7	4	7	3	1	4	0	2	0	0	0.653	0.899	1.000
263	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(2), ACO2(2), FH(1), IDH3B(1), PC(1), PCK1(3), SUCLG2(1)	6124669	11	6	11	2	5	4	0	2	0	0	0.157	0.900	1.000
264	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCR(1), CRKL(1), JAK2(3), MAP3K1(2), MAPK3(1), MAPK8(1), RAF1(1), SOS1(1), STAT1(2), STAT5B(2)	7852936	16	6	16	4	4	3	0	4	3	2	0.259	0.900	1.000
265	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASDHPPT(1)	2251503	3	2	3	0	0	0	1	1	1	0	0.384	0.901	1.000
266	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(2), EHHADH(1)	1560559	5	2	5	3	2	1	1	0	1	0	0.762	0.906	1.000
267	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), JAK2(3), JAK3(1), PIAS3(1), PTPRU(2), REG1A(1), STAT3(1)	4929745	11	8	11	4	2	1	0	5	3	0	0.658	0.907	1.000
268	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), BRAF(3), DAG1(1), EPHB2(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT3(1)	18060242	50	17	50	10	13	6	11	16	4	0	0.0445	0.912	1.000
269	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(1), APC(2), AR(2), BRAF(3), DAG1(1), GNA11(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(4), PIK3CD(1), PITX2(3), PTX3(1), RAF1(1)	15190995	45	15	45	12	11	6	11	13	4	0	0.178	0.914	1.000
270	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(2), ALG6(3), DAD1(1), DHDDS(2), DPAGT1(1), DPM1(2), FUT8(3), GANAB(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(1), RPN2(1), ST6GAL1(1), STT3B(1)	13670920	44	17	44	11	9	10	7	7	11	0	0.188	0.915	1.000
271	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), BCAR1(1), CDKN1B(1), ITGB1(2), MAPK1(1), MAPK3(1), PTK2(1), SHC1(1), SOS1(1)	4753664	10	3	10	4	3	1	1	2	2	1	0.667	0.916	1.000
272	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), CES1(1), CES2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2)	7380990	14	7	14	4	4	2	3	4	1	0	0.354	0.917	1.000
273	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), IARS2(2), ILVBL(3), LARS(3), PDHA1(2), PDHA2(4), VARS(3), VARS2(1)	6008816	19	7	19	5	4	4	2	6	3	0	0.431	0.918	1.000
274	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TPI1(1)	5826742	12	5	12	2	5	2	1	3	1	0	0.213	0.919	1.000
275	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4872657	7	3	7	2	2	4	0	0	0	1	0.421	0.922	1.000
276	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4872657	7	3	7	2	2	4	0	0	0	1	0.421	0.922	1.000
277	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4872657	7	3	7	2	2	4	0	0	0	1	0.421	0.922	1.000
278	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(3), MAP3K1(2), NCOR2(3), RXRA(1)	4728176	9	6	9	4	4	2	0	2	1	0	0.692	0.922	1.000
279	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(2), CASP1(1), INSR(3), MAGI1(2), MAGI2(4), RERE(5), WWP1(3)	7741494	23	9	23	6	10	6	1	4	2	0	0.228	0.923	1.000
280	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(2), CRY1(3), EIF4G2(1), ETV6(2), HERPUD1(1), HSPA8(1), IDI1(1), NCKAP1(2), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), TUBB3(3), UGP2(1), ZFR(1)	11801856	36	13	36	8	5	10	6	11	4	0	0.152	0.924	1.000
281	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(2), AGTR2(1), EDNRB(1), EGF(3), NFKB1(1), PLCG1(6), PRKCA(3), RELA(1)	5776517	18	9	17	7	6	3	2	5	1	1	0.611	0.924	1.000
282	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CCNB1(1), GNAI1(1), GNAS(3), MAPK1(1), MAPK3(1), MYT1(3), PRKAR1A(1), RPS6KA1(2)	6610830	14	10	14	8	1	2	0	4	6	1	0.893	0.925	1.000
283	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(4), ATR(4), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), RB1(4), SKP2(2), TGFB2(2), TGFB3(1)	9488294	30	10	30	6	8	4	5	7	6	0	0.122	0.925	1.000
284	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), CISH(1), IARS(1), IL13RA1(1), INPP5D(2), JAK2(3), JAK3(1), PI3(1), PPP1R13B(1), RPS6KB1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3), TYK2(5)	11223147	28	12	28	4	8	2	3	10	5	0	0.0792	0.925	1.000
285	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT3(1), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(1), MYST3(1), MYST4(9), PCYT1B(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(4), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(1), SH3GLB1(3)	21093852	61	20	60	15	17	14	6	13	11	0	0.0915	0.925	1.000
286	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(3), IRS1(2), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), YWHAH(1)	4908217	12	7	12	4	1	4	1	1	4	1	0.468	0.925	1.000
287	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	HSD11B1(1)	2234212	1	1	1	1	1	0	0	0	0	0	0.848	0.927	1.000
288	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(5), FYN(1), ITGA1(2), ITGB1(2), L1CAM(4), SELP(2)	5101359	16	5	16	6	5	3	2	6	0	0	0.564	0.927	1.000
289	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(1), CBR3(1), CYP4F3(4), EPX(2), GGT1(2), LPO(5), LTA4H(2), MPO(2), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TPO(4)	9016633	40	23	40	12	11	11	4	9	5	0	0.146	0.928	1.000
290	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CAPNS1(1), CAPNS2(1), EP300(3), HDAC2(4), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3)	7876165	24	8	24	8	7	3	3	5	5	1	0.565	0.930	1.000
291	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(1), AKT1(1), BAX(1), CSF2RB(1), IGF1R(3), IL3RA(2), KIT(3), KITLG(2), PRKAR1A(1), YWHAH(1)	5864869	16	8	16	5	2	2	2	5	5	0	0.478	0.930	1.000
292	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), GREB1(5), MTA3(2)	3526400	8	3	8	1	5	0	1	2	0	0	0.191	0.937	1.000
293	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGT(2), AGTR2(1), ANPEP(2), CMA1(2), CTSG(1), ENPEP(3), LNPEP(1), MME(2), REN(1), THOP1(3)	6846962	23	9	23	4	8	5	1	6	3	0	0.0807	0.937	1.000
294	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(4), ATR(4), BRCA1(1), BRCA2(4), CHEK1(3), CHEK2(3), FANCA(2), FANCC(1), FANCD2(2), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(2), RAD9A(1), TREX1(1)	14002862	37	11	37	8	9	10	4	9	5	0	0.175	0.940	1.000
295	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ECHS1(2), EHHADH(1)	3927954	15	8	15	7	7	3	1	1	3	0	0.586	0.942	1.000
296	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR2(1), CMA1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), REN(1)	8160096	23	9	23	8	6	9	1	3	3	1	0.474	0.942	1.000
297	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), FDXR(1), SHMT1(1)	5185119	8	3	8	2	3	4	0	0	0	1	0.341	0.942	1.000
298	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B2(1), HSD17B4(2)	2620268	3	3	3	3	1	0	0	1	1	0	0.964	0.943	1.000
299	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), LMNA(2), LMNB2(2), PRF1(1)	6235175	13	5	13	3	3	5	1	3	1	0	0.274	0.946	1.000
300	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1)	2626546	9	3	9	3	2	1	1	4	1	0	0.579	0.947	1.000
301	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(2), ACADM(1), ACADS(1), ACAT2(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), ALDH7A1(2), AOX1(3), BCKDHA(1), DBT(2), ECHS1(2), EHHADH(1), HIBADH(1), HIBCH(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2)	13900413	47	17	46	13	17	12	3	8	7	0	0.179	0.948	1.000
302	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1)	4360447	10	5	10	4	4	2	1	3	0	0	0.623	0.949	1.000
303	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), FCGR3A(1), IL1B(1), SPN(1), TGFB2(2), TNFRSF1B(2), TNFRSF8(1), TNFSF8(1)	4226202	13	5	13	4	5	3	1	2	2	0	0.349	0.949	1.000
304	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK2(3), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1), SOAT1(1)	4432484	11	8	11	7	2	1	0	5	3	0	0.937	0.952	1.000
305	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TKTL2(1), TPI1(1)	6514736	13	6	13	2	5	2	1	4	1	0	0.183	0.953	1.000
306	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(1), GOT1(2), PAH(1), TAT(1), YARS(1)	2814325	6	3	6	3	2	1	1	1	1	0	0.833	0.953	1.000
307	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1)	2488542	6	2	6	3	1	2	0	2	1	0	0.837	0.953	1.000
308	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(2), PRKCA(3), RELA(1)	2661481	7	4	7	5	2	0	1	3	0	1	0.919	0.955	1.000
309	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), FBP1(1), FBP2(2), FPGT(1), GCK(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), PFKFB1(3), PFKFB3(2), SORD(1), TPI1(1)	7737991	21	8	21	5	8	8	1	3	1	0	0.0740	0.955	1.000
310	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(8), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1)	10062593	38	21	36	12	8	10	3	7	7	3	0.343	0.957	1.000
311	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(3), CREBBP(8), EP300(3), MAPK3(1), SKIL(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2)	8290939	25	7	25	4	5	4	1	13	1	1	0.142	0.957	1.000
312	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKAG1(1)	3254985	6	2	6	1	1	0	0	4	1	0	0.487	0.958	1.000
313	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK3(1), PABPC1(4), PRKCA(3), RPS6KB1(1)	7611421	26	12	26	8	5	7	3	3	6	2	0.463	0.960	1.000
314	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGF(3), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SPRY1(1), SPRY4(1)	7205669	19	10	19	5	6	1	2	4	5	1	0.432	0.961	1.000
315	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), MBTPS1(1), MBTPS2(2), SCAP(1), SREBF1(4), SREBF2(1)	3873194	10	3	10	3	0	2	3	5	0	0	0.513	0.961	1.000
316	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(4), AOX1(3), DDC(1), ECH1(1), ESCO2(2), FAH(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), MYST3(1), MYST4(9), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), SH3GLB1(3), TAT(1), TH(1), TPO(4), TYR(4), TYRP1(2)	19208972	73	25	72	23	19	9	8	25	12	0	0.337	0.962	1.000
317	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(2), EIF4A2(1), EIF4B(1), EIF4E(1), EIF4G1(2), EIF4G2(1), EIF4G3(4), PPP2CA(3), RPS6KB1(1), TSC1(2), TSC2(2)	7442362	21	11	21	6	4	5	4	5	3	0	0.369	0.963	1.000
318	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGAP4(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(3), INPPL1(4), ITPR1(2), ITPR2(11), ITPR3(6), LIMK1(2), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDK1(2), PIK3CD(1), PIK3CG(4), PITX2(3), PPP1R13B(1), ROCK1(2), ROCK2(2), RPS4X(2), SAG(1), WASF1(1), WASL(1)	21172938	70	23	70	16	17	14	14	21	4	0	0.0367	0.963	1.000
319	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(1), ANXA1(2), GNAS(3), NFKB1(1), NOS3(5), NR3C1(2), RELA(1)	4552192	16	10	16	7	9	0	2	3	2	0	0.765	0.964	1.000
320	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNB1(1), CHRNG(1), MUSK(4), PTK2(1), YWHAH(1)	4050442	9	4	9	6	2	0	1	4	2	0	0.948	0.965	1.000
321	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(2), DHRS3(1), DHRS7(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1)	4855894	15	3	14	3	6	2	1	5	1	0	0.177	0.965	1.000
322	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ARAF(1), ATF4(1), BRAF(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(8), EP300(3), GRIA1(3), GRIA2(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), GRM1(5), GRM5(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), RAF1(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2)	32152389	94	37	94	26	24	11	12	32	13	2	0.121	0.966	1.000
323	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), MAPK3(1), POLR2A(3), PRKAR1A(1)	4157559	6	3	6	2	1	0	0	3	1	1	0.652	0.967	1.000
324	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP7A(5), ATP7B(2), COX7A1(1), COX7B(1), NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1), SHMT1(1), UQCRC1(2), UQCRH(2)	12345356	31	9	31	5	5	6	2	12	5	1	0.0607	0.967	1.000
325	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL12B(2), IL15(2), IL16(6), IL6(1), IL9(1)	3208098	13	8	13	5	1	0	3	6	3	0	0.817	0.968	1.000
326	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), MAPK8(1), PLCG1(6), PRKCA(3)	4449543	11	8	10	6	2	3	3	1	1	1	0.736	0.969	1.000
327	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), SEC22B(1), SNAP29(1), STX11(1), TSNARE1(4), USE1(1), VAMP4(1), VAMP7(1), VAMP8(1), VTI1A(1)	5397916	13	8	13	7	5	3	1	1	3	0	0.792	0.970	1.000
328	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), GLB1(1), HEXA(1), LCT(5), SLC33A1(2), ST3GAL1(1), ST6GALNAC3(2), ST8SIA5(2)	5326097	16	7	16	7	8	1	1	2	4	0	0.843	0.970	1.000
329	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL29(1), RPL32(1), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(1), RPS3(1)	7278842	16	5	16	2	7	1	3	3	2	0	0.196	0.972	1.000
330	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(3), CTH(1), GGT1(2), LCMT1(2), LCMT2(1), MARS(4), MARS2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SCLY(1)	8062953	23	5	23	4	5	7	2	8	1	0	0.0580	0.974	1.000
331	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUL(1), HAL(1)	6143797	15	9	15	6	2	5	1	4	3	0	0.660	0.975	1.000
332	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), DPAGT1(1), DPM1(2), FUT8(3), MAN1A1(2), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), RPN2(1), ST6GAL1(1)	6414678	20	8	20	6	4	5	3	3	5	0	0.391	0.976	1.000
333	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	ITGB1(2), KLRC1(1), KLRC2(1), LAT(1), MAPK3(1), PAK1(2), RAC1(1), SYK(1), VAV1(4)	4801019	14	5	14	7	2	2	3	2	4	1	0.774	0.977	1.000
334	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GBGT1(1), GLA(1), HEXA(1), ST3GAL1(1), ST3GAL4(2)	3268794	8	5	8	5	4	0	0	3	1	0	0.942	0.978	1.000
335	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(1), TPI1(1)	1265958	4	1	4	0	0	4	0	0	0	0	0.151	0.978	1.000
336	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACSL1(1), ACSL3(2), ACSL4(1), CPT1A(1), CPT2(1), DCI(1), EHHADH(1), SCP2(1), SLC25A20(1)	5438873	14	4	14	6	1	4	1	4	4	0	0.762	0.979	1.000
337	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(2), FUT6(2), ST3GAL6(2)	5202736	16	9	16	8	5	1	3	5	2	0	0.847	0.979	1.000
338	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1)	4547375	12	2	12	3	3	2	1	5	1	0	0.353	0.980	1.000
339	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CTH(1), GOT1(2), LDHB(1), SULT1B1(2), SULT1C2(3)	4054664	9	2	9	1	1	3	0	3	2	0	0.262	0.980	1.000
340	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), UBE2M(1)	3402436	2	2	2	7	0	0	1	0	1	0	1.000	0.981	1.000
341	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT2(2), GBGT1(1), GLA(1), HEXA(1), ST3GAL1(1)	3469496	7	3	7	6	4	0	0	2	1	0	0.979	0.981	1.000
342	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TOB1(1), TOB2(1)	3410239	10	4	10	2	3	3	1	3	0	0	0.254	0.982	1.000
343	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), AR(2), ESR1(1), ESR2(3), ESRRA(2), HNF4A(1), NPM1(2), NR1D1(1), NR1D2(1), NR1H2(1), NR1H3(4), NR1I2(1), NR2C2(1), NR2E1(1), NR2F2(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A1(1), PGR(2), PPARA(2), PPARG(1), ROR1(2), RXRA(1), RXRG(3), VDR(1)	13568567	40	12	39	10	14	7	6	9	4	0	0.0999	0.982	1.000
344	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(2), EHHADH(1), HSD17B4(2), SIRT7(1)	3827223	8	4	8	4	2	1	1	2	2	0	0.827	0.983	1.000
345	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1)	4134428	8	3	8	3	3	4	0	1	0	0	0.527	0.984	1.000
346	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), DFFA(1), PRF1(1), SCAP(1), SREBF1(4), SREBF2(1)	5901929	10	4	10	4	2	3	2	3	0	0	0.604	0.984	1.000
347	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(2), CRY1(3), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(4), PER2(3), PER3(1)	5516815	17	7	17	7	2	5	1	7	2	0	0.775	0.985	1.000
348	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAPK1(1), MAPK3(1), NFKB1(1), PLCB1(2), PRKCA(3), RAF1(1), RELA(1)	5012579	10	5	10	6	2	1	1	3	1	2	0.814	0.985	1.000
349	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CFL1(1), GNAS(3), LIMK1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(1), PIK3C2G(1), PLCB1(2), PRKCA(3), PTK2(1), RAF1(1), ROCK2(2)	8099725	21	13	21	9	3	2	2	8	4	2	0.814	0.985	1.000
350	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(4), MARS(4), MARS2(1), MTR(2)	5628364	23	7	23	9	6	5	0	9	2	1	0.514	0.985	1.000
351	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(3), MEF2A(2), MEF2B(1), PLCG1(6), RPS6KA1(2), SHC1(1)	4896152	19	9	18	7	3	6	1	6	2	1	0.515	0.985	1.000
352	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3), GPHN(1), NSF(2)	3862122	20	11	20	8	4	8	1	5	2	0	0.569	0.986	1.000
353	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(1), ATM(4), BAX(1), CYCS(2), PRKCA(3), PTK2(1), STAT1(2), TLN1(2)	8579711	17	6	17	5	4	2	1	7	1	2	0.440	0.986	1.000
354	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), ETV5(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), MAPK8(1), STAT4(2), TYK2(5)	6035563	17	7	17	8	6	3	2	4	2	0	0.782	0.986	1.000
355	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4)	3478779	11	8	11	5	5	5	0	1	0	0	0.540	0.987	1.000
356	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1)	4330441	8	3	8	3	3	4	0	1	0	0	0.520	0.987	1.000
357	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), SRD5A1(1), SULT2A1(2), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2B15(1), UGT2B4(2)	8831099	22	13	22	8	9	1	5	6	1	0	0.411	0.987	1.000
358	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(2), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1)	4100216	8	6	8	6	2	1	1	3	1	0	0.946	0.987	1.000
359	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(2), CA1(1), CA13(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), HAL(1)	6868588	17	10	17	8	2	6	1	5	3	0	0.776	0.988	1.000
360	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(2), ITGB2(1), PTPRC(4)	3648469	12	8	12	5	5	5	0	2	0	0	0.512	0.988	1.000
361	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPOR(1), JAK2(3), NFKB1(1), RELA(1), SOD2(1)	4093436	7	2	7	5	2	1	0	3	1	0	0.915	0.988	1.000
362	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), BRAF(3), CREB1(1), CREB3(1), CREBBP(8), CRKL(1), DAG1(1), EGR1(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(6), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), OPN1LW(1), PIK3C2G(1), PIK3CD(1), PTPN11(6), RPS6KA3(2), SHC1(1), TH(1)	15359879	52	23	51	17	13	8	6	19	5	1	0.325	0.989	1.000
363	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TLR4(1), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1)	16952308	52	19	52	16	18	6	12	12	3	1	0.189	0.989	1.000
364	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TLR4(1), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1)	16952308	52	19	52	16	18	6	12	12	3	1	0.189	0.989	1.000
365	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(1)	5173004	10	2	10	3	2	3	1	3	1	0	0.524	0.989	1.000
366	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10RB(1), IL6(1), STAT1(2), STAT3(1)	3932485	7	3	7	4	2	0	0	4	0	1	0.865	0.990	1.000
367	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(4), AKT1(1), ARAF(1), AREG(2), BRAF(3), BTC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBLB(1), CBLC(1), CDKN1B(1), CRKL(1), EGF(3), ELK1(3), ERBB2(1), ERBB3(2), ERBB4(3), KRAS(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), NRG1(2), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PRKCG(1), PTK2(1), RAF1(1), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), STAT5B(2)	31182805	91	35	90	20	29	14	10	22	14	2	0.0148	0.990	1.000
368	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAX(1), BFAR(1), BTK(1), CAD(4), CASP8AP2(2), CD7(1), CSNK1A1(2), DAXX(2), DFFA(1), DIABLO(1), EPHB2(1), FAF1(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(6), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TPX2(2), TUFM(1)	22326973	57	17	57	14	17	9	7	10	14	0	0.138	0.990	1.000
369	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), MAF(2), MAP2K3(2), NFATC1(1), NFATC2(4), PRKAR1A(1)	3920545	11	5	11	6	6	1	0	4	0	0	0.752	0.991	1.000
370	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(3), MAPK1(1), MAPK3(1), PRKAR1A(1), PRKCA(3), RAC1(1), RPS6KA1(2), SOS1(1)	8166301	20	8	20	5	5	3	1	4	5	2	0.332	0.991	1.000
371	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(5), FASN(1), MCAT(1), OXSM(1)	5112048	18	10	17	9	4	4	2	6	2	0	0.767	0.991	1.000
372	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(1), JAK2(3), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(3), PLCG1(6), PRKCA(3), RAF1(1), SHC1(1), SOS1(1), STAT1(2), STAT3(1)	13460447	37	14	36	10	11	7	3	7	6	3	0.170	0.992	1.000
373	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IRS1(2), JAK3(1), RPS6KB1(1), SHC1(1), STAT6(3)	4783581	9	5	9	4	2	2	0	4	1	0	0.725	0.992	1.000
374	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(1), ALPP(1), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2C9(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), PON1(2)	9430003	18	14	18	7	7	1	1	4	5	0	0.685	0.992	1.000
375	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGW(1), PIGZ(1)	7705650	19	4	19	4	9	3	3	4	0	0	0.110	0.992	1.000
376	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(1), DIAPH1(3), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), TLN1(2)	10839359	23	8	23	7	7	3	3	7	2	1	0.348	0.993	1.000
377	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), CHST1(1), CHST4(1), FUT8(3), ST3GAL1(1), ST3GAL4(2)	4015673	9	7	9	6	3	3	1	1	1	0	0.859	0.993	1.000
378	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD33(1), CD7(1), IFNB1(1), IL12B(2), TLR4(1), TLR7(3), TLR9(1)	6004076	12	6	11	9	2	2	2	4	2	0	0.964	0.994	1.000
379	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), AP2M1(1), BIN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5)	6936017	17	4	17	5	5	1	2	4	5	0	0.454	0.995	1.000
380	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), EPRS(2), FARS2(1), GARS(2), HARS(1), IARS(1), LARS(3), MARS(4), MARS2(1), QARS(1), RARS(2), WARS2(2), YARS(1)	10365161	22	6	22	6	5	6	1	8	2	0	0.421	0.995	1.000
381	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(2), COL4A4(3), COL4A5(3), COL4A6(5), SLC23A2(3), SLC2A1(1), SLC2A3(2)	8101504	20	8	20	8	6	7	1	2	3	1	0.522	0.995	1.000
382	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(2), PLCG1(6), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1)	9205214	25	12	24	8	7	7	2	2	5	2	0.293	0.995	1.000
383	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), CREB1(1), CREB3(1), DAG1(1), EPHB2(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1)	9239396	16	8	16	5	3	3	2	4	4	0	0.453	0.996	1.000
384	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(3), AKT1(1), ATM(4), BAX(1), CPB2(1), CSNK1A1(2), CSNK1D(1), IGFBP3(1), MAPK8(1), MDM2(2)	6438045	17	7	17	7	4	2	3	6	2	0	0.666	0.996	1.000
385	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	1678759	1	1	1	0	1	0	0	0	0	0	0.650	0.996	1.000
386	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(2), APOA1(1), CD36(3), CITED2(1), CREBBP(8), EHHADH(1), EP300(3), HSD17B4(2), LPL(2), MAPK1(1), MAPK3(1), ME1(1), NCOA1(1), NCOR1(8), NCOR2(3), NR1H3(4), NRIP1(1), PDGFA(1), PPARA(2), PRKAR1A(1), PRKCA(3), PTGS2(2), RB1(4), RELA(1), RXRA(1), STAT5B(2)	19210365	60	24	59	19	11	11	6	19	10	3	0.458	0.996	1.000
387	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(2), PRKCA(3), PTGS1(2), PTK2(1), RAF1(1), SYK(1)	7874948	23	14	23	9	2	3	5	9	2	2	0.682	0.997	1.000
388	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(3), GTF2F1(2), HDAC3(1), NCOA1(1), NCOA3(2), NCOR2(3), POLR2A(3), RXRA(1)	8060769	17	9	17	8	3	5	0	6	3	0	0.757	0.997	1.000
389	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCR(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), CSK(1), DAG1(1), FLOT1(1), FLOT2(1), INPP5D(2), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(4), PDK1(2), PIK3CD(1), PLCG2(6), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(4), RAF1(1), SHC1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4)	22663068	70	27	70	21	22	12	10	20	5	1	0.162	0.998	1.000
390	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2)	6594319	20	9	20	9	10	7	0	2	1	0	0.417	0.998	1.000
391	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDK2(1), CDKN1B(1), CDKN2A(2), CREB1(1), CREB3(1), ERBB4(3), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), MET(6), NOLC1(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPP1R13B(1), PREX1(5), PTK2(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SOS1(1), SOS2(4), TSC1(2), TSC2(2), YWHAH(1), YWHAQ(1), YWHAZ(1)	23987567	74	22	73	21	14	12	12	23	13	0	0.203	0.998	1.000
392	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(2), LDHB(1)	2213391	4	1	4	1	1	2	0	1	0	0	0.530	0.998	1.000
393	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(2), SDHC(1), UQCRC1(2)	2135329	5	2	5	2	0	1	1	3	0	0	0.730	0.998	1.000
394	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGEF6(3), BCAR1(1), BRAF(3), CDKN2A(2), DOCK1(1), EPHB2(1), FYN(1), GRB7(3), GRLF1(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PIK3CB(1), PKLR(1), PLCG1(6), PLCG2(6), PTK2(1), RAF1(1), RALA(1), ROCK1(2), ROCK2(2), SHC1(1), SOS1(1), SOS2(4), TLN1(2), TLN2(3), WAS(2)	38522009	107	37	106	23	31	15	14	32	15	0	0.0107	0.999	1.000
395	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATP6V0C(1), GART(3), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1)	5780564	18	3	18	8	5	6	2	3	1	1	0.586	0.999	1.000
396	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), BPNT1(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), RBL2(2), SHC1(1), SOS1(1)	5610173	11	4	11	7	1	3	0	5	1	1	0.897	0.999	1.000
397	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	MAP3K1(2), MAP3K5(2), MAP4K5(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF9(2)	6254463	10	6	10	5	4	2	2	1	1	0	0.753	0.999	1.000
398	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(1), ARHGEF1(1), F2(2), GNAI1(1), PLCB1(2), PRKCA(3), ROCK1(2)	7127924	12	7	12	8	3	2	2	2	2	1	0.873	0.999	1.000
399	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(2), ADCY9(3), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ERO1L(1), GNAS(3), PLCG1(6), PLCG2(6), PRKCA(3), SEC61A1(1)	11931972	35	19	34	11	17	7	3	4	3	1	0.280	0.999	1.000
400	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CMAS(1), GFPT1(1), GFPT2(3), GNE(1), GNPDA1(2), GNPNAT1(1), HEXA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), RENBP(1)	9281667	23	11	23	8	4	7	3	5	4	0	0.519	0.999	1.000
401	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(3), IL2RB(1), JAK3(1), MAPK3(1), MAPK8(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1)	7538375	14	9	14	6	1	4	1	5	2	1	0.626	0.999	1.000
402	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(2), TRAF3(1)	7256398	12	5	12	7	6	1	1	1	3	0	0.828	0.999	1.000
403	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP4(1), ARHGAP5(1), ARHGEF1(1), ARHGEF11(2), ARPC1B(1), ARPC3(1), BAIAP2(2), CFL1(1), DIAPH1(3), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(2), ROCK1(2), TLN1(2), VCL(1)	14647812	29	12	29	9	8	4	3	12	2	0	0.392	0.999	1.000
404	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(1), GCDH(1)	2519009	6	3	6	4	1	2	0	2	1	0	0.871	0.999	1.000
405	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), ELK1(3), MAP2K2(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(3), PTK2(1), RAC1(1), RAF1(1), SHC1(1), SOS1(1)	9968678	24	7	24	9	5	6	1	6	4	2	0.514	0.999	1.000
406	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(1), UROS(1)	2456723	4	1	4	1	2	0	0	2	0	0	0.640	0.999	1.000
407	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(2), ALOX15(1), CBR3(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2C9(1), CYP2U1(1), CYP4F3(4), EPHX2(2), GGT1(2), GPX4(1), LTA4H(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS1(2), PTGS2(2)	12572883	42	26	42	13	11	8	6	12	5	0	0.310	0.999	1.000
408	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), CREB1(1), ELK1(3), GNAI1(1), GNAS(3), MAPK3(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), RAF1(1), RPS6KA3(2)	11255732	35	16	34	12	10	4	4	8	7	2	0.471	0.999	1.000
409	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(3), ACO1(2), ACO2(2), FH(1), IDH3B(1), OGDHL(2), PC(1), PCK1(3), SDHC(1), SUCLG2(1)	9118253	17	9	17	7	7	4	1	4	1	0	0.511	0.999	1.000
410	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(1)	2698718	6	4	6	6	2	2	0	1	1	0	0.970	0.999	1.000
411	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH6A1(2), AOX1(3), BCKDHA(1), ECHS1(2), EHHADH(1), HIBADH(1), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2)	11635936	38	14	37	13	12	13	2	6	5	0	0.342	1.000	1.000
412	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CRADD(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRADD(1)	7797393	12	7	12	8	6	3	0	1	2	0	0.899	1.000	1.000
413	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), ARHGEF1(1), MYL2(1), MYLK(3), PLCB1(2), PRKCA(3), ROCK1(2)	6665505	13	5	13	6	5	1	3	2	1	1	0.670	1.000	1.000
414	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(2), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HIBCH(1), MLYCD(3), SMS(1), SRM(1)	8718433	35	13	35	13	14	7	3	7	4	0	0.405	1.000	1.000
415	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(8), EP300(3), FYN(1), JAK3(1), STAT5B(2)	7819255	15	6	15	8	4	1	0	9	1	0	0.916	1.000	1.000
416	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(2), PPP3CA(1), PPP3CC(1), SLC2A4(1), YWHAH(1)	6538740	18	4	18	6	5	6	0	3	4	0	0.456	1.000	1.000
417	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), CDK4(1), CDKN1B(1), CEBPB(1), DMC1(2), EGR1(1), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(1), NCOR1(8), NR5A1(1), NRIP1(1), PGR(2), PRLR(1), SMPD1(1), VDR(1), ZP2(1)	11324495	37	13	37	12	9	7	2	12	6	1	0.532	1.000	1.000
418	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(1), BLVRA(2), COX15(1), CP(3), EARS2(1), EPRS(2), FTH1(2), GUSB(2), HCCS(3), MMAB(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1)	13644703	46	21	46	14	14	4	12	15	1	0	0.274	1.000	1.000
419	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(2), MAP3K14(1), NFKB1(1), RELA(1)	2892012	5	1	5	4	1	2	0	1	1	0	0.918	1.000	1.000
420	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), CFLAR(1), CYCS(2), DFFA(1), GAS2(1), LMNA(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(2), TRADD(1)	10782245	16	6	16	7	5	3	1	4	3	0	0.706	1.000	1.000
421	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), PFKL(3), PLCG1(6), RAC1(1), RPS6KB1(1), VAV2(1)	8043001	20	10	19	9	7	7	1	3	2	0	0.632	1.000	1.000
422	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(1), CAPN10(3), CAPN11(2), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(3), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(2), MAPK4(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PIK3R2(1), PTK2(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(2), ROCK2(2), SDCCAG8(1), SHC1(1), SORBS1(1), SOS1(1), TLN1(2), TNS1(2), VAV2(1), VAV3(2), VCL(1)	43281592	108	33	108	27	35	18	13	30	12	0	0.0248	1.000	1.000
423	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), SHC1(1), SOS1(1)	2854607	3	2	3	3	0	0	0	1	2	0	0.931	1.000	1.000
424	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1D(2), EEF2(1), EEF2K(1), EIF1AX(2), EIF2AK3(2), EIF2B4(1), EIF4A1(2), EIF4A2(1), EIF4E(1), EIF4G1(2), EIF4G3(4), GSPT2(4), KIAA0664(5), PABPC1(4), PABPC3(1), PAIP1(1)	14158673	35	23	35	11	9	6	4	9	7	0	0.483	1.000	1.000
425	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMB8(1)	2824261	7	1	7	1	2	1	1	3	0	0	0.328	1.000	1.000
426	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(1), EIF4E(1), FBL(1), LDHB(1), NCL(1)	2880412	7	1	7	2	2	2	1	1	1	0	0.402	1.000	1.000
427	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1)	8772495	15	4	15	8	9	1	1	1	3	0	0.825	1.000	1.000
428	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(4), ASH2L(1), CTCFL(2), DOT1L(2), EHMT1(4), EHMT2(2), EZH1(3), EZH2(1), HCFC1(2), HSF4(1), JMJD6(2), KDM6A(2), MEN1(1), MLL(7), MLL2(12), MLL3(12), MLL4(7), MLL5(2), NSD1(2), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(2), PRDM7(2), PRMT5(1), PRMT6(1), SATB1(2), SETD1A(1), SETD2(6), SETD7(3), SETD8(1), SETDB1(1), SETDB2(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(2), WHSC1L1(3)	37683223	107	37	107	29	30	18	14	32	13	0	0.120	1.000	1.000
429	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), BRD4(1), CDKN2A(2), FLOT1(1), FLOT2(1), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), LNPEP(1), MAPK1(1), MAPK3(1), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPYR1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(4), YWHAH(1), YWHAQ(1), YWHAZ(1)	17745046	50	17	49	15	8	10	6	17	8	1	0.364	1.000	1.000
430	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(2), AXIN1(1), BMP10(1), BMP4(2), BMP5(3), CHRD(1), FZD1(1), MYL2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2)	11733811	21	6	21	4	8	4	2	6	1	0	0.112	1.000	1.000
431	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(6), ACTN3(1), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(1), RAC1(1), SPTAN1(2), TLN1(2)	9213738	21	6	21	9	6	3	4	6	2	0	0.674	1.000	1.000
432	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT2(1), B3GALT5(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(2), FUT6(2), GBGT1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL4(2), ST3GAL6(2), ST6GALNAC3(2), ST8SIA5(2), UGCG(2)	15665817	47	17	47	15	18	6	5	13	5	0	0.316	1.000	1.000
433	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFAT5(3), PDE6B(3), PDE6C(5), SLC6A13(2), TF(1)	11571861	38	16	38	14	13	8	7	7	3	0	0.370	1.000	1.000
434	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(1), HSD11B1(1), HSD17B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SRD5A1(1), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	16229980	48	22	48	16	15	4	10	16	3	0	0.305	1.000	1.000
435	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(2), CNGA3(2), CNGA4(1), CNGB1(1), GNAL(1), PDE1C(5), PRKG1(1), PRKG2(1)	9850175	25	6	25	9	14	4	1	3	3	0	0.334	1.000	1.000
436	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR3(1), MAP3K1(2), NFATC1(1), NFATC2(4), NFKB1(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKAR1A(1), RELA(1)	9031743	19	10	18	9	7	2	1	7	2	0	0.828	1.000	1.000
437	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR161(1), GPR171(1), GPR34(1), GPR75(1), GPR81(1)	3170561	7	2	7	9	0	1	2	2	2	0	0.991	1.000	1.000
438	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(3), ATP5B(1), ATP5G2(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), COX15(1), COX17(1), COX7A1(1), COX7B(1), COX7B2(1), NDUFA10(3), NDUFA9(3), NDUFB11(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), SDHC(1), TCIRG1(1), UQCRC1(2), UQCRH(2)	18012426	44	13	44	14	10	10	3	14	6	1	0.391	1.000	1.000
439	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(2), CD1A(2), CD1B(3), CD1E(3), CD22(1), CD33(1), CD36(3), CD3D(1), CD4(1), CD44(2), CD55(1), CD7(1), CR1(3), CR2(3), CSF1R(3), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), GP5(1), GP9(1), HLA-DRA(2), HLA-DRB5(1), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(2), IL5RA(1), IL6(1), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), MME(2), MS4A1(2), TFRC(1), TPO(4)	26293436	82	24	82	27	20	20	8	26	8	0	0.188	1.000	1.000
440	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), CFLAR(1), CRKL(1), E2F1(1), IL2RB(1), IRS1(2), JAK3(1), MAPK1(1), MAPK3(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(1), STAT5B(2), SYK(1)	10456309	17	8	17	8	2	5	1	5	3	1	0.688	1.000	1.000
441	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(1), FBXW7(1), ITK(1), LAT(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PLCG1(6), PTPRC(4), RAF1(1), RASGRP2(2), RASGRP3(1), SOS1(1), SOS2(4), VAV1(4), ZAP70(3)	17978990	52	17	51	15	18	11	4	11	8	0	0.211	1.000	1.000
442	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), CYCS(2), DAXX(2), FAS(1), MAPKAPK2(1), MAPKAPK3(1)	3660511	8	2	8	4	0	2	2	4	0	0	0.834	1.000	1.000
443	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(5), CAMK4(1), CEBPB(1), CNR1(1), CREBBP(8), CSNK2A1(1), CTLA4(1), EGR3(1), EP300(3), FCGR3A(1), GATA3(1), GRLF1(3), IFNB1(1), IL1B(1), IL6(1), ITK(1), KPNA5(2), MAPK8(1), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(4), RELA(1), RPL13A(1), SFN(2), SLA(2), SP3(2), TRPV6(3), VAV1(4), VAV2(1), VAV3(2)	29366269	86	24	86	27	21	24	4	25	12	0	0.173	1.000	1.000
444	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(1), CREB1(1)	3739229	9	2	9	3	4	3	0	0	2	0	0.412	1.000	1.000
445	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), BMP5(3), BMP6(1), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(1), GLI1(2), GLI2(1), GLI3(2), HHIP(2), LRP2(12), PTCH1(3), SHH(1), SMO(2), SUFU(1), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1), ZIC2(2)	19647341	55	21	55	18	21	11	8	11	4	0	0.197	1.000	1.000
446	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4B(2), INPPL1(4), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6)	13770494	40	19	39	13	10	8	5	12	5	0	0.472	1.000	1.000
447	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), RPN2(1)	4171691	8	2	8	4	2	2	1	2	1	0	0.813	1.000	1.000
448	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(1), BTK(1), CDKN2A(2), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SFN(2), SHC1(1), SOS1(1), SOS2(4), TEC(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	10650499	29	11	29	10	5	4	4	12	4	0	0.630	1.000	1.000
449	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), IMPDH1(2), POLB(1), POLD1(1), POLG(1), PRPS2(3), RRM1(3), SRM(1)	4015447	15	5	15	7	5	4	2	3	1	0	0.666	1.000	1.000
450	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(5), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(3), MAPK7(3), MEF2A(2), MEF2B(1), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), YWHAH(1)	10010504	28	9	28	11	11	7	1	6	3	0	0.472	1.000	1.000
451	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AB1(1), IFI30(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), KIR2DL1(1), KLRC1(1), KLRC2(1), LGMN(1), RFX5(1), RFXANK(1)	14919197	32	13	32	12	6	5	5	11	5	0	0.564	1.000	1.000
452	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(1)	4696560	8	2	8	5	2	3	1	1	1	0	0.813	1.000	1.000
453	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ATP6V0C(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), PLOD1(2), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(1)	11962542	35	10	35	13	16	7	3	4	5	0	0.273	1.000	1.000
454	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), ELK1(3), MAP2K2(1), NGFR(1), PIK3CD(1), SHC1(1), SOS1(1)	4504042	9	3	9	5	3	2	0	3	1	0	0.793	1.000	1.000
455	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), ALDH1A3(3), ALDH3A1(4), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2C9(1), CYP2S1(1), CYP3A7(1), EPHX1(3), GSTA4(1), GSTA5(3), GSTZ1(2), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	18515235	67	32	67	23	20	7	12	22	6	0	0.414	1.000	1.000
456	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(2), COPA(2), GBF1(2), GPLD1(1)	5241404	8	3	8	5	2	2	1	2	1	0	0.867	1.000	1.000
457	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), ALOX5AP(1), GGT1(2), LTA4H(2), PLA2G6(2), PTGS1(2), PTGS2(2)	4872346	12	5	12	6	2	5	2	2	1	0	0.706	1.000	1.000
458	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), CHRM1(1), CHRNA1(2), FLT1(3), FLT4(3), KDR(6), NOS3(5), PDE3A(2), PRKAR1A(1), PRKG1(1), PRKG2(1), RYR2(10), SLC7A1(1), TNNI1(1)	13067595	38	20	38	15	11	6	7	10	4	0	0.497	1.000	1.000
459	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), CREB1(1), EP300(3), NOS3(5)	5493214	10	3	10	6	5	0	2	2	1	0	0.849	1.000	1.000
460	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), DUSP4(1), GCK(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K9(2), MAPK10(1), MAPK7(3), MAPK8(1), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(3), SHC1(1), ZAK(1)	15986569	36	13	36	12	12	5	8	9	2	0	0.442	1.000	1.000
461	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), TNFAIP3(1), TRAF3(1)	5864594	8	3	8	8	5	0	1	1	1	0	0.976	1.000	1.000
462	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2), AXIN1(1), BTRC(1), FZD1(1)	5595688	5	2	5	3	1	1	0	2	1	0	0.897	1.000	1.000
463	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(3), CCKBR(3), CELSR1(8), CELSR2(9), CELSR3(10), CHRM3(2), EMR2(2), EMR3(1), FSHR(2), GHRHR(2), GNRHR(2), GPR116(5), GPR132(3), GPR133(1), GPR143(3), GPR61(2), GPR77(1), GPR84(2), GRM1(5), GRPR(2), HRH4(1), LPHN2(5), LPHN3(3), LTB4R2(1), NTSR1(2), OR8G2(1), P2RY13(1), PTGFR(5), SMO(2), SSTR2(1), TAAR5(1), TSHR(4)	21512059	97	37	97	30	32	20	11	23	11	0	0.0706	1.000	1.000
464	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(1), BRAF(3), CAB39(1), EIF4B(1), MAPK1(1), MAPK3(1), PGF(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), TSC1(2), TSC2(2), ULK2(5), VEGFA(2), VEGFB(1), VEGFC(2)	15954112	46	16	46	16	15	6	8	12	4	1	0.404	1.000	1.000
465	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(4), CANT1(4), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1), PRIM1(1), PRIM2(2), RRM1(3), TK2(3), TXNRD2(2), UCK1(2), UMPS(1), UPP1(1), UPP2(2), UPRT(2)	26135191	83	33	83	27	19	13	10	30	11	0	0.377	1.000	1.000
466	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(1), GSN(1), LMNA(2), LMNB2(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(2), NFKB1(1), NUMA1(6), PRKDC(8), PTK2(1), RASA1(4), RB1(4), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF1B(2), TRADD(1)	22292663	54	23	54	17	15	8	8	14	8	1	0.367	1.000	1.000
467	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CANT1(4), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), NT5C(2), NT5E(1), NT5M(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), RRM1(3), TK2(3), UCK1(2), UMPS(1), UPP1(1)	18497555	55	19	55	19	15	12	5	19	4	0	0.435	1.000	1.000
468	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), DARS2(2), EARS2(1), EPRS(2), FARS2(1), GARS(2), HARS(1), HARS2(1), IARS(1), IARS2(2), LARS(3), MARS(4), MARS2(1), MTFMT(1), NARS2(1), PARS2(1), QARS(1), RARS(2), RARS2(4), SARS2(1), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1)	17532786	41	9	41	12	7	10	4	15	5	0	0.392	1.000	1.000
469	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(1), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), EP400(2), ERCC2(1), ERCC3(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(4), SKIV2L2(2), SMARCA2(1), SMARCA5(1), SPR(1)	20259273	45	14	45	15	14	9	6	10	6	0	0.428	1.000	1.000
470	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(4), CCNA1(1), CCNB1(1), CCND1(1), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CREB3(1), CREB3L1(1), E2F1(1), E2F3(1), E2F5(1), GBA2(1), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MYT1(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLE(7), PRIM1(1), RB1(4), RBL1(2), RPA1(2), TNXB(9), WEE1(1)	24638987	70	24	70	24	16	9	10	19	16	0	0.453	1.000	1.000
471	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(2), FH(1), IDH3B(1), PC(1), PDHA1(2), PDHA2(4), PDK1(2), PDK3(3), PDK4(1), PDP2(1), SDHC(1), SUCLG2(1)	8910981	20	9	20	9	4	4	3	8	1	0	0.694	1.000	1.000
472	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(2), CLK3(3), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF3(3), DDIT3(1), DHX16(2), DHX38(3), DHX8(7), DHX9(2), DICER1(1), FUS(2), LOC440563(2), METTL3(2), NCBP1(1), NONO(1), PAPOLA(5), POLR2A(3), PRPF18(1), PRPF4(1), PRPF4B(2), PRPF8(6), PSKH1(1), PTBP1(1), RNGTT(2), SF3A3(1), SF3B1(5), SF3B2(1), SF4(1), SFRS14(1), SFRS2(1), SFRS4(1), SFRS5(2), SFRS7(1), SFRS8(3), SFRS9(1), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNURF(1), SPOP(2), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), U2AF1(2), U2AF2(1), XRN2(2)	34148182	100	35	99	27	33	19	7	24	17	0	0.244	1.000	1.000
473	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(2), ASCC3(2), ATP13A2(1), DDX19A(2), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX51(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), ENPP1(1), ENPP3(2), EP400(2), ERCC2(1), ERCC3(1), G6PC(4), G6PC2(1), GAA(5), GANC(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), IFIH1(1), LYZL1(1), MGAM(4), MOV10L1(1), PYGB(1), PYGL(3), PYGM(1), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(4), SI(6), SKIV2L2(2), SMARCA2(1), SMARCA5(1), TREH(1), UGDH(1), UGP2(1), UGT1A1(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A7(1), UGT1A8(2), UGT2A1(3), UGT2A3(3), UGT2B10(3), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UXS1(2)	39968690	120	44	120	31	36	20	21	32	11	0	0.0329	1.000	1.000
474	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), ARHGAP5(1), BCAR1(1), BIRC2(1), BRAF(3), CCND1(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), CRKL(1), DIAPH1(3), DOCK1(1), EGF(3), ELK1(3), ERBB2(1), FARP2(1), FLNA(8), FLNB(7), FLNC(7), FLT1(3), FN1(2), FYN(1), GRLF1(3), HGF(3), IBSP(1), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KDR(6), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), MET(6), MYL2(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PARVA(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PGF(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PRKCA(3), PRKCG(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(6), ROCK1(2), ROCK2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TLN1(2), TLN2(3), TNC(3), TNN(7), TNR(4), TNXB(9), VAV1(4), VAV2(1), VAV3(2), VCL(1), VEGFA(2), VEGFB(1), VEGFC(2), VWF(5)	117568737	350	99	349	113	104	77	42	85	39	3	0.0137	1.000	1.000
475	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY7(2), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), AVPR1A(2), AVPR1B(1), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM5(4), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), ERBB2(1), ERBB3(2), ERBB4(3), GNA11(1), GNA14(1), GNAL(1), GNAS(3), GRIN2A(1), GRIN2C(2), GRIN2D(4), GRM1(5), GRM5(2), GRPR(2), HRH1(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), ITPR1(2), ITPR2(11), ITPR3(6), LTB4R2(1), MYLK(3), MYLK2(1), NOS1(2), NOS3(5), NTSR1(2), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(8), PHKA1(2), PHKA2(4), PHKG1(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), PPID(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGER3(1), PTGFR(5), RYR1(10), RYR2(10), RYR3(6), SLC25A5(1), SLC25A6(1), SLC8A2(3), SLC8A3(1), TACR2(1), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(2)	86014816	283	96	281	100	96	53	35	58	40	1	0.0971	1.000	1.000
476	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CALCR(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CNR1(1), CNR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD3(1), DRD5(2), EDNRB(1), F2(2), FPR1(1), FSHR(2), GABBR1(2), GABRA1(7), GABRA3(1), GABRA4(5), GABRA5(1), GABRA6(3), GABRB1(4), GABRB2(2), GABRB3(2), GABRD(2), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(2), GALR1(1), GH1(1), GHR(2), GHRHR(2), GIPR(2), GLP2R(1), GLRA1(1), GLRB(2), GNRHR(2), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(3), GRIA2(2), GRIA3(5), GRIA4(2), GRID1(1), GRID2(3), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(4), GRIK5(2), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), GRIN3A(2), GRM1(5), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM6(2), GRM7(3), GRM8(1), GRPR(2), HCRTR2(2), HRH1(1), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LEPR(1), LTB4R(2), LTB4R2(1), MC3R(1), MC4R(3), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(1), NPY1R(3), NR3C1(2), NTSR1(2), OPRL1(1), OPRM1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(3), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(1), PPYR1(2), PRLR(1), PRSS1(1), PRSS3(1), PTGER3(1), PTGER4(1), PTGFR(5), PTH2R(1), RXFP1(2), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(4), TAAR5(1), TAAR6(1), TACR2(1), TBXA2R(1), TRHR(2), TSHR(4), UTS2R(1), VIPR1(1)	71529312	279	88	279	90	85	57	33	77	27	0	0.0118	1.000	1.000
477	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(2), ACVR1C(1), AKT1(1), ARRB1(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D3(1), CACNA2D4(2), CACNB2(3), CACNB3(1), CACNG1(3), CACNG2(1), CACNG3(2), CACNG7(3), CACNG8(1), CRKL(1), DAXX(2), DDIT3(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP7(1), DUSP9(2), EGF(3), ELK1(3), FAS(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(3), FLNA(8), FLNB(7), FLNC(7), IL1B(1), IL1R1(1), IL1R2(2), KRAS(1), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K8(2), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MRAS(1), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(1), PAK1(2), PDGFA(1), PDGFRA(8), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(3), RASA1(4), RASA2(2), RASGRF1(2), RASGRF2(2), RASGRP2(2), RASGRP3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RRAS(1), SOS1(1), SOS2(4), SRF(2), STK3(2), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), ZAK(1)	89267334	271	86	269	111	86	55	32	61	34	3	0.488	1.000	1.000
478	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(2), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), DSC1(2), DSC2(1), DSC3(4), DSG1(2), DSG2(2), DSG3(2), DSG4(1), FN1(2), GJA1(4), GJA10(1), GJA3(1), GJA4(1), GJA8(2), GJB2(1), GJB6(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(2), KRT1(1), KRT12(1), KRT14(1), KRT15(1), KRT16(3), KRT17(2), KRT2(1), KRT20(3), KRT24(1), KRT25(1), KRT27(1), KRT28(2), KRT3(3), KRT31(1), KRT33A(4), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT39(2), KRT5(4), KRT6B(2), KRT6C(3), KRT7(1), KRT71(2), KRT73(1), KRT75(2), KRT76(1), KRT77(1), KRT78(1), KRT8(3), KRT83(2), KRT84(1), KRT86(2), KRT9(1), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), LMNA(2), LMNB2(2), NES(3), PRPH(1), RELN(6), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VIM(2), VWF(5)	80400410	255	84	254	86	93	61	22	59	19	1	0.0541	1.000	1.000
479	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(2), ACTN2(6), ACTN3(1), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(1), ARHGEF4(3), ARHGEF6(3), ARPC1B(1), ARPC3(1), BAIAP2(2), BCAR1(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(5), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(3), EZR(1), F2(2), FGD3(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(1), FGFR4(3), FN1(2), GIT1(1), GRLF1(3), GSN(1), IQGAP1(9), IQGAP2(3), IQGAP3(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KRAS(1), LIMK1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MRAS(1), MYH10(4), MYH14(3), MYL2(1), MYLK(3), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDGFA(1), PDGFRA(8), PFN4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(2), RRAS(1), SCIN(2), SOS1(1), SOS2(4), SSH2(1), SSH3(1), TIAM1(3), TIAM2(3), TMSL3(1), VAV1(4), VAV2(1), VAV3(2), VCL(1), WAS(2), WASF1(1), WASL(1)	87182345	243	82	242	84	61	48	34	66	32	2	0.176	1.000	1.000
480	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), AMOTL1(1), ASH1L(4), CASK(1), CDK4(1), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(1), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), HCLS1(1), INADL(4), JAM2(3), JAM3(2), KRAS(1), LLGL1(3), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(5), MLLT4(4), MPDZ(6), MRAS(1), MYH1(5), MYH10(4), MYH11(3), MYH13(4), MYH14(3), MYH15(5), MYH2(8), MYH3(6), MYH4(5), MYH6(2), MYH7(5), MYH7B(6), MYH8(7), MYL2(1), NRAS(1), OCLN(1), PARD3(1), PARD6A(1), PPM1J(2), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PPP2R3A(2), PPP2R4(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RAB3B(1), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(1), TJP1(4), TJP2(1), TJP3(1), YES1(2), ZAK(1)	62286358	189	69	189	71	63	30	26	50	19	1	0.372	1.000	1.000
481	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(3), CD44(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(6), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(3), COL4A6(5), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(1), COL6A3(10), COL6A6(2), DAG1(1), FN1(2), FNDC1(2), FNDC3A(3), FNDC5(1), GP5(1), GP9(1), HSPG2(8), IBSP(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), LAMA1(7), LAMA2(5), LAMA3(7), LAMA4(1), LAMA5(10), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), RELN(6), SDC1(1), SDC3(1), SPP1(1), SV2A(2), SV2B(2), SV2C(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VWF(5)	72351113	216	63	216	64	67	56	24	52	16	1	0.0100	1.000	1.000
482	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(5), EFNA1(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(1), EPHA2(2), EPHA3(3), EPHA4(5), EPHA5(2), EPHA6(1), EPHA7(4), EPHA8(2), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(3), FES(2), FYN(1), GNAI1(1), ITGB1(2), KRAS(1), L1CAM(4), LIMK1(2), LRRC4C(4), MAPK1(1), MAPK3(1), MET(6), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NGEF(3), NRAS(1), NRP1(3), NTN4(1), NTNG1(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PLXNA1(7), PLXNA2(4), PLXNA3(4), PLXNB1(4), PLXNB2(5), PLXNB3(3), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC2(1), RASA1(4), RGS3(5), RHOD(1), RND1(1), ROBO1(3), ROBO2(5), ROBO3(1), ROCK1(2), ROCK2(2), SEMA3A(4), SEMA3C(1), SEMA3D(2), SEMA3E(4), SEMA3F(2), SEMA4B(2), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA6A(2), SEMA6B(3), SEMA6C(2), SEMA6D(2), SEMA7A(2), SLIT1(4), SLIT2(3), SLIT3(1), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(1)	63799219	209	62	209	68	62	41	28	58	19	1	0.0631	1.000	1.000
483	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(3), ACVR1B(2), ACVR2A(1), AMHR2(1), CCL11(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CSF1R(3), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(4), EGF(3), EPOR(1), FAS(1), FLT1(3), FLT3(2), FLT4(3), GDF5(1), GH1(1), GHR(2), HGF(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(1), IL17RA(1), IL18RAP(1), IL1B(1), IL1R1(1), IL1R2(2), IL1RAP(1), IL20RA(2), IL22RA1(1), IL23A(1), IL23R(4), IL25(2), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), INHBA(1), INHBB(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEPR(1), LTBR(2), MET(6), MPL(2), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(8), PRLR(1), RELT(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(2), TNFSF14(1), TNFSF15(3), TNFSF8(1), TPO(4), VEGFA(2), VEGFB(1), VEGFC(2), XCL1(1)	56284199	183	59	182	76	47	43	29	40	24	0	0.497	1.000	1.000
484	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADRA1A(2), ADRA1B(2), ADRB2(1), ANXA6(2), ARRB1(2), ATP1B2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), CACNA1A(1), CACNA1B(7), CACNA1D(5), CACNA1E(5), CACNA1S(6), CACNB3(1), CALR(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), GJA1(4), GJA4(1), GJB2(1), GJB6(1), GNA11(1), GNAO1(2), GNB5(1), GRK4(4), GRK5(4), ITPR1(2), ITPR2(11), ITPR3(6), KCNB1(3), KCNJ3(1), KCNJ5(2), MIB1(1), PLCB3(3), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(2), RYR1(10), RYR2(10), RYR3(6), SFN(2), SLC8A3(1), YWHAH(1), YWHAQ(1)	60541758	187	58	187	67	65	35	21	43	22	1	0.180	1.000	1.000
485	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADK(1), ADSL(3), ADSSL1(1), AK5(1), AK7(4), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), CANT1(4), ENPP1(1), ENPP3(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(3), GMPR(1), GMPR2(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5C1B(1), NT5E(1), NT5M(1), PAICS(1), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE7A(1), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1), PPAT(2), PRIM1(1), PRIM2(2), PRPS1L1(1), PRPS2(3), RRM1(3), XDH(7)	52732559	159	56	158	54	53	29	19	42	16	0	0.147	1.000	1.000
486	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(4), CD22(1), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CDH1(3), CDH15(1), CDH2(2), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(1), CNTN2(1), CNTNAP1(4), CNTNAP2(3), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(1), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGAL(2), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(3), JAM3(2), L1CAM(4), MPZ(1), NCAM1(2), NEGR1(2), NEO1(4), NFASC(1), NLGN1(2), NLGN2(3), NLGN3(2), NRCAM(3), NRXN1(5), NRXN3(3), OCLN(1), PDCD1LG2(1), PTPRC(4), PTPRF(3), PTPRM(4), PVR(2), PVRL1(1), SDC1(1), SDC3(1), SELE(4), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(5)	47706524	155	54	154	54	47	41	12	40	15	0	0.0988	1.000	1.000
487	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CSNK1D(1), EGF(3), GJA1(4), GNA11(1), GNAI1(1), GNAS(3), GRM1(5), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(3), NPR1(1), NPR2(2), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), SOS1(1), SOS2(4), TJP1(4), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB2C(3), TUBB3(3), TUBB4(1), TUBB4Q(2), TUBB6(2), TUBB8(1)	41845975	133	53	132	48	46	21	18	25	21	2	0.284	1.000	1.000
488	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA3(2), ADRA1A(2), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCBP2(1), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHML(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD3(1), DRD5(2), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GPR174(1), GPR35(1), GPR37(1), GPR4(1), GPR50(2), GPR6(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), GPR87(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LTB4R(2), MC3R(1), MC4R(3), MC5R(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPY1R(3), NTSR1(2), OPN1SW(1), OPN3(1), OPRL1(1), OPRM1(1), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(2), OR7C1(1), P2RY1(1), P2RY12(1), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(2), PTGER4(1), PTGFR(5), SSTR2(1), SSTR3(2), SSTR4(4), SUCNR1(1), TBXA2R(1), TRHR(2)	39203052	148	52	148	53	48	24	18	43	15	0	0.117	1.000	1.000
489	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ARRB1(2), ATF4(1), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), CREB3(1), GABPA(2), GABPB2(1), GBA2(1), GJA1(4), GNB5(1), GRK4(4), GRK5(4), GUCY1A3(1), IGFBP2(2), IGFBP3(1), IL1B(1), IL6(1), ITPR1(2), ITPR2(11), ITPR3(6), MIB1(1), MYL2(1), MYLK2(1), NFKB1(1), NOS1(2), NOS3(5), PDE4D(3), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(6), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(2), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(2), RLN1(1), RYR1(10), RYR2(10), RYR3(6), SFN(2), TNXB(9), YWHAH(1), YWHAQ(1)	55873772	170	52	169	65	60	26	22	42	19	1	0.389	1.000	1.000
490	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(3), C7orf16(1), CACNA1A(1), GNA11(1), GNAI1(1), GNAO1(2), GNAS(3), GRIA1(3), GRIA2(2), GRIA3(5), GRID2(3), GRM1(5), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IGF1R(3), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(2), NOS3(5), NPR1(1), NPR2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), RYR1(10)	35600821	123	50	123	37	33	21	21	29	17	2	0.125	1.000	1.000
491	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ATF4(1), CACNA1D(5), CACNA1F(4), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(3), GNRHR(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAP3K3(2), MAP3K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLD1(4), PRKCA(3), RAF1(1), SOS1(1), SOS2(4)	40256300	120	48	120	38	46	20	15	22	15	2	0.0746	1.000	1.000
492	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), BRAF(3), CD244(1), FAS(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), ITGAL(2), ITGB2(1), KIR2DL1(1), KLRC1(1), KLRC2(1), KRAS(1), LAT(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(3), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NRAS(1), PAK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(3), PRKCG(1), PTPN11(6), RAC1(1), RAC2(1), RAF1(1), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SYK(1), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(4), VAV2(1), VAV3(2), ZAP70(3)	35398052	114	47	112	39	32	18	17	28	17	2	0.249	1.000	1.000
493	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(10), ACACB(5), AKT1(1), ARAF(1), BRAF(3), CBLB(1), CBLC(1), CRKL(1), ELK1(3), EXOC7(1), FASN(1), FBP1(1), FBP2(2), FLOT1(1), FLOT2(1), G6PC(4), G6PC2(1), GCK(1), GYS1(1), INPP5D(2), INSR(3), IRS1(2), IRS2(1), IRS4(6), KRAS(1), LIPE(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PCK1(3), PDE3A(2), PFKL(3), PHKA1(2), PHKA2(4), PHKG1(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PKLR(1), PPP1CB(1), PPP1R3A(2), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKCI(1), PTPRF(3), PYGB(1), PYGL(3), PYGM(1), RAF1(1), RAPGEF1(3), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(4), SREBF1(4), TSC1(2), TSC2(2)	50539591	136	46	134	53	36	25	13	43	17	2	0.532	1.000	1.000
494	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(2), ACTN2(6), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(3), MYH3(6), MYH6(2), MYH7(5), MYH8(7), MYL1(1), MYL2(1), MYOM1(1), NEB(16), TNNI1(1), TNNT1(1), TNNT3(1), TPM1(5), TPM3(2), TPM4(1), TTN(75), VIM(2)	43911699	150	45	150	48	42	30	17	48	12	1	0.184	1.000	1.000
495	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(2), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(1), CHD8(1), CREBBP(8), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(1), CTBP1(3), CUL1(1), CXXC4(1), DAAM1(1), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), LRP5(4), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NKD2(1), NLK(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PORCN(4), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(3), PRKCA(3), PRKCG(1), RAC1(1), RAC2(1), ROCK1(2), ROCK2(2), RUVBL1(1), SENP2(2), SFRP1(1), SFRP2(1), SFRP4(1), SIAH1(1), SMAD2(3), SMAD3(1), SOX17(2), TBL1XR1(1), TCF7L2(2), VANGL1(1), VANGL2(1), WIF1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1)	51945249	145	43	145	44	47	25	15	41	16	1	0.0755	1.000	1.000
496	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(1), BCAR1(1), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(2), CTNNA3(1), CXCR4(1), CYBB(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), GRLF1(3), ICAM1(2), ITGA4(2), ITGAL(2), ITGAM(1), ITGB1(2), ITGB2(1), ITK(1), JAM2(3), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(4), MMP9(1), MYL2(1), NCF1(1), NCF2(3), NOX1(1), NOX3(1), OCLN(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PLCG2(6), PRKCA(3), PRKCG(1), PTK2(1), PTPN11(6), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(2), SIPA1(2), TXK(1), VAV1(4), VAV2(1), VAV3(2), VCAM1(1), VCL(1)	38911384	120	43	118	50	41	23	12	32	11	1	0.534	1.000	1.000
497	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS2(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(2), INPP5B(2), INPP5D(2), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPR1(2), ITPR2(11), ITPR3(6), OCRL(4), PI4KA(5), PI4KB(1), PIK3C2A(3), PIK3C2G(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(1), PIP5K1C(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(6), PLCZ1(3), PRKCA(3), PRKCG(1), SYNJ1(4), SYNJ2(5)	38778592	120	42	119	35	37	22	15	30	15	1	0.112	1.000	1.000
498	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(2), CDH1(3), CREBBP(8), CSNK2A1(1), CTNNA2(2), CTNNA3(1), EP300(3), ERBB2(1), FARP2(1), FER(1), FGFR1(1), FYN(1), IGF1R(3), INSR(3), IQGAP1(9), LMO7(4), MAPK1(1), MAPK3(1), MET(6), MLLT4(4), NLK(1), PARD3(1), PTPRB(5), PTPRF(3), PTPRJ(2), PTPRM(4), PVRL1(1), PVRL4(2), RAC1(1), RAC2(1), SMAD2(3), SMAD3(1), SORBS1(1), SSX2IP(1), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(4), VCL(1), WAS(2), WASF1(1), WASF3(2), WASL(1), YES1(2)	37848622	114	41	114	36	35	18	11	33	16	1	0.154	1.000	1.000
499	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT1(1), CBLB(1), CBLC(1), CCND1(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(8), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(3), EPOR(1), GH1(1), GHR(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL10RB(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL20RA(2), IL22RA1(1), IL23A(1), IL23R(4), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), IRF9(2), JAK2(3), JAK3(1), LEPR(1), MPL(2), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PIM1(2), PRLR(1), PTPN11(6), SOCS4(1), SOS1(1), SOS2(4), SPRED1(1), SPRED2(2), SPRY1(1), SPRY4(1), STAM2(1), STAT1(2), STAT3(1), STAT4(2), STAT5B(2), STAT6(3), TPO(4), TYK2(5)	45678408	127	40	126	48	29	19	18	48	12	1	0.627	1.000	1.000
500	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADK(1), ADSL(3), AK5(1), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), ATP5B(1), ATP5G2(1), CANT1(4), ENPP1(1), ENPP3(2), ENTPD1(1), GART(3), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE6B(3), PDE6C(5), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), PPAT(2), PRPS1L1(1), PRPS2(3), RRM1(3)	41397427	120	40	120	52	44	26	14	28	8	0	0.636	1.000	1.000
501	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(4), ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(4), ATR(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB1(1), CCNB3(3), CCND1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(2), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC27(3), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CHEK1(3), CHEK2(3), CREBBP(8), CUL1(1), DBF4(4), E2F1(1), E2F3(1), EP300(3), ESPL1(5), FZR1(2), HDAC2(4), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PKMYT1(1), PLK1(1), PRKDC(8), RB1(4), RBL1(2), RBL2(2), SFN(2), SKP2(2), SMAD2(3), SMAD3(1), SMC1A(1), SMC1B(4), TGFB2(2), TGFB3(1), WEE1(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	43575727	142	39	141	44	23	31	22	39	25	2	0.297	1.000	1.000
502	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3(1), CREB3L1(1), CREB3L2(1), CREBBP(8), DVL2(1), DVL3(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAO1(2), GNAS(3), KIT(3), KITLG(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PRKCA(3), PRKCG(1), RAF1(1), TCF7L2(2), TYR(4), TYRP1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1)	35147589	96	39	96	35	36	10	7	27	14	2	0.344	1.000	1.000
503	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(3), B3GNT7(1), C1GALT1(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHST3(2), CHST4(1), CHSY1(1), DAD1(1), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL3(1), FUT8(3), GALNT1(1), GALNT12(2), GALNT13(1), GALNT14(2), GALNT2(2), GALNT4(1), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GANAB(3), GCNT4(2), HS6ST2(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(1), NDST1(2), NDST2(2), NDST3(2), NDST4(1), OGT(6), RPN2(1), ST3GAL1(1), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(4), XYLT1(1), XYLT2(1)	35536693	104	38	104	33	32	19	11	28	14	0	0.261	1.000	1.000
504	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), AKAP11(1), AKAP12(1), AKAP3(1), AKAP4(4), AKAP5(2), AKAP6(8), AKAP7(1), AKAP8(2), AKAP9(5), ARHGEF1(1), GNA11(1), GNA14(1), GNAL(1), GNAO1(2), GNB5(1), ITPR1(2), KCNJ3(1), KRAS(1), NRAS(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE7A(1), PDE7B(2), PDE8A(4), PLCB3(3), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RRAS(1)	37791831	90	36	90	47	30	14	8	23	14	1	0.923	1.000	1.000
505	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(2), ACVRL1(3), AKT1(1), BUB1(3), CDS2(2), CLK1(2), CLK4(1), CSNK2A1(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(2), INPPL1(4), NEK3(1), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PIM2(1), PLCB1(2), PLCB2(2), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(6), PLK3(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), TGFBR1(1), VRK1(3)	35715501	94	36	93	37	27	17	11	23	14	2	0.627	1.000	1.000
506	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	81	ABL1(4), ATM(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB1(1), CCNB3(3), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(2), CDC20(1), CDC25A(1), CDH1(3), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(3), DTX4(1), E2F1(1), E2F3(1), E2F5(1), EP300(3), ESPL1(5), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MPEG1(2), MPL(2), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), PLK1(1), PRKDC(8), PTPRA(4), RB1(4), RBL1(2), SKP2(2), TBC1D8(1), WEE1(1)	35178997	111	31	111	40	20	26	17	29	17	2	0.546	1.000	1.000
507	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOR1(2), ADIPOR2(3), AKT1(1), CAMKK1(1), CAMKK2(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), G6PC(4), G6PC2(1), IRS1(2), IRS2(1), IRS4(6), JAK2(3), JAK3(1), LEPR(1), MAPK10(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIE(1), NPY(1), PCK1(3), PPARA(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(2), PTPN11(6), RELA(1), RXRA(1), RXRG(3), SLC2A1(1), SLC2A4(1), STAT3(1), TNFRSF1B(2), TRADD(1), TYK2(5)	26804589	86	29	84	37	24	17	5	29	11	0	0.753	1.000	1.000
508	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	42	CREBBP(8), CTBP1(3), DTX2(1), DTX3L(1), DTX4(1), DVL2(1), DVL3(1), EP300(3), HDAC2(4), JAG1(2), LFNG(1), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NCOR2(3), NCSTN(3), NOTCH2(9), NOTCH3(4), NOTCH4(8), NUMBL(2), RBPJ(2), RBPJL(1), SNW1(1)	21028888	65	28	65	27	19	10	4	17	14	1	0.754	1.000	1.000
509	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(1), CBLB(1), CBLC(1), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FYN(1), ITK(1), KRAS(1), LAT(1), MAP3K14(1), MAP3K8(2), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(3), PAK6(2), PAK7(2), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(2), PTPRC(4), SOS1(1), SOS2(4), TEC(1), VAV1(4), VAV2(1), VAV3(2), ZAP70(3)	31548182	85	28	84	33	27	16	7	22	13	0	0.543	1.000	1.000
510	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(3), CREB1(1), DAXX(2), ELK1(3), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(2), MAP3K5(2), MAP3K8(2), MAP3K9(2), MAP4K3(1), MAP4K4(2), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), NFKB1(1), PAK1(2), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1)	30685412	82	28	81	32	24	12	13	22	9	2	0.568	1.000	1.000
511	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(3), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVRL1(3), AMHR2(1), BMP4(2), BMP5(3), BMP6(1), CHRD(1), CREBBP(8), CUL1(1), DCN(1), E2F5(1), EP300(3), GDF5(1), GDF6(1), INHBA(1), INHBB(1), INHBE(1), LTBP1(4), MAPK1(1), MAPK3(1), NODAL(1), PITX2(3), PPP2CA(3), PPP2CB(1), PPP2R2A(2), PPP2R2C(3), RBL1(2), RBL2(2), ROCK1(2), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(3), SMAD2(3), SMAD3(1), SMAD5(1), SMAD7(2), SMAD9(2), SMURF1(1), SMURF2(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(1), THBS2(4), THBS3(2), THBS4(3)	31925093	98	27	98	31	31	15	13	31	7	1	0.157	1.000	1.000
512	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(1), CCL5(1), CD40(1), CXCL9(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(1), IFNB1(1), IKBKE(4), IL12B(2), IL1B(1), IL6(1), IRAK4(1), IRF7(2), LBP(1), MAP2K2(1), MAP2K3(2), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(1), SPP1(1), STAT1(2), TBK1(2), TICAM1(1), TLR1(2), TLR3(5), TLR4(1), TLR6(2), TLR7(3), TLR9(1), TRAF3(1)	27753498	71	27	70	33	21	16	11	16	5	2	0.707	1.000	1.000
513	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(2), MC3R(1), MC4R(3), MC5R(1), NMBR(3), NPY1R(3), NTSR1(2), OPRL1(1), OPRM1(1), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(4), TACR2(1), TRHR(2), TSHR(4)	16894569	60	26	60	27	20	10	10	17	3	0	0.553	1.000	1.000
514	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(3), ABCA12(3), ABCA13(9), ABCA2(3), ABCA3(3), ABCA4(4), ABCA5(2), ABCA6(5), ABCA7(2), ABCA8(3), ABCA9(2), ABCB1(3), ABCB11(1), ABCB4(4), ABCB5(3), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(4), ABCC10(7), ABCC11(3), ABCC12(4), ABCC3(6), ABCC4(2), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(4), ABCD1(2), ABCG1(1), ABCG4(2), ABCG5(3), ABCG8(3), CFTR(1)	38104499	104	25	104	43	30	18	15	30	10	1	0.617	1.000	1.000
515	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(1), ATM(4), ATR(4), BAI1(2), BAX(1), CCNB1(1), CCNB3(3), CCND1(1), CCNE2(1), CCNG2(1), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(3), CYCS(2), DDB2(1), EI24(2), FAS(1), GTSE1(4), IGFBP3(1), LRDD(1), MDM2(2), MDM4(1), PPM1D(1), RFWD2(3), SERPINE1(1), SESN1(1), SESN3(1), SFN(2), SIAH1(1), STEAP3(1), THBS1(1), TSC2(2), ZMAT3(3)	20539907	61	24	61	24	14	10	11	19	7	0	0.576	1.000	1.000
516	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), AOX1(3), CAT(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2C9(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), KMO(2), TDO2(1), TPH1(2), WARS2(2)	17771660	48	23	48	21	18	10	3	10	7	0	0.719	1.000	1.000
517	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), AOX1(3), CAT(2), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2), KMO(2), LCMT1(2), LCMT2(1), LNX1(3), METTL2B(3), METTL6(1), NFX1(1), OGDHL(2), PRMT2(2), PRMT5(1), PRMT6(1), TDO2(1), TPH1(2), TPH2(1), WARS2(2)	19576881	58	21	58	25	22	11	4	13	8	0	0.644	1.000	1.000
518	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(1), ACOX1(2), ACOX2(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ANGPTL4(1), APOA1(1), AQP7(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP7A1(1), EHHADH(1), FABP7(1), FADS2(2), GK2(3), HMGCS2(2), LPL(2), ME1(1), NR1H3(4), PCK1(3), PPARA(2), PPARG(1), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A5(3), SORBS1(1), UBC(3)	21137211	62	21	61	25	14	15	9	20	4	0	0.574	1.000	1.000
519	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), IFITM1(1), INPP5D(2), KRAS(1), LILRB3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIE(1), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PLCG2(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(1), SYK(1), VAV1(4), VAV2(1), VAV3(2)	22792446	60	21	60	27	24	11	4	14	7	0	0.665	1.000	1.000
520	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	ELK1(3), GNAS(3), IGF1R(3), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), PDGFRA(8), PPP2CA(3), PTPRR(3), RAF1(1), RPS6KA1(2), SHC1(1), SOS1(1), STAT3(1)	9816917	35	20	34	16	6	8	4	9	7	1	0.820	1.000	1.000
521	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACAT2(1), ACOX1(2), ACOX3(3), ACSL1(1), ACSL3(2), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), DCI(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2)	15825533	51	20	51	23	15	8	5	15	8	0	0.808	1.000	1.000
522	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), GOT1(2), NOS1(2), NOS3(5), OAT(1), ODC1(2), P4HA1(1), RARS(2), SMS(1)	14293713	45	19	45	23	16	9	4	10	6	0	0.850	1.000	1.000
523	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH1A3(3), ALDH3A1(4), DDC(1), EPX(2), ESCO2(2), GOT1(2), HPD(1), LPO(5), MPO(2), MYST3(1), MYST4(9), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(4)	11047347	43	19	42	16	14	9	4	8	8	0	0.527	1.000	1.000
524	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(4), AOX1(3), DDC(1), FAH(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), TAT(1), TH(1), TPO(4), TYR(4)	10247796	42	19	42	17	15	3	5	14	5	0	0.590	1.000	1.000
525	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(1), ELK1(3), HGF(3), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(6), PAK1(2), PTK2(1), PTPN11(6), RAF1(1), RASA1(4), SOS1(1), STAT3(1)	12752205	38	18	37	16	10	5	4	11	7	1	0.662	1.000	1.000
526	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(2), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(2), SLC27A5(3), SOAT1(1), SOAT2(2), SRD5A1(1)	10211068	45	17	45	18	15	5	4	17	4	0	0.690	1.000	1.000
527	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(1), FTCD(1), HAL(1), HARS(1), HARS2(1), HDC(2), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRPS2(3), UROC1(1)	12810338	42	17	42	19	19	8	3	9	3	0	0.573	1.000	1.000
528	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), BCR(1), BLNK(2), BTK(1), CSK(1), DAG1(1), EPHB2(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PI3(1), PIK3CD(1), PLCG2(6), PPP1R13B(1), RAF1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), SYK(1), VAV1(4)	15785017	39	17	39	16	16	6	4	9	4	0	0.560	1.000	1.000
529	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(4), ATR(4), BRCA1(1), CCNB1(1), CDC25A(1), CDC34(1), CHEK1(3), CHEK2(3), EP300(3), MDM2(2), MYT1(3), PRKDC(8), RPS6KA1(2), WEE1(1), YWHAH(1), YWHAQ(1)	13216021	39	16	39	14	5	7	4	14	8	1	0.720	1.000	1.000
530	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AGXT(2), AGXT2(1), ALAS1(1), ATP6V0C(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PLCB2(2), PLCG1(6), PLCG2(6), SARDH(1), SHMT1(1)	13599866	33	16	32	16	15	11	2	4	1	0	0.653	1.000	1.000
531	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), EPRS(2), GLUD1(3), GLUD2(1), GOT1(2), LAP3(1), NOS1(2), NOS3(5), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4)	11613838	38	16	38	16	11	8	3	12	4	0	0.697	1.000	1.000
532	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NAGLU(3), NEU1(1), NEU2(2), NEU3(1), SPAM1(1)	11131660	31	16	31	15	9	3	5	9	5	0	0.886	1.000	1.000
533	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(2), AXIN1(1), CCND1(1), CSNK1E(1), DVL2(1), DVL3(1), FZD1(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), MAPK10(1), MAPK9(1), PAFAH1B1(4), PLAU(1), PPP2R5C(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(2), RAC1(1), SFRP4(1), WNT11(4), WNT2(2), WNT2B(1), WNT5B(1), WNT7A(1)	19376916	42	16	42	18	14	4	8	10	5	1	0.611	1.000	1.000
534	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ADC(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(2), SMS(1), SRM(1)	9528850	30	15	30	13	10	4	3	6	7	0	0.712	1.000	1.000
535	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ALDH7A1(2), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), HSD17B4(2), NSD1(2), OGDHL(2), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(3), SETDB1(1), SHMT1(1), SUV39H1(1), TMLHE(1)	18763915	48	15	48	22	22	7	2	8	9	0	0.712	1.000	1.000
536	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), AKT1(1), APAF1(1), ATM(4), BAX(1), BIRC2(1), CFLAR(1), CSF2RB(1), CYCS(2), DFFA(1), FAS(1), IL1B(1), IL1R1(1), IL1RAP(1), IL3RA(2), IRAK2(1), IRAK3(4), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R3(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKAR1A(1), RELA(1), RIPK1(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1)	25495133	48	15	48	28	11	8	6	15	8	0	0.985	1.000	1.000
537	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH1A3(3), ALDH3A1(4), DDC(1), EPX(2), GOT1(2), HPD(1), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(4)	7103039	28	15	28	14	13	6	3	3	3	0	0.613	1.000	1.000
538	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(2), DLG4(3), LPA(5), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(4), PLD3(1), PTK2(1), RDX(5), ROCK1(2), ROCK2(2), SERPINA4(1), SRF(2), TBXA2R(1)	15832845	47	15	47	18	13	8	6	15	5	0	0.620	1.000	1.000
539	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	EIF2B4(1), FLT1(3), FLT4(3), KDR(6), NOS3(5), PLCG1(6), PRKCA(3), PTK2(1), SHC1(1)	9769161	29	15	28	16	9	5	6	5	3	1	0.873	1.000	1.000
540	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(1), ADH1B(1), ADH1C(2), ADH6(3), ADH7(1), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CEL(1), CYP27A1(1), CYP7A1(1), SOAT2(2), SRD5A1(1)	7501490	31	14	31	13	11	4	3	11	2	0	0.634	1.000	1.000
541	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(1), CCND1(1), CREBBP(8), EP300(3), ERCC3(1), ESR1(1), GRIP1(1), GTF2E1(3), GTF2F1(2), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), NCOR2(3), NRIP1(1), PELP1(1), POLR2A(3)	14916144	40	14	40	16	11	5	2	14	8	0	0.769	1.000	1.000
542	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(1), ELK1(3), FPR1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), PAK1(2), PIK3C2G(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1)	12360821	37	14	37	18	15	6	1	8	6	1	0.787	1.000	1.000
543	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5D(1), GRM1(5), GRM2(4), GRM3(4), GRM4(2), GRM5(2), GRM7(3), GRM8(1)	6783130	26	14	26	13	9	4	2	8	3	0	0.859	1.000	1.000
544	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), ASPA(1), CNDP1(2), DDC(1), HAL(1), HARS(1), HDC(2), PRPS2(3)	7898599	25	14	25	14	13	5	2	3	2	0	0.787	1.000	1.000
545	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(2), EGF(3), ETS1(3), HOXA7(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), PPP2CA(3), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(2), RAF1(1), RELA(1), RIPK1(1), TNFRSF1B(2)	14998340	37	14	37	15	12	7	4	7	5	2	0.471	1.000	1.000
546	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PDK1(2), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(4), PLD3(1)	14479365	42	14	42	19	13	7	8	12	2	0	0.693	1.000	1.000
547	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(2), APC(2), AXIN1(1), CSNK1A1(2), DACT1(2), DKK1(1), DKK2(2), DKK4(2), LRP1(15), NKD2(1), PTPRA(4), SENP2(2), SFRP1(1), WIF1(2)	13021838	40	14	40	15	12	8	3	13	4	0	0.615	1.000	1.000
548	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(2), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(4), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), MLYCD(3), SMS(1)	9385429	33	13	33	14	12	8	2	7	4	0	0.563	1.000	1.000
549	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(2), C2(2), C3(9), C5(4), C6(2), C7(4), C8A(1), C8B(3)	6711054	32	13	32	13	8	5	3	11	5	0	0.619	1.000	1.000
550	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(1), AKT1(1), GNAI1(1), ITGAV(2), ITGB3(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(8), PLCB1(2), PRKCA(3), PTK2(1), RAC1(1), SMPD1(1), SMPD2(1)	7650435	27	13	26	11	4	7	3	5	6	2	0.584	1.000	1.000
551	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN2A(1), GRIN2B(4), GRIN2C(2), GRIN2D(4), NOS1(2), PPP3CA(1), PPP3CC(1), PRKAR1A(1), PRKCA(3)	8248254	22	13	22	10	7	3	3	6	2	1	0.650	1.000	1.000
552	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(6), FAU(1), IL6ST(2), MRPL19(2), RPL10(3), RPL13A(1), RPL15(1), RPL18A(1), RPL23(1), RPL29(1), RPL32(1), RPL36(1), RPL5(1), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPS4X(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SLC36A2(1), TBC1D10C(1), UBC(3)	16908600	46	13	46	16	13	7	6	14	6	0	0.618	1.000	1.000
553	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(2), PI3(1), PIK3C2G(1), PIK3CD(1), RPS4X(2), SGCB(1)	14513295	36	13	36	17	7	4	8	13	3	1	0.883	1.000	1.000
554	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(1), ELTD1(1), EMR1(2), EMR2(2), GHRHR(2), GIPR(2), GLP2R(1), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(3), VIPR1(1)	8626311	26	12	26	13	5	5	6	10	0	0	0.861	1.000	1.000
555	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB1(1), CREB3(1), EEF2K(1), EIF4E(1), ELK1(3), IL1R1(1), MAP2K3(2), MAP3K4(2), MAP3K5(2), MAPK1(1), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MYEF2(2), NFKB1(1), NR2C2(1), SRF(2)	10748098	28	12	28	14	8	4	6	7	3	0	0.848	1.000	1.000
556	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(3), APOA1(1), APOA4(2), APOE(1), CETP(1), CYP7A1(1), LIPC(1), LPL(2), LRP1(15), SOAT1(1)	8838605	28	12	28	12	10	6	1	9	2	0	0.663	1.000	1.000
557	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(1), CXCR4(1), GNAI1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(3), PTK2(1), RAF1(1), RELA(1)	7704031	19	11	18	15	5	3	3	3	3	2	0.983	1.000	1.000
558	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1)	6576644	18	11	18	13	6	2	2	6	2	0	0.983	1.000	1.000
559	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(3), CUL1(1), CUL2(3), CUL3(1), FBXW7(1), FZR1(2), SKP2(2), SMURF1(1), SMURF2(2), UBE2D4(2), WWP1(3)	12995559	33	11	32	18	6	5	6	11	5	0	0.967	1.000	1.000
560	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(1), ANXA3(1), ANXA6(2), EDNRB(1), HSD11B1(1), PLA2G4A(4), PTGER4(1), PTGFR(5), PTGS1(2), PTGS2(2), SCGB1A1(2)	6665309	24	11	24	10	7	3	3	8	3	0	0.726	1.000	1.000
561	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(1), F2(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), MYEF2(2), PLD1(4), PLD3(1), PTK2(1), RAF1(1), RASAL1(2), TEC(1), VAV1(4)	8857628	29	11	29	10	7	8	1	11	2	0	0.445	1.000	1.000
562	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	ELK1(3), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), PPARA(2), RELA(1), TLR10(4), TLR3(5), TLR4(1), TLR6(2), TLR7(3), TLR9(1)	11792859	29	11	28	15	9	6	5	7	2	0	0.844	1.000	1.000
563	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAX(1), BIRC2(1), CYCS(2), FAS(1), MAP3K1(2), MAP3K14(1), MAPK10(1), MDM2(2), NFKB1(1), PARP1(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1)	11803447	20	10	20	10	6	2	2	6	4	0	0.829	1.000	1.000
564	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), CASP1(1), CASP4(1), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(1), FAS(1), IKBKE(4), NFKB1(1), NGFR(1), NR3C1(2), PTPN13(1), RIPK1(1), SFRS2IP(2), TFG(1), TNFRSF1B(2), TRADD(1), TRAF3(1)	14024116	31	10	31	17	11	5	1	8	6	0	0.901	1.000	1.000
565	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), IRS1(2), IRS2(1), JAK3(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3)	10553541	21	10	21	10	4	4	2	8	2	1	0.789	1.000	1.000
566	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAX(1), BCL2L11(1), BIRC2(1), CASP1(1), CASP4(1), CYCS(2), DFFA(1), FAS(1), HELLS(2), IRF1(4), IRF2(1), IRF4(1), IRF6(1), IRF7(2), MAP3K1(2), MAPK10(1), MDM2(2), NFKB1(1), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TNFRSF21(2), TRADD(1), TRAF3(1)	18202369	38	9	38	16	16	6	2	8	6	0	0.646	1.000	1.000
567	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(3), E2F1(1), ETS1(3), ETV3(1), HDAC2(4), HDAC5(1), NCOR2(3), RBL1(2), RBL2(2), SIN3A(2), SIN3B(1)	8395269	23	9	23	10	5	4	1	6	7	0	0.767	1.000	1.000
568	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(2), EXTL1(2), EXTL3(1), HS6ST2(3), NDST1(2), NDST2(2), NDST3(2), NDST4(1)	6678595	17	9	17	8	9	1	2	5	0	0	0.764	1.000	1.000
569	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3A(5), POLR3B(2), POLR3GL(1), POLR3K(1)	7586129	23	9	23	10	7	2	3	9	2	0	0.718	1.000	1.000
570	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), AXIN1(1), CREBBP(8), EP300(3), FZD1(1), LDB1(2), PITX2(3), TRRAP(5)	10708128	25	9	25	12	8	4	1	11	1	0	0.797	1.000	1.000
571	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(1), GTF2E1(3), GTF2H1(1), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(2), POLR2C(2), POLR2G(1), POLR3B(2), POLR3D(1), POLR3K(1), TAF9(2)	11322716	27	9	27	16	9	4	2	10	2	0	0.926	1.000	1.000
572	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(4), MARS(4), MARS2(1), MTFMT(1), MTR(2), SRM(1), TAT(1)	6703499	26	8	26	11	6	5	1	11	2	1	0.626	1.000	1.000
573	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLB(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLG(1), POLH(1), POLI(3), POLK(1), POLL(1), POLM(2), POLQ(1), PRIM1(1), PRIM2(2), REV1(2), REV3L(2)	13060086	32	8	32	13	6	5	4	12	5	0	0.827	1.000	1.000
574	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IL1B(1), IL1R1(1), IL1RAP(1), IL6(1), IRAK2(1), IRAK3(4), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1)	9570724	21	8	21	10	6	4	4	5	2	0	0.771	1.000	1.000
575	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN2(6), ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), SOS1(1), TLN1(2), VCL(1)	15221061	31	8	31	14	10	6	4	8	2	1	0.694	1.000	1.000
576	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(1), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1), TGFB2(2), TGFB3(1)	6457092	13	8	13	10	4	2	3	3	1	0	0.946	1.000	1.000
577	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIE(1), NFKBIL2(1), PIK3CD(1), TRAF3(1), TRAF5(1)	9617582	23	8	23	10	9	4	2	5	2	1	0.583	1.000	1.000
578	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), CREB1(1), CREB3(1), DUSP4(1), DUSP9(2), EEF2K(1), EIF4E(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(1), SOS2(4), TRAF3(1)	9534233	29	8	29	12	8	3	5	9	3	1	0.664	1.000	1.000
579	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(4), BRCA1(1), CHEK1(3), CHEK2(3), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(1), RAD50(2), RBBP8(2), RELA(1)	9363030	26	7	26	11	6	7	3	7	3	0	0.764	1.000	1.000
580	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(2), AXIN1(1), CCND1(1), FZD1(1), GJA1(4), GNAI1(1), LBP(1), NFKB1(1), PPP2CA(3), RELA(1), TLR4(1)	8704979	18	7	18	10	6	3	1	6	2	0	0.887	1.000	1.000
581	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPNS1(1), CAPNS2(1), EGF(3), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKAR1A(1), PTK2(1), TLN1(2)	9699140	19	7	19	12	6	1	4	6	1	1	0.943	1.000	1.000
582	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(8), EP300(3), IL1B(1), MAP2K3(2), MAP3K14(1), NFKB1(1), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(2)	9591922	22	7	22	12	5	3	2	10	2	0	0.923	1.000	1.000
583	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDK2(1), CDT1(1), DIAPH2(1), GMNN(1), MCM10(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), ORC1L(2), ORC2L(1), ORC3L(1), ORC4L(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), PRIM1(1), RFC4(2), RPA1(2), UBC(3)	16361207	42	6	42	20	9	6	6	15	6	0	0.857	1.000	1.000
584	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR24(2), DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NSDHL(2), SC4MOL(1), SQLE(1)	6224796	15	6	15	9	6	1	5	3	0	0	0.891	1.000	1.000
585	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PHGDH(1), PIPOX(1), SARDH(1), SARS2(1), SHMT1(1), TARS2(1)	13804739	24	6	24	15	9	9	2	3	1	0	0.882	1.000	1.000
586	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(1), MAP3K1(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1)	7864709	12	6	12	12	7	0	1	1	3	0	0.993	1.000	1.000
587	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(8), EP300(3), HDAC3(1), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1)	7222668	18	6	18	11	6	1	0	8	3	0	0.958	1.000	1.000
588	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(2), G6PD(2), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTZ1(2)	5306649	11	5	11	10	5	3	2	1	0	0	0.952	1.000	1.000
589	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(2), G6PD(2), GCLC(1), GGT1(2), GPX4(1), GSTA4(1), GSTA5(3), GSTZ1(2), OPLAH(2)	6560408	16	5	16	11	7	5	2	2	0	0	0.849	1.000	1.000
590	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(2), ACOX3(3), FADS2(2), FASN(1), SCD(1)	4628942	9	5	9	11	2	1	0	4	2	0	0.996	1.000	1.000
591	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(6), ACTN3(1), BCAR1(1), CSK(1), CTNNA2(2), PTK2(1), VCL(1)	6191959	13	4	13	6	6	3	0	4	0	0	0.642	1.000	1.000
592	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), FTCD(1), GART(3), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1)	6119790	19	4	19	10	5	6	2	4	1	1	0.747	1.000	1.000
593	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(3), DNMT1(3), MTNR1A(1), PTGER4(1), PTGFR(5), TBXA2R(1)	3605223	15	4	15	10	4	2	0	8	1	0	0.937	1.000	1.000
594	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), NCKAP1(2), RAC1(1), WASF1(1), WASF3(2), WASL(1)	4938808	11	3	11	5	2	3	1	5	0	0	0.737	1.000	1.000
595	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), CES1(1)	1951690	3	3	3	3	1	1	1	0	0	0	0.904	1.000	1.000
596	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(2)	1284645	4	3	4	3	1	0	0	3	0	0	0.915	1.000	1.000
597	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2)	3728598	4	3	4	4	1	1	1	1	0	0	0.954	1.000	1.000
598	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST3GAL4(2)	1828757	3	3	3	3	2	0	0	1	0	0	0.946	1.000	1.000
599	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(2), APOBEC3F(1), APOBEC3G(1), APOBEC4(1)	2367857	5	3	5	5	2	0	0	3	0	0	0.980	1.000	1.000
600	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), RELN(6), VLDLR(1)	4529648	8	3	8	9	2	4	0	2	0	0	0.988	1.000	1.000
601	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(1), GLI3(2), PRKAR1A(1), SHH(1), SMO(2), SUFU(1)	5373568	9	3	9	5	1	5	0	3	0	0	0.722	1.000	1.000
602	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT2(2)	1972451	3	2	3	3	1	0	1	1	0	0	0.969	1.000	1.000
603	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11B1(1), HSD11B1(1)	2979467	3	2	3	3	1	0	1	1	0	0	0.922	1.000	1.000
604	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1)	5370493	14	2	14	9	3	2	2	7	0	0	0.938	1.000	1.000
605	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11B1(1), HSD11B1(1)	2979467	3	2	3	3	1	0	1	1	0	0	0.922	1.000	1.000
606	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1), PPP2CA(3)	2996496	9	2	9	5	2	0	3	4	0	0	0.871	1.000	1.000
607	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR2(1), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF11A(2)	3581656	7	2	7	7	1	1	1	4	0	0	0.978	1.000	1.000
608	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2)	2033818	2	2	2	3	1	0	1	0	0	0	0.979	1.000	1.000
609	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(3), FYN(1), THBS1(1)	2388173	5	2	5	4	2	2	1	0	0	0	0.840	1.000	1.000
610	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(2), FH(1)	2784013	3	1	3	5	2	0	0	1	0	0	0.986	1.000	1.000
611	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1)	1966210	1	1	1	2	0	0	1	0	0	0	0.971	1.000	1.000
612	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT2A1(2), SUOX(1)	1975657	4	1	4	3	0	1	0	3	0	0	0.935	1.000	1.000
613	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		233896	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		164465	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		494927	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		553302	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
