PAthway Representation and Analysis by Direct Inference on Graphical Models (PARADIGM) predicts the activity of a diverse set of molecular concepts such as genes, complexes, and processes. The predicted activities are called Inferred Pathway Levels (IPLs) and are derived from a probabilistic belief propagation strategy that incorporates multimodal data such as copy number and gene expression estimates with a concept's pathway context.
There were 52 significant pathways identified in this analysis.
Pathway.Name | Avg.Num.Perturbations |
---|---|
IL4-mediated signaling events | 35 |
IL23-mediated signaling events | 35 |
Ephrin A reverse signaling | 31 |
Wnt signaling | 29 |
Signaling mediated by p38-alpha and p38-beta | 27 |
amb2 Integrin signaling | 24 |
Noncanonical Wnt signaling pathway | 23 |
BCR signaling pathway | 23 |
Syndecan-1-mediated signaling events | 22 |
Glypican 1 network | 22 |
The following list describes the columns found in Table 2.
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Pathway.Name = Full pathway name of curated PARADIGM pathway
-
Significance.Ratio = (Ave.Num.Perturbations)/ (Cohort Size) where Cohort Size is 192 . Pathway is significant if Significance.Ratio > 0.05 .
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Avg.Num.Perturbations = Average number of samples with perturbations across the pathway concepts determined by a background permutation model (>2 standard deviations away from the permuted distribution)
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Total.Perturbations = Total number of perturbed concepts across all samples (>2 standard deviations away from the permuted distribution)
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Num.Entities = Number of concepts that belong to the pathway
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Min.Mean.Truth = Minimum IPL for concepts in the pathway among real samples
-
Max.Mean.Truth = Maximum IPL for concepts in the pathway among real samples
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Min.Mean.Within = Minimum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)
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Max.Mean.Within = Maximum IPL for concepts in the pathway among null samples using "within permutation" (values are permuted across genes)
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Min.Mean.Any = Minimum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes)
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Max.Mean.Any = Maximum IPL for concepts in the pathway among null samples using "any permutation" (values are permuted across samples and genes).
Pathway.Name | Significance.Ratio | Avg.Num.Perturbations | Total.Perturbations | Num.Entities | Min.Mean.Truth | Max.Mean.Truth | Min.Mean.Within | Max.Mean.Within | Min.Mean.Any | Max.Mean.Within.1 |
---|---|---|---|---|---|---|---|---|---|---|
IL4-mediated signaling events | 0.1823 | 35 | 3217 | 91 | -0.77 | 0.7 | 1000 | -1000 | -0.15 | -1000 |
IL23-mediated signaling events | 0.1823 | 35 | 2107 | 60 | -0.57 | 0.012 | 1000 | -1000 | -0.15 | -1000 |
Ephrin A reverse signaling | 0.1615 | 31 | 218 | 7 | -0.11 | 0 | 1000 | -1000 | -0.019 | -1000 |
Wnt signaling | 0.1510 | 29 | 209 | 7 | -0.16 | 0.005 | 1000 | -1000 | -0.024 | -1000 |
Signaling mediated by p38-alpha and p38-beta | 0.1406 | 27 | 1225 | 44 | -0.21 | 0.012 | 1000 | -1000 | -0.05 | -1000 |
amb2 Integrin signaling | 0.1250 | 24 | 1969 | 82 | -0.21 | 0.016 | 1000 | -1000 | -0.068 | -1000 |
Noncanonical Wnt signaling pathway | 0.1198 | 23 | 606 | 26 | -0.16 | 0.012 | 1000 | -1000 | -0.053 | -1000 |
BCR signaling pathway | 0.1198 | 23 | 2318 | 99 | -0.23 | 0.012 | 1000 | -1000 | -0.074 | -1000 |
Syndecan-1-mediated signaling events | 0.1146 | 22 | 767 | 34 | -0.17 | 0.012 | 1000 | -1000 | -0.054 | -1000 |
Glypican 1 network | 0.1146 | 22 | 1065 | 48 | -0.21 | 0.014 | 1000 | -1000 | -0.039 | -1000 |
Calcium signaling in the CD4+ TCR pathway | 0.1146 | 22 | 701 | 31 | -0.28 | 0.012 | 1000 | -1000 | -0.083 | -1000 |
IL12-mediated signaling events | 0.1094 | 21 | 1880 | 87 | -0.32 | 0.055 | 1000 | -1000 | -0.12 | -1000 |
Signaling events mediated by the Hedgehog family | 0.1094 | 21 | 1108 | 52 | -0.14 | 0.08 | 1000 | -1000 | -0.047 | -1000 |
TCR signaling in naïve CD8+ T cells | 0.1094 | 21 | 1957 | 93 | -0.18 | 0.064 | 1000 | -1000 | -0.075 | -1000 |
HIF-1-alpha transcription factor network | 0.1042 | 20 | 1578 | 76 | -0.38 | 0.019 | 1000 | -1000 | -0.15 | -1000 |
Reelin signaling pathway | 0.1042 | 20 | 1151 | 56 | -0.17 | 0.018 | 1000 | -1000 | -0.066 | -1000 |
Ephrin B reverse signaling | 0.1042 | 20 | 972 | 48 | -0.17 | 0.047 | 1000 | -1000 | -0.063 | -1000 |
Calcineurin-regulated NFAT-dependent transcription in lymphocytes | 0.1042 | 20 | 1373 | 68 | -0.39 | 0.16 | 1000 | -1000 | -0.12 | -1000 |
Syndecan-4-mediated signaling events | 0.1042 | 20 | 1355 | 67 | -0.18 | 0.03 | 1000 | -1000 | -0.086 | -1000 |
p75(NTR)-mediated signaling | 0.0990 | 19 | 2475 | 125 | -0.18 | 0.036 | 1000 | -1000 | -0.092 | -1000 |
Signaling events regulated by Ret tyrosine kinase | 0.0990 | 19 | 1567 | 82 | -0.16 | 0.012 | 1000 | -1000 | -0.077 | -1000 |
Endothelins | 0.0938 | 18 | 1814 | 96 | -0.2 | 0.012 | 1000 | -1000 | -0.08 | -1000 |
TCGA08_retinoblastoma | 0.0938 | 18 | 147 | 8 | -0.055 | 0.027 | 1000 | -1000 | -0.018 | -1000 |
EGFR-dependent Endothelin signaling events | 0.0938 | 18 | 395 | 21 | -0.2 | 0.018 | 1000 | -1000 | -0.064 | -1000 |
BMP receptor signaling | 0.0885 | 17 | 1397 | 81 | -0.22 | 0.031 | 1000 | -1000 | -0.085 | -1000 |
Nephrin/Neph1 signaling in the kidney podocyte | 0.0833 | 16 | 560 | 34 | -0.074 | 0.012 | 1000 | -1000 | -0.039 | -1000 |
Thromboxane A2 receptor signaling | 0.0833 | 16 | 1694 | 105 | -0.2 | 0.056 | 1000 | -1000 | -0.059 | -1000 |
Fc-epsilon receptor I signaling in mast cells | 0.0833 | 16 | 1593 | 97 | -0.19 | 0.034 | 1000 | -1000 | -0.078 | -1000 |
Osteopontin-mediated events | 0.0729 | 14 | 561 | 38 | -0.16 | 0.015 | 1000 | -1000 | -0.097 | -1000 |
FOXA2 and FOXA3 transcription factor networks | 0.0729 | 14 | 683 | 46 | -0.42 | 0.018 | 1000 | -1000 | -0.076 | -1000 |
Glucocorticoid receptor regulatory network | 0.0729 | 14 | 1597 | 114 | -0.39 | 0.24 | 1000 | -1000 | -0.065 | -1000 |
JNK signaling in the CD4+ TCR pathway | 0.0677 | 13 | 233 | 17 | -0.068 | 0.012 | 1000 | -1000 | -0.036 | -1000 |
LPA receptor mediated events | 0.0677 | 13 | 1369 | 102 | -0.12 | 0.017 | 1000 | -1000 | -0.081 | -1000 |
Signaling events mediated by Stem cell factor receptor (c-Kit) | 0.0677 | 13 | 1024 | 78 | -0.11 | 0.056 | 1000 | -1000 | -0.068 | -1000 |
Syndecan-2-mediated signaling events | 0.0625 | 12 | 866 | 69 | -0.14 | 0.027 | 1000 | -1000 | -0.033 | -1000 |
Effects of Botulinum toxin | 0.0625 | 12 | 334 | 26 | -0.13 | 0.012 | 1000 | -1000 | -0.052 | -1000 |
Neurotrophic factor-mediated Trk receptor signaling | 0.0625 | 12 | 1550 | 120 | -0.2 | 0.18 | 1000 | -1000 | -0.066 | -1000 |
Caspase cascade in apoptosis | 0.0573 | 11 | 841 | 74 | -0.098 | 0.043 | 1000 | -1000 | -0.044 | -1000 |
Canonical Wnt signaling pathway | 0.0573 | 11 | 578 | 51 | -0.2 | 0.11 | 1000 | -1000 | -0.061 | -1000 |
LPA4-mediated signaling events | 0.0521 | 10 | 120 | 12 | -0.092 | 0.017 | 1000 | -1000 | -0.024 | -1000 |
Lissencephaly gene (LIS1) in neuronal migration and development | 0.0521 | 10 | 580 | 54 | -0.19 | 0.024 | 1000 | -1000 | -0.09 | -1000 |
Cellular roles of Anthrax toxin | 0.0521 | 10 | 422 | 39 | -0.06 | 0.012 | 1000 | -1000 | -0.021 | -1000 |
Arf6 signaling events | 0.0521 | 10 | 659 | 62 | -0.2 | 0.026 | 1000 | -1000 | -0.053 | -1000 |
Signaling events mediated by PTP1B | 0.0521 | 10 | 785 | 76 | -0.2 | 0.026 | 1000 | -1000 | -0.07 | -1000 |
PDGFR-alpha signaling pathway | 0.0521 | 10 | 468 | 44 | -0.073 | 0.02 | 1000 | -1000 | -0.052 | -1000 |
S1P1 pathway | 0.0521 | 10 | 364 | 36 | -0.12 | 0.012 | 1000 | -1000 | -0.054 | -1000 |
TCGA08_p53 | 0.0521 | 10 | 74 | 7 | -0.039 | 0.027 | 1000 | -1000 | -0.014 | -1000 |
Glypican 2 network | 0.0521 | 10 | 40 | 4 | -0.022 | -0.015 | 1000 | -1000 | -0.019 | -1000 |
IL27-mediated signaling events | 0.0521 | 10 | 523 | 51 | -0.2 | 0.033 | 1000 | -1000 | -0.069 | -1000 |
IGF1 pathway | 0.0521 | 10 | 610 | 57 | -0.12 | 0.024 | 1000 | -1000 | -0.08 | -1000 |
Plasma membrane estrogen receptor signaling | 0.0521 | 10 | 900 | 86 | -0.12 | 0.044 | 1000 | -1000 | -0.077 | -1000 |
Ras signaling in the CD4+ TCR pathway | 0.0521 | 10 | 177 | 17 | -0.069 | 0.023 | 1000 | -1000 | -0.045 | -1000 |
Visual signal transduction: Cones | 0.0469 | 9 | 351 | 38 | -0.065 | 0.009 | 1000 | -1000 | -0.058 | -1000 |
a4b1 and a4b7 Integrin signaling | 0.0469 | 9 | 47 | 5 | -0.027 | -0.003 | 1000 | -1000 | -0.018 | -1000 |
Presenilin action in Notch and Wnt signaling | 0.0469 | 9 | 591 | 61 | -0.2 | 0.075 | 1000 | -1000 | -0.063 | -1000 |
IL1-mediated signaling events | 0.0469 | 9 | 611 | 62 | -0.12 | 0.055 | 1000 | -1000 | -0.082 | -1000 |
FAS signaling pathway (CD95) | 0.0469 | 9 | 456 | 47 | -0.21 | 0.022 | 1000 | -1000 | -0.037 | -1000 |
Integrins in angiogenesis | 0.0469 | 9 | 833 | 84 | -0.16 | 0.02 | 1000 | -1000 | -0.083 | -1000 |
Nongenotropic Androgen signaling | 0.0469 | 9 | 502 | 52 | -0.099 | 0.016 | 1000 | -1000 | -0.058 | -1000 |
IL6-mediated signaling events | 0.0469 | 9 | 733 | 75 | -0.14 | 0.052 | 1000 | -1000 | -0.083 | -1000 |
Angiopoietin receptor Tie2-mediated signaling | 0.0469 | 9 | 868 | 88 | -0.17 | 0.039 | 1000 | -1000 | -0.092 | -1000 |
Visual signal transduction: Rods | 0.0469 | 9 | 489 | 52 | -0.13 | 0.012 | 1000 | -1000 | -0.073 | -1000 |
EPHB forward signaling | 0.0417 | 8 | 715 | 85 | -0.12 | 0.068 | 1000 | -1000 | -0.077 | -1000 |
Coregulation of Androgen receptor activity | 0.0365 | 7 | 539 | 76 | -0.2 | 0.037 | 1000 | -1000 | -0.042 | -1000 |
Sphingosine 1-phosphate (S1P) pathway | 0.0365 | 7 | 206 | 28 | -0.099 | 0.018 | 1000 | -1000 | -0.029 | -1000 |
Retinoic acid receptors-mediated signaling | 0.0365 | 7 | 449 | 58 | -0.14 | 0.024 | 1000 | -1000 | -0.065 | -1000 |
IL2 signaling events mediated by STAT5 | 0.0365 | 7 | 167 | 22 | -0.061 | 0.017 | 1000 | -1000 | -0.054 | -1000 |
Class I PI3K signaling events | 0.0365 | 7 | 517 | 73 | -0.13 | 0.031 | 1000 | -1000 | -0.062 | -1000 |
S1P3 pathway | 0.0365 | 7 | 317 | 42 | -0.099 | 0.018 | 1000 | -1000 | -0.04 | -1000 |
S1P4 pathway | 0.0365 | 7 | 179 | 25 | -0.099 | 0.018 | 1000 | -1000 | -0.039 | -1000 |
PLK2 and PLK4 events | 0.0312 | 6 | 18 | 3 | -0.009 | 0.012 | 1000 | -1000 | -0.018 | -1000 |
Nectin adhesion pathway | 0.0312 | 6 | 413 | 63 | -0.038 | 0.019 | 1000 | -1000 | -0.067 | -1000 |
Paxillin-independent events mediated by a4b1 and a4b7 | 0.0312 | 6 | 258 | 37 | -0.14 | 0.018 | 1000 | -1000 | -0.049 | -1000 |
S1P5 pathway | 0.0312 | 6 | 116 | 17 | -0.099 | 0.051 | 1000 | -1000 | -0.032 | -1000 |
RXR and RAR heterodimerization with other nuclear receptor | 0.0312 | 6 | 318 | 52 | -0.14 | 0.038 | 1000 | -1000 | -0.037 | -1000 |
Syndecan-3-mediated signaling events | 0.0312 | 6 | 214 | 35 | -0.11 | 0.036 | 1000 | -1000 | -0.039 | -1000 |
PDGFR-beta signaling pathway | 0.0312 | 6 | 618 | 97 | -0.093 | 0.038 | 1000 | -1000 | -0.071 | -1000 |
FOXM1 transcription factor network | 0.0312 | 6 | 309 | 51 | -0.11 | 0.12 | 1000 | -1000 | -0.18 | -1000 |
Regulation of nuclear SMAD2/3 signaling | 0.0260 | 5 | 704 | 136 | -0.095 | 0.077 | 1000 | -1000 | -0.064 | -1000 |
ErbB4 signaling events | 0.0260 | 5 | 389 | 69 | -0.19 | 0.035 | 1000 | -1000 | -0.081 | -1000 |
IFN-gamma pathway | 0.0260 | 5 | 358 | 68 | -0.084 | 0.024 | 1000 | -1000 | -0.086 | -1000 |
Regulation of p38-alpha and p38-beta | 0.0260 | 5 | 297 | 54 | -0.13 | 0.031 | 1000 | -1000 | -0.061 | -1000 |
Regulation of Telomerase | 0.0260 | 5 | 560 | 102 | -0.24 | 0.041 | 1000 | -1000 | -0.11 | -1000 |
ErbB2/ErbB3 signaling events | 0.0208 | 4 | 307 | 65 | -0.081 | 0.022 | 1000 | -1000 | -0.064 | -1000 |
Hedgehog signaling events mediated by Gli proteins | 0.0208 | 4 | 305 | 65 | -0.098 | 0.038 | 1000 | -1000 | -0.069 | -1000 |
Ceramide signaling pathway | 0.0208 | 4 | 316 | 76 | -0.2 | 0.066 | 1000 | -1000 | -0.045 | -1000 |
Signaling mediated by p38-gamma and p38-delta | 0.0208 | 4 | 67 | 15 | -0.038 | 0.026 | 1000 | -1000 | -0.029 | -1000 |
Signaling events mediated by PRL | 0.0208 | 4 | 161 | 34 | -0.036 | 0.024 | 1000 | -1000 | -0.027 | -1000 |
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) | 0.0156 | 3 | 289 | 85 | -0.058 | 0.032 | 1000 | -1000 | -0.067 | -1000 |
Signaling events mediated by HDAC Class III | 0.0156 | 3 | 128 | 40 | -0.055 | 0.019 | 1000 | -1000 | -0.039 | -1000 |
Role of Calcineurin-dependent NFAT signaling in lymphocytes | 0.0156 | 3 | 293 | 83 | -0.15 | 0.057 | 1000 | -1000 | -0.072 | -1000 |
Paxillin-dependent events mediated by a4b1 | 0.0156 | 3 | 128 | 36 | -0.036 | 0.024 | 1000 | -1000 | -0.066 | -1000 |
IL2 signaling events mediated by PI3K | 0.0156 | 3 | 230 | 58 | -0.061 | 0.032 | 1000 | -1000 | -0.084 | -1000 |
HIV-1 Nef: Negative effector of Fas and TNF-alpha | 0.0156 | 3 | 137 | 45 | -0.086 | 0.047 | 1000 | -1000 | -0.083 | -1000 |
Stabilization and expansion of the E-cadherin adherens junction | 0.0156 | 3 | 254 | 74 | -0.2 | 0.06 | 1000 | -1000 | -0.077 | -1000 |
Insulin Pathway | 0.0156 | 3 | 237 | 74 | -0.17 | 0.031 | 1000 | -1000 | -0.083 | -1000 |
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | 0.0156 | 3 | 131 | 33 | -0.069 | 0.036 | 1000 | -1000 | -0.045 | -1000 |
Class IB PI3K non-lipid kinase events | 0.0156 | 3 | 9 | 3 | -0.002 | 0.002 | 1000 | -1000 | -0.006 | -1000 |
Regulation of Androgen receptor activity | 0.0156 | 3 | 273 | 70 | -0.22 | 0.028 | 1000 | -1000 | -0.06 | -1000 |
Signaling events mediated by HDAC Class II | 0.0104 | 2 | 161 | 75 | -0.064 | 0.029 | 1000 | -1000 | -0.039 | -1000 |
Arf6 downstream pathway | 0.0104 | 2 | 86 | 43 | -0.074 | 0.029 | 1000 | -1000 | -0.03 | -1000 |
Signaling events mediated by VEGFR1 and VEGFR2 | 0.0104 | 2 | 326 | 125 | -0.059 | 0.066 | 1000 | -1000 | -0.089 | -1000 |
TCGA08_rtk_signaling | 0.0104 | 2 | 77 | 26 | -0.067 | 0.036 | 1000 | -1000 | -0.018 | -1000 |
Rapid glucocorticoid signaling | 0.0104 | 2 | 53 | 20 | -0.019 | 0.012 | 1000 | -1000 | -0.019 | -1000 |
Aurora B signaling | 0.0104 | 2 | 154 | 67 | -0.14 | 0.034 | 1000 | -1000 | -0.065 | -1000 |
Canonical NF-kappaB pathway | 0.0052 | 1 | 49 | 39 | -0.025 | 0.064 | 1000 | -1000 | -0.077 | -1000 |
BARD1 signaling events | 0.0052 | 1 | 101 | 57 | -0.032 | 0.06 | 1000 | -1000 | -0.055 | -1000 |
Aurora A signaling | 0.0052 | 1 | 69 | 60 | -0.05 | 0.033 | 1000 | -1000 | -0.046 | -1000 |
Aurora C signaling | 0.0052 | 1 | 11 | 7 | -0.007 | 0.012 | 1000 | -1000 | -0.024 | -1000 |
EPO signaling pathway | 0.0052 | 1 | 89 | 55 | -0.036 | 0.058 | 1000 | -1000 | -0.081 | -1000 |
mTOR signaling pathway | 0.0052 | 1 | 70 | 53 | -0.007 | 0.029 | 1000 | -1000 | -0.053 | -1000 |
TRAIL signaling pathway | 0.0052 | 1 | 59 | 48 | -0.022 | 0.045 | 1000 | -1000 | -0.063 | -1000 |
ceramide signaling pathway | 0.0052 | 1 | 64 | 49 | -0.016 | 0.037 | 1000 | -1000 | -0.051 | -1000 |
HIF-2-alpha transcription factor network | 0.0052 | 1 | 79 | 43 | -0.088 | 0.09 | 1000 | -1000 | -0.084 | -1000 |
Signaling events mediated by HDAC Class I | 0.0052 | 1 | 114 | 104 | -0.024 | 0.05 | 1000 | -1000 | -0.061 | -1000 |
E-cadherin signaling in the nascent adherens junction | 0.0052 | 1 | 128 | 76 | -0.075 | 0.052 | 1000 | -1000 | -0.078 | -1000 |
Arf6 trafficking events | 0.0052 | 1 | 107 | 71 | -0.062 | 0.039 | 1000 | -1000 | -0.067 | -1000 |
VEGFR1 specific signals | 0.0052 | 1 | 109 | 56 | -0.016 | 0.041 | 1000 | -1000 | -0.061 | -1000 |
p38 MAPK signaling pathway | 0.0052 | 1 | 59 | 44 | -0.036 | 0.031 | 1000 | -1000 | -0.063 | -1000 |
Regulation of cytoplasmic and nuclear SMAD2/3 signaling | 0.0000 | 0 | 6 | 23 | 0.009 | 0.039 | 1000 | -1000 | -0.049 | -1000 |
Circadian rhythm pathway | 0.0000 | 0 | 17 | 22 | -0.012 | 0.044 | 1000 | -1000 | -0.042 | -1000 |
PLK1 signaling events | 0.0000 | 0 | 18 | 85 | -0.011 | 0.033 | 1000 | -1000 | -0.037 | -1000 |
Insulin-mediated glucose transport | 0.0000 | 0 | 3 | 32 | -0.006 | 0.039 | 1000 | -1000 | -0.056 | -1000 |
Class I PI3K signaling events mediated by Akt | 0.0000 | 0 | 50 | 68 | -0.037 | 0.051 | 1000 | -1000 | -0.05 | -1000 |
FoxO family signaling | 0.0000 | 0 | 50 | 64 | -0.1 | 0.12 | 1000 | -1000 | -0.072 | -1000 |
Atypical NF-kappaB pathway | 0.0000 | 0 | 28 | 31 | -0.051 | 0.028 | 1000 | -1000 | -0.045 | -1000 |
Sumoylation by RanBP2 regulates transcriptional repression | 0.0000 | 0 | 2 | 27 | -0.001 | 0.031 | 1000 | -1000 | -0.045 | -1000 |
E-cadherin signaling in keratinocytes | 0.0000 | 0 | 5 | 43 | -0.04 | 0.046 | 1000 | -1000 | -0.064 | -1000 |
E-cadherin signaling events | 0.0000 | 0 | 0 | 5 | 0.012 | 0.024 | 1000 | -1000 | -0.029 | -1000 |
Arf1 pathway | 0.0000 | 0 | 37 | 54 | -0.032 | 0.024 | 1000 | -1000 | -0.033 | -1000 |
Alternative NF-kappaB pathway | 0.0000 | 0 | 0 | 13 | 0 | 0.036 | 1000 | -1000 | -0.028 | -1000 |
Total | NA | 1181 | 71364 | 7203 | -17 | 5.5 | 131000 | -131000 | -8 | -131000 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | -0.61 | 0.58 | -10000 | 0 | -1.3 | 69 | 69 |
STAT6 (cleaved dimer) | -0.66 | 0.58 | -10000 | 0 | -1.2 | 84 | 84 |
IGHG1 | -0.18 | 0.17 | -10000 | 0 | -10000 | 0 | 0 |
IGHG3 | -0.59 | 0.56 | -10000 | 0 | -1.2 | 82 | 82 |
AKT1 | -0.26 | 0.28 | -10000 | 0 | -0.7 | 27 | 27 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHP1 | -0.19 | 0.23 | -10000 | 0 | -0.66 | 15 | 15 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/IRS1 | -0.27 | 0.28 | -10000 | 0 | -0.67 | 29 | 29 |
THY1 | -0.62 | 0.6 | -10000 | 0 | -1.3 | 69 | 69 |
MYB | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
HMGA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL4/IL4R/JAK1/IL2R gamma/JAK3 | -0.35 | 0.35 | -10000 | 0 | -0.75 | 57 | 57 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHIP | -0.27 | 0.27 | -10000 | 0 | -0.63 | 36 | 36 |
SP1 | 0.017 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
INPP5D | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
SOCS5 | 0.028 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
STAT6 (dimer)/ETS1 | -0.62 | 0.61 | -10000 | 0 | -1.3 | 74 | 74 |
SOCS1 | -0.37 | 0.36 | -10000 | 0 | -0.78 | 66 | 66 |
SOCS3 | -0.28 | 0.3 | -10000 | 0 | -0.79 | 25 | 25 |
FCER2 | -0.53 | 0.52 | -10000 | 0 | -1.1 | 66 | 66 |
PARP14 | 0.009 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
CCL17 | -0.66 | 0.64 | -10000 | 0 | -1.4 | 72 | 72 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP | -0.22 | 0.22 | -10000 | 0 | -0.58 | 18 | 18 |
T cell proliferation | -0.62 | 0.62 | -10000 | 0 | -1.3 | 70 | 70 |
IL4R/JAK1 | -0.62 | 0.59 | -10000 | 0 | -1.3 | 70 | 70 |
EGR2 | -0.65 | 0.62 | -10000 | 0 | -1.3 | 74 | 74 |
JAK2 | -0.023 | 0.061 | -10000 | 0 | -0.44 | 3 | 3 |
JAK3 | 0.004 | 0.072 | -10000 | 0 | -0.48 | 4 | 4 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
JAK1 | 0.001 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
COL1A2 | -0.25 | 0.39 | -10000 | 0 | -1.4 | 16 | 16 |
CCL26 | -0.69 | 0.63 | -10000 | 0 | -1.4 | 78 | 78 |
IL4R | -0.66 | 0.64 | -10000 | 0 | -1.4 | 69 | 69 |
PTPN6 | 0.025 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
IL13RA2 | -0.68 | 0.64 | -10000 | 0 | -1.3 | 82 | 82 |
IL13RA1 | -0.016 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
IRF4 | -0.31 | 0.54 | -10000 | 0 | -1.3 | 36 | 36 |
ARG1 | -0.16 | 0.19 | -10000 | 0 | -0.81 | 8 | 8 |
CBL | -0.32 | 0.32 | -10000 | 0 | -0.72 | 52 | 52 |
GTF3A | 0.015 | 0.031 | -10000 | 0 | -0.41 | 1 | 1 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL13RA1/JAK2 | -0.026 | 0.057 | -10000 | 0 | -0.32 | 3 | 3 |
IRF4/BCL6 | -0.28 | 0.49 | -10000 | 0 | -1.2 | 34 | 34 |
CD40LG | -0.057 | 0.2 | -10000 | 0 | -0.6 | 22 | 22 |
MAPK14 | -0.32 | 0.33 | -10000 | 0 | -0.75 | 46 | 46 |
mitosis | -0.25 | 0.26 | -10000 | 0 | -0.66 | 26 | 26 |
STAT6 | -0.74 | 0.78 | -10000 | 0 | -1.5 | 80 | 80 |
SPI1 | -0.023 | 0.14 | -10000 | 0 | -0.53 | 13 | 13 |
RPS6KB1 | -0.24 | 0.26 | -10000 | 0 | -0.64 | 25 | 25 |
STAT6 (dimer) | -0.75 | 0.79 | -10000 | 0 | -1.5 | 80 | 80 |
STAT6 (dimer)/PARP14 | -0.68 | 0.66 | -10000 | 0 | -1.3 | 81 | 81 |
mast cell activation | 0.013 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/DOK2 | -0.27 | 0.29 | -10000 | 0 | -0.71 | 30 | 30 |
FRAP1 | -0.26 | 0.28 | -10000 | 0 | -0.7 | 27 | 27 |
LTA | -0.63 | 0.62 | -10000 | 0 | -1.3 | 70 | 70 |
FES | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
T-helper 1 cell differentiation | 0.7 | 0.7 | 1.4 | 80 | -10000 | 0 | 80 |
CCL11 | -0.64 | 0.62 | -10000 | 0 | -1.3 | 72 | 72 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES | -0.26 | 0.28 | -10000 | 0 | -0.68 | 28 | 28 |
IL2RG | 0.007 | 0.064 | -10000 | 0 | -0.49 | 3 | 3 |
IL10 | -0.65 | 0.63 | -10000 | 0 | -1.4 | 73 | 73 |
IRS1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
IRS2 | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
IL4 | -0.13 | 0.12 | -10000 | 0 | -10000 | 0 | 0 |
IL5 | -0.62 | 0.58 | -10000 | 0 | -1.3 | 69 | 69 |
IL4/IL4R/JAK1/IL13RA1/JAK2 | -0.46 | 0.42 | -10000 | 0 | -0.91 | 74 | 74 |
COL1A1 | -0.28 | 0.43 | -10000 | 0 | -1.4 | 20 | 20 |
positive regulation of NF-kappaB transcription factor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL4/IL4R/JAK1 | -0.63 | 0.62 | -10000 | 0 | -1.4 | 68 | 68 |
IL2R gamma/JAK3 | 0.004 | 0.07 | -10000 | 0 | -0.34 | 7 | 7 |
TFF3 | -0.65 | 0.62 | -10000 | 0 | -1.4 | 72 | 72 |
ALOX15 | -0.72 | 0.67 | -10000 | 0 | -1.4 | 81 | 81 |
MYBL1 | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
T-helper 2 cell differentiation | -0.49 | 0.45 | -10000 | 0 | -0.98 | 71 | 71 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CEBPB | 0.014 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/FES/IRS2 | -0.26 | 0.27 | -10000 | 0 | -0.64 | 27 | 27 |
mol:PI-3-4-5-P3 | -0.26 | 0.28 | -10000 | 0 | -0.7 | 27 | 27 |
PI3K | -0.27 | 0.3 | -10000 | 0 | -0.75 | 27 | 27 |
DOK2 | -0.024 | 0.14 | -10000 | 0 | -0.56 | 12 | 12 |
ETS1 | 0.008 | 0.098 | -10000 | 0 | -0.52 | 6 | 6 |
IL4/IL4R/JAK1/IL2R gamma/JAK3/SHC/SHIP/GRB2 | -0.2 | 0.21 | -10000 | 0 | -0.61 | 11 | 11 |
ITGB3 | -0.62 | 0.61 | -10000 | 0 | -1.3 | 69 | 69 |
PIGR | -0.77 | 0.7 | -10000 | 0 | -1.5 | 86 | 86 |
IGHE | 0.047 | 0.043 | 0.3 | 1 | -10000 | 0 | 1 |
MAPKKK cascade | -0.2 | 0.2 | -10000 | 0 | -0.61 | 10 | 10 |
BCL6 | 0.011 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
OPRM1 | -0.62 | 0.58 | -10000 | 0 | -1.3 | 70 | 70 |
RETNLB | -0.77 | 0.68 | -10000 | 0 | -1.4 | 87 | 87 |
SELP | -0.72 | 0.69 | -10000 | 0 | -1.5 | 78 | 78 |
AICDA | -0.6 | 0.56 | -10000 | 0 | -1.2 | 70 | 70 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CCL2 | -0.45 | 0.52 | -10000 | 0 | -1.1 | 55 | 55 |
IL23A | -0.47 | 0.54 | -10000 | 0 | -1.2 | 51 | 51 |
NF kappa B1 p50/RelA/I kappa B alpha | -0.5 | 0.5 | -10000 | 0 | -1.1 | 58 | 58 |
positive regulation of T cell mediated cytotoxicity | -0.51 | 0.62 | -10000 | 0 | -1.3 | 57 | 57 |
ITGA3 | -0.44 | 0.51 | -10000 | 0 | -1.1 | 52 | 52 |
IL17F | -0.31 | 0.34 | -10000 | 0 | -0.72 | 51 | 51 |
IL12B | -0.017 | 0.083 | -10000 | 0 | -0.44 | 6 | 6 |
STAT1 (dimer) | -0.49 | 0.58 | -10000 | 0 | -1.2 | 56 | 56 |
CD4 | -0.45 | 0.53 | -10000 | 0 | -1.1 | 56 | 56 |
IL23 | -0.45 | 0.52 | -10000 | 0 | -1.2 | 50 | 50 |
IL23R | -0.11 | 0.3 | -10000 | 0 | -1.4 | 9 | 9 |
IL1B | -0.49 | 0.57 | -10000 | 0 | -1.2 | 56 | 56 |
T-helper cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL24 | -0.52 | 0.56 | -10000 | 0 | -1.2 | 65 | 65 |
TYK2 | -0.001 | 0.021 | -10000 | 0 | -10000 | 0 | 0 |
STAT4 | -0.046 | 0.18 | -10000 | 0 | -0.58 | 19 | 19 |
STAT3 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
IL18RAP | -0.048 | 0.18 | -10000 | 0 | -0.58 | 19 | 19 |
IL12RB1 | -0.055 | 0.18 | -10000 | 0 | -0.59 | 18 | 18 |
PIK3CA | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
IL12Rbeta1/TYK2 | -0.042 | 0.13 | -10000 | 0 | -0.44 | 18 | 18 |
IL23R/JAK2 | -0.12 | 0.29 | -10000 | 0 | -1.4 | 8 | 8 |
positive regulation of chronic inflammatory response | -0.51 | 0.62 | -10000 | 0 | -1.3 | 57 | 57 |
natural killer cell activation | 0.008 | 0.017 | 0.067 | 11 | -10000 | 0 | 11 |
JAK2 | -0.002 | 0.062 | -10000 | 0 | -0.45 | 3 | 3 |
PIK3R1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.009 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
RELA | 0.009 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of dendritic cell antigen processing and presentation | -0.43 | 0.48 | -10000 | 0 | -1.1 | 52 | 52 |
ALOX12B | -0.51 | 0.56 | -10000 | 0 | -1.2 | 65 | 65 |
CXCL1 | -0.45 | 0.53 | -10000 | 0 | -1.1 | 54 | 54 |
T cell proliferation | -0.51 | 0.62 | -10000 | 0 | -1.3 | 57 | 57 |
NFKBIA | 0.009 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
IL17A | -0.27 | 0.29 | -10000 | 0 | -0.61 | 50 | 50 |
PI3K | -0.5 | 0.5 | -10000 | 0 | -1.1 | 59 | 59 |
IFNG | -0.023 | 0.054 | 0.14 | 6 | -0.11 | 27 | 33 |
STAT3 (dimer) | -0.49 | 0.47 | -10000 | 0 | -1.1 | 61 | 61 |
IL18R1 | -0.022 | 0.13 | -10000 | 0 | -0.56 | 11 | 11 |
IL23/IL23R/JAK2/TYK2/SOCS3 | -0.25 | 0.32 | -10000 | 0 | -0.7 | 39 | 39 |
IL18/IL18R | -0.035 | 0.14 | -10000 | 0 | -0.38 | 26 | 26 |
macrophage activation | -0.024 | 0.018 | -10000 | 0 | -0.044 | 47 | 47 |
TNF | -0.47 | 0.55 | -10000 | 0 | -1.2 | 53 | 53 |
STAT3/STAT4 | -0.52 | 0.52 | -10000 | 0 | -1.1 | 62 | 62 |
STAT4 (dimer) | -0.5 | 0.6 | -10000 | 0 | -1.2 | 59 | 59 |
IL18 | 0.008 | 0.031 | -10000 | 0 | -0.4 | 1 | 1 |
IL19 | -0.44 | 0.5 | -10000 | 0 | -1.1 | 57 | 57 |
STAT5A (dimer) | -0.49 | 0.58 | -10000 | 0 | -1.2 | 55 | 55 |
STAT1 | 0.005 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
SOCS3 | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
CXCL9 | -0.5 | 0.57 | -10000 | 0 | -1.2 | 60 | 60 |
MPO | -0.48 | 0.55 | -10000 | 0 | -1.2 | 57 | 57 |
positive regulation of humoral immune response | -0.51 | 0.62 | -10000 | 0 | -1.3 | 57 | 57 |
IL23/IL23R/JAK2/TYK2 | -0.57 | 0.75 | -10000 | 0 | -1.5 | 57 | 57 |
IL6 | -0.53 | 0.59 | -10000 | 0 | -1.2 | 65 | 65 |
STAT5A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL2 | 0.003 | 0.033 | -10000 | 0 | -0.41 | 1 | 1 |
positive regulation of tyrosine phosphorylation of STAT protein | 0.008 | 0.017 | 0.067 | 11 | -10000 | 0 | 11 |
CD3E | -0.45 | 0.53 | -10000 | 0 | -1.1 | 52 | 52 |
keratinocyte proliferation | -0.51 | 0.62 | -10000 | 0 | -1.3 | 57 | 57 |
NOS2 | -0.53 | 0.58 | -10000 | 0 | -1.2 | 69 | 69 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MAPKKK cascade | -0.072 | 0.16 | -9999 | 0 | -0.34 | 47 | 47 |
EFNA5 | -0.11 | 0.24 | -9999 | 0 | -0.57 | 39 | 39 |
FYN | -0.061 | 0.15 | -9999 | 0 | -0.38 | 29 | 29 |
neuron projection morphogenesis | -0.072 | 0.16 | -9999 | 0 | -0.34 | 47 | 47 |
cell-cell signaling | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ephrin A5/EPHA5 | -0.073 | 0.16 | -9999 | 0 | -0.34 | 47 | 47 |
EPHA5 | -0.012 | 0.09 | -9999 | 0 | -0.42 | 9 | 9 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Noncanonical Wnts/FZD | -0.14 | 0.23 | -9999 | 0 | -0.41 | 60 | 60 |
FZD6 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
WNT6 | -0.1 | 0.22 | -9999 | 0 | -0.49 | 44 | 44 |
WNT4 | -0.077 | 0.21 | -9999 | 0 | -0.55 | 30 | 30 |
FZD3 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
WNT5A | -0.011 | 0.12 | -9999 | 0 | -0.6 | 7 | 7 |
WNT11 | -0.16 | 0.26 | -9999 | 0 | -0.53 | 63 | 63 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PTGS2 | -0.17 | 0.34 | -9999 | 0 | -1.1 | 19 | 19 |
MKNK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | -0.073 | 0.14 | -9999 | 0 | -0.38 | 4 | 4 |
ATF2/c-Jun | -0.043 | 0.12 | -9999 | 0 | -0.84 | 1 | 1 |
MAPK11 | -0.078 | 0.14 | -9999 | 0 | -0.3 | 45 | 45 |
MITF | -0.11 | 0.22 | -9999 | 0 | -0.42 | 51 | 51 |
MAPKAPK5 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
KRT8 | -0.082 | 0.17 | -9999 | 0 | -0.36 | 44 | 44 |
MAPKAPK3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPKAPK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
p38alpha-beta/CK2 | -0.11 | 0.2 | -9999 | 0 | -0.44 | 44 | 44 |
CEBPB | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
SLC9A1 | -0.082 | 0.17 | -9999 | 0 | -0.36 | 44 | 44 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ATF2 | -0.073 | 0.16 | -9999 | 0 | -0.33 | 45 | 45 |
p38alpha-beta/MNK1 | -0.077 | 0.16 | -9999 | 0 | -0.47 | 5 | 5 |
JUN | -0.043 | 0.12 | -9999 | 0 | -0.83 | 1 | 1 |
PPARGC1A | -0.12 | 0.23 | -9999 | 0 | -0.43 | 55 | 55 |
USF1 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
RAB5/GDP/GDI1 | -0.073 | 0.1 | -9999 | 0 | -0.34 | 4 | 4 |
NOS2 | -0.21 | 0.41 | -9999 | 0 | -1 | 34 | 34 |
DDIT3 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
RAB5A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HSPB1 | -0.058 | 0.14 | -9999 | 0 | -0.38 | 5 | 5 |
p38alpha-beta/HBP1 | -0.077 | 0.16 | -9999 | 0 | -0.47 | 5 | 5 |
CREB1 | -0.078 | 0.17 | -9999 | 0 | -0.36 | 44 | 44 |
RAB5/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EIF4E | -0.062 | 0.14 | -9999 | 0 | -0.43 | 4 | 4 |
RPS6KA4 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
PLA2G4A | -0.17 | 0.22 | -9999 | 0 | -0.49 | 45 | 45 |
GDI1 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
TP53 | -0.12 | 0.22 | -9999 | 0 | -0.46 | 45 | 45 |
RPS6KA5 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
ESR1 | -0.12 | 0.23 | -9999 | 0 | -0.44 | 52 | 52 |
HBP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MEF2C | -0.089 | 0.17 | -9999 | 0 | -0.36 | 47 | 47 |
MEF2A | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
EIF4EBP1 | -0.078 | 0.17 | -9999 | 0 | -0.36 | 44 | 44 |
KRT19 | -0.082 | 0.18 | -9999 | 0 | -0.36 | 45 | 45 |
ELK4 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
ATF6 | -0.079 | 0.16 | -9999 | 0 | -0.35 | 44 | 44 |
ATF1 | -0.078 | 0.17 | -9999 | 0 | -0.36 | 44 | 44 |
p38alpha-beta/MAPKAPK2 | -0.077 | 0.16 | -9999 | 0 | -0.49 | 4 | 4 |
p38alpha-beta/MAPKAPK3 | -0.077 | 0.16 | -9999 | 0 | -0.47 | 5 | 5 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
alphaM/beta2 Integrin/proMMP-2 | -0.14 | 0.26 | -9999 | 0 | -0.59 | 37 | 37 |
alphaM/beta2 Integrin/GPIbA | -0.12 | 0.22 | -9999 | 0 | -0.52 | 36 | 36 |
alphaM/beta2 Integrin/proMMP-9 | -0.16 | 0.28 | -9999 | 0 | -0.57 | 48 | 48 |
PLAUR | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
HMGB1 | 0.004 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
alphaM/beta2 Integrin/Talin | -0.1 | 0.21 | -9999 | 0 | -0.52 | 31 | 31 |
AGER | -0.018 | 0.11 | -9999 | 0 | -0.59 | 7 | 7 |
RAP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SELPLG | -0.013 | 0.12 | -9999 | 0 | -0.58 | 8 | 8 |
mol:LDL | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaM/beta2 Integrin/RAGE/HMGB1 | -0.14 | 0.22 | -9999 | 0 | -0.49 | 39 | 39 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MMP9 | -0.089 | 0.22 | -9999 | 0 | -0.56 | 34 | 34 |
CYR61 | -0.026 | 0.13 | -9999 | 0 | -0.47 | 15 | 15 |
TLN1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rap1/GTP | -0.13 | 0.19 | -9999 | 0 | -0.49 | 32 | 32 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
P-selectin oligomer | -0.15 | 0.26 | -9999 | 0 | -0.54 | 56 | 56 |
MYH2 | -0.13 | 0.2 | -9999 | 0 | -0.48 | 36 | 36 |
MST1R | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
leukocyte activation during inflammatory response | -0.12 | 0.2 | -9999 | 0 | -0.49 | 34 | 34 |
APOB | -0.057 | 0.16 | -9999 | 0 | -0.46 | 27 | 27 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
complement component iC3b receptor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MMP2 | -0.047 | 0.18 | -9999 | 0 | -0.56 | 20 | 20 |
JAM3 | 0.003 | 0.061 | -9999 | 0 | -0.42 | 4 | 4 |
GP1BA | -0.016 | 0.12 | -9999 | 0 | -0.5 | 10 | 10 |
alphaM/beta2 Integrin/CTGF | -0.11 | 0.23 | -9999 | 0 | -0.55 | 32 | 32 |
alphaM/beta2 Integrin | -0.15 | 0.23 | -9999 | 0 | -0.47 | 49 | 49 |
JAM3 homodimer | 0.003 | 0.061 | -9999 | 0 | -0.42 | 4 | 4 |
ICAM2 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
ICAM1 | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
phagocytosis triggered by activation of immune response cell surface activating receptor | -0.15 | 0.23 | -9999 | 0 | -0.46 | 50 | 50 |
cell adhesion | -0.12 | 0.22 | -9999 | 0 | -0.52 | 36 | 36 |
NFKB1 | -0.14 | 0.27 | -9999 | 0 | -0.5 | 48 | 48 |
THY1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
RhoA/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Lipoprotein(a) | -0.039 | 0.11 | -9999 | 0 | -0.26 | 34 | 34 |
alphaM/beta2 Integrin/LRP/tPA | -0.091 | 0.22 | -9999 | 0 | -0.51 | 34 | 34 |
IL6 | -0.21 | 0.36 | -9999 | 0 | -0.84 | 39 | 39 |
ITGB2 | -0.059 | 0.18 | -9999 | 0 | -0.53 | 22 | 22 |
elevation of cytosolic calcium ion concentration | -0.1 | 0.2 | -9999 | 0 | -0.5 | 31 | 31 |
alphaM/beta2 Integrin/JAM2/JAM3 | -0.13 | 0.25 | -9999 | 0 | -0.52 | 46 | 46 |
JAM2 | -0.083 | 0.22 | -9999 | 0 | -0.56 | 32 | 32 |
alphaM/beta2 Integrin/ICAM1 | -0.089 | 0.21 | -9999 | 0 | -0.46 | 37 | 37 |
alphaM/beta2 Integrin/uPA/Plg | -0.089 | 0.21 | -9999 | 0 | -0.52 | 30 | 30 |
RhoA/GTP | -0.14 | 0.21 | -9999 | 0 | -0.47 | 41 | 41 |
positive regulation of phagocytosis | -0.16 | 0.25 | -9999 | 0 | -0.61 | 35 | 35 |
Ron/MSP | -0.017 | 0.12 | -9999 | 0 | -0.4 | 16 | 16 |
alphaM/beta2 Integrin/uPAR/uPA | -0.083 | 0.21 | -9999 | 0 | -0.51 | 31 | 31 |
alphaM/beta2 Integrin/uPAR | -0.1 | 0.21 | -9999 | 0 | -0.52 | 32 | 32 |
PLAU | -0.005 | 0.095 | -9999 | 0 | -0.52 | 6 | 6 |
PLAT | -0.009 | 0.11 | -9999 | 0 | -0.57 | 7 | 7 |
actin filament polymerization | -0.13 | 0.19 | -9999 | 0 | -0.46 | 36 | 36 |
MST1 | -0.025 | 0.14 | -9999 | 0 | -0.53 | 13 | 13 |
alphaM/beta2 Integrin/lipoprotein(a) | -0.13 | 0.2 | -9999 | 0 | -0.5 | 34 | 34 |
TNF | -0.14 | 0.29 | -9999 | 0 | -0.83 | 18 | 18 |
RAP1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaM/beta2 Integrin/uPA | -0.11 | 0.22 | -9999 | 0 | -0.54 | 33 | 33 |
fibrinolysis | -0.1 | 0.2 | -9999 | 0 | -0.52 | 30 | 30 |
HCK | -0.041 | 0.17 | -9999 | 0 | -0.58 | 17 | 17 |
dendritic cell antigen processing and presentation | -0.15 | 0.23 | -9999 | 0 | -0.46 | 50 | 50 |
VTN | -0.064 | 0.18 | -9999 | 0 | -0.48 | 29 | 29 |
alphaM/beta2 Integrin/CYR61 | -0.12 | 0.23 | -9999 | 0 | -0.56 | 34 | 34 |
LPA | -0.009 | 0.079 | -9999 | 0 | -0.42 | 7 | 7 |
LRP1 | 0 | 0.086 | -9999 | 0 | -0.58 | 4 | 4 |
cell migration | -0.16 | 0.31 | -9999 | 0 | -0.6 | 50 | 50 |
FN1 | -0.1 | 0.23 | -9999 | 0 | -0.54 | 40 | 40 |
alphaM/beta2 Integrin/Thy1 | -0.11 | 0.23 | -9999 | 0 | -0.55 | 34 | 34 |
MPO | -0.063 | 0.2 | -9999 | 0 | -0.56 | 25 | 25 |
KNG1 | -0.097 | 0.21 | -9999 | 0 | -0.48 | 41 | 41 |
RAP1/GDP | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ROCK1 | -0.12 | 0.2 | -9999 | 0 | -0.46 | 37 | 37 |
ELA2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLG | -0.001 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
CTGF | -0.009 | 0.1 | -9999 | 0 | -0.5 | 8 | 8 |
alphaM/beta2 Integrin/Hck | -0.13 | 0.27 | -9999 | 0 | -0.62 | 35 | 35 |
ITGAM | -0.099 | 0.21 | -9999 | 0 | -0.52 | 37 | 37 |
alphaM/beta2 Integrin/P-Selectin/PSGL1 | -0.18 | 0.29 | -9999 | 0 | -0.54 | 57 | 57 |
HP | -0.072 | 0.17 | -9999 | 0 | -0.43 | 36 | 36 |
leukocyte adhesion | -0.17 | 0.25 | -9999 | 0 | -0.68 | 28 | 28 |
SELP | -0.15 | 0.26 | -9999 | 0 | -0.55 | 56 | 56 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NFATC2 | -0.069 | 0.21 | -9999 | 0 | -0.61 | 25 | 25 |
GNB1/GNG2 | -0.12 | 0.21 | -9999 | 0 | -0.5 | 30 | 30 |
mol:DAG | -0.1 | 0.19 | -9999 | 0 | -0.45 | 30 | 30 |
PLCG1 | -0.11 | 0.2 | -9999 | 0 | -0.47 | 30 | 30 |
YES1 | -0.13 | 0.21 | -9999 | 0 | -0.53 | 28 | 28 |
FZD3 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
FZD6 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
G protein | -0.11 | 0.2 | -9999 | 0 | -0.47 | 30 | 30 |
MAP3K7 | -0.1 | 0.18 | -9999 | 0 | -0.48 | 22 | 22 |
mol:Ca2+ | -0.1 | 0.18 | -9999 | 0 | -0.43 | 30 | 30 |
mol:IP3 | -0.1 | 0.19 | -9999 | 0 | -0.45 | 30 | 30 |
NLK | -0.006 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
GNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CAMK2A | -0.12 | 0.19 | -9999 | 0 | -0.49 | 26 | 26 |
MAP3K7IP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Noncanonical Wnts/FZD | -0.14 | 0.23 | -9999 | 0 | -0.41 | 60 | 60 |
CSNK1A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAS | -0.13 | 0.21 | -9999 | 0 | -0.53 | 28 | 28 |
GO:0007205 | -0.1 | 0.19 | -9999 | 0 | -0.44 | 30 | 30 |
WNT6 | -0.1 | 0.22 | -9999 | 0 | -0.49 | 44 | 44 |
WNT4 | -0.077 | 0.21 | -9999 | 0 | -0.55 | 30 | 30 |
NFAT1/CK1 alpha | -0.14 | 0.22 | -9999 | 0 | -0.57 | 26 | 26 |
GNG2 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
WNT5A | -0.011 | 0.12 | -9999 | 0 | -0.6 | 7 | 7 |
WNT11 | -0.16 | 0.26 | -9999 | 0 | -0.53 | 63 | 63 |
CDC42 | -0.11 | 0.2 | -9999 | 0 | -0.49 | 28 | 28 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
JUN | -0.085 | 0.18 | -10000 | 0 | -0.42 | 34 | 34 |
IKBKB | -0.044 | 0.099 | -10000 | 0 | -0.26 | 15 | 15 |
AKT1 | -0.071 | 0.12 | -10000 | 0 | -0.25 | 43 | 43 |
IKBKG | -0.044 | 0.1 | -10000 | 0 | -0.28 | 15 | 15 |
CALM1 | -0.076 | 0.2 | 0.25 | 5 | -0.52 | 24 | 29 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K1 | -0.14 | 0.26 | -10000 | 0 | -0.6 | 38 | 38 |
MAP3K7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.087 | 0.21 | 0.26 | 5 | -0.55 | 25 | 30 |
DOK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AP-1 | -0.037 | 0.11 | 0.21 | 5 | -0.27 | 22 | 27 |
LYN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BLNK | -0.012 | 0.12 | -10000 | 0 | -0.63 | 7 | 7 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BCR complex | -0.14 | 0.25 | -10000 | 0 | -0.5 | 58 | 58 |
CD22 | -0.21 | 0.33 | -10000 | 0 | -0.62 | 57 | 57 |
CAMK2G | -0.064 | 0.18 | 0.25 | 5 | -0.52 | 20 | 25 |
CSNK2A1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
INPP5D | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
SHC/GRB2/SOS1 | -0.1 | 0.17 | -10000 | 0 | -0.46 | 20 | 20 |
GO:0007205 | -0.089 | 0.22 | 0.26 | 5 | -0.56 | 25 | 30 |
SYK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ELK1 | -0.077 | 0.2 | 0.25 | 5 | -0.53 | 24 | 29 |
NFATC1 | -0.15 | 0.25 | -10000 | 0 | -0.52 | 47 | 47 |
B-cell antigen/BCR complex | -0.14 | 0.25 | -10000 | 0 | -0.5 | 58 | 58 |
PAG1/CSK | 0.011 | 0.054 | -10000 | 0 | -0.4 | 3 | 3 |
NFKBIB | -0.006 | 0.034 | 0.089 | 2 | -10000 | 0 | 2 |
HRAS | -0.07 | 0.19 | 0.23 | 5 | -0.48 | 24 | 29 |
NFKBIA | -0.005 | 0.034 | 0.089 | 2 | -10000 | 0 | 2 |
NF-kappa-B/RelA/I kappa B beta | 0.002 | 0.028 | 0.09 | 2 | -10000 | 0 | 2 |
RasGAP/Csk | -0.14 | 0.25 | -10000 | 0 | -0.46 | 61 | 61 |
mol:GDP | -0.082 | 0.2 | 0.27 | 5 | -0.54 | 24 | 29 |
PTEN | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
CD79B | -0.046 | 0.16 | -10000 | 0 | -0.5 | 22 | 22 |
NF-kappa-B/RelA/I kappa B alpha | 0.002 | 0.028 | 0.09 | 2 | -10000 | 0 | 2 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K/BCAP/CD19 | -0.16 | 0.24 | -10000 | 0 | -0.5 | 53 | 53 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:IP3 | -0.09 | 0.22 | 0.26 | 5 | -0.57 | 25 | 30 |
CSK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.083 | 0.2 | 0.25 | 5 | -0.51 | 26 | 31 |
CHUK | -0.044 | 0.1 | -10000 | 0 | -0.28 | 15 | 15 |
IBTK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CARD11/BCL10/MALT1/TAK1 | -0.13 | 0.2 | -10000 | 0 | -0.5 | 35 | 35 |
PTPN6 | -0.17 | 0.31 | -10000 | 0 | -0.66 | 43 | 43 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BCL2A1 | -0.002 | 0.036 | -10000 | 0 | -0.12 | 11 | 11 |
VAV2 | -0.21 | 0.32 | -10000 | 0 | -0.68 | 47 | 47 |
ubiquitin-dependent protein catabolic process | -0.002 | 0.033 | 0.092 | 2 | -10000 | 0 | 2 |
BTK | -0.081 | 0.31 | 0.38 | 7 | -1.1 | 15 | 22 |
CD19 | -0.23 | 0.33 | -10000 | 0 | -0.58 | 69 | 69 |
MAP4K1 | -0.065 | 0.2 | -10000 | 0 | -0.58 | 25 | 25 |
CD72 | -0.024 | 0.13 | -10000 | 0 | -0.48 | 14 | 14 |
PAG1 | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
MAPK14 | -0.11 | 0.22 | -10000 | 0 | -0.5 | 37 | 37 |
SH3BP5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3AP1 | -0.093 | 0.23 | -10000 | 0 | -0.55 | 28 | 28 |
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 | -0.12 | 0.29 | -10000 | 0 | -0.56 | 44 | 44 |
RAF1 | -0.059 | 0.18 | 0.23 | 5 | -0.53 | 16 | 21 |
RasGAP/p62DOK/SHIP | -0.17 | 0.23 | -10000 | 0 | -0.44 | 66 | 66 |
CD79A | -0.15 | 0.26 | -10000 | 0 | -0.56 | 54 | 54 |
re-entry into mitotic cell cycle | -0.038 | 0.11 | 0.21 | 5 | -0.27 | 22 | 27 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK3 | -0.036 | 0.15 | 0.22 | 5 | -0.43 | 16 | 21 |
MAPK1 | -0.036 | 0.15 | 0.22 | 5 | -0.44 | 15 | 20 |
CD72/SHP1 | -0.17 | 0.3 | -10000 | 0 | -0.68 | 39 | 39 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | -0.11 | 0.22 | -10000 | 0 | -0.49 | 38 | 38 |
actin cytoskeleton organization | -0.16 | 0.26 | -10000 | 0 | -0.56 | 46 | 46 |
NF-kappa-B/RelA | 0.008 | 0.054 | 0.18 | 2 | -10000 | 0 | 2 |
Calcineurin | -0.078 | 0.15 | -10000 | 0 | -0.5 | 17 | 17 |
PI3K | -0.18 | 0.22 | -10000 | 0 | -0.53 | 47 | 47 |
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 | -0.094 | 0.22 | -10000 | 0 | -0.58 | 25 | 25 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Bam32/HPK1 | -0.17 | 0.35 | -10000 | 0 | -0.86 | 34 | 34 |
DAPP1 | -0.19 | 0.37 | -10000 | 0 | -1.1 | 23 | 23 |
cytokine secretion | -0.13 | 0.23 | -10000 | 0 | -0.47 | 47 | 47 |
mol:DAG | -0.09 | 0.22 | 0.26 | 5 | -0.57 | 25 | 30 |
PLCG2 | -0.036 | 0.16 | -10000 | 0 | -0.57 | 16 | 16 |
MAP2K1 | -0.048 | 0.16 | 0.23 | 5 | -0.48 | 16 | 21 |
B-cell antigen/BCR complex/FcgammaRIIB | -0.18 | 0.28 | -10000 | 0 | -0.54 | 61 | 61 |
mol:PI-3-4-5-P3 | -0.13 | 0.15 | -10000 | 0 | -0.36 | 46 | 46 |
ETS1 | -0.059 | 0.18 | 0.24 | 5 | -0.49 | 22 | 27 |
B-cell antigen/BCR complex/LYN/SYK/BLNK | -0.095 | 0.21 | -10000 | 0 | -0.4 | 53 | 53 |
B-cell antigen/BCR complex/LYN | -0.16 | 0.29 | -10000 | 0 | -0.55 | 51 | 51 |
MALT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRAF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | -0.18 | 0.28 | -10000 | 0 | -0.61 | 46 | 46 |
B-cell antigen/BCR complex/LYN/SYK | -0.19 | 0.29 | -10000 | 0 | -0.66 | 44 | 44 |
CARD11 | -0.14 | 0.26 | 0.25 | 4 | -0.56 | 43 | 47 |
FCGR2B | -0.11 | 0.23 | -10000 | 0 | -0.54 | 41 | 41 |
PPP3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BCL10 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IKK complex | -0.012 | 0.042 | 0.097 | 2 | -10000 | 0 | 2 |
PTPRC | -0.061 | 0.2 | -10000 | 0 | -0.57 | 24 | 24 |
PDPK1 | -0.072 | 0.11 | -10000 | 0 | -0.24 | 43 | 43 |
PPP3CB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PPP3CC | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
POU2F2 | 0.001 | 0.032 | -10000 | 0 | -0.12 | 5 | 5 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TGFB1 | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
CCL5 | -0.057 | 0.19 | -9999 | 0 | -0.54 | 24 | 24 |
SDCBP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FGFR/FGF2/Syndecan-1 | -0.15 | 0.23 | -9999 | 0 | -0.58 | 30 | 30 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RP11-540L11.1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-1/Laminin-5 | -0.16 | 0.24 | -9999 | 0 | -0.56 | 39 | 39 |
Syndecan-1/Syntenin | -0.14 | 0.22 | -9999 | 0 | -0.56 | 29 | 29 |
MAPK3 | -0.11 | 0.2 | -9999 | 0 | -0.55 | 23 | 23 |
HGF/MET | -0.034 | 0.14 | -9999 | 0 | -0.41 | 23 | 23 |
TGFB1/TGF beta receptor Type II | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
BSG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
keratinocyte migration | -0.16 | 0.24 | -9999 | 0 | -0.55 | 39 | 39 |
Syndecan-1/RANTES | -0.17 | 0.25 | -9999 | 0 | -0.56 | 42 | 42 |
Syndecan-1/CD147 | -0.12 | 0.21 | -9999 | 0 | -0.55 | 27 | 27 |
Syndecan-1/Syntenin/PIP2 | -0.13 | 0.21 | -9999 | 0 | -0.54 | 29 | 29 |
LAMA5 | -0.035 | 0.17 | -9999 | 0 | -0.64 | 14 | 14 |
positive regulation of cell-cell adhesion | -0.14 | 0.19 | -9999 | 0 | -0.53 | 29 | 29 |
MMP7 | -0.14 | 0.25 | -9999 | 0 | -0.53 | 55 | 55 |
HGF | -0.058 | 0.19 | -9999 | 0 | -0.57 | 23 | 23 |
Syndecan-1/CASK | -0.14 | 0.22 | -9999 | 0 | -0.56 | 30 | 30 |
Syndecan-1/HGF/MET | -0.16 | 0.26 | -9999 | 0 | -0.66 | 30 | 30 |
regulation of cell adhesion | -0.1 | 0.2 | -9999 | 0 | -0.53 | 23 | 23 |
HPSE | -0.01 | 0.11 | -9999 | 0 | -0.52 | 8 | 8 |
positive regulation of cell migration | -0.15 | 0.23 | -9999 | 0 | -0.58 | 30 | 30 |
SDC1 | -0.15 | 0.23 | -9999 | 0 | -0.59 | 30 | 30 |
Syndecan-1/Collagen | -0.15 | 0.23 | -9999 | 0 | -0.58 | 30 | 30 |
PPIB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MET | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MMP9 | -0.089 | 0.22 | -9999 | 0 | -0.56 | 34 | 34 |
MAPK1 | -0.11 | 0.2 | -9999 | 0 | -0.55 | 23 | 23 |
homophilic cell adhesion | -0.15 | 0.23 | -9999 | 0 | -0.57 | 30 | 30 |
MMP1 | -0.16 | 0.26 | -9999 | 0 | -0.52 | 63 | 63 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GPC1/FGF2 dimer/FGFR1 dimer | -0.039 | 0.17 | -10000 | 0 | -0.5 | 18 | 18 |
fibroblast growth factor receptor signaling pathway | -0.038 | 0.17 | -10000 | 0 | -0.5 | 18 | 18 |
LAMA1 | -0.063 | 0.2 | -10000 | 0 | -0.56 | 25 | 25 |
PRNP | -0.004 | 0.097 | -10000 | 0 | -0.59 | 5 | 5 |
GPC1/SLIT2 | -0.14 | 0.22 | -10000 | 0 | -0.41 | 71 | 71 |
SMAD2 | 0.014 | 0.072 | -10000 | 0 | -0.35 | 6 | 6 |
GPC1/PrPc/Cu2+ | -0.005 | 0.088 | -10000 | 0 | -0.36 | 11 | 11 |
GPC1/Laminin alpha1 | -0.05 | 0.17 | -10000 | 0 | -0.43 | 29 | 29 |
TDGF1 | -0.097 | 0.24 | -10000 | 0 | -0.62 | 33 | 33 |
CRIPTO/GPC1 | -0.077 | 0.19 | -10000 | 0 | -0.45 | 39 | 39 |
APP/GPC1 | 0.005 | 0.075 | -10000 | 0 | -0.4 | 6 | 6 |
mol:NO | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YES1 | -0.057 | 0.16 | -10000 | 0 | -0.39 | 35 | 35 |
FLT1 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
GPC1/TGFB/TGFBR1/TGFBR2 | 0.01 | 0.073 | -10000 | 0 | -0.39 | 5 | 5 |
SERPINC1 | 0.003 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
FYN | -0.06 | 0.17 | -10000 | 0 | -0.4 | 36 | 36 |
FGR | -0.089 | 0.19 | -10000 | 0 | -0.41 | 46 | 46 |
positive regulation of MAPKKK cascade | -0.13 | 0.23 | -10000 | 0 | -0.49 | 50 | 50 |
SLIT2 | -0.18 | 0.27 | -10000 | 0 | -0.54 | 68 | 68 |
GPC1/NRG | -0.063 | 0.18 | -10000 | 0 | -0.41 | 36 | 36 |
NRG1 | -0.081 | 0.21 | -10000 | 0 | -0.55 | 32 | 32 |
GPC1/VEGF165 homodimer/VEGFR1 homodimer | 0.009 | 0.085 | -10000 | 0 | -0.47 | 5 | 5 |
LYN | -0.057 | 0.16 | -10000 | 0 | -0.39 | 35 | 35 |
mol:Spermine | -0.003 | 0.075 | -10000 | 0 | -0.41 | 6 | 6 |
cell growth | -0.038 | 0.17 | -10000 | 0 | -0.5 | 18 | 18 |
BMP signaling pathway | 0.006 | 0.1 | 0.56 | 6 | -10000 | 0 | 6 |
SRC | -0.057 | 0.16 | -10000 | 0 | -0.39 | 35 | 35 |
TGFBR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Cu2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLA2G2A | -0.21 | 0.28 | -10000 | 0 | -0.55 | 76 | 76 |
GPC1 | -0.006 | 0.1 | -10000 | 0 | -0.56 | 6 | 6 |
TGFBR1 (dimer) | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VEGFA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BLK | -0.14 | 0.21 | -10000 | 0 | -0.44 | 51 | 51 |
HCK | -0.089 | 0.2 | -10000 | 0 | -0.43 | 44 | 44 |
FGF2 | -0.036 | 0.16 | -10000 | 0 | -0.53 | 17 | 17 |
FGFR1 | -0.025 | 0.14 | -10000 | 0 | -0.53 | 13 | 13 |
VEGFR1 homodimer | 0.005 | 0.066 | -10000 | 0 | -0.63 | 2 | 2 |
TGFBR2 | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
cell death | 0.005 | 0.075 | -10000 | 0 | -0.4 | 6 | 6 |
ATIII/GPC1 | -0.002 | 0.081 | -10000 | 0 | -0.38 | 8 | 8 |
PLA2G2A/GPC1 | -0.16 | 0.22 | -10000 | 0 | -0.41 | 78 | 78 |
LCK | -0.093 | 0.2 | -10000 | 0 | -0.46 | 41 | 41 |
neuron differentiation | -0.063 | 0.18 | -10000 | 0 | -0.41 | 36 | 36 |
PrPc/Cu2+ | -0.003 | 0.072 | -10000 | 0 | -0.44 | 5 | 5 |
APP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TGFBR2 (dimer) | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NFATC1 | -0.031 | 0.1 | -9999 | 0 | -0.37 | 14 | 14 |
NFATC2 | -0.06 | 0.15 | -9999 | 0 | -0.44 | 23 | 23 |
NFATC3 | -0.005 | 0.033 | -9999 | 0 | -10000 | 0 | 0 |
CD40LG | -0.25 | 0.35 | -9999 | 0 | -0.67 | 61 | 61 |
PTGS2 | -0.26 | 0.35 | -9999 | 0 | -0.66 | 69 | 69 |
JUNB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/Calcineurin A alpha-beta B1 | -0.011 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
CaM/Ca2+ | -0.011 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
CALM1 | 0.005 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
JUN | 0.002 | 0.048 | -9999 | 0 | -0.65 | 1 | 1 |
mol:Ca2+ | -0.011 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
Calcineurin A alpha-beta B1/FKBP12/FK506 | 0 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
FOSL1 | -0.037 | 0.16 | -9999 | 0 | -0.51 | 18 | 18 |
CREM | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Jun/NFAT1-c-4/p21SNFT | -0.17 | 0.21 | -9999 | 0 | -0.53 | 39 | 39 |
FOS | -0.033 | 0.15 | -9999 | 0 | -0.56 | 13 | 13 |
IFNG | -0.26 | 0.35 | -9999 | 0 | -0.66 | 71 | 71 |
AP-1/NFAT1-c-4 | -0.27 | 0.38 | -9999 | 0 | -0.72 | 63 | 63 |
FASLG | -0.25 | 0.35 | -9999 | 0 | -0.69 | 60 | 60 |
NFAT1-c-4/ICER1 | -0.1 | 0.17 | -9999 | 0 | -0.44 | 29 | 29 |
IL2RA | -0.25 | 0.35 | -9999 | 0 | -0.69 | 58 | 58 |
FKBP12/FK506 | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSF2 | -0.28 | 0.36 | -9999 | 0 | -0.66 | 76 | 76 |
JunB/Fra1/NFAT1-c-4 | -0.13 | 0.16 | -9999 | 0 | -0.43 | 36 | 36 |
IL4 | -0.22 | 0.31 | -9999 | 0 | -0.62 | 55 | 55 |
IL2 | -0.007 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
IL3 | -0.034 | 0.09 | -9999 | 0 | -0.86 | 2 | 2 |
FKBP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BATF3 | -0.017 | 0.12 | -9999 | 0 | -0.5 | 11 | 11 |
mol:FK506 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
POU2F1 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
IL12/IL12R/TYK2/JAK2/SOCS1 | -0.056 | 0.19 | -10000 | 0 | -0.49 | 21 | 21 |
TBX21 | -0.26 | 0.54 | -10000 | 0 | -1.1 | 44 | 44 |
B2M | 0.008 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
TYK2 | 0.009 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
IL12RB1 | -0.046 | 0.18 | -10000 | 0 | -0.59 | 18 | 18 |
GADD45B | -0.16 | 0.39 | -10000 | 0 | -0.84 | 33 | 33 |
IL12RB2 | -0.03 | 0.14 | -10000 | 0 | -0.49 | 16 | 16 |
GADD45G | -0.17 | 0.38 | -10000 | 0 | -0.81 | 37 | 37 |
natural killer cell activation | -0.004 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
RELB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL18 | 0.009 | 0.032 | -10000 | 0 | -0.42 | 1 | 1 |
IL2RA | -0.061 | 0.19 | -10000 | 0 | -0.55 | 25 | 25 |
IFNG | -0.086 | 0.21 | -10000 | 0 | -0.52 | 35 | 35 |
STAT3 (dimer) | -0.17 | 0.38 | -10000 | 0 | -0.77 | 43 | 43 |
HLA-DRB5 | -0.082 | 0.21 | -10000 | 0 | -0.52 | 34 | 34 |
FASLG | -0.26 | 0.54 | -10000 | 0 | -1.1 | 46 | 46 |
NF kappa B2 p52/RelB | -0.28 | 0.42 | -10000 | 0 | -0.91 | 48 | 48 |
CD4 | -0.032 | 0.16 | -10000 | 0 | -0.59 | 14 | 14 |
SOCS1 | 0 | 0.086 | -10000 | 0 | -0.58 | 4 | 4 |
EntrezGene:6955 | -0.005 | 0.015 | -10000 | 0 | -10000 | 0 | 0 |
CD3D | -0.032 | 0.15 | -10000 | 0 | -0.59 | 13 | 13 |
CD3E | -0.037 | 0.16 | -10000 | 0 | -0.58 | 15 | 15 |
CD3G | -0.075 | 0.22 | -10000 | 0 | -0.61 | 26 | 26 |
IL12Rbeta2/JAK2 | -0.019 | 0.12 | -10000 | 0 | -0.38 | 18 | 18 |
CCL3 | -0.24 | 0.52 | -10000 | 0 | -1.1 | 41 | 41 |
CCL4 | -0.24 | 0.52 | -10000 | 0 | -1.1 | 38 | 38 |
HLA-A | 0.003 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
IL18/IL18R | -0.024 | 0.15 | -10000 | 0 | -0.38 | 27 | 27 |
NOS2 | -0.31 | 0.58 | -10000 | 0 | -1.2 | 50 | 50 |
IL12/IL12R/TYK2/JAK2/SPHK2 | -0.049 | 0.18 | -10000 | 0 | -0.45 | 20 | 20 |
IL1R1 | -0.24 | 0.49 | -10000 | 0 | -1 | 43 | 43 |
IL4 | 0.005 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
JAK2 | 0.002 | 0.062 | -10000 | 0 | -0.45 | 3 | 3 |
EntrezGene:6957 | -0.005 | 0.015 | -10000 | 0 | -10000 | 0 | 0 |
TCR/CD3/MHC I/CD8 | -0.21 | 0.48 | -10000 | 0 | -1.1 | 39 | 39 |
RAB7A | -0.12 | 0.32 | -10000 | 0 | -0.76 | 21 | 21 |
lysosomal transport | -0.11 | 0.31 | -10000 | 0 | -0.72 | 21 | 21 |
FOS | -0.18 | 0.42 | -10000 | 0 | -1 | 31 | 31 |
STAT4 (dimer) | -0.18 | 0.44 | -10000 | 0 | -0.89 | 42 | 42 |
STAT5A (dimer) | -0.32 | 0.44 | -10000 | 0 | -0.92 | 55 | 55 |
GZMA | -0.24 | 0.51 | -10000 | 0 | -1.1 | 42 | 42 |
GZMB | -0.28 | 0.54 | -10000 | 0 | -1.1 | 49 | 49 |
HLX | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
LCK | -0.27 | 0.54 | -10000 | 0 | -1.1 | 48 | 48 |
TCR/CD3/MHC II/CD4 | -0.15 | 0.39 | -10000 | 0 | -0.83 | 34 | 34 |
IL2/IL2R | -0.05 | 0.19 | -10000 | 0 | -0.53 | 22 | 22 |
MAPK14 | -0.16 | 0.4 | -10000 | 0 | -0.81 | 39 | 39 |
CCR5 | -0.2 | 0.46 | -10000 | 0 | -0.92 | 43 | 43 |
IL1B | -0.07 | 0.2 | -10000 | 0 | -0.52 | 29 | 29 |
STAT6 | -0.039 | 0.13 | 0.21 | 2 | -0.24 | 27 | 29 |
STAT4 | -0.046 | 0.18 | -10000 | 0 | -0.58 | 19 | 19 |
STAT3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 | 0.005 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFKB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL12B | -0.007 | 0.082 | -10000 | 0 | -0.44 | 6 | 6 |
CD8A | -0.071 | 0.2 | -10000 | 0 | -0.57 | 27 | 27 |
CD8B | -0.065 | 0.19 | -10000 | 0 | -0.55 | 25 | 25 |
T-helper 1 cell differentiation | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
natural killer cell mediated cytotoxicity | 0.055 | 0.18 | 0.48 | 21 | -10000 | 0 | 21 |
IL2RB | -0.041 | 0.17 | -10000 | 0 | -0.55 | 18 | 18 |
proteasomal ubiquitin-dependent protein catabolic process | -0.16 | 0.39 | -10000 | 0 | -0.8 | 42 | 42 |
IL2RG | 0.004 | 0.063 | -10000 | 0 | -0.49 | 3 | 3 |
IL12 | -0.04 | 0.15 | -10000 | 0 | -0.42 | 24 | 24 |
STAT5A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CD247 | -0.036 | 0.16 | -10000 | 0 | -0.57 | 15 | 15 |
IL2 | 0.001 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
SPHK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRAP1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL12A | -0.051 | 0.18 | -10000 | 0 | -0.59 | 19 | 19 |
IL12/IL12R/TYK2/JAK2 | -0.28 | 0.61 | -10000 | 0 | -1.1 | 48 | 48 |
MAP2K3 | -0.17 | 0.4 | -10000 | 0 | -0.8 | 41 | 41 |
RIPK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K6 | -0.17 | 0.4 | -10000 | 0 | -0.8 | 42 | 42 |
regulation of dendritic cell antigen processing and presentation | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HLA-DRA | -0.063 | 0.19 | -10000 | 0 | -0.54 | 26 | 26 |
IL18RAP | -0.047 | 0.18 | -10000 | 0 | -0.58 | 19 | 19 |
IL12Rbeta1/TYK2 | -0.028 | 0.14 | -10000 | 0 | -0.44 | 18 | 18 |
EOMES | -0.17 | 0.44 | -10000 | 0 | -1.3 | 23 | 23 |
STAT1 (dimer) | -0.2 | 0.4 | -10000 | 0 | -0.78 | 50 | 50 |
T cell proliferation | -0.13 | 0.32 | -10000 | 0 | -0.64 | 40 | 40 |
T-helper 1 cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL18R1 | -0.021 | 0.14 | -10000 | 0 | -0.56 | 11 | 11 |
CD8-positive alpha-beta T cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA | -0.21 | 0.29 | -10000 | 0 | -0.7 | 42 | 42 |
ATF2 | -0.14 | 0.36 | -10000 | 0 | -0.75 | 37 | 37 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TGFB2 | -0.071 | 0.24 | -10000 | 0 | -0.67 | 19 | 19 |
IHH | -0.063 | 0.21 | -10000 | 0 | -0.68 | 19 | 19 |
SHH Np/Cholesterol/GAS1 | -0.079 | 0.16 | -10000 | 0 | -0.38 | 37 | 37 |
LRPAP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
dorsoventral neural tube patterning | 0.079 | 0.16 | 0.38 | 37 | -10000 | 0 | 37 |
SMO/beta Arrestin2 | -0.065 | 0.23 | -10000 | 0 | -0.69 | 16 | 16 |
SMO | -0.075 | 0.25 | -10000 | 0 | -0.59 | 27 | 27 |
AKT1 | -0.011 | 0.1 | -10000 | 0 | -0.31 | 7 | 7 |
ARRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BOC | -0.072 | 0.2 | -10000 | 0 | -0.51 | 31 | 31 |
ADRBK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
heart looping | -0.073 | 0.24 | -10000 | 0 | -0.58 | 27 | 27 |
STIL | -0.036 | 0.18 | -10000 | 0 | -0.59 | 12 | 12 |
DHH N/PTCH2 | -0.076 | 0.21 | -10000 | 0 | -0.47 | 37 | 37 |
DHH N/PTCH1 | -0.078 | 0.21 | -10000 | 0 | -0.48 | 25 | 25 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DHH | -0.053 | 0.19 | -10000 | 0 | -0.58 | 21 | 21 |
PTHLH | -0.099 | 0.31 | -10000 | 0 | -0.91 | 19 | 19 |
determination of left/right symmetry | -0.073 | 0.24 | -10000 | 0 | -0.58 | 27 | 27 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
skeletal system development | -0.098 | 0.31 | -10000 | 0 | -0.9 | 19 | 19 |
IHH N/Hhip | -0.14 | 0.25 | -10000 | 0 | -0.47 | 62 | 62 |
DHH N/Hhip | -0.14 | 0.23 | -10000 | 0 | -0.44 | 64 | 64 |
mol:Cholesterol | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
heart development | -0.073 | 0.24 | -10000 | 0 | -0.58 | 27 | 27 |
pancreas development | -0.13 | 0.25 | -10000 | 0 | -0.55 | 50 | 50 |
HHAT | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
PI3K | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EntrezGene:84976 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GAS1 | -0.13 | 0.25 | -10000 | 0 | -0.54 | 50 | 50 |
somite specification | -0.073 | 0.24 | -10000 | 0 | -0.58 | 27 | 27 |
SHH Np/Cholesterol/PTCH1 | -0.045 | 0.19 | -10000 | 0 | -0.6 | 13 | 13 |
SHH Np/Cholesterol/PTCH2 | -0.035 | 0.13 | -10000 | 0 | -0.37 | 22 | 22 |
SHH Np/Cholesterol/Megalin | -0.021 | 0.1 | -10000 | 0 | -0.41 | 9 | 9 |
SHH | -0.004 | 0.1 | -10000 | 0 | -0.45 | 10 | 10 |
catabolic process | -0.052 | 0.19 | -10000 | 0 | -0.44 | 27 | 27 |
SMO/Vitamin D3 | -0.06 | 0.22 | -10000 | 0 | -0.63 | 18 | 18 |
SHH Np/Cholesterol/Hhip | -0.08 | 0.17 | -10000 | 0 | -0.39 | 38 | 38 |
LRP2 | -0.022 | 0.11 | -10000 | 0 | -0.42 | 13 | 13 |
receptor-mediated endocytosis | -0.059 | 0.21 | -10000 | 0 | -0.62 | 17 | 17 |
SHH Np/Cholesterol/BOC | -0.044 | 0.14 | -10000 | 0 | -0.38 | 21 | 21 |
SHH Np/Cholesterol/CDO | -0.008 | 0.1 | -10000 | 0 | -0.38 | 12 | 12 |
mesenchymal cell differentiation | 0.08 | 0.17 | 0.38 | 38 | -10000 | 0 | 38 |
mol:Vitamin D3 | -0.043 | 0.19 | -10000 | 0 | -0.61 | 13 | 13 |
IHH N/PTCH2 | -0.079 | 0.2 | -10000 | 0 | -0.47 | 38 | 38 |
CDON | -0.007 | 0.1 | -10000 | 0 | -0.51 | 7 | 7 |
IHH N/PTCH1 | -0.052 | 0.19 | -10000 | 0 | -0.44 | 27 | 27 |
Megalin/LRPAP1 | -0.006 | 0.075 | -10000 | 0 | -0.28 | 13 | 13 |
PTCH2 | -0.054 | 0.18 | -10000 | 0 | -0.54 | 23 | 23 |
SHH Np/Cholesterol | -0.018 | 0.079 | -10000 | 0 | -0.35 | 10 | 10 |
PTCH1 | -0.052 | 0.19 | -10000 | 0 | -0.44 | 27 | 27 |
HHIP | -0.13 | 0.25 | -10000 | 0 | -0.55 | 50 | 50 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GRB2/SOS1/SHC | -0.1 | 0.21 | -10000 | 0 | -0.56 | 28 | 28 |
FYN | -0.11 | 0.31 | -10000 | 0 | -0.7 | 34 | 34 |
LAT/GRAP2/SLP76 | -0.12 | 0.25 | -10000 | 0 | -0.63 | 31 | 31 |
IKBKB | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
AKT1 | -0.062 | 0.2 | -10000 | 0 | -0.46 | 32 | 32 |
B2M | 0.011 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
IKBKG | -0.038 | 0.057 | -10000 | 0 | -0.16 | 25 | 25 |
MAP3K8 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.027 | 0.039 | -10000 | 0 | -0.091 | 45 | 45 |
integrin-mediated signaling pathway | 0.002 | 0.069 | -10000 | 0 | -0.32 | 8 | 8 |
LAT/GRAP2/SLP76/VAV1/PI3K Class IA | -0.11 | 0.3 | -10000 | 0 | -0.69 | 34 | 34 |
TRPV6 | -0.1 | 0.19 | -10000 | 0 | -0.44 | 45 | 45 |
CD28 | -0.042 | 0.17 | -10000 | 0 | -0.59 | 17 | 17 |
SHC1 | -0.1 | 0.3 | -10000 | 0 | -0.7 | 31 | 31 |
receptor internalization | -0.11 | 0.33 | -10000 | 0 | -0.77 | 31 | 31 |
PRF1 | -0.12 | 0.36 | -10000 | 0 | -1.1 | 19 | 19 |
KRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
COT/AKT1 | -0.041 | 0.16 | -10000 | 0 | -0.37 | 29 | 29 |
LAT | -0.11 | 0.31 | -10000 | 0 | -0.76 | 30 | 30 |
EntrezGene:6955 | -0.001 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
CD3D | -0.029 | 0.15 | -10000 | 0 | -0.59 | 13 | 13 |
CD3E | -0.035 | 0.16 | -10000 | 0 | -0.59 | 15 | 15 |
CD3G | -0.072 | 0.21 | -10000 | 0 | -0.61 | 26 | 26 |
RASGRP2 | -0.012 | 0.042 | -10000 | 0 | -0.16 | 11 | 11 |
RASGRP1 | -0.066 | 0.21 | -10000 | 0 | -0.5 | 31 | 31 |
HLA-A | 0.005 | 0.056 | -10000 | 0 | -0.53 | 2 | 2 |
RASSF5 | -0.01 | 0.11 | -10000 | 0 | -0.52 | 8 | 8 |
RAP1A/GTP/RAPL | 0.002 | 0.069 | -10000 | 0 | -0.32 | 8 | 8 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.002 | 0.062 | -10000 | 0 | -0.13 | 23 | 23 |
PDK1/CARD11/BCL10/MALT1/TRAF6 | -0.071 | 0.1 | -10000 | 0 | -0.28 | 30 | 30 |
PRKCA | -0.056 | 0.11 | -10000 | 0 | -0.29 | 27 | 27 |
GRAP2 | -0.033 | 0.16 | -10000 | 0 | -0.56 | 15 | 15 |
mol:IP3 | -0.064 | 0.2 | 0.19 | 25 | -0.46 | 30 | 55 |
EntrezGene:6957 | -0.001 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
TCR/CD3/MHC I/CD8 | -0.1 | 0.32 | -10000 | 0 | -0.76 | 28 | 28 |
ORAI1 | 0.064 | 0.11 | 0.26 | 45 | -10000 | 0 | 45 |
CSK | -0.1 | 0.3 | -10000 | 0 | -0.73 | 30 | 30 |
B7 family/CD28 | -0.18 | 0.34 | -10000 | 0 | -0.8 | 38 | 38 |
CHUK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TCR/CD3/MHC I/CD8/LCK/ZAP-70 | -0.13 | 0.36 | -10000 | 0 | -0.84 | 32 | 32 |
PTPN6 | -0.11 | 0.31 | -10000 | 0 | -0.74 | 30 | 30 |
VAV1 | -0.12 | 0.32 | -10000 | 0 | -0.7 | 38 | 38 |
Monovalent TCR/CD3 | -0.085 | 0.31 | -10000 | 0 | -0.68 | 29 | 29 |
CBL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
LCK | -0.12 | 0.33 | -10000 | 0 | -0.74 | 35 | 35 |
PAG1 | -0.11 | 0.3 | -10000 | 0 | -0.72 | 31 | 31 |
RAP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TCR/CD3/MHC I/CD8/LCK | -0.13 | 0.36 | -10000 | 0 | -0.83 | 32 | 32 |
CD80 | -0.048 | 0.18 | -10000 | 0 | -0.59 | 19 | 19 |
CD86 | -0.063 | 0.2 | -10000 | 0 | -0.58 | 24 | 24 |
PDK1/CARD11/BCL10/MALT1 | -0.086 | 0.12 | -10000 | 0 | -0.34 | 31 | 31 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GO:0035030 | -0.11 | 0.28 | -10000 | 0 | -0.63 | 38 | 38 |
CD8A | -0.069 | 0.2 | -10000 | 0 | -0.56 | 27 | 27 |
CD8B | -0.062 | 0.19 | -10000 | 0 | -0.55 | 25 | 25 |
PTPRC | -0.062 | 0.2 | -10000 | 0 | -0.57 | 24 | 24 |
PDK1/PKC theta | -0.086 | 0.25 | -10000 | 0 | -0.57 | 34 | 34 |
CSK/PAG1 | -0.099 | 0.29 | -10000 | 0 | -0.72 | 29 | 29 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
peptide-MHC class I | 0.011 | 0.042 | -10000 | 0 | -0.38 | 2 | 2 |
GRAP2/SLP76 | -0.13 | 0.29 | -10000 | 0 | -0.72 | 32 | 32 |
STIM1 | 0.033 | 0.052 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP | -0.002 | 0.082 | -10000 | 0 | -0.18 | 21 | 21 |
TCR/CD3/MHC I/CD8/LCK/ZAP-70/CBL/ubiquitin | -0.13 | 0.37 | -10000 | 0 | -0.87 | 30 | 30 |
mol:DAG | -0.078 | 0.16 | -10000 | 0 | -0.4 | 34 | 34 |
RAP1A/GDP | 0 | 0.027 | -10000 | 0 | -10000 | 0 | 0 |
PLCG1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CD247 | -0.033 | 0.16 | -10000 | 0 | -0.57 | 15 | 15 |
cytotoxic T cell degranulation | -0.11 | 0.33 | -10000 | 0 | -1 | 19 | 19 |
RAP1A/GTP | -0.006 | 0.014 | -10000 | 0 | -0.068 | 7 | 7 |
mol:PI-3-4-5-P3 | -0.082 | 0.24 | -10000 | 0 | -0.55 | 33 | 33 |
LAT/GRAP2/SLP76/VAV1/PLCgamma1 | -0.095 | 0.26 | 0.21 | 22 | -0.6 | 32 | 54 |
NRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ZAP70 | -0.03 | 0.15 | -10000 | 0 | -0.56 | 14 | 14 |
GRB2/SOS1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
LAT/GRAP2/SLP76/VAV1 | -0.12 | 0.24 | -10000 | 0 | -0.6 | 34 | 34 |
MALT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRAF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CD8 heterodimer | -0.091 | 0.23 | -10000 | 0 | -0.48 | 42 | 42 |
CARD11 | -0.13 | 0.24 | -10000 | 0 | -0.49 | 56 | 56 |
PRKCB | -0.075 | 0.14 | -10000 | 0 | -0.37 | 32 | 32 |
PRKCE | -0.054 | 0.11 | -10000 | 0 | -0.29 | 26 | 26 |
PRKCQ | -0.11 | 0.29 | -10000 | 0 | -0.66 | 35 | 35 |
LCP2 | -0.015 | 0.12 | -10000 | 0 | -0.56 | 9 | 9 |
BCL10 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of survival gene product expression | -0.049 | 0.17 | -10000 | 0 | -0.39 | 32 | 32 |
IKK complex | 0.003 | 0.062 | -10000 | 0 | -0.12 | 23 | 23 |
RAS family/GDP | -0.006 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K14 | -0.023 | 0.12 | -10000 | 0 | -0.3 | 22 | 22 |
PDPK1 | -0.056 | 0.19 | -10000 | 0 | -0.43 | 32 | 32 |
TCR/CD3/MHC I/CD8/Fyn | -0.13 | 0.36 | -10000 | 0 | -0.88 | 30 | 30 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PKM2 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
HDAC7 | 0.013 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/ARNT/Cbp/p300/Src-1 | -0.21 | 0.34 | -9999 | 0 | -0.84 | 22 | 22 |
SMAD4 | 0.009 | 0.046 | -9999 | 0 | -0.63 | 1 | 1 |
ID2 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
AP1 | -0.013 | 0.11 | -9999 | 0 | -0.4 | 14 | 14 |
ABCG2 | -0.3 | 0.52 | -9999 | 0 | -1.2 | 33 | 33 |
HIF1A | -0.027 | 0.077 | -9999 | 0 | -10000 | 0 | 0 |
TFF3 | -0.3 | 0.53 | -9999 | 0 | -1.2 | 34 | 34 |
GATA2 | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
AKT1 | -0.028 | 0.085 | -9999 | 0 | -10000 | 0 | 0 |
response to hypoxia | -0.045 | 0.089 | -9999 | 0 | -0.25 | 3 | 3 |
MCL1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NDRG1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 30 | 30 |
SERPINE1 | -0.29 | 0.53 | -9999 | 0 | -1.2 | 33 | 33 |
FECH | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
FURIN | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NCOA2 | 0.006 | 0.066 | -9999 | 0 | -0.63 | 2 | 2 |
EP300 | -0.017 | 0.12 | -9999 | 0 | -0.39 | 5 | 5 |
HMOX1 | -0.27 | 0.51 | -9999 | 0 | -1.2 | 30 | 30 |
BHLHE40 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
BHLHE41 | -0.28 | 0.52 | -9999 | 0 | -1.1 | 34 | 34 |
HIF1A/ARNT/SMAD3/SMAD4/SP1 | -0.051 | 0.086 | -9999 | 0 | -0.44 | 4 | 4 |
ENG | -0.009 | 0.13 | -9999 | 0 | -0.53 | 4 | 4 |
JUN | 0.008 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
RORA | -0.27 | 0.51 | -9999 | 0 | -1.1 | 32 | 32 |
ABCB1 | -0.31 | 0.46 | -9999 | 0 | -1.1 | 42 | 42 |
TFRC | -0.27 | 0.5 | -9999 | 0 | -1.1 | 30 | 30 |
CXCR4 | -0.29 | 0.53 | -9999 | 0 | -1.2 | 32 | 32 |
TF | -0.31 | 0.53 | -9999 | 0 | -1.2 | 38 | 38 |
CITED2 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
HIF1A/ARNT | -0.36 | 0.57 | -9999 | 0 | -1.3 | 38 | 38 |
LDHA | -0.035 | 0.048 | -9999 | 0 | -10000 | 0 | 0 |
ETS1 | -0.27 | 0.51 | -9999 | 0 | -1.2 | 29 | 29 |
PGK1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NOS2 | -0.33 | 0.54 | -9999 | 0 | -1.2 | 37 | 37 |
ITGB2 | -0.29 | 0.53 | -9999 | 0 | -1.2 | 33 | 33 |
ALDOA | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
Cbp/p300/CITED2 | -0.27 | 0.5 | -9999 | 0 | -1.2 | 28 | 28 |
FOS | -0.026 | 0.14 | -9999 | 0 | -0.55 | 13 | 13 |
HK2 | -0.27 | 0.5 | -9999 | 0 | -1.2 | 29 | 29 |
SP1 | -0.001 | 0.045 | -9999 | 0 | -10000 | 0 | 0 |
GCK | -0.046 | 0.27 | -9999 | 0 | -1.5 | 4 | 4 |
HK1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NPM1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
EGLN1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
CREB1 | 0.019 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PGM1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
SMAD3 | 0.003 | 0.08 | -9999 | 0 | -0.63 | 3 | 3 |
EDN1 | -0.062 | 0.29 | -9999 | 0 | -1 | 11 | 11 |
IGFBP1 | -0.3 | 0.52 | -9999 | 0 | -1.1 | 37 | 37 |
VEGFA | -0.13 | 0.34 | -9999 | 0 | -0.85 | 7 | 7 |
HIF1A/JAB1 | -0.022 | 0.03 | -9999 | 0 | -10000 | 0 | 0 |
CP | -0.36 | 0.55 | -9999 | 0 | -1.2 | 41 | 41 |
CXCL12 | -0.29 | 0.52 | -9999 | 0 | -1.2 | 34 | 34 |
COPS5 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4 | 0.009 | 0.069 | -9999 | 0 | -0.46 | 4 | 4 |
BNIP3 | -0.3 | 0.53 | -9999 | 0 | -1.2 | 37 | 37 |
EGLN3 | -0.28 | 0.51 | -9999 | 0 | -1.2 | 30 | 30 |
CA9 | -0.38 | 0.55 | -9999 | 0 | -1.2 | 41 | 41 |
TERT | -0.3 | 0.52 | -9999 | 0 | -1.2 | 32 | 32 |
ENO1 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
PFKL | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NCOA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ADM | -0.27 | 0.5 | -9999 | 0 | -1.1 | 31 | 31 |
ARNT | -0.027 | 0.077 | -9999 | 0 | -10000 | 0 | 0 |
HNF4A | 0.004 | 0.081 | -9999 | 0 | -0.63 | 3 | 3 |
ADFP | -0.29 | 0.49 | -9999 | 0 | -1.1 | 33 | 33 |
SLC2A1 | -0.14 | 0.34 | -9999 | 0 | -0.88 | 8 | 8 |
LEP | -0.29 | 0.51 | -9999 | 0 | -1.1 | 34 | 34 |
HIF1A/ARNT/Cbp/p300 | -0.22 | 0.35 | -9999 | 0 | -0.86 | 25 | 25 |
EPO | -0.11 | 0.27 | -9999 | 0 | -10000 | 0 | 0 |
CREBBP | -0.015 | 0.12 | -9999 | 0 | -0.38 | 4 | 4 |
HIF1A/ARNT/Cbp/p300/HDAC7 | -0.21 | 0.34 | -9999 | 0 | -0.85 | 22 | 22 |
PFKFB3 | -0.27 | 0.5 | -9999 | 0 | -1.1 | 29 | 29 |
NT5E | -0.29 | 0.53 | -9999 | 0 | -1.2 | 32 | 32 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CDK5R1/CDK5 | 0.016 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
VLDLR | -0.072 | 0.21 | -9999 | 0 | -0.56 | 28 | 28 |
CRKL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LRPAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FYN | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
ITGA3 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RELN/VLDLR/Fyn | -0.14 | 0.21 | -9999 | 0 | -0.45 | 46 | 46 |
MAPK8IP1/MKK7/MAP3K11/JNK1 | 0.018 | 0.072 | -9999 | 0 | -0.33 | 6 | 6 |
AKT1 | -0.099 | 0.15 | -9999 | 0 | -0.3 | 55 | 55 |
MAP2K7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAPGEF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAB1 | -0.072 | 0.19 | -9999 | 0 | -0.49 | 31 | 31 |
RELN/LRP8/DAB1 | -0.13 | 0.19 | -9999 | 0 | -0.41 | 47 | 47 |
LRPAP1/LRP8 | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
RELN/LRP8/DAB1/Fyn | -0.12 | 0.18 | -9999 | 0 | -0.38 | 49 | 49 |
DAB1/alpha3/beta1 Integrin | -0.15 | 0.17 | -9999 | 0 | -0.53 | 18 | 18 |
long-term memory | -0.15 | 0.21 | -9999 | 0 | -0.39 | 69 | 69 |
DAB1/LIS1 | -0.16 | 0.18 | -9999 | 0 | -0.43 | 35 | 35 |
DAB1/CRLK/C3G | -0.15 | 0.17 | -9999 | 0 | -0.52 | 18 | 18 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAB1/NCK2 | -0.16 | 0.18 | -9999 | 0 | -0.54 | 18 | 18 |
ARHGEF2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Src family inhibitors PP1 and PP2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRIN2A | -0.033 | 0.13 | -9999 | 0 | -0.44 | 18 | 18 |
CDK5R1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RELN | -0.17 | 0.26 | -9999 | 0 | -0.52 | 65 | 65 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/LRP8/Fyn | -0.096 | 0.17 | -9999 | 0 | -0.4 | 35 | 35 |
GRIN2A/RELN/LRP8/DAB1/Fyn | -0.13 | 0.2 | -9999 | 0 | -0.39 | 60 | 60 |
MAPK8 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/VLDLR/DAB1 | -0.17 | 0.21 | -9999 | 0 | -0.43 | 60 | 60 |
ITGB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP1B | -0.17 | 0.21 | -9999 | 0 | -0.4 | 72 | 72 |
RELN/LRP8 | -0.093 | 0.17 | -9999 | 0 | -0.4 | 33 | 33 |
GRIN2B/RELN/LRP8/DAB1/Fyn | -0.14 | 0.21 | -9999 | 0 | -0.4 | 59 | 59 |
PI3K | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PP2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha3/beta1 Integrin | 0.016 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
RAP1A | -0.12 | 0.18 | -9999 | 0 | -0.53 | 14 | 14 |
PAFAH1B1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8IP1 | -0.022 | 0.13 | -9999 | 0 | -0.52 | 12 | 12 |
CRLK/C3G | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRIN2B | -0.044 | 0.18 | -9999 | 0 | -0.59 | 18 | 18 |
NCK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
neuron differentiation | -0.052 | 0.12 | -9999 | 0 | -0.33 | 11 | 11 |
neuron adhesion | -0.1 | 0.17 | -9999 | 0 | -0.51 | 14 | 14 |
LRP8 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
GSK3B | -0.088 | 0.14 | -9999 | 0 | -0.42 | 13 | 13 |
RELN/VLDLR/DAB1/Fyn | -0.16 | 0.2 | -9999 | 0 | -0.41 | 61 | 61 |
MAP3K11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/VLDLR/DAB1/P13K | -0.11 | 0.16 | -9999 | 0 | -0.32 | 60 | 60 |
CDK5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPT | -0.086 | 0.21 | -9999 | 0 | -0.48 | 42 | 42 |
neuron migration | -0.1 | 0.18 | -9999 | 0 | -0.48 | 16 | 16 |
RELN/LRP8/DAB1/Fyn/MAPK8IP1/MKK7/MAP3K11/JNK1 | -0.053 | 0.12 | -9999 | 0 | -0.34 | 11 | 11 |
RELN/VLDLR | -0.12 | 0.19 | -9999 | 0 | -0.4 | 47 | 47 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
EFNB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EPHB2 | -0.002 | 0.093 | -10000 | 0 | -0.64 | 4 | 4 |
EFNB1 | 0.007 | 0.071 | -10000 | 0 | -0.38 | 6 | 6 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GDP | -0.097 | 0.18 | -10000 | 0 | -0.52 | 18 | 18 |
Ephrin B2/EPHB1-2 | -0.055 | 0.14 | -10000 | 0 | -0.36 | 18 | 18 |
neuron projection morphogenesis | -0.1 | 0.16 | -10000 | 0 | -0.5 | 18 | 18 |
Ephrin B1/EPHB1-2/Tiam1 | -0.093 | 0.2 | -10000 | 0 | -0.45 | 34 | 34 |
DNM1 | -0.005 | 0.096 | -10000 | 0 | -0.53 | 6 | 6 |
cell-cell signaling | 0 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K4 | -0.1 | 0.26 | -10000 | 0 | -0.68 | 32 | 32 |
YES1 | -0.15 | 0.34 | -10000 | 0 | -0.9 | 32 | 32 |
Ephrin B1/EPHB1-2/NCK2 | -0.047 | 0.14 | -10000 | 0 | -0.38 | 20 | 20 |
PI3K | -0.1 | 0.26 | -10000 | 0 | -0.68 | 32 | 32 |
mol:GDP | -0.093 | 0.19 | -10000 | 0 | -0.45 | 34 | 34 |
ITGA2B | -0.026 | 0.12 | -10000 | 0 | -0.43 | 16 | 16 |
endothelial cell proliferation | 0.016 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
FYN | -0.15 | 0.34 | -10000 | 0 | -0.9 | 32 | 32 |
MAP3K7 | -0.12 | 0.27 | -10000 | 0 | -0.72 | 32 | 32 |
FGR | -0.16 | 0.34 | -10000 | 0 | -0.91 | 32 | 32 |
TIAM1 | -0.075 | 0.2 | -10000 | 0 | -0.53 | 31 | 31 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RGS3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell adhesion | -0.11 | 0.26 | -10000 | 0 | -0.61 | 37 | 37 |
LYN | -0.15 | 0.34 | -10000 | 0 | -0.9 | 32 | 32 |
Ephrin B1/EPHB1-2/Src Family Kinases | -0.14 | 0.31 | -10000 | 0 | -0.84 | 32 | 32 |
Ephrin B1/EPHB1-2 | -0.14 | 0.29 | -10000 | 0 | -0.78 | 32 | 32 |
SRC | -0.15 | 0.34 | -10000 | 0 | -0.9 | 32 | 32 |
ITGB3 | -0.018 | 0.13 | -10000 | 0 | -0.57 | 10 | 10 |
EPHB1 | -0.12 | 0.22 | -10000 | 0 | -0.47 | 51 | 51 |
EPHB4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B2/EPHB4 | 0.016 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
alphaIIb/beta3 Integrin | -0.031 | 0.13 | -10000 | 0 | -0.35 | 25 | 25 |
BLK | -0.17 | 0.34 | -10000 | 0 | -0.92 | 32 | 32 |
HCK | -0.16 | 0.34 | -10000 | 0 | -0.92 | 32 | 32 |
regulation of stress fiber formation | 0.047 | 0.14 | 0.37 | 20 | -10000 | 0 | 20 |
MAPK8 | -0.092 | 0.25 | -10000 | 0 | -0.64 | 32 | 32 |
Ephrin B1/EPHB1-2/RGS3 | -0.047 | 0.14 | -10000 | 0 | -0.38 | 20 | 20 |
endothelial cell migration | -0.1 | 0.24 | -10000 | 0 | -0.62 | 32 | 32 |
NCK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTPN13 | -0.12 | 0.29 | -10000 | 0 | -0.73 | 34 | 34 |
regulation of focal adhesion formation | 0.047 | 0.14 | 0.37 | 20 | -10000 | 0 | 20 |
chemotaxis | 0.047 | 0.14 | 0.37 | 20 | -10000 | 0 | 20 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.1 | 0.17 | -10000 | 0 | -0.52 | 18 | 18 |
angiogenesis | -0.13 | 0.29 | -10000 | 0 | -0.77 | 32 | 32 |
LCK | -0.16 | 0.35 | -10000 | 0 | -0.92 | 32 | 32 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
FOXP3 | -0.056 | 0.2 | -10000 | 0 | -0.66 | 19 | 19 |
NFATC2 | -0.14 | 0.29 | -10000 | 0 | -0.65 | 37 | 37 |
NFATC3 | -0.017 | 0.084 | -10000 | 0 | -0.31 | 2 | 2 |
CD40LG | -0.35 | 0.46 | -10000 | 0 | -1 | 44 | 44 |
ITCH | 0.035 | 0.046 | -10000 | 0 | -10000 | 0 | 0 |
CBLB | 0.035 | 0.046 | -10000 | 0 | -10000 | 0 | 0 |
CD4-positive CD25-positive alpha-beta regulatory T cell lineage commitment | -0.34 | 0.49 | -10000 | 0 | -1.2 | 40 | 40 |
JUNB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/Calcineurin A alpha-beta B1 | -0.008 | 0.049 | -10000 | 0 | -0.31 | 5 | 5 |
T cell anergy | 0.005 | 0.085 | -10000 | 0 | -0.43 | 5 | 5 |
TLE4 | -0.1 | 0.25 | -10000 | 0 | -0.71 | 19 | 19 |
Jun/NFAT1-c-4/p21SNFT | -0.25 | 0.44 | -10000 | 0 | -1.1 | 27 | 27 |
AP-1/NFAT1-c-4 | -0.38 | 0.55 | -10000 | 0 | -1.2 | 41 | 41 |
IKZF1 | -0.12 | 0.29 | -10000 | 0 | -0.75 | 24 | 24 |
T-helper 2 cell differentiation | -0.18 | 0.3 | -10000 | 0 | -0.8 | 28 | 28 |
AP-1/NFAT1 | -0.14 | 0.22 | -10000 | 0 | -0.53 | 30 | 30 |
CALM1 | 0.02 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
EGR2 | -0.2 | 0.44 | -10000 | 0 | -1.3 | 18 | 18 |
EGR3 | -0.21 | 0.47 | -10000 | 0 | -1.4 | 18 | 18 |
NFAT1/FOXP3 | -0.15 | 0.32 | -10000 | 0 | -0.77 | 31 | 31 |
EGR1 | -0.03 | 0.15 | -10000 | 0 | -0.53 | 15 | 15 |
JUN | -0.008 | 0.055 | -10000 | 0 | -0.68 | 1 | 1 |
EGR4 | -0.07 | 0.19 | -10000 | 0 | -0.5 | 30 | 30 |
mol:Ca2+ | 0.008 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
GBP3 | -0.16 | 0.34 | -10000 | 0 | -0.81 | 34 | 34 |
FOSL1 | -0.037 | 0.16 | -10000 | 0 | -0.51 | 18 | 18 |
NFAT1-c-4/MAF/IRF4 | -0.25 | 0.46 | -10000 | 0 | -1.1 | 30 | 30 |
DGKA | -0.092 | 0.23 | -10000 | 0 | -0.65 | 16 | 16 |
CREM | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
NFAT1-c-4/PPARG | -0.22 | 0.42 | -10000 | 0 | -1.2 | 23 | 23 |
CTLA4 | -0.15 | 0.35 | -10000 | 0 | -0.87 | 29 | 29 |
NFAT1-c-4 (dimer)/EGR1 | -0.23 | 0.45 | -10000 | 0 | -1.2 | 25 | 25 |
NFAT1-c-4 (dimer)/EGR4 | -0.25 | 0.45 | -10000 | 0 | -1.1 | 27 | 27 |
FOS | -0.044 | 0.15 | -10000 | 0 | -0.56 | 13 | 13 |
IFNG | -0.31 | 0.44 | -10000 | 0 | -0.92 | 54 | 54 |
T cell activation | -0.14 | 0.22 | -10000 | 0 | -0.73 | 7 | 7 |
MAF | 0 | 0.086 | -10000 | 0 | -0.58 | 4 | 4 |
T-helper 2 cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
activation-induced cell death of T cells | 0.16 | 0.38 | 1.1 | 19 | -10000 | 0 | 19 |
TNF | -0.23 | 0.4 | -10000 | 0 | -1.1 | 27 | 27 |
FASLG | -0.32 | 0.59 | -10000 | 0 | -1.6 | 28 | 28 |
TBX21 | -0.079 | 0.21 | -10000 | 0 | -0.55 | 29 | 29 |
BATF3 | -0.017 | 0.12 | -10000 | 0 | -0.5 | 11 | 11 |
PRKCQ | -0.071 | 0.21 | -10000 | 0 | -0.63 | 24 | 24 |
PTPN1 | -0.086 | 0.21 | -10000 | 0 | -0.61 | 15 | 15 |
NFAT1-c-4/ICER1 | -0.22 | 0.42 | -10000 | 0 | -1.2 | 22 | 22 |
GATA3 | -0.026 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
T-helper 1 cell differentiation | -0.28 | 0.44 | -10000 | 0 | -0.89 | 54 | 54 |
IL2RA | -0.32 | 0.45 | -10000 | 0 | -1.1 | 42 | 42 |
T-helper 1 cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP3 | -0.09 | 0.22 | -10000 | 0 | -0.61 | 17 | 17 |
E2F1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PPARG | -0.001 | 0.092 | -10000 | 0 | -0.63 | 4 | 4 |
SLC3A2 | -0.086 | 0.21 | -10000 | 0 | -0.61 | 15 | 15 |
IRF4 | -0.093 | 0.23 | -10000 | 0 | -0.57 | 35 | 35 |
PTGS2 | -0.37 | 0.47 | -10000 | 0 | -1 | 51 | 51 |
CSF2 | -0.39 | 0.47 | -10000 | 0 | -0.99 | 55 | 55 |
JunB/Fra1/NFAT1-c-4 | -0.22 | 0.41 | -10000 | 0 | -1.1 | 22 | 22 |
IL4 | -0.18 | 0.32 | -10000 | 0 | -0.85 | 28 | 28 |
IL5 | -0.33 | 0.43 | -10000 | 0 | -1 | 39 | 39 |
IL2 | -0.14 | 0.22 | -10000 | 0 | -0.74 | 7 | 7 |
IL3 | -0.07 | 0.095 | -10000 | 0 | -0.78 | 2 | 2 |
RNF128 | 0.023 | 0.12 | -10000 | 0 | -0.7 | 5 | 5 |
NFATC1 | -0.16 | 0.39 | -10000 | 0 | -1.1 | 19 | 19 |
CDK4 | 0.11 | 0.2 | 0.67 | 9 | -10000 | 0 | 9 |
PTPRK | -0.086 | 0.21 | -10000 | 0 | -0.61 | 15 | 15 |
IL8 | -0.37 | 0.47 | -10000 | 0 | -1 | 50 | 50 |
POU2F1 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PTK2 | -0.074 | 0.2 | -9999 | 0 | -0.59 | 22 | 22 |
Syndecan-4/Syndesmos | -0.12 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
positive regulation of JNK cascade | -0.14 | 0.25 | -9999 | 0 | -0.6 | 36 | 36 |
Syndecan-4/ADAM12 | -0.17 | 0.29 | -9999 | 0 | -0.63 | 45 | 45 |
CCL5 | -0.057 | 0.19 | -9999 | 0 | -0.54 | 24 | 24 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DNM2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGA5 | -0.014 | 0.11 | -9999 | 0 | -0.48 | 10 | 10 |
SDCBP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLG | 0.001 | 0.032 | -9999 | 0 | -0.42 | 1 | 1 |
ADAM12 | -0.095 | 0.22 | -9999 | 0 | -0.53 | 38 | 38 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NUDT16L1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-4/PKC alpha | -0.03 | 0.038 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-4/Laminin alpha1 | -0.16 | 0.26 | -9999 | 0 | -0.61 | 37 | 37 |
Syndecan-4/CXCL12/CXCR4 | -0.15 | 0.27 | -9999 | 0 | -0.66 | 35 | 35 |
Syndecan-4/Laminin alpha3 | -0.13 | 0.25 | -9999 | 0 | -0.62 | 32 | 32 |
MDK | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
Syndecan-4/FZD7 | -0.13 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
Syndecan-4/Midkine | -0.13 | 0.24 | -9999 | 0 | -0.61 | 30 | 30 |
FZD7 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
Syndecan-4/FGFR1/FGF | -0.17 | 0.24 | -9999 | 0 | -0.6 | 36 | 36 |
THBS1 | -0.014 | 0.12 | -9999 | 0 | -0.54 | 9 | 9 |
integrin-mediated signaling pathway | -0.16 | 0.25 | -9999 | 0 | -0.57 | 44 | 44 |
positive regulation of MAPKKK cascade | -0.14 | 0.25 | -9999 | 0 | -0.6 | 36 | 36 |
Syndecan-4/TACI | -0.18 | 0.25 | -9999 | 0 | -0.61 | 38 | 38 |
CXCR4 | -0.037 | 0.16 | -9999 | 0 | -0.54 | 17 | 17 |
cell adhesion | -0.039 | 0.14 | -9999 | 0 | -0.36 | 24 | 24 |
Syndecan-4/Dynamin | -0.12 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
Syndecan-4/TSP1 | -0.13 | 0.25 | -9999 | 0 | -0.6 | 34 | 34 |
Syndecan-4/GIPC | -0.12 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
Syndecan-4/RANTES | -0.15 | 0.26 | -9999 | 0 | -0.64 | 35 | 35 |
ITGB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LAMA1 | -0.063 | 0.2 | -9999 | 0 | -0.56 | 25 | 25 |
LAMA3 | -0.01 | 0.11 | -9999 | 0 | -0.52 | 8 | 8 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCA | 0.03 | 0.077 | -9999 | 0 | -0.58 | 2 | 2 |
Syndecan-4/alpha-Actinin | -0.12 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
TFPI | -0.01 | 0.11 | -9999 | 0 | -0.52 | 8 | 8 |
F2 | -0.084 | 0.19 | -9999 | 0 | -0.46 | 38 | 38 |
alpha5/beta1 Integrin | -0.001 | 0.081 | -9999 | 0 | -0.34 | 10 | 10 |
positive regulation of cell adhesion | -0.16 | 0.26 | -9999 | 0 | -0.61 | 38 | 38 |
ACTN1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNC | -0.084 | 0.21 | -9999 | 0 | -0.53 | 34 | 34 |
Syndecan-4/CXCL12 | -0.14 | 0.25 | -9999 | 0 | -0.63 | 33 | 33 |
FGF6 | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CXCL12 | -0.036 | 0.15 | -9999 | 0 | -0.47 | 19 | 19 |
TNFRSF13B | -0.099 | 0.22 | -9999 | 0 | -0.53 | 39 | 39 |
FGF2 | -0.036 | 0.16 | -9999 | 0 | -0.53 | 17 | 17 |
FGFR1 | -0.025 | 0.14 | -9999 | 0 | -0.53 | 13 | 13 |
Syndecan-4/PI-4-5-P2 | -0.13 | 0.23 | -9999 | 0 | -0.6 | 31 | 31 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FN1 | -0.099 | 0.22 | -9999 | 0 | -0.53 | 40 | 40 |
cell migration | -0.006 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
PRKCD | 0.015 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
vasculogenesis | -0.13 | 0.24 | -9999 | 0 | -0.58 | 34 | 34 |
SDC4 | -0.14 | 0.25 | -9999 | 0 | -0.64 | 31 | 31 |
Syndecan-4/Tenascin C | -0.17 | 0.27 | -9999 | 0 | -0.6 | 44 | 44 |
Syndecan-4/PI-4-5-P2/PKC alpha | -0.024 | 0.03 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-4/Syntenin | -0.12 | 0.23 | -9999 | 0 | -0.6 | 30 | 30 |
MMP9 | -0.089 | 0.22 | -9999 | 0 | -0.55 | 34 | 34 |
Rac1/GTP | -0.041 | 0.14 | -9999 | 0 | -0.37 | 24 | 24 |
cytoskeleton organization | -0.12 | 0.22 | -9999 | 0 | -0.57 | 30 | 30 |
GIPC1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
Syndecan-4/TFPI | -0.13 | 0.25 | -9999 | 0 | -0.63 | 31 | 31 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Sortilin/TRAF6 | 0.015 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
Necdin/E2F1 | 0.011 | 0.051 | -10000 | 0 | -0.33 | 4 | 4 |
proNGF (dimer)/p75(NTR)/Sortilin/NADE/14-3-3 E | -0.092 | 0.2 | -10000 | 0 | -0.4 | 48 | 48 |
NGF (dimer)/p75(NTR)/BEX1 | -0.14 | 0.22 | -10000 | 0 | -0.46 | 56 | 56 |
NT-4/5 (dimer)/p75(NTR) | -0.097 | 0.19 | -10000 | 0 | -0.38 | 53 | 53 |
IKBKB | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
AKT1 | -0.07 | 0.17 | -10000 | 0 | -0.36 | 42 | 42 |
IKBKG | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BDNF | -0.034 | 0.16 | -10000 | 0 | -0.54 | 16 | 16 |
MGDIs/NGR/p75(NTR)/LINGO1 | -0.089 | 0.18 | -10000 | 0 | -0.44 | 30 | 30 |
FURIN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
proBDNF (dimer)/p75(NTR)/Sortilin | -0.088 | 0.19 | -10000 | 0 | -0.45 | 31 | 31 |
LINGO1 | -0.034 | 0.14 | -10000 | 0 | -0.45 | 19 | 19 |
Sortilin/TRAF6/NRIF | -0.013 | 0.059 | -10000 | 0 | -10000 | 0 | 0 |
proBDNF (dimer) | -0.034 | 0.16 | -10000 | 0 | -0.54 | 16 | 16 |
NTRK1 | -0.057 | 0.18 | -10000 | 0 | -0.53 | 24 | 24 |
RTN4R | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
neuron apoptosis | -0.099 | 0.22 | -10000 | 0 | -0.69 | 14 | 14 |
IRAK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC1 | -0.097 | 0.19 | -10000 | 0 | -0.43 | 42 | 42 |
ARHGDIA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoA/GTP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Gamma Secretase | 0.036 | 0 | -10000 | 0 | -10000 | 0 | 0 |
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-H1 | -0.088 | 0.19 | -10000 | 0 | -0.4 | 44 | 44 |
MAGEH1 | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
proNGF (dimer)/p75(NTR)/Sortilin/Necdin | -0.088 | 0.19 | -10000 | 0 | -0.4 | 43 | 43 |
Mammalian IAPs/DIABLO | 0.015 | 0.065 | -10000 | 0 | -0.35 | 3 | 3 |
proNGF (dimer) | -0.053 | 0.18 | -10000 | 0 | -0.53 | 23 | 23 |
MAGED1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
APP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT-4/5 (dimer) | -0.014 | 0.089 | -10000 | 0 | -0.42 | 9 | 9 |
ZNF274 | -0.015 | 0.13 | -10000 | 0 | -0.64 | 8 | 8 |
RhoA/GDP/RHOGDI | -0.076 | 0.17 | -10000 | 0 | -0.36 | 42 | 42 |
NGF | -0.053 | 0.18 | -10000 | 0 | -0.53 | 23 | 23 |
cell cycle arrest | -0.086 | 0.17 | -10000 | 0 | -0.36 | 42 | 42 |
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK | -0.046 | 0.13 | -10000 | 0 | -0.29 | 33 | 33 |
NT-4/5 (dimer)/p75(NTR)/TRAF6 | -0.074 | 0.16 | -10000 | 0 | -0.41 | 26 | 26 |
NCSTN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | -0.12 | 0.21 | -10000 | 0 | -0.45 | 47 | 47 |
PSENEN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:ceramide | -0.083 | 0.18 | -10000 | 0 | -0.39 | 42 | 42 |
NGF (dimer)/p75(NTR)/TRAF6/RIP2/IRAK/p62/Atypical PKCs | -0.029 | 0.11 | -10000 | 0 | -0.41 | 3 | 3 |
p75(NTR)/beta APP | -0.079 | 0.17 | -10000 | 0 | -0.37 | 48 | 48 |
BEX1 | -0.052 | 0.17 | -10000 | 0 | -0.5 | 23 | 23 |
mol:GDP | -0.1 | 0.19 | -10000 | 0 | -0.38 | 59 | 59 |
NGF (dimer) | -0.1 | 0.18 | -10000 | 0 | -0.39 | 41 | 41 |
MGDIs/NGR/p75(NTR)/LINGO1/RHOGDI | -0.073 | 0.16 | -10000 | 0 | -0.39 | 30 | 30 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1/GTP | -0.084 | 0.17 | -10000 | 0 | -0.37 | 42 | 42 |
MYD88 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CHUK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGF (dimer)/p75(NTR)/PKA | -0.12 | 0.21 | -10000 | 0 | -0.45 | 47 | 47 |
RHOB | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAGE-G1/E2F1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT3 (dimer) | -0.036 | 0.16 | -10000 | 0 | -0.56 | 16 | 16 |
TP53 | -0.09 | 0.19 | -10000 | 0 | -0.45 | 23 | 23 |
PRDM4 | -0.084 | 0.18 | -10000 | 0 | -0.39 | 42 | 42 |
BDNF (dimer) | -0.18 | 0.24 | -10000 | 0 | -0.48 | 62 | 62 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SORT1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
activation of caspase activity | -0.11 | 0.18 | -10000 | 0 | -0.39 | 48 | 48 |
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 | -0.083 | 0.18 | -10000 | 0 | -0.4 | 42 | 42 |
RHOC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
XIAP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK10 | -0.086 | 0.2 | -10000 | 0 | -0.5 | 20 | 20 |
DIABLO | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SMPD2 | -0.084 | 0.18 | -10000 | 0 | -0.39 | 42 | 42 |
APH1B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
APH1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
proNGF (dimer)/p75(NTR)/Sortilin | -0.1 | 0.2 | -10000 | 0 | -0.44 | 42 | 42 |
PSEN1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
APAF-1/Pro-Caspase 9 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT3 (dimer)/p75(NTR) | -0.11 | 0.21 | -10000 | 0 | -0.4 | 60 | 60 |
MAPK8 | -0.063 | 0.18 | -10000 | 0 | -0.56 | 11 | 11 |
MAPK9 | -0.063 | 0.18 | -10000 | 0 | -0.56 | 11 | 11 |
APAF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NTF3 | -0.036 | 0.16 | -10000 | 0 | -0.57 | 16 | 16 |
NTF4 | -0.014 | 0.089 | -10000 | 0 | -0.42 | 9 | 9 |
NDN | 0.002 | 0.07 | -10000 | 0 | -0.47 | 4 | 4 |
RAC1/GDP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoA-B-C/GDP | -0.1 | 0.16 | -10000 | 0 | -0.35 | 48 | 48 |
p75 CTF/Sortilin/TRAF6/NRIF | 0.013 | 0.081 | -10000 | 0 | -0.35 | 9 | 9 |
RhoA-B-C/GTP | -0.12 | 0.21 | -10000 | 0 | -0.44 | 47 | 47 |
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF | -0.077 | 0.19 | -10000 | 0 | -0.41 | 35 | 35 |
proBDNF (dimer)/p75(NTR)/Sortilin/TRAF6 | -0.073 | 0.17 | -10000 | 0 | -0.41 | 31 | 31 |
PRKACB | -0.017 | 0.13 | -10000 | 0 | -0.61 | 9 | 9 |
proBDNF (dimer)/p75 ECD | -0.016 | 0.12 | -10000 | 0 | -0.39 | 16 | 16 |
ChemicalAbstracts:86-01-1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BIRC3 | -0.016 | 0.12 | -10000 | 0 | -0.48 | 11 | 11 |
BIRC2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
neuron projection morphogenesis | -0.098 | 0.18 | 0.2 | 7 | -0.4 | 39 | 46 |
BAD | -0.066 | 0.18 | -10000 | 0 | -0.53 | 13 | 13 |
RIPK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGFR | -0.12 | 0.24 | -10000 | 0 | -0.52 | 48 | 48 |
CYCS | -0.072 | 0.17 | -10000 | 0 | -0.37 | 42 | 42 |
ADAM17 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGF (dimer)/p75(NTR)/TRAF6/RIP2 | -0.081 | 0.18 | -10000 | 0 | -0.39 | 42 | 42 |
BCL2L11 | -0.066 | 0.18 | -10000 | 0 | -0.53 | 13 | 13 |
BDNF (dimer)/p75(NTR) | -0.11 | 0.21 | -10000 | 0 | -0.41 | 58 | 58 |
PI3K | -0.081 | 0.18 | -10000 | 0 | -0.39 | 42 | 42 |
proNGF (dimer)/p75(NTR)/Sortilin/MAGE-G1 | -0.083 | 0.18 | -10000 | 0 | -0.4 | 42 | 42 |
NDNL2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCI | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
NGF (dimer)/p75(NTR) | -0.12 | 0.22 | -10000 | 0 | -0.44 | 59 | 59 |
ChemicalAbstracts:146-91-8 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
proNGF (dimer)/p75(NTR)/Sortilin/NRAGE | -0.083 | 0.18 | -10000 | 0 | -0.4 | 42 | 42 |
TRAF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLG | -0.001 | 0.03 | -10000 | 0 | -0.42 | 1 | 1 |
oligodendrocyte cell fate commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP6 | -0.097 | 0.2 | -10000 | 0 | -0.4 | 50 | 50 |
SQSTM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGFRAP1 | -0.025 | 0.15 | -10000 | 0 | -0.64 | 11 | 11 |
CASP3 | -0.059 | 0.17 | -10000 | 0 | -0.48 | 13 | 13 |
E2F1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP9 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IKK complex | -0.085 | 0.14 | -10000 | 0 | -0.48 | 8 | 8 |
NGF (dimer)/TRKA | -0.079 | 0.19 | -10000 | 0 | -0.42 | 42 | 42 |
MMP7 | -0.14 | 0.25 | -10000 | 0 | -0.53 | 55 | 55 |
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF | -0.087 | 0.19 | -10000 | 0 | -0.39 | 46 | 46 |
MMP3 | -0.16 | 0.26 | -10000 | 0 | -0.53 | 60 | 60 |
APAF-1/Caspase 9 | -0.077 | 0.12 | -10000 | 0 | -0.51 | 5 | 5 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PTK2 | -0.034 | 0.05 | -9999 | 0 | -10000 | 0 | 0 |
Crk/p130 Cas/Paxillin | -0.085 | 0.14 | -9999 | 0 | -0.41 | 19 | 19 |
JUN | -0.053 | 0.15 | -9999 | 0 | -0.42 | 17 | 17 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET51/GFRalpha1/GDNF/GRB10 | -0.12 | 0.22 | -9999 | 0 | -0.48 | 43 | 43 |
RAP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FRS2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAP1A/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET51/GFRalpha1/GDNF/DOK1 | -0.12 | 0.22 | -9999 | 0 | -0.47 | 43 | 43 |
EntrezGene:5979 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CRK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/Enigma | -0.057 | 0.15 | -9999 | 0 | -0.37 | 28 | 28 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAP1A/GTP | -0.12 | 0.18 | -9999 | 0 | -0.42 | 43 | 43 |
GRB7 | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
RET51/GFRalpha1/GDNF | -0.12 | 0.22 | -9999 | 0 | -0.47 | 43 | 43 |
MAPKKK cascade | -0.1 | 0.17 | -9999 | 0 | -0.53 | 17 | 17 |
BCAR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/IRS1 | -0.068 | 0.16 | -9999 | 0 | -0.39 | 32 | 32 |
lamellipodium assembly | -0.079 | 0.13 | -9999 | 0 | -0.34 | 30 | 30 |
RET51/GFRalpha1/GDNF/SHC | -0.12 | 0.22 | -9999 | 0 | -0.47 | 43 | 43 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/SHC | -0.056 | 0.14 | -9999 | 0 | -0.37 | 28 | 28 |
RET9/GFRalpha1/GDNF/Shank3 | -0.058 | 0.15 | -9999 | 0 | -0.38 | 28 | 28 |
MAPK3 | -0.088 | 0.19 | -9999 | 0 | -0.4 | 43 | 43 |
DOK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DOK6 | -0.044 | 0.18 | -9999 | 0 | -0.59 | 18 | 18 |
PXN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
neurite development | -0.083 | 0.19 | -9999 | 0 | -0.53 | 20 | 20 |
DOK5 | -0.065 | 0.2 | -9999 | 0 | -0.56 | 26 | 26 |
GFRA1 | -0.12 | 0.24 | -9999 | 0 | -0.54 | 46 | 46 |
MAPK8 | -0.061 | 0.16 | -9999 | 0 | -0.44 | 17 | 17 |
HRAS/GTP | -0.12 | 0.19 | -9999 | 0 | -0.44 | 43 | 43 |
tube development | -0.049 | 0.14 | -9999 | 0 | -0.35 | 28 | 28 |
MAPK1 | -0.088 | 0.19 | -9999 | 0 | -0.44 | 31 | 31 |
RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 | -0.03 | 0.11 | -9999 | 0 | -0.28 | 27 | 27 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDLIM7 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RET51/GFRalpha1/GDNF/Dok6 | -0.13 | 0.25 | -9999 | 0 | -0.5 | 50 | 50 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET51/GFRalpha1/GDNF/Dok4 | -0.12 | 0.22 | -9999 | 0 | -0.47 | 43 | 43 |
RET51/GFRalpha1/GDNF/Dok5 | -0.16 | 0.26 | -9999 | 0 | -0.5 | 56 | 56 |
PRKCA | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
HRAS/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CREB1 | -0.056 | 0.16 | -9999 | 0 | -0.4 | 27 | 27 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 | -0.03 | 0.11 | -9999 | 0 | -0.28 | 27 | 27 |
RET51/GFRalpha1/GDNF/Grb7 | -0.12 | 0.22 | -9999 | 0 | -0.48 | 43 | 43 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET | -0.11 | 0.23 | -9999 | 0 | -0.51 | 46 | 46 |
DOK4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JNK cascade | -0.052 | 0.15 | -9999 | 0 | -0.41 | 17 | 17 |
RET9/GFRalpha1/GDNF/FRS2 | -0.056 | 0.14 | -9999 | 0 | -0.37 | 28 | 28 |
SHANK3 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
RASA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 | -0.03 | 0.11 | -9999 | 0 | -0.28 | 27 | 27 |
RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 | -0.072 | 0.16 | -9999 | 0 | -0.36 | 38 | 38 |
RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK | -0.072 | 0.16 | -9999 | 0 | -0.36 | 38 | 38 |
RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 | -0.081 | 0.19 | -9999 | 0 | -0.41 | 38 | 38 |
PI3K | -0.086 | 0.22 | -9999 | 0 | -0.52 | 31 | 31 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET9/GFRalpha1/GDNF/Shank3/Grb2 | -0.048 | 0.14 | -9999 | 0 | -0.35 | 28 | 28 |
GRB10 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
activation of MAPKK activity | -0.058 | 0.14 | -9999 | 0 | -0.41 | 16 | 16 |
RET51/GFRalpha1/GDNF/FRS2 | -0.12 | 0.22 | -9999 | 0 | -0.47 | 43 | 43 |
GAB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRS1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
IRS2 | 0.003 | 0.072 | -9999 | 0 | -0.56 | 3 | 3 |
RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 | -0.081 | 0.19 | -9999 | 0 | -0.41 | 38 | 38 |
RET51/GFRalpha1/GDNF/PKC alpha | -0.12 | 0.23 | -9999 | 0 | -0.49 | 43 | 43 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GDNF | 0.007 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RET51/GFRalpha1/GDNF/IRS1 | -0.13 | 0.23 | -9999 | 0 | -0.5 | 45 | 45 |
Rac1/GTP | -0.094 | 0.15 | -9999 | 0 | -0.44 | 23 | 23 |
RET9/GFRalpha1/GDNF | -0.071 | 0.16 | -9999 | 0 | -0.34 | 46 | 46 |
GFRalpha1/GDNF | -0.084 | 0.18 | -9999 | 0 | -0.4 | 46 | 46 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
AKT1 | -0.07 | 0.28 | -10000 | 0 | -0.73 | 20 | 20 |
PTK2B | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.037 | 0.27 | -10000 | 0 | -0.94 | 12 | 12 |
EDN1 | -0.042 | 0.2 | -10000 | 0 | -0.5 | 19 | 19 |
EDN3 | -0.1 | 0.23 | -10000 | 0 | -0.55 | 39 | 39 |
EDN2 | -0.073 | 0.2 | -10000 | 0 | -0.51 | 31 | 31 |
HRAS/GDP | -0.066 | 0.21 | -10000 | 0 | -0.53 | 21 | 21 |
ETA receptor/Endothelin-1/Gq/GTP/PLC beta | -0.044 | 0.19 | -10000 | 0 | -0.46 | 22 | 22 |
ADCY4 | -0.078 | 0.25 | -10000 | 0 | -0.65 | 22 | 22 |
ADCY5 | -0.16 | 0.28 | -10000 | 0 | -0.6 | 42 | 42 |
ADCY6 | -0.075 | 0.24 | -10000 | 0 | -0.64 | 21 | 21 |
ADCY7 | -0.075 | 0.24 | -10000 | 0 | -0.64 | 21 | 21 |
ADCY1 | -0.1 | 0.26 | -10000 | 0 | -0.63 | 27 | 27 |
ADCY2 | -0.12 | 0.29 | -10000 | 0 | -0.67 | 32 | 32 |
ADCY3 | -0.075 | 0.24 | -10000 | 0 | -0.64 | 21 | 21 |
ADCY8 | -0.084 | 0.24 | -10000 | 0 | -0.62 | 23 | 23 |
ADCY9 | -0.077 | 0.24 | -10000 | 0 | -0.64 | 21 | 21 |
arachidonic acid secretion | -0.091 | 0.21 | -10000 | 0 | -0.52 | 25 | 25 |
ETB receptor/Endothelin-1/Gq/GTP | -0.019 | 0.15 | -10000 | 0 | -0.43 | 15 | 15 |
GNAO1 | -0.099 | 0.22 | -10000 | 0 | -0.53 | 39 | 39 |
HRAS | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
ETA receptor/Endothelin-1/G12/GTP | -0.053 | 0.28 | 0.37 | 14 | -0.68 | 20 | 34 |
ETA receptor/Endothelin-1/Gs/GTP | -0.067 | 0.28 | 0.35 | 14 | -0.67 | 22 | 36 |
mol:GTP | 0.001 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
COL3A1 | -0.1 | 0.35 | -10000 | 0 | -0.82 | 27 | 27 |
EDNRB | -0.01 | 0.11 | -10000 | 0 | -0.62 | 6 | 6 |
response to oxidative stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CYSLTR2 | -0.13 | 0.36 | -10000 | 0 | -0.79 | 36 | 36 |
CYSLTR1 | -0.11 | 0.34 | -10000 | 0 | -0.81 | 28 | 28 |
SLC9A1 | -0.039 | 0.14 | 0.19 | 14 | -0.36 | 17 | 31 |
mol:GDP | -0.077 | 0.23 | -10000 | 0 | -0.54 | 25 | 25 |
SLC9A3 | -0.2 | 0.35 | -10000 | 0 | -0.66 | 59 | 59 |
RAF1 | -0.068 | 0.2 | -10000 | 0 | -0.54 | 17 | 17 |
JUN | -0.019 | 0.21 | -10000 | 0 | -0.72 | 10 | 10 |
JAK2 | -0.074 | 0.28 | -10000 | 0 | -0.71 | 21 | 21 |
mol:IP3 | -0.043 | 0.19 | -10000 | 0 | -0.5 | 18 | 18 |
ETA receptor/Endothelin-1 | -0.077 | 0.34 | 0.44 | 14 | -0.77 | 23 | 37 |
PLCB1 | -0.053 | 0.19 | -10000 | 0 | -0.61 | 20 | 20 |
PLCB2 | -0.004 | 0.089 | -10000 | 0 | -0.49 | 6 | 6 |
ETA receptor/Endothelin-3 | -0.11 | 0.24 | -10000 | 0 | -0.56 | 34 | 34 |
FOS | -0.066 | 0.24 | -10000 | 0 | -0.75 | 14 | 14 |
Gai/GDP | -0.089 | 0.28 | -10000 | 0 | -0.85 | 21 | 21 |
CRK | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca ++ | -0.094 | 0.31 | -10000 | 0 | -0.78 | 25 | 25 |
BCAR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCB1 | -0.042 | 0.18 | -10000 | 0 | -0.47 | 18 | 18 |
GNAQ | 0.006 | 0.066 | -10000 | 0 | -0.63 | 2 | 2 |
GNAZ | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
GNAL | -0.019 | 0.12 | -10000 | 0 | -0.49 | 12 | 12 |
Gs family/GDP | -0.11 | 0.19 | -10000 | 0 | -0.49 | 28 | 28 |
ETA receptor/Endothelin-1/Gq/GTP | -0.031 | 0.19 | -10000 | 0 | -0.48 | 20 | 20 |
MAPK14 | -0.025 | 0.15 | -10000 | 0 | -0.5 | 10 | 10 |
TRPC6 | -0.044 | 0.29 | -10000 | 0 | -1 | 12 | 12 |
GNAI2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
ETB receptor/Endothelin-1/Gq/GTP/PLC beta | -0.033 | 0.16 | -10000 | 0 | -0.44 | 16 | 16 |
ETB receptor/Endothelin-2 | -0.059 | 0.17 | -10000 | 0 | -0.4 | 35 | 35 |
ETB receptor/Endothelin-3 | -0.082 | 0.18 | -10000 | 0 | -0.4 | 45 | 45 |
ETB receptor/Endothelin-1 | -0.033 | 0.18 | -10000 | 0 | -0.56 | 14 | 14 |
MAPK3 | -0.067 | 0.22 | -10000 | 0 | -0.64 | 17 | 17 |
MAPK1 | -0.067 | 0.22 | -10000 | 0 | -0.64 | 17 | 17 |
Rac1/GDP | -0.065 | 0.21 | -10000 | 0 | -0.56 | 18 | 18 |
cAMP biosynthetic process | -0.12 | 0.26 | -10000 | 0 | -0.6 | 31 | 31 |
MAPK8 | -0.032 | 0.23 | -10000 | 0 | -0.68 | 15 | 15 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ETB receptor/Endothelin-1/Gi/GTP | -0.046 | 0.17 | -10000 | 0 | -0.42 | 22 | 22 |
p130Cas/CRK/Src/PYK2 | -0.073 | 0.23 | -10000 | 0 | -0.64 | 19 | 19 |
mol:K + | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
G12/GDP | -0.065 | 0.21 | -10000 | 0 | -0.54 | 20 | 20 |
COL1A2 | -0.11 | 0.39 | -10000 | 0 | -1 | 23 | 23 |
EntrezGene:2778 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ETA receptor/Endothelin-2 | -0.093 | 0.21 | -10000 | 0 | -0.52 | 29 | 29 |
mol:DAG | -0.043 | 0.19 | -10000 | 0 | -0.5 | 18 | 18 |
MAP2K2 | -0.063 | 0.2 | -10000 | 0 | -0.51 | 21 | 21 |
MAP2K1 | -0.063 | 0.2 | -10000 | 0 | -0.51 | 21 | 21 |
EDNRA | -0.042 | 0.22 | -10000 | 0 | -0.62 | 17 | 17 |
positive regulation of muscle contraction | -0.055 | 0.25 | -10000 | 0 | -0.66 | 19 | 19 |
Gq family/GDP | -0.1 | 0.19 | -10000 | 0 | -0.57 | 21 | 21 |
HRAS/GTP | -0.074 | 0.2 | -10000 | 0 | -0.49 | 25 | 25 |
PRKCH | -0.035 | 0.18 | -10000 | 0 | -0.51 | 14 | 14 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCA | -0.039 | 0.18 | -10000 | 0 | -0.54 | 14 | 14 |
PRKCB | -0.075 | 0.23 | -10000 | 0 | -0.54 | 29 | 29 |
PRKCE | -0.034 | 0.18 | -10000 | 0 | -0.51 | 14 | 14 |
PRKCD | -0.035 | 0.18 | -10000 | 0 | -0.48 | 17 | 17 |
PRKCG | -0.11 | 0.22 | -10000 | 0 | -0.49 | 31 | 31 |
regulation of vascular smooth muscle contraction | -0.079 | 0.27 | -10000 | 0 | -0.88 | 14 | 14 |
PRKCQ | -0.076 | 0.22 | -10000 | 0 | -0.55 | 21 | 21 |
PLA2G4A | -0.099 | 0.23 | -10000 | 0 | -0.56 | 25 | 25 |
GNA14 | -0.01 | 0.12 | -10000 | 0 | -0.6 | 7 | 7 |
GNA15 | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
GNA12 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNA11 | 0.012 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.053 | 0.28 | 0.37 | 14 | -0.7 | 19 | 33 |
MMP1 | -0.18 | 0.4 | -10000 | 0 | -1 | 30 | 30 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CDKN2B | -0.035 | 0.15 | -10000 | 0 | -0.55 | 15 | 15 |
CDKN2C | 0.018 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
CDKN2A | -0.055 | 0.17 | -10000 | 0 | -0.48 | 26 | 26 |
CCND2 | 0.018 | 0.082 | 0.22 | 19 | -0.14 | 11 | 30 |
RB1 | -0.014 | 0.084 | -10000 | 0 | -0.23 | 19 | 19 |
CDK4 | 0.027 | 0.08 | 0.24 | 19 | -10000 | 0 | 19 |
CDK6 | 0.026 | 0.084 | 0.24 | 19 | -10000 | 0 | 19 |
G1/S progression | 0.014 | 0.083 | 0.23 | 19 | -10000 | 0 | 19 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
EGF/EGFR | -0.14 | 0.16 | -9999 | 0 | -0.37 | 48 | 48 |
EGF/EGFR dimer/SHC/GRB2/SOS1 | -0.08 | 0.14 | -9999 | 0 | -0.33 | 33 | 33 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EDNRA | -0.025 | 0.14 | -9999 | 0 | -0.58 | 12 | 12 |
response to oxidative stress | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGF | -0.2 | 0.26 | -9999 | 0 | -0.5 | 79 | 79 |
EGF/EGFR dimer/SHC | -0.11 | 0.17 | -9999 | 0 | -0.4 | 33 | 33 |
mol:GDP | -0.1 | 0.13 | -9999 | 0 | -0.33 | 33 | 33 |
mol:Ca2+ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EDN1 | -0.027 | 0.14 | -9999 | 0 | -0.52 | 14 | 14 |
GRB2/SOS1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HRAS/GTP | -0.09 | 0.12 | -9999 | 0 | -0.35 | 1 | 1 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HRAS/GDP | -0.092 | 0.12 | -9999 | 0 | -0.36 | 1 | 1 |
FRAP1 | -0.078 | 0.14 | -9999 | 0 | -0.31 | 33 | 33 |
EGF/EGFR dimer | -0.14 | 0.2 | -9999 | 0 | -0.36 | 80 | 80 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ETA receptor/Endothelin-1 | -0.038 | 0.14 | -9999 | 0 | -0.4 | 26 | 26 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BMP7/BMPR2/BMPR1A-1B/FS | -0.18 | 0.24 | -9999 | 0 | -0.42 | 80 | 80 |
SMAD6-7/SMURF1 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NOG | -0.024 | 0.11 | -9999 | 0 | -0.42 | 15 | 15 |
SMAD9 | -0.083 | 0.18 | -9999 | 0 | -0.52 | 23 | 23 |
SMAD4 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
SMAD5 | -0.06 | 0.16 | -9999 | 0 | -0.42 | 18 | 18 |
BMP7/USAG1 | -0.21 | 0.28 | -9999 | 0 | -0.5 | 83 | 83 |
SMAD5/SKI | -0.051 | 0.15 | -9999 | 0 | -0.41 | 16 | 16 |
SMAD1 | 0.026 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
BMP2 | -0.01 | 0.11 | -9999 | 0 | -0.52 | 8 | 8 |
SMAD1/SMAD1/SMAD4 | -0.001 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
BMPR1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMPR1B | -0.12 | 0.24 | -9999 | 0 | -0.54 | 46 | 46 |
BMPR1A-1B/BAMBI | -0.1 | 0.2 | -9999 | 0 | -0.44 | 37 | 37 |
AHSG | -0.01 | 0.085 | -9999 | 0 | -0.42 | 8 | 8 |
CER1 | -0.013 | 0.084 | -9999 | 0 | -0.42 | 8 | 8 |
BMP2-4/CER1 | -0.018 | 0.1 | -9999 | 0 | -0.4 | 8 | 8 |
BMP2-4/BMPR2/BMPR1A-1B/RGM/ENDOFIN/GADD34/PP1CA | -0.073 | 0.18 | -9999 | 0 | -0.43 | 26 | 26 |
BMP2-4 (homodimer) | -0.013 | 0.11 | -9999 | 0 | -0.38 | 15 | 15 |
RGMB | -0.001 | 0.074 | -9999 | 0 | -0.42 | 6 | 6 |
BMP6/BMPR2/BMPR1A-1B | -0.053 | 0.15 | -9999 | 0 | -0.37 | 28 | 28 |
RGMA | -0.14 | 0.26 | -9999 | 0 | -0.58 | 50 | 50 |
SMURF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP | -0.074 | 0.17 | -9999 | 0 | -0.41 | 26 | 26 |
BMP2-4/USAG1 | -0.09 | 0.2 | -9999 | 0 | -0.43 | 42 | 42 |
SMAD6/SMURF1/SMAD5 | -0.051 | 0.15 | -9999 | 0 | -0.41 | 16 | 16 |
SOSTDC1 | -0.13 | 0.26 | -9999 | 0 | -0.6 | 43 | 43 |
BMP7/BMPR2/BMPR1A-1B | -0.14 | 0.21 | -9999 | 0 | -0.41 | 64 | 64 |
SKI | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP6 (homodimer) | -0.004 | 0.089 | -9999 | 0 | -0.49 | 6 | 6 |
HFE2 | 0.003 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
ZFYVE16 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/CHRD | -0.036 | 0.15 | -9999 | 0 | -0.46 | 17 | 17 |
SMAD5/SMAD5/SMAD4 | -0.053 | 0.15 | -9999 | 0 | -0.41 | 16 | 16 |
MAPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TAK1/TAB family | -0.078 | 0.13 | -9999 | 0 | -0.4 | 18 | 18 |
BMP7 (homodimer) | -0.16 | 0.28 | -9999 | 0 | -0.58 | 56 | 56 |
NUP214 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP6/FETUA | -0.008 | 0.095 | -9999 | 0 | -0.36 | 12 | 12 |
SMAD1/SKI | 0.031 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
SMAD6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/FETUA | -0.015 | 0.11 | -9999 | 0 | -0.4 | 9 | 9 |
MAP3K7IP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GREM1 | -0.13 | 0.25 | -9999 | 0 | -0.56 | 47 | 47 |
BMPR2 (homodimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GADD34/PP1CA | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMPR1A-1B (homodimer) | -0.079 | 0.18 | -9999 | 0 | -0.38 | 46 | 46 |
CHRDL1 | -0.22 | 0.29 | -9999 | 0 | -0.56 | 80 | 80 |
ENDOFIN/SMAD1 | 0.031 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
SMAD6-7/SMURF1/SMAD1 | 0 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
SMAD6/SMURF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BAMBI | -0.062 | 0.2 | -9999 | 0 | -0.56 | 25 | 25 |
SMURF2 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
BMP2-4/CHRDL1 | -0.15 | 0.21 | -9999 | 0 | -0.43 | 56 | 56 |
BMP2-4/GREM1 | -0.091 | 0.19 | -9999 | 0 | -0.44 | 37 | 37 |
SMAD7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMAD8A/SMAD8A/SMAD4 | -0.073 | 0.18 | -9999 | 0 | -0.52 | 22 | 22 |
SMAD1/SMAD6 | 0.031 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
TAK1/SMAD6 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP7 | -0.16 | 0.28 | -9999 | 0 | -0.58 | 56 | 56 |
BMP6 | -0.004 | 0.089 | -9999 | 0 | -0.49 | 6 | 6 |
MAP3K7IP2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/BMPR2/BMPR1A-1B/RGM/SMAD7/SMURF1 | -0.064 | 0.15 | -9999 | 0 | -0.38 | 26 | 26 |
PPM1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMAD1/SMURF2 | 0.03 | 0.031 | -9999 | 0 | -10000 | 0 | 0 |
SMAD7/SMURF1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSPL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP1CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XIAP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP1R15A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/BMPR2/BMPR1A-1B/RGM/FS | -0.13 | 0.25 | -9999 | 0 | -0.55 | 39 | 39 |
CHRD | -0.042 | 0.17 | -9999 | 0 | -0.56 | 18 | 18 |
BMPR2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BMP2-4/BMPR2/BMPR1A-1B/RGM | -0.086 | 0.18 | -9999 | 0 | -0.46 | 26 | 26 |
BMP4 | -0.008 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
FST | -0.08 | 0.21 | -9999 | 0 | -0.54 | 32 | 32 |
BMP2-4/NOG | -0.023 | 0.12 | -9999 | 0 | -0.42 | 8 | 8 |
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 | -0.13 | 0.2 | -9999 | 0 | -0.39 | 64 | 64 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
positive regulation of NF-kappaB transcription factor activity | 0.074 | 0.17 | 0.38 | 44 | -10000 | 0 | 44 |
KIRREL | -0.047 | 0.18 | -10000 | 0 | -0.63 | 16 | 16 |
Nephrin/NEPH1Par3/Par6/Atypical PKCs | -0.074 | 0.18 | -10000 | 0 | -0.38 | 44 | 44 |
PLCG1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
WASL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Nephrin/NEPH1/podocin/CD2AP | -0.05 | 0.14 | -10000 | 0 | -0.39 | 21 | 21 |
ChemicalAbstracts:57-88-5 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Nephrin/NEPH1/podocin/NCK1-2/N-WASP | -0.025 | 0.11 | -10000 | 0 | -0.32 | 20 | 20 |
FYN | -0.049 | 0.13 | -10000 | 0 | -0.37 | 22 | 22 |
mol:Ca2+ | -0.067 | 0.13 | -10000 | 0 | -0.38 | 21 | 21 |
mol:DAG | -0.067 | 0.13 | -10000 | 0 | -0.38 | 21 | 21 |
NPHS2 | -0.02 | 0.085 | -10000 | 0 | -0.44 | 7 | 7 |
mol:IP3 | -0.067 | 0.13 | -10000 | 0 | -0.38 | 21 | 21 |
regulation of endocytosis | -0.039 | 0.13 | -10000 | 0 | -0.34 | 22 | 22 |
Nephrin/NEPH1/podocin/Cholesterol | -0.057 | 0.14 | -10000 | 0 | -0.32 | 34 | 34 |
establishment of cell polarity | -0.074 | 0.17 | -10000 | 0 | -0.38 | 44 | 44 |
Nephrin/NEPH1/podocin/NCK1-2 | -0.037 | 0.13 | -10000 | 0 | -0.35 | 21 | 21 |
Nephrin/NEPH1/beta Arrestin2 | -0.039 | 0.13 | -10000 | 0 | -0.34 | 22 | 22 |
NPHS1 | -0.064 | 0.17 | -10000 | 0 | -0.46 | 29 | 29 |
Nephrin/NEPH1/podocin | -0.049 | 0.14 | -10000 | 0 | -0.37 | 22 | 22 |
TJP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NCK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
heterophilic cell adhesion | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Nephrin/NEPH1/podocin/PLCgamma1 | -0.05 | 0.14 | -10000 | 0 | -0.39 | 21 | 21 |
CD2AP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Nephrin/NEPH1/podocin/GRB2 | -0.05 | 0.14 | -10000 | 0 | -0.39 | 21 | 21 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
homophilic cell adhesion | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRPC6 | -0.061 | 0.17 | -10000 | 0 | -0.44 | 24 | 24 |
cytoskeleton organization | -0.03 | 0.14 | -10000 | 0 | -0.37 | 21 | 21 |
Nephrin/NEPH1 | -0.051 | 0.13 | -10000 | 0 | -0.35 | 21 | 21 |
Nephrin/NEPH1/ZO-1 | -0.067 | 0.13 | -10000 | 0 | -0.38 | 21 | 21 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TGM2 | -0.014 | 0.12 | -10000 | 0 | -0.58 | 8 | 8 |
GNB1/GNG2 | -0.061 | 0.078 | -10000 | 0 | -0.2 | 32 | 32 |
AKT1 | -0.031 | 0.1 | -10000 | 0 | -0.21 | 22 | 22 |
EGF | -0.2 | 0.26 | -10000 | 0 | -0.5 | 79 | 79 |
mol:TXA2 | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
FGR | -0.04 | 0.14 | -10000 | 0 | -0.51 | 9 | 9 |
mol:Ca2+ | -0.062 | 0.14 | -10000 | 0 | -0.32 | 35 | 35 |
LYN | -0.018 | 0.1 | -10000 | 0 | -0.45 | 4 | 4 |
RhoA/GTP | -0.036 | 0.05 | -10000 | 0 | -0.14 | 7 | 7 |
mol:PGI2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SYK | -0.068 | 0.16 | -10000 | 0 | -0.35 | 36 | 36 |
GNG2 | 0.001 | 0.078 | -10000 | 0 | -0.53 | 4 | 4 |
ARRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TP alpha/Gq family/GDP/G beta5/gamma2 | -0.013 | 0.14 | -10000 | 0 | -0.52 | 10 | 10 |
G beta5/gamma2 | -0.078 | 0.11 | -10000 | 0 | -0.28 | 32 | 32 |
PRKCH | -0.068 | 0.16 | -10000 | 0 | -0.36 | 33 | 33 |
DNM1 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
TXA2/TP beta/beta Arrestin3 | -0.015 | 0.04 | -10000 | 0 | -0.28 | 3 | 3 |
mol:GTP | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PTGDR | -0.12 | 0.24 | -10000 | 0 | -0.52 | 49 | 49 |
G12 family/GTP | -0.088 | 0.12 | -10000 | 0 | -0.31 | 36 | 36 |
ADRBK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ADRBK2 | -0.005 | 0.1 | -10000 | 0 | -0.64 | 5 | 5 |
RhoA/GTP/ROCK1 | 0.008 | 0.031 | -10000 | 0 | -0.4 | 1 | 1 |
mol:GDP | 0.056 | 0.13 | 0.35 | 19 | -10000 | 0 | 19 |
mol:NADP | -0.005 | 0.1 | -10000 | 0 | -0.63 | 5 | 5 |
RAB11A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKG1 | -0.066 | 0.2 | -10000 | 0 | -0.58 | 25 | 25 |
mol:IP3 | -0.081 | 0.18 | -10000 | 0 | -0.4 | 35 | 35 |
cell morphogenesis | 0.007 | 0.031 | -10000 | 0 | -0.4 | 1 | 1 |
PLCB2 | -0.12 | 0.24 | -10000 | 0 | -0.55 | 35 | 35 |
mol:cGMP | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
BLK | -0.08 | 0.14 | -10000 | 0 | -0.47 | 11 | 11 |
mol:PDG2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HCK | -0.041 | 0.14 | -10000 | 0 | -0.5 | 8 | 8 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTGIR | -0.009 | 0.1 | -10000 | 0 | -0.5 | 8 | 8 |
PRKCB1 | -0.077 | 0.17 | -10000 | 0 | -0.38 | 36 | 36 |
GNAQ | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
mol:L-citrulline | -0.005 | 0.1 | -10000 | 0 | -0.63 | 5 | 5 |
TXA2/TXA2-R family | -0.12 | 0.24 | -10000 | 0 | -0.55 | 37 | 37 |
LCK | -0.044 | 0.13 | -10000 | 0 | -0.52 | 7 | 7 |
TXA2/TP beta/beta Arrestin3/RAB11/GDP | -0.052 | 0.11 | -10000 | 0 | -0.6 | 3 | 3 |
TXA2-R family/G12 family/GDP/G beta/gamma | 0.007 | 0.047 | -10000 | 0 | -0.32 | 2 | 2 |
TXA2/TP beta/beta Arrestin2/RAB11/GDP | -0.049 | 0.1 | -10000 | 0 | -0.6 | 3 | 3 |
MAPK14 | -0.038 | 0.11 | -10000 | 0 | -0.24 | 27 | 27 |
TGM2/GTP | -0.099 | 0.21 | -10000 | 0 | -0.47 | 35 | 35 |
MAPK11 | -0.04 | 0.12 | -10000 | 0 | -0.24 | 32 | 32 |
ARHGEF1 | -0.03 | 0.088 | -10000 | 0 | -0.19 | 20 | 20 |
GNAI2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
JNK cascade | -0.082 | 0.18 | -10000 | 0 | -0.4 | 37 | 37 |
RAB11/GDP | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
ICAM1 | -0.054 | 0.13 | -10000 | 0 | -0.29 | 31 | 31 |
cAMP biosynthetic process | -0.083 | 0.17 | -10000 | 0 | -0.38 | 36 | 36 |
Gq family/GTP/EBP50 | 0.002 | 0.087 | -10000 | 0 | -0.32 | 8 | 8 |
actin cytoskeleton reorganization | 0.007 | 0.031 | -10000 | 0 | -0.4 | 1 | 1 |
SRC | -0.018 | 0.1 | -10000 | 0 | -0.45 | 4 | 4 |
GNB5 | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
GNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EGF/EGFR | -0.071 | 0.13 | -10000 | 0 | -0.35 | 24 | 24 |
VCAM1 | -0.066 | 0.15 | -10000 | 0 | -0.33 | 37 | 37 |
TP beta/Gq family/GDP/G beta5/gamma2 | -0.013 | 0.14 | -10000 | 0 | -0.52 | 10 | 10 |
platelet activation | -0.053 | 0.15 | -10000 | 0 | -0.31 | 35 | 35 |
PGI2/IP | -0.007 | 0.076 | -10000 | 0 | -0.36 | 8 | 8 |
PRKACA | -0.051 | 0.13 | -10000 | 0 | -0.34 | 24 | 24 |
Gq family/GDP/G beta5/gamma2 | -0.017 | 0.13 | -10000 | 0 | -0.48 | 11 | 11 |
TXA2/TP beta/beta Arrestin2 | -0.016 | 0.075 | -10000 | 0 | -0.58 | 3 | 3 |
positive regulation of NF-kappaB transcription factor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TBXA2R | -0.043 | 0.13 | -10000 | 0 | -0.33 | 24 | 24 |
mol:DAG | -0.088 | 0.19 | -10000 | 0 | -0.43 | 35 | 35 |
EGFR | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
TXA2/TP alpha | -0.12 | 0.23 | -10000 | 0 | -0.53 | 36 | 36 |
Gq family/GTP | -0.014 | 0.087 | -10000 | 0 | -0.27 | 14 | 14 |
YES1 | -0.018 | 0.1 | -10000 | 0 | -0.45 | 4 | 4 |
GNAI2/GTP | -0.053 | 0.1 | -10000 | 0 | -0.53 | 4 | 4 |
PGD2/DP | -0.09 | 0.17 | -10000 | 0 | -0.38 | 49 | 49 |
SLC9A3R1 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
FYN | -0.021 | 0.11 | -10000 | 0 | -0.46 | 5 | 5 |
mol:NO | -0.005 | 0.1 | -10000 | 0 | -0.63 | 5 | 5 |
GNA15 | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
PGK/cGMP | -0.044 | 0.14 | -10000 | 0 | -0.37 | 30 | 30 |
RhoA/GDP | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
TP alpha/TGM2/GDP/G beta/gamma | -0.036 | 0.15 | -10000 | 0 | -0.66 | 6 | 6 |
NOS3 | -0.005 | 0.1 | -10000 | 0 | -0.64 | 5 | 5 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCA | -0.07 | 0.16 | -10000 | 0 | -0.36 | 33 | 33 |
PRKCB | -0.09 | 0.19 | -10000 | 0 | -0.4 | 43 | 43 |
PRKCE | -0.065 | 0.16 | -10000 | 0 | -0.36 | 33 | 33 |
PRKCD | -0.073 | 0.17 | -10000 | 0 | -0.38 | 35 | 35 |
PRKCG | -0.11 | 0.2 | -10000 | 0 | -0.44 | 38 | 38 |
muscle contraction | -0.11 | 0.23 | -10000 | 0 | -0.51 | 37 | 37 |
PRKCZ | -0.068 | 0.16 | -10000 | 0 | -0.35 | 34 | 34 |
ARR3 | -0.002 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
TXA2/TP beta | -0.046 | 0.12 | -10000 | 0 | -0.54 | 5 | 5 |
PRKCQ | -0.091 | 0.19 | -10000 | 0 | -0.39 | 41 | 41 |
MAPKKK cascade | -0.1 | 0.22 | -10000 | 0 | -0.49 | 37 | 37 |
SELE | -0.081 | 0.17 | -10000 | 0 | -0.38 | 39 | 39 |
TP beta/GNAI2/GDP/G beta/gamma | -0.024 | 0.13 | -10000 | 0 | -0.78 | 3 | 3 |
ROCK1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
GNA14 | -0.011 | 0.12 | -10000 | 0 | -0.6 | 7 | 7 |
chemotaxis | -0.13 | 0.26 | -10000 | 0 | -0.6 | 38 | 38 |
GNA12 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNA13 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNA11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GTP | 0.005 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PPAP2A | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
LAT2 | -0.071 | 0.18 | -10000 | 0 | -0.48 | 20 | 20 |
AP1 | -0.12 | 0.22 | -10000 | 0 | -0.63 | 24 | 24 |
mol:PIP3 | -0.1 | 0.24 | -10000 | 0 | -0.6 | 27 | 27 |
IKBKB | -0.046 | 0.14 | 0.16 | 5 | -0.33 | 28 | 33 |
AKT1 | -0.059 | 0.17 | -10000 | 0 | -0.55 | 10 | 10 |
IKBKG | -0.045 | 0.14 | -10000 | 0 | -0.34 | 26 | 26 |
MS4A2 | -0.099 | 0.23 | -10000 | 0 | -0.56 | 37 | 37 |
mol:Sphingosine-1-phosphate | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K1 | -0.064 | 0.2 | -10000 | 0 | -0.51 | 24 | 24 |
mol:Ca2+ | -0.069 | 0.18 | -10000 | 0 | -0.42 | 27 | 27 |
LYN | 0.009 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
CBLB | -0.067 | 0.17 | -10000 | 0 | -0.44 | 22 | 22 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RasGAP/p62DOK | 0.01 | 0.061 | -10000 | 0 | -0.36 | 3 | 3 |
positive regulation of cell migration | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
INPP5D | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
PLD2 | -0.092 | 0.2 | -10000 | 0 | -0.42 | 33 | 33 |
PTPN13 | -0.11 | 0.21 | -10000 | 0 | -0.57 | 21 | 21 |
PTPN11 | 0.008 | 0.009 | -10000 | 0 | -10000 | 0 | 0 |
GO:0007205 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of mast cell degranulation | -0.031 | 0.14 | -10000 | 0 | -0.37 | 14 | 14 |
SYK | 0.009 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
LAT/PLCgamma1/GRB2/SLP76/GADs | -0.14 | 0.23 | -10000 | 0 | -0.63 | 27 | 27 |
LAT | -0.08 | 0.19 | -10000 | 0 | -0.49 | 24 | 24 |
PAK2 | -0.081 | 0.23 | -10000 | 0 | -0.59 | 24 | 24 |
NFATC2 | -0.12 | 0.23 | -10000 | 0 | -0.69 | 23 | 23 |
HRAS | -0.097 | 0.25 | -10000 | 0 | -0.67 | 24 | 24 |
GAB2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
PLA2G1B | 0.034 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
Fc epsilon R1 | -0.14 | 0.22 | -10000 | 0 | -0.47 | 49 | 49 |
Antigen/IgE/Fc epsilon R1 | -0.13 | 0.2 | -10000 | 0 | -0.43 | 49 | 49 |
mol:GDP | -0.11 | 0.28 | -10000 | 0 | -0.72 | 25 | 25 |
JUN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
mol:Ca++ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.026 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
Antigen/IgE/Fc epsilon R1/LYN/SYK | -0.078 | 0.18 | -10000 | 0 | -0.42 | 30 | 30 |
CHUK | -0.045 | 0.14 | 0.16 | 5 | -0.33 | 28 | 33 |
KLRG1 | -0.072 | 0.17 | -10000 | 0 | -0.43 | 23 | 23 |
VAV1 | -0.098 | 0.22 | -10000 | 0 | -0.55 | 28 | 28 |
calcium-dependent protein kinase C activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CBL | -0.067 | 0.17 | -10000 | 0 | -0.47 | 19 | 19 |
negative regulation of mast cell degranulation | -0.073 | 0.17 | -10000 | 0 | -0.42 | 24 | 24 |
BTK | -0.11 | 0.29 | -10000 | 0 | -0.78 | 23 | 23 |
Fc epsilon R1/FcgammaRIIB/SHIP/RasGAP/p62DOK | -0.14 | 0.27 | -10000 | 0 | -0.59 | 40 | 40 |
GAB2/PI3K/SHP2 | -0.1 | 0.16 | -10000 | 0 | -0.58 | 11 | 11 |
Antigen/IgE/Fc epsilon R1/LYN/SYK/WIP | -0.07 | 0.18 | -10000 | 0 | -0.56 | 14 | 14 |
RAF1 | 0.025 | 0.027 | -10000 | 0 | -10000 | 0 | 0 |
Fc epsilon R1/FcgammaRIIB/SHIP | -0.19 | 0.27 | -10000 | 0 | -0.54 | 57 | 57 |
FCER1G | -0.017 | 0.13 | -10000 | 0 | -0.58 | 10 | 10 |
FCER1A | -0.1 | 0.23 | -10000 | 0 | -0.54 | 38 | 38 |
Antigen/IgE/Fc epsilon R1/Fyn | -0.12 | 0.19 | -10000 | 0 | -0.41 | 49 | 49 |
MAPK3 | 0.033 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.033 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | -0.006 | 0.066 | -10000 | 0 | -0.38 | 1 | 1 |
DUSP1 | -0.012 | 0.11 | -10000 | 0 | -0.49 | 9 | 9 |
NF-kappa-B/RelA | -0.045 | 0.069 | -10000 | 0 | -0.23 | 9 | 9 |
actin cytoskeleton reorganization | -0.067 | 0.18 | -10000 | 0 | -0.57 | 13 | 13 |
mol:Glucocorticoid Dexamethasone | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | -0.12 | 0.21 | -10000 | 0 | -0.61 | 23 | 23 |
FER | -0.068 | 0.17 | -10000 | 0 | -0.47 | 19 | 19 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ITK | -0.056 | 0.14 | -10000 | 0 | -0.5 | 14 | 14 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLCG1 | -0.11 | 0.27 | -10000 | 0 | -0.73 | 24 | 24 |
cytokine secretion | -0.033 | 0.05 | -10000 | 0 | -10000 | 0 | 0 |
SPHK1 | -0.097 | 0.21 | -10000 | 0 | -0.45 | 39 | 39 |
PTK2 | -0.07 | 0.18 | -10000 | 0 | -0.6 | 13 | 13 |
NTAL/PLCgamma1/GRB2/SLP76/GADs | -0.14 | 0.23 | -10000 | 0 | -0.63 | 26 | 26 |
EDG1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:DAG | -0.092 | 0.23 | -10000 | 0 | -0.56 | 27 | 27 |
MAP2K2 | 0.03 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | 0.03 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KLRG1/SHP2 | -0.085 | 0.14 | -10000 | 0 | -0.43 | 19 | 19 |
MAP2K4 | 0.009 | 0.065 | -10000 | 0 | -0.87 | 1 | 1 |
Fc epsilon R1/FcgammaRIIB | -0.19 | 0.28 | -10000 | 0 | -0.56 | 58 | 58 |
mol:Choline | -0.091 | 0.19 | -10000 | 0 | -0.42 | 33 | 33 |
SHC/Grb2/SOS1 | -0.081 | 0.15 | -10000 | 0 | -0.52 | 13 | 13 |
FYN | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
DOK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PXN | -0.059 | 0.17 | -10000 | 0 | -0.54 | 13 | 13 |
HCLS1 | -0.079 | 0.2 | -10000 | 0 | -0.49 | 26 | 26 |
PRKCB | -0.078 | 0.2 | -10000 | 0 | -0.49 | 28 | 28 |
FCGR2B | -0.11 | 0.23 | -10000 | 0 | -0.54 | 41 | 41 |
IGHE | -0.003 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
KLRG1/SHIP | -0.074 | 0.17 | -10000 | 0 | -0.43 | 24 | 24 |
LCP2 | -0.015 | 0.12 | -10000 | 0 | -0.56 | 9 | 9 |
PLA2G4A | -0.16 | 0.24 | -10000 | 0 | -0.46 | 58 | 58 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Phosphatidic acid | -0.091 | 0.19 | -10000 | 0 | -0.42 | 33 | 33 |
IKK complex | -0.021 | 0.11 | 0.16 | 5 | -0.26 | 19 | 24 |
WIPF1 | -0.003 | 0.091 | -10000 | 0 | -0.55 | 5 | 5 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
IKK alpha homodimer | -0.061 | 0.17 | -9999 | 0 | -0.46 | 14 | 14 |
NF kappa B1 p50/RelA/I kappa B alpha | -0.034 | 0.16 | -9999 | 0 | -0.59 | 6 | 6 |
alphaV/beta3 Integrin/Osteopontin/Src | -0.12 | 0.18 | -9999 | 0 | -0.38 | 60 | 60 |
AP1 | -0.074 | 0.22 | -9999 | 0 | -0.64 | 14 | 14 |
ILK | -0.074 | 0.18 | -9999 | 0 | -0.47 | 15 | 15 |
bone resorption | -0.04 | 0.16 | -9999 | 0 | -0.54 | 5 | 5 |
PTK2B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PYK2/p130Cas | -0.055 | 0.17 | -9999 | 0 | -0.43 | 14 | 14 |
ITGAV | 0.015 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CD44/Rho Family GTPase/ROCK2 | 0.015 | 0.035 | -9999 | 0 | -0.47 | 1 | 1 |
alphaV/beta3 Integrin/Osteopontin | -0.12 | 0.18 | -9999 | 0 | -0.43 | 38 | 38 |
MAP3K1 | -0.075 | 0.18 | -9999 | 0 | -0.39 | 38 | 38 |
JUN | 0.008 | 0.046 | -9999 | 0 | -0.63 | 1 | 1 |
MAPK3 | -0.059 | 0.18 | -9999 | 0 | -0.47 | 14 | 14 |
MAPK1 | -0.059 | 0.18 | -9999 | 0 | -0.57 | 8 | 8 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | -0.064 | 0.18 | -9999 | 0 | -0.37 | 38 | 38 |
ITGB3 | -0.015 | 0.13 | -9999 | 0 | -0.57 | 10 | 10 |
NFKBIA | -0.049 | 0.18 | -9999 | 0 | -0.65 | 6 | 6 |
FOS | -0.026 | 0.14 | -9999 | 0 | -0.55 | 13 | 13 |
CD44 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
CHUK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLAU | -0.05 | 0.22 | -9999 | 0 | -0.93 | 6 | 6 |
NF kappa B1 p50/RelA | -0.077 | 0.13 | -9999 | 0 | -0.59 | 6 | 6 |
BCAR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV beta3 Integrin | -0.016 | 0.095 | -9999 | 0 | -0.41 | 10 | 10 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SYK | -0.074 | 0.18 | -9999 | 0 | -0.39 | 38 | 38 |
VAV3 | -0.13 | 0.21 | -9999 | 0 | -0.38 | 69 | 69 |
MAP3K14 | -0.073 | 0.18 | -9999 | 0 | -0.39 | 38 | 38 |
ROCK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SPP1 | -0.16 | 0.26 | -9999 | 0 | -0.53 | 60 | 60 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.11 | 0.19 | -9999 | 0 | -0.5 | 18 | 18 |
MMP2 | -0.079 | 0.23 | -9999 | 0 | -0.64 | 20 | 20 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ACADVL | -0.22 | 0.34 | -10000 | 0 | -0.93 | 18 | 18 |
PCK1 | -0.24 | 0.45 | -10000 | 0 | -1.3 | 23 | 23 |
HNF4A | -0.27 | 0.39 | -10000 | 0 | -1 | 24 | 24 |
KCNJ11 | -0.23 | 0.37 | -10000 | 0 | -0.99 | 19 | 19 |
AKT1 | -0.12 | 0.16 | -10000 | 0 | -0.42 | 8 | 8 |
response to starvation | -0.013 | 0.029 | -10000 | 0 | -10000 | 0 | 0 |
DLK1 | -0.23 | 0.35 | -10000 | 0 | -0.99 | 17 | 17 |
NKX2-1 | -0.17 | 0.35 | -10000 | 0 | -1.2 | 14 | 14 |
ACADM | -0.22 | 0.34 | -10000 | 0 | -0.93 | 18 | 18 |
TAT | -0.13 | 0.2 | -10000 | 0 | -0.66 | 10 | 10 |
CEBPB | 0.007 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
CEBPA | -0.007 | 0.1 | -10000 | 0 | -0.64 | 5 | 5 |
TTR | -0.29 | 0.44 | -10000 | 0 | -1.1 | 38 | 38 |
PKLR | -0.42 | 0.5 | -10000 | 0 | -1 | 67 | 67 |
APOA1 | -0.27 | 0.39 | -10000 | 0 | -1 | 23 | 23 |
CPT1C | -0.25 | 0.37 | -10000 | 0 | -0.94 | 26 | 26 |
ALAS1 | -0.088 | 0.16 | -10000 | 0 | -10000 | 0 | 0 |
TFRC | -0.15 | 0.25 | -10000 | 0 | -0.95 | 5 | 5 |
FOXF1 | 0.009 | 0.13 | 0.28 | 3 | -0.58 | 7 | 10 |
NF1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HNF1A (dimer) | 0.005 | 0.064 | -10000 | 0 | -0.44 | 2 | 2 |
CPT1A | -0.22 | 0.34 | -10000 | 0 | -0.93 | 18 | 18 |
HMGCS1 | -0.23 | 0.34 | -10000 | 0 | -0.95 | 19 | 19 |
NR3C1 | -0.019 | 0.12 | -10000 | 0 | -0.52 | 9 | 9 |
CPT1B | -0.25 | 0.37 | -10000 | 0 | -0.99 | 24 | 24 |
chromatin remodeling | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SP1 | 0.01 | 0.037 | -10000 | 0 | -10000 | 0 | 0 |
GCK | -0.24 | 0.36 | -10000 | 0 | -1 | 20 | 20 |
CREB1 | -0.004 | 0.054 | -10000 | 0 | -10000 | 0 | 0 |
IGFBP1 | -0.14 | 0.2 | -10000 | 0 | -0.58 | 14 | 14 |
PDX1 | -0.14 | 0.33 | -10000 | 0 | -1.4 | 10 | 10 |
UCP2 | -0.24 | 0.35 | -10000 | 0 | -0.95 | 21 | 21 |
ALDOB | -0.37 | 0.51 | -10000 | 0 | -1.1 | 50 | 50 |
AFP | -0.049 | 0.14 | -10000 | 0 | -0.57 | 3 | 3 |
BDH1 | -0.23 | 0.36 | -10000 | 0 | -0.92 | 23 | 23 |
HADH | -0.22 | 0.35 | -10000 | 0 | -1 | 15 | 15 |
F2 | -0.3 | 0.44 | -10000 | 0 | -1.1 | 27 | 27 |
HNF1A | 0.005 | 0.064 | -10000 | 0 | -0.44 | 2 | 2 |
G6PC | -0.022 | 0.13 | -10000 | 0 | -0.73 | 3 | 3 |
SLC2A2 | -0.14 | 0.23 | -10000 | 0 | -0.63 | 12 | 12 |
INS | -0.001 | 0.043 | -10000 | 0 | -0.42 | 1 | 1 |
FOXA1 | -0.065 | 0.22 | 0.28 | 1 | -0.6 | 26 | 27 |
FOXA3 | -0.024 | 0.13 | -10000 | 0 | -0.63 | 6 | 6 |
FOXA2 | -0.26 | 0.4 | -10000 | 0 | -0.97 | 26 | 26 |
ABCC8 | -0.24 | 0.37 | -10000 | 0 | -0.99 | 22 | 22 |
ALB | -0.054 | 0.15 | -10000 | 0 | -0.52 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PCK2 | 0.026 | 0.075 | 0.34 | 2 | -10000 | 0 | 2 |
SMARCC2 | 0.013 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
SMARCC1 | 0.013 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
TBX21 | -0.14 | 0.29 | -10000 | 0 | -0.71 | 33 | 33 |
SUMO2 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 (dimer) | 0.012 | 0.06 | -10000 | 0 | -0.45 | 3 | 3 |
FKBP4 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
FKBP5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GR alpha/HSP90/FKBP51/HSP90 | 0.091 | 0.1 | 0.32 | 13 | -10000 | 0 | 13 |
PRL | -0.084 | 0.15 | -10000 | 0 | -0.6 | 6 | 6 |
cortisol/GR alpha (dimer)/TIF2 | 0.2 | 0.23 | 0.53 | 47 | -10000 | 0 | 47 |
RELA | -0.039 | 0.099 | -10000 | 0 | -0.32 | 7 | 7 |
FGG | 0.15 | 0.2 | 0.49 | 24 | -0.4 | 1 | 25 |
GR beta/TIF2 | 0.088 | 0.12 | 0.34 | 15 | -0.42 | 1 | 16 |
IFNG | -0.3 | 0.39 | -10000 | 0 | -0.89 | 43 | 43 |
apoptosis | 0.02 | 0.17 | 0.47 | 12 | -0.56 | 1 | 13 |
CREB1 | 0.012 | 0.019 | -10000 | 0 | -10000 | 0 | 0 |
histone acetylation | -0.046 | 0.13 | -10000 | 0 | -0.38 | 15 | 15 |
BGLAP | -0.056 | 0.12 | -10000 | 0 | -0.57 | 2 | 2 |
GR/PKAc | 0.073 | 0.13 | 0.31 | 11 | -0.36 | 7 | 18 |
NF kappa B1 p50/RelA | -0.076 | 0.19 | -10000 | 0 | -0.53 | 16 | 16 |
SMARCD1 | 0.013 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
MDM2 | 0.084 | 0.088 | 0.26 | 20 | -10000 | 0 | 20 |
GATA3 | -0.024 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
AKT1 | 0.002 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
CSF2 | -0.23 | 0.38 | -10000 | 0 | -1.1 | 28 | 28 |
GSK3B | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
NR1I3 | 0.032 | 0.2 | 0.47 | 9 | -0.9 | 4 | 13 |
CSN2 | 0.13 | 0.15 | 0.39 | 25 | -10000 | 0 | 25 |
BRG1/BAF155/BAF170/BAF60A | 0.035 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
NFATC1 | -0.027 | 0.14 | -10000 | 0 | -0.52 | 14 | 14 |
POU2F1 | 0.002 | 0.07 | -10000 | 0 | -0.63 | 2 | 2 |
CDKN1A | -0.015 | 0.18 | -10000 | 0 | -1.4 | 2 | 2 |
response to stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to UV | 0.001 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
SFN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
GR alpha/HSP90/FKBP51/HSP90/14-3-3 | 0.09 | 0.1 | 0.32 | 12 | -0.34 | 1 | 13 |
prolactin receptor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EGR1 | 0.014 | 0.23 | 0.46 | 9 | -0.82 | 8 | 17 |
JUN | -0.16 | 0.18 | -10000 | 0 | -0.48 | 25 | 25 |
IL4 | -0.098 | 0.16 | -10000 | 0 | -0.5 | 13 | 13 |
CDK5R1 | 0.01 | 0.031 | -10000 | 0 | -0.41 | 1 | 1 |
PRKACA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cortisol/GR alpha (monomer)/AP-1 | -0.12 | 0.21 | 0.22 | 13 | -0.5 | 27 | 40 |
GR alpha/HSP90/FKBP51/HSP90/PP5C | 0.093 | 0.099 | 0.32 | 12 | -10000 | 0 | 12 |
cortisol/GR alpha (monomer) | 0.24 | 0.29 | 0.63 | 49 | -10000 | 0 | 49 |
NCOA2 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
response to hypoxia | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.08 | 0.16 | -10000 | 0 | -0.61 | 13 | 13 |
AP-1/NFAT1-c-4 | -0.28 | 0.31 | -10000 | 0 | -0.7 | 44 | 44 |
AFP | -0.11 | 0.14 | -10000 | 0 | -0.56 | 1 | 1 |
SUV420H1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IRF1 | 0.13 | 0.14 | 0.49 | 9 | -10000 | 0 | 9 |
TP53 | -0.019 | 0.17 | -10000 | 0 | -0.6 | 15 | 15 |
PPP5C | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KRT17 | -0.39 | 0.48 | -10000 | 0 | -1 | 58 | 58 |
KRT14 | -0.11 | 0.16 | -10000 | 0 | -0.5 | 13 | 13 |
TBP | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.032 | 0.043 | -10000 | 0 | -10000 | 0 | 0 |
HDAC1 | 0.01 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
HDAC2 | 0.026 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
AP-1 | -0.28 | 0.31 | -10000 | 0 | -0.71 | 44 | 44 |
MAPK14 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
MAPK10 | -0.057 | 0.18 | -10000 | 0 | -0.52 | 25 | 25 |
MAPK11 | 0.007 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
KRT5 | -0.29 | 0.36 | -10000 | 0 | -0.93 | 33 | 33 |
interleukin-1 receptor activity | 0.014 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
NCOA1 | 0.015 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 | 0.012 | 0.06 | -10000 | 0 | -0.46 | 3 | 3 |
CGA | -0.074 | 0.13 | -10000 | 0 | -0.46 | 10 | 10 |
NF kappa B1 p50/RelA/Cbp/cortisol/GR alpha (monomer)/HDAC2 | 0.14 | 0.19 | 0.43 | 44 | -0.59 | 1 | 45 |
MAPK3 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
ICAM1 | -0.16 | 0.24 | -10000 | 0 | -0.66 | 24 | 24 |
NFKB1 | -0.039 | 0.099 | -10000 | 0 | -0.32 | 7 | 7 |
MAPK8 | -0.14 | 0.17 | -10000 | 0 | -0.47 | 22 | 22 |
MAPK9 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
cortisol/GR alpha (dimer) | 0.015 | 0.17 | 0.48 | 12 | -0.58 | 1 | 13 |
BAX | -0.002 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
POMC | -0.19 | 0.39 | -10000 | 0 | -1.4 | 14 | 14 |
EP300 | 0.03 | 0.065 | -10000 | 0 | -0.61 | 1 | 1 |
cortisol/GR alpha (dimer)/p53 | 0.18 | 0.26 | 0.55 | 44 | -0.42 | 3 | 47 |
proteasomal ubiquitin-dependent protein catabolic process | 0.058 | 0.068 | 0.23 | 9 | -10000 | 0 | 9 |
SGK1 | 0.068 | 0.13 | -10000 | 0 | -1.4 | 1 | 1 |
IL13 | -0.2 | 0.22 | -10000 | 0 | -0.74 | 13 | 13 |
IL6 | -0.3 | 0.46 | -10000 | 0 | -0.96 | 50 | 50 |
PRKACG | 0.004 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
IL5 | -0.17 | 0.19 | -10000 | 0 | -0.67 | 11 | 11 |
IL2 | -0.22 | 0.24 | -10000 | 0 | -0.73 | 18 | 18 |
CDK5 | 0.012 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
PRKACB | -0.017 | 0.13 | -10000 | 0 | -0.61 | 9 | 9 |
HSP90AA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL8 | -0.26 | 0.42 | -10000 | 0 | -0.97 | 39 | 39 |
CDK5R1/CDK5 | 0.016 | 0.024 | -10000 | 0 | -0.28 | 1 | 1 |
NF kappa B1 p50/RelA/PKAc | -0.051 | 0.17 | -10000 | 0 | -0.57 | 9 | 9 |
cortisol/GR alpha (dimer)/Hsp90/FKBP52/HSP90 | 0.2 | 0.22 | 0.51 | 46 | -10000 | 0 | 46 |
SMARCA4 | 0.013 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
chromatin remodeling | 0.14 | 0.14 | 0.38 | 26 | -0.4 | 1 | 27 |
NF kappa B1 p50/RelA/Cbp | -0.02 | 0.18 | -10000 | 0 | -0.57 | 8 | 8 |
JUN (dimer) | -0.16 | 0.18 | -10000 | 0 | -0.48 | 25 | 25 |
YWHAH | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VIPR1 | -0.098 | 0.24 | -10000 | 0 | -0.74 | 17 | 17 |
NR3C1 | 0.14 | 0.18 | 0.46 | 28 | -10000 | 0 | 28 |
NR4A1 | -0.039 | 0.16 | -10000 | 0 | -0.48 | 20 | 20 |
TIF2/SUV420H1 | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
MAPKKK cascade | 0.02 | 0.17 | 0.47 | 12 | -0.56 | 1 | 13 |
cortisol/GR alpha (dimer)/Src-1 | 0.22 | 0.23 | 0.54 | 47 | -10000 | 0 | 47 |
PBX1 | -0.018 | 0.13 | -10000 | 0 | -0.63 | 8 | 8 |
POU1F1 | -0.003 | 0.045 | -10000 | 0 | -0.51 | 1 | 1 |
SELE | -0.29 | 0.45 | -10000 | 0 | -1 | 42 | 42 |
cortisol/GR alpha/BRG1/BAF155/BAF170/BAF60A | 0.14 | 0.14 | 0.38 | 26 | -0.4 | 1 | 27 |
cortisol/GR alpha (monomer)/Hsp90/FKBP52/HSP90 | 0.2 | 0.22 | 0.51 | 46 | -10000 | 0 | 46 |
mol:cortisol | 0.14 | 0.18 | 0.35 | 57 | -10000 | 0 | 57 |
MMP1 | -0.3 | 0.46 | -10000 | 0 | -1.3 | 30 | 30 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
LAT/GRAP2/SLP76/HPK1 | -0.067 | 0.23 | -9999 | 0 | -0.58 | 27 | 27 |
MAP4K1 | -0.065 | 0.2 | -9999 | 0 | -0.58 | 25 | 25 |
MAP3K8 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCB | -0.068 | 0.2 | -9999 | 0 | -0.55 | 27 | 27 |
DBNL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CRKL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K1 | -0.026 | 0.17 | -9999 | 0 | -0.56 | 14 | 14 |
JUN | -0.049 | 0.23 | -9999 | 0 | -0.76 | 17 | 17 |
MAP3K7 | -0.026 | 0.17 | -9999 | 0 | -0.56 | 14 | 14 |
GRAP2 | -0.033 | 0.16 | -9999 | 0 | -0.56 | 15 | 15 |
CRK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K4 | -0.019 | 0.17 | -9999 | 0 | -0.59 | 12 | 12 |
LAT | -0.015 | 0.12 | -9999 | 0 | -0.5 | 10 | 10 |
LCP2 | -0.015 | 0.12 | -9999 | 0 | -0.56 | 9 | 9 |
MAPK8 | -0.057 | 0.24 | -9999 | 0 | -0.79 | 17 | 17 |
LAT/GRAP2/SLP76/HPK1/HIP-55/CRK family | -0.035 | 0.18 | -9999 | 0 | -0.51 | 19 | 19 |
LAT/GRAP2/SLP76/HPK1/HIP-55 | -0.058 | 0.22 | -9999 | 0 | -0.55 | 27 | 27 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GNB1/GNG2 | -0.029 | 0.13 | -9999 | 0 | -0.38 | 15 | 15 |
NF kappa B1 p50/RelA/I kappa B alpha | -0.013 | 0.1 | -9999 | 0 | -0.36 | 3 | 3 |
AP1 | -0.093 | 0.14 | -9999 | 0 | -0.36 | 32 | 32 |
mol:PIP3 | -0.067 | 0.12 | -9999 | 0 | -0.51 | 5 | 5 |
AKT1 | 0.014 | 0.083 | -9999 | 0 | -0.43 | 1 | 1 |
PTK2B | -0.015 | 0.086 | -9999 | 0 | -0.29 | 7 | 7 |
RHOA | 0.015 | 0.046 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CB | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.015 | 0.095 | -9999 | 0 | -0.32 | 2 | 2 |
MAGI3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
apoptosis | -0.064 | 0.15 | -9999 | 0 | -0.33 | 37 | 37 |
HRAS/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of microtubule depolymerization | -0.057 | 0.14 | -9999 | 0 | -0.36 | 23 | 23 |
NF kappa B1 p50/RelA | -0.068 | 0.12 | -9999 | 0 | -0.47 | 6 | 6 |
endothelial cell migration | -0.066 | 0.22 | -9999 | 0 | -0.54 | 31 | 31 |
ADCY4 | -0.066 | 0.2 | -9999 | 0 | -0.53 | 22 | 22 |
ADCY5 | -0.12 | 0.25 | -9999 | 0 | -0.6 | 34 | 34 |
ADCY6 | -0.064 | 0.19 | -9999 | 0 | -0.51 | 22 | 22 |
ADCY7 | -0.064 | 0.19 | -9999 | 0 | -0.51 | 22 | 22 |
ADCY1 | -0.08 | 0.21 | -9999 | 0 | -0.53 | 26 | 26 |
ADCY2 | -0.099 | 0.24 | -9999 | 0 | -0.57 | 33 | 33 |
ADCY3 | -0.064 | 0.19 | -9999 | 0 | -0.51 | 22 | 22 |
ADCY8 | -0.068 | 0.19 | -9999 | 0 | -0.52 | 22 | 22 |
ADCY9 | -0.066 | 0.19 | -9999 | 0 | -0.51 | 23 | 23 |
GSK3B | -0.008 | 0.082 | -9999 | 0 | -0.31 | 3 | 3 |
arachidonic acid secretion | -0.062 | 0.19 | -9999 | 0 | -0.5 | 22 | 22 |
GNG2 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
TRIP6 | -0.004 | 0.097 | -9999 | 0 | -0.44 | 9 | 9 |
GNAO1 | -0.097 | 0.2 | -9999 | 0 | -0.43 | 41 | 41 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NFKBIA | -0.02 | 0.11 | -9999 | 0 | -0.41 | 3 | 3 |
GAB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
lamellipodium assembly | -0.08 | 0.25 | -9999 | 0 | -0.9 | 16 | 16 |
JUN | 0.008 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
LPA/LPA2/NHERF2 | -0.007 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
TIAM1 | -0.095 | 0.3 | -9999 | 0 | -1.1 | 16 | 16 |
PIK3R1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mol:IP3 | -0.016 | 0.097 | -9999 | 0 | -0.32 | 2 | 2 |
PLCB3 | 0.017 | 0.026 | -9999 | 0 | -10000 | 0 | 0 |
FOS | -0.026 | 0.14 | -9999 | 0 | -0.55 | 13 | 13 |
positive regulation of mitosis | -0.062 | 0.19 | -9999 | 0 | -0.5 | 22 | 22 |
LPA/LPA1-2-3 | -0.073 | 0.16 | -9999 | 0 | -0.4 | 25 | 25 |
mol:Ca ++ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JNK cascade | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCAR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
stress fiber formation | -0.026 | 0.11 | -9999 | 0 | -0.37 | 7 | 7 |
GNAZ | -0.041 | 0.15 | -9999 | 0 | -0.38 | 28 | 28 |
EGFR/PI3K-beta/Gab1 | -0.07 | 0.12 | -9999 | 0 | -0.54 | 5 | 5 |
positive regulation of dendritic cell cytokine production | -0.088 | 0.15 | -9999 | 0 | -0.4 | 25 | 25 |
LPA/LPA2/MAGI-3 | -0.004 | 0.025 | -9999 | 0 | -10000 | 0 | 0 |
ARHGEF1 | -0.011 | 0.11 | -9999 | 0 | -0.34 | 13 | 13 |
GNAI2 | -0.029 | 0.13 | -9999 | 0 | -0.35 | 25 | 25 |
GNAI3 | -0.029 | 0.13 | -9999 | 0 | -0.35 | 25 | 25 |
GNAI1 | -0.041 | 0.16 | -9999 | 0 | -0.4 | 27 | 27 |
LPA/LPA3 | -0.065 | 0.14 | -9999 | 0 | -0.37 | 32 | 32 |
LPA/LPA2 | -0.004 | 0.034 | -9999 | 0 | -10000 | 0 | 0 |
LPA/LPA1 | -0.06 | 0.15 | -9999 | 0 | -0.41 | 25 | 25 |
HB-EGF/EGFR | -0.051 | 0.15 | -9999 | 0 | -0.4 | 24 | 24 |
HBEGF | -0.061 | 0.17 | -9999 | 0 | -0.39 | 38 | 38 |
mol:DAG | -0.016 | 0.097 | -9999 | 0 | -0.32 | 2 | 2 |
cAMP biosynthetic process | -0.09 | 0.22 | -9999 | 0 | -0.51 | 33 | 33 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNB1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
LYN | -0.02 | 0.11 | -9999 | 0 | -0.34 | 13 | 13 |
GNAQ | -0.033 | 0.1 | -9999 | 0 | -0.33 | 15 | 15 |
LPAR2 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
LPAR3 | -0.076 | 0.2 | -9999 | 0 | -0.5 | 32 | 32 |
LPAR1 | -0.044 | 0.17 | -9999 | 0 | -0.64 | 13 | 13 |
IL8 | -0.11 | 0.21 | -9999 | 0 | -0.48 | 36 | 36 |
PTK2 | -0.058 | 0.15 | -9999 | 0 | -0.37 | 25 | 25 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP3 | -0.064 | 0.15 | -9999 | 0 | -0.33 | 37 | 37 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
PLCG1 | -0.033 | 0.11 | -9999 | 0 | -0.33 | 17 | 17 |
PLD2 | -0.058 | 0.15 | -9999 | 0 | -0.37 | 25 | 25 |
G12/G13 | -0.019 | 0.12 | -9999 | 0 | -0.37 | 13 | 13 |
PI3K-beta | -0.029 | 0.076 | -9999 | 0 | -0.43 | 2 | 2 |
cell migration | -0.049 | 0.083 | -9999 | 0 | -0.27 | 17 | 17 |
SLC9A3R2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PXN | -0.027 | 0.11 | -9999 | 0 | -0.37 | 7 | 7 |
HRAS/GTP | -0.064 | 0.19 | -9999 | 0 | -0.52 | 22 | 22 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MMP9 | -0.089 | 0.22 | -9999 | 0 | -0.56 | 34 | 34 |
PRKCE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCD | -0.009 | 0.093 | -9999 | 0 | -0.34 | 1 | 1 |
Gi(beta/gamma) | -0.061 | 0.19 | -9999 | 0 | -0.5 | 22 | 22 |
mol:LPA | -0.014 | 0.054 | -9999 | 0 | -0.2 | 12 | 12 |
TRIP6/p130 Cas/FAK1/Paxillin | -0.074 | 0.13 | -9999 | 0 | -0.53 | 5 | 5 |
MAPKKK cascade | -0.062 | 0.19 | -9999 | 0 | -0.5 | 22 | 22 |
contractile ring contraction involved in cytokinesis | 0.015 | 0.046 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA14 | -0.041 | 0.12 | -9999 | 0 | -0.35 | 19 | 19 |
GNA15 | -0.044 | 0.12 | -9999 | 0 | -0.34 | 21 | 21 |
GNA12 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA13 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPT | -0.059 | 0.14 | -9999 | 0 | -0.37 | 23 | 23 |
GNA11 | -0.029 | 0.1 | -9999 | 0 | -0.33 | 13 | 13 |
Rac1/GTP | -0.067 | 0.27 | -9999 | 0 | -0.96 | 16 | 16 |
MMP2 | -0.067 | 0.22 | -9999 | 0 | -0.54 | 31 | 31 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MAP4K1 | -0.044 | 0.16 | -10000 | 0 | -0.34 | 35 | 35 |
CRKL | -0.014 | 0.14 | -10000 | 0 | -0.42 | 16 | 16 |
HRAS | -0.028 | 0.16 | -10000 | 0 | -0.5 | 9 | 9 |
mol:PIP3 | -0.023 | 0.13 | -10000 | 0 | -0.4 | 16 | 16 |
SPRED1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SPRED2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GAB1 | -0.021 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
FOXO3 | -0.007 | 0.13 | -10000 | 0 | -0.38 | 16 | 16 |
AKT1 | -0.015 | 0.13 | -10000 | 0 | -0.41 | 16 | 16 |
BAD | -0.007 | 0.13 | -10000 | 0 | -0.38 | 16 | 16 |
megakaryocyte differentiation | -0.11 | 0.2 | -10000 | 0 | -0.41 | 47 | 47 |
GSK3B | -0.007 | 0.13 | -10000 | 0 | -0.38 | 16 | 16 |
RAF1 | -0.014 | 0.13 | -10000 | 0 | -0.4 | 9 | 9 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAT3 | -0.021 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
STAT1 | -0.064 | 0.32 | -10000 | 0 | -0.96 | 19 | 19 |
HRAS/SPRED1 | -0.016 | 0.13 | -10000 | 0 | -0.4 | 9 | 9 |
cell proliferation | -0.02 | 0.14 | -10000 | 0 | -0.44 | 16 | 16 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TEC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RPS6KB1 | -0.02 | 0.14 | -10000 | 0 | -0.44 | 16 | 16 |
HRAS/SPRED2 | -0.016 | 0.13 | -10000 | 0 | -0.4 | 9 | 9 |
LYN/TEC/p62DOK | -0.03 | 0.13 | -10000 | 0 | -0.41 | 16 | 16 |
MAPK3 | 0.002 | 0.099 | -10000 | 0 | -0.27 | 9 | 9 |
STAP1 | -0.07 | 0.2 | -10000 | 0 | -0.46 | 32 | 32 |
GRAP2 | -0.033 | 0.16 | -10000 | 0 | -0.56 | 15 | 15 |
JAK2 | -0.077 | 0.26 | -10000 | 0 | -0.8 | 19 | 19 |
STAT1 (dimer) | -0.062 | 0.31 | -10000 | 0 | -0.94 | 19 | 19 |
mol:Gleevec | 0 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
GRB2/SOCS1/VAV1 | -0.065 | 0.17 | -10000 | 0 | -0.49 | 18 | 18 |
actin filament polymerization | -0.024 | 0.14 | -10000 | 0 | -0.42 | 18 | 18 |
LYN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAP1/STAT5A (dimer) | -0.071 | 0.24 | -10000 | 0 | -0.61 | 25 | 25 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CBL/CRKL/GRB2 | 0 | 0.12 | -10000 | 0 | -0.37 | 16 | 16 |
PI3K | -0.009 | 0.14 | -10000 | 0 | -0.42 | 16 | 16 |
PTEN | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
SCF/KIT/EPO/EPOR | -0.075 | 0.38 | -10000 | 0 | -1.3 | 16 | 16 |
MAPK8 | -0.021 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
STAT3 (dimer) | -0.02 | 0.14 | -10000 | 0 | -0.44 | 16 | 16 |
positive regulation of transcription | 0.006 | 0.084 | -10000 | 0 | -0.24 | 2 | 2 |
mol:GDP | -0.04 | 0.17 | -10000 | 0 | -0.43 | 23 | 23 |
PIK3C2B | -0.021 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
CBL/CRKL | -0.006 | 0.13 | -10000 | 0 | -0.39 | 16 | 16 |
FER | -0.022 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
SH2B3 | -0.021 | 0.14 | -10000 | 0 | -0.45 | 16 | 16 |
PDPK1 | -0.015 | 0.12 | -10000 | 0 | -0.37 | 16 | 16 |
SNAI2 | -0.032 | 0.16 | -10000 | 0 | -0.47 | 19 | 19 |
positive regulation of cell proliferation | -0.04 | 0.23 | -10000 | 0 | -0.7 | 19 | 19 |
KITLG | 0.01 | 0.05 | -10000 | 0 | -0.67 | 1 | 1 |
cell motility | -0.04 | 0.23 | -10000 | 0 | -0.7 | 19 | 19 |
PTPN6 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
EPOR | 0.002 | 0.15 | -10000 | 0 | -1.5 | 1 | 1 |
STAT5A (dimer) | -0.029 | 0.2 | -10000 | 0 | -0.57 | 19 | 19 |
SOCS1 | 0 | 0.086 | -10000 | 0 | -0.58 | 4 | 4 |
cell migration | 0.056 | 0.17 | 0.4 | 30 | -10000 | 0 | 30 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EPO | 0.008 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
VAV1 | -0.052 | 0.19 | -10000 | 0 | -0.6 | 20 | 20 |
GRB10 | -0.023 | 0.14 | -10000 | 0 | -0.44 | 17 | 17 |
PTPN11 | 0.012 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
SCF/KIT | -0.029 | 0.15 | -10000 | 0 | -0.45 | 18 | 18 |
GO:0007205 | 0 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | -0.002 | 0.11 | -10000 | 0 | -0.3 | 9 | 9 |
CBL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KIT | -0.094 | 0.39 | -10000 | 0 | -1.3 | 16 | 16 |
MAP2K2 | -0.002 | 0.11 | -10000 | 0 | -0.3 | 9 | 9 |
SHC/Grb2/SOS1 | -0.03 | 0.13 | -10000 | 0 | -0.41 | 16 | 16 |
STAT5A | -0.031 | 0.2 | -10000 | 0 | -0.59 | 19 | 19 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to radiation | -0.031 | 0.16 | -10000 | 0 | -0.46 | 19 | 19 |
SHC/GRAP2 | -0.015 | 0.12 | -10000 | 0 | -0.4 | 15 | 15 |
PTPRO | -0.11 | 0.21 | -10000 | 0 | -0.42 | 47 | 47 |
SH2B2 | -0.025 | 0.14 | -10000 | 0 | -0.43 | 18 | 18 |
DOK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MATK | -0.057 | 0.17 | -10000 | 0 | -0.41 | 30 | 30 |
CREBBP | 0.029 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
BCL2 | -0.011 | 0.2 | -10000 | 0 | -1.1 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Syndecan-2/Fibronectin | -0.062 | 0.18 | -9999 | 0 | -0.36 | 42 | 42 |
EPHB2 | -0.002 | 0.092 | -9999 | 0 | -0.64 | 4 | 4 |
Syndecan-2/TACI | -0.061 | 0.16 | -9999 | 0 | -0.42 | 25 | 25 |
LAMA1 | -0.063 | 0.2 | -9999 | 0 | -0.56 | 25 | 25 |
Syndecan-2/alpha2 ITGB1 | 0.01 | 0.09 | -9999 | 0 | -0.35 | 10 | 10 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-2/CASK | -0.001 | 0.074 | -9999 | 0 | -0.38 | 7 | 7 |
ITGA5 | -0.014 | 0.11 | -9999 | 0 | -0.48 | 10 | 10 |
BAX | 0.022 | 0.067 | -9999 | 0 | -10000 | 0 | 0 |
EPB41 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
positive regulation of cell-cell adhesion | 0.007 | 0.067 | -9999 | 0 | -0.36 | 6 | 6 |
LAMA3 | -0.01 | 0.11 | -9999 | 0 | -0.52 | 8 | 8 |
EZR | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CAV2 | -0.003 | 0.082 | -9999 | 0 | -0.45 | 6 | 6 |
Syndecan-2/MMP2 | -0.028 | 0.16 | -9999 | 0 | -0.52 | 14 | 14 |
RP11-540L11.1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha2 ITGB1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
dendrite morphogenesis | -0.001 | 0.093 | -9999 | 0 | -0.38 | 11 | 11 |
Syndecan-2/GM-CSF | -0.087 | 0.16 | -9999 | 0 | -0.4 | 28 | 28 |
determination of left/right symmetry | 0.001 | 0.086 | -9999 | 0 | -0.44 | 7 | 7 |
Syndecan-2/PKC delta | 0.008 | 0.074 | -9999 | 0 | -0.37 | 7 | 7 |
GNB2L1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | -0.07 | 0.15 | -9999 | 0 | -0.35 | 28 | 28 |
MAPK1 | -0.07 | 0.15 | -9999 | 0 | -0.35 | 28 | 28 |
Syndecan-2/RACK1 | 0.015 | 0.064 | -9999 | 0 | -0.33 | 6 | 6 |
NF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FGFR/FGF/Syndecan-2 | 0.001 | 0.086 | -9999 | 0 | -0.44 | 7 | 7 |
ITGA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.016 | 0.075 | -9999 | 0 | -0.39 | 6 | 6 |
Syndecan-2/alpha2/beta1 Integrin | -0.019 | 0.12 | -9999 | 0 | -0.33 | 23 | 23 |
Syndecan-2/Kininogen | -0.059 | 0.15 | -9999 | 0 | -0.42 | 19 | 19 |
ITGB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.021 | 0.061 | -9999 | 0 | -0.31 | 6 | 6 |
Syndecan-2/CASK/Protein 4.1 | 0.005 | 0.073 | -9999 | 0 | -0.36 | 7 | 7 |
extracellular matrix organization | -0.002 | 0.11 | -9999 | 0 | -0.43 | 10 | 10 |
actin cytoskeleton reorganization | -0.062 | 0.18 | -9999 | 0 | -0.36 | 42 | 42 |
Syndecan-2/Caveolin-2/Ras | 0.008 | 0.088 | -9999 | 0 | -0.41 | 6 | 6 |
Syndecan-2/Laminin alpha3 | -0.006 | 0.1 | -9999 | 0 | -0.37 | 13 | 13 |
Syndecan-2/RasGAP | 0.02 | 0.062 | -9999 | 0 | -0.31 | 6 | 6 |
alpha5/beta1 Integrin | -0.001 | 0.081 | -9999 | 0 | -0.34 | 10 | 10 |
PRKCD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-2 dimer | -0.001 | 0.094 | -9999 | 0 | -0.38 | 11 | 11 |
GO:0007205 | 0.003 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DNA mediated transformation | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-2/RasGAP/Src | 0.027 | 0.06 | -9999 | 0 | -0.3 | 6 | 6 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SDCBP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF13B | -0.099 | 0.22 | -9999 | 0 | -0.53 | 39 | 39 |
RASA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha2/beta1 Integrin | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-2/Synbindin | 0.008 | 0.074 | -9999 | 0 | -0.39 | 6 | 6 |
TGFB1 | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
CASP3 | 0.014 | 0.073 | -9999 | 0 | -0.35 | 7 | 7 |
FN1 | -0.1 | 0.23 | -9999 | 0 | -0.54 | 40 | 40 |
Syndecan-2/IL8 | -0.065 | 0.16 | -9999 | 0 | -0.33 | 48 | 48 |
SDC2 | 0.001 | 0.087 | -9999 | 0 | -0.44 | 7 | 7 |
KNG1 | -0.097 | 0.21 | -9999 | 0 | -0.48 | 41 | 41 |
Syndecan-2/Neurofibromin | 0.008 | 0.074 | -9999 | 0 | -0.37 | 7 | 7 |
TRAPPC4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSF2 | -0.14 | 0.24 | -9999 | 0 | -0.5 | 57 | 57 |
Syndecan-2/TGFB1 | -0.002 | 0.11 | -9999 | 0 | -0.43 | 10 | 10 |
Syndecan-2/Syntenin/PI-4-5-P2 | 0.007 | 0.068 | -9999 | 0 | -0.36 | 6 | 6 |
Syndecan-2/Ezrin | 0.015 | 0.068 | -9999 | 0 | -0.35 | 6 | 6 |
PRKACA | 0.016 | 0.068 | -9999 | 0 | -0.35 | 6 | 6 |
angiogenesis | -0.065 | 0.16 | -9999 | 0 | -0.33 | 48 | 48 |
MMP2 | -0.047 | 0.18 | -9999 | 0 | -0.56 | 20 | 20 |
IL8 | -0.11 | 0.23 | -9999 | 0 | -0.52 | 43 | 43 |
calcineurin-NFAT signaling pathway | -0.061 | 0.16 | -9999 | 0 | -0.42 | 25 | 25 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
STX1A | 0.004 | 0.043 | -9999 | 0 | -0.29 | 4 | 4 |
UniProt:P19321 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RIMS1/UNC13B | -0.044 | 0.14 | -9999 | 0 | -0.35 | 31 | 31 |
STXBP1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
ACh/CHRNA1 | -0.04 | 0.12 | -9999 | 0 | -0.38 | 20 | 20 |
RAB3GAP2/RIMS1/UNC13B | -0.031 | 0.12 | -9999 | 0 | -0.39 | 12 | 12 |
mol:Ca2+ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UniProt:P30996 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UniProt:Q60393 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CST086 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RIMS1 | -0.073 | 0.19 | -9999 | 0 | -0.49 | 31 | 31 |
mol:ACh | -0.012 | 0.043 | -9999 | 0 | -0.13 | 17 | 17 |
RAB3GAP2 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
STX1A/SNAP25/VAMP2 | -0.065 | 0.11 | -9999 | 0 | -0.33 | 16 | 16 |
UniProt:P10844 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
muscle contraction | -0.04 | 0.12 | -9999 | 0 | -0.38 | 20 | 20 |
UNC13B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CHRNA1 | -0.048 | 0.18 | -9999 | 0 | -0.56 | 20 | 20 |
UniProt:P10845 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ACh/Synaptotagmin 1 | -0.099 | 0.18 | -9999 | 0 | -0.42 | 45 | 45 |
SNAP25 | -0.037 | 0.093 | -9999 | 0 | -0.2 | 40 | 40 |
VAMP2 | 0.006 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SYT1 | -0.13 | 0.27 | -9999 | 0 | -0.61 | 45 | 45 |
UniProt:Q00496 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STXIA/STXBP1 | -0.002 | 0.08 | -9999 | 0 | -0.34 | 10 | 10 |
STX1A/SNAP25 fragment 1/VAMP2 | -0.065 | 0.11 | -9999 | 0 | -0.33 | 16 | 16 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CRKL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP/Tiam1 | -0.044 | 0.12 | -10000 | 0 | -0.4 | 8 | 8 |
NT3 (dimer)/TRKC | -0.082 | 0.18 | -10000 | 0 | -0.39 | 47 | 47 |
NT3 (dimer)/TRKB | -0.2 | 0.24 | -10000 | 0 | -0.48 | 65 | 65 |
SHC/Grb2/SOS1/GAB1/PI3K | 0.033 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAPGEF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BDNF | -0.034 | 0.16 | -10000 | 0 | -0.54 | 16 | 16 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DYNLT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NTRK1 | -0.057 | 0.18 | -10000 | 0 | -0.53 | 24 | 24 |
NTRK2 | -0.18 | 0.26 | -10000 | 0 | -0.5 | 73 | 73 |
NTRK3 | -0.077 | 0.2 | -10000 | 0 | -0.51 | 32 | 32 |
NT-4/5 (dimer)/TRKB | -0.19 | 0.23 | -10000 | 0 | -0.48 | 59 | 59 |
neuron apoptosis | 0.18 | 0.23 | 0.49 | 53 | -10000 | 0 | 53 |
SHC 2-3/Grb2 | -0.2 | 0.26 | -10000 | 0 | -0.55 | 53 | 53 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC2 | -0.17 | 0.24 | -10000 | 0 | -0.57 | 40 | 40 |
SHC3 | -0.19 | 0.26 | -10000 | 0 | -0.61 | 40 | 40 |
STAT3 (dimer) | 0.019 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT3 (dimer)/TRKA | -0.13 | 0.22 | -10000 | 0 | -0.46 | 50 | 50 |
RIN/GDP | -0.014 | 0.074 | -10000 | 0 | -0.24 | 4 | 4 |
GIPC1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
KRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNAJA3 | -0.1 | 0.16 | -10000 | 0 | -0.4 | 27 | 27 |
RIN/GTP | 0.001 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
CCND1 | 0.027 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAGED1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTPN11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RICS | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT-4/5 (dimer) | -0.014 | 0.089 | -10000 | 0 | -0.42 | 9 | 9 |
SHC/GRB2/SOS1 | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGF (dimer)/TRKA/MATK | -0.1 | 0.21 | -10000 | 0 | -0.45 | 45 | 45 |
TRKA/NEDD4-2 | -0.033 | 0.14 | -10000 | 0 | -0.38 | 24 | 24 |
ELMO1 | -0.005 | 0.087 | -10000 | 0 | -0.45 | 7 | 7 |
RhoG/GTP/ELMO1/DOCK1 | 0.006 | 0.053 | -10000 | 0 | -0.26 | 7 | 7 |
NGF | -0.053 | 0.18 | -10000 | 0 | -0.53 | 23 | 23 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DOCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GAB2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
RIT2 | 0.001 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
RIT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNM1 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SH2B1 (homopentamer) | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoG/GTP | -0.11 | 0.16 | -10000 | 0 | -0.39 | 31 | 31 |
mol:GDP | -0.022 | 0.1 | -10000 | 0 | -0.35 | 5 | 5 |
NGF (dimer) | -0.053 | 0.18 | -10000 | 0 | -0.53 | 23 | 23 |
RhoG/GDP | -0.003 | 0.062 | -10000 | 0 | -0.32 | 7 | 7 |
RIT1/GDP | -0.009 | 0.075 | -10000 | 0 | -0.24 | 3 | 3 |
TIAM1 | -0.075 | 0.2 | -10000 | 0 | -0.53 | 31 | 31 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BDNF (dimer)/TRKB | -0.12 | 0.19 | -10000 | 0 | -0.44 | 40 | 40 |
KIDINS220/CRKL/C3G | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC/RasGAP | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS2 family/SHP2 | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC/GRB2/SOS1/GAB1 | 0.031 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RIT1/GTP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NT3 (dimer) | -0.036 | 0.16 | -10000 | 0 | -0.56 | 16 | 16 |
RAP1/GDP | -0.028 | 0.048 | -10000 | 0 | -0.21 | 1 | 1 |
KIDINS220/CRKL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BDNF (dimer) | -0.034 | 0.16 | -10000 | 0 | -0.54 | 16 | 16 |
ubiquitin-dependent protein catabolic process | -0.059 | 0.16 | -10000 | 0 | -0.41 | 28 | 28 |
Schwann cell development | -0.039 | 0.034 | -10000 | 0 | -10000 | 0 | 0 |
EHD4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS2 family/GRB2/SOS1 | 0.031 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS2 family/SHP2/CRK family/C3G/GAB2 | 0.035 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
RAP1B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDC42/GTP | -0.16 | 0.18 | -10000 | 0 | -0.48 | 32 | 32 |
ABL1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SH2B family/GRB2/SOS1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Rap1/GTP | -0.044 | 0.062 | -10000 | 0 | -10000 | 0 | 0 |
STAT3 | 0.019 | 0 | -10000 | 0 | -10000 | 0 | 0 |
axon guidance | -0.15 | 0.18 | -10000 | 0 | -0.46 | 32 | 32 |
MAPK3 | -0.086 | 0.19 | -10000 | 0 | -0.4 | 45 | 45 |
MAPK1 | -0.086 | 0.19 | -10000 | 0 | -0.4 | 45 | 45 |
CDC42/GDP | -0.009 | 0.075 | -10000 | 0 | -0.24 | 3 | 3 |
NTF3 | -0.036 | 0.16 | -10000 | 0 | -0.57 | 16 | 16 |
NTF4 | -0.014 | 0.089 | -10000 | 0 | -0.42 | 9 | 9 |
NGF (dimer)/TRKA/FAIM | -0.061 | 0.16 | -10000 | 0 | -0.42 | 29 | 29 |
PI3K | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FAIM | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
GAB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RASGRF1 | -0.14 | 0.18 | -10000 | 0 | -0.42 | 42 | 42 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MCF2L | -0.061 | 0.16 | -10000 | 0 | -0.4 | 25 | 25 |
RGS19 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
CDC42 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP | -0.003 | 0.07 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GDP | -0.009 | 0.075 | -10000 | 0 | -0.24 | 3 | 3 |
NGF (dimer)/TRKA/GRIT | -0.067 | 0.16 | -10000 | 0 | -0.36 | 42 | 42 |
neuron projection morphogenesis | -0.07 | 0.16 | -10000 | 0 | -0.64 | 4 | 4 |
NGF (dimer)/TRKA/NEDD4-2 | -0.059 | 0.16 | -10000 | 0 | -0.42 | 28 | 28 |
MAP2K1 | 0.035 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NGFR | -0.12 | 0.24 | -10000 | 0 | -0.52 | 48 | 48 |
NGF (dimer)/TRKA/GIPC/GAIP | -0.034 | 0.13 | -10000 | 0 | -0.57 | 3 | 3 |
RAS family/GTP/PI3K | 0.028 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FRS2 family/SHP2/GRB2/SOS1 | 0.036 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB2/SOS1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCI | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
ChemicalAbstracts:146-91-8 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPKKK cascade | -0.12 | 0.22 | -10000 | 0 | -0.65 | 25 | 25 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRKA/c-Abl | -0.033 | 0.14 | -10000 | 0 | -0.38 | 24 | 24 |
SQSTM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BDNF (dimer)/TRKB/GIPC | -0.11 | 0.18 | -10000 | 0 | -0.4 | 41 | 41 |
NGF (dimer)/TRKA/p62/Atypical PKCs | -0.039 | 0.14 | -10000 | 0 | -0.35 | 29 | 29 |
MATK | -0.06 | 0.18 | -10000 | 0 | -0.52 | 26 | 26 |
NEDD4L | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GDP | -0.024 | 0.044 | -10000 | 0 | -10000 | 0 | 0 |
NGF (dimer)/TRKA | -0.11 | 0.17 | -10000 | 0 | -0.34 | 58 | 58 |
Rac1/GTP | -0.1 | 0.12 | -10000 | 0 | -0.35 | 22 | 22 |
FRS2 family/SHP2/CRK family | 0.036 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TOP1 | -0.03 | 0.14 | -10000 | 0 | -0.34 | 25 | 25 |
ACTA1 | -0.053 | 0.18 | -10000 | 0 | -0.45 | 25 | 25 |
NUMA1 | -0.03 | 0.14 | -10000 | 0 | -0.34 | 25 | 25 |
SPTAN1 | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
LIMK1 | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
BIRC3 | -0.016 | 0.12 | -10000 | 0 | -0.48 | 11 | 11 |
BIRC2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BAX | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP10 | -0.061 | 0.18 | -10000 | 0 | -0.46 | 26 | 26 |
CRMA | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
XIAP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTK2 | -0.03 | 0.14 | -10000 | 0 | -0.34 | 25 | 25 |
DIABLO | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptotic nuclear changes | -0.046 | 0.17 | -10000 | 0 | -0.43 | 25 | 25 |
response to UV | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GSN | -0.052 | 0.18 | -10000 | 0 | -0.45 | 26 | 26 |
MADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TFAP2A | -0.098 | 0.21 | -10000 | 0 | -0.55 | 33 | 33 |
BID | -0.024 | 0.093 | -10000 | 0 | -0.24 | 26 | 26 |
MAP3K1 | -0.01 | 0.061 | -10000 | 0 | -0.22 | 3 | 3 |
TRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
APAF-1/Pro-Caspase 9 | 0.018 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:Activated DNA | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARHGDIB | -0.049 | 0.17 | -10000 | 0 | -0.44 | 26 | 26 |
CASP9 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNA repair | 0.005 | 0.052 | -10000 | 0 | -0.2 | 2 | 2 |
neuron apoptosis | 0.015 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
mol:NAD | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNA fragmentation during apoptosis | -0.038 | 0.17 | -10000 | 0 | -0.42 | 25 | 25 |
APAF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP6 | -0.002 | 0.083 | -10000 | 0 | -0.46 | 1 | 1 |
TRAF2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ICAD/CAD | -0.039 | 0.17 | -10000 | 0 | -0.42 | 25 | 25 |
CASP7 | 0.009 | 0.053 | 0.31 | 3 | -10000 | 0 | 3 |
KRT18 | 0.005 | 0.047 | -10000 | 0 | -0.55 | 1 | 1 |
apoptosis | -0.031 | 0.15 | -10000 | 0 | -0.4 | 19 | 19 |
DFFA | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
DFFB | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
PARP1 | -0.005 | 0.053 | 0.2 | 2 | -10000 | 0 | 2 |
actin filament polymerization | 0.043 | 0.16 | 0.4 | 26 | -10000 | 0 | 26 |
TNF | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
CYCS | -0.014 | 0.07 | -10000 | 0 | -0.22 | 6 | 6 |
SATB1 | -0.022 | 0.12 | -10000 | 0 | -0.41 | 5 | 5 |
SLK | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
p15 BID/BAX | -0.015 | 0.083 | -10000 | 0 | -0.29 | 5 | 5 |
CASP2 | 0.028 | 0.062 | -10000 | 0 | -0.39 | 2 | 2 |
JNK cascade | 0.01 | 0.061 | 0.22 | 3 | -10000 | 0 | 3 |
CASP3 | -0.056 | 0.18 | -10000 | 0 | -0.47 | 25 | 25 |
LMNB2 | 0.023 | 0.052 | -10000 | 0 | -0.31 | 2 | 2 |
RIPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP4 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
Mammalian IAPs/DIABLO | 0.015 | 0.065 | -10000 | 0 | -0.35 | 3 | 3 |
negative regulation of DNA binding | -0.096 | 0.21 | -10000 | 0 | -0.55 | 33 | 33 |
stress fiber formation | -0.046 | 0.17 | -10000 | 0 | -0.43 | 25 | 25 |
GZMB | -0.081 | 0.2 | -10000 | 0 | -0.44 | 42 | 42 |
CASP1 | -0.003 | 0.079 | -10000 | 0 | -0.37 | 8 | 8 |
LMNB1 | 0.023 | 0.052 | -10000 | 0 | -0.31 | 2 | 2 |
APP | 0.015 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
TNFRSF1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP8 | 0.01 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VIM | -0.035 | 0.15 | 0.22 | 1 | -0.37 | 25 | 26 |
LMNA | 0.023 | 0.052 | -10000 | 0 | -0.31 | 2 | 2 |
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD/PIDD | 0.023 | 0.066 | -10000 | 0 | -0.42 | 2 | 2 |
LRDD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SREBF1 | -0.047 | 0.17 | -10000 | 0 | -0.44 | 25 | 25 |
APAF-1/Caspase 9 | -0.006 | 0.034 | -10000 | 0 | -10000 | 0 | 0 |
nuclear fragmentation during apoptosis | -0.029 | 0.14 | -10000 | 0 | -0.34 | 25 | 25 |
CFL2 | -0.044 | 0.17 | -10000 | 0 | -0.41 | 26 | 26 |
GAS2 | -0.091 | 0.2 | -10000 | 0 | -0.44 | 39 | 39 |
positive regulation of apoptosis | 0.026 | 0.052 | -10000 | 0 | -0.3 | 2 | 2 |
PRF1 | -0.038 | 0.16 | -10000 | 0 | -0.52 | 18 | 18 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HDAC1 | 0.014 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
AES | 0.018 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
FBXW11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
LRP6/FZD1 | 0.016 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
SMAD4 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
DKK2 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 48 | 48 |
TLE1 | 0.011 | 0.071 | -10000 | 0 | -0.64 | 2 | 2 |
MACF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.063 | 0.082 | 0.3 | 3 | -10000 | 0 | 3 |
WIF1 | -0.2 | 0.26 | -10000 | 0 | -0.51 | 76 | 76 |
beta catenin/RanBP3 | 0.053 | 0.15 | 0.39 | 29 | -10000 | 0 | 29 |
KREMEN2 | -0.034 | 0.14 | -10000 | 0 | -0.45 | 19 | 19 |
DKK1 | -0.19 | 0.26 | -10000 | 0 | -0.51 | 74 | 74 |
beta catenin/beta TrCP1 | 0.067 | 0.077 | 0.28 | 3 | -10000 | 0 | 3 |
FZD1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
AXIN2 | -0.19 | 0.5 | -10000 | 0 | -1.4 | 27 | 27 |
AXIN1 | 0.013 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
Axin1/APC/GSK3/beta catenin | 0.022 | 0.036 | -10000 | 0 | -10000 | 0 | 0 |
beta catenin/TCF/CtBP/CBP/TLE1/AES/SMAD4 | 0.054 | 0.11 | -10000 | 0 | -0.51 | 3 | 3 |
Axin1/APC/GSK3 | 0.053 | 0.069 | 0.23 | 9 | -10000 | 0 | 9 |
Axin1/APC/GSK3/beta catenin/Macf1 | 0.057 | 0.043 | -10000 | 0 | -10000 | 0 | 0 |
HNF1A | 0.015 | 0.05 | -10000 | 0 | -0.59 | 1 | 1 |
CTBP1 | 0.018 | 0.027 | -10000 | 0 | -10000 | 0 | 0 |
MYC | -0.031 | 0.2 | -10000 | 0 | -1.5 | 3 | 3 |
RANBP3 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
DKK2/LRP6/Kremen 2 | -0.093 | 0.17 | -10000 | 0 | -0.42 | 29 | 29 |
NKD1 | -0.16 | 0.26 | -10000 | 0 | -0.52 | 62 | 62 |
TCF4 | -0.004 | 0.12 | -10000 | 0 | -0.6 | 7 | 7 |
TCF3 | 0.018 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
WNT1/LRP6/FZD1/Axin1 | 0.019 | 0.04 | -10000 | 0 | -10000 | 0 | 0 |
Ran/GTP | 0.01 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
CtBP/CBP/TCF/TLE1/AES | 0.048 | 0.18 | 0.45 | 26 | -0.52 | 1 | 27 |
LEF1 | -0.015 | 0.14 | -10000 | 0 | -0.57 | 11 | 11 |
DVL1 | 0.057 | 0.037 | -10000 | 0 | -10000 | 0 | 0 |
CSNK2A1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
beta catenin/TCF/CtBP/CBP/TLE1/AES | 0.032 | 0.13 | -10000 | 0 | -0.54 | 4 | 4 |
DKK1/LRP6/Kremen 2 | -0.13 | 0.19 | -10000 | 0 | -0.43 | 40 | 40 |
LRP6 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
CSNK1A1 | 0.018 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
NLK | 0.011 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
CCND1 | -0.012 | 0.087 | -10000 | 0 | -0.53 | 1 | 1 |
WNT1 | -0.004 | 0.074 | -10000 | 0 | -0.42 | 6 | 6 |
GSK3A | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
GSK3B | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
FRAT1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PPP2R5D | 0.11 | 0.12 | 0.27 | 62 | -10000 | 0 | 62 |
APC | 0.026 | 0.045 | -10000 | 0 | -0.33 | 1 | 1 |
WNT1/LRP6/FZD1 | 0.082 | 0.089 | 0.24 | 30 | -10000 | 0 | 30 |
CREBBP | 0.018 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ADCY4 | 0.012 | 0.04 | -9999 | 0 | -0.29 | 3 | 3 |
ADCY5 | -0.092 | 0.17 | -9999 | 0 | -0.34 | 59 | 59 |
ADCY6 | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ADCY7 | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ADCY1 | -0.018 | 0.1 | -9999 | 0 | -0.28 | 23 | 23 |
ADCY2 | -0.041 | 0.14 | -9999 | 0 | -0.37 | 29 | 29 |
ADCY3 | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ADCY8 | 0.008 | 0.018 | -9999 | 0 | -0.24 | 1 | 1 |
PRKCE | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ADCY9 | 0.015 | 0.03 | -9999 | 0 | -0.4 | 1 | 1 |
mol:DAG | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cAMP biosynthetic process | -0.027 | 0.089 | -9999 | 0 | -0.38 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
DYNC1H1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VLDLR | -0.072 | 0.21 | -9999 | 0 | -0.56 | 28 | 28 |
LRPAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NUDC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/LRP8 | -0.093 | 0.17 | -9999 | 0 | -0.4 | 33 | 33 |
CaM/Ca2+ | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KATNA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GO:0030286 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ABL1 | -0.077 | 0.15 | -9999 | 0 | -0.36 | 33 | 33 |
IQGAP1/CaM | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAB1 | -0.072 | 0.19 | -9999 | 0 | -0.49 | 31 | 31 |
IQGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLA2G7 | -0.042 | 0.17 | -9999 | 0 | -0.6 | 17 | 17 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DYNLT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LRPAP1/LRP8 | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
UniProt:Q4QZ09 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CLIP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDK5R1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
LIS1/Poliovirus Protein 3A | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDK5R2 | -0.072 | 0.19 | -9999 | 0 | -0.5 | 31 | 31 |
mol:PP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/VLDLR/DAB1 | -0.19 | 0.22 | -9999 | 0 | -0.47 | 60 | 60 |
YWHAE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NDEL1/14-3-3 E | -0.064 | 0.15 | -9999 | 0 | -0.45 | 11 | 11 |
MAP1B | -0.015 | 0.056 | -9999 | 0 | -0.33 | 4 | 4 |
RAC1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
p35/CDK5 | -0.056 | 0.14 | -9999 | 0 | -0.42 | 2 | 2 |
RELN | -0.17 | 0.26 | -9999 | 0 | -0.52 | 65 | 65 |
PAFAH/LIS1 | -0.011 | 0.11 | -9999 | 0 | -0.39 | 14 | 14 |
LIS1/CLIP170 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain | -0.07 | 0.1 | -9999 | 0 | -0.4 | 6 | 6 |
RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 | -0.1 | 0.16 | -9999 | 0 | -0.32 | 55 | 55 |
GO:0005869 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NDEL1 | -0.074 | 0.16 | -9999 | 0 | -0.48 | 12 | 12 |
LIS1/IQGAP1 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAFAH1B1 | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAFAH1B3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAFAH1B2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP1B/LIS1/Dynein heavy chain | 0.012 | 0.04 | -9999 | 0 | -10000 | 0 | 0 |
NDEL1/Katanin 60/Dynein heavy chain | -0.056 | 0.15 | -9999 | 0 | -0.49 | 6 | 6 |
LRP8 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
NDEL1/Katanin 60 | -0.064 | 0.15 | -9999 | 0 | -0.45 | 11 | 11 |
P39/CDK5 | -0.097 | 0.18 | -9999 | 0 | -0.51 | 16 | 16 |
LIS1/NudC/Dynein intermediate chain/microtubule organizing center | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDK5 | -0.065 | 0.14 | -9999 | 0 | -0.33 | 33 | 33 |
PPP2R5D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LIS1/CLIP170/Dynein Complex/Dynactin Complex | 0.021 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK2A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELN/VLDLR/DAB1/LIS1 | -0.15 | 0.2 | -9999 | 0 | -0.39 | 60 | 60 |
RELN/VLDLR | -0.12 | 0.19 | -9999 | 0 | -0.4 | 47 | 47 |
CDC42 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ANTXR1 | -0.06 | 0.19 | -10000 | 0 | -0.56 | 24 | 24 |
ANTXR2 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
negative regulation of myeloid dendritic cell antigen processing and presentation | -0.009 | 0.024 | -10000 | 0 | -0.07 | 25 | 25 |
monocyte activation | -0.033 | 0.16 | -10000 | 0 | -0.54 | 14 | 14 |
MAP2K2 | -0.004 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | -0.008 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K7 | -0.008 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K6 | -0.014 | 0.053 | -10000 | 0 | -0.34 | 4 | 4 |
CYAA | -0.027 | 0.11 | -10000 | 0 | -0.29 | 25 | 25 |
MAP2K4 | -0.009 | 0.032 | -10000 | 0 | -0.35 | 1 | 1 |
IL1B | -0.04 | 0.11 | -10000 | 0 | -0.28 | 30 | 30 |
Channel | -0.027 | 0.11 | -10000 | 0 | -0.31 | 25 | 25 |
NLRP1 | -0.017 | 0.056 | -10000 | 0 | -0.27 | 7 | 7 |
CALM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
negative regulation of phagocytosis | -0.01 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of endothelial cell proliferation | 0.009 | 0.024 | 0.07 | 25 | -10000 | 0 | 25 |
MAPK3 | -0.008 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | -0.008 | 0.02 | -10000 | 0 | -10000 | 0 | 0 |
PGR | -0.055 | 0.12 | -10000 | 0 | -0.32 | 31 | 31 |
PA/Cellular Receptors | -0.03 | 0.12 | -10000 | 0 | -0.34 | 25 | 25 |
apoptosis | -0.009 | 0.024 | -10000 | 0 | -0.07 | 25 | 25 |
LOC728358 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Lethal toxin (unfolded) | -0.024 | 0.1 | -10000 | 0 | -0.29 | 25 | 25 |
macrophage activation | 0.008 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
TNF | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
VCAM1 | -0.033 | 0.16 | -10000 | 0 | -0.54 | 14 | 14 |
platelet activation | -0.01 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
MAPKKK cascade | -0.003 | 0.03 | 0.14 | 2 | -10000 | 0 | 2 |
IL18 | -0.001 | 0.039 | -10000 | 0 | -0.22 | 3 | 3 |
negative regulation of macrophage activation | -0.009 | 0.024 | -10000 | 0 | -0.07 | 25 | 25 |
LEF | -0.009 | 0.024 | -10000 | 0 | -0.07 | 25 | 25 |
CASP1 | -0.015 | 0.036 | -10000 | 0 | -0.15 | 7 | 7 |
mol:cAMP | -0.01 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
necrosis | -0.009 | 0.024 | -10000 | 0 | -0.07 | 25 | 25 |
intracellular pH reduction | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PAGA | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Edema toxin (unfolded) | -0.025 | 0.11 | -10000 | 0 | -0.29 | 25 | 25 |
mol:Epigallocatechin-3-gallate (EGCG) | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CENTA1/KIF3B | 0.014 | 0.03 | -9999 | 0 | -0.4 | 1 | 1 |
ARNO/beta Arrestin1-2 | -0.032 | 0.083 | -9999 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
EPHA2 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
USP6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IQSEC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGFR/EGFR/EGF/EGF | -0.14 | 0.2 | -9999 | 0 | -0.36 | 80 | 80 |
ARRB2 | 0.007 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0.009 | 0.027 | -9999 | 0 | -10000 | 0 | 0 |
ARRB1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
FBXO8 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
TSHR | -0.018 | 0.1 | -9999 | 0 | -0.42 | 12 | 12 |
EGF | -0.2 | 0.26 | -9999 | 0 | -0.5 | 79 | 79 |
somatostatin receptor activity | 0 | 0 | -9999 | 0 | -0.001 | 21 | 21 |
ARAP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.049 | 0.1 | -9999 | 0 | -0.29 | 19 | 19 |
mol:PI-3-4-5-P3 | 0 | 0 | -9999 | 0 | -0.001 | 7 | 7 |
ITGA2B | -0.026 | 0.12 | -9999 | 0 | -0.43 | 16 | 16 |
ARF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ephrin A1/EPHA2/NCK1/GIT1 | 0.026 | 0.042 | -9999 | 0 | -0.35 | 2 | 2 |
ADAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KIF13B | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
HGF/MET | -0.034 | 0.14 | -9999 | 0 | -0.41 | 23 | 23 |
PXN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF6/GTP | -0.052 | 0.1 | -9999 | 0 | -0.27 | 17 | 17 |
EGFR/EGFR/EGF/EGF/ARFGEP100 | -0.11 | 0.17 | -9999 | 0 | -0.4 | 33 | 33 |
ADRB2 | -0.06 | 0.18 | -9999 | 0 | -0.52 | 26 | 26 |
receptor agonist activity | 0 | 0 | -9999 | 0 | 0 | 15 | 15 |
actin filament binding | 0 | 0 | -9999 | 0 | 0 | 22 | 22 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGB3 | -0.018 | 0.13 | -9999 | 0 | -0.57 | 10 | 10 |
GNAQ | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
EFA6/PI-4-5-P2 | 0 | 0 | -9999 | 0 | -0.001 | 13 | 13 |
ARF6/GDP | -0.008 | 0.1 | -9999 | 0 | -0.34 | 10 | 10 |
ARF6/GDP/GULP/ACAP1 | -0.091 | 0.16 | -9999 | 0 | -0.44 | 21 | 21 |
alphaIIb/beta3 Integrin/paxillin/GIT1 | -0.007 | 0.1 | -9999 | 0 | -0.38 | 8 | 8 |
ACAP1 | -0.051 | 0.18 | -9999 | 0 | -0.56 | 21 | 21 |
ACAP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LHCGR/beta Arrestin2 | 0 | 0.017 | -9999 | 0 | -0.23 | 1 | 1 |
EFNA1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
HGF | -0.058 | 0.19 | -9999 | 0 | -0.57 | 23 | 23 |
CYTH3 | 0.006 | 0.041 | -9999 | 0 | -0.38 | 2 | 2 |
CYTH2 | 0.008 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
fibronectin binding | 0 | 0 | -9999 | 0 | 0 | 13 | 13 |
endosomal lumen acidification | 0 | 0 | -9999 | 0 | 0 | 15 | 15 |
microtubule-based process | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GULP1 | -0.042 | 0.17 | -9999 | 0 | -0.53 | 19 | 19 |
GNAQ/ARNO | 0.01 | 0.036 | -9999 | 0 | -10000 | 0 | 0 |
mol:Phosphatidic acid | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIP3-E | 0 | 0 | -9999 | 0 | 0 | 6 | 6 |
MET | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA14 | -0.011 | 0.12 | -9999 | 0 | -0.6 | 7 | 7 |
GNA15 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
GIT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -0.001 | 16 | 16 |
GNA11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LHCGR | -0.001 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
AGTR1 | -0.14 | 0.25 | -9999 | 0 | -0.52 | 54 | 54 |
desensitization of G-protein coupled receptor protein signaling pathway | 0 | 0.017 | -9999 | 0 | -0.23 | 1 | 1 |
IPCEF1/ARNO | -0.084 | 0.13 | -9999 | 0 | -0.36 | 1 | 1 |
alphaIIb/beta3 Integrin | -0.031 | 0.13 | -9999 | 0 | -0.35 | 25 | 25 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PDGFRB | -0.017 | 0.13 | -10000 | 0 | -0.61 | 9 | 9 |
Jak2/Leptin Receptor | -0.046 | 0.099 | -10000 | 0 | -0.33 | 14 | 14 |
PTP1B/AKT1 | -0.016 | 0.071 | -10000 | 0 | -0.29 | 5 | 5 |
FYN | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
p210 bcr-abl/PTP1B | -0.026 | 0.079 | 0.16 | 1 | -0.29 | 8 | 9 |
EGFR | 0.004 | 0.044 | -10000 | 0 | -0.42 | 2 | 2 |
EGF/EGFR | -0.12 | 0.14 | -10000 | 0 | -0.37 | 37 | 37 |
CSF1 | -0.006 | 0.1 | -10000 | 0 | -0.56 | 6 | 6 |
AKT1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
INSR | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PTP1B/N-cadherin | -0.09 | 0.16 | -10000 | 0 | -0.37 | 42 | 42 |
Insulin Receptor/Insulin | -0.02 | 0.047 | -10000 | 0 | -0.3 | 1 | 1 |
HCK | -0.041 | 0.17 | -10000 | 0 | -0.58 | 17 | 17 |
CRK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TYK2 | -0.018 | 0.075 | -10000 | 0 | -0.31 | 5 | 5 |
EGF | -0.2 | 0.26 | -10000 | 0 | -0.5 | 79 | 79 |
YES1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CAV1 | -0.039 | 0.097 | -10000 | 0 | -0.33 | 7 | 7 |
TXN | 0.009 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
PTP1B/IRS1/GRB2 | -0.022 | 0.091 | -10000 | 0 | -0.34 | 8 | 8 |
cell migration | 0.026 | 0.079 | 0.29 | 8 | -0.16 | 1 | 9 |
STAT3 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PRLR | -0.052 | 0.19 | -10000 | 0 | -0.64 | 19 | 19 |
ITGA2B | -0.027 | 0.12 | -10000 | 0 | -0.43 | 16 | 16 |
CSF1R | -0.064 | 0.2 | -10000 | 0 | -0.57 | 25 | 25 |
Prolactin Receptor/Prolactin | -0.064 | 0.16 | -10000 | 0 | -0.42 | 30 | 30 |
FGR | -0.041 | 0.17 | -10000 | 0 | -0.55 | 18 | 18 |
PTP1B/p130 Cas | -0.018 | 0.075 | -10000 | 0 | -0.31 | 5 | 5 |
Crk/p130 Cas | -0.011 | 0.072 | -10000 | 0 | -0.3 | 5 | 5 |
DOK1 | -0.019 | 0.1 | -10000 | 0 | -0.44 | 7 | 7 |
JAK2 | -0.037 | 0.1 | -10000 | 0 | -0.33 | 13 | 13 |
Jak2/Leptin Receptor/Leptin | -0.045 | 0.092 | -10000 | 0 | -0.44 | 5 | 5 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTPN1 | -0.026 | 0.08 | 0.16 | 1 | -0.29 | 8 | 9 |
LYN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDH2 | -0.13 | 0.25 | -10000 | 0 | -0.55 | 47 | 47 |
SRC | 0.004 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
ITGB3 | -0.019 | 0.13 | -10000 | 0 | -0.57 | 10 | 10 |
CAT1/PTP1B | -0.09 | 0.2 | -10000 | 0 | -0.55 | 22 | 22 |
CAPN1 | 0.011 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
CSK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | -0.011 | 0.043 | -10000 | 0 | -10000 | 0 | 0 |
mol:H2O2 | -0.001 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
STAT3 (dimer) | -0.036 | 0.089 | -10000 | 0 | -0.51 | 3 | 3 |
negative regulation of transcription | -0.036 | 0.1 | -10000 | 0 | -0.33 | 13 | 13 |
FCGR2A | -0.019 | 0.14 | -10000 | 0 | -0.59 | 10 | 10 |
FER | 0.007 | 0.031 | -10000 | 0 | -0.41 | 1 | 1 |
alphaIIb/beta3 Integrin | -0.04 | 0.13 | -10000 | 0 | -0.35 | 25 | 25 |
BLK | -0.13 | 0.23 | -10000 | 0 | -0.49 | 52 | 52 |
Insulin Receptor/Insulin/Shc | 0.015 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
RHOA | 0.011 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
LEPR | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
BCAR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
p210 bcr-abl/Grb2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:NADPH | -0.002 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
TRPV6 | -0.094 | 0.22 | -10000 | 0 | -0.62 | 20 | 20 |
PRL | -0.024 | 0.11 | -10000 | 0 | -0.41 | 14 | 14 |
SOCS3 | 0.006 | 0.1 | -10000 | 0 | -1.4 | 1 | 1 |
SPRY2 | 0.011 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/IRS1 | 0.002 | 0.075 | -10000 | 0 | -0.4 | 6 | 6 |
CSF1/CSF1R | -0.058 | 0.17 | -10000 | 0 | -0.46 | 23 | 23 |
Ras protein signal transduction | 0.021 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
IRS1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
INS | -0.002 | 0.03 | -10000 | 0 | -0.41 | 1 | 1 |
LEP | -0.038 | 0.13 | -10000 | 0 | -0.42 | 21 | 21 |
STAT5B | -0.027 | 0.078 | -10000 | 0 | -0.25 | 10 | 10 |
STAT5A | -0.027 | 0.078 | -10000 | 0 | -0.25 | 10 | 10 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB | -0.034 | 0.13 | -10000 | 0 | -0.5 | 10 | 10 |
CSN2 | -0.012 | 0.064 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
LAT | -0.034 | 0.15 | -10000 | 0 | -0.58 | 12 | 12 |
YBX1 | 0.018 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
LCK | -0.051 | 0.16 | -10000 | 0 | -0.47 | 25 | 25 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NOX4 | -0.087 | 0.21 | -10000 | 0 | -0.51 | 36 | 36 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PDGFRA | -0.035 | 0.16 | -9999 | 0 | -0.62 | 14 | 14 |
PDGF/PDGFRA/CRKL | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
positive regulation of JUN kinase activity | 0.004 | 0.093 | -9999 | 0 | -0.34 | 13 | 13 |
CRKL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGF/PDGFRA/Caveolin-3 | -0.025 | 0.12 | -9999 | 0 | -0.44 | 15 | 15 |
AP1 | -0.073 | 0.22 | -9999 | 0 | -0.95 | 9 | 9 |
mol:IP3 | -0.015 | 0.12 | -9999 | 0 | -0.45 | 14 | 14 |
PLCG1 | -0.015 | 0.12 | -9999 | 0 | -0.46 | 14 | 14 |
PDGF/PDGFRA/alphaV Integrin | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
RAPGEF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CRK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.015 | 0.12 | -9999 | 0 | -0.45 | 14 | 14 |
CAV3 | 0 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
CAV1 | -0.004 | 0.089 | -9999 | 0 | -0.49 | 6 | 6 |
SHC/Grb2/SOS1 | 0.005 | 0.093 | -9999 | 0 | -0.34 | 13 | 13 |
PDGF/PDGFRA/Shf | -0.065 | 0.17 | -9999 | 0 | -0.39 | 39 | 39 |
FOS | -0.038 | 0.22 | -9999 | 0 | -0.94 | 9 | 9 |
JUN | -0.008 | 0.04 | -9999 | 0 | -0.52 | 1 | 1 |
oligodendrocyte development | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:DAG | -0.015 | 0.12 | -9999 | 0 | -0.45 | 14 | 14 |
PDGF/PDGFRA | -0.035 | 0.16 | -9999 | 0 | -0.62 | 14 | 14 |
actin cytoskeleton reorganization | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
SRF | 0.02 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | -0.004 | 0.1 | -9999 | 0 | -0.38 | 13 | 13 |
PDGF/PDGFRA/Crk/C3G | -0.004 | 0.1 | -9999 | 0 | -0.38 | 13 | 13 |
JAK1 | -0.016 | 0.12 | -9999 | 0 | -0.44 | 15 | 15 |
ELK1/SRF | 0.007 | 0.094 | -9999 | 0 | -0.34 | 13 | 13 |
SHB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SHF | -0.056 | 0.17 | -9999 | 0 | -0.47 | 27 | 27 |
CSNK2A1 | 0.006 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
GO:0007205 | -0.016 | 0.13 | -9999 | 0 | -0.47 | 14 | 14 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ras protein signal transduction | 0.004 | 0.093 | -9999 | 0 | -0.34 | 13 | 13 |
PDGF/PDGFRA/SHB | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
PDGF/PDGFRA/Caveolin-1 | -0.027 | 0.14 | -9999 | 0 | -0.43 | 19 | 19 |
ITGAV | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ELK1 | -0.007 | 0.11 | -9999 | 0 | -0.42 | 13 | 13 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGF/PDGFRA/Crk | -0.016 | 0.12 | -9999 | 0 | -0.44 | 14 | 14 |
JAK-STAT cascade | -0.016 | 0.12 | -9999 | 0 | -0.44 | 15 | 15 |
cell proliferation | -0.065 | 0.17 | -9999 | 0 | -0.39 | 39 | 39 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
VEGFR2 homodimer/VEGFA homodimer | 0.011 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
PDGFRB | -0.019 | 0.13 | -9999 | 0 | -0.62 | 9 | 9 |
SPHK1 | -0.069 | 0.21 | -9999 | 0 | -0.84 | 12 | 12 |
mol:S1P | -0.066 | 0.19 | -9999 | 0 | -0.75 | 12 | 12 |
S1P1/S1P/Gi | -0.078 | 0.22 | -9999 | 0 | -0.55 | 25 | 25 |
GNAO1 | -0.1 | 0.23 | -9999 | 0 | -0.54 | 39 | 39 |
PDGFB-D/PDGFRB/PLCgamma1 | -0.071 | 0.21 | -9999 | 0 | -0.61 | 18 | 18 |
PLCG1 | -0.07 | 0.21 | -9999 | 0 | -0.59 | 18 | 18 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB | -0.019 | 0.13 | -9999 | 0 | -0.62 | 9 | 9 |
GNAI2 | 0.01 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.01 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.01 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EDG1 | 0.009 | 0.043 | -9999 | 0 | -0.4 | 2 | 2 |
S1P1/S1P | -0.056 | 0.15 | -9999 | 0 | -0.56 | 13 | 13 |
negative regulation of cAMP metabolic process | -0.076 | 0.21 | -9999 | 0 | -0.53 | 25 | 25 |
MAPK3 | -0.088 | 0.25 | -9999 | 0 | -0.67 | 23 | 23 |
calcium-dependent phospholipase C activity | -0.001 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KDR | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
PLCB2 | -0.03 | 0.15 | -9999 | 0 | -0.49 | 14 | 14 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GTP | -0.047 | 0.12 | -9999 | 0 | -0.45 | 13 | 13 |
receptor internalization | -0.052 | 0.14 | -9999 | 0 | -0.51 | 13 | 13 |
PTGS2 | -0.12 | 0.33 | -9999 | 0 | -0.98 | 21 | 21 |
Rac1/GTP | -0.047 | 0.12 | -9999 | 0 | -0.45 | 13 | 13 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFA | 0.011 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
negative regulation of T cell proliferation | -0.076 | 0.21 | -9999 | 0 | -0.53 | 25 | 25 |
GO:0007205 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAZ | -0.01 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
MAPK1 | -0.088 | 0.25 | -9999 | 0 | -0.67 | 23 | 23 |
S1P1/S1P/PDGFB-D/PDGFRB | -0.038 | 0.17 | -9999 | 0 | -0.47 | 20 | 20 |
ABCC1 | 0.011 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CDKN2A | -0.039 | 0.13 | -10000 | 0 | -0.36 | 26 | 26 |
TP53 | -0.039 | 0.094 | -10000 | 0 | -0.36 | 13 | 13 |
Senescence | -0.039 | 0.094 | -10000 | 0 | -0.36 | 13 | 13 |
Apoptosis | -0.039 | 0.094 | -10000 | 0 | -0.36 | 13 | 13 |
Activated_Oncogenes | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MDM2 | 0.027 | 0.072 | 0.28 | 9 | -10000 | 0 | 9 |
MDM4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MDK | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
GPC2 | -0.022 | 0.14 | -9999 | 0 | -0.64 | 10 | 10 |
GPC2/Midkine | -0.015 | 0.12 | -9999 | 0 | -0.47 | 13 | 13 |
neuron projection morphogenesis | -0.015 | 0.12 | -9999 | 0 | -0.47 | 13 | 13 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TGFB1 | -0.044 | 0.14 | -10000 | 0 | -0.44 | 16 | 16 |
CD4-positive alpha-beta T cell lineage commitment | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cytokine production during immune response | 0.033 | 0.16 | 0.64 | 6 | -10000 | 0 | 6 |
IL27/IL27R/JAK1 | -0.055 | 0.2 | -10000 | 0 | -0.78 | 8 | 8 |
TBX21 | -0.063 | 0.25 | -10000 | 0 | -0.62 | 23 | 23 |
IL12B | -0.006 | 0.074 | -10000 | 0 | -0.42 | 6 | 6 |
IL12A | -0.035 | 0.13 | -10000 | 0 | -0.43 | 19 | 19 |
IL6ST | -0.016 | 0.13 | -10000 | 0 | -0.64 | 8 | 8 |
IL27RA/JAK1 | 0 | 0.13 | -10000 | 0 | -1.2 | 2 | 2 |
IL27 | -0.008 | 0.082 | -10000 | 0 | -0.43 | 7 | 7 |
TYK2 | 0.011 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
T-helper cell lineage commitment | -0.2 | 0.37 | -10000 | 0 | -1.2 | 17 | 17 |
T-helper 2 cell differentiation | 0.033 | 0.16 | 0.64 | 6 | -10000 | 0 | 6 |
T cell proliferation during immune response | 0.033 | 0.16 | 0.64 | 6 | -10000 | 0 | 6 |
MAPKKK cascade | -0.033 | 0.16 | -10000 | 0 | -0.64 | 6 | 6 |
STAT3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAT2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 | 0.005 | 0.054 | -10000 | 0 | -0.42 | 3 | 3 |
IL12RB1 | -0.043 | 0.17 | -10000 | 0 | -0.56 | 18 | 18 |
positive regulation of tyrosine phosphorylation of STAT protein | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL12RB2 | -0.05 | 0.23 | -10000 | 0 | -0.62 | 16 | 16 |
IL27/IL27R/JAK2/TYK2 | -0.034 | 0.16 | -10000 | 0 | -0.65 | 6 | 6 |
positive regulation of T cell mediated cytotoxicity | -0.033 | 0.16 | -10000 | 0 | -0.64 | 6 | 6 |
STAT1 (dimer) | -0.079 | 0.27 | 0.39 | 4 | -0.89 | 12 | 16 |
JAK2 | 0.005 | 0.056 | -10000 | 0 | -0.43 | 3 | 3 |
JAK1 | 0.009 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
STAT2 (dimer) | -0.026 | 0.15 | -10000 | 0 | -0.67 | 5 | 5 |
T cell proliferation | -0.12 | 0.21 | -10000 | 0 | -0.5 | 31 | 31 |
IL12/IL12R/TYK2/JAK2 | -0.048 | 0.15 | -10000 | 0 | -0.52 | 8 | 8 |
IL17A | -0.2 | 0.37 | -10000 | 0 | -1.2 | 17 | 17 |
mast cell activation | 0.033 | 0.16 | 0.64 | 6 | -10000 | 0 | 6 |
IFNG | -0.014 | 0.046 | -10000 | 0 | -0.11 | 27 | 27 |
T cell differentiation | -0.005 | 0.008 | -10000 | 0 | -0.022 | 25 | 25 |
STAT3 (dimer) | -0.026 | 0.15 | -10000 | 0 | -0.67 | 5 | 5 |
STAT5A (dimer) | -0.026 | 0.15 | -10000 | 0 | -0.67 | 5 | 5 |
STAT4 (dimer) | -0.056 | 0.2 | -10000 | 0 | -0.63 | 14 | 14 |
STAT4 | -0.046 | 0.18 | -10000 | 0 | -0.58 | 19 | 19 |
T cell activation | -0.006 | 0.014 | 0.12 | 2 | -10000 | 0 | 2 |
IL27R/JAK2/TYK2 | -0.021 | 0.15 | -10000 | 0 | -1.2 | 2 | 2 |
GATA3 | -0.044 | 0.27 | -10000 | 0 | -1.3 | 8 | 8 |
IL18 | 0.008 | 0.022 | -10000 | 0 | -0.29 | 1 | 1 |
positive regulation of mast cell cytokine production | -0.026 | 0.15 | -10000 | 0 | -0.65 | 5 | 5 |
IL27/EBI3 | -0.038 | 0.15 | -10000 | 0 | -0.43 | 23 | 23 |
IL27RA | -0.01 | 0.14 | -10000 | 0 | -1.3 | 2 | 2 |
IL6 | -0.18 | 0.28 | -10000 | 0 | -0.57 | 60 | 60 |
STAT5A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
monocyte differentiation | -0.001 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
IL2 | 0.007 | 0.053 | 0.49 | 2 | -10000 | 0 | 2 |
IL1B | -0.047 | 0.14 | -10000 | 0 | -0.37 | 29 | 29 |
EBI3 | -0.046 | 0.18 | -10000 | 0 | -0.57 | 19 | 19 |
TNF | -0.011 | 0.095 | -10000 | 0 | -0.44 | 9 | 9 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NCK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRKL | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
GRB2/SOS1/SHC | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IRS1/Crk | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
IGF-1R heterotetramer/IGF1/PTP1B | -0.072 | 0.13 | -10000 | 0 | -0.38 | 24 | 24 |
AKT1 | -0.022 | 0.12 | -10000 | 0 | -0.52 | 2 | 2 |
BAD | -0.014 | 0.11 | -10000 | 0 | -0.48 | 2 | 2 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRK | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
IGF-1R heterotetramer/IGF1/IRS1/Shp2 | -0.048 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
RAF1 | -0.008 | 0.1 | -10000 | 0 | -0.46 | 2 | 2 |
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos | -0.037 | 0.13 | -10000 | 0 | -0.32 | 24 | 24 |
YWHAZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1/IRS1 | -0.059 | 0.14 | -10000 | 0 | -0.36 | 28 | 28 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RPS6KB1 | -0.022 | 0.12 | -10000 | 0 | -0.52 | 2 | 2 |
GNB2L1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of MAPKKK cascade | -0.009 | 0.092 | -10000 | 0 | -0.39 | 2 | 2 |
PXN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell adhesion | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB2/SOS1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HRAS/GTP | -0.052 | 0.1 | -10000 | 0 | -0.53 | 2 | 2 |
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc | -0.028 | 0.12 | -10000 | 0 | -0.36 | 2 | 2 |
IGF-1R heterotetramer | -0.005 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1/IRS/Nck | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
Crk/p130 Cas/Paxillin | -0.03 | 0.12 | -10000 | 0 | -0.57 | 2 | 2 |
IGF1R | -0.005 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
IGF1 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 47 | 47 |
IRS2/Crk | -0.042 | 0.13 | -10000 | 0 | -0.33 | 25 | 25 |
PI3K | -0.037 | 0.13 | -10000 | 0 | -0.32 | 24 | 24 |
apoptosis | 0.006 | 0.098 | 0.41 | 2 | -10000 | 0 | 2 |
HRAS/GDP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCD | -0.037 | 0.15 | -10000 | 0 | -0.41 | 24 | 24 |
RAF1/14-3-3 E | 0 | 0.094 | -10000 | 0 | -0.39 | 2 | 2 |
BAD/14-3-3 | -0.007 | 0.1 | -10000 | 0 | -0.44 | 2 | 2 |
PRKCZ | -0.022 | 0.12 | -10000 | 0 | -0.52 | 2 | 2 |
Crk/p130 Cas/Paxillin/FAK1 | -0.041 | 0.081 | -10000 | 0 | -0.44 | 2 | 2 |
PTPN1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 | -0.046 | 0.16 | -10000 | 0 | -0.44 | 24 | 24 |
BCAR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1/SHC/GRB10 | -0.041 | 0.13 | -10000 | 0 | -0.33 | 25 | 25 |
mol:GDP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IRS1/NCK2 | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
GRB10 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
PTPN11 | -0.047 | 0.13 | -10000 | 0 | -0.33 | 28 | 28 |
IRS1 | -0.059 | 0.14 | -10000 | 0 | -0.36 | 28 | 28 |
IRS2 | -0.052 | 0.14 | -10000 | 0 | -0.34 | 29 | 29 |
IGF-1R heterotetramer/IGF1 | -0.084 | 0.18 | -10000 | 0 | -0.39 | 47 | 47 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PDPK1 | -0.03 | 0.12 | -10000 | 0 | -0.56 | 2 | 2 |
YWHAE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKD1 | -0.072 | 0.2 | -10000 | 0 | -0.46 | 36 | 36 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GNB1/GNG2 | -0.027 | 0.13 | -10000 | 0 | -0.34 | 23 | 23 |
ER alpha/Gai/GDP/Gbeta gamma | -0.066 | 0.22 | -10000 | 0 | -0.65 | 18 | 18 |
AKT1 | -0.044 | 0.23 | -10000 | 0 | -0.85 | 14 | 14 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
E2/ER alpha (dimer)/PELP1/Src/PI3K | -0.049 | 0.24 | -10000 | 0 | -0.87 | 14 | 14 |
mol:Ca2+ | -0.045 | 0.15 | -10000 | 0 | -0.47 | 11 | 11 |
IGF1R | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
E2/ER alpha (dimer)/Striatin | -0.031 | 0.12 | -10000 | 0 | -0.32 | 27 | 27 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | 0.041 | 0.22 | 0.8 | 14 | -10000 | 0 | 14 |
RhoA/GTP | -0.032 | 0.082 | -10000 | 0 | -10000 | 0 | 0 |
E2/ER alpha (dimer)/PELP1/Src/p130 Cas | -0.079 | 0.17 | -10000 | 0 | -0.56 | 18 | 18 |
regulation of stress fiber formation | -0.012 | 0.083 | 0.28 | 1 | -10000 | 0 | 1 |
E2/ERA-ERB (dimer) | -0.041 | 0.14 | -10000 | 0 | -0.34 | 31 | 31 |
KRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
G13/GTP | -0.028 | 0.11 | -10000 | 0 | -0.29 | 27 | 27 |
pseudopodium formation | 0.012 | 0.083 | -10000 | 0 | -0.28 | 1 | 1 |
E2/ER alpha (dimer)/PELP1 | -0.031 | 0.12 | -10000 | 0 | -0.32 | 27 | 27 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNG2 | 0.001 | 0.078 | -10000 | 0 | -0.52 | 4 | 4 |
GNAO1 | -0.099 | 0.22 | -10000 | 0 | -0.53 | 39 | 39 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:NO | -0.047 | 0.19 | -10000 | 0 | -0.59 | 17 | 17 |
E2/ER beta (dimer) | -0.003 | 0.072 | -10000 | 0 | -0.44 | 5 | 5 |
mol:GDP | -0.049 | 0.12 | -10000 | 0 | -0.41 | 19 | 19 |
mol:NADP | -0.047 | 0.19 | -10000 | 0 | -0.59 | 17 | 17 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:IP3 | -0.047 | 0.16 | -10000 | 0 | -0.49 | 11 | 11 |
IGF-1R heterotetramer | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLCB1 | -0.048 | 0.15 | -10000 | 0 | -0.51 | 10 | 10 |
PLCB2 | -0.022 | 0.13 | -10000 | 0 | -0.49 | 9 | 9 |
IGF1 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 47 | 47 |
mol:L-citrulline | -0.047 | 0.19 | -10000 | 0 | -0.59 | 17 | 17 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Gai/GDP | -0.079 | 0.26 | -10000 | 0 | -0.78 | 21 | 21 |
JNK cascade | -0.003 | 0.072 | -10000 | 0 | -0.44 | 5 | 5 |
BCAR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ESR2 | -0.004 | 0.097 | -10000 | 0 | -0.59 | 5 | 5 |
GNAQ | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
ESR1 | -0.064 | 0.19 | -10000 | 0 | -0.53 | 27 | 27 |
Gq family/GDP/Gbeta gamma | -0.002 | 0.12 | -10000 | 0 | -0.51 | 8 | 8 |
E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 | -0.004 | 0.09 | -10000 | 0 | -10000 | 0 | 0 |
E2/ER alpha (dimer)/PELP1/Src/p52 SHC | -0.079 | 0.17 | -10000 | 0 | -0.56 | 18 | 18 |
GNAZ | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
E2/ER alpha (dimer) | -0.047 | 0.14 | -10000 | 0 | -0.39 | 27 | 27 |
STRN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAL | -0.019 | 0.12 | -10000 | 0 | -0.49 | 12 | 12 |
PELP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK11 | 0.003 | 0.071 | -10000 | 0 | -0.35 | 7 | 7 |
GNAI2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
HBEGF | -0.083 | 0.23 | -10000 | 0 | -0.65 | 20 | 20 |
cAMP biosynthetic process | -0.058 | 0.12 | -10000 | 0 | -0.34 | 25 | 25 |
SRC | -0.056 | 0.21 | -10000 | 0 | -0.6 | 18 | 18 |
PI3K | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
G13/GDP/Gbeta gamma | -0.047 | 0.11 | -10000 | 0 | -0.37 | 16 | 16 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1 | -0.11 | 0.18 | -10000 | 0 | -0.5 | 26 | 26 |
Gs family/GTP | -0.059 | 0.12 | -10000 | 0 | -0.35 | 25 | 25 |
EntrezGene:2778 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
vasodilation | -0.044 | 0.18 | -10000 | 0 | -0.56 | 17 | 17 |
mol:DAG | -0.047 | 0.16 | -10000 | 0 | -0.49 | 11 | 11 |
Gs family/GDP/Gbeta gamma | -0.055 | 0.12 | -10000 | 0 | -0.38 | 15 | 15 |
MSN | 0.011 | 0.088 | -10000 | 0 | -0.3 | 1 | 1 |
Gq family/GTP | -0.022 | 0.13 | -10000 | 0 | -0.52 | 8 | 8 |
mol:PI-3-4-5-P3 | -0.046 | 0.22 | -10000 | 0 | -0.83 | 14 | 14 |
NRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:E2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell adhesion | 0.044 | 0.18 | 0.56 | 17 | -10000 | 0 | 17 |
GRB2/SOS1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoA/GDP | -0.045 | 0.12 | -10000 | 0 | -0.39 | 18 | 18 |
NOS3 | -0.051 | 0.2 | -10000 | 0 | -0.63 | 17 | 17 |
GNA11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPKKK cascade | -0.029 | 0.19 | -10000 | 0 | -0.67 | 14 | 14 |
E2/ER alpha (dimer)/PELP1/Src | -0.085 | 0.18 | -10000 | 0 | -0.6 | 18 | 18 |
ruffle organization | 0.012 | 0.083 | -10000 | 0 | -0.28 | 1 | 1 |
ROCK2 | 0.007 | 0.089 | -10000 | 0 | -10000 | 0 | 0 |
GNA14 | -0.011 | 0.12 | -10000 | 0 | -0.6 | 7 | 7 |
GNA15 | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
GNA13 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MMP9 | -0.094 | 0.24 | -10000 | 0 | -0.65 | 21 | 21 |
MMP2 | -0.073 | 0.24 | -10000 | 0 | -0.73 | 16 | 16 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ERK1-2/ELK1 | -0.038 | 0.21 | -9999 | 0 | -0.74 | 12 | 12 |
MAP3K8 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
FOS | -0.041 | 0.2 | -9999 | 0 | -0.7 | 13 | 13 |
PRKCA | 0.005 | 0.066 | -9999 | 0 | -0.63 | 2 | 2 |
PTPN7 | -0.069 | 0.19 | -9999 | 0 | -0.49 | 31 | 31 |
HRAS | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
PRKCB | -0.067 | 0.2 | -9999 | 0 | -0.55 | 27 | 27 |
NRAS | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
RAS family/GTP | 0.023 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | -0.037 | 0.18 | -9999 | 0 | -0.71 | 11 | 11 |
MAP2K1 | -0.019 | 0.14 | -9999 | 0 | -0.44 | 19 | 19 |
ELK1 | 0.012 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
BRAF | -0.026 | 0.14 | -9999 | 0 | -0.44 | 19 | 19 |
mol:GTP | 0 | 0.001 | -9999 | 0 | -0.004 | 13 | 13 |
MAPK1 | -0.037 | 0.18 | -9999 | 0 | -0.71 | 11 | 11 |
RAF1 | -0.026 | 0.14 | -9999 | 0 | -0.44 | 19 | 19 |
KRAS | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Cone Metarhodopsin II/Cone Transducin | -0.017 | 0.11 | -9999 | 0 | -0.35 | 17 | 17 |
RGS9BP | 0.003 | 0.063 | -9999 | 0 | -0.49 | 3 | 3 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRK1 | 0 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
mol:Na + | -0.06 | 0.13 | -9999 | 0 | -0.29 | 45 | 45 |
mol:ADP | 0.007 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
GNAT2 | 0.009 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RGS9-1/Gbeta5/R9AP | -0.023 | 0.13 | -9999 | 0 | -0.44 | 13 | 13 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDE6H/GNAT2/GTP | 0.007 | 0.018 | -9999 | 0 | -0.24 | 1 | 1 |
GRK7 | 0.008 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
CNGB3 | -0.038 | 0.12 | -9999 | 0 | -0.42 | 19 | 19 |
Cone Metarhodopsin II/X-Arrestin | -0.002 | 0.03 | -9999 | 0 | -0.29 | 2 | 2 |
mol:Ca2+ | -0.059 | 0.13 | -9999 | 0 | -0.41 | 12 | 12 |
Cone PDE6 | -0.017 | 0.11 | -9999 | 0 | -0.38 | 13 | 13 |
Cone Metarhodopsin II | 0.005 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
Na + (4 Units) | -0.059 | 0.13 | -9999 | 0 | -0.41 | 12 | 12 |
GNAT2/GDP | -0.015 | 0.11 | -9999 | 0 | -0.38 | 13 | 13 |
GNB5 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
mol:GMP (4 units) | 0.008 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
Cone Transducin | -0.017 | 0.12 | -9999 | 0 | -0.37 | 17 | 17 |
SLC24A2 | -0.01 | 0.085 | -9999 | 0 | -0.42 | 8 | 8 |
GNB3/GNGT2 | -0.031 | 0.15 | -9999 | 0 | -0.45 | 20 | 20 |
GNB3 | -0.019 | 0.14 | -9999 | 0 | -0.59 | 10 | 10 |
GNAT2/GTP | 0.007 | 0.022 | -9999 | 0 | -0.29 | 1 | 1 |
CNGA3 | -0.065 | 0.18 | -9999 | 0 | -0.48 | 29 | 29 |
ARR3 | -0.002 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
absorption of light | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cGMP/Cone CNG Channel | -0.061 | 0.13 | -9999 | 0 | -0.29 | 45 | 45 |
mol:Pi | -0.023 | 0.13 | -9999 | 0 | -0.44 | 13 | 13 |
Cone CNG Channel | -0.054 | 0.1 | -9999 | 0 | -0.35 | 11 | 11 |
mol:all-trans-retinal | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:K + | -0.01 | 0.085 | -9999 | 0 | -0.42 | 8 | 8 |
RGS9 | -0.046 | 0.17 | -9999 | 0 | -0.52 | 21 | 21 |
PDE6C | 0.003 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
GNGT2 | -0.023 | 0.14 | -9999 | 0 | -0.6 | 11 | 11 |
mol:cGMP (4 units) | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDE6H | 0.001 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ITGB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGB7 | -0.023 | 0.14 | -9999 | 0 | -0.54 | 12 | 12 |
ITGA4 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
alpha4/beta7 Integrin | -0.027 | 0.15 | -9999 | 0 | -0.48 | 17 | 17 |
alpha4/beta1 Integrin | -0.003 | 0.095 | -9999 | 0 | -0.43 | 9 | 9 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Delta 1/NOTCH/NOTCH(cleaved) | -0.009 | 0.05 | -10000 | 0 | -10000 | 0 | 0 |
HDAC1 | 0.009 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
AES | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
FBXW11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DTX1 | -0.024 | 0.14 | -10000 | 0 | -0.56 | 12 | 12 |
LRP6/FZD1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TLE1 | 0.004 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
AP1 | -0.071 | 0.14 | -10000 | 0 | -0.32 | 39 | 39 |
NCSTN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ADAM10 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 | 0.041 | 0.047 | -10000 | 0 | -10000 | 0 | 0 |
NICD/RBPSUH | 0.03 | 0 | -10000 | 0 | -10000 | 0 | 0 |
WIF1 | -0.2 | 0.26 | -10000 | 0 | -0.51 | 76 | 76 |
NOTCH1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PSENEN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KREMEN2 | -0.034 | 0.14 | -10000 | 0 | -0.45 | 19 | 19 |
DKK1 | -0.19 | 0.26 | -10000 | 0 | -0.51 | 74 | 74 |
beta catenin/beta TrCP1 | 0.059 | 0.07 | -10000 | 0 | -10000 | 0 | 0 |
APH1B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
APH1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AXIN1 | -0.012 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
CtBP/CBP/TCF1/TLE1/AES | 0.016 | 0.041 | -10000 | 0 | -0.28 | 3 | 3 |
PSEN1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.026 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
JUN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
MAP3K7 | 0.01 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.056 | 0.076 | 0.21 | 20 | -10000 | 0 | 20 |
MAPK3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DKK2/LRP6/Kremen 2 | -0.087 | 0.17 | -10000 | 0 | -0.42 | 29 | 29 |
HNF1A | 0.008 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
CTBP1 | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
MYC | 0.002 | 0.18 | -10000 | 0 | -1.4 | 3 | 3 |
NKD1 | -0.16 | 0.26 | -10000 | 0 | -0.53 | 62 | 62 |
FZD1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NOTCH1 precursor/Deltex homolog 1 | 0.012 | 0.075 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | -0.071 | 0.14 | -10000 | 0 | -0.32 | 39 | 39 |
Delta 1/NOTCHprecursor | 0.02 | 0.056 | -10000 | 0 | -10000 | 0 | 0 |
DLL1 | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
PPARD | 0.023 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
Gamma Secretase | 0.036 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
APC | -0.014 | 0.04 | -10000 | 0 | -0.44 | 1 | 1 |
DVL1 | -0.006 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
CSNK2A1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K7IP1 | -0.002 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
DKK1/LRP6/Kremen 2 | -0.13 | 0.19 | -10000 | 0 | -0.43 | 40 | 40 |
LRP6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CSNK1A1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
NLK | 0.012 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
CCND1 | 0.023 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
WNT1 | -0.005 | 0.074 | -10000 | 0 | -0.42 | 6 | 6 |
Axin1/APC/beta catenin | 0.044 | 0.043 | -10000 | 0 | -10000 | 0 | 0 |
DKK2 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 48 | 48 |
NOTCH1 precursor/DVL1 | -0.002 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
GSK3B | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
FRAT1 | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
NOTCH/Deltex homolog 1 | -0.017 | 0.068 | -10000 | 0 | -10000 | 0 | 0 |
PPP2R5D | 0.075 | 0.12 | 0.25 | 62 | -10000 | 0 | 62 |
MAPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
WNT1/LRP6/FZD1 | -0.098 | 0.16 | -10000 | 0 | -0.38 | 34 | 34 |
RBPJ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.015 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
UBC13/UEV1A | 0.012 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
PRKCZ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K7IP2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ERC1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 | -0.032 | 0.07 | -9999 | 0 | -0.3 | 6 | 6 |
IRAK/TOLLIP | 0.025 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
IKBKB | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
IKBKG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1 alpha/IL1R2 | -0.12 | 0.22 | -9999 | 0 | -0.42 | 63 | 63 |
IL1A | -0.11 | 0.23 | -9999 | 0 | -0.52 | 43 | 43 |
IL1B | -0.057 | 0.17 | -9999 | 0 | -0.4 | 35 | 35 |
IRAK/TRAF6/p62/Atypical PKCs | -0.002 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
IL1R2 | -0.068 | 0.2 | -9999 | 0 | -0.53 | 28 | 28 |
IL1R1 | -0.02 | 0.13 | -9999 | 0 | -0.51 | 12 | 12 |
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP | 0.004 | 0.082 | -9999 | 0 | -0.36 | 2 | 2 |
TOLLIP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TICAM2 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
MAP3K3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TAK1/TAB1/TAB2 | 0.008 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex/ELKS | 0.055 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
JUN | 0.031 | 0.048 | -9999 | 0 | -0.29 | 1 | 1 |
MAP3K7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1 beta fragment/IL1R1/IL1RAP/PI3K | -0.03 | 0.15 | -9999 | 0 | -0.53 | 8 | 8 |
IL1 alpha/IL1R1/IL1RAP/MYD88 | -0.055 | 0.16 | -9999 | 0 | -0.41 | 24 | 24 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 | -0.046 | 0.15 | -9999 | 0 | -0.38 | 24 | 24 |
IL1 beta fragment/IL1R1/IL1RAP | -0.048 | 0.16 | -9999 | 0 | -0.44 | 22 | 22 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.027 | 0.044 | -9999 | 0 | -0.29 | 3 | 3 |
IRAK1 | 0.019 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
IL1RN/IL1R1 | -0.063 | 0.18 | -9999 | 0 | -0.41 | 36 | 36 |
IRAK4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCI | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
TRAF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP | -0.011 | 0.1 | -9999 | 0 | -0.39 | 6 | 6 |
CHUK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1 beta fragment/IL1R1/IL1RAP/MYD88s | -0.048 | 0.16 | -9999 | 0 | -0.44 | 22 | 22 |
IL1 beta/IL1R2 | -0.091 | 0.19 | -9999 | 0 | -0.34 | 60 | 60 |
IRAK/TRAF6/TAK1/TAB1/TAB2 | -0.001 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA | -0.055 | 0.12 | -9999 | 0 | -0.54 | 6 | 6 |
IRAK3 | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
IL1 beta fragment/IL1R1/IL1RAP/TICAM2/IRAK4 | -0.034 | 0.15 | -9999 | 0 | -0.38 | 24 | 24 |
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP | -0.027 | 0.12 | -9999 | 0 | -0.31 | 23 | 23 |
IL1 alpha/IL1R1/IL1RAP | -0.069 | 0.17 | -9999 | 0 | -0.45 | 24 | 24 |
RELA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K7IP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SQSTM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MYD88 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRAK/TRAF6/MEKK3 | 0.031 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
IL1RAP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE2N | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRAK/TRAF6 | -0.053 | 0.11 | -9999 | 0 | -0.49 | 6 | 6 |
CASP1 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
IL1RN/IL1R2 | -0.097 | 0.21 | -9999 | 0 | -0.43 | 49 | 49 |
IL1 beta fragment/IL1R1/IL1RAP/MYD88 | -0.038 | 0.16 | -9999 | 0 | -0.41 | 22 | 22 |
TMEM189-UBE2V1 | 0.004 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP | -0.013 | 0.11 | -9999 | 0 | -0.44 | 6 | 6 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IL1RN | -0.068 | 0.2 | -9999 | 0 | -0.55 | 27 | 27 |
TRAF6/TAK1/TAB1/TAB2 | -0.001 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K6 | 0.022 | 0.047 | -9999 | 0 | -0.31 | 3 | 3 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
SPTAN1 | 0.014 | 0.06 | 0.26 | 6 | -0.33 | 1 | 7 |
RFC1 | 0.014 | 0.06 | 0.29 | 4 | -0.33 | 1 | 5 |
PRKDC | 0.012 | 0.067 | 0.29 | 4 | -0.36 | 2 | 6 |
RIPK1 | 0.014 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
CASP7 | -0.007 | 0.054 | 0.25 | 2 | -10000 | 0 | 2 |
FASLG/FAS/FADD/FAF1 | 0.01 | 0.13 | 0.23 | 27 | -0.3 | 12 | 39 |
MAP2K4 | -0.036 | 0.14 | -10000 | 0 | -0.41 | 7 | 7 |
mol:ceramide | -0.036 | 0.13 | -10000 | 0 | -0.37 | 18 | 18 |
GSN | 0.008 | 0.069 | 0.29 | 4 | -0.32 | 3 | 7 |
FASLG/FAS/FADD/FAF1/Caspase 8 | -0.002 | 0.13 | 0.21 | 20 | -0.35 | 15 | 35 |
FAS | 0.006 | 0.048 | -10000 | 0 | -0.65 | 1 | 1 |
BID | 0.015 | 0.057 | 0.3 | 6 | -10000 | 0 | 6 |
MAP3K1 | -0.006 | 0.086 | 0.25 | 2 | -0.26 | 3 | 5 |
MAP3K7 | 0.01 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
RB1 | 0.012 | 0.067 | 0.26 | 6 | -0.36 | 2 | 8 |
CFLAR | 0.014 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
HGF/MET | -0.09 | 0.21 | -10000 | 0 | -0.47 | 41 | 41 |
ARHGDIB | 0.012 | 0.067 | 0.29 | 4 | -0.36 | 2 | 6 |
FADD | 0.009 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
actin filament polymerization | -0.008 | 0.069 | 0.31 | 3 | -0.29 | 4 | 7 |
NFKB1 | -0.05 | 0.077 | -10000 | 0 | -0.28 | 4 | 4 |
MAPK8 | -0.059 | 0.18 | -10000 | 0 | -0.44 | 29 | 29 |
DFFA | 0.014 | 0.06 | 0.29 | 4 | -0.33 | 1 | 5 |
DNA fragmentation during apoptosis | 0.014 | 0.06 | 0.26 | 6 | -0.32 | 1 | 7 |
FAS/FADD/MET | 0.016 | 0.033 | -10000 | 0 | -0.42 | 1 | 1 |
CFLAR/RIP1 | 0.012 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
FAIM3 | -0.027 | 0.14 | -10000 | 0 | -0.5 | 15 | 15 |
FAF1 | 0.009 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
PARP1 | 0.014 | 0.06 | 0.29 | 4 | -0.33 | 1 | 5 |
DFFB | 0.014 | 0.06 | 0.26 | 6 | -0.33 | 1 | 7 |
CHUK | -0.043 | 0.068 | -10000 | 0 | -10000 | 0 | 0 |
FASLG | -0.071 | 0.2 | -10000 | 0 | -0.55 | 28 | 28 |
FAS/FADD | 0.01 | 0.038 | -10000 | 0 | -0.49 | 1 | 1 |
HGF | -0.058 | 0.19 | -10000 | 0 | -0.57 | 23 | 23 |
LMNA | 0.013 | 0.055 | 0.28 | 3 | -0.3 | 1 | 4 |
CASP6 | 0.014 | 0.06 | 0.26 | 6 | -0.33 | 1 | 7 |
CASP10 | 0.009 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
CASP3 | 0.017 | 0.073 | 0.28 | 9 | -0.37 | 1 | 10 |
PTPN13 | -0.1 | 0.24 | -10000 | 0 | -0.62 | 34 | 34 |
CASP8 | 0.022 | 0.08 | 0.4 | 6 | -10000 | 0 | 6 |
IL6 | -0.21 | 0.46 | -10000 | 0 | -1.2 | 29 | 29 |
MET | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ICAD/CAD | 0.013 | 0.056 | 0.28 | 3 | -0.3 | 1 | 4 |
FASLG/FAS/FADD/FAF1/Caspase 10 | -0.037 | 0.13 | -10000 | 0 | -0.38 | 18 | 18 |
activation of caspase activity by cytochrome c | 0.015 | 0.057 | 0.3 | 6 | -10000 | 0 | 6 |
PAK2 | 0.014 | 0.06 | 0.26 | 6 | -0.33 | 1 | 7 |
BCL2 | -0.004 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
VEGFR2 homodimer/VEGFA homodimer | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
alphaV beta3 Integrin | -0.024 | 0.14 | -9999 | 0 | -0.42 | 17 | 17 |
PTK2 | -0.039 | 0.16 | -9999 | 0 | -0.58 | 9 | 9 |
IGF1R | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI4KB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MFGE8 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDKN1B | -0.039 | 0.14 | -9999 | 0 | -0.54 | 10 | 10 |
VEGFA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ILK | -0.039 | 0.14 | -9999 | 0 | -0.54 | 10 | 10 |
ROCK1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
AKT1 | -0.028 | 0.13 | -9999 | 0 | -0.53 | 9 | 9 |
PTK2B | 0.015 | 0.093 | -9999 | 0 | -0.42 | 7 | 7 |
alphaV/beta3 Integrin/JAM-A | -0.046 | 0.16 | -9999 | 0 | -0.38 | 27 | 27 |
CBL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV beta3 Integrin/ANGPTL3 | 0.001 | 0.084 | -9999 | 0 | -0.4 | 7 | 7 |
IGF-1R heterotetramer/IGF1/IRS1/Shp2 | -0.056 | 0.16 | -9999 | 0 | -0.38 | 28 | 28 |
VEGF/Rho/ROCK/alphaV/beta3 Integrin | 0 | 0.088 | -9999 | 0 | -0.46 | 2 | 2 |
alphaV/beta3 Integrin/Syndecan-1 | 0.005 | 0.084 | -9999 | 0 | -0.39 | 7 | 7 |
PI4KA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer/IGF1/IRS1 | -0.15 | 0.22 | -9999 | 0 | -0.59 | 30 | 30 |
PI4 Kinase | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/Osteopontin | -0.1 | 0.19 | -9999 | 0 | -0.44 | 38 | 38 |
RPS6KB1 | -0.11 | 0.23 | -9999 | 0 | -0.54 | 30 | 30 |
TLN1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | -0.082 | 0.23 | -9999 | 0 | -0.73 | 17 | 17 |
GPR124 | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
MAPK1 | -0.082 | 0.23 | -9999 | 0 | -0.73 | 17 | 17 |
PXN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/Tumstatin | -0.081 | 0.18 | -9999 | 0 | -0.42 | 31 | 31 |
cell adhesion | -0.006 | 0.082 | -9999 | 0 | -0.36 | 9 | 9 |
ANGPTL3 | 0.005 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/Src | 0.02 | 0.042 | -9999 | 0 | -0.39 | 2 | 2 |
IGF-1R heterotetramer | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TGFBR2 | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
ITGB3 | -0.018 | 0.13 | -9999 | 0 | -0.57 | 10 | 10 |
IGF1 | -0.12 | 0.24 | -9999 | 0 | -0.53 | 47 | 47 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of cell-matrix adhesion | -0.004 | 0.12 | -9999 | 0 | -0.47 | 10 | 10 |
apoptosis | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CD47 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/CD47 | 0.005 | 0.084 | -9999 | 0 | -0.39 | 7 | 7 |
VCL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/Del1 | -0.046 | 0.18 | -9999 | 0 | -0.5 | 24 | 24 |
CSF1 | -0.006 | 0.1 | -9999 | 0 | -0.56 | 6 | 6 |
PIK3C2A | -0.039 | 0.14 | -9999 | 0 | -0.54 | 10 | 10 |
PI4 Kinase/Pyk2 | -0.062 | 0.13 | -9999 | 0 | -0.55 | 6 | 6 |
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin | 0.01 | 0.099 | -9999 | 0 | -0.45 | 7 | 7 |
FAK1/Vinculin | -0.024 | 0.13 | -9999 | 0 | -0.44 | 9 | 9 |
alphaV beta3/Integrin/ppsTEM5 | -0.004 | 0.12 | -9999 | 0 | -0.47 | 10 | 10 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VTN | -0.064 | 0.18 | -9999 | 0 | -0.48 | 29 | 29 |
BCAR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FGF2 | -0.036 | 0.16 | -9999 | 0 | -0.53 | 17 | 17 |
F11R | -0.015 | 0.12 | -9999 | 0 | -0.38 | 17 | 17 |
alphaV/beta3 Integrin/Lactadherin | 0.001 | 0.093 | -9999 | 0 | -0.39 | 9 | 9 |
alphaV/beta3 Integrin/TGFBR2 | 0.002 | 0.097 | -9999 | 0 | -0.45 | 7 | 7 |
alphaV/beta3 Integrin/c-FMS/Cbl/Cas | 0.02 | 0.059 | -9999 | 0 | -0.35 | 4 | 4 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/Talin | 0.006 | 0.077 | -9999 | 0 | -0.36 | 7 | 7 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FN1 | -0.1 | 0.23 | -9999 | 0 | -0.54 | 40 | 40 |
alphaV/beta3 Integrin/Pyk2 | 0.016 | 0.094 | -9999 | 0 | -0.42 | 7 | 7 |
SDC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VAV3 | -0.042 | 0.15 | -9999 | 0 | -0.33 | 38 | 38 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRS1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
FAK1/Paxillin | -0.024 | 0.13 | -9999 | 0 | -0.44 | 9 | 9 |
cell migration | -0.014 | 0.12 | -9999 | 0 | -0.39 | 9 | 9 |
ITGAV | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | -0.064 | 0.13 | -9999 | 0 | -0.46 | 8 | 8 |
SPP1 | -0.16 | 0.26 | -9999 | 0 | -0.54 | 60 | 60 |
KDR | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alphaV/beta3 Integrin/Caspase 8 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
COL4A3 | -0.13 | 0.24 | -9999 | 0 | -0.52 | 49 | 49 |
angiogenesis | -0.08 | 0.23 | -9999 | 0 | -0.72 | 17 | 17 |
Rac1/GTP | -0.032 | 0.14 | -9999 | 0 | -0.48 | 1 | 1 |
EDIL3 | -0.071 | 0.22 | -9999 | 0 | -0.63 | 25 | 25 |
cell proliferation | 0.002 | 0.097 | -9999 | 0 | -0.44 | 7 | 7 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PTK2 | 0.01 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNB1/GNG2 | -0.043 | 0.14 | -10000 | 0 | -0.41 | 17 | 17 |
regulation of S phase of mitotic cell cycle | -0.014 | 0.087 | -10000 | 0 | -0.27 | 15 | 15 |
GNAO1 | -0.099 | 0.22 | -10000 | 0 | -0.53 | 39 | 39 |
HRAS | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
SHBG/T-DHT | -0.002 | 0.047 | -10000 | 0 | -0.24 | 7 | 7 |
PELP1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
AKT1 | 0.01 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | -0.013 | 0.1 | -10000 | 0 | -0.34 | 1 | 1 |
T-DHT/AR | -0.069 | 0.16 | -10000 | 0 | -0.36 | 40 | 40 |
G-protein coupled receptor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0.002 | -10000 | 0 | -0.006 | 12 | 12 |
GNAI2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
mol:GDP | -0.058 | 0.13 | -10000 | 0 | -0.48 | 15 | 15 |
cell proliferation | -0.013 | 0.13 | -10000 | 0 | -0.39 | 9 | 9 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.02 | 0.18 | -10000 | 0 | -0.74 | 10 | 10 |
mol:Ca2+ | -0.019 | 0.03 | -10000 | 0 | -0.075 | 29 | 29 |
MAPK3 | -0.013 | 0.12 | -10000 | 0 | -0.4 | 3 | 3 |
MAPK1 | 0 | 0.065 | -10000 | 0 | -0.25 | 1 | 1 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:IP3 | 0 | 0.001 | -10000 | 0 | -0.004 | 13 | 13 |
cAMP biosynthetic process | 0.008 | 0.052 | -10000 | 0 | -0.22 | 7 | 7 |
GNG2 | 0.001 | 0.078 | -10000 | 0 | -0.52 | 4 | 4 |
potassium channel inhibitor activity | 0 | 0.001 | -10000 | 0 | -0.004 | 13 | 13 |
HRAS/GTP | -0.049 | 0.099 | -10000 | 0 | -0.32 | 15 | 15 |
actin cytoskeleton reorganization | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
voltage-gated calcium channel activity | 0 | 0.001 | -10000 | 0 | -0.004 | 13 | 13 |
PI3K | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | 0.006 | 0.11 | 0.4 | 9 | -10000 | 0 | 9 |
T-DHT/AR/PELP1 | -0.05 | 0.13 | -10000 | 0 | -0.3 | 40 | 40 |
HRAS/GDP | -0.053 | 0.12 | -10000 | 0 | -0.45 | 15 | 15 |
CREB1 | -0.008 | 0.12 | -10000 | 0 | -0.43 | 9 | 9 |
RAC1-CDC42/GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AR | -0.095 | 0.21 | -10000 | 0 | -0.5 | 40 | 40 |
GNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAF1 | -0.02 | 0.11 | -10000 | 0 | -0.34 | 1 | 1 |
RAC1-CDC42/GDP | -0.05 | 0.12 | -10000 | 0 | -0.43 | 15 | 15 |
T-DHT/AR/PELP1/Src | -0.038 | 0.12 | -10000 | 0 | -0.36 | 15 | 15 |
MAP2K2 | -0.013 | 0.1 | -10000 | 0 | -0.34 | 1 | 1 |
T-DHT/AR/PELP1/Src/PI3K | -0.014 | 0.088 | -10000 | 0 | -0.27 | 15 | 15 |
GNAZ | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
SHBG | -0.005 | 0.08 | -10000 | 0 | -0.42 | 7 | 7 |
Gi family/GNB1/GNG2/GDP | -0.045 | 0.17 | -10000 | 0 | -0.46 | 21 | 21 |
mol:T-DHT | 0 | 0.001 | -10000 | 0 | -0.003 | 8 | 8 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNRH1 | 0.005 | 0.049 | -10000 | 0 | -0.48 | 2 | 2 |
Gi family/GTP | -0.056 | 0.14 | -10000 | 0 | -0.32 | 28 | 28 |
CDC42 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | -0.029 | 0.21 | -9999 | 0 | -0.69 | 7 | 7 |
CRP | -0.036 | 0.22 | -9999 | 0 | -0.69 | 7 | 7 |
cell cycle arrest | -0.048 | 0.24 | -9999 | 0 | -0.72 | 11 | 11 |
TIMP1 | -0.014 | 0.18 | -9999 | 0 | -0.62 | 3 | 3 |
IL6ST | -0.012 | 0.13 | -9999 | 0 | -0.64 | 8 | 8 |
Rac1/GDP | -0.063 | 0.2 | -9999 | 0 | -0.49 | 24 | 24 |
AP1 | 0.004 | 0.11 | -9999 | 0 | -0.46 | 5 | 5 |
GAB2 | 0.009 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
TNFSF11 | -0.1 | 0.37 | -9999 | 0 | -1 | 23 | 23 |
HSP90B1 | 0.022 | 0.043 | -9999 | 0 | -10000 | 0 | 0 |
GAB1 | 0.013 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | -0.039 | 0.18 | -9999 | 0 | -0.61 | 9 | 9 |
AKT1 | 0.047 | 0.025 | -9999 | 0 | -10000 | 0 | 0 |
FOXO1 | 0.052 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K6 | -0.048 | 0.19 | -9999 | 0 | -0.49 | 17 | 17 |
mol:GTP | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K4 | -0.05 | 0.21 | -9999 | 0 | -0.55 | 17 | 17 |
MITF | -0.072 | 0.21 | -9999 | 0 | -0.54 | 22 | 22 |
positive regulation of NF-kappaB transcription factor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TYK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
A2M | -0.007 | 0.18 | -9999 | 0 | -1.4 | 3 | 3 |
CEBPB | 0.017 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
GRB2/SOS1/GAB family/SHP2 | -0.003 | 0.099 | -9999 | 0 | -0.97 | 1 | 1 |
STAT3 | -0.055 | 0.25 | -9999 | 0 | -0.77 | 11 | 11 |
STAT1 | -0.008 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
CEBPD | -0.031 | 0.22 | -9999 | 0 | -0.77 | 6 | 6 |
PIK3CA | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JUN | 0.008 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
PIAS3/MITF | -0.062 | 0.2 | -9999 | 0 | -0.51 | 22 | 22 |
MAPK11 | -0.041 | 0.18 | -9999 | 0 | -0.61 | 9 | 9 |
STAT3 (dimer)/FOXO1 | 0.003 | 0.22 | -9999 | 0 | -0.72 | 7 | 7 |
GRB2/SOS1/GAB family | -0.077 | 0.17 | -9999 | 0 | -0.56 | 15 | 15 |
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/HCK | -0.073 | 0.22 | -9999 | 0 | -0.53 | 25 | 25 |
GRB2 | 0.013 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
JAK2 | 0.005 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
LBP | -0.087 | 0.28 | -9999 | 0 | -0.81 | 17 | 17 |
PIK3R1 | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JAK1 | 0.01 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
MYC | -0.037 | 0.24 | -9999 | 0 | -0.9 | 7 | 7 |
FGG | -0.041 | 0.22 | -9999 | 0 | -0.74 | 6 | 6 |
macrophage differentiation | -0.048 | 0.24 | -9999 | 0 | -0.72 | 11 | 11 |
IL6/IL6RA/gp130 (dimer)/JAK2/JAK2/LMO4 | -0.095 | 0.18 | -9999 | 0 | -0.41 | 36 | 36 |
JUNB | -0.028 | 0.2 | -9999 | 0 | -0.66 | 7 | 7 |
FOS | -0.026 | 0.14 | -9999 | 0 | -0.55 | 13 | 13 |
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 | -0.053 | 0.19 | -9999 | 0 | -0.51 | 18 | 18 |
STAT1/PIAS1 | -0.041 | 0.18 | -9999 | 0 | -0.52 | 14 | 14 |
GRB2/SOS1/GAB family/SHP2/PI3K | 0.037 | 0.027 | -9999 | 0 | -0.29 | 1 | 1 |
STAT3 (dimer) | -0.052 | 0.25 | -9999 | 0 | -0.76 | 11 | 11 |
PRKCD | -0.037 | 0.22 | -9999 | 0 | -0.6 | 13 | 13 |
IL6R | -0.006 | 0.11 | -9999 | 0 | -0.63 | 6 | 6 |
SOCS3 | -0.035 | 0.17 | -9999 | 0 | -0.92 | 3 | 3 |
gp130 (dimer)/JAK1/JAK1/LMO4 | 0.009 | 0.098 | -9999 | 0 | -0.4 | 9 | 9 |
Rac1/GTP | -0.062 | 0.21 | -9999 | 0 | -0.53 | 21 | 21 |
HCK | -0.041 | 0.17 | -9999 | 0 | -0.58 | 17 | 17 |
MAPKKK cascade | 0.015 | 0.087 | -9999 | 0 | -0.95 | 1 | 1 |
bone resorption | -0.093 | 0.34 | -9999 | 0 | -0.94 | 23 | 23 |
IRF1 | -0.03 | 0.21 | -9999 | 0 | -0.71 | 6 | 6 |
mol:GDP | -0.074 | 0.21 | -9999 | 0 | -0.52 | 24 | 24 |
SOS1 | 0.012 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
VAV1 | -0.076 | 0.22 | -9999 | 0 | -0.53 | 24 | 24 |
IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 | -0.05 | 0.2 | -9999 | 0 | -0.69 | 10 | 10 |
PTPN11 | -0.005 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
IL6/IL6RA | -0.1 | 0.22 | -9999 | 0 | -0.41 | 55 | 55 |
gp130 (dimer)/TYK2/TYK2/LMO4 | 0.006 | 0.091 | -9999 | 0 | -0.38 | 9 | 9 |
gp130 (dimer)/JAK2/JAK2/LMO4 | 0.002 | 0.096 | -9999 | 0 | -0.38 | 9 | 9 |
IL6 | -0.14 | 0.25 | -9999 | 0 | -0.53 | 54 | 54 |
PIAS3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTPRE | 0.007 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
PIAS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
IL6/IL6RA/gp130 (dimer)/TYK2/TYK2/LMO4 | -0.059 | 0.17 | -9999 | 0 | -0.36 | 36 | 36 |
LMO4 | 0.008 | 0.055 | -9999 | 0 | -0.42 | 3 | 3 |
STAT3 (dimer)/PIAS3 | -0.1 | 0.21 | -9999 | 0 | -0.73 | 11 | 11 |
MCL1 | 0.052 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
AKT1 | 0.024 | 0.26 | -10000 | 0 | -0.99 | 10 | 10 |
NCK1/PAK1/Dok-R | -0.037 | 0.11 | -10000 | 0 | -0.45 | 11 | 11 |
NCK1/Dok-R | -0.038 | 0.31 | -10000 | 0 | -1.2 | 11 | 11 |
PIK3CA | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:beta2-estradiol | 0 | 0.044 | 0.24 | 5 | -10000 | 0 | 5 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
Rac/GDP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
F2 | -0.083 | 0.2 | 0.25 | 3 | -0.48 | 36 | 39 |
TNIP2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NF kappa B/RelA | -0.067 | 0.25 | -10000 | 0 | -1.1 | 10 | 10 |
FN1 | -0.1 | 0.23 | -10000 | 0 | -0.54 | 40 | 40 |
PLD2 | -0.004 | 0.31 | -10000 | 0 | -1.2 | 10 | 10 |
PTPN11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB14 | -0.17 | 0.27 | -10000 | 0 | -0.54 | 63 | 63 |
ELK1 | 0.011 | 0.27 | -10000 | 0 | -1.1 | 10 | 10 |
GRB7 | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
PAK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Tie2/Ang1/alpha5/beta1 Integrin | -0.12 | 0.3 | -10000 | 0 | -1 | 15 | 15 |
CDKN1A | 0.028 | 0.22 | -10000 | 0 | -0.68 | 14 | 14 |
ITGA5 | -0.014 | 0.11 | -10000 | 0 | -0.48 | 10 | 10 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RasGAP/Dok-R | -0.038 | 0.31 | -10000 | 0 | -1.2 | 11 | 11 |
CRK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:NO | 0.035 | 0.21 | -10000 | 0 | -0.7 | 11 | 11 |
PLG | -0.01 | 0.31 | -10000 | 0 | -1.2 | 10 | 10 |
mol:GDP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
chemokinesis | 0.02 | 0.24 | -10000 | 0 | -0.93 | 10 | 10 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.013 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
ANGPT2 | -0.007 | 0.22 | -10000 | 0 | -0.81 | 8 | 8 |
BMX | -0.063 | 0.35 | -10000 | 0 | -1.2 | 12 | 12 |
ANGPT1 | -0.003 | 0.25 | -10000 | 0 | -1.1 | 7 | 7 |
tube development | 0.022 | 0.23 | -10000 | 0 | -0.74 | 12 | 12 |
ANGPT4 | 0 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
response to hypoxia | -0.001 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
Tie2/Ang1/GRB14 | -0.1 | 0.33 | -10000 | 0 | -1.3 | 10 | 10 |
alpha5/beta1 Integrin | -0.001 | 0.081 | -10000 | 0 | -0.34 | 10 | 10 |
FGF2 | -0.037 | 0.16 | -10000 | 0 | -0.53 | 17 | 17 |
STAT5A (dimer) | 0.02 | 0.26 | -10000 | 0 | -0.83 | 14 | 14 |
mol:L-citrulline | 0.035 | 0.21 | -10000 | 0 | -0.7 | 11 | 11 |
AGTR1 | -0.14 | 0.24 | -10000 | 0 | -0.52 | 54 | 54 |
MAPK14 | -0.003 | 0.31 | -10000 | 0 | -1.3 | 10 | 10 |
Tie2/SHP2 | -0.054 | 0.24 | -10000 | 0 | -1 | 9 | 9 |
TEK | -0.026 | 0.27 | -10000 | 0 | -1.2 | 9 | 9 |
RPS6KB1 | 0.027 | 0.25 | -10000 | 0 | -0.94 | 10 | 10 |
Angiotensin II/AT1 | -0.099 | 0.18 | -10000 | 0 | -0.38 | 54 | 54 |
Tie2/Ang1/GRB2 | -0.008 | 0.32 | -10000 | 0 | -1.3 | 10 | 10 |
MAPK3 | 0.006 | 0.28 | -10000 | 0 | -1.1 | 10 | 10 |
MAPK1 | 0.006 | 0.28 | -10000 | 0 | -1.1 | 10 | 10 |
Tie2/Ang1/GRB7 | -0.009 | 0.32 | -10000 | 0 | -1.3 | 10 | 10 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | -0.004 | 0.31 | -10000 | 0 | -1.2 | 10 | 10 |
PI3K | 0.011 | 0.3 | -10000 | 0 | -1.2 | 10 | 10 |
FES | -0.007 | 0.33 | -10000 | 0 | -1.3 | 10 | 10 |
Crk/Dok-R | -0.038 | 0.31 | -10000 | 0 | -1.2 | 11 | 11 |
Tie2/Ang1/ABIN2 | -0.008 | 0.32 | -10000 | 0 | -1.3 | 10 | 10 |
blood circulation | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
negative regulation of caspase activity | 0.03 | 0.24 | -10000 | 0 | -0.86 | 10 | 10 |
STAT5A | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:ROS | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTK2 | 0.027 | 0.25 | -10000 | 0 | -0.94 | 10 | 10 |
Tie2/Ang2 | 0.001 | 0.31 | -10000 | 0 | -1.1 | 12 | 12 |
Tie2/Ang1 | -0.013 | 0.34 | -10000 | 0 | -1.4 | 10 | 10 |
FOXO1 | 0.032 | 0.24 | -10000 | 0 | -0.83 | 12 | 12 |
ELF1 | 0.016 | 0.022 | -10000 | 0 | -10000 | 0 | 0 |
ELF2 | -0.007 | 0.31 | -10000 | 0 | -1.2 | 10 | 10 |
mol:Choline | 0 | 0.29 | -10000 | 0 | -1.2 | 10 | 10 |
cell migration | -0.032 | 0.068 | -10000 | 0 | -0.24 | 12 | 12 |
FYN | 0.015 | 0.26 | -10000 | 0 | -0.86 | 12 | 12 |
DOK2 | -0.024 | 0.14 | -10000 | 0 | -0.56 | 12 | 12 |
negative regulation of cell cycle | 0.031 | 0.2 | -10000 | 0 | -0.61 | 14 | 14 |
ETS1 | -0.006 | 0.12 | -10000 | 0 | -0.57 | 7 | 7 |
PXN | 0.039 | 0.21 | -10000 | 0 | -0.75 | 10 | 10 |
ITGB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NOS3 | 0.029 | 0.23 | -10000 | 0 | -0.81 | 11 | 11 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TNF | -0.016 | 0.14 | -10000 | 0 | -0.57 | 10 | 10 |
MAPKKK cascade | 0 | 0.29 | -10000 | 0 | -1.2 | 10 | 10 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Tie2/Ang1/Shc | -0.007 | 0.32 | -10000 | 0 | -1.3 | 10 | 10 |
NCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
vasculogenesis | 0.038 | 0.19 | -10000 | 0 | -0.62 | 11 | 11 |
mol:Phosphatidic acid | 0 | 0.29 | -10000 | 0 | -1.2 | 10 | 10 |
mol:Angiotensin II | 0.001 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
mol:NADP | 0.035 | 0.21 | -10000 | 0 | -0.7 | 11 | 11 |
Rac1/GTP | -0.057 | 0.2 | -10000 | 0 | -0.87 | 10 | 10 |
MMP2 | -0.031 | 0.34 | -10000 | 0 | -1.3 | 11 | 11 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
mol:K + | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAT1/GTP | 0.002 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
Metarhodopsin II/Arrestin | 0.003 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
PDE6G/GNAT1/GTP | -0.018 | 0.097 | -9999 | 0 | -0.34 | 15 | 15 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
absorption of light | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAT1 | 0.003 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
GRK1 | 0 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
CNG Channel | -0.13 | 0.18 | -9999 | 0 | -0.39 | 51 | 51 |
mol:Na + | -0.076 | 0.14 | -9999 | 0 | -0.51 | 8 | 8 |
mol:ADP | 0 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
RGS9-1/Gbeta5/R9AP | -0.023 | 0.13 | -9999 | 0 | -0.44 | 13 | 13 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cGMP/CNG Channel | -0.078 | 0.14 | -9999 | 0 | -0.53 | 8 | 8 |
CNGB1 | 0 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
RDH5 | -0.001 | 0.084 | -9999 | 0 | -0.5 | 5 | 5 |
SAG | 0.002 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.049 | 0.14 | -9999 | 0 | -0.54 | 6 | 6 |
Na + (4 Units) | -0.07 | 0.13 | -9999 | 0 | -0.5 | 7 | 7 |
RGS9 | -0.046 | 0.17 | -9999 | 0 | -0.52 | 21 | 21 |
GNB1/GNGT1 | 0.002 | 0.062 | -9999 | 0 | -0.31 | 7 | 7 |
GNAT1/GDP | -0.018 | 0.11 | -9999 | 0 | -0.38 | 13 | 13 |
GUCY2D | -0.016 | 0.099 | -9999 | 0 | -0.42 | 11 | 11 |
GNGT1 | -0.01 | 0.086 | -9999 | 0 | -0.45 | 7 | 7 |
GUCY2F | 0.001 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
GNB5 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
mol:GMP (4 units) | -0.086 | 0.17 | -9999 | 0 | -0.38 | 38 | 38 |
mol:11-cis-retinal | -0.001 | 0.084 | -9999 | 0 | -0.5 | 5 | 5 |
mol:cGMP | -0.023 | 0.11 | -9999 | 0 | -0.36 | 11 | 11 |
GNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rhodopsin | 0 | 0.061 | -9999 | 0 | -0.36 | 5 | 5 |
SLC24A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CNGA1 | -0.079 | 0.2 | -9999 | 0 | -0.5 | 34 | 34 |
Metarhodopsin II | 0.001 | 0.016 | -9999 | 0 | -0.22 | 1 | 1 |
mol:Ca ++ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GC1/GCAP Family | -0.025 | 0.11 | -9999 | 0 | -0.39 | 11 | 11 |
RGS9BP | 0.003 | 0.063 | -9999 | 0 | -0.49 | 3 | 3 |
Metarhodopsin II/Transducin | 0.005 | 0.031 | -9999 | 0 | -0.28 | 1 | 1 |
GCAP Family/Ca ++ | -0.017 | 0.099 | -9999 | 0 | -0.37 | 11 | 11 |
PDE6A/B | -0.099 | 0.19 | -9999 | 0 | -0.38 | 56 | 56 |
mol:Pi | -0.023 | 0.13 | -9999 | 0 | -0.44 | 13 | 13 |
mol:all-trans-retinal | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Transducin | 0.005 | 0.048 | -9999 | 0 | -0.36 | 1 | 1 |
PDE6B | -0.028 | 0.15 | -9999 | 0 | -0.54 | 14 | 14 |
PDE6A | -0.11 | 0.23 | -9999 | 0 | -0.52 | 44 | 44 |
PDE6G | -0.032 | 0.15 | -9999 | 0 | -0.55 | 15 | 15 |
RHO | 0.001 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
PDE6 | -0.13 | 0.18 | -9999 | 0 | -0.56 | 15 | 15 |
GUCA1A | -0.007 | 0.087 | -9999 | 0 | -0.45 | 7 | 7 |
GC2/GCAP Family | -0.017 | 0.099 | -9999 | 0 | -0.37 | 11 | 11 |
GUCA1C | -0.002 | 0.03 | -9999 | 0 | -0.42 | 1 | 1 |
GUCA1B | -0.025 | 0.14 | -9999 | 0 | -0.58 | 12 | 12 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Ephrin A5/EPHB2 | -0.067 | 0.16 | -10000 | 0 | -0.36 | 42 | 42 |
cell-cell adhesion | 0.068 | 0.11 | 0.49 | 5 | -10000 | 0 | 5 |
Ephrin B/EPHB2/RasGAP | 0.002 | 0.11 | -10000 | 0 | -0.38 | 11 | 11 |
ITSN1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B1/EPHB3 | 0.004 | 0.067 | -10000 | 0 | -0.33 | 7 | 7 |
Ephrin B1/EPHB1 | -0.062 | 0.14 | -10000 | 0 | -0.28 | 51 | 51 |
HRAS/GDP | -0.066 | 0.11 | -10000 | 0 | -0.46 | 4 | 4 |
Ephrin B/EPHB1/GRB7 | -0.06 | 0.15 | -10000 | 0 | -0.36 | 22 | 22 |
Endophilin/SYNJ1 | 0.001 | 0.1 | -10000 | 0 | -0.35 | 11 | 11 |
KRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B/EPHB1/Src | -0.058 | 0.14 | -10000 | 0 | -0.36 | 21 | 21 |
endothelial cell migration | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GRB7 | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
PAK1 | 0.004 | 0.12 | -10000 | 0 | -0.41 | 11 | 11 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RRAS | 0.001 | 0.1 | -10000 | 0 | -0.36 | 11 | 11 |
DNM1 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
cell-cell signaling | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRK | -0.055 | 0.13 | -10000 | 0 | -0.34 | 21 | 21 |
lamellipodium assembly | -0.068 | 0.11 | -10000 | 0 | -0.49 | 5 | 5 |
Ephrin B/EPHB1/Src/p52 SHC/GRB2 | -0.027 | 0.1 | -10000 | 0 | -0.29 | 14 | 14 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EPHB2 | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
EPHB3 | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
EPHB1 | -0.12 | 0.22 | -10000 | 0 | -0.47 | 51 | 51 |
EPHB4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.034 | 0.12 | -10000 | 0 | -0.38 | 9 | 9 |
Ephrin B/EPHB2 | -0.005 | 0.11 | -10000 | 0 | -0.38 | 11 | 11 |
Ephrin B/EPHB3 | -0.009 | 0.1 | -10000 | 0 | -0.35 | 12 | 12 |
JNK cascade | -0.039 | 0.13 | -10000 | 0 | -0.34 | 16 | 16 |
Ephrin B/EPHB1 | -0.065 | 0.14 | -10000 | 0 | -0.36 | 21 | 21 |
RAP1/GDP | -0.019 | 0.11 | -10000 | 0 | -0.42 | 3 | 3 |
EFNB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EFNB3 | -0.037 | 0.16 | -10000 | 0 | -0.51 | 18 | 18 |
EFNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B2/EPHB1-2 | -0.056 | 0.14 | -10000 | 0 | -0.38 | 16 | 16 |
RAP1B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDC42/GTP | -0.071 | 0.12 | -10000 | 0 | -0.55 | 5 | 5 |
Rap1/GTP | -0.067 | 0.11 | -10000 | 0 | -0.5 | 5 | 5 |
axon guidance | -0.067 | 0.16 | -10000 | 0 | -0.36 | 42 | 42 |
MAPK3 | -0.011 | 0.091 | -10000 | 0 | -0.37 | 2 | 2 |
MAPK1 | -0.011 | 0.091 | -10000 | 0 | -0.37 | 2 | 2 |
Rac1/GDP | -0.024 | 0.12 | -10000 | 0 | -0.42 | 4 | 4 |
actin cytoskeleton reorganization | -0.053 | 0.088 | -10000 | 0 | -0.4 | 5 | 5 |
CDC42/GDP | -0.024 | 0.12 | -10000 | 0 | -0.42 | 4 | 4 |
PI3K | 0.028 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EFNA5 | -0.11 | 0.24 | -10000 | 0 | -0.57 | 39 | 39 |
Ephrin B2/EPHB4 | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B/EPHB2/Intersectin/N-WASP | 0.008 | 0.085 | -10000 | 0 | -0.3 | 11 | 11 |
CDC42 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP | -0.066 | 0.11 | -10000 | 0 | -0.48 | 5 | 5 |
PTK2 | 0.019 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
MAP4K4 | -0.039 | 0.13 | -10000 | 0 | -0.35 | 16 | 16 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KALRN | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
Intersectin/N-WASP | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
neuron projection morphogenesis | -0.011 | 0.12 | -10000 | 0 | -0.46 | 5 | 5 |
MAP2K1 | -0.018 | 0.095 | -10000 | 0 | -0.4 | 2 | 2 |
WASL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin B1/EPHB1-2/NCK1 | -0.049 | 0.14 | -10000 | 0 | -0.38 | 16 | 16 |
cell migration | -0.017 | 0.11 | -10000 | 0 | -0.46 | 2 | 2 |
NRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SYNJ1 | 0.001 | 0.1 | -10000 | 0 | -0.36 | 11 | 11 |
PXN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TF | -0.041 | 0.14 | -10000 | 0 | -0.46 | 7 | 7 |
HRAS/GTP | -0.074 | 0.12 | -10000 | 0 | -0.49 | 6 | 6 |
Ephrin B1/EPHB1-2 | -0.056 | 0.14 | -10000 | 0 | -0.38 | 16 | 16 |
cell adhesion mediated by integrin | 0.013 | 0.088 | 0.33 | 9 | -10000 | 0 | 9 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | -0.055 | 0.14 | -10000 | 0 | -0.36 | 23 | 23 |
RAC1-CDC42/GTP | -0.074 | 0.12 | -10000 | 0 | -0.48 | 6 | 6 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1-CDC42/GDP | -0.019 | 0.11 | -10000 | 0 | -0.42 | 3 | 3 |
ruffle organization | -0.032 | 0.13 | -10000 | 0 | -0.5 | 5 | 5 |
NCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
receptor internalization | 0 | 0.11 | -10000 | 0 | -0.51 | 4 | 4 |
Ephrin B/EPHB2/KALRN | -0.002 | 0.13 | -10000 | 0 | -0.44 | 11 | 11 |
ROCK1 | 0.009 | 0.066 | -10000 | 0 | -0.36 | 5 | 5 |
RAS family/GDP | -0.048 | 0.085 | -10000 | 0 | -0.4 | 5 | 5 |
Rac1/GTP | -0.072 | 0.12 | -10000 | 0 | -0.52 | 5 | 5 |
Ephrin B/EPHB1/Src/Paxillin | -0.033 | 0.11 | -10000 | 0 | -0.29 | 20 | 20 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NRIP1 | 0.003 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
SVIL | -0.007 | 0.08 | -9999 | 0 | -0.53 | 4 | 4 |
ZNF318 | 0.037 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
JMJD2C | 0.005 | 0.018 | -9999 | 0 | -0.071 | 8 | 8 |
T-DHT/AR/Ubc9 | -0.048 | 0.14 | -9999 | 0 | -0.31 | 38 | 38 |
CARM1 | 0.011 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
PRDX1 | 0.014 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
PELP1 | 0.016 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.005 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | 0.019 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
PTK2B | 0.005 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
MED1 | 0.017 | 0.035 | -9999 | 0 | -0.42 | 1 | 1 |
MAK | 0.015 | 0.12 | -9999 | 0 | -0.48 | 8 | 8 |
response to oxidative stress | 0.002 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
HIP1 | 0.004 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
GSN | -0.007 | 0.073 | -9999 | 0 | -0.48 | 4 | 4 |
NCOA2 | 0.004 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
NCOA6 | 0.004 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
DNA-PK | 0.033 | 0.061 | -9999 | 0 | -0.29 | 1 | 1 |
NCOA4 | 0.011 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
PIAS3 | 0.005 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
cell proliferation | -0.002 | 0.12 | -9999 | 0 | -0.78 | 3 | 3 |
XRCC5 | 0.017 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
UBE3A | -0.003 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/SNURF | -0.1 | 0.19 | -9999 | 0 | -0.42 | 42 | 42 |
FHL2 | 0.017 | 0.12 | -9999 | 0 | -1.3 | 1 | 1 |
RANBP9 | 0.004 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
JMJD1A | -0.005 | 0.043 | -9999 | 0 | -0.11 | 23 | 23 |
CDK6 | 0.011 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
TGFB1I1 | -0.001 | 0.048 | -9999 | 0 | -0.42 | 2 | 2 |
T-DHT/AR/CyclinD1 | -0.057 | 0.14 | -9999 | 0 | -0.36 | 24 | 24 |
XRCC6 | 0.017 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR | -0.043 | 0.15 | -9999 | 0 | -0.39 | 21 | 21 |
CTDSP1 | 0.008 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
CTDSP2 | 0.028 | 0.034 | -9999 | 0 | -10000 | 0 | 0 |
BRCA1 | 0.004 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
TCF4 | 0.001 | 0.12 | -9999 | 0 | -0.59 | 7 | 7 |
CDKN2A | -0.048 | 0.18 | -9999 | 0 | -0.48 | 26 | 26 |
SRF | 0.026 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
NKX3-1 | -0.083 | 0.24 | -9999 | 0 | -0.82 | 15 | 15 |
KLK3 | -0.2 | 0.45 | -9999 | 0 | -1.4 | 21 | 21 |
TMF1 | 0.009 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
HNRNPA1 | 0.02 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
AOF2 | -0.01 | 0.023 | -9999 | 0 | -0.07 | 21 | 21 |
APPL1 | 0.035 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/Caspase 8 | -0.04 | 0.14 | -9999 | 0 | -0.34 | 26 | 26 |
AR | -0.097 | 0.21 | -9999 | 0 | -0.5 | 40 | 40 |
UBA3 | 0.008 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
PATZ1 | 0.02 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
PAWR | 0.009 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
PRKDC | 0.014 | 0.045 | -9999 | 0 | -0.58 | 1 | 1 |
PA2G4 | 0.023 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
UBE2I | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/Cyclin D3/CDK11 p58 | -0.038 | 0.13 | -9999 | 0 | -0.34 | 21 | 21 |
RPS6KA3 | 0.003 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/ARA70 | -0.055 | 0.14 | -9999 | 0 | -0.37 | 22 | 22 |
LATS2 | 0.017 | 0.05 | -9999 | 0 | -0.62 | 1 | 1 |
T-DHT/AR/PRX1 | -0.031 | 0.13 | -9999 | 0 | -0.34 | 21 | 21 |
Cyclin D3/CDK11 p58 | 0.009 | 0.022 | -9999 | 0 | -0.29 | 1 | 1 |
VAV3 | -0.11 | 0.25 | -9999 | 0 | -0.63 | 36 | 36 |
KLK2 | -0.032 | 0.088 | -9999 | 0 | -0.44 | 3 | 3 |
CASP8 | 0.015 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/TIF2/CARM1 | -0.048 | 0.14 | -9999 | 0 | -0.38 | 18 | 18 |
TMPRSS2 | -0.029 | 0.12 | -9999 | 0 | -1.2 | 1 | 1 |
CCND1 | 0.008 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
PIAS1 | -0.003 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
mol:T-DHT | -0.002 | 0.021 | -9999 | 0 | -0.067 | 10 | 10 |
CDC2L1 | 0.001 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
PIAS4 | -0.011 | 0.05 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/CDK6 | -0.047 | 0.14 | -9999 | 0 | -0.37 | 21 | 21 |
CMTM2 | -0.028 | 0.15 | -9999 | 0 | -0.53 | 15 | 15 |
SNURF | -0.075 | 0.21 | -9999 | 0 | -0.59 | 27 | 27 |
ZMIZ1 | 0.011 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
CCND3 | 0.011 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
TGIF1 | 0.02 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
FKBP4 | 0.002 | 0.038 | -9999 | 0 | -0.44 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
SPHK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SPHK1 | -0.049 | 0.18 | -9999 | 0 | -0.54 | 21 | 21 |
GNAI2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:S1P | -0.007 | 0.084 | -9999 | 0 | -0.31 | 12 | 12 |
GNAO1 | -0.099 | 0.22 | -9999 | 0 | -0.53 | 39 | 39 |
mol:Sphinganine-1-P | -0.024 | 0.13 | -9999 | 0 | -0.39 | 21 | 21 |
growth factor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1P/S1P2/G12/G13 | 0.015 | 0.063 | -9999 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G12/G13 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1PR3 | 0 | 0.086 | -9999 | 0 | -0.58 | 4 | 4 |
S1PR2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EDG1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1P1/S1P | -0.022 | 0.067 | -9999 | 0 | -0.27 | 12 | 12 |
S1PR5 | -0.002 | 0.092 | -9999 | 0 | -0.64 | 4 | 4 |
S1PR4 | -0.03 | 0.15 | -9999 | 0 | -0.56 | 14 | 14 |
GNAI1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
S1P/S1P5/G12 | 0 | 0.083 | -9999 | 0 | -0.35 | 4 | 4 |
S1P/S1P3/Gq | -0.01 | 0.12 | -9999 | 0 | -0.36 | 16 | 16 |
S1P/S1P4/Gi | -0.05 | 0.16 | -9999 | 0 | -0.37 | 28 | 28 |
GNAQ | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
GNAZ | -0.008 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
GNA14 | -0.011 | 0.12 | -9999 | 0 | -0.6 | 7 | 7 |
GNA15 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
GNA12 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA13 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ABCC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HDAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HDAC3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VDR | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
Cbp/p300/PCAF | 0.02 | 0.042 | -10000 | 0 | -0.39 | 2 | 2 |
EP300 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
RARs/AIB1/Cbp/p300/PCAF/9cRA | 0.01 | 0.061 | -10000 | 0 | -0.32 | 2 | 2 |
KAT2B | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
MAPK14 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT1 | 0.012 | 0.079 | 0.22 | 2 | -0.3 | 4 | 6 |
RAR alpha/9cRA/Cyclin H | -0.037 | 0.072 | -10000 | 0 | -0.3 | 2 | 2 |
mol:9cRA | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RARs/Src-1/Cbp/p300/PCAF/9cRA | 0.006 | 0.063 | -10000 | 0 | -0.3 | 3 | 3 |
CDC2 | 0.001 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to UV | 0.001 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAR alpha/Jnk1 | -0.025 | 0.077 | -10000 | 0 | -10000 | 0 | 0 |
NCOR2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
VDR/VDR/Vit D3 | 0.006 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
RXRs/RARs/NRIP1/9cRA | -0.033 | 0.16 | -10000 | 0 | -0.42 | 23 | 23 |
NCOA2 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
NCOA3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NCOA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VDR/VDR/DNA | 0.009 | 0.046 | -10000 | 0 | -0.63 | 1 | 1 |
RARG | 0.009 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
RAR gamma1/9cRA | 0.015 | 0.03 | -10000 | 0 | -0.4 | 1 | 1 |
MAPK3 | 0.013 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.013 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Vit D3 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RXRs/VDR/DNA/Vit D3 | -0.068 | 0.15 | -10000 | 0 | -0.45 | 23 | 23 |
RARA | -0.033 | 0.098 | -10000 | 0 | -0.26 | 23 | 23 |
negative regulation of phosphoinositide 3-kinase cascade | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RARs/TIF2/Cbp/p300/PCAF/9cRA | 0.004 | 0.072 | -10000 | 0 | -0.38 | 3 | 3 |
PRKCA | 0.008 | 0.066 | -10000 | 0 | -0.63 | 2 | 2 |
RXRs/RARs/NRIP1/9cRA/HDAC1 | -0.042 | 0.16 | -10000 | 0 | -0.43 | 23 | 23 |
RXRG | -0.069 | 0.14 | -10000 | 0 | -0.37 | 24 | 24 |
RXRA | -0.021 | 0.089 | -10000 | 0 | -0.27 | 2 | 2 |
RXRB | -0.056 | 0.13 | -10000 | 0 | -0.36 | 23 | 23 |
VDR/Vit D3/DNA | 0.006 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
RBP1 | -0.096 | 0.2 | -10000 | 0 | -0.45 | 45 | 45 |
CRBP1/9-cic-RA | -0.068 | 0.14 | -10000 | 0 | -0.32 | 45 | 45 |
RARB | -0.006 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
PRKCG | -0.14 | 0.24 | -10000 | 0 | -0.49 | 60 | 60 |
MNAT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAR alpha/RXRs | -0.028 | 0.17 | -10000 | 0 | -0.45 | 23 | 23 |
RXRs/RARs/SMRT(N-CoR2)/9cRA | -0.027 | 0.15 | -10000 | 0 | -0.38 | 23 | 23 |
proteasomal ubiquitin-dependent protein catabolic process | -0.005 | 0.081 | -10000 | 0 | -0.34 | 2 | 2 |
RXRs/RARs/NRIP1/9cRA/HDAC3 | -0.042 | 0.16 | -10000 | 0 | -0.43 | 23 | 23 |
positive regulation of DNA binding | -0.035 | 0.069 | -10000 | 0 | -0.29 | 2 | 2 |
NRIP1 | -0.036 | 0.14 | -10000 | 0 | -0.63 | 1 | 1 |
RXRs/RARs | -0.047 | 0.16 | -10000 | 0 | -0.43 | 23 | 23 |
RXRs/RXRs/DNA/9cRA | -0.071 | 0.16 | -10000 | 0 | -0.47 | 23 | 23 |
PRKACA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDK7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TFIIH | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAR alpha/9cRA | -0.026 | 0.049 | -10000 | 0 | -10000 | 0 | 0 |
CCNH | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAR gamma2/9cRA | -0.002 | 0.022 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GAB2 | 0.009 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
ELF1 | -0.021 | 0.11 | -9999 | 0 | -0.36 | 15 | 15 |
CCNA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
JAK3 | 0.002 | 0.07 | -9999 | 0 | -0.47 | 4 | 4 |
PIK3R1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
JAK1 | 0.009 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K | 0.009 | 0.14 | -9999 | 0 | -0.43 | 13 | 13 |
SHC1 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
SP1 | -0.018 | 0.11 | -9999 | 0 | -0.36 | 18 | 18 |
IL2RA | -0.061 | 0.25 | -9999 | 0 | -0.66 | 25 | 25 |
IL2RB | -0.04 | 0.17 | -9999 | 0 | -0.55 | 18 | 18 |
SOS1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
IL2RG | 0.005 | 0.063 | -9999 | 0 | -0.49 | 3 | 3 |
G1/S transition of mitotic cell cycle | -0.035 | 0.22 | -9999 | 0 | -0.71 | 18 | 18 |
PTPN11 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
CCND2 | -0.06 | 0.26 | -9999 | 0 | -0.81 | 20 | 20 |
LCK | -0.05 | 0.16 | -9999 | 0 | -0.47 | 25 | 25 |
GRB2 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
IL2 | 0.002 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
CDK6 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
CCND3 | 0.017 | 0.12 | -9999 | 0 | -0.48 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ARF5/GTP | -0.006 | 0.055 | 0.26 | 2 | -10000 | 0 | 2 |
DAPP1 | -0.07 | 0.2 | -10000 | 0 | -0.61 | 17 | 17 |
Src family/SYK family/BLNK-LAT/BTK-ITK | -0.081 | 0.25 | -10000 | 0 | -0.68 | 22 | 22 |
mol:DAG | -0.019 | 0.11 | 0.19 | 1 | -0.29 | 19 | 20 |
HRAS | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
RAP1A | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
ARF5/GDP | -0.013 | 0.13 | -10000 | 0 | -0.49 | 9 | 9 |
PLCG2 | -0.036 | 0.16 | -10000 | 0 | -0.57 | 16 | 16 |
PLCG1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | -0.005 | 0.052 | 0.24 | 2 | -0.28 | 5 | 7 |
ARF1/GTP | -0.006 | 0.053 | 0.25 | 2 | -10000 | 0 | 2 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YES1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAP1A/GTP | -0.005 | 0.051 | 0.23 | 2 | -0.28 | 5 | 7 |
ADAP1 | -0.004 | 0.049 | 0.23 | 2 | -10000 | 0 | 2 |
ARAP3 | -0.005 | 0.052 | 0.24 | 2 | -0.28 | 5 | 7 |
INPPL1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PREX1 | -0.001 | 0.084 | -10000 | 0 | -0.5 | 5 | 5 |
ARHGEF6 | -0.01 | 0.11 | -10000 | 0 | -0.52 | 8 | 8 |
ARHGEF7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NRAS | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
FYN | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
ARF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FGR | -0.041 | 0.17 | -10000 | 0 | -0.55 | 18 | 18 |
mol:Ca2+ | -0.001 | 0.059 | -10000 | 0 | -0.21 | 1 | 1 |
mol:IP4 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TIAM1 | -0.075 | 0.2 | -10000 | 0 | -0.53 | 31 | 31 |
ZAP70 | -0.03 | 0.15 | -10000 | 0 | -0.56 | 14 | 14 |
mol:IP3 | -0.006 | 0.082 | -10000 | 0 | -0.23 | 8 | 8 |
LYN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF1/GDP | -0.013 | 0.13 | -10000 | 0 | -0.49 | 9 | 9 |
RhoA/GDP | -0.021 | 0.068 | -10000 | 0 | -0.45 | 1 | 1 |
PDK1/Src/Hsp90 | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BLNK | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
actin cytoskeleton reorganization | 0.007 | 0.11 | -10000 | 0 | -0.46 | 4 | 4 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLEKHA2 | 0.011 | 0.078 | -10000 | 0 | -0.39 | 7 | 7 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTEN | -0.005 | 0.062 | -10000 | 0 | -0.61 | 2 | 2 |
HSP90AA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GTP | -0.004 | 0.049 | 0.26 | 2 | -10000 | 0 | 2 |
RhoA/GTP | -0.005 | 0.049 | 0.23 | 2 | -10000 | 0 | 2 |
Src family/SYK family/BLNK-LAT | -0.076 | 0.22 | -10000 | 0 | -0.6 | 23 | 23 |
BLK | -0.13 | 0.23 | -10000 | 0 | -0.49 | 52 | 52 |
PDPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CYTH1 | -0.004 | 0.049 | 0.23 | 2 | -10000 | 0 | 2 |
HCK | -0.041 | 0.17 | -10000 | 0 | -0.58 | 17 | 17 |
CYTH3 | -0.007 | 0.054 | 0.23 | 2 | -0.3 | 1 | 3 |
CYTH2 | -0.004 | 0.049 | 0.23 | 2 | -10000 | 0 | 2 |
KRAS | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
GO:0030676 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO3 | 0.031 | 0.051 | -10000 | 0 | -0.47 | 1 | 1 |
SGK1 | -0.006 | 0.05 | 0.2 | 2 | -0.51 | 1 | 3 |
INPP5D | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
mol:GDP | -0.021 | 0.13 | -10000 | 0 | -0.49 | 10 | 10 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SYK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GDP | -0.021 | 0.068 | -10000 | 0 | -0.36 | 3 | 3 |
mol:PI-3-4-5-P3 | -0.004 | 0.055 | 0.31 | 2 | -0.28 | 5 | 7 |
ARAP3/RAP1A/GTP | -0.005 | 0.051 | 0.23 | 2 | -0.28 | 5 | 7 |
VAV1 | -0.052 | 0.19 | -10000 | 0 | -0.6 | 20 | 20 |
mol:PI-3-4-P2 | 0.002 | 0.091 | -10000 | 0 | -0.47 | 7 | 7 |
RAS family/GTP/PI3K Class I | 0.02 | 0.05 | -10000 | 0 | -0.28 | 5 | 5 |
PLEKHA1 | 0.011 | 0.078 | -10000 | 0 | -0.39 | 7 | 7 |
Rac1/GDP | -0.013 | 0.13 | -10000 | 0 | -0.49 | 9 | 9 |
LAT | -0.015 | 0.12 | -10000 | 0 | -0.5 | 10 | 10 |
Rac1/GTP | -0.036 | 0.17 | -10000 | 0 | -0.49 | 18 | 18 |
ITK | -0.029 | 0.092 | 0.23 | 1 | -0.33 | 11 | 12 |
Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma | -0.035 | 0.16 | 0.21 | 1 | -0.42 | 19 | 20 |
LCK | -0.051 | 0.16 | -10000 | 0 | -0.47 | 25 | 25 |
BTK | -0.034 | 0.098 | 0.23 | 1 | -0.32 | 14 | 15 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PDGFRB | -0.017 | 0.13 | -9999 | 0 | -0.61 | 9 | 9 |
mol:S1P | 0 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
S1P1/S1P/Gi | -0.029 | 0.12 | -9999 | 0 | -0.29 | 29 | 29 |
GNAO1 | -0.099 | 0.23 | -9999 | 0 | -0.54 | 39 | 39 |
S1P/S1P3/G12/G13 | 0.017 | 0.053 | -9999 | 0 | -0.34 | 4 | 4 |
AKT1 | -0.023 | 0.16 | -9999 | 0 | -0.71 | 8 | 8 |
AKT3 | -0.039 | 0.26 | -9999 | 0 | -1.3 | 7 | 7 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB | -0.017 | 0.13 | -9999 | 0 | -0.61 | 9 | 9 |
GNAI2 | 0.013 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1PR3 | 0 | 0.088 | -9999 | 0 | -0.59 | 4 | 4 |
S1PR2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EDG1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.038 | 0.17 | -9999 | 0 | -0.4 | 24 | 24 |
MAPK3 | -0.03 | 0.16 | -9999 | 0 | -0.57 | 10 | 10 |
MAPK1 | -0.03 | 0.16 | -9999 | 0 | -0.57 | 10 | 10 |
JAK2 | -0.04 | 0.19 | -9999 | 0 | -0.54 | 16 | 16 |
CXCR4 | -0.054 | 0.21 | -9999 | 0 | -0.57 | 19 | 19 |
FLT1 | 0.007 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
RhoA/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | -0.03 | 0.16 | -9999 | 0 | -0.57 | 10 | 10 |
S1P/S1P3/Gi | -0.038 | 0.17 | -9999 | 0 | -0.41 | 24 | 24 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GTP | -0.03 | 0.16 | -9999 | 0 | -0.56 | 10 | 10 |
VEGFA | 0.014 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
S1P/S1P2/Gi | -0.029 | 0.13 | -9999 | 0 | -0.32 | 24 | 24 |
VEGFR1 homodimer/VEGFA homodimer | 0.018 | 0.051 | -9999 | 0 | -0.47 | 2 | 2 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1P/S1P3/Gq | -0.005 | 0.11 | -9999 | 0 | -0.33 | 16 | 16 |
GNAQ | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
GNAZ | -0.008 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
G12/G13 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA14 | -0.011 | 0.12 | -9999 | 0 | -0.6 | 7 | 7 |
GNA15 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
GNA12 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA13 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.03 | 0.16 | -9999 | 0 | -0.56 | 10 | 10 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
mol:S1P | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAO1 | -0.099 | 0.22 | -9999 | 0 | -0.53 | 39 | 39 |
CDC42/GTP | -0.038 | 0.14 | -9999 | 0 | -0.54 | 7 | 7 |
PLCG1 | -0.038 | 0.14 | -9999 | 0 | -0.56 | 7 | 7 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAI2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G12/G13 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cell migration | -0.061 | 0.12 | -9999 | 0 | -0.53 | 7 | 7 |
S1PR5 | -0.002 | 0.092 | -9999 | 0 | -0.64 | 4 | 4 |
S1PR4 | -0.03 | 0.15 | -9999 | 0 | -0.56 | 14 | 14 |
MAPK3 | -0.038 | 0.14 | -9999 | 0 | -0.56 | 7 | 7 |
MAPK1 | -0.038 | 0.14 | -9999 | 0 | -0.56 | 7 | 7 |
S1P/S1P5/Gi | -0.036 | 0.14 | -9999 | 0 | -0.33 | 24 | 24 |
GNAI1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
CDC42/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
S1P/S1P5/G12 | 0.008 | 0.06 | -9999 | 0 | -0.4 | 4 | 4 |
RHOA | 0.006 | 0.082 | -9999 | 0 | -0.33 | 9 | 9 |
S1P/S1P4/Gi | -0.048 | 0.15 | -9999 | 0 | -0.35 | 28 | 28 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAZ | -0.008 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
S1P/S1P4/G12/G13 | -0.001 | 0.088 | -9999 | 0 | -0.36 | 9 | 9 |
GNA12 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNA13 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PLK2 | -0.009 | 0.097 | -9999 | 0 | -0.44 | 9 | 9 |
PLK4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of centriole replication | 0.005 | 0.07 | -9999 | 0 | -0.3 | 9 | 9 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PDGFRB | -0.017 | 0.13 | -9999 | 0 | -0.61 | 9 | 9 |
alphaV beta3 Integrin | -0.005 | 0.097 | -9999 | 0 | -0.41 | 10 | 10 |
PTK2 | -0.034 | 0.1 | -9999 | 0 | -0.4 | 12 | 12 |
positive regulation of JNK cascade | -0.02 | 0.071 | -9999 | 0 | -0.3 | 12 | 12 |
CDC42/GDP | 0.018 | 0.11 | -9999 | 0 | -0.39 | 12 | 12 |
Rac1/GDP | 0.019 | 0.11 | -9999 | 0 | -0.39 | 12 | 12 |
RAP1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42/GTP | -0.024 | 0.087 | -9999 | 0 | -0.36 | 12 | 12 |
nectin-3/I-afadin | -0.012 | 0.12 | -9999 | 0 | -0.47 | 12 | 12 |
RAPGEF1 | 0.015 | 0.12 | -9999 | 0 | -0.44 | 12 | 12 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CRK | 0.008 | 0.13 | -9999 | 0 | -0.5 | 12 | 12 |
PDGFB-D/PDGFRB | -0.017 | 0.13 | -9999 | 0 | -0.61 | 9 | 9 |
TLN1 | 0.009 | 0.066 | -9999 | 0 | -0.36 | 2 | 2 |
Rap1/GTP | -0.021 | 0.075 | -9999 | 0 | -0.31 | 12 | 12 |
IQGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rap1/GTP/I-afadin | 0.019 | 0.039 | -9999 | 0 | -0.36 | 2 | 2 |
nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin | -0.012 | 0.12 | -9999 | 0 | -0.47 | 12 | 12 |
PVR | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Necl-5(dimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | 0.012 | 0.13 | -9999 | 0 | -0.48 | 12 | 12 |
MLLT4 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | -0.003 | 0.11 | -9999 | 0 | -0.33 | 20 | 20 |
nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
positive regulation of lamellipodium assembly | -0.029 | 0.086 | -9999 | 0 | -0.29 | 18 | 18 |
PVRL1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PVRL3 | -0.022 | 0.14 | -9999 | 0 | -0.64 | 10 | 10 |
PVRL2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDH1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CLDN1 | -0.019 | 0.14 | -9999 | 0 | -0.59 | 10 | 10 |
JAM-A/CLDN1 | -0.012 | 0.12 | -9999 | 0 | -0.35 | 20 | 20 |
SRC | -0.038 | 0.14 | -9999 | 0 | -0.56 | 12 | 12 |
ITGB3 | -0.018 | 0.13 | -9999 | 0 | -0.57 | 10 | 10 |
nectin-1(dimer)/I-afadin/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
FARP2 | 0.012 | 0.13 | -9999 | 0 | -0.47 | 12 | 12 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTNNA1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) | -0.002 | 0.1 | -9999 | 0 | -0.39 | 12 | 12 |
nectin-1/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
nectin-2/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
RAC1/GTP/IQGAP1/filamentous actin | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin | -0.002 | 0.1 | -9999 | 0 | -0.39 | 12 | 12 |
CDC42/GTP/IQGAP1/filamentous actin | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
F11R | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of filopodium formation | -0.02 | 0.071 | -9999 | 0 | -0.3 | 12 | 12 |
alphaV/beta3 Integrin/Talin | 0.007 | 0.1 | -9999 | 0 | -0.64 | 2 | 2 |
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
nectin-2(dimer)/I-afadin/I-afadin | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
PIP5K1C | 0.003 | 0.071 | -9999 | 0 | -0.39 | 2 | 2 |
VAV2 | -0.004 | 0.16 | -9999 | 0 | -0.48 | 18 | 18 |
RAP1/GDP | -0.026 | 0.088 | -9999 | 0 | -0.36 | 12 | 12 |
ITGAV | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin | -0.002 | 0.1 | -9999 | 0 | -0.39 | 12 | 12 |
nectin-3(dimer)/I-afadin/I-afadin | -0.012 | 0.12 | -9999 | 0 | -0.47 | 12 | 12 |
Rac1/GTP | -0.034 | 0.1 | -9999 | 0 | -0.37 | 14 | 14 |
PTPRM | -0.006 | 0.078 | -9999 | 0 | -0.26 | 14 | 14 |
E-cadherin/beta catenin/alpha catenin | -0.005 | 0.038 | -9999 | 0 | -10000 | 0 | 0 |
adherens junction assembly | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PTK2 | -0.009 | 0.13 | -9999 | 0 | -0.48 | 12 | 12 |
CRKL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DOCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGA4 | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
alpha4/beta7 Integrin/MAdCAM1 | -0.089 | 0.18 | -9999 | 0 | -0.42 | 33 | 33 |
EPO | 0.007 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
alpha4/beta7 Integrin | -0.027 | 0.15 | -9999 | 0 | -0.48 | 17 | 17 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CRK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin | -0.003 | 0.095 | -9999 | 0 | -0.43 | 9 | 9 |
EPO/EPOR (dimer) | 0.012 | 0.035 | -9999 | 0 | -0.47 | 1 | 1 |
lamellipodium assembly | 0.003 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JAK2 | 0.011 | 0.068 | -9999 | 0 | -0.29 | 8 | 8 |
PXN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MADCAM1 | -0.14 | 0.24 | -9999 | 0 | -0.49 | 57 | 57 |
cell adhesion | -0.089 | 0.18 | -9999 | 0 | -0.42 | 33 | 33 |
CRKL/CBL | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | -0.013 | 0.14 | -9999 | 0 | -0.5 | 12 | 12 |
ITGB7 | -0.023 | 0.14 | -9999 | 0 | -0.54 | 12 | 12 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin/VCAM1 | -0.022 | 0.15 | -9999 | 0 | -0.55 | 12 | 12 |
p130Cas/Crk/Dock1 | 0.009 | 0.12 | -9999 | 0 | -0.55 | 6 | 6 |
VCAM1 | -0.036 | 0.16 | -9999 | 0 | -0.53 | 17 | 17 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin/Paxillin/GIT1 | 0.014 | 0.075 | -9999 | 0 | -0.35 | 7 | 7 |
BCAR1 | -0.005 | 0.13 | -9999 | 0 | -0.46 | 12 | 12 |
EPOR | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CBL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GIT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GTP | 0.003 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
mol:S1P | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
telencephalon oligodendrocyte cell migration | 0.051 | 0.11 | 0.55 | 4 | -10000 | 0 | 4 |
GNAI2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
S1P/S1P5/G12 | 0.008 | 0.06 | -10000 | 0 | -0.4 | 4 | 4 |
mol:GDP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAO1 | -0.099 | 0.22 | -10000 | 0 | -0.53 | 39 | 39 |
RhoA/GTP | -0.027 | 0.12 | -10000 | 0 | -0.57 | 4 | 4 |
negative regulation of cAMP metabolic process | -0.035 | 0.14 | -10000 | 0 | -0.32 | 24 | 24 |
GNAZ | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
GNAI3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNA12 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
S1PR5 | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
S1P/S1P5/Gi | -0.036 | 0.14 | -10000 | 0 | -0.33 | 24 | 24 |
RhoA/GDP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -10000 | 0 | -0.64 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TGFB1 | -0.023 | 0.18 | -10000 | 0 | -1.2 | 4 | 4 |
VDR | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
FAM120B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RXRs/LXRs/DNA/9cRA | 0.032 | 0.08 | -10000 | 0 | -0.44 | 2 | 2 |
RXRs/LXRs/DNA/Oxysterols | 0.032 | 0.12 | -10000 | 0 | -0.48 | 8 | 8 |
MED1 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
mol:9cRA | 0.003 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
RARs/THRs/DNA/Src-1 | -0.022 | 0.12 | -10000 | 0 | -0.55 | 1 | 1 |
RXRs/NUR77 | 0.012 | 0.089 | -10000 | 0 | -0.38 | 4 | 4 |
RXRs/PPAR | 0.021 | 0.058 | -10000 | 0 | -10000 | 0 | 0 |
NCOR2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
VDR/VDR/Vit D3 | 0.006 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
RARs/VDR/DNA/Vit D3 | 0.013 | 0.069 | -10000 | 0 | -0.33 | 6 | 6 |
RARA | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
NCOA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VDR/VDR/DNA | 0.009 | 0.046 | -10000 | 0 | -0.63 | 1 | 1 |
RARs/RARs/DNA/9cRA | 0.01 | 0.066 | -10000 | 0 | -0.34 | 5 | 5 |
RARG | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
RPS6KB1 | -0.003 | 0.064 | -10000 | 0 | -0.41 | 4 | 4 |
RARs/THRs/DNA/SMRT | -0.024 | 0.12 | -10000 | 0 | -0.28 | 31 | 31 |
THRA | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
mol:Bile acids | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VDR/Vit D3/DNA | 0.006 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
RXRs/PPAR/9cRA/PGJ2/DNA | 0.022 | 0.072 | 0.29 | 2 | -0.28 | 2 | 4 |
NR1H4 | -0.14 | 0.24 | -10000 | 0 | -0.51 | 57 | 57 |
RXRs/LXRs/DNA | 0.038 | 0.073 | -10000 | 0 | -10000 | 0 | 0 |
NR1H2 | 0.016 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
NR1H3 | 0.016 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
RXRs/VDR/DNA/Vit D3 | 0.022 | 0.062 | -10000 | 0 | -0.33 | 1 | 1 |
NR4A1 | -0.013 | 0.11 | -10000 | 0 | -0.46 | 10 | 10 |
mol:ATRA | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RXRs/FXR/9cRA/MED1 | -0.038 | 0.11 | -10000 | 0 | -0.28 | 25 | 25 |
RXRG | -0.013 | 0.1 | -10000 | 0 | -0.42 | 11 | 11 |
RXR alpha/CCPG | 0.021 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
RXRA | 0.016 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
RXRB | 0.016 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
THRB | -0.085 | 0.23 | -10000 | 0 | -0.6 | 30 | 30 |
PPARG | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
PPARD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TNF | 0.01 | 0.23 | -10000 | 0 | -1.2 | 7 | 7 |
mol:Oxysterols | 0.003 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
cholesterol transport | 0.032 | 0.12 | -10000 | 0 | -0.47 | 8 | 8 |
PPARA | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
mol:Vit D3 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RARB | -0.008 | 0.11 | -10000 | 0 | -0.54 | 7 | 7 |
RXRs/NUR77/BCL2 | 0.005 | 0.068 | -10000 | 0 | -0.28 | 5 | 5 |
SREBF1 | 0.038 | 0.11 | -10000 | 0 | -0.73 | 2 | 2 |
RXRs/RXRs/DNA/9cRA | 0.022 | 0.072 | 0.28 | 2 | -0.28 | 2 | 4 |
ABCA1 | 0.027 | 0.18 | -10000 | 0 | -1.2 | 3 | 3 |
RARs/THRs | -0.034 | 0.14 | -10000 | 0 | -0.34 | 31 | 31 |
RXRs/FXR | -0.064 | 0.15 | -10000 | 0 | -0.36 | 27 | 27 |
BCL2 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CTTN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Syndecan-3/Src/Cortactin | 0 | 0.11 | -9999 | 0 | -0.33 | 15 | 15 |
Syndecan-3/Neurocan | -0.012 | 0.07 | -9999 | 0 | -0.62 | 2 | 2 |
POMC | -0.05 | 0.18 | -9999 | 0 | -0.52 | 22 | 22 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
Syndecan-3/EGFR | -0.008 | 0.066 | -9999 | 0 | -0.62 | 2 | 2 |
AGRP | -0.005 | 0.06 | -9999 | 0 | -0.42 | 4 | 4 |
NCSTN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PSENEN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RP11-540L11.1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
APH1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
APH1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCAN | -0.006 | 0.074 | -9999 | 0 | -0.42 | 6 | 6 |
long-term memory | 0.02 | 0.068 | -9999 | 0 | -0.49 | 3 | 3 |
Syndecan-3/IL8 | -0.063 | 0.13 | -9999 | 0 | -0.36 | 22 | 22 |
PSEN1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Src/Cortactin | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FYN | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
limb bud formation | -0.007 | 0.065 | -9999 | 0 | -0.64 | 2 | 2 |
MC4R | -0.007 | 0.067 | -9999 | 0 | -0.42 | 5 | 5 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTN | -0.045 | 0.18 | -9999 | 0 | -0.56 | 19 | 19 |
FGFR/FGF/Syndecan-3 | -0.007 | 0.066 | -9999 | 0 | -0.65 | 2 | 2 |
neuron projection morphogenesis | -0.015 | 0.1 | -9999 | 0 | -0.48 | 3 | 3 |
Syndecan-3/AgRP | -0.01 | 0.068 | -9999 | 0 | -0.62 | 2 | 2 |
Syndecan-3/AgRP/MC4R | -0.011 | 0.073 | -9999 | 0 | -0.61 | 2 | 2 |
Fyn/Cortactin | 0.014 | 0.041 | -9999 | 0 | -0.38 | 2 | 2 |
SDC3 | -0.007 | 0.067 | -9999 | 0 | -0.66 | 2 | 2 |
GO:0007205 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of leukocyte migration | -0.062 | 0.13 | -9999 | 0 | -0.36 | 22 | 22 |
IL8 | -0.11 | 0.23 | -9999 | 0 | -0.52 | 43 | 43 |
Syndecan-3/Fyn/Cortactin | 0.02 | 0.069 | -9999 | 0 | -0.5 | 3 | 3 |
Syndecan-3/CASK | -0.007 | 0.064 | -9999 | 0 | -0.63 | 2 | 2 |
alpha-MSH/MC4R | -0.041 | 0.14 | -9999 | 0 | -0.39 | 25 | 25 |
Gamma Secretase | 0.036 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
S1P1/Sphingosine-1-phosphate | -0.032 | 0.16 | -9999 | 0 | -0.46 | 19 | 19 |
PDGFB-D/PDGFRB/SLAP | -0.043 | 0.17 | -9999 | 0 | -0.46 | 24 | 24 |
PDGFB-D/PDGFRB/APS/CBL | 0 | 0.1 | -9999 | 0 | -0.44 | 9 | 9 |
AKT1 | 0.033 | 0.074 | -9999 | 0 | -0.42 | 1 | 1 |
mol:PI-4-5-P2 | 0 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mol:Sphingosine-1-phosphate | -0.035 | 0.17 | -9999 | 0 | -0.5 | 18 | 18 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FGR | -0.06 | 0.21 | -9999 | 0 | -0.67 | 16 | 16 |
mol:Ca2+ | -0.019 | 0.15 | -9999 | 0 | -0.68 | 8 | 8 |
MYC | -0.013 | 0.16 | -9999 | 0 | -0.64 | 8 | 8 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HRAS/GDP | 0.017 | 0.072 | -9999 | 0 | -0.32 | 8 | 8 |
LRP1/PDGFRB/PDGFB | -0.005 | 0.12 | -9999 | 0 | -0.47 | 10 | 10 |
GRB10 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GO:0007205 | -0.02 | 0.15 | -9999 | 0 | -0.7 | 8 | 8 |
PTEN | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRB7 | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
PDGFB-D/PDGFRB/SHP2 | -0.005 | 0.099 | -9999 | 0 | -0.45 | 9 | 9 |
PDGFB-D/PDGFRB/GRB10 | -0.007 | 0.1 | -9999 | 0 | -0.45 | 10 | 10 |
cell cycle arrest | -0.043 | 0.17 | -9999 | 0 | -0.46 | 24 | 24 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A | 0.038 | 0.067 | -9999 | 0 | -0.37 | 1 | 1 |
GAB1 | -0.033 | 0.17 | -9999 | 0 | -0.67 | 9 | 9 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DNM2 | -0.028 | 0.16 | -9999 | 0 | -0.59 | 10 | 10 |
PDGFB-D/PDGFRB | 0.006 | 0.089 | -9999 | 0 | -0.41 | 8 | 8 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB/LMW-PTP | -0.005 | 0.099 | -9999 | 0 | -0.45 | 9 | 9 |
S1P1/Sphingosine-1-phosphate/PDGFB-D/PDGFRB | -0.058 | 0.16 | -9999 | 0 | -0.48 | 19 | 19 |
positive regulation of MAPKKK cascade | -0.005 | 0.099 | -9999 | 0 | -0.45 | 9 | 9 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:IP3 | -0.02 | 0.16 | -9999 | 0 | -0.71 | 8 | 8 |
E5 | -0.001 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
CSK | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB/GRB7 | -0.008 | 0.11 | -9999 | 0 | -0.46 | 10 | 10 |
SHB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BLK | -0.093 | 0.21 | -9999 | 0 | -0.59 | 24 | 24 |
PTPN2 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB/SNX15 | -0.005 | 0.099 | -9999 | 0 | -0.45 | 9 | 9 |
BCAR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VAV2 | -0.039 | 0.19 | -9999 | 0 | -0.72 | 10 | 10 |
CBL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB-D/PDGFRB/DEP1 | -0.007 | 0.11 | -9999 | 0 | -0.49 | 9 | 9 |
LCK | -0.049 | 0.16 | -9999 | 0 | -0.56 | 13 | 13 |
PDGFRB | -0.018 | 0.13 | -9999 | 0 | -0.62 | 9 | 9 |
ACP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HCK | -0.062 | 0.22 | -9999 | 0 | -0.71 | 17 | 17 |
ABL1 | -0.031 | 0.16 | -9999 | 0 | -0.63 | 9 | 9 |
PDGFB-D/PDGFRB/CBL | -0.037 | 0.18 | -9999 | 0 | -0.73 | 9 | 9 |
PTPN1 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
SNX15 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT1 | 0.005 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
cell proliferation | -0.01 | 0.14 | -9999 | 0 | -0.57 | 8 | 8 |
SLA | -0.041 | 0.17 | -9999 | 0 | -0.58 | 17 | 17 |
actin cytoskeleton reorganization | 0.027 | 0.071 | -9999 | 0 | -0.32 | 2 | 2 |
SRC | -0.018 | 0.088 | -9999 | 0 | -0.42 | 8 | 8 |
PI3K | -0.016 | 0.068 | -9999 | 0 | -0.46 | 1 | 1 |
PDGFB-D/PDGFRB/GRB7/SHC | 0.002 | 0.093 | -9999 | 0 | -0.42 | 8 | 8 |
SH2B2 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
PLCgamma1/SPHK1 | -0.037 | 0.18 | -9999 | 0 | -0.52 | 18 | 18 |
LYN | -0.017 | 0.087 | -9999 | 0 | -0.42 | 8 | 8 |
LRP1 | 0 | 0.086 | -9999 | 0 | -0.58 | 4 | 4 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT5B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT5A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCK1-2/p130 Cas | 0 | 0.07 | -9999 | 0 | -0.32 | 8 | 8 |
SPHK1 | -0.049 | 0.18 | -9999 | 0 | -0.54 | 21 | 21 |
EDG1 | -0.001 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
mol:DAG | -0.02 | 0.16 | -9999 | 0 | -0.71 | 8 | 8 |
PLCG1 | -0.021 | 0.16 | -9999 | 0 | -0.74 | 8 | 8 |
NHERF/PDGFRB | 0.003 | 0.092 | -9999 | 0 | -0.42 | 8 | 8 |
YES1 | -0.018 | 0.088 | -9999 | 0 | -0.42 | 8 | 8 |
cell migration | 0.003 | 0.091 | -9999 | 0 | -0.42 | 8 | 8 |
SHC/Grb2/SOS1 | 0 | 0.07 | -9999 | 0 | -0.33 | 1 | 1 |
SLC9A3R2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SLC9A3R1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
NHERF1-2/PDGFRB/PTEN | 0.007 | 0.092 | -9999 | 0 | -0.37 | 10 | 10 |
FYN | -0.02 | 0.096 | -9999 | 0 | -0.44 | 9 | 9 |
DOK1 | 0.011 | 0.079 | -9999 | 0 | -0.36 | 8 | 8 |
HRAS/GTP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDGFB | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
RAC1 | -0.026 | 0.18 | -9999 | 0 | -0.63 | 11 | 11 |
PRKCD | 0.011 | 0.08 | -9999 | 0 | -0.36 | 8 | 8 |
FER | 0.01 | 0.082 | -9999 | 0 | -0.36 | 8 | 8 |
MAPKKK cascade | -0.014 | 0.063 | -9999 | 0 | -10000 | 0 | 0 |
RASA1 | 0.011 | 0.08 | -9999 | 0 | -0.36 | 8 | 8 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
p62DOK/Csk | 0.019 | 0.073 | -9999 | 0 | -0.32 | 8 | 8 |
PDGFB-D/PDGFRB/SHB | -0.005 | 0.099 | -9999 | 0 | -0.45 | 9 | 9 |
chemotaxis | -0.029 | 0.15 | -9999 | 0 | -0.6 | 9 | 9 |
STAT1-3-5/STAT1-3-5 | -0.015 | 0.064 | -9999 | 0 | -10000 | 0 | 0 |
Bovine Papilomavirus E5/PDGFRB | -0.013 | 0.1 | -9999 | 0 | -0.46 | 9 | 9 |
PTPRJ | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NFATC3 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
PLK1 | 0.053 | 0.043 | -9999 | 0 | -10000 | 0 | 0 |
BIRC5 | 0.053 | 0.043 | -9999 | 0 | -10000 | 0 | 0 |
HSPA1B | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
MAP2K1 | 0.037 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
BRCA2 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
FOXM1 | 0.11 | 0.35 | -9999 | 0 | -1 | 7 | 7 |
XRCC1 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
FOXM1B/p19 | -0.11 | 0.26 | -9999 | 0 | -1 | 9 | 9 |
Cyclin D1/CDK4 | 0.11 | 0.3 | -9999 | 0 | -0.81 | 7 | 7 |
CDC2 | 0.12 | 0.33 | -9999 | 0 | -0.93 | 7 | 7 |
TGFA | 0.11 | 0.31 | -9999 | 0 | -0.97 | 2 | 2 |
SKP2 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
CCNE1 | 0.015 | 0.033 | -9999 | 0 | -0.43 | 1 | 1 |
CKS1B | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
RB1 | -0.037 | 0.087 | -9999 | 0 | -10000 | 0 | 0 |
FOXM1C/SP1 | 0.11 | 0.33 | -9999 | 0 | -0.95 | 8 | 8 |
AURKB | 0.053 | 0.043 | -9999 | 0 | -10000 | 0 | 0 |
CENPF | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
CDK4 | 0.022 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
MYC | 0.11 | 0.31 | -9999 | 0 | -0.82 | 8 | 8 |
CHEK2 | 0.037 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
ONECUT1 | 0.11 | 0.31 | -9999 | 0 | -0.85 | 8 | 8 |
CDKN2A | -0.064 | 0.18 | -9999 | 0 | -0.5 | 26 | 26 |
LAMA4 | 0.11 | 0.35 | -9999 | 0 | -1.1 | 8 | 8 |
FOXM1B/HNF6 | 0.11 | 0.33 | -9999 | 0 | -0.96 | 8 | 8 |
FOS | 0.082 | 0.39 | -9999 | 0 | -1 | 14 | 14 |
SP1 | 0.013 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
CDC25B | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
response to radiation | 0.022 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
CENPB | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
CENPA | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
NEK2 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
HIST1H2BA | 0.11 | 0.32 | -9999 | 0 | -0.89 | 7 | 7 |
CCNA2 | 0.017 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
EP300 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
CCNB1/CDK1 | 0.11 | 0.34 | -9999 | 0 | -0.99 | 7 | 7 |
CCNB2 | 0.12 | 0.32 | -9999 | 0 | -0.88 | 7 | 7 |
CCNB1 | 0.12 | 0.33 | -9999 | 0 | -0.92 | 7 | 7 |
ETV5 | 0.11 | 0.34 | -9999 | 0 | -0.96 | 9 | 9 |
ESR1 | 0.058 | 0.45 | -9999 | 0 | -1.2 | 15 | 15 |
CCND1 | 0.12 | 0.31 | -9999 | 0 | -0.83 | 7 | 7 |
GSK3A | 0.034 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
Cyclin A-E1/CDK1-2 | 0.046 | 0.04 | -9999 | 0 | -10000 | 0 | 0 |
CDK2 | 0.017 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition of mitotic cell cycle | 0.025 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
FOXM1B/Cbp/p300 | -0.088 | 0.21 | -9999 | 0 | -0.93 | 7 | 7 |
GAS1 | -0.013 | 0.54 | -9999 | 0 | -1.1 | 31 | 31 |
MMP2 | 0.07 | 0.44 | -9999 | 0 | -1.3 | 14 | 14 |
RB1/FOXM1C | 0.12 | 0.31 | -9999 | 0 | -0.86 | 7 | 7 |
CREBBP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
EP300 | 0.008 | 0.046 | -10000 | 0 | -0.62 | 1 | 1 |
HSPA8 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/ER alpha | -0.053 | 0.14 | 0.22 | 1 | -0.4 | 21 | 22 |
AKT1 | 0.01 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
GSC | -0.021 | 0.16 | -10000 | 0 | -1.4 | 2 | 2 |
NKX2-5 | -0.012 | 0.075 | -10000 | 0 | -0.42 | 6 | 6 |
muscle cell differentiation | 0.04 | 0.1 | 0.52 | 5 | -10000 | 0 | 5 |
SMAD2-3/SMAD4/SP1 | 0.019 | 0.12 | -10000 | 0 | -0.41 | 5 | 5 |
SMAD4 | 0 | 0.065 | -10000 | 0 | -0.6 | 1 | 1 |
CBFB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SAP18 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
Cbp/p300/MSG1 | -0.032 | 0.12 | -10000 | 0 | -0.39 | 9 | 9 |
SMAD3/SMAD4/VDR | -0.01 | 0.061 | -10000 | 0 | -0.37 | 1 | 1 |
MYC | 0.004 | 0.081 | -10000 | 0 | -0.62 | 3 | 3 |
CDKN2B | -0.05 | 0.32 | -10000 | 0 | -1.4 | 10 | 10 |
AP1 | 0.011 | 0.11 | -10000 | 0 | -0.45 | 6 | 6 |
SMAD2/SMAD2/SMAD4/SnoN/SIN3/HDAC complex/NCoR1 | 0.045 | 0.04 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2-3/SMAD4/FOXO1-3a-4/FOXG1 | 0.006 | 0.098 | -10000 | 0 | -0.33 | 11 | 11 |
SP3 | 0.014 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CREB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXH1 | -0.047 | 0.16 | -10000 | 0 | -0.5 | 21 | 21 |
SMAD3/SMAD4/GR | -0.028 | 0.1 | -10000 | 0 | -0.43 | 8 | 8 |
GATA3 | -0.04 | 0.16 | -10000 | 0 | -0.59 | 13 | 13 |
SKI/SIN3/HDAC complex/NCoR1 | 0.041 | 0.019 | -10000 | 0 | -10000 | 0 | 0 |
MEF2C/TIF2 | -0.019 | 0.14 | -10000 | 0 | -0.54 | 7 | 7 |
endothelial cell migration | 0.077 | 0.3 | 1.3 | 10 | -10000 | 0 | 10 |
MAX | 0.015 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
RBBP7 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
RBBP4 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
RUNX2 | -0.003 | 0.091 | -10000 | 0 | -0.55 | 5 | 5 |
RUNX3 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
RUNX1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CTBP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NR3C1 | -0.01 | 0.11 | -10000 | 0 | -0.49 | 9 | 9 |
VDR | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
CDKN1A | 0.016 | 0.16 | -10000 | 0 | -1 | 3 | 3 |
KAT2B | 0.008 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
SMAD2/SMAD2/SMAD4/FOXH1 | -0.021 | 0.13 | -10000 | 0 | -0.4 | 12 | 12 |
DCP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SKI | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
SERPINE1 | -0.078 | 0.31 | -10000 | 0 | -1.3 | 10 | 10 |
SMAD3/SMAD4/ATF2 | -0.017 | 0.066 | -10000 | 0 | -0.37 | 4 | 4 |
SMAD3/SMAD4/ATF3 | -0.025 | 0.08 | -10000 | 0 | -0.36 | 7 | 7 |
SAP30 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
Cbp/p300/PIAS3 | 0.011 | 0.036 | -10000 | 0 | -0.36 | 1 | 1 |
JUN | 0.011 | 0.11 | -10000 | 0 | -0.44 | 6 | 6 |
SMAD3/SMAD4/IRF7 | -0.017 | 0.066 | -10000 | 0 | -0.37 | 4 | 4 |
TFE3 | 0.014 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
COL1A2 | -0.068 | 0.28 | -10000 | 0 | -1 | 13 | 13 |
mesenchymal cell differentiation | 0.027 | 0.089 | 0.39 | 8 | -10000 | 0 | 8 |
DLX1 | -0.057 | 0.16 | -10000 | 0 | -0.43 | 29 | 29 |
TCF3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOS | -0.024 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
SMAD3/SMAD4/Max | -0.013 | 0.069 | -10000 | 0 | -0.38 | 4 | 4 |
Cbp/p300/SNIP1 | 0.02 | 0.03 | -10000 | 0 | -0.37 | 1 | 1 |
ZBTB17 | 0.014 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
LAMC1 | 0.023 | 0.071 | -10000 | 0 | -0.35 | 2 | 2 |
TGIF2/HDAC complex/SMAD3/SMAD4 | -0.021 | 0.079 | -10000 | 0 | -0.4 | 6 | 6 |
IRF7 | 0.013 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
ESR1 | -0.06 | 0.19 | -10000 | 0 | -0.51 | 27 | 27 |
HNF4A | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
MEF2C | -0.023 | 0.15 | -10000 | 0 | -0.53 | 9 | 9 |
SMAD2-3/SMAD4 | -0.008 | 0.091 | -10000 | 0 | -0.46 | 4 | 4 |
Cbp/p300/Src-1 | 0.021 | 0.031 | -10000 | 0 | -0.37 | 1 | 1 |
IGHV3OR16-13 | -0.004 | 0.018 | -10000 | 0 | -10000 | 0 | 0 |
TGIF2/HDAC complex | 0.005 | 0.066 | -10000 | 0 | -0.63 | 2 | 2 |
CREBBP | 0.011 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
SKIL | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
HDAC1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
HDAC2 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
SNIP1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
GCN5L2 | -0.001 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/TFE3 | 0.019 | 0.083 | -10000 | 0 | -0.37 | 4 | 4 |
MSG1/HSC70 | -0.045 | 0.14 | -10000 | 0 | -0.32 | 35 | 35 |
SMAD2 | 0.005 | 0.053 | -10000 | 0 | -0.63 | 1 | 1 |
SMAD3 | -0.003 | 0.093 | -10000 | 0 | -0.65 | 3 | 3 |
SMAD3/E2F4-5/DP1/p107/SMAD4 | 0.024 | 0.061 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2/SMAD2/SMAD4 | 0.004 | 0.048 | -10000 | 0 | -0.36 | 2 | 2 |
NCOR1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
NCOA2 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
NCOA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MYOD/E2A | 0.009 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2-3/SMAD4/SP1/MIZ-1 | 0.027 | 0.11 | -10000 | 0 | -0.43 | 3 | 3 |
IFNB1 | 0.015 | 0.068 | -10000 | 0 | -0.36 | 2 | 2 |
SMAD3/SMAD4/MEF2C | -0.02 | 0.16 | -10000 | 0 | -0.59 | 7 | 7 |
CITED1 | -0.075 | 0.19 | -10000 | 0 | -0.47 | 35 | 35 |
SMAD2-3/SMAD4/ARC105 | 0.018 | 0.087 | -10000 | 0 | -0.45 | 3 | 3 |
RBL1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2-3/SMAD4/FOXO1-3a-4/CEBPB | 0.013 | 0.13 | -10000 | 0 | -0.49 | 11 | 11 |
RUNX1-3/PEBPB2 | 0.014 | 0.06 | -10000 | 0 | -0.39 | 3 | 3 |
SMAD7 | 0.027 | 0.12 | -10000 | 0 | -0.53 | 3 | 3 |
MYC/MIZ-1 | 0.006 | 0.067 | -10000 | 0 | -0.44 | 3 | 3 |
SMAD3/SMAD4 | -0.021 | 0.12 | 0.39 | 1 | -0.49 | 7 | 8 |
IL10 | -0.059 | 0.24 | -10000 | 0 | -0.64 | 24 | 24 |
PIASy/HDAC complex | 0.013 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
PIAS3 | 0.011 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
CDK2 | 0.011 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
IL5 | -0.028 | 0.16 | -10000 | 0 | -0.52 | 9 | 9 |
CDK4 | 0.011 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
PIAS4 | 0.013 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
ATF3 | 0 | 0.076 | -10000 | 0 | -0.46 | 5 | 5 |
SMAD3/SMAD4/SP1 | 0.008 | 0.11 | -10000 | 0 | -0.36 | 5 | 5 |
FOXG1 | -0.051 | 0.14 | -10000 | 0 | -0.42 | 24 | 24 |
FOXO3 | 0.018 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
FOXO1 | 0.018 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
FOXO4 | 0.018 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
heart looping | -0.023 | 0.15 | -10000 | 0 | -0.52 | 9 | 9 |
CEBPB | 0.011 | 0.009 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/DLX1 | -0.055 | 0.11 | -10000 | 0 | -0.37 | 11 | 11 |
MYOD1 | 0 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/HNF4 | -0.024 | 0.088 | -10000 | 0 | -0.42 | 7 | 7 |
SMAD3/SMAD4/GATA3 | -0.065 | 0.16 | -10000 | 0 | -0.46 | 18 | 18 |
SnoN/SIN3/HDAC complex/NCoR1 | 0.009 | 0.046 | -10000 | 0 | -0.63 | 1 | 1 |
SMAD3/SMAD4/RUNX1-3/PEBPB2 | 0.017 | 0.097 | -10000 | 0 | -0.57 | 3 | 3 |
SMAD3/SMAD4/SP1-3 | 0.024 | 0.097 | -10000 | 0 | -0.34 | 2 | 2 |
MED15 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SP1 | 0.006 | 0.045 | -10000 | 0 | -10000 | 0 | 0 |
SIN3B | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
SIN3A | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2/SMAD2/SMAD4/FOXH1/NKX2-5 | -0.023 | 0.13 | -10000 | 0 | -0.36 | 15 | 15 |
ITGB5 | 0.027 | 0.087 | -10000 | 0 | -10000 | 0 | 0 |
TGIF/SIN3/HDAC complex/CtBP | 0.042 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/AR | -0.082 | 0.14 | -10000 | 0 | -0.4 | 25 | 25 |
AR | -0.095 | 0.21 | -10000 | 0 | -0.5 | 40 | 40 |
negative regulation of cell growth | 0.025 | 0.077 | -10000 | 0 | -0.36 | 3 | 3 |
SMAD3/SMAD4/MYOD | -0.018 | 0.069 | -10000 | 0 | -0.38 | 4 | 4 |
E2F5 | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
E2F4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SMAD2/SMAD2/SMAD4/FOXH1/SMIF | -0.003 | 0.11 | -10000 | 0 | -0.35 | 10 | 10 |
SMAD2-3/SMAD4/FOXO1-3a-4 | 0.018 | 0.1 | -10000 | 0 | -0.34 | 11 | 11 |
TFDP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4/AP1 | 0.012 | 0.11 | -10000 | 0 | -0.45 | 6 | 6 |
SMAD3/SMAD4/RUNX2 | -0.027 | 0.09 | -10000 | 0 | -0.4 | 8 | 8 |
TGIF2 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
TGIF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ATF2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
ErbB4/ErbB4/HBEGF/HBEGF | 0.025 | 0.036 | -10000 | 0 | -10000 | 0 | 0 |
epithelial cell differentiation | -0.045 | 0.091 | -10000 | 0 | -0.4 | 3 | 3 |
ITCH | 0.013 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
WWP1 | 0.03 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
FYN | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
EGFR | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
PRL | -0.024 | 0.11 | -10000 | 0 | -0.42 | 14 | 14 |
neuron projection morphogenesis | 0.01 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
PTPRZ1 | -0.11 | 0.22 | -10000 | 0 | -0.49 | 45 | 45 |
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/GRB2/SHC | -0.004 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4 CYT2/ErbB4 CYT2/neuregulin 1 beta/neuregulin 1 beta | -0.021 | 0.12 | -10000 | 0 | -0.35 | 19 | 19 |
ADAM17 | 0.013 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/ErbB4 | 0.03 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/ErbB4/neuregulin 3/neuregulin 3 | 0.016 | 0.033 | -10000 | 0 | -10000 | 0 | 0 |
NCOR1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta/Fyn | -0.017 | 0.12 | -10000 | 0 | -10000 | 0 | 0 |
GRIN2B | -0.038 | 0.15 | -10000 | 0 | -0.59 | 5 | 5 |
ErbB4/ErbB2/betacellulin | 0.029 | 0.05 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 | 0.005 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
HBEGF | 0.003 | 0.061 | -10000 | 0 | -0.42 | 4 | 4 |
PRLR | -0.052 | 0.19 | -10000 | 0 | -0.64 | 19 | 19 |
E4ICDs/ETO2 | -0.036 | 0.13 | -10000 | 0 | -0.37 | 17 | 17 |
axon guidance | 0.031 | 0.076 | -10000 | 0 | -10000 | 0 | 0 |
NEDD4 | 0.013 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
Prolactin receptor/Prolactin receptor/Prolactin | -0.055 | 0.17 | -10000 | 0 | -0.42 | 30 | 30 |
CBFA2T3 | -0.1 | 0.22 | -10000 | 0 | -0.5 | 42 | 42 |
ErbB4/ErbB2/HBEGF | 0.03 | 0.038 | -10000 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.003 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
STAT1 (dimer) | 0.027 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.003 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
JAK2 | 0.005 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
ErbB4/ErbB2/neuregulin 1 beta | -0.016 | 0.12 | -10000 | 0 | -0.52 | 1 | 1 |
NRG1 | -0.049 | 0.16 | -10000 | 0 | -0.4 | 32 | 32 |
NRG3 | 0.001 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
NRG2 | -0.016 | 0.099 | -10000 | 0 | -0.42 | 11 | 11 |
NRG4 | -0.017 | 0.1 | -10000 | 0 | -0.42 | 12 | 12 |
heart development | 0.031 | 0.076 | -10000 | 0 | -10000 | 0 | 0 |
neural crest cell migration | -0.016 | 0.12 | -10000 | 0 | -0.52 | 1 | 1 |
ERBB2 | 0.018 | 0.031 | -10000 | 0 | -0.29 | 2 | 2 |
WWOX/E4ICDs | 0.026 | 0.042 | -10000 | 0 | -0.37 | 2 | 2 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/EGFR/neuregulin 4 | 0.012 | 0.059 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | 0.031 | 0.045 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/ErbB4/neuregulin 2 beta/neuregulin 2 beta | 0.008 | 0.06 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/ErbB2/epiregulin | -0.078 | 0.16 | -10000 | 0 | -0.37 | 4 | 4 |
ErbB4/ErbB4/betacellulin/betacellulin | 0.024 | 0.051 | -10000 | 0 | -0.37 | 3 | 3 |
ErbB4/ErbB4/HBEGF/HBEGF/Prolactin receptor/Prolactin receptor/Prolactin/JAK2 | -0.039 | 0.12 | -10000 | 0 | -0.5 | 5 | 5 |
MDM2 | 0.033 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4 JM-B/ErbB4 JM-B/neuregulin 1 beta/neuregulin 1 beta | -0.031 | 0.11 | -10000 | 0 | -0.34 | 19 | 19 |
STAT5A | 0.035 | 0.071 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/EGFR/neuregulin 1 beta | -0.016 | 0.12 | -10000 | 0 | -10000 | 0 | 0 |
DLG4 | 0.003 | 0.072 | -10000 | 0 | -0.56 | 3 | 3 |
GRB2/SHC | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
E4ICDs/TAB2/NCoR1 | -0.003 | 0.025 | -10000 | 0 | -0.34 | 1 | 1 |
STAT5A (dimer) | -0.047 | 0.097 | -10000 | 0 | -0.43 | 3 | 3 |
MAP3K7IP2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STAT5B (dimer) | 0.033 | 0.068 | -10000 | 0 | -10000 | 0 | 0 |
LRIG1 | -0.005 | 0.1 | -10000 | 0 | -0.64 | 5 | 5 |
EREG | -0.19 | 0.29 | -10000 | 0 | -0.59 | 65 | 65 |
BTC | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
ErbB4/ErbB4/neuregulin 1 beta/neuregulin 1 beta | 0.03 | 0.077 | -10000 | 0 | -10000 | 0 | 0 |
ERBB4 | 0.03 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
STAT5B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YAP1 | 0.001 | 0.017 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ErbB4/ErbB2/neuregulin 4 | 0.014 | 0.057 | -10000 | 0 | -10000 | 0 | 0 |
glial cell differentiation | 0.003 | 0.025 | 0.34 | 1 | -10000 | 0 | 1 |
WWOX | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
cell proliferation | -0.003 | 0.13 | -10000 | 0 | -0.55 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 | -0.019 | 0.11 | -9999 | 0 | -0.31 | 20 | 20 |
positive regulation of NF-kappaB transcription factor activity | 0 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
CRKL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT1 (dimer)/Cbp/p300 | 0.006 | 0.12 | -9999 | 0 | -0.56 | 3 | 3 |
IFN-gammaR/JAK1/JAK1/JAK2/JAK2 | -0.013 | 0.046 | -9999 | 0 | -0.32 | 3 | 3 |
antigen processing and presentation of peptide antigen via MHC class I | -0.035 | 0.072 | -9999 | 0 | -0.29 | 5 | 5 |
CaM/Ca2+ | -0.042 | 0.093 | -9999 | 0 | -0.32 | 4 | 4 |
RAP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT1 (dimer)/SHP2 | -0.013 | 0.12 | -9999 | 0 | -0.42 | 5 | 5 |
AKT1 | 0.001 | 0.1 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K1 | -0.005 | 0.1 | -9999 | 0 | -0.31 | 4 | 4 |
MAP3K11 | -0.013 | 0.11 | -9999 | 0 | -0.33 | 4 | 4 |
IFNGR1 | 0.008 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/CAMKII | -0.057 | 0.13 | -9999 | 0 | -0.48 | 14 | 14 |
Rap1/GTP | -0.031 | 0.069 | -9999 | 0 | -10000 | 0 | 0 |
CRKL/C3G | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 /TC-PTP | -0.021 | 0.12 | -9999 | 0 | -0.33 | 20 | 20 |
CEBPB | -0.009 | 0.16 | -9999 | 0 | -0.41 | 14 | 14 |
STAT3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2/SOCS1 | -0.031 | 0.18 | -9999 | 0 | -1.2 | 3 | 3 |
STAT1 | -0.014 | 0.12 | -9999 | 0 | -0.42 | 5 | 5 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IFN-gamma (dimer) | -0.084 | 0.21 | -9999 | 0 | -0.51 | 35 | 35 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT1 (dimer)/PIAS1 | -0.006 | 0.12 | -9999 | 0 | -0.46 | 3 | 3 |
CEBPB/PTGES2/Cbp/p300 | -0.04 | 0.081 | -9999 | 0 | -0.35 | 3 | 3 |
mol:Ca2+ | -0.021 | 0.11 | -9999 | 0 | -0.31 | 20 | 20 |
MAPK3 | -0.001 | 0.11 | -9999 | 0 | -0.38 | 1 | 1 |
STAT1 (dimer) | -0.046 | 0.097 | -9999 | 0 | -0.45 | 3 | 3 |
MAPK1 | -0.001 | 0.11 | -9999 | 0 | -10000 | 0 | 0 |
JAK2 | 0.002 | 0.057 | -9999 | 0 | -0.44 | 3 | 3 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JAK1 | 0.005 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
CAMK2D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAPK1 | -0.023 | 0.2 | -9999 | 0 | -0.57 | 18 | 18 |
SMAD7 | 0.017 | 0.057 | -9999 | 0 | -10000 | 0 | 0 |
CBL/CRKL/C3G | 0 | 0.1 | -9999 | 0 | -0.32 | 1 | 1 |
PI3K | -0.04 | 0.089 | -9999 | 0 | -0.34 | 1 | 1 |
IFNG | -0.084 | 0.21 | -9999 | 0 | -0.52 | 35 | 35 |
apoptosis | -0.018 | 0.14 | -9999 | 0 | -0.42 | 17 | 17 |
CAMK2G | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT3 (dimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CAMK2A | -0.042 | 0.17 | -9999 | 0 | -0.6 | 17 | 17 |
CAMK2B | -0.036 | 0.13 | -9999 | 0 | -0.42 | 21 | 21 |
FRAP1 | 0.002 | 0.094 | -9999 | 0 | -10000 | 0 | 0 |
PRKCD | 0.002 | 0.1 | -9999 | 0 | -10000 | 0 | 0 |
RAP1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
negative regulation of cell growth | -0.035 | 0.072 | -9999 | 0 | -0.29 | 5 | 5 |
PTPN2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EP300 | 0.009 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
IRF1 | 0.014 | 0.11 | -9999 | 0 | -0.5 | 3 | 3 |
STAT1 (dimer)/PIASy | -0.008 | 0.12 | -9999 | 0 | -0.46 | 3 | 3 |
SOCS1 | -0.017 | 0.18 | -9999 | 0 | -1.4 | 3 | 3 |
mol:GDP | -0.035 | 0.081 | -9999 | 0 | -0.31 | 1 | 1 |
CASP1 | 0.009 | 0.084 | -9999 | 0 | -0.3 | 9 | 9 |
PTGES2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRF9 | 0.024 | 0.055 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | -0.039 | 0.087 | -9999 | 0 | -0.33 | 1 | 1 |
RAP1/GDP | -0.031 | 0.069 | -9999 | 0 | -10000 | 0 | 0 |
CBL | -0.012 | 0.11 | -9999 | 0 | -0.32 | 4 | 4 |
MAP3K1 | -0.013 | 0.11 | -9999 | 0 | -0.29 | 20 | 20 |
PIAS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIAS4 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
antigen processing and presentation of peptide antigen via MHC class II | -0.035 | 0.072 | -9999 | 0 | -0.29 | 5 | 5 |
PTPN11 | -0.02 | 0.11 | -9999 | 0 | -0.31 | 20 | 20 |
CREBBP | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
RAPGEF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
RIP1/MEKK3 | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to insulin stimulus | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RIPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to stress | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K6 | 0 | 0.086 | -9999 | 0 | -0.58 | 4 | 4 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP2K4 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
RAC1-CDC42/GTP/PAK family | 0.02 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
response to UV | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YES1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
interleukin-1 receptor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
tumor necrosis factor receptor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FYN | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
MAP3K12 | -0.001 | 0.084 | -9999 | 0 | -0.5 | 5 | 5 |
FGR | -0.041 | 0.17 | -9999 | 0 | -0.55 | 18 | 18 |
p38 alpha/TAB1 | -0.038 | 0.092 | -9999 | 0 | -0.44 | 6 | 6 |
PRKG1 | -0.065 | 0.2 | -9999 | 0 | -0.58 | 25 | 25 |
DUSP8 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
PGK/cGMP/p38 alpha | -0.067 | 0.14 | -9999 | 0 | -0.38 | 23 | 23 |
apoptosis | -0.037 | 0.088 | -9999 | 0 | -0.42 | 6 | 6 |
RAL/GTP | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
LYN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DUSP1 | -0.012 | 0.11 | -9999 | 0 | -0.49 | 9 | 9 |
PAK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1/OSM/MEKK3/MKK3 | 0.031 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
epidermal growth factor receptor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:LPS | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:cGMP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CCM2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1-CDC42/GTP | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK11 | -0.026 | 0.15 | -9999 | 0 | -0.44 | 15 | 15 |
BLK | -0.13 | 0.23 | -9999 | 0 | -0.49 | 52 | 52 |
HCK | -0.041 | 0.17 | -9999 | 0 | -0.58 | 17 | 17 |
MAP2K3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DUSP16 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DUSP10 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
TRAF6/MEKK3 | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K7IP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | -0.01 | 0.12 | -9999 | 0 | -0.47 | 6 | 6 |
positive regulation of innate immune response | -0.022 | 0.16 | -9999 | 0 | -0.47 | 14 | 14 |
LCK | -0.051 | 0.16 | -9999 | 0 | -0.47 | 25 | 25 |
p38alpha-beta/MKP7 | -0.015 | 0.15 | -9999 | 0 | -0.52 | 9 | 9 |
p38alpha-beta/MKP5 | -0.017 | 0.16 | -9999 | 0 | -0.48 | 12 | 12 |
PGK/cGMP | -0.048 | 0.15 | -9999 | 0 | -0.43 | 25 | 25 |
PAK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
p38alpha-beta/MKP1 | -0.025 | 0.16 | -9999 | 0 | -0.46 | 16 | 16 |
CDC42 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RALB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RALA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAK3 | -0.004 | 0.068 | -9999 | 0 | -0.42 | 5 | 5 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Telomerase catalytic core complex | -0.1 | 0.27 | -9999 | 0 | -1.2 | 9 | 9 |
RAD9A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AP1 | -0.013 | 0.11 | -9999 | 0 | -0.4 | 14 | 14 |
IFNAR2 | 0.012 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | -0.014 | 0.074 | -9999 | 0 | -0.28 | 3 | 3 |
ER alpha/Oestrogen | -0.047 | 0.14 | -9999 | 0 | -0.39 | 27 | 27 |
NFX1/SIN3/HDAC complex | 0.037 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
EGF | -0.2 | 0.26 | -9999 | 0 | -0.5 | 79 | 79 |
SMG5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMG6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SP3/HDAC2 | 0.018 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
TERT/c-Abl | -0.1 | 0.24 | -9999 | 0 | -1.1 | 9 | 9 |
SAP18 | 0.009 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
MRN complex | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
WT1 | -0.24 | 0.27 | -9999 | 0 | -0.51 | 93 | 93 |
WRN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SP1 | 0.012 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
SP3 | 0.011 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
TERF2IP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase/Nucleolin | -0.095 | 0.21 | -9999 | 0 | -0.94 | 9 | 9 |
Mad/Max | 0.014 | 0.031 | -9999 | 0 | -0.28 | 2 | 2 |
TERT | -0.11 | 0.28 | -9999 | 0 | -1.2 | 9 | 9 |
CCND1 | -0.086 | 0.23 | -9999 | 0 | -0.98 | 9 | 9 |
MAX | 0.011 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
RBBP7 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
RBBP4 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
TERF2 | 0.011 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTGES3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SIN3A | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase/911 | 0.021 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
CDKN1B | -0.03 | 0.14 | -9999 | 0 | -0.39 | 18 | 18 |
RAD1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XRCC5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XRCC6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SAP30 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
TRF2/PARP2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE3A | 0.012 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
JUN | 0.008 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
E6 | 0 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
HPV-16 E6/E6AP | 0.009 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
FOS | -0.027 | 0.14 | -9999 | 0 | -0.55 | 13 | 13 |
IFN-gamma/IRF1 | -0.048 | 0.16 | -9999 | 0 | -0.42 | 24 | 24 |
PARP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BLM | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase | 0.005 | 0.06 | -9999 | 0 | -0.4 | 2 | 2 |
IRF1 | 0.011 | 0.044 | -9999 | 0 | -0.41 | 2 | 2 |
ESR1 | -0.065 | 0.19 | -9999 | 0 | -0.53 | 27 | 27 |
KU/TER | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ATM/TRF2 | 0.019 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ubiquitin-dependent protein catabolic process | 0.041 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
HPV-16 E6/E6AP/NFX1/SIN3/HDAC complex | 0.041 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
HDAC1 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
HDAC2 | 0.012 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
ATM | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMAD3 | 0.001 | 0.094 | -9999 | 0 | -0.44 | 8 | 8 |
ABL1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MXD1 | 0.007 | 0.043 | -9999 | 0 | -0.41 | 2 | 2 |
MRE11A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HUS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RPS6KB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TERT/NF kappa B1/14-3-3 | -0.092 | 0.24 | -9999 | 0 | -1 | 9 | 9 |
NR2F2 | 0.013 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.011 | 0.024 | -9999 | 0 | -0.3 | 1 | 1 |
MAPK1 | 0.011 | 0.024 | -9999 | 0 | -0.3 | 1 | 1 |
TGFB1/TGF beta receptor Type II | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HNRNPC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NBN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.41 | 2 | 2 |
mol:Oestrogen | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
EGF/EGFR | -0.14 | 0.2 | -9999 | 0 | -0.36 | 80 | 80 |
MYC | 0.001 | 0.081 | -9999 | 0 | -0.64 | 3 | 3 |
IL2 | 0.001 | 0.033 | -9999 | 0 | -0.44 | 1 | 1 |
KU | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAD50 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TGFB1 | -0.004 | 0.097 | -9999 | 0 | -0.59 | 5 | 5 |
TRF2/BLM | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FRAP1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KU/TERT | -0.086 | 0.25 | -9999 | 0 | -1.1 | 9 | 9 |
SP1/HDAC2 | 0.019 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
PINX1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase/EST1A | -0.095 | 0.21 | -9999 | 0 | -0.94 | 9 | 9 |
Smad3/Myc | 0.001 | 0.094 | -9999 | 0 | -0.39 | 10 | 10 |
911 complex | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IFNG | -0.081 | 0.21 | -9999 | 0 | -0.51 | 35 | 35 |
Telomerase/PinX1 | -0.095 | 0.21 | -9999 | 0 | -0.94 | 9 | 9 |
Telomerase/AKT1/mTOR/p70S6K | -0.002 | 0.06 | -9999 | 0 | -10000 | 0 | 0 |
SIN3B | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase/EST1B | -0.095 | 0.21 | -9999 | 0 | -0.94 | 9 | 9 |
response to DNA damage stimulus | 0.003 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MRN complex/TRF2/Rap1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRF2/WRN | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Telomerase/hnRNP C1/C2 | -0.095 | 0.21 | -9999 | 0 | -0.94 | 9 | 9 |
E2F1 | 0.012 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
ZNFX1 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
PIF1 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
NCL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DKC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
telomeric DNA binding | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
USP8 | 0.017 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
RAS family/GTP | 0.006 | 0.09 | -10000 | 0 | -0.3 | 4 | 4 |
NFATC4 | 0.004 | 0.092 | -10000 | 0 | -0.41 | 2 | 2 |
ERBB2IP | 0.002 | 0.08 | -10000 | 0 | -0.63 | 3 | 3 |
HSP90 (dimer) | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mammary gland morphogenesis | -0.013 | 0.1 | 0.23 | 1 | -0.32 | 6 | 7 |
JUN | 0.018 | 0.084 | 0.18 | 1 | -0.29 | 3 | 4 |
HRAS | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
DOCK7 | -0.003 | 0.1 | -10000 | 0 | -0.42 | 1 | 1 |
ErbB2/ErbB3/neuregulin 1 beta/SHC | -0.026 | 0.12 | 0.24 | 2 | -0.35 | 18 | 20 |
AKT1 | 0.01 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
BAD | 0.017 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
MAPK10 | -0.011 | 0.09 | -10000 | 0 | -0.28 | 8 | 8 |
mol:GTP | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
ErbB2/ErbB3/neuregulin 1 beta | -0.011 | 0.11 | 0.25 | 1 | -0.35 | 6 | 7 |
RAF1 | 0.017 | 0.095 | -10000 | 0 | -0.32 | 4 | 4 |
ErbB2/ErbB3/neuregulin 2 | -0.002 | 0.064 | 0.24 | 3 | -0.23 | 1 | 4 |
STAT3 | 0.001 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
cell migration | 0.008 | 0.075 | 0.18 | 1 | -0.26 | 3 | 4 |
mol:PI-3-4-5-P3 | 0 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
cell proliferation | -0.003 | 0.21 | -10000 | 0 | -0.61 | 15 | 15 |
FOS | 0.005 | 0.17 | -10000 | 0 | -0.41 | 21 | 21 |
NRAS | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | -0.013 | 0.1 | 0.23 | 1 | -0.32 | 6 | 7 |
MAPK3 | 0.005 | 0.17 | -10000 | 0 | -0.5 | 13 | 13 |
MAPK1 | 0.005 | 0.17 | -10000 | 0 | -0.5 | 13 | 13 |
JAK2 | -0.006 | 0.11 | -10000 | 0 | -0.43 | 2 | 2 |
NF2 | -0.001 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
ErbB2/ErbB3/neuregulin 1 beta/SHC/GRB2/SOS1 | -0.013 | 0.1 | -10000 | 0 | -0.3 | 18 | 18 |
NRG1 | -0.081 | 0.21 | -10000 | 0 | -0.55 | 32 | 32 |
GRB2/SOS1 | 0.018 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.001 | 0.098 | 0.21 | 1 | -0.28 | 18 | 19 |
MAPK9 | 0.013 | 0.058 | -10000 | 0 | -10000 | 0 | 0 |
ERBB2 | 0.003 | 0.059 | 0.4 | 3 | -0.3 | 2 | 5 |
ERBB3 | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | -0.005 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
STAT3 (dimer) | 0.017 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
RNF41 | 0.022 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
FRAP1 | 0.008 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
RAC1-CDC42/GTP | -0.026 | 0.063 | -10000 | 0 | -0.29 | 1 | 1 |
ErbB2/ErbB2/HSP90 (dimer) | 0.002 | 0.042 | 0.27 | 3 | -0.25 | 1 | 4 |
CHRNA1 | -0.007 | 0.2 | -10000 | 0 | -0.61 | 16 | 16 |
myelination | 0.007 | 0.09 | -10000 | 0 | -0.38 | 2 | 2 |
PPP3CB | -0.003 | 0.097 | -10000 | 0 | -0.39 | 1 | 1 |
KRAS | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
RAC1-CDC42/GDP | 0.001 | 0.087 | -10000 | 0 | -0.31 | 1 | 1 |
NRG2 | -0.016 | 0.099 | -10000 | 0 | -0.42 | 11 | 11 |
mol:GDP | -0.013 | 0.1 | -10000 | 0 | -0.3 | 18 | 18 |
SOS1 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K2 | 0.021 | 0.099 | -10000 | 0 | -0.35 | 4 | 4 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:cAMP | -0.001 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PTPN11 | -0.004 | 0.1 | -10000 | 0 | -0.42 | 1 | 1 |
MAP2K1 | 0 | 0.16 | -10000 | 0 | -0.54 | 7 | 7 |
heart morphogenesis | -0.013 | 0.1 | 0.23 | 1 | -0.32 | 6 | 7 |
RAS family/GDP | 0.006 | 0.088 | -10000 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PRKACA | -0.003 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
CHRNE | 0.005 | 0.046 | -10000 | 0 | -0.15 | 14 | 14 |
HSP90AA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
activation of caspase activity | -0.01 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
nervous system development | -0.013 | 0.1 | 0.23 | 1 | -0.32 | 6 | 7 |
CDC42 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HDAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC2 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
GNB1/GNG2 | -0.015 | 0.12 | -9999 | 0 | -0.41 | 16 | 16 |
forebrain development | -0.022 | 0.2 | -9999 | 0 | -0.63 | 14 | 14 |
GNAO1 | -0.098 | 0.22 | -9999 | 0 | -0.53 | 39 | 39 |
SMO/beta Arrestin2 | -0.018 | 0.13 | -9999 | 0 | -0.47 | 14 | 14 |
SMO | -0.038 | 0.17 | -9999 | 0 | -0.61 | 16 | 16 |
ARRB2 | 0.013 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
GLI3/SPOP | 0.012 | 0.092 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
GSK3B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAI2 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
SIN3/HDAC complex | 0.029 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
GNAI1 | -0.008 | 0.11 | -9999 | 0 | -0.63 | 6 | 6 |
XPO1 | 0.014 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
GLI1/Su(fu) | -0.058 | 0.18 | -9999 | 0 | -0.72 | 9 | 9 |
SAP30 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.038 | 0.17 | -9999 | 0 | -0.61 | 16 | 16 |
MIM/GLI2A | -0.02 | 0.15 | -9999 | 0 | -0.6 | 12 | 12 |
IFT88 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNAI3 | 0.012 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
GLI2 | 0.022 | 0.06 | -9999 | 0 | -10000 | 0 | 0 |
GLI3 | 0.006 | 0.097 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1E | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SAP18 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
embryonic digit morphogenesis | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNG2 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
Gi family/GTP | -0.053 | 0.18 | -9999 | 0 | -0.39 | 30 | 30 |
SIN3B | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
SIN3A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GLI3/Su(fu) | 0.022 | 0.075 | -9999 | 0 | -10000 | 0 | 0 |
GLI2/Su(fu) | 0.024 | 0.082 | -9999 | 0 | -10000 | 0 | 0 |
FOXA2 | -0.059 | 0.22 | -9999 | 0 | -0.88 | 12 | 12 |
neural tube patterning | -0.022 | 0.2 | -9999 | 0 | -0.63 | 14 | 14 |
SPOP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Su(fu)/PIAS1 | 0.013 | 0.06 | -9999 | 0 | -10000 | 0 | 0 |
GNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1G2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1G3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MTSS1 | -0.02 | 0.15 | -9999 | 0 | -0.6 | 12 | 12 |
embryonic limb morphogenesis | -0.022 | 0.2 | -9999 | 0 | -0.63 | 14 | 14 |
SUFU | 0.007 | 0.067 | -9999 | 0 | -10000 | 0 | 0 |
LGALS3 | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
catabolic process | 0.023 | 0.11 | -9999 | 0 | -10000 | 0 | 0 |
GLI3A/CBP | -0.001 | 0.085 | -9999 | 0 | -0.36 | 10 | 10 |
KIF3A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GLI1 | -0.024 | 0.2 | -9999 | 0 | -0.65 | 14 | 14 |
RAB23 | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
CSNK1A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IFT172 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RBBP7 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
Su(fu)/Galectin3 | 0.01 | 0.068 | -9999 | 0 | -0.41 | 1 | 1 |
GNAZ | -0.008 | 0.11 | -9999 | 0 | -0.54 | 7 | 7 |
RBBP4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1G1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIAS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GLI2/SPOP | 0.026 | 0.056 | -9999 | 0 | -10000 | 0 | 0 |
STK36 | 0.014 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
Gi family/GNB1/GNG2/GDP | -0.04 | 0.16 | -9999 | 0 | -0.66 | 8 | 8 |
PTCH1 | -0.023 | 0.22 | -9999 | 0 | -0.94 | 8 | 8 |
MIM/GLI1 | -0.029 | 0.22 | -9999 | 0 | -0.69 | 14 | 14 |
CREBBP | -0.001 | 0.085 | -9999 | 0 | -0.36 | 10 | 10 |
Su(fu)/SIN3/HDAC complex | 0.038 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
SPHK2 | 0.011 | 0.055 | -10000 | 0 | -0.32 | 5 | 5 |
MAP4K4 | 0.024 | 0.076 | -10000 | 0 | -0.56 | 2 | 2 |
BAG4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PKC zeta/ceramide | -0.025 | 0.043 | 0.16 | 1 | -10000 | 0 | 1 |
NFKBIA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BIRC3 | -0.016 | 0.12 | -10000 | 0 | -0.48 | 11 | 11 |
BAX | -0.009 | 0.022 | -10000 | 0 | -10000 | 0 | 0 |
RIPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT1 | 0.021 | 0.009 | -10000 | 0 | -10000 | 0 | 0 |
BAD | -0.025 | 0.043 | 0.17 | 1 | -10000 | 0 | 1 |
SMPD1 | 0.015 | 0.049 | -10000 | 0 | -0.22 | 7 | 7 |
RB1 | -0.027 | 0.051 | 0.17 | 1 | -0.41 | 1 | 2 |
FADD/Caspase 8 | 0.033 | 0.073 | -10000 | 0 | -0.53 | 2 | 2 |
MAP2K4 | -0.019 | 0.049 | -10000 | 0 | -0.39 | 1 | 1 |
NSMAF | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to UV | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAF1 | -0.018 | 0.041 | -10000 | 0 | -10000 | 0 | 0 |
EGF | -0.2 | 0.26 | -10000 | 0 | -0.5 | 79 | 79 |
mol:ceramide | -0.035 | 0.046 | 0.17 | 1 | -10000 | 0 | 1 |
MADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to oxidative stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Free Fatty acid | 0.011 | 0.055 | -10000 | 0 | -0.32 | 5 | 5 |
ASAH1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
negative regulation of cell cycle | -0.027 | 0.05 | 0.17 | 1 | -0.4 | 1 | 2 |
cell proliferation | -0.056 | 0.11 | -10000 | 0 | -0.29 | 24 | 24 |
BID | 0.013 | 0.051 | -10000 | 0 | -0.36 | 2 | 2 |
MAP3K1 | -0.025 | 0.043 | 0.17 | 1 | -10000 | 0 | 1 |
EIF2A | -0.012 | 0.045 | -10000 | 0 | -0.32 | 1 | 1 |
TRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK3 | -0.007 | 0.039 | -10000 | 0 | -10000 | 0 | 0 |
response to heat | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | -0.007 | 0.039 | -10000 | 0 | -10000 | 0 | 0 |
Cathepsin D/ceramide | -0.025 | 0.043 | 0.16 | 1 | -10000 | 0 | 1 |
FADD | 0.024 | 0.076 | -10000 | 0 | -0.56 | 2 | 2 |
KSR1 | -0.025 | 0.043 | 0.17 | 1 | -10000 | 0 | 1 |
MAPK8 | -0.014 | 0.043 | 0.17 | 1 | -0.24 | 1 | 2 |
PRKRA | -0.025 | 0.043 | 0.17 | 1 | -10000 | 0 | 1 |
PDGFA | 0 | 0.076 | -10000 | 0 | -0.46 | 5 | 5 |
TRAF2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF1 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 47 | 47 |
mol:GD3 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ganglioside biosynthetic process | -0.034 | 0.046 | 0.17 | 1 | -10000 | 0 | 1 |
CTSD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of nitric oxide biosynthetic process | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to radiation | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ERK1/PKC delta | -0.059 | 0.11 | -10000 | 0 | -0.31 | 24 | 24 |
PRKCD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GW4869 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:sphingosine | 0.011 | 0.055 | -10000 | 0 | -0.32 | 5 | 5 |
RelA/NF kappa B1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:glutathione | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PAWR | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TNF-alpha/TNFR1A/TRADD/MADD/cIAP2/RIP1/TRAF2/RAIDD | 0.018 | 0.08 | -10000 | 0 | -0.59 | 2 | 2 |
TNFR1A/BAG4/TNF-alpha | 0.006 | 0.082 | -10000 | 0 | -0.39 | 7 | 7 |
mol:Sphingosine-1-phosphate | 0.011 | 0.055 | -10000 | 0 | -0.32 | 5 | 5 |
MAP2K1 | -0.011 | 0.039 | -10000 | 0 | -10000 | 0 | 0 |
mol:C11AG | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CYCS | -0.011 | 0.037 | 0.16 | 1 | -10000 | 0 | 1 |
TNFRSF1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TNFR1A/BAG4 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EIF2AK2 | -0.018 | 0.041 | -10000 | 0 | -10000 | 0 | 0 |
TNF-alpha/TNFR1A/FAN | 0.006 | 0.082 | -10000 | 0 | -0.39 | 7 | 7 |
response to hydrogen peroxide | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP8 | 0.029 | 0.044 | -10000 | 0 | -0.28 | 2 | 2 |
MAP2K2 | -0.011 | 0.039 | -10000 | 0 | -10000 | 0 | 0 |
SMPD3 | 0.006 | 0.082 | -10000 | 0 | -0.34 | 8 | 8 |
TNF | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
PKC zeta/PAR4 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:PHOSPHOCHOLINE | 0.066 | 0.1 | 0.24 | 32 | -10000 | 0 | 32 |
NF kappa B1/RelA/I kappa B alpha | 0.036 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AIFM1 | -0.011 | 0.037 | 0.16 | 1 | -10000 | 0 | 1 |
BCL2 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
EEF2K | 0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SNTA1 | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
response to hypoxia | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STMN1 | 0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK12 | -0.002 | 0.098 | -9999 | 0 | -0.36 | 10 | 10 |
CCND1 | 0.008 | 0.04 | -9999 | 0 | -0.2 | 2 | 2 |
p38 gamma/SNTA1 | 0.001 | 0.096 | -9999 | 0 | -0.38 | 7 | 7 |
MAP2K3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PKN1 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
G2/M transition checkpoint | -0.002 | 0.097 | -9999 | 0 | -0.36 | 10 | 10 |
MAP2K6 | 0.007 | 0.071 | -9999 | 0 | -0.33 | 8 | 8 |
MAPT | -0.038 | 0.13 | -9999 | 0 | -0.36 | 22 | 22 |
MAPK13 | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
hyperosmotic response | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ZAK | 0.007 | 0.055 | -9999 | 0 | -0.37 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CCNE1 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
mol:Halofuginone | 0.005 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
ITGA1 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
CDKN1A | 0.013 | 0.071 | -10000 | 0 | -0.56 | 2 | 2 |
PRL-3/alpha Tubulin | 0 | 0.083 | -10000 | 0 | -0.36 | 9 | 9 |
mol:Ca2+ | -0.022 | 0.14 | 0.41 | 4 | -0.42 | 16 | 20 |
AGT | -0.036 | 0.16 | -10000 | 0 | -0.57 | 16 | 16 |
CCNA2 | 0.015 | 0.079 | -10000 | 0 | -10000 | 0 | 0 |
TUBA1B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EGR1 | -0.01 | 0.11 | -10000 | 0 | -0.38 | 15 | 15 |
CDK2/Cyclin E1 | 0.024 | 0.068 | -10000 | 0 | -0.43 | 3 | 3 |
MAPK3 | 0.002 | 0.084 | -10000 | 0 | -0.36 | 9 | 9 |
PRL-2 /Rab GGTase beta | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.002 | 0.084 | -10000 | 0 | -0.36 | 9 | 9 |
PTP4A1 | 0.009 | 0.085 | -10000 | 0 | -0.34 | 8 | 8 |
PTP4A3 | -0.013 | 0.11 | -10000 | 0 | -0.51 | 9 | 9 |
PTP4A2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ITGB1 | 0.002 | 0.084 | -10000 | 0 | -0.36 | 9 | 9 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.007 | 0.072 | -10000 | 0 | -0.4 | 4 | 4 |
Rab GGTase beta/Rab GGTase alpha | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRL-1/ATF-5 | 0.013 | 0.081 | -10000 | 0 | -10000 | 0 | 0 |
RABGGTA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BCAR1 | 0.013 | 0.065 | 0.29 | 9 | -10000 | 0 | 9 |
RHOC | 0.007 | 0.072 | -10000 | 0 | -0.4 | 4 | 4 |
RHOA | 0.007 | 0.072 | -10000 | 0 | -0.4 | 4 | 4 |
cell motility | 0.01 | 0.075 | -10000 | 0 | -0.4 | 4 | 4 |
PRL-1/alpha Tubulin | 0.014 | 0.079 | -10000 | 0 | -10000 | 0 | 0 |
PRL-3/alpha1 Integrin | -0.005 | 0.096 | -10000 | 0 | -0.38 | 11 | 11 |
ROCK1 | 0.01 | 0.075 | -10000 | 0 | -0.4 | 4 | 4 |
RABGGTB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mitosis | 0.009 | 0.084 | -10000 | 0 | -0.34 | 8 | 8 |
ATF5 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MET/RANBP9 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRKL | 0.011 | 0.074 | -10000 | 0 | -0.39 | 1 | 1 |
mol:PIP3 | -0.011 | 0.06 | 0.57 | 2 | -10000 | 0 | 2 |
AKT1 | 0.005 | 0.04 | 0.39 | 2 | -10000 | 0 | 2 |
PTK2B | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAPGEF1 | 0.017 | 0.071 | -10000 | 0 | -0.36 | 1 | 1 |
RANBP10 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HGF/MET/SHIP2 | -0.02 | 0.12 | -10000 | 0 | -0.39 | 16 | 16 |
MAP3K5 | -0.004 | 0.11 | -10000 | 0 | -0.41 | 4 | 4 |
HGF/MET/CIN85/CBL/ENDOPHILINS | -0.012 | 0.12 | -10000 | 0 | -0.35 | 17 | 17 |
AP1 | -0.01 | 0.097 | -10000 | 0 | -0.35 | 14 | 14 |
mol:SU11274 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | -0.022 | 0.16 | -10000 | 0 | -0.74 | 9 | 9 |
STAT3 (dimer) | 0.009 | 0.083 | -10000 | 0 | -10000 | 0 | 0 |
GAB1/CRKL/SHP2/PI3K | -0.017 | 0.054 | -10000 | 0 | -0.34 | 1 | 1 |
INPP5D | -0.012 | 0.12 | -10000 | 0 | -0.64 | 7 | 7 |
CBL/CRK | 0.017 | 0.071 | -10000 | 0 | -0.36 | 1 | 1 |
PTPN11 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GO:0007205 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLCG1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTEN | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
ELK1 | -0.001 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
mol:SU5416 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SHP2/GRB2/SOS1GAB1 | -0.016 | 0.051 | -10000 | 0 | -0.42 | 1 | 1 |
PAK1 | 0.011 | 0.036 | 0.36 | 2 | -10000 | 0 | 2 |
HGF/MET/RANBP10 | -0.02 | 0.12 | -10000 | 0 | -0.39 | 16 | 16 |
HRAS | 0.001 | 0.1 | -10000 | 0 | -0.42 | 1 | 1 |
DOCK1 | 0.017 | 0.071 | -10000 | 0 | -0.36 | 1 | 1 |
GAB1 | 0.004 | 0.078 | -10000 | 0 | -0.41 | 1 | 1 |
CRK | 0.011 | 0.074 | -10000 | 0 | -0.39 | 1 | 1 |
mol:PHA665752 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.045 | 0.14 | -10000 | 0 | -0.5 | 16 | 16 |
JUN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
EntrezGene:200958 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HGF/MET | -0.011 | 0.073 | -10000 | 0 | -0.23 | 16 | 16 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell morphogenesis | 0.032 | 0.087 | -10000 | 0 | -10000 | 0 | 0 |
GRB2/SHC | 0.005 | 0.066 | -10000 | 0 | -0.45 | 1 | 1 |
FOS | -0.026 | 0.14 | -10000 | 0 | -0.55 | 13 | 13 |
GLMN | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell motility | -0.001 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
HGF/MET/MUC20 | -0.028 | 0.12 | -10000 | 0 | -0.35 | 23 | 23 |
cell migration | 0.005 | 0.065 | -10000 | 0 | -0.44 | 1 | 1 |
GRB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CBL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MET/RANBP10 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HGF/MET/Paxillin/FAK1/FAK12/RasGAP | 0.003 | 0.086 | -10000 | 0 | -0.27 | 16 | 16 |
MET/MUC20 | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAP1B | 0.022 | 0.068 | -10000 | 0 | -0.34 | 1 | 1 |
RAP1A | 0.022 | 0.068 | -10000 | 0 | -0.34 | 1 | 1 |
HGF/MET/RANBP9 | -0.02 | 0.12 | -10000 | 0 | -0.39 | 16 | 16 |
RAF1 | 0.007 | 0.096 | -10000 | 0 | -0.39 | 1 | 1 |
STAT3 | 0.009 | 0.084 | -10000 | 0 | -10000 | 0 | 0 |
cell proliferation | 0.01 | 0.12 | -10000 | 0 | -0.36 | 16 | 16 |
RPS6KB1 | 0.004 | 0.027 | -10000 | 0 | -0.16 | 1 | 1 |
MAPK3 | -0.006 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | -0.006 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
RANBP9 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.016 | 0.087 | -10000 | 0 | -0.32 | 3 | 3 |
SRC | 0.01 | 0.081 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | 0.005 | 0.066 | -10000 | 0 | -0.45 | 1 | 1 |
MET/Glomulin | 0.011 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SOS1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | 0.014 | 0.091 | -10000 | 0 | -10000 | 0 | 0 |
MET | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP4K1 | -0.011 | 0.11 | -10000 | 0 | -0.44 | 4 | 4 |
PTK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K2 | 0.014 | 0.091 | -10000 | 0 | -10000 | 0 | 0 |
BAD | 0.011 | 0.036 | 0.36 | 2 | -10000 | 0 | 2 |
MAP2K4 | 0.002 | 0.1 | -10000 | 0 | -0.37 | 4 | 4 |
SHP2/GRB2/SOS1/GAB1 | -0.018 | 0.055 | -10000 | 0 | -0.33 | 1 | 1 |
INPPL1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PXN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SH3KBP1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
HGS | -0.003 | 0.068 | -10000 | 0 | -0.47 | 1 | 1 |
PLCgamma1/PKC | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HGF | -0.058 | 0.19 | -10000 | 0 | -0.57 | 23 | 23 |
RASA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTPRJ | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
NCK/PLCgamma1 | 0.005 | 0.073 | -10000 | 0 | -0.47 | 1 | 1 |
PDPK1 | -0.003 | 0.046 | 0.44 | 2 | -10000 | 0 | 2 |
HGF/MET/SHIP | -0.035 | 0.15 | -10000 | 0 | -0.42 | 22 | 22 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
EP300 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
HDAC4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
induction of apoptosis | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of S phase of mitotic cell cycle | -0.01 | 0.057 | 0.32 | 5 | -10000 | 0 | 5 |
CDKN1A | -0.002 | 0.09 | -10000 | 0 | -0.63 | 3 | 3 |
KAT2B | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
BAX | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO3 | 0.002 | 0.034 | 0.47 | 1 | -10000 | 0 | 1 |
FOXO1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO4 | 0.019 | 0.024 | -10000 | 0 | -0.31 | 1 | 1 |
response to UV | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
XRCC6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TAT | -0.013 | 0.095 | -10000 | 0 | -0.42 | 10 | 10 |
mol:Lysophosphatidic acid | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MYOD1 | 0.008 | 0.035 | -10000 | 0 | -0.47 | 1 | 1 |
PPARGC1A | -0.055 | 0.19 | -10000 | 0 | -0.6 | 21 | 21 |
FHL2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
response to nutrient levels | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KU70/SIRT1 | 0.003 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
HIST2H4A | 0.01 | 0.057 | -10000 | 0 | -0.32 | 5 | 5 |
SIRT1/FOXO3a | 0.003 | 0.026 | 0.3 | 1 | -10000 | 0 | 1 |
SIRT1 | 0.003 | 0.021 | -10000 | 0 | -10000 | 0 | 0 |
response to hypoxia | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SIRT1/MEF2D/HDAC4 | 0.003 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
SIRT1/Histone H1b | -0.009 | 0.052 | -10000 | 0 | -0.26 | 6 | 6 |
apoptosis | -0.003 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
SIRT1/PGC1A | -0.04 | 0.12 | -10000 | 0 | -0.37 | 21 | 21 |
p53/SIRT1 | -0.026 | 0.13 | 0.41 | 2 | -0.47 | 13 | 15 |
SIRT1/FOXO4 | 0.002 | 0.026 | -10000 | 0 | -0.26 | 1 | 1 |
FOXO1/FHL2/SIRT1 | 0.001 | 0.03 | -10000 | 0 | -0.36 | 1 | 1 |
HIST1H1E | 0.004 | 0.063 | -10000 | 0 | -0.31 | 6 | 6 |
SIRT1/p300 | 0.001 | 0.038 | -10000 | 0 | -0.47 | 1 | 1 |
muscle cell differentiation | -0.001 | 0.033 | 0.4 | 1 | -10000 | 0 | 1 |
TP53 | -0.041 | 0.16 | 0.2 | 2 | -0.64 | 13 | 15 |
KU70/SIRT1/BAX | 0.003 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MEF2D | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HIV-1 Tat/SIRT1 | -0.012 | 0.066 | -10000 | 0 | -0.28 | 9 | 9 |
ACSS2 | 0.019 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
SIRT1/PCAF/MYOD | 0.013 | 0.033 | -10000 | 0 | -0.4 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFATC1 | 0.033 | 0.069 | -10000 | 0 | -10000 | 0 | 0 |
NFATC2 | 0.015 | 0.055 | -10000 | 0 | -10000 | 0 | 0 |
NFATC3 | 0.021 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Calcineurin A alpha-beta B1/CABIN1 | -0.067 | 0.16 | -10000 | 0 | -0.48 | 16 | 16 |
Exportin 1/Ran/NUP214 | 0.024 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
mol:DAG | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
CABIN1/MEF2D/CaM/Ca2+/CAMK IV | -0.085 | 0.15 | -10000 | 0 | -0.5 | 16 | 16 |
BCL2/BAX | 0.005 | 0.07 | -10000 | 0 | -0.38 | 6 | 6 |
CaM/Ca2+/Calcineurin A alpha-beta B1 | 0.01 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+ | 0.01 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
BAX | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
BAD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CABIN1/MEF2D | -0.058 | 0.15 | -10000 | 0 | -0.46 | 16 | 16 |
Calcineurin A alpha-beta B1/BCL2 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
FKBP8 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
activation-induced cell death of T cells | 0.057 | 0.15 | 0.45 | 16 | -10000 | 0 | 16 |
KPNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KPNA2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
XPO1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SFN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
MAP3K8 | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
NFAT4/CK1 alpha | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MEF2D/NFAT1/Cbp/p300 | 0.03 | 0.085 | -10000 | 0 | -0.4 | 1 | 1 |
CABIN1 | -0.068 | 0.16 | -10000 | 0 | -0.49 | 16 | 16 |
CALM1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CAMK4 | -0.032 | 0.15 | -10000 | 0 | -0.51 | 16 | 16 |
mol:Ca2+ | 0 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAH | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Calcineurin A alpha-beta B1/AKAP79/PKA | 0.001 | 0.081 | -10000 | 0 | -0.38 | 8 | 8 |
YWHAB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
MAPK9 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAG | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FKBP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFAT1-c-4/YWHAQ | 0.044 | 0.062 | -10000 | 0 | -10000 | 0 | 0 |
PRKCH | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CABIN1/Cbp/p300 | 0.016 | 0.035 | -10000 | 0 | -0.46 | 1 | 1 |
CASP3 | 0.008 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
PIM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Calcineurin A alpha-beta B1/FKBP12/FK506 | 0.008 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | -0.004 | 0.022 | -10000 | 0 | -10000 | 0 | 0 |
14-3-3 family/BAD/CaM/Ca2+/Calcineurin A alpha-beta B1 | 0.037 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
PRKCB | -0.068 | 0.2 | -10000 | 0 | -0.55 | 27 | 27 |
PRKCE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
JNK2/NFAT4 | 0.026 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
BAD/BCL-XL | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NUP214 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKCZ | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
PRKCA | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
PRKCG | -0.15 | 0.24 | -10000 | 0 | -0.49 | 60 | 60 |
PRKCQ | -0.068 | 0.21 | -10000 | 0 | -0.62 | 24 | 24 |
FKBP38/BCL2 | 0.005 | 0.07 | -10000 | 0 | -0.38 | 6 | 6 |
EP300 | 0.009 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
PRKCB1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CSNK2A1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFATc/JNK1 | 0.037 | 0.066 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/FKBP38 | 0.017 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
FKBP12/FK506 | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CSNK1A1 | 0.017 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/CAMK IV | -0.01 | 0.093 | -10000 | 0 | -0.31 | 16 | 16 |
NFATc/ERK1 | 0.039 | 0.066 | -10000 | 0 | -10000 | 0 | 0 |
CABIN1/YWHAQ/CaM/Ca2+/CAMK IV | -0.085 | 0.15 | -10000 | 0 | -0.5 | 16 | 16 |
NR4A1 | 0.023 | 0.12 | -10000 | 0 | -0.48 | 7 | 7 |
GSK3B | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
positive T cell selection | 0.021 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
NFAT1/CK1 alpha | -0.013 | 0.033 | -10000 | 0 | -10000 | 0 | 0 |
RCH1/ KPNB1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAQ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
AKAP5 | -0.01 | 0.11 | -10000 | 0 | -0.52 | 8 | 8 |
MEF2D | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
mol:FK506 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NFATc/p38 alpha | 0.037 | 0.066 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
BCL2 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CRKL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.002 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
DOCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ITGA4 | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
alpha4/beta7 Integrin | -0.027 | 0.15 | -10000 | 0 | -0.48 | 17 | 17 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CRK | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin | 0.006 | 0.082 | -10000 | 0 | -0.39 | 7 | 7 |
alpha4/beta7 Integrin/Paxillin | -0.006 | 0.12 | -10000 | 0 | -0.45 | 12 | 12 |
lamellipodium assembly | 0.003 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TLN1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PXN | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GTP | -0.012 | 0.057 | -10000 | 0 | -10000 | 0 | 0 |
cell adhesion | 0.02 | 0.07 | -10000 | 0 | -0.32 | 7 | 7 |
CRKL/CBL | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin/Paxillin | 0.014 | 0.075 | -10000 | 0 | -0.35 | 7 | 7 |
ITGB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ITGB7 | -0.023 | 0.14 | -10000 | 0 | -0.54 | 12 | 12 |
ARF6/GDP | 0.002 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin/Paxillin/VCAM1 | -0.005 | 0.14 | -10000 | 0 | -0.47 | 12 | 12 |
p130Cas/Crk/Dock1 | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VCAM1 | -0.036 | 0.16 | -10000 | 0 | -0.53 | 17 | 17 |
alpha4/beta1 Integrin/Paxillin/Talin | 0.021 | 0.071 | -10000 | 0 | -0.33 | 7 | 7 |
alpha4/beta1 Integrin/Paxillin/GIT1 | 0.021 | 0.071 | -10000 | 0 | -0.33 | 7 | 7 |
BCAR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.02 | 0.07 | 0.32 | 7 | -10000 | 0 | 7 |
CBL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GIT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
alpha4/beta1 Integrin/Paxillin/Talin/Actin Cytoskeleton | 0.021 | 0.071 | -10000 | 0 | -0.33 | 7 | 7 |
Rac1/GTP | 0.003 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | 0.012 | 0.11 | -10000 | 0 | -0.53 | 4 | 4 |
UGCG | 0.014 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
AKT1/mTOR/p70S6K/Hsp90/TERT | 0.012 | 0.12 | -10000 | 0 | -0.42 | 5 | 5 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:glucosylceramide | 0.014 | 0.029 | -10000 | 0 | -10000 | 0 | 0 |
mol:DAG | -0.001 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/Calcineurin A alpha-beta B1 | -0.039 | 0.11 | -10000 | 0 | -0.42 | 8 | 8 |
FRAP1 | 0.018 | 0.15 | -10000 | 0 | -0.5 | 8 | 8 |
FOXO3 | 0.024 | 0.14 | -10000 | 0 | -0.44 | 7 | 7 |
AKT1 | 0.017 | 0.14 | -10000 | 0 | -0.44 | 10 | 10 |
GAB2 | 0.009 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
SMPD1 | 0.014 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
SGMS1 | 0.014 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of NF-kappaB transcription factor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | 0.019 | 0.004 | -10000 | 0 | -10000 | 0 | 0 |
CALM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
cell proliferation | 0.022 | 0.065 | -10000 | 0 | -0.24 | 2 | 2 |
EIF3A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | 0.022 | 0.005 | -10000 | 0 | -10000 | 0 | 0 |
RPS6KB1 | 0.016 | 0.038 | -10000 | 0 | -0.24 | 1 | 1 |
mol:sphingomyelin | -0.001 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
natural killer cell activation | 0 | 0.002 | -10000 | 0 | -0.012 | 3 | 3 |
JAK3 | 0.004 | 0.07 | -10000 | 0 | -0.47 | 4 | 4 |
PIK3R1 | 0.014 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
JAK1 | 0.011 | 0.047 | -10000 | 0 | -0.63 | 1 | 1 |
NFKB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MYC | 0.017 | 0.17 | -10000 | 0 | -0.88 | 4 | 4 |
MYB | 0.004 | 0.18 | -10000 | 0 | -1.2 | 4 | 4 |
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GAB2/GRB2/SOS1/SHP2/PI3K | 0.01 | 0.14 | -10000 | 0 | -0.46 | 9 | 9 |
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 | 0.027 | 0.041 | -10000 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | 0.011 | 0.14 | -10000 | 0 | -0.45 | 9 | 9 |
Rac1/GDP | 0.025 | 0.006 | -10000 | 0 | -10000 | 0 | 0 |
T cell proliferation | 0.017 | 0.13 | -10000 | 0 | -0.46 | 6 | 6 |
SHC1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of cyclin-dependent protein kinase activity | 0.003 | 0.01 | -10000 | 0 | -0.065 | 4 | 4 |
PRKCZ | 0.016 | 0.13 | -10000 | 0 | -0.48 | 6 | 6 |
NF kappa B1 p50/RelA | -0.037 | 0.1 | -10000 | 0 | -0.43 | 7 | 7 |
IL2/IL2R beta/gamma/JAK1/LCK/JAK3/PI3K | 0.004 | 0.12 | -10000 | 0 | -0.52 | 7 | 7 |
HSP90AA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL2RA | -0.06 | 0.19 | -10000 | 0 | -0.55 | 25 | 25 |
IL2RB | -0.038 | 0.17 | -10000 | 0 | -0.55 | 18 | 18 |
TERT | -0.061 | 0.18 | -10000 | 0 | -0.49 | 28 | 28 |
E2F1 | 0.016 | 0.067 | -10000 | 0 | -0.44 | 4 | 4 |
SOS1 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
RPS6 | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
mol:cAMP | -0.002 | 0.005 | 0.031 | 4 | -10000 | 0 | 4 |
PTPN11 | 0.013 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
IL2RG | 0.007 | 0.063 | -10000 | 0 | -0.49 | 3 | 3 |
actin cytoskeleton organization | 0.017 | 0.13 | -10000 | 0 | -0.46 | 6 | 6 |
GRB2 | 0.012 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
IL2 | 0.004 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
PIK3CA | 0.014 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GTP | 0.032 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
LCK | -0.048 | 0.16 | -10000 | 0 | -0.47 | 25 | 25 |
BCL2 | 0.02 | 0.16 | -10000 | 0 | -0.81 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BAG4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Caspase 8 (4 units) | -0.027 | 0.063 | -9999 | 0 | -10000 | 0 | 0 |
NEF | -0.016 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
NFKBIA | 0.01 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
BIRC3 | 0.011 | 0.12 | -9999 | 0 | -0.65 | 3 | 3 |
CYCS | 0.008 | 0.089 | -9999 | 0 | -10000 | 0 | 0 |
RIPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CD247 | -0.053 | 0.19 | -9999 | 0 | -0.67 | 15 | 15 |
MAP2K7 | 0.016 | 0.075 | -9999 | 0 | -10000 | 0 | 0 |
protein ubiquitination | 0.046 | 0.05 | -9999 | 0 | -10000 | 0 | 0 |
CRADD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAXX | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FAS | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
BID | 0.002 | 0.093 | -9999 | 0 | -0.26 | 16 | 16 |
NF-kappa-B/RelA/I kappa B alpha | -0.013 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
TRADD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CFLAR | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FADD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF-kappa-B/RelA/I kappa B alpha/ubiquitin | -0.013 | 0.054 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.022 | 0.072 | -9999 | 0 | -10000 | 0 | 0 |
APAF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAF1 | 0.005 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
TRAF2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8/FASLG | -0.005 | 0.097 | -9999 | 0 | -0.28 | 17 | 17 |
TNFR1A/Caspase 2/TNF-alpha/FADD/TRADD/RIP1/cIAP2/TRAF1/TRAF2/Ask1/RAIDD | 0.038 | 0.06 | -9999 | 0 | -10000 | 0 | 0 |
CHUK | 0.047 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
FAS/FADD/DAXX/Ask1/Caspase 8/Caspase 8 | 0.034 | 0.026 | -9999 | 0 | -0.33 | 1 | 1 |
TCRz/NEF | -0.072 | 0.18 | -9999 | 0 | -0.5 | 24 | 24 |
TNF | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
FASLG | -0.086 | 0.27 | -9999 | 0 | -0.65 | 31 | 31 |
NFKB1 | 0.01 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
TNFR1A/BAG4/TNF-alpha | 0.006 | 0.082 | -9999 | 0 | -0.39 | 7 | 7 |
CASP6 | -0.014 | 0.036 | -9999 | 0 | -10000 | 0 | 0 |
CASP7 | 0.032 | 0.11 | -9999 | 0 | -0.58 | 3 | 3 |
RELA | 0.01 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
CASP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP3 | 0.03 | 0.12 | -9999 | 0 | -0.55 | 4 | 4 |
TNFRSF1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFR1A/BAG4 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP8 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP9 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K14 | 0.043 | 0.057 | -9999 | 0 | -10000 | 0 | 0 |
APAF-1/Caspase 9 | -0.032 | 0.082 | -9999 | 0 | -0.47 | 3 | 3 |
BCL2 | 0.02 | 0.081 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
adherens junction organization | 0.026 | 0.022 | -10000 | 0 | -0.27 | 1 | 1 |
epithelial cell differentiation | -0.002 | 0.024 | -10000 | 0 | -0.33 | 1 | 1 |
CYFIP2 | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
ENAH | 0.045 | 0.055 | -10000 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
EPHA2 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
MYO6 | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
CTNNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ABI1/Sra1/Nap1 | 0.016 | 0.06 | -10000 | 0 | -0.39 | 4 | 4 |
AQP5 | -0.065 | 0.14 | -10000 | 0 | -0.49 | 16 | 16 |
CTNND1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0.031 | 0.024 | -10000 | 0 | -0.31 | 1 | 1 |
regulation of calcium-dependent cell-cell adhesion | -0.007 | 0.11 | -10000 | 0 | -0.33 | 16 | 16 |
EGF | -0.2 | 0.26 | -10000 | 0 | -0.5 | 79 | 79 |
NCKAP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AQP3 | -0.024 | 0.07 | -10000 | 0 | -0.49 | 3 | 3 |
cortical microtubule organization | -0.002 | 0.024 | -10000 | 0 | -0.33 | 1 | 1 |
GO:0000145 | 0.03 | 0.023 | -10000 | 0 | -0.29 | 1 | 1 |
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin | 0.027 | 0.026 | -10000 | 0 | -0.33 | 1 | 1 |
MLLT4 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
ARF6/GDP | -0.005 | 0.033 | -10000 | 0 | -10000 | 0 | 0 |
ARF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin A1/EPHA2/NCK1/GIT1 | 0.026 | 0.042 | -10000 | 0 | -0.35 | 2 | 2 |
mol:Ca2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VASP | 0.04 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
PVRL2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ZYX | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
ARF6/GTP | -0.004 | 0.035 | -10000 | 0 | -0.32 | 2 | 2 |
CDH1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EGFR/EGFR/EGF/EGF | -0.093 | 0.12 | -10000 | 0 | -0.35 | 1 | 1 |
RhoA/GDP | -0.002 | 0.022 | -10000 | 0 | -0.31 | 1 | 1 |
actin cytoskeleton organization | 0.036 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
IGF-1R heterotetramer | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GIT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF1R | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IGF1 | -0.12 | 0.24 | -10000 | 0 | -0.53 | 47 | 47 |
DIAPH1 | -0.013 | 0.086 | -10000 | 0 | -0.6 | 4 | 4 |
Wnt receptor signaling pathway | 0.002 | 0.024 | 0.33 | 1 | -10000 | 0 | 1 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoA/GTP | -0.005 | 0.033 | -10000 | 0 | -10000 | 0 | 0 |
CTNNA1 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
VCL | 0.037 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
EFNA1 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
LPP | 0.036 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
Ephrin A1/EPHA2 | -0.005 | 0.039 | -10000 | 0 | -10000 | 0 | 0 |
SEC6/SEC8 | -0.004 | 0.034 | -10000 | 0 | -10000 | 0 | 0 |
MGAT3 | -0.007 | 0.11 | -10000 | 0 | -0.34 | 16 | 16 |
HGF/MET | -0.032 | 0.088 | -10000 | 0 | -10000 | 0 | 0 |
HGF | -0.058 | 0.19 | -10000 | 0 | -0.57 | 23 | 23 |
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN | 0.026 | 0.022 | -10000 | 0 | -0.28 | 1 | 1 |
actin cable formation | 0.06 | 0.043 | -10000 | 0 | -10000 | 0 | 0 |
KIAA1543 | 0.037 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
KIFC3 | 0.024 | 0.054 | -10000 | 0 | -0.31 | 4 | 4 |
NCK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EXOC3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ACTN1 | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
NCK1/GIT1 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | -0.002 | 0.024 | -10000 | 0 | -0.33 | 1 | 1 |
EXOC4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
STX4 | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
PIP5K1C | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
LIMA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ABI1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ROCK1 | 0.048 | 0.042 | -10000 | 0 | -10000 | 0 | 0 |
adherens junction assembly | 0.043 | 0.057 | -10000 | 0 | -0.36 | 3 | 3 |
IGF-1R heterotetramer/IGF1 | -0.058 | 0.11 | -10000 | 0 | -10000 | 0 | 0 |
nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
MET | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLEKHA7 | 0.032 | 0.025 | -10000 | 0 | -0.31 | 1 | 1 |
mol:GTP | 0.025 | 0.042 | -10000 | 0 | -0.35 | 2 | 2 |
establishment of epithelial cell apical/basal polarity | 0.049 | 0.038 | -10000 | 0 | -10000 | 0 | 0 |
cortical actin cytoskeleton stabilization | 0.026 | 0.022 | -10000 | 0 | -0.27 | 1 | 1 |
regulation of cell-cell adhesion | 0.036 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton | 0.026 | 0.022 | -10000 | 0 | -0.28 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CBL/APS/CAP | -0.027 | 0.081 | -9999 | 0 | -10000 | 0 | 0 |
TC10/GTP | -0.016 | 0.061 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/IRS1/Shp2 | 0.013 | 0.07 | -9999 | 0 | -0.37 | 6 | 6 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
APS homodimer | 0.005 | 0.066 | -9999 | 0 | -0.63 | 2 | 2 |
GRB14 | -0.17 | 0.27 | -9999 | 0 | -0.54 | 63 | 63 |
FOXO3 | -0.016 | 0.054 | -9999 | 0 | -0.69 | 1 | 1 |
AKT1 | -0.052 | 0.14 | -9999 | 0 | -0.55 | 1 | 1 |
INSR | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin | 0.031 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRB10 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
SORBS1 | -0.018 | 0.12 | -9999 | 0 | -0.52 | 11 | 11 |
CRK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTPN1 | 0.03 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
CAV1 | 0.003 | 0.08 | -9999 | 0 | -0.34 | 8 | 8 |
CBL/APS/CAP/Crk-II/C3G | 0.016 | 0.076 | -9999 | 0 | -0.33 | 7 | 7 |
Insulin Receptor/Insulin/IRS1/NCK2 | 0.013 | 0.07 | -9999 | 0 | -0.37 | 6 | 6 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | -0.011 | 0.056 | -9999 | 0 | -0.32 | 6 | 6 |
Insulin Receptor/Insuli/IRS1/GRB2/SHC/PTP1B | 0.026 | 0.046 | -9999 | 0 | -10000 | 0 | 0 |
RPS6KB1 | -0.042 | 0.13 | -9999 | 0 | -0.5 | 1 | 1 |
PARD6A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CBL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
tumor necrosis factor-mediated signaling pathway | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DOK1 | 0.001 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insuli/IRS1/GRB2/Shc | -0.07 | 0.1 | -9999 | 0 | -0.51 | 1 | 1 |
HRAS/GTP | -0.019 | 0.074 | -9999 | 0 | -0.56 | 1 | 1 |
Insulin Receptor | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insuli/IRS1/GRB2/SHC | 0.019 | 0.065 | -9999 | 0 | -0.34 | 6 | 6 |
PRKCI | -0.023 | 0.058 | -9999 | 0 | -0.72 | 1 | 1 |
Insulin Receptor/Insulin/GRB14/PDK1 | -0.087 | 0.13 | -9999 | 0 | -0.6 | 1 | 1 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
negative regulation of MAPKKK cascade | 0.001 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | -0.011 | 0.057 | -9999 | 0 | -0.32 | 6 | 6 |
NCK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOQ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:H2O2 | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
HRAS/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT2 | -0.052 | 0.14 | -9999 | 0 | -0.55 | 1 | 1 |
PRKCZ | -0.02 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
SH2B2 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
SHC/SHIP | 0.006 | 0.094 | -9999 | 0 | -0.35 | 12 | 12 |
F2RL2 | -0.067 | 0.2 | -9999 | 0 | -0.59 | 25 | 25 |
TRIP10 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/Shc | 0.017 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
TC10/GTP/CIP4/Exocyst | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/SHC/GRB2/Sos1 | 0.031 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
RAPGEF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RASA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CBL/APS/CAP/Crk-II | 0.01 | 0.081 | -9999 | 0 | -0.35 | 7 | 7 |
TC10/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/SHC/GRB10 | 0.023 | 0.032 | -9999 | 0 | -0.37 | 1 | 1 |
INPP5D | -0.002 | 0.099 | -9999 | 0 | -0.37 | 12 | 12 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SGK1 | -0.013 | 0.07 | -9999 | 0 | -0.95 | 1 | 1 |
mol:cAMP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IRS1 | -0.008 | 0.11 | -9999 | 0 | -0.64 | 6 | 6 |
p62DOK/RasGAP | 0.001 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
INS | 0.001 | 0.03 | -9999 | 0 | -0.41 | 1 | 1 |
mol:PI-3-4-P2 | -0.001 | 0.098 | -9999 | 0 | -0.37 | 12 | 12 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EIF4EBP1 | -0.042 | 0.13 | -9999 | 0 | -0.5 | 1 | 1 |
PTPRA | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TC10/GTP/CIP4 | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PDPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insuli/IRS1/GRB2/SHC/Sos | 0.02 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin/IRS1 | 0.005 | 0.07 | -9999 | 0 | -0.37 | 6 | 6 |
Insulin Receptor/Insulin/IRS3 | 0.011 | 0.021 | -9999 | 0 | -0.28 | 1 | 1 |
Par3/Par6 | -0.015 | 0.11 | -9999 | 0 | -0.33 | 20 | 20 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HIF3A | -0.069 | 0.19 | -9999 | 0 | -0.5 | 30 | 30 |
oxygen homeostasis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TCEB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TCEB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/p53 | 0.003 | 0.087 | -9999 | 0 | -0.31 | 13 | 13 |
HIF1A | 0.019 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
COPS5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VHL/Elongin B/Elongin C/RBX1/CUL2 | 0.036 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FIH (dimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDKN2A | -0.056 | 0.18 | -9999 | 0 | -0.49 | 26 | 26 |
ARNT/IPAS | -0.041 | 0.14 | -9999 | 0 | -0.36 | 30 | 30 |
HIF1AN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNB2L1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/ARNT | 0.026 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
CUL2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
OS9 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RACK1/Elongin B/Elongin C | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to hypoxia | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/Hsp90 | 0.026 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
PHD1-3/OS9 | 0.02 | 0.057 | -9999 | 0 | -0.35 | 3 | 3 |
HIF1A/RACK1/Elongin B/Elongin C | -0.001 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
VHL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/JAB1 | 0.026 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
EGLN3 | -0.007 | 0.1 | -9999 | 0 | -0.51 | 7 | 7 |
EGLN2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGLN1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TP53 | -0.032 | 0.16 | -9999 | 0 | -0.64 | 13 | 13 |
VHL/Elongin B/Elongin C/RBX1/CUL2/HIF1A | 0.034 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
ARNT | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARD1A | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RBX1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HIF1A/p19ARF | -0.007 | 0.087 | -9999 | 0 | -0.3 | 9 | 9 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
cAMP biosynthetic process | -0.002 | 0.08 | 0.63 | 3 | -10000 | 0 | 3 |
PI3K Class IB/PDE3B | 0.002 | 0.08 | -10000 | 0 | -0.63 | 3 | 3 |
PDE3B | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HDAC1 | 0.018 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
SMARCC1 | 0.005 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
REL | 0.015 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
HDAC7 | 0.023 | 0.085 | -9999 | 0 | -0.4 | 1 | 1 |
JUN | 0.005 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
EP300 | 0.008 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
KAT2B | 0.008 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
KAT5 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.011 | 0.065 | -9999 | 0 | -0.42 | 4 | 4 |
FOXO1 | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR | 0.018 | 0.09 | -9999 | 0 | -0.42 | 1 | 1 |
MAP2K6 | -0.001 | 0.086 | -9999 | 0 | -0.58 | 4 | 4 |
BRM/BAF57 | 0.01 | 0.036 | -9999 | 0 | -0.47 | 1 | 1 |
MAP2K4 | 0.008 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
SMARCA2 | 0.006 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
PDE9A | -0.11 | 0.33 | -9999 | 0 | -1.1 | 19 | 19 |
NCOA2 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
CEBPA | -0.004 | 0.1 | -9999 | 0 | -0.63 | 5 | 5 |
EHMT2 | 0.009 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
cell proliferation | 0.025 | 0.11 | -9999 | 0 | -0.42 | 3 | 3 |
NR0B1 | 0 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
EGR1 | -0.033 | 0.15 | -9999 | 0 | -0.53 | 15 | 15 |
RXRs/9cRA | 0.002 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
AR/RACK1/Src | 0.011 | 0.069 | -9999 | 0 | -0.41 | 1 | 1 |
AR/GR | -0.022 | 0.12 | -9999 | 0 | -0.42 | 9 | 9 |
GNB2L1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
PKN1 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
RCHY1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
epidermal growth factor receptor activity | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.017 | 0.036 | -9999 | 0 | -0.46 | 1 | 1 |
T-DHT/AR/TIF2/CARM1 | 0.018 | 0.081 | -9999 | 0 | -0.4 | 3 | 3 |
SRC | 0.025 | 0.057 | -9999 | 0 | -0.32 | 4 | 4 |
NR3C1 | -0.013 | 0.11 | -9999 | 0 | -0.51 | 9 | 9 |
KLK3 | -0.22 | 0.39 | -9999 | 0 | -1.1 | 25 | 25 |
APPBP2 | 0.012 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
TRIM24 | 0.009 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
T-DHT/AR/TIP60 | 0.014 | 0.07 | -9999 | 0 | -0.36 | 4 | 4 |
TMPRSS2 | -0.029 | 0.14 | -9999 | 0 | -0.8 | 4 | 4 |
RXRG | -0.017 | 0.099 | -9999 | 0 | -0.42 | 11 | 11 |
mol:9cRA | -0.001 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
RXRA | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
RXRB | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
CARM1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
NR2C2 | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
KLK2 | 0.018 | 0.093 | -9999 | 0 | -10000 | 0 | 0 |
AR | -0.017 | 0.1 | -9999 | 0 | -0.29 | 15 | 15 |
SENP1 | 0.011 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MDM2 | 0.017 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
SRY | -0.001 | 0.051 | -9999 | 0 | -0.4 | 3 | 3 |
GATA2 | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
MYST2 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
HOXB13 | -0.05 | 0.17 | -9999 | 0 | -0.52 | 21 | 21 |
T-DHT/AR/RACK1/Src | 0.02 | 0.069 | -9999 | 0 | -0.43 | 1 | 1 |
positive regulation of transcription | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
DNAJA1 | 0.012 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.028 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
NCOA1 | 0.012 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
SPDEF | -0.17 | 0.26 | -9999 | 0 | -0.53 | 64 | 64 |
T-DHT/AR/TIF2 | 0.019 | 0.072 | -9999 | 0 | -0.44 | 2 | 2 |
T-DHT/AR/Hsp90 | 0.012 | 0.07 | -9999 | 0 | -0.4 | 2 | 2 |
GSK3B | 0.012 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
NR2C1 | 0.013 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
mol:T-DHT | 0.02 | 0.061 | -9999 | 0 | -0.35 | 4 | 4 |
SIRT1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
ZMIZ2 | 0.018 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
POU2F1 | 0.012 | 0.073 | -9999 | 0 | -0.63 | 2 | 2 |
T-DHT/AR/DAX-1 | -0.009 | 0.069 | -9999 | 0 | -0.37 | 4 | 4 |
CREBBP | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
SMARCE1 | 0.009 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
G beta1gamma2/HDAC5 | 0.024 | 0.045 | -9999 | 0 | -0.35 | 2 | 2 |
HDAC3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1/HDAC4 | -0.001 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
GATA1/HDAC4 | 0.015 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
GATA1/HDAC5 | 0.015 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
GATA2/HDAC5 | -0.004 | 0.094 | -9999 | 0 | -0.39 | 10 | 10 |
HDAC5/BCL6/BCoR | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
HDAC9 | -0.051 | 0.18 | -9999 | 0 | -0.54 | 22 | 22 |
Glucocorticoid receptor/Hsp90/HDAC6 | 0.009 | 0.071 | -9999 | 0 | -0.39 | 4 | 4 |
HDAC4/ANKRA2 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC5/YWHAB | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NPC/RanGAP1/SUMO1/Ubc9 | 0.019 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
GATA2 | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
HDAC4/RFXANK | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCOR | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC10 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNB1/GNG2 | 0.01 | 0.058 | -9999 | 0 | -0.38 | 4 | 4 |
Histones | 0.014 | 0.065 | -9999 | 0 | -10000 | 0 | 0 |
ADRBK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XPO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC5/ANKRA2 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC4/Ubc9 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC5/14-3-3 E | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TUBA1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC5/RFXANK | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CAMK4 | -0.032 | 0.15 | -9999 | 0 | -0.51 | 16 | 16 |
Tubulin/HDAC6 | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
SUMO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:9972 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATA1 | 0.008 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:8021 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NR3C1 | -0.013 | 0.11 | -9999 | 0 | -0.51 | 9 | 9 |
SUMO1/HDAC4 | 0.027 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
SRF | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC4/YWHAB | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Tubulin | 0.016 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
HDAC4/14-3-3 E | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RANGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCL6/BCoR | 0.016 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
HDAC4/HDAC3/SMRT (N-CoR2) | 0.022 | 0.03 | -9999 | 0 | -0.39 | 1 | 1 |
HDAC4/SRF | -0.003 | 0.093 | -9999 | 0 | -0.39 | 7 | 7 |
HDAC4/ER alpha | -0.038 | 0.14 | -9999 | 0 | -0.38 | 27 | 27 |
EntrezGene:23225 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of chromatin silencing | 0.014 | 0.065 | -9999 | 0 | -10000 | 0 | 0 |
cell motility | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:23636 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE2I | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC7/HDAC3 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCL6 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
HDAC4/CaMK II delta B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Hsp90/HDAC6 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ESR1 | -0.064 | 0.19 | -9999 | 0 | -0.53 | 27 | 27 |
HDAC6/HDAC11 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1 | 0.029 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
NPC | 0.006 | 0.015 | -9999 | 0 | -0.21 | 1 | 1 |
MEF2C | -0.007 | 0.1 | -9999 | 0 | -0.51 | 7 | 7 |
RAN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC4/MEF2C | 0.024 | 0.06 | -9999 | 0 | -0.33 | 4 | 4 |
GNG2 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
NCOR2 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
TUBB2A | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
HDAC11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RANBP2 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
ANKRA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RFXANK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
nuclear import | -0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PLAUR | 0.025 | 0.085 | -10000 | 0 | -1.1 | 1 | 1 |
regulation of axonogenesis | -0.025 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
myoblast fusion | -0.012 | 0.034 | 0.41 | 1 | -10000 | 0 | 1 |
mol:GTP | -0.002 | 0.017 | -10000 | 0 | -0.23 | 1 | 1 |
regulation of calcium-dependent cell-cell adhesion | 0.022 | 0.12 | 0.37 | 16 | -10000 | 0 | 16 |
ARF1/GTP | -0.001 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
mol:GM1 | 0.008 | 0.014 | -10000 | 0 | -0.17 | 1 | 1 |
mol:Choline | 0.024 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
lamellipodium assembly | 0.011 | 0.049 | -10000 | 0 | -0.45 | 1 | 1 |
MAPK3 | 0.02 | 0.028 | -10000 | 0 | -0.34 | 1 | 1 |
ARF6/GTP/NME1/Tiam1 | -0.022 | 0.13 | -10000 | 0 | -0.38 | 16 | 16 |
ARF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GDP | 0.012 | 0.034 | -10000 | 0 | -0.41 | 1 | 1 |
ARF1/GDP | 0.029 | 0.037 | -10000 | 0 | -0.38 | 1 | 1 |
ARF6 | 0.011 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
RAB11A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TIAM1 | -0.074 | 0.2 | -10000 | 0 | -0.53 | 31 | 31 |
fibronectin binding | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.02 | 0.028 | -10000 | 0 | -0.34 | 1 | 1 |
actin filament bundle formation | -0.017 | 0.032 | 0.38 | 1 | -10000 | 0 | 1 |
KALRN | 0.006 | 0.051 | -10000 | 0 | -0.34 | 3 | 3 |
RAB11FIP3/RAB11A | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RhoA/GDP | 0.017 | 0.032 | -10000 | 0 | -0.38 | 1 | 1 |
NME1 | 0.013 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.017 | 0.032 | -10000 | 0 | -0.38 | 1 | 1 |
substrate adhesion-dependent cell spreading | -0.002 | 0.017 | -10000 | 0 | -0.23 | 1 | 1 |
cortical actin cytoskeleton organization | 0.011 | 0.05 | -10000 | 0 | -0.45 | 1 | 1 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
liver development | -0.002 | 0.017 | -10000 | 0 | -0.23 | 1 | 1 |
ARF6/GTP | -0.002 | 0.017 | -10000 | 0 | -0.23 | 1 | 1 |
RhoA/GTP | -0.001 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | 0.01 | 0.046 | -10000 | 0 | -0.42 | 1 | 1 |
ARF6/GTP/RAB11FIP3/RAB11A | -0.001 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLD1 | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
RAB11FIP3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
tube morphogenesis | 0.011 | 0.049 | -10000 | 0 | -0.45 | 1 | 1 |
ruffle organization | 0.025 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
regulation of epithelial cell migration | -0.002 | 0.017 | -10000 | 0 | -0.23 | 1 | 1 |
PLD2 | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
PIP5K1A | 0.025 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
mol:Phosphatidic acid | 0.024 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
Rac1/GTP | 0.011 | 0.05 | -10000 | 0 | -0.45 | 1 | 1 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
alphaV beta3 Integrin | -0.005 | 0.097 | -9999 | 0 | -0.41 | 10 | 10 |
AKT1 | 0.064 | 0.086 | -9999 | 0 | -0.55 | 3 | 3 |
PTK2B | 0.028 | 0.12 | -9999 | 0 | -0.92 | 2 | 2 |
VEGFR2 homodimer/Frs2 | 0.024 | 0.08 | -9999 | 0 | -0.75 | 2 | 2 |
CAV1 | -0.004 | 0.089 | -9999 | 0 | -0.49 | 6 | 6 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/Frs2 | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
endothelial cell proliferation | 0.048 | 0.11 | -9999 | 0 | -0.65 | 2 | 2 |
mol:Ca2+ | 0.041 | 0.073 | -9999 | 0 | -0.63 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Rac | 0.039 | 0.073 | -9999 | 0 | -0.66 | 2 | 2 |
RP11-342D11.1 | 0.034 | 0.072 | -9999 | 0 | -0.64 | 2 | 2 |
CDH5 | 0.001 | 0.078 | -9999 | 0 | -0.52 | 4 | 4 |
VEGFA homodimer | 0.032 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SHC2 | -0.059 | 0.19 | -9999 | 0 | -0.55 | 24 | 24 |
HRAS/GDP | -0.007 | 0.057 | -9999 | 0 | -0.54 | 2 | 2 |
SH2D2A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/SHP1/eNOS | -0.017 | 0.082 | -9999 | 0 | -0.52 | 3 | 3 |
VEGFR2 homodimer/VEGFA homodimer/TsAd | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
VEGFR1 homodimer | 0.005 | 0.066 | -9999 | 0 | -0.63 | 2 | 2 |
SHC/GRB2/SOS1 | -0.007 | 0.063 | -9999 | 0 | -0.6 | 2 | 2 |
GRB10 | 0.04 | 0.086 | -9999 | 0 | -0.64 | 3 | 3 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/IQGAP1/Cadherin/beta catenin | -0.012 | 0.086 | -9999 | 0 | -0.79 | 2 | 2 |
HRAS | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGF/Rho/ROCK1/Integrin Complex | 0.03 | 0.078 | -9999 | 0 | -0.57 | 2 | 2 |
HIF1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FRS2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
oxygen and reactive oxygen species metabolic process | -0.007 | 0.066 | -9999 | 0 | -0.65 | 2 | 2 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FLT4 | -0.012 | 0.12 | -9999 | 0 | -0.55 | 8 | 8 |
Nck/Pak | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/Fyn | 0.029 | 0.086 | -9999 | 0 | -0.63 | 3 | 3 |
mol:GDP | -0.007 | 0.061 | -9999 | 0 | -0.58 | 2 | 2 |
mol:NADP | 0.05 | 0.091 | -9999 | 0 | -0.41 | 7 | 7 |
eNOS/Hsp90 | 0.053 | 0.087 | -9999 | 0 | -0.43 | 3 | 3 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:IP3 | 0.042 | 0.073 | -9999 | 0 | -0.64 | 2 | 2 |
HIF1A/ARNT | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SHB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFA | 0.014 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
VEGFC | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
FAK1/Vinculin | 0.046 | 0.1 | -9999 | 0 | -0.87 | 2 | 2 |
mol:Ca ++ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/alphaV beta3 Integrin | 0.022 | 0.12 | -9999 | 0 | -0.98 | 2 | 2 |
PTPN6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EPAS1 | 0.017 | 0.038 | -9999 | 0 | -0.36 | 2 | 2 |
mol:L-citrulline | 0.05 | 0.091 | -9999 | 0 | -0.41 | 7 | 7 |
ITGAV | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/Frs2/GRB2 | 0.039 | 0.073 | -9999 | 0 | -0.66 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer | 0.037 | 0.079 | -9999 | 0 | -0.69 | 2 | 2 |
VEGFR2/3 heterodimer | 0.01 | 0.12 | -9999 | 0 | -0.56 | 6 | 6 |
VEGFB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK11 | 0.043 | 0.076 | -9999 | 0 | -0.65 | 2 | 2 |
VEGFR2 homodimer | 0.022 | 0.09 | -9999 | 0 | -0.85 | 2 | 2 |
FLT1 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
NEDD4 | 0.014 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.029 | 0.089 | -9999 | 0 | -0.58 | 3 | 3 |
MAPK1 | 0.029 | 0.089 | -9999 | 0 | -0.58 | 3 | 3 |
VEGFA145/NRP2 | -0.001 | 0.09 | -9999 | 0 | -0.37 | 10 | 10 |
VEGFR1/2 heterodimer | 0.02 | 0.09 | -9999 | 0 | -0.57 | 4 | 4 |
KDR | 0.022 | 0.09 | -9999 | 0 | -0.85 | 2 | 2 |
VEGFA165/NRP1/VEGFR2 homodimer | 0.027 | 0.11 | -9999 | 0 | -0.79 | 2 | 2 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
platelet activating factor biosynthetic process | 0.032 | 0.09 | -9999 | 0 | -0.59 | 3 | 3 |
PI3K | 0.054 | 0.1 | -9999 | 0 | -0.66 | 3 | 3 |
VEGFR2 homodimer/VEGFA homodimer/NCK1 | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
FES | 0.036 | 0.098 | -9999 | 0 | -0.81 | 2 | 2 |
GAB1 | -0.011 | 0.076 | -9999 | 0 | -0.65 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/Src | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARNT | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
eNOS/Caveolin-1 | 0.046 | 0.095 | -9999 | 0 | -0.43 | 3 | 3 |
VEGFR2 homodimer/VEGFA homodimer/Yes | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
PI3K/GAB1 | 0.066 | 0.086 | -9999 | 0 | -0.63 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/Frs2/Nck/Pak | -0.007 | 0.065 | -9999 | 0 | -0.63 | 2 | 2 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2/3 heterodimer/VEGFC homodimer | 0.001 | 0.15 | -9999 | 0 | -0.78 | 4 | 4 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42 | 0.042 | 0.075 | -9999 | 0 | -0.65 | 2 | 2 |
actin cytoskeleton reorganization | 0.032 | 0.075 | -9999 | 0 | -0.69 | 2 | 2 |
PTK2 | 0.04 | 0.11 | -9999 | 0 | -0.96 | 2 | 2 |
EDG1 | 0.034 | 0.072 | -9999 | 0 | -0.64 | 2 | 2 |
mol:DAG | 0.042 | 0.073 | -9999 | 0 | -0.64 | 2 | 2 |
CaM/Ca2+ | 0.044 | 0.068 | -9999 | 0 | -0.58 | 2 | 2 |
MAP2K3 | 0.047 | 0.071 | -9999 | 0 | -0.61 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/GRB10/NEDD4 | 0.041 | 0.088 | -9999 | 0 | -0.66 | 3 | 3 |
PLCG1 | 0.042 | 0.075 | -9999 | 0 | -0.65 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/Src/Shb | 0.039 | 0.073 | -9999 | 0 | -0.66 | 2 | 2 |
IQGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YES1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR2 homodimer/VEGFA homodimer/SHP2 | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/SHP1 | 0.033 | 0.076 | -9999 | 0 | -0.7 | 2 | 2 |
cell migration | 0.064 | 0.093 | -9999 | 0 | -0.73 | 2 | 2 |
mol:PI-3-4-5-P3 | 0.053 | 0.091 | -9999 | 0 | -0.6 | 3 | 3 |
FYN | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
VEGFB/NRP1 | 0.039 | 0.069 | -9999 | 0 | -0.6 | 2 | 2 |
mol:NO | 0.05 | 0.091 | -9999 | 0 | -0.41 | 7 | 7 |
PXN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HRAS/GTP | -0.007 | 0.057 | -9999 | 0 | -0.54 | 2 | 2 |
VEGFR2 homodimer/VEGFA homodimer/GRB10 | 0.041 | 0.088 | -9999 | 0 | -0.66 | 3 | 3 |
VHL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ITGB3 | -0.018 | 0.13 | -9999 | 0 | -0.57 | 10 | 10 |
NOS3 | 0.05 | 0.1 | -9999 | 0 | -0.46 | 7 | 7 |
VEGFR2 homodimer/VEGFA homodimer/Sck | -0.008 | 0.13 | -9999 | 0 | -0.38 | 17 | 17 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCA | 0.043 | 0.077 | -9999 | 0 | -0.59 | 2 | 2 |
PRKCB | 0.005 | 0.14 | -9999 | 0 | -0.8 | 3 | 3 |
VCL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFA165/NRP1 | 0.034 | 0.073 | -9999 | 0 | -0.64 | 2 | 2 |
VEGFR1/2 heterodimer/VEGFA homodimer | 0.029 | 0.085 | -9999 | 0 | -0.7 | 2 | 2 |
VEGFA165/NRP2 | -0.001 | 0.09 | -9999 | 0 | -0.37 | 10 | 10 |
MAPKKK cascade | 0.059 | 0.075 | -9999 | 0 | -0.54 | 3 | 3 |
NRP2 | -0.016 | 0.12 | -9999 | 0 | -0.52 | 10 | 10 |
VEGFC homodimer | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ROCK1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
FAK1/Paxillin | 0.046 | 0.1 | -9999 | 0 | -0.87 | 2 | 2 |
MAP3K13 | 0.042 | 0.075 | -9999 | 0 | -0.65 | 2 | 2 |
PDPK1 | 0.058 | 0.082 | -9999 | 0 | -0.53 | 3 | 3 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
PDGFRA | -0.034 | 0.16 | -10000 | 0 | -0.62 | 14 | 14 |
HRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
AKT | 0.013 | 0.086 | -10000 | 0 | -0.36 | 7 | 7 |
FOXO3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT3 | -0.024 | 0.14 | -10000 | 0 | -0.52 | 13 | 13 |
FOXO4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MET | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CG | -0.067 | 0.2 | -10000 | 0 | -0.57 | 26 | 26 |
PIK3R3 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
PIK3R2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAS | 0.011 | 0.046 | -10000 | 0 | -0.21 | 1 | 1 |
ERBB2 | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
proliferation/survival/translation | -0.017 | 0.046 | 0.22 | 4 | -10000 | 0 | 4 |
PI3K | 0.009 | 0.06 | -10000 | 0 | -0.22 | 5 | 5 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KRAS | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO | 0.036 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
AKT2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PTEN | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Gs family/GDP/Gbeta gamma | -0.001 | 0.08 | -10000 | 0 | -0.35 | 7 | 7 |
MAPK9 | 0.008 | 0 | -10000 | 0 | -10000 | 0 | 0 |
adrenocorticotropin secretion | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
GNB1/GNG2 | 0.009 | 0.049 | -10000 | 0 | -0.32 | 4 | 4 |
GNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
regulation of calcium ion transport via voltage-gated calcium channel activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.008 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Gs family/GTP | -0.01 | 0.07 | -10000 | 0 | -0.27 | 12 | 12 |
EntrezGene:2778 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
vasopressin secretion | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
G-protein coupled receptor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ChemicalAbstracts:86-01-1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
glutamate secretion | 0.004 | 0.018 | 0.072 | 12 | -10000 | 0 | 12 |
GNAL | -0.019 | 0.12 | -10000 | 0 | -0.49 | 12 | 12 |
GNG2 | 0.001 | 0.078 | -10000 | 0 | -0.52 | 4 | 4 |
CRH | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:cortisol | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.008 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK11 | 0.005 | 0.031 | -10000 | 0 | -0.28 | 2 | 2 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Condensin I complex | 0.032 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
STMN1 | 0.022 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
Aurora B/RasGAP/Survivin | 0.018 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
Chromosomal passenger complex/Cul3 protein complex | -0.011 | 0.082 | -9999 | 0 | -10000 | 0 | 0 |
BIRC5 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
DES | -0.14 | 0.21 | -9999 | 0 | -0.55 | 40 | 40 |
Aurora C/Aurora B/INCENP | 0.016 | 0.065 | -9999 | 0 | -0.36 | 5 | 5 |
Aurora B/TACC1 | 0.005 | 0.053 | -9999 | 0 | -0.4 | 3 | 3 |
Aurora B/PP2A | 0.021 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CBX5 | 0.015 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mitotic metaphase/anaphase transition | 0 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
NDC80 | 0.022 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
Cul3 protein complex | -0.057 | 0.15 | -9999 | 0 | -0.39 | 21 | 21 |
KIF2C | 0.02 | 0.035 | -9999 | 0 | -0.46 | 1 | 1 |
PEBP1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
KIF20A | 0.008 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora B/RasGAP | 0.021 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
SEPT1 | -0.015 | 0.12 | -9999 | 0 | -0.56 | 9 | 9 |
SMC2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMC4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NSUN2/NPM1/Nucleolin | 0.029 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
PSMA3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition of mitotic cell cycle | 0 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
H3F3B | 0.017 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
AURKB | 0.016 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
AURKC | -0.007 | 0.11 | -9999 | 0 | -0.6 | 6 | 6 |
CDCA8 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
cytokinesis | -0.011 | 0.027 | -9999 | 0 | -0.36 | 1 | 1 |
Aurora B/Septin1 | 0.009 | 0.072 | -9999 | 0 | -0.33 | 3 | 3 |
AURKA | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
INCENP | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
KLHL13 | -0.12 | 0.23 | -9999 | 0 | -0.51 | 48 | 48 |
BUB1 | 0.011 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
hSgo1/Aurora B/Survivin | 0.017 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
EVI5 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GTP | -0.002 | 0.03 | -9999 | 0 | -0.41 | 1 | 1 |
SGOL1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CENPA | 0.027 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
NCAPG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora B/HC8 Proteasome | 0.021 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
NCAPD2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora B/PP1-gamma | 0.021 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCAPH | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NPM1 | 0.018 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
RASA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KLHL9 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mitotic prometaphase | 0.001 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.021 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
PPP1CC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Centraspindlin | -0.002 | 0.033 | -9999 | 0 | -0.45 | 1 | 1 |
RhoA/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NSUN2 | 0.018 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
MYLK | -0.009 | 0.084 | -9999 | 0 | -0.37 | 7 | 7 |
KIF23 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
VIM | 0.016 | 0.048 | -9999 | 0 | -0.35 | 3 | 3 |
RACGAP1 | 0.012 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mitosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCL | 0.018 | 0.003 | -9999 | 0 | -10000 | 0 | 0 |
Chromosomal passenger complex | 0.031 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
Chromosomal passenger complex/EVI5 | 0.034 | 0.037 | -9999 | 0 | -10000 | 0 | 0 |
TACC1 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
PPP2R5D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CUL3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to DNA damage stimulus | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
FBXW11 | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA/I kappa B alpha | 0.064 | 0.042 | -9999 | 0 | -10000 | 0 | 0 |
ERC1 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RIP2/NOD2 | -0.01 | 0.11 | -9999 | 0 | -0.42 | 12 | 12 |
NFKBIA | 0.04 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BIRC2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKBKB | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RIPK2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKBKG | -0.011 | 0.046 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex/A20 | -0.021 | 0.073 | -9999 | 0 | -0.49 | 2 | 2 |
NEMO/A20/RIP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XPO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NEMO/ATM | 0.033 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
tumor necrosis factor receptor activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Exportin 1/RanGTP | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex/ELKS | -0.01 | 0.043 | -9999 | 0 | -0.35 | 1 | 1 |
BCL10/MALT1/TRAF6 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NOD2 | -0.025 | 0.14 | -9999 | 0 | -0.58 | 12 | 12 |
NFKB1 | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RELA | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MALT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cIAP1/UbcH5C | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ATM | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNF/TNFR1A | -0.003 | 0.095 | -9999 | 0 | -0.43 | 9 | 9 |
TRAF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCA | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
CHUK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE2D3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNF | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
NF kappa B1 p50/RelA | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCL10 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.04 | 0 | -9999 | 0 | -10000 | 0 | 0 |
beta TrCP1/SCF ubiquitin ligase complex | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex | 0.038 | 0.053 | -9999 | 0 | -10000 | 0 | 0 |
CYLD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex/PKC alpha | -0.012 | 0.047 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BARD1/CSTF1 | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
ATM | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
UBE2D3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKDC | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
ATR | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
UBE2L3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FANCD2 | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
protein ubiquitination | -0.004 | 0.035 | -10000 | 0 | -0.32 | 2 | 2 |
XRCC5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
XRCC6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
M/R/N Complex | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MRE11A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNA-PK | 0.022 | 0.03 | -10000 | 0 | -0.39 | 1 | 1 |
FA complex/FANCD2/Ubiquitin | 0.044 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
FANCF | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
BRCA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CCNE1 | 0.01 | 0.031 | -10000 | 0 | -0.42 | 1 | 1 |
CDK2/Cyclin E1 | 0.016 | 0.022 | -10000 | 0 | -0.28 | 1 | 1 |
FANCG | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BRCA1/BACH1/BARD1 | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
FANCE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FANCC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NBN | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FANCA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNA repair | 0.06 | 0.038 | -10000 | 0 | -10000 | 0 | 0 |
BRCA1/BARD1/ubiquitin | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
BARD1/DNA-PK | 0.025 | 0.048 | -10000 | 0 | -0.35 | 3 | 3 |
FANCL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mRNA polyadenylation | -0.013 | 0.049 | 0.46 | 2 | -10000 | 0 | 2 |
BRCA1/BARD1/CTIP/M/R/N Complex | 0.033 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
BRCA1/BACH1/BARD1/TopBP1 | 0.02 | 0.042 | -10000 | 0 | -0.39 | 2 | 2 |
BRCA1/BARD1/P53 | 0.001 | 0.1 | -10000 | 0 | -0.35 | 15 | 15 |
BARD1/CSTF1/BRCA1 | 0.02 | 0.042 | -10000 | 0 | -0.39 | 2 | 2 |
BRCA1/BACH1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BARD1 | 0.005 | 0.066 | -10000 | 0 | -0.64 | 2 | 2 |
PCNA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BRCA1/BARD1/UbcH5C | 0.02 | 0.042 | -10000 | 0 | -0.39 | 2 | 2 |
BRCA1/BARD1/UbcH7 | 0.02 | 0.042 | -10000 | 0 | -0.39 | 2 | 2 |
BRCA1/BARD1/RAD51/PCNA | 0.027 | 0.039 | -10000 | 0 | -0.35 | 2 | 2 |
BARD1/DNA-PK/P53 | 0.006 | 0.11 | -10000 | 0 | -0.35 | 15 | 15 |
BRCA1/BARD1/Ubiquitin | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
BRCA1/BARD1/CTIP | 0.026 | 0.039 | -10000 | 0 | -0.35 | 2 | 2 |
FA complex | 0.033 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
BARD1/EWS | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
RBBP8 | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TP53 | -0.032 | 0.16 | -10000 | 0 | -0.64 | 13 | 13 |
TOPBP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
G1/S transition of mitotic cell cycle | 0 | 0.1 | 0.35 | 15 | -10000 | 0 | 15 |
BRCA1/BARD1 | 0.031 | 0.04 | -10000 | 0 | -0.33 | 2 | 2 |
CSTF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BARD1/EWS-Fli1 | 0.004 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
CDK2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
UniProt:Q9BZD1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAD51 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAD50 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BRCA1/BARD1/DNA-directed RNA polymerase II holoenzyme | 0.013 | 0.049 | -10000 | 0 | -0.47 | 2 | 2 |
EWSR1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Aurora A/GADD45A | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BIRC5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NFKBIA | 0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CPEB1 | -0.05 | 0.15 | -9999 | 0 | -0.44 | 25 | 25 |
AKT1 | 0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NDEL1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/BRCA1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NDEL1/TACC3 | 0.028 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GADD45A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GSK3B | 0.011 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PAK1/Aurora A | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MDM2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JUB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TPX2 | 0.018 | 0.035 | -9999 | 0 | -0.47 | 1 | 1 |
TP53 | 0.002 | 0.088 | -9999 | 0 | -0.32 | 13 | 13 |
DLG7 | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AURKAIP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARHGEF7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2 phase of mitotic cell cycle | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/NDEL1/TACC3 | 0.029 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition of mitotic cell cycle | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AURKA | 0.021 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AURKB | 0.014 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC25B | 0.026 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition checkpoint | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mRNA polyadenylation | -0.029 | 0.077 | -9999 | 0 | -0.36 | 3 | 3 |
Aurora A/CPEB | -0.029 | 0.078 | -9999 | 0 | -0.36 | 3 | 3 |
Aurora A/TACC1/TRAP/chTOG | 0.03 | 0.045 | -9999 | 0 | -0.33 | 3 | 3 |
BRCA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
centrosome duplication | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of centrosome cycle | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
spindle assembly | 0.029 | 0.044 | -9999 | 0 | -0.32 | 3 | 3 |
TDRD7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/RasGAP/Survivin | 0.033 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CENPA | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/PP2A | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
meiosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
protein catabolic process | 0.021 | 0.037 | -9999 | 0 | -10000 | 0 | 0 |
negative regulation of DNA binding | 0.002 | 0.088 | -9999 | 0 | -0.32 | 13 | 13 |
prophase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GIT1/beta-PIX | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RASA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ajuba/Aurora A | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mitotic prometaphase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.021 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TACC1 | 0.002 | 0.08 | -9999 | 0 | -0.64 | 3 | 3 |
TACC3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/Antizyme1 | 0.029 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/RasGAP | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
OAZ1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mitosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKACA | 0.011 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GIT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GIT1/beta-PIX/PAK1 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Importin alpha/Importin beta/TPX2 | 0.018 | 0.035 | -9999 | 0 | -0.47 | 1 | 1 |
PPP2R5D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/TPX2 | 0.028 | 0.028 | -9999 | 0 | -0.35 | 1 | 1 |
PAK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CKAP5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
INCENP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora C/Aurora B/INCENP | 0.012 | 0.063 | -9999 | 0 | -0.36 | 5 | 5 |
metaphase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mitosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
H3F3B | -0.003 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
AURKB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AURKC | -0.007 | 0.11 | -9999 | 0 | -0.6 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | 0.057 | 0.063 | -9999 | 0 | -10000 | 0 | 0 |
CRKL | 0.036 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
mol:DAG | 0.04 | 0.038 | -9999 | 0 | -0.33 | 1 | 1 |
HRAS | 0.054 | 0.031 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.029 | 0.027 | -9999 | 0 | -0.33 | 1 | 1 |
RAP1A | 0.036 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
GAB1 | 0.036 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.029 | 0.027 | -9999 | 0 | -0.33 | 1 | 1 |
EPO | 0.01 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
PLCG1 | 0.041 | 0.039 | -9999 | 0 | -0.34 | 1 | 1 |
EPOR/TRPC2/IP3 Receptors | 0.011 | 0.046 | -9999 | 0 | -0.63 | 1 | 1 |
RAPGEF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EPO/EPOR (dimer)/SOCS3 | 0.02 | 0.047 | -9999 | 0 | -0.39 | 2 | 2 |
GAB1/SHC/GRB2/SOS1 | -0.003 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
EPO/EPOR (dimer) | 0.017 | 0.035 | -9999 | 0 | -0.46 | 1 | 1 |
IRS2 | 0.031 | 0.054 | -9999 | 0 | -0.35 | 2 | 2 |
STAT1 | 0.045 | 0.058 | -9999 | 0 | -10000 | 0 | 0 |
STAT5B | 0.044 | 0.044 | -9999 | 0 | -0.34 | 1 | 1 |
cell proliferation | 0.034 | 0.025 | -9999 | 0 | -10000 | 0 | 0 |
GAB1/SHIP/PIK3R1/SHP2/SHC | -0.012 | 0.05 | -9999 | 0 | -10000 | 0 | 0 |
TEC | 0.036 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
SOCS3 | 0.006 | 0.056 | -9999 | 0 | -0.52 | 2 | 2 |
STAT1 (dimer) | 0.045 | 0.057 | -9999 | 0 | -10000 | 0 | 0 |
JAK2 | 0.007 | 0.053 | -9999 | 0 | -0.41 | 3 | 3 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EPO/EPOR (dimer)/JAK2 | 0.042 | 0.039 | -9999 | 0 | -0.3 | 1 | 1 |
EPO/EPOR | 0.017 | 0.035 | -9999 | 0 | -0.46 | 1 | 1 |
LYN | 0.013 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
TEC/VAV2 | 0.032 | 0.067 | -9999 | 0 | -10000 | 0 | 0 |
elevation of cytosolic calcium ion concentration | 0.011 | 0.046 | -9999 | 0 | -0.63 | 1 | 1 |
SHC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EPO/EPOR (dimer)/LYN | 0.029 | 0.03 | -9999 | 0 | -0.37 | 1 | 1 |
mol:IP3 | 0.04 | 0.038 | -9999 | 0 | -0.33 | 1 | 1 |
PI3K regualtory subunit polypeptide 1/IRS2/SHIP | 0.029 | 0.078 | -9999 | 0 | -0.36 | 1 | 1 |
SH2B3 | 0.013 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.029 | 0.027 | -9999 | 0 | -0.33 | 1 | 1 |
EPO/EPOR (dimer)/JAK2/SOCS3 | -0.005 | 0.027 | -9999 | 0 | -0.24 | 1 | 1 |
PTPN6 | 0.03 | 0.036 | -9999 | 0 | -0.3 | 1 | 1 |
TEC/VAV2/GRB2 | 0.037 | 0.065 | -9999 | 0 | -10000 | 0 | 0 |
EPOR | 0.011 | 0.047 | -9999 | 0 | -0.63 | 1 | 1 |
INPP5D | -0.012 | 0.12 | -9999 | 0 | -0.64 | 7 | 7 |
mol:GDP | -0.004 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
SOS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLCG2 | -0.036 | 0.16 | -9999 | 0 | -0.57 | 16 | 16 |
CRKL/CBL/C3G | 0.047 | 0.033 | -9999 | 0 | -10000 | 0 | 0 |
VAV2 | 0.025 | 0.069 | -9999 | 0 | -0.3 | 6 | 6 |
CBL | 0.036 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
SHC/Grb2/SOS1 | -0.004 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
STAT5A | 0.044 | 0.044 | -9999 | 0 | -10000 | 0 | 0 |
GRB2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT5 (dimer) | 0.058 | 0.056 | -9999 | 0 | -10000 | 0 | 0 |
LYN/PLCgamma2 | -0.017 | 0.12 | -9999 | 0 | -0.41 | 16 | 16 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BTK | 0.002 | 0.1 | -9999 | 0 | -0.31 | 15 | 15 |
BCL2 | 0.045 | 0.13 | -9999 | 0 | -0.89 | 3 | 3 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
GBL | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MKNK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:PIP3 | -0.007 | 0.053 | 0.29 | 1 | -0.3 | 5 | 6 |
FRAP1 | 0.013 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
AKT1 | 0.019 | 0.046 | 0.22 | 1 | -0.24 | 5 | 6 |
INSR | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Insulin Receptor/Insulin | 0.007 | 0.018 | -10000 | 0 | -0.24 | 1 | 1 |
mol:GTP | -0.005 | 0.03 | -10000 | 0 | -10000 | 0 | 0 |
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA/eIF3/40s Ribosomal subunit | -0.001 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
TSC2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RHEB/GDP | -0.004 | 0.025 | -10000 | 0 | -10000 | 0 | 0 |
TSC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Insulin Receptor/IRS1 | 0.003 | 0.066 | -10000 | 0 | -0.36 | 6 | 6 |
eIF4E/eIF4G1/eIF4A1/eIF4B/RNA | -0.002 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EIF3A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RPS6KB1 | 0.022 | 0.025 | 0.18 | 1 | -10000 | 0 | 1 |
MAP3K5 | 0.009 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
apoptosis | 0.009 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
mol:LY294002 | 0 | 0 | -10000 | 0 | -0.002 | 6 | 6 |
EIF4B | 0.027 | 0.023 | -10000 | 0 | -10000 | 0 | 0 |
40S S6 ribosomal protein /40s Ribosomal subunit/eIF3 | 0.027 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
eIF4E/eIF4G1/eIF4A1 | 0 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
KIAA1303 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PI3K | 0.012 | 0.06 | -10000 | 0 | -0.32 | 6 | 6 |
mTOR/RHEB/GTP/Raptor/GBL | 0.026 | 0.018 | 0.16 | 1 | -10000 | 0 | 1 |
FKBP1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RHEB/GTP | -0.004 | 0.024 | -10000 | 0 | -10000 | 0 | 0 |
mol:Amino Acids | 0 | 0 | -10000 | 0 | -0.002 | 6 | 6 |
FKBP12/Rapamycin | 0.009 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
PDPK1 | -0.006 | 0.047 | 0.24 | 1 | -0.27 | 5 | 6 |
EIF4E | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ASK1/PP5C | 0.02 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
mTOR/RHEB/GTP/Raptor/GBL/eIF4E | 0.015 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
TSC1/TSC2 | 0.029 | 0.037 | -10000 | 0 | -10000 | 0 | 0 |
tumor necrosis factor receptor activity | 0 | 0 | 0.002 | 6 | -10000 | 0 | 6 |
RPS6 | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
PPP5C | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EIF4G1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IRS1 | -0.005 | 0.07 | -10000 | 0 | -0.39 | 6 | 6 |
INS | -0.002 | 0.03 | -10000 | 0 | -0.42 | 1 | 1 |
PTEN | 0.005 | 0.065 | -10000 | 0 | -0.63 | 2 | 2 |
PDK2 | -0.006 | 0.047 | 0.24 | 1 | -0.27 | 5 | 6 |
EIF4EBP1 | 0.011 | 0.001 | -10000 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PPP2R5D | 0.018 | 0.011 | -10000 | 0 | -10000 | 0 | 0 |
peptide biosynthetic process | 0.014 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
RHEB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EIF4A1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Rapamycin | 0 | 0 | 0.003 | 2 | -10000 | 0 | 2 |
EEF2 | 0.014 | 0.016 | -10000 | 0 | -10000 | 0 | 0 |
eIF4E/4E-BP1 | 0.017 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TNFSF10 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of NF-kappaB transcription factor activity | 0.013 | 0.037 | -9999 | 0 | -0.28 | 3 | 3 |
MAP2K4 | 0.04 | 0.025 | -9999 | 0 | -0.31 | 1 | 1 |
IKBKB | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
TNFRSF10B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF10A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMPD1 | 0.017 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
IKBKG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF10D | 0.005 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
TRAIL/TRAILR2 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR3 | -0.006 | 0.087 | -9999 | 0 | -0.31 | 14 | 14 |
TRAIL/TRAILR1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR4 | 0.013 | 0.037 | -9999 | 0 | -0.28 | 3 | 3 |
TRAIL/TRAILR1/DAP3/GTP | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKK complex | -0.001 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
RIPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to oxidative stress | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAP3/GTP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAP3K1 | 0.037 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAILR4 (trimer) | 0.005 | 0.053 | -9999 | 0 | -0.42 | 3 | 3 |
TRADD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAILR1 (trimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR1/FADD/TRADD/RIP/TRAF2 | 0.033 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CFLAR | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR1/FADD/TRADD/RIP | 0.036 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:ceramide | 0.017 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
FADD | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.045 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
TRAF2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAILR3 (trimer) | -0.021 | 0.12 | -9999 | 0 | -0.45 | 14 | 14 |
CHUK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR1/FADD | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DAP3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP10 | 0.003 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
JNK cascade | 0.013 | 0.037 | -9999 | 0 | -0.28 | 3 | 3 |
TRAIL (trimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF10C | -0.022 | 0.12 | -9999 | 0 | -0.45 | 14 | 14 |
TRAIL/TRAILR1/DAP3/GTP/FADD | 0.028 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR2/FADD | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cell death | 0.017 | 0.013 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR2/FADD/TRADD/RIP/TRAF2 | 0.033 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAILR2 (trimer) | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CASP8 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
negative regulation of caspase activity | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAIL/TRAILR2/FADD/TRADD/RIP | 0.036 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MAP4K4 | 0.03 | 0.07 | -10000 | 0 | -0.48 | 2 | 2 |
BAG4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BAD | 0.023 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
NFKBIA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BIRC3 | -0.016 | 0.12 | -10000 | 0 | -0.48 | 11 | 11 |
BAX | 0.023 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
EnzymeConsortium:3.1.4.12 | 0.01 | 0.019 | -10000 | 0 | -0.11 | 2 | 2 |
IKBKB | 0.034 | 0.068 | -10000 | 0 | -0.45 | 2 | 2 |
MAP2K2 | 0.033 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K1 | 0.033 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
SMPD1 | 0.015 | 0.021 | -10000 | 0 | -0.13 | 1 | 1 |
GO:0005551 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FADD/Caspase 8 | 0.036 | 0.069 | -10000 | 0 | -0.46 | 2 | 2 |
MAP2K4 | 0.027 | 0.035 | -10000 | 0 | -0.29 | 1 | 1 |
protein ubiquitination | 0.036 | 0.068 | -10000 | 0 | -0.46 | 2 | 2 |
EnzymeConsortium:2.7.1.37 | 0.037 | 0.031 | -10000 | 0 | -10000 | 0 | 0 |
response to UV | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAF1 | 0.029 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
CRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:ceramide | 0.017 | 0.027 | -10000 | 0 | -0.15 | 2 | 2 |
I-kappa-B-alpha/RELA/p50/ubiquitin | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K1 | 0.023 | 0.027 | -10000 | 0 | -10000 | 0 | 0 |
TRADD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RELA/p50 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK3 | 0.035 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.035 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
p50/RELA/I-kappa-B-alpha | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FADD | 0.03 | 0.07 | -10000 | 0 | -0.48 | 2 | 2 |
KSR1 | 0.024 | 0.028 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.032 | 0.033 | -10000 | 0 | -0.26 | 1 | 1 |
TRAF2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to radiation | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CHUK | 0.035 | 0.067 | -10000 | 0 | -0.45 | 2 | 2 |
TNF R/SODD | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TNF | -0.016 | 0.13 | -10000 | 0 | -0.59 | 9 | 9 |
CYCS | 0.026 | 0.03 | 0.14 | 3 | -10000 | 0 | 3 |
IKBKG | 0.035 | 0.067 | -10000 | 0 | -0.45 | 2 | 2 |
TNF/TNF R/TRADD/MADD/cIAP/RIP/TRAF2/RAIDD | 0.024 | 0.074 | -10000 | 0 | -0.51 | 2 | 2 |
RELA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RIPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AIFM1 | 0.026 | 0.03 | 0.14 | 3 | -10000 | 0 | 3 |
TNF/TNF R/SODD | 0.007 | 0.082 | -10000 | 0 | -0.39 | 7 | 7 |
TNFRSF1A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to heat | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CASP8 | 0.024 | 0.019 | -10000 | 0 | -10000 | 0 | 0 |
NSMAF | 0.03 | 0.07 | -10000 | 0 | -0.47 | 2 | 2 |
response to hydrogen peroxide | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BCL2 | -0.005 | 0.095 | -10000 | 0 | -0.52 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
MMP14 | -0.004 | 0.046 | -10000 | 0 | -10000 | 0 | 0 |
oxygen homeostasis | 0.006 | 0.015 | -10000 | 0 | -10000 | 0 | 0 |
TCEB2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TCEB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VHL/Elongin B/Elongin C/HIF2A | -0.01 | 0.041 | -10000 | 0 | -10000 | 0 | 0 |
EPO | 0.083 | 0.19 | -10000 | 0 | -10000 | 0 | 0 |
FIH (dimer) | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
APEX1 | 0.017 | 0.015 | -10000 | 0 | -10000 | 0 | 0 |
SERPINE1 | 0.045 | 0.26 | -10000 | 0 | -0.74 | 7 | 7 |
FLT1 | -0.03 | 0.18 | -10000 | 0 | -1 | 6 | 6 |
ADORA2A | 0.073 | 0.2 | -10000 | 0 | -0.6 | 1 | 1 |
germ cell development | 0.059 | 0.24 | -10000 | 0 | -0.66 | 6 | 6 |
SLC11A2 | 0.078 | 0.2 | -10000 | 0 | -0.62 | 1 | 1 |
BHLHE40 | 0.078 | 0.2 | -10000 | 0 | -0.62 | 1 | 1 |
HIF1AN | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
HIF2A/ARNT/SIRT1 | 0.03 | 0.12 | -10000 | 0 | -10000 | 0 | 0 |
ETS1 | 0.007 | 0.1 | -10000 | 0 | -0.56 | 6 | 6 |
CITED2 | 0 | 0.017 | -10000 | 0 | -10000 | 0 | 0 |
KDR | -0.025 | 0.18 | -10000 | 0 | -1.2 | 4 | 4 |
PGK1 | 0.078 | 0.2 | -10000 | 0 | -0.62 | 1 | 1 |
SIRT1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to hypoxia | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HIF2A/ARNT | 0.09 | 0.23 | -10000 | 0 | -0.64 | 3 | 3 |
EPAS1 | 0.053 | 0.097 | -10000 | 0 | -0.34 | 1 | 1 |
SP1 | 0.019 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
ABCG2 | 0.043 | 0.26 | -10000 | 0 | -0.77 | 7 | 7 |
EFNA1 | 0.077 | 0.2 | -10000 | 0 | -0.62 | 1 | 1 |
FXN | 0.075 | 0.2 | -10000 | 0 | -0.6 | 1 | 1 |
POU5F1 | 0.058 | 0.24 | -10000 | 0 | -0.69 | 6 | 6 |
neuron apoptosis | -0.088 | 0.22 | 0.62 | 3 | -10000 | 0 | 3 |
EP300 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
EGLN3 | -0.001 | 0.1 | -10000 | 0 | -0.5 | 7 | 7 |
EGLN2 | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
EGLN1 | 0.018 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
VHL/Elongin B/Elongin C | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
VHL | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARNT | 0.017 | 0.015 | -10000 | 0 | -10000 | 0 | 0 |
SLC2A1 | 0.071 | 0.21 | -10000 | 0 | -0.64 | 3 | 3 |
TWIST1 | 0.039 | 0.27 | -10000 | 0 | -0.72 | 12 | 12 |
ELK1 | 0.019 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HIF2A/ARNT/Cbp/p300 | -0.025 | 0.07 | -10000 | 0 | -10000 | 0 | 0 |
VEGFA | 0.078 | 0.2 | -10000 | 0 | -0.62 | 1 | 1 |
CREBBP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
NF kappa B/RelA | -0.016 | 0.072 | -9999 | 0 | -0.37 | 7 | 7 |
Ran/GTP/Exportin 1/HDAC1 | -0.001 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA/I kappa B alpha | 0.027 | 0.072 | -9999 | 0 | -0.33 | 7 | 7 |
SUMO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ZFPM1 | 0.002 | 0.07 | -9999 | 0 | -0.47 | 4 | 4 |
NPC/RanGAP1/SUMO1/Ubc9 | 0.019 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
FKBP3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Histones | 0.033 | 0.04 | -9999 | 0 | -10000 | 0 | 0 |
YY1/LSF | 0.023 | 0.041 | -9999 | 0 | -0.3 | 3 | 3 |
SMG5 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
I kappa B alpha/HDAC3 | 0.017 | 0.062 | -9999 | 0 | -0.29 | 7 | 7 |
I kappa B alpha/HDAC1 | 0.02 | 0.044 | -9999 | 0 | -10000 | 0 | 0 |
SAP18 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
RELA | 0.021 | 0.059 | -9999 | 0 | -0.26 | 7 | 7 |
HDAC1/Smad7 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RANGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC3/TR2 | 0.02 | 0.044 | -9999 | 0 | -10000 | 0 | 0 |
NuRD/MBD3 Complex | 0.042 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA | 0.024 | 0.055 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:23225 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATA2 | -0.017 | 0.13 | -9999 | 0 | -0.55 | 10 | 10 |
GATA1 | 0.008 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
Mad/Max | 0.015 | 0.031 | -9999 | 0 | -0.28 | 2 | 2 |
NuRD/MBD3 Complex/GATA1/Fog1 | 0.048 | 0.021 | -9999 | 0 | -10000 | 0 | 0 |
RBBP7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NPC | 0.006 | 0.015 | -9999 | 0 | -0.21 | 1 | 1 |
RBBP4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAX | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:9972 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FBXW11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NFKBIA | 0.015 | 0.049 | -9999 | 0 | -10000 | 0 | 0 |
KAT2B | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SIN3/HDAC complex | 0.038 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
SIN3 complex | 0.03 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
SMURF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CHD3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SAP30 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:23636 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCOR1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
YY1/HDAC3 | 0.028 | 0.047 | -9999 | 0 | -10000 | 0 | 0 |
YY1/HDAC2 | 0.025 | 0.029 | -9999 | 0 | -0.25 | 2 | 2 |
YY1/HDAC1 | 0.025 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
NuRD/MBD2 Complex (MeCP1) | 0.042 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPARG | 0.009 | 0.092 | -9999 | 0 | -0.34 | 12 | 12 |
HDAC8/hEST1B | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE2I | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
beta TrCP1/SCF ubiquitin ligase complex | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNFRSF1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC3/SMRT (N-CoR2) | 0.018 | 0.051 | -9999 | 0 | -0.35 | 1 | 1 |
MBD3L2 | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
ubiquitin-dependent protein catabolic process | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CREBBP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NuRD/MBD3/MBD3L2 Complex | 0.046 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
HDAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
HDAC3 | 0.015 | 0.049 | -9999 | 0 | -10000 | 0 | 0 |
HDAC2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YY1 | 0.024 | 0.033 | -9999 | 0 | -0.3 | 2 | 2 |
HDAC8 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMAD7 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCOR2 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
MXD1 | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
STAT3 | 0.021 | 0.028 | -9999 | 0 | -0.36 | 1 | 1 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:8021 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RANBP2 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
YY1/LSF/HDAC1 | 0.029 | 0.038 | -9999 | 0 | -0.34 | 1 | 1 |
YY1/SAP30/HDAC1 | 0.031 | 0.026 | -9999 | 0 | -10000 | 0 | 0 |
EP300 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
STAT3 (dimer non-phopshorylated) | 0.021 | 0.028 | -9999 | 0 | -0.36 | 1 | 1 |
proteasomal ubiquitin-dependent protein catabolic process | 0.015 | 0.049 | -9999 | 0 | -10000 | 0 | 0 |
histone deacetylation | 0.042 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAT3 (dimer non-phopshorylated)/HDAC3 | 0.027 | 0.045 | -9999 | 0 | -10000 | 0 | 0 |
nuclear export | -0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATAD2B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATAD2A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATA2/HDAC3 | 0.004 | 0.092 | -9999 | 0 | -0.38 | 8 | 8 |
GATA1/HDAC1 | 0.015 | 0.004 | -9999 | 0 | -10000 | 0 | 0 |
GATA1/HDAC3 | 0.01 | 0.044 | -9999 | 0 | -10000 | 0 | 0 |
CHD4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNF-alpha/TNFR1A | -0.003 | 0.095 | -9999 | 0 | -0.43 | 9 | 9 |
SIN3/HDAC complex/Mad/Max | 0.041 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
NuRD Complex | 0.05 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of chromatin silencing | -0.006 | 0.031 | -9999 | 0 | -10000 | 0 | 0 |
SIN3B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MTA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SIN3A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XPO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SUMO1/HDAC1 | 0.027 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
HDAC complex | 0.031 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GATA1/Fog1 | 0.007 | 0.052 | -9999 | 0 | -0.34 | 4 | 4 |
FKBP25/HDAC1/HDAC2 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TNF | -0.016 | 0.13 | -9999 | 0 | -0.59 | 9 | 9 |
negative regulation of cell growth | 0.041 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
NuRD/MBD2/PRMT5 Complex | 0.042 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1 | 0.029 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B/RelA/I kappa B alpha | 0.021 | 0.075 | -9999 | 0 | -0.35 | 7 | 7 |
SIN3/HDAC complex/NCoR1 | 0.039 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
TFCP2 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
NR2C1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MBD3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MBD2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
CTTN | 0.035 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
KLHL20 | -0.019 | 0.048 | -9999 | 0 | -0.23 | 6 | 6 |
CYFIP2 | -0.002 | 0.092 | -9999 | 0 | -0.64 | 4 | 4 |
Rac1/GDP | 0.052 | 0.03 | -9999 | 0 | -10000 | 0 | 0 |
ENAH | 0.028 | 0.052 | -9999 | 0 | -10000 | 0 | 0 |
AP1M1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAP1B | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAP1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42/GTP | -0.002 | 0.015 | -9999 | 0 | -10000 | 0 | 0 |
ABI1/Sra1/Nap1 | -0.014 | 0.037 | -9999 | 0 | -0.2 | 3 | 3 |
E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin | 0.01 | 0.084 | -9999 | 0 | -0.36 | 8 | 8 |
RAPGEF1 | 0.045 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
CTNND1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of calcium-dependent cell-cell adhesion | 0.029 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
CRK | 0.041 | 0.021 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/gamma catenin/alpha catenin | 0.022 | 0.03 | -9999 | 0 | -0.39 | 1 | 1 |
alphaE/beta7 Integrin | -0.009 | 0.11 | -9999 | 0 | -0.41 | 12 | 12 |
IQGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCKAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rap1/GTP/I-afadin | 0.019 | 0.039 | -9999 | 0 | -0.36 | 2 | 2 |
DLG1 | 0.035 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
ChemicalAbstracts:7440-70-2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | -0.001 | 0.011 | -9999 | 0 | -10000 | 0 | 0 |
MLLT4 | 0.005 | 0.066 | -9999 | 0 | -0.64 | 2 | 2 |
ARF6/GTP/NME1/Tiam1 | -0.027 | 0.12 | -9999 | 0 | -0.36 | 16 | 16 |
PI3K | -0.002 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
ARF6 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/gamma catenin | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TIAM1 | -0.075 | 0.2 | -9999 | 0 | -0.53 | 31 | 31 |
E-cadherin(dimer)/Ca2+ | 0.027 | 0.026 | -9999 | 0 | -0.33 | 1 | 1 |
AKT1 | -0.001 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDH1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GDP | 0.052 | 0.03 | -9999 | 0 | -10000 | 0 | 0 |
actin cytoskeleton organization | 0.019 | 0.05 | -9999 | 0 | -0.19 | 2 | 2 |
CDC42/GDP | 0.052 | 0.03 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin | 0.021 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
ITGB7 | -0.023 | 0.14 | -9999 | 0 | -0.54 | 12 | 12 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/beta catenin/alpha catenin/p120 catenin | 0.029 | 0.028 | -9999 | 0 | -0.35 | 1 | 1 |
E-cadherin/Ca2+/beta catenin/alpha catenin | 0.02 | 0.026 | -9999 | 0 | -0.34 | 1 | 1 |
mol:GDP | 0.049 | 0.033 | -9999 | 0 | -10000 | 0 | 0 |
CDC42/GTP/IQGAP1 | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
JUP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
p120 catenin/RhoA/GDP | -0.003 | 0.016 | -9999 | 0 | -10000 | 0 | 0 |
RAC1/GTP/IQGAP1 | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIP5K1C/AP1M1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC42 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTNNA1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
positive regulation of S phase of mitotic cell cycle | 0.017 | 0.034 | -9999 | 0 | -10000 | 0 | 0 |
NME1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
clathrin coat assembly | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TJP1 | 0.035 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
regulation of cell-cell adhesion | -0.002 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
WASF2 | -0.007 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
Rap1/GTP | -0.002 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin | 0.014 | 0.083 | -9999 | 0 | -0.33 | 9 | 9 |
CCND1 | 0.02 | 0.04 | -9999 | 0 | -10000 | 0 | 0 |
VAV2 | 0.022 | 0.13 | -9999 | 0 | -0.69 | 6 | 6 |
RAP1/GDP | 0.038 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
adherens junction assembly | 0.035 | 0.021 | -9999 | 0 | -10000 | 0 | 0 |
homophilic cell adhesion | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ABI1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIP5K1C | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of heterotypic cell-cell adhesion | 0.02 | 0.08 | -9999 | 0 | -0.36 | 1 | 1 |
E-cadherin/beta catenin | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.035 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.03 | 0.078 | -9999 | 0 | -0.38 | 6 | 6 |
E-cadherin/beta catenin/alpha catenin | 0.022 | 0.03 | -9999 | 0 | -0.39 | 1 | 1 |
ITGAE | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin | -0.002 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
SLC2A4 | -0.016 | 0.12 | -10000 | 0 | -0.48 | 11 | 11 |
CLTC | 0.029 | 0 | -10000 | 0 | -10000 | 0 | 0 |
calcium ion-dependent exocytosis | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Dynamin 2/GTP | 0.022 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EXOC4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CD59 | 0.026 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CPE | -0.062 | 0.15 | -10000 | 0 | -0.34 | 42 | 42 |
CTNNB1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
membrane fusion | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CTNND1 | 0.028 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DNM2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0.029 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TSHR | -0.001 | 0.061 | -10000 | 0 | -0.24 | 12 | 12 |
INS | 0.01 | 0.007 | -10000 | 0 | -10000 | 0 | 0 |
BIN1 | 0.002 | 0.08 | -10000 | 0 | -0.64 | 3 | 3 |
mol:Choline | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
growth hormone secretagogue receptor activity | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:GDP | 0.017 | 0 | -10000 | 0 | -10000 | 0 | 0 |
membrane depolarization | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0.022 | 0 | -10000 | 0 | -10000 | 0 | 0 |
JUP | 0.026 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ASAP2/amphiphysin II | 0.015 | 0.055 | -10000 | 0 | -0.36 | 4 | 4 |
ARF6/GTP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDH1 | 0.026 | 0 | -10000 | 0 | -10000 | 0 | 0 |
clathrin-independent pinocytosis | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK8IP3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of endocytosis | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EXOC2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
substrate adhesion-dependent cell spreading | 0.038 | 0 | -10000 | 0 | -10000 | 0 | 0 |
insulin receptor binding | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SPAG9 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
regulation of calcium-dependent cell-cell adhesion | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
positive regulation of phagocytosis | 0.017 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GTP/JIP3 | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ACAP1 | 0.012 | 0.034 | -10000 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CHRM2 | -0.024 | 0.088 | -10000 | 0 | -10000 | 0 | 0 |
clathrin heavy chain/ACAP1 | 0.031 | 0.008 | -10000 | 0 | -10000 | 0 | 0 |
JIP4/KLC1 | 0.021 | 0.028 | -10000 | 0 | -0.36 | 1 | 1 |
EXOC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
exocyst | 0.039 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RALA/GTP | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GTP/ARF6/GTP/JIP4/Dynactin Complex | 0.014 | 0.03 | -10000 | 0 | -0.4 | 1 | 1 |
receptor recycling | 0.009 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CTNNA1 | 0.026 | 0.026 | -10000 | 0 | -0.34 | 1 | 1 |
NME1 | 0.017 | 0 | -10000 | 0 | -10000 | 0 | 0 |
clathrin coat assembly | 0.029 | 0 | -10000 | 0 | -10000 | 0 | 0 |
IL2RA | 0 | 0.07 | -10000 | 0 | -10000 | 0 | 0 |
VAMP3 | 0.017 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GLUT4/clathrin heavy chain/ACAP1 | -0.011 | 0.046 | -10000 | 0 | -0.28 | 3 | 3 |
EXOC6 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLD1 | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PLD2 | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EXOC5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PIP5K1C | 0.029 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SDC1 | 0.026 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ARF6/GDP | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
EXOC7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
E-cadherin/beta catenin | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Phosphatidic acid | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
endocytosis | -0.014 | 0.054 | 0.36 | 4 | -10000 | 0 | 4 |
SCAMP2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ADRB2 | -0.002 | 0.094 | -10000 | 0 | -0.31 | 12 | 12 |
EXOC3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ASAP2 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
Dynamin 2/GDP | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KLC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AVPR2 | -0.002 | 0.093 | -10000 | 0 | -0.31 | 11 | 11 |
RALA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin | -0.001 | 0.019 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
VEGFR1 homodimer/VEGFB homodimer | 0.021 | 0.08 | -9999 | 0 | -0.76 | 2 | 2 |
VEGFR1 homodimer/NRP1 | 0.012 | 0.08 | -9999 | 0 | -0.77 | 2 | 2 |
mol:DAG | 0.022 | 0.083 | -9999 | 0 | -0.69 | 2 | 2 |
VEGFR1 homodimer/NRP1/VEGFR 121 | 0.019 | 0.075 | -9999 | 0 | -0.71 | 2 | 2 |
CaM/Ca2+ | 0.027 | 0.079 | -9999 | 0 | -0.66 | 2 | 2 |
HIF1A | 0.015 | 0.038 | -9999 | 0 | -0.36 | 2 | 2 |
GAB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | 0.04 | 0.075 | -9999 | 0 | -0.61 | 2 | 2 |
PLCG1 | 0.022 | 0.084 | -9999 | 0 | -0.7 | 2 | 2 |
NOS3 | 0.035 | 0.11 | -9999 | 0 | -0.74 | 3 | 3 |
CBL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:NO | 0.035 | 0.11 | -9999 | 0 | -0.7 | 3 | 3 |
FLT1 | 0.018 | 0.09 | -9999 | 0 | -0.86 | 2 | 2 |
PGF | 0.002 | 0.07 | -9999 | 0 | -0.47 | 4 | 4 |
VEGFR1 homodimer/NRP2/VEGFR121 | 0.011 | 0.11 | -9999 | 0 | -0.87 | 2 | 2 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
eNOS/Hsp90 | 0.041 | 0.1 | -9999 | 0 | -0.67 | 3 | 3 |
endothelial cell proliferation | 0 | 0.12 | -9999 | 0 | -0.66 | 2 | 2 |
mol:Ca2+ | 0.022 | 0.082 | -9999 | 0 | -0.68 | 2 | 2 |
MAPK3 | 0.029 | 0.081 | -9999 | 0 | -0.6 | 2 | 2 |
MAPK1 | 0.029 | 0.081 | -9999 | 0 | -0.6 | 2 | 2 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLGF homodimer | 0.002 | 0.07 | -9999 | 0 | -0.47 | 4 | 4 |
PRKACA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RP11-342D11.1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CAV1 | -0.004 | 0.089 | -9999 | 0 | -0.49 | 6 | 6 |
VEGFA homodimer | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFR1 homodimer/VEGFA homodimer | 0.021 | 0.08 | -9999 | 0 | -0.76 | 2 | 2 |
platelet activating factor biosynthetic process | 0.034 | 0.079 | -9999 | 0 | -0.58 | 2 | 2 |
PI3K | 0.028 | 0.08 | -9999 | 0 | -0.66 | 2 | 2 |
PRKCA | 0.024 | 0.086 | -9999 | 0 | -0.64 | 2 | 2 |
PRKCB | -0.016 | 0.13 | -9999 | 0 | -0.64 | 2 | 2 |
VEGFR1 homodimer/PLGF homodimer | 0.015 | 0.091 | -9999 | 0 | -0.64 | 3 | 3 |
VEGFA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
VEGFB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:IP3 | 0.022 | 0.083 | -9999 | 0 | -0.69 | 2 | 2 |
RASA1 | 0.028 | 0.075 | -9999 | 0 | -0.7 | 2 | 2 |
NRP2 | -0.016 | 0.12 | -9999 | 0 | -0.52 | 10 | 10 |
VEGFR1 homodimer | 0.018 | 0.09 | -9999 | 0 | -0.86 | 2 | 2 |
VEGFB homodimer | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NCK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
eNOS/Caveolin-1 | 0.034 | 0.12 | -9999 | 0 | -0.77 | 3 | 3 |
PTPN11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | 0.027 | 0.079 | -9999 | 0 | -0.65 | 2 | 2 |
mol:L-citrulline | 0.035 | 0.11 | -9999 | 0 | -0.7 | 3 | 3 |
VEGFR1 homodimer/VEGFA homodimer/CBL/CD2AP | 0.033 | 0.072 | -9999 | 0 | -0.67 | 2 | 2 |
VEGFR1 homodimer/VEGFA homodimer/NCK1 | 0.027 | 0.075 | -9999 | 0 | -0.7 | 2 | 2 |
CD2AP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K/GAB1 | 0.033 | 0.076 | -9999 | 0 | -0.62 | 2 | 2 |
PDPK1 | 0.032 | 0.075 | -9999 | 0 | -0.62 | 2 | 2 |
VEGFR1 homodimer/VEGFA homodimer/SHP2 | 0.027 | 0.075 | -9999 | 0 | -0.7 | 2 | 2 |
mol:NADP | 0.035 | 0.11 | -9999 | 0 | -0.7 | 3 | 3 |
HSP90AA1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ubiquitin-dependent protein catabolic process | 0.032 | 0.071 | -9999 | 0 | -0.66 | 2 | 2 |
VEGFR1 homodimer/NRP2 | 0.004 | 0.12 | -9999 | 0 | -0.57 | 6 | 6 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
TRAF6/ASK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRAF2/ASK1 | 0.016 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ATM | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K3 | 0.031 | 0.019 | -10000 | 0 | -10000 | 0 | 0 |
response to stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP2K6 | 0.031 | 0.042 | -10000 | 0 | -10000 | 0 | 0 |
hyperosmotic response | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
response to oxidative stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GADD45G | 0.005 | 0.053 | -10000 | 0 | -0.42 | 3 | 3 |
TXN | 0.008 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CALM1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GADD45A | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GADD45B | 0.007 | 0.043 | -10000 | 0 | -0.42 | 2 | 2 |
MAP3K1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K6 | -0.002 | 0.092 | -10000 | 0 | -0.64 | 4 | 4 |
MAP3K7 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K4 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:Ca2+ | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
ASK1/ASK2 | 0.008 | 0.069 | -10000 | 0 | -0.47 | 4 | 4 |
TAK1/TAB family | 0.002 | 0.016 | 0.19 | 1 | -10000 | 0 | 1 |
RAC1/OSM/MEKK3 | 0.023 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRAF2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1/OSM/MEKK3/MKK3 | 0 | 0.003 | -10000 | 0 | -10000 | 0 | 0 |
TRAF6 | 0.008 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:LPS | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CAMK2B | -0.036 | 0.13 | -10000 | 0 | -0.42 | 21 | 21 |
CCM2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/CAMKIIB | -0.012 | 0.079 | -10000 | 0 | -0.24 | 21 | 21 |
MAPK11 | 0.006 | 0.056 | -10000 | 0 | -0.52 | 2 | 2 |
response to DNA damage stimulus | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CaM/Ca2+/CAMKIIB/ASK1 | -0.003 | 0.072 | -10000 | 0 | -10000 | 0 | 0 |
OSM/MEKK3 | 0.018 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TAOK1 | 0.013 | 0.028 | -10000 | 0 | -0.37 | 1 | 1 |
TAOK2 | 0.015 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TAOK3 | 0.015 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K7IP1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K7IP2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K10 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAP3K3 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TRX/ASK1 | 0.014 | 0 | -10000 | 0 | -10000 | 0 | 0 |
GADD45/MTK1/MTK1 | 0.023 | 0.034 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
SMAD4 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
SMAD2 | 0.013 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
SMAD3 | 0.033 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
SMAD3/SMAD4 | 0.039 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
SMAD4/Ubc9/PIASy | 0.022 | 0.03 | -9999 | 0 | -0.39 | 1 | 1 |
SMAD2/SMAD2/SMAD4 | 0.034 | 0.024 | -9999 | 0 | -10000 | 0 | 0 |
PPM1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SMAD2/SMAD4 | 0.017 | 0.028 | -9999 | 0 | -0.35 | 1 | 1 |
MAP3K1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRAP-1/SMAD4 | 0.013 | 0.049 | -9999 | 0 | -0.47 | 2 | 2 |
MAPK3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NUP214 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CTDSPL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KPNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TGFBRAP1 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
UBE2I | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NUP153 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KPNA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIAS4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
chromatin modification | 0.043 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
CLOCK | 0.015 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
TIMELESS/CRY2 | 0.038 | 0.013 | -10000 | 0 | -10000 | 0 | 0 |
DEC1/BMAL1 | 0.008 | 0.042 | -10000 | 0 | -0.28 | 4 | 4 |
ATR | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
NR1D1 | 0.036 | 0.026 | -10000 | 0 | -10000 | 0 | 0 |
ARNTL | 0.015 | 0.002 | -10000 | 0 | -10000 | 0 | 0 |
TIMELESS | 0.037 | 0.014 | -10000 | 0 | -10000 | 0 | 0 |
NPAS2 | 0.011 | 0.046 | -10000 | 0 | -0.63 | 1 | 1 |
CRY2 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:CO | -0.012 | 0.006 | 0.065 | 1 | -10000 | 0 | 1 |
CHEK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mol:HEME | 0.012 | 0.006 | -10000 | 0 | -0.065 | 1 | 1 |
PER1 | 0.001 | 0.078 | -10000 | 0 | -0.52 | 4 | 4 |
BMAL/CLOCK/NPAS2 | 0.037 | 0.031 | -10000 | 0 | -0.38 | 1 | 1 |
BMAL1/CLOCK | 0.041 | 0.032 | -10000 | 0 | -10000 | 0 | 0 |
S phase of mitotic cell cycle | 0.043 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
TIMELESS/CHEK1/ATR | 0.044 | 0.012 | -10000 | 0 | -10000 | 0 | 0 |
mol:NADPH | 0.012 | 0.006 | -10000 | 0 | -0.065 | 1 | 1 |
PER1/TIMELESS | 0.032 | 0.046 | -10000 | 0 | -10000 | 0 | 0 |
PER1-2 / CRY1-2 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
DEC1 | -0.005 | 0.06 | -10000 | 0 | -0.42 | 4 | 4 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
regulation of centriole-centriole cohesion | -0.011 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BUB1B | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLK1 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLK1S1 | 0.014 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
KIF2A | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of mitotic centrosome separation | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GOLGA2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Hec1/SPC24 | 0.027 | 0.026 | -9999 | 0 | -0.33 | 1 | 1 |
WEE1 | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
cytokinesis | 0.028 | 0.035 | -9999 | 0 | -0.45 | 1 | 1 |
PP2A-alpha B56 | 0.033 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AURKA | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PICH/PLK1 | 0.031 | 0.033 | -9999 | 0 | -0.29 | 2 | 2 |
CENPE | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GTP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of microtubule depolymerization | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP2CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FZR1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TPX2 | 0.013 | 0.02 | -9999 | 0 | -0.26 | 1 | 1 |
PAK1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SPC24 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
FBXW11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CLSPN | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GORASP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
metaphase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NLP | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2 phase of mitotic cell cycle | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STAG2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GRASP65/GM130/RAB1/GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
spindle elongation | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ODF2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BUB1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TPT1 | 0.014 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
CDC25C | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC25B | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SGOL1 | 0.011 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CCNB1/CDK1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC14B | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC20 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLK1/PBIP1 | -0.003 | 0.033 | -9999 | 0 | -0.33 | 2 | 2 |
mitosis | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FBXO5 | 0.021 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CDC2 | 0.001 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NDC80 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
metaphase plate congression | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ERCC6L | 0.029 | 0.034 | -9999 | 0 | -0.3 | 2 | 2 |
NLP/gamma Tubulin | 0.014 | 0 | -9999 | 0 | -10000 | 0 | 0 |
microtubule cytoskeleton organization | 0.014 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition DNA damage checkpoint | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP1R12A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
interphase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PLK1/PRC1-2 | 0.027 | 0.026 | -9999 | 0 | -0.33 | 1 | 1 |
GRASP65/GM130/RAB1/GTP/PLK1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAB1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
prophase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Aurora A/BORA | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mitotic prometaphase | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.033 | 0 | -9999 | 0 | -10000 | 0 | 0 |
microtubule-based process | 0.021 | 0.027 | -9999 | 0 | -0.35 | 1 | 1 |
Golgi organization | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Cohesin/SA2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP1CB/MYPT1 | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KIF20A | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
APC/C/CDC20 | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP2R1A | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
chromosome segregation | -0.003 | 0.033 | -9999 | 0 | -0.32 | 2 | 2 |
PRC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ECT2 | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
C13orf34 | 0.02 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NUDC | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
regulation of attachment of spindle microtubules to kinetochore | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
spindle assembly | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
spindle stabilization | 0.014 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
APC/C/HCDH1 | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MKLP2/PLK1 | 0.021 | 0.027 | -9999 | 0 | -0.35 | 1 | 1 |
CCNB1 | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PPP1CB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BTRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ROCK2 | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TUBG1 | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
G2/M transition of mitotic cell cycle | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MLF1IP | 0.005 | 0.05 | -9999 | 0 | -0.48 | 2 | 2 |
INCENP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
Insulin responsive Vesicles | -0.006 | 0.029 | -9999 | 0 | -10000 | 0 | 0 |
CaM/Ca2+ | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
STXBP4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:glucose | 0.033 | 0.042 | -9999 | 0 | -10000 | 0 | 0 |
YWHAZ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CALM1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAQ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TBC1D4 | 0.018 | 0.035 | -9999 | 0 | -0.47 | 1 | 1 |
mol:Ca2+ | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAH | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SNARE/Synip | 0.024 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ASIP | 0.006 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
PRKCI | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
AS160/CaM/Ca2+ | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOQ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GYS1 | 0.028 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PRKCZ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TRIP10 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
TC10/GTP/CIP4/Exocyst | 0.016 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AS160/14-3-3 | 0.039 | 0.023 | -9999 | 0 | -10000 | 0 | 0 |
VAMP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SLC2A4 | 0.033 | 0.044 | -9999 | 0 | -10000 | 0 | 0 |
STX4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GSK3B | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SFN | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
LNPEP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL2L1 | 0.02 | 0 | -10000 | 0 | -10000 | 0 | 0 |
BAD/BCL-XL/YWHAZ | 0.03 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CDKN1B | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
CDKN1A | 0.026 | 0.05 | -10000 | 0 | -0.35 | 3 | 3 |
FRAP1 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PRKDC | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
FOXO3 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
AKT1 | -0.002 | 0.033 | -10000 | 0 | -0.46 | 1 | 1 |
BAD | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT3 | -0.003 | 0.074 | -10000 | 0 | -0.37 | 6 | 6 |
mol:GTP | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO4 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
AKT1/ASK1 | 0.029 | 0.033 | -10000 | 0 | -0.43 | 1 | 1 |
BAD/YWHAZ | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RICTOR | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RAF1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
JNK cascade | 0.002 | 0.03 | 0.41 | 1 | -10000 | 0 | 1 |
TSC1 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
YWHAZ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT1/RAF1 | 0.031 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
EP300 | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
mol:GDP | 0.025 | 0.035 | -10000 | 0 | -0.46 | 1 | 1 |
mol:PI-3-4-5-P3 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TSC2 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
YWHAQ | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
TBC1D4 | 0.019 | 0.03 | -10000 | 0 | -0.39 | 1 | 1 |
MAP3K5 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MAPKAP1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
negative regulation of cell cycle | -0.037 | 0.017 | -10000 | 0 | -10000 | 0 | 0 |
YWHAH | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT1S1 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
CASP9 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
YWHAB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
p27Kip1/KPNA1 | 0.036 | 0.032 | -10000 | 0 | -0.41 | 1 | 1 |
GBL | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
PDK1/Src/Hsp90 | 0.024 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT2/p21CIP1 | -0.006 | 0.042 | -10000 | 0 | -0.32 | 3 | 3 |
KIAA1303 | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
mTOR/RHEB/GTP/Raptor/GBL | 0.016 | 0.01 | -10000 | 0 | -10000 | 0 | 0 |
CHUK | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
BAD/BCL-XL | 0.042 | 0.032 | -10000 | 0 | -0.4 | 1 | 1 |
mTORC2 | 0.015 | 0 | -10000 | 0 | -10000 | 0 | 0 |
AKT2 | 0.015 | 0 | -10000 | 0 | -10000 | 0 | 0 |
FOXO1-3a-4/14-3-3 family | 0.051 | 0.027 | -10000 | 0 | -0.27 | 1 | 1 |
PDPK1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
MDM2 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
MAPKKK cascade | -0.03 | 0.033 | 0.43 | 1 | -10000 | 0 | 1 |
MDM2/Cbp/p300 | 0.04 | 0.039 | -10000 | 0 | -0.39 | 1 | 1 |
TSC1/TSC2 | 0.036 | 0.033 | -10000 | 0 | -0.42 | 1 | 1 |
proteasomal ubiquitin-dependent protein catabolic process | 0.038 | 0.038 | -10000 | 0 | -0.38 | 1 | 1 |
glucose import | 0.009 | 0.069 | -10000 | 0 | -0.35 | 4 | 4 |
mTOR/RHEB/GDP/Raptor/GBL/PRAS40 | 0.027 | 0.021 | -10000 | 0 | -0.26 | 1 | 1 |
response to stress | 0 | 0 | -10000 | 0 | -10000 | 0 | 0 |
SLC2A4 | 0.009 | 0.069 | -10000 | 0 | -0.35 | 4 | 4 |
GSK3A | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
FOXO1 | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
GSK3B | 0.03 | 0.034 | -10000 | 0 | -0.44 | 1 | 1 |
SFN | 0.009 | 0.047 | -10000 | 0 | -0.64 | 1 | 1 |
G1/S transition of mitotic cell cycle | 0.036 | 0.033 | -10000 | 0 | -0.42 | 1 | 1 |
p27Kip1/14-3-3 family | 0.042 | 0.017 | -10000 | 0 | -10000 | 0 | 0 |
PRKACA | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
KPNA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
HSP90AA1 | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
YWHAG | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
RHEB | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
CREBBP | 0.012 | 0 | -10000 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
G6PC | 0.023 | 0.06 | -9999 | 0 | -10000 | 0 | 0 |
PLK1 | 0.071 | 0.097 | -9999 | 0 | -10000 | 0 | 0 |
CDKN1B | 0.12 | 0.046 | -9999 | 0 | -10000 | 0 | 0 |
FOXO3 | 0.069 | 0.1 | -9999 | 0 | -10000 | 0 | 0 |
KAT2B | 0.017 | 0.047 | -9999 | 0 | -0.62 | 1 | 1 |
FOXO1/SIRT1 | 0.008 | 0.037 | -9999 | 0 | -10000 | 0 | 0 |
CAT | 0.071 | 0.097 | -9999 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | 0.022 | 0.012 | -9999 | 0 | -10000 | 0 | 0 |
FOXO1 | 0.028 | 0.038 | -9999 | 0 | -10000 | 0 | 0 |
MAPK10 | -0.002 | 0.1 | -9999 | 0 | -0.33 | 12 | 12 |
mol:GTP | 0.002 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FOXO4 | 0.076 | 0.054 | -9999 | 0 | -10000 | 0 | 0 |
response to oxidative stress | 0.01 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
FOXO3A/SIRT1 | 0.014 | 0.063 | -9999 | 0 | -10000 | 0 | 0 |
XPO1 | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EP300 | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
BCL2L11 | 0.029 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
FOXO1/SKP2 | 0.031 | 0.034 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | 0.01 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
RAN | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GADD45A | 0.1 | 0.038 | -9999 | 0 | -10000 | 0 | 0 |
YWHAQ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FOXO1/14-3-3 family | 0.065 | 0.017 | -9999 | 0 | -10000 | 0 | 0 |
MST1 | -0.016 | 0.14 | -9999 | 0 | -0.52 | 13 | 13 |
CSNK1D | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1E | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FOXO4/14-3-3 family | 0.051 | 0.025 | -9999 | 0 | -10000 | 0 | 0 |
YWHAB | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MAPK8 | 0.036 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
MAPK9 | 0.035 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
YWHAG | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAE | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAZ | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SIRT1 | 0.014 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
SOD2 | 0.12 | 0.056 | -9999 | 0 | -10000 | 0 | 0 |
RBL2 | 0.081 | 0.077 | -9999 | 0 | -10000 | 0 | 0 |
RAL/GDP | 0.028 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
CHUK | 0.02 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1G2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAL/GTP | 0.035 | 0.009 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1G1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FASLG | -0.1 | 0.4 | -9999 | 0 | -1.4 | 16 | 16 |
SKP2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
USP7 | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
IKBKB | 0.018 | 0.032 | -9999 | 0 | -0.4 | 1 | 1 |
CCNB1 | 0.071 | 0.097 | -9999 | 0 | -10000 | 0 | 0 |
FOXO1-3a-4/beta catenin | 0.12 | 0.08 | -9999 | 0 | -10000 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0.031 | 0.034 | -9999 | 0 | -10000 | 0 | 0 |
CSNK1A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SGK1 | 0.008 | 0.077 | -9999 | 0 | -0.45 | 5 | 5 |
CSNK1G3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1 | 0.022 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
ZFAND5 | 0.078 | 0.048 | -9999 | 0 | -10000 | 0 | 0 |
SFN | 0.009 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
CDK2 | 0.011 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
FOXO3A/14-3-3 | 0.058 | 0.032 | -9999 | 0 | -10000 | 0 | 0 |
CREBBP | 0.011 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
FBXO32 | 0.069 | 0.1 | -9999 | 0 | -10000 | 0 | 0 |
BCL6 | 0.08 | 0.082 | -9999 | 0 | -10000 | 0 | 0 |
RALB | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RALA | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
YWHAH | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
BCL3/RelA | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
FBXW11 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/c-Rel | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA/I kappa B alpha | 0.025 | 0.05 | -9999 | 0 | -10000 | 0 | 0 |
NFKBIA | 0.007 | 0.054 | -9999 | 0 | -10000 | 0 | 0 |
MAPK14 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p105/p50 | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
ARRB2 | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
REL | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
response to oxidative stress | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
BCL3/NF kappa B1 p50 | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
response to UV | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p105/RelA | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50 dimer | 0.016 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
PIK3R1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NFKB1 | 0.019 | 0.022 | -9999 | 0 | -0.28 | 1 | 1 |
RELA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
positive regulation of anti-apoptosis | 0.013 | 0.054 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA/I kappa B alpha/beta Arrestin2 | 0.028 | 0.048 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p50/RelA | 0.013 | 0.054 | -9999 | 0 | -10000 | 0 | 0 |
IKBKB | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
beta TrCP1/SCF ubiquitin ligase complex | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
SYK | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
I kappa B alpha/PIK3R1 | 0.013 | 0.051 | -9999 | 0 | -10000 | 0 | 0 |
cell death | 0.027 | 0.047 | -9999 | 0 | -10000 | 0 | 0 |
NF kappa B1 p105/c-Rel | 0.023 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
LCK | -0.051 | 0.16 | -9999 | 0 | -0.47 | 25 | 25 |
BCL3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
HDAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1/HDAC4 | -0.001 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
MDM2/SUMO1 | 0.027 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
HDAC4 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1/HDAC1 | -0.001 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
SUMO1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NPC/RanGAP1/SUMO1 | 0.015 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
XPO1 | 0.025 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:23636 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAN | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:8021 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RANBP2 | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
SUMO1/HDAC4 | 0.027 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
SUMO1/HDAC1 | 0.027 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
RANGAP1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MDM2/SUMO1/SUMO1 | 0.031 | 0 | -9999 | 0 | -10000 | 0 | 0 |
NPC/RanGAP1/SUMO1/RanBP2/Ubc9 | 0.019 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP | 0.024 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:23225 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
MDM2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
UBE2I | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Ran/GTP/Exportin 1 | 0.029 | 0.007 | -9999 | 0 | -10000 | 0 | 0 |
NPC | 0.006 | 0.015 | -9999 | 0 | -0.21 | 1 | 1 |
PIAS2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIAS1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:9972 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
keratinocyte differentiation | 0.043 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
adherens junction organization | 0.039 | 0.022 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GDP | 0.046 | 0.026 | -9999 | 0 | -10000 | 0 | 0 |
FMN1 | 0.035 | 0.034 | -9999 | 0 | -0.3 | 1 | 1 |
mol:IP3 | 0.036 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin | 0.032 | 0.02 | -9999 | 0 | -10000 | 0 | 0 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AKT1 | 0.042 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/beta catenin-gamma catenin/alpha catenin/p120 catenin | 0.037 | 0.021 | -9999 | 0 | -10000 | 0 | 0 |
CTNND1 | 0.013 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0.037 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
VASP | 0.038 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
ZYX | 0.038 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
JUB | 0.038 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
EGFR(dimer) | 0.036 | 0.028 | -9999 | 0 | -10000 | 0 | 0 |
E-cadherin/beta catenin-gamma catenin | 0 | 0.002 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-3-4-5-P3 | 0.036 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
PIK3CA | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
PI3K | 0.037 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
FYN | 0.038 | 0.041 | -9999 | 0 | -0.32 | 1 | 1 |
mol:Ca2+ | 0.036 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
JUP | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIK3R1 | 0.013 | 0.001 | -9999 | 0 | -10000 | 0 | 0 |
mol:DAG | 0.036 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
CDH1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GDP | 0.046 | 0.026 | -9999 | 0 | -10000 | 0 | 0 |
establishment of polarity of embryonic epithelium | 0.037 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
SRC | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RHOA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EGFR | 0.007 | 0.043 | -9999 | 0 | -0.42 | 2 | 2 |
CASR | 0.033 | 0.035 | -9999 | 0 | -10000 | 0 | 0 |
RhoA/GTP | -0.001 | 0.014 | -9999 | 0 | -10000 | 0 | 0 |
AKT2 | 0.042 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
actin cable formation | 0.04 | 0.033 | -9999 | 0 | -10000 | 0 | 0 |
apoptosis | -0.04 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
CTNNA1 | 0.01 | 0.047 | -9999 | 0 | -0.64 | 1 | 1 |
mol:GDP | 0.041 | 0.027 | -9999 | 0 | -10000 | 0 | 0 |
PIP5K1A | 0.038 | 0.019 | -9999 | 0 | -10000 | 0 | 0 |
PLCG1 | 0.036 | 0.018 | -9999 | 0 | -10000 | 0 | 0 |
Rac1/GTP | -0.003 | 0.021 | -9999 | 0 | -10000 | 0 | 0 |
homophilic cell adhesion | 0.001 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
E-cadherin/beta catenin-gamma catenin | 0.024 | 0 | -9999 | 0 | -9999 | 0 | 0 |
E-cadherin/beta catenin | 0.018 | 0 | -9999 | 0 | -9999 | 0 | 0 |
CTNNB1 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
JUP | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
CDH1 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
coatomer protein complex | -0.001 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:79658 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GDP/Membrin/GBF1/p115/Brefeldin A | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AP2 | 0.018 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:DAG | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Arfaptin 2/Rac/GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CLTB | 0.01 | 0.031 | -9999 | 0 | -0.42 | 1 | 1 |
coatomer protein complex/ARF1/GTP/ER cargo protein | 0.022 | 0.01 | -9999 | 0 | -10000 | 0 | 0 |
CD4 | -0.032 | 0.16 | -9999 | 0 | -0.59 | 14 | 14 |
CLTA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GTP | 0.001 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARFGAP1 | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:PI-4-5-P2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
coatomer protein complex/ARF1/GTP/ARF-GAP1/ER cargo protein | 0.024 | 0.005 | -9999 | 0 | -10000 | 0 | 0 |
mol:Choline | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
DDEF1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AP2M1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
EntrezGene:1313 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
actin filament polymerization | 0.015 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac/GTP | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/GGA3/ARF-GAP1 | 0.023 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARFIP2 | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
COPA | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
RAC1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/coatomer protein complex | 0.022 | 0.006 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/ARHGAP10 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GGA3 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/Membrin | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
AP2A1 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
coatomer protein complex/ARF1/GTP/ARF-GAP1 | 0.024 | 0.008 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GDP/Membrin | 0.017 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Arfaptin 2/Rac/GDP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CYTH2 | 0.012 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/GGA3 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:ATP | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
Rac/GDP | 0.009 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Brefeldin A | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP | 0.015 | 0.062 | -9999 | 0 | -0.23 | 11 | 11 |
PLD2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF-GAP1/v-SNARE | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
PIP5K1A | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/Membrin/GBF1/p115 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Phosphatic acid | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
mol:Phosphatidic acid | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
KDEL Receptor/Ligand/ARF-GAP1 | 0.01 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GOSR2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
USO1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
GBF1 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
ARF1/GTP/Arfaptin 2 | 0 | 0 | -9999 | 0 | -10000 | 0 | 0 |
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex | -0.004 | 0.1 | -9999 | 0 | -0.39 | 11 | 11 |
Entity | Mean | Std.Dev | Mean.of.Up.Perturbations | Number.of.Up.Perturbations | Mean.of.Down.Perturbations | Number.of.Down.Perturbations | Number.of.Total.Perturbations |
---|---|---|---|---|---|---|---|
IKK alpha homodimer | 0.018 | 0 | -9999 | 0 | -9999 | 0 | 0 |
FBXW11 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
proteasomal ubiquitin-dependent protein catabolic process | 0 | 0 | -9999 | 0 | -9999 | 0 | 0 |
beta TrCP1/SCF ubiquitin ligase complex | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
CHUK | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
NF kappa B2 p100/RelB | 0.036 | 0 | -9999 | 0 | -9999 | 0 | 0 |
NFKB1 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
MAP3K14 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
NF kappa B1 p50/RelB | 0.018 | 0 | -9999 | 0 | -9999 | 0 | 0 |
RELB | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
NFKB2 | 0.012 | 0 | -9999 | 0 | -9999 | 0 | 0 |
NF kappa B2 p52/RelB | 0.016 | 0 | -9999 | 0 | -9999 | 0 | 0 |
regulation of B cell activation | 0.016 | 0 | -9999 | 0 | -9999 | 0 | 0 |
pid_entity | TCGA.G4.6628 | TCGA.G4.6626 | TCGA.G4.6625 | TCGA.G4.6588 |
---|---|---|---|---|
109_MAP3K5 | -0.03 | 0.048 | 0.048 | -0.18 |
47_PPARGC1A | -0.63 | 0.012 | 0.012 | 0.012 |
105_BMP4 | 0.012 | -0.63 | 0.012 | 0.012 |
105_BMP6 | 0.012 | 0.012 | 0.012 | 0.012 |
105_BMP7 | -0.63 | -0.63 | 0.012 | 0.012 |
105_BMP2 | 0.012 | 0.012 | 0.012 | 0.012 |
131_RELN/VLDLR | 0.031 | -0.35 | -0.2 | -0.35 |
30_TGFB1/TGF beta receptor Type II | 0.011 | 0.016 | 0.011 | 0.011 |
84_STAT5B | 0.04 | 0.04 | 0.042 | -0.041 |
84_STAT5A | 0.04 | 0.04 | 0.042 | -0.041 |
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Expression Data Normalization = Tumor samples were used to median center the expression data used in this analysis.
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mRNASeq Expression File Used = /xchip/cga/gdac-prod/tcga-gdac/jobResults/mRNAseq_preprocessor/COAD-TP/3353103/COAD-TP.uncv2.mRNAseq_RSEM_normalized_log2_PARADIGM.txt
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Copy Number File Used = Copy number data was not used in this analysis.
Both copy number and expression data are incorporated into PARADIGM's inference. Whenever normal tissue controls are available for analysis in the expression data, each patient's gene-value is normalized by subtracting the gene's median level observed in the normal control. Copy number data is also normalized to reflect the difference in copy number between a gene's levels detected in tumor versus control (e.g. blood normal). The collection of pathways used by PARADIGM includes those from NCI-PID on September 15, 2009 containing 131 pathways, 11,563 interactions, and 7,204 entities. All gene identifiers were translated into HUGO standard identifiers wherever possible. We refer to molecular entities as "concepts," which include gene products such as proteins and miRNAs, small molecules, protein complexes, and abstract concepts. Each concept is represented as "node" in PARADIGM's graphical model. The abstract concepts correspond to general cellular processes (such as "apoptosis" or "DNA damage response") and families of genes that share functional activity such as the RAS family of signal transducers. Various types of concept-concept interactions are included in the pathways including protein-protein interactions, transcriptional regulatory interactions, and protein modifications such as phosphorylation and ubiquitinylation interactions.
The PARADIGM algorithm (described in PMID: 20529912) assigns an integrated pathway level (IPL) reflecting the activity of a concept determined through a belief propagation strategy. The belief propagation is given the copy number and gene expression measurements of all of the genes and iteratively updates hidden states reflecting the activities of all of the genes in a pathway so as to maximize the likelihood of the observed data given the interactions in the pathway. In the end, the inferred level of a concept reflects both the data observed for the concept and the neighborhood of activity surrounding the concept.
The significance of the IPL obtained for each concept in each patient sample is assessed using a permutation analysis. Importantly, the permutation analysis preserves data tuples so as to preserve any implicit correlations between the different data modalities. For example, genes that are deleted have concomitantly lower expression levels. Preserving the copy number and expression pairs therefore retains this data property. The simulation therefore makes "null samples" by permuting data tuples across all of the genes in the genome so that each gene in a null sample is associated with a random tuple of another gene with equal probability. This approach has the added benefit of preserving the pathway structure so that every observed IPL can be compared to a distribution of random IPLs derived from exactly the same interaction context. PARADIGM inferences are then obtained for 1000 "null" patients and serve as a background distribution to contrast the observed IPLs against. Pathway concepts are excluded from further analysis if they did not obtain a minimum IPL of 0.5 in any patient sample both observed or simulated.
An IPL I(i,j) for concept i in sample j, is considered to be deviated if its absolute level is two standard deviations from the average level observed for concept i in the 1000 null samples. The degree to which a concept has significantly altered levels across a patient cohort is summarized in the proportion of deviated samples (PDS) score. For example, a protein with a PDS of 0.10 reflects that the protein's level of activity was inferred to be significantly higher or lower in tumors compared to normal in 10% of the patient samples. An average PDS for a pathway is also reported by computing the mean PDS over all concepts in the pathway.
This is an experimental feature. The full results of the analysis summarized in this report can be downloaded from the TCGA Data Coordination Center.