HotNet pathway analysis of mutation and copy number data
Colon/Rectal Adenocarcinoma (Primary solid tumor)
23 May 2013  |  analyses__2013_05_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): HotNet pathway analysis of mutation and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C1KH0KB1
- Overview
+ Introduction
- Summary

There were 82 significant subnetworks identified in HotNet analysis.

- Results
- Significant subnetworks

HotNet identifies 82 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.

Table 1.  Get Full Table Top 10 out of 82 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.

Network No.ofgenes p-value RepeatTimes
PLXNA2(52),KIAA1199(24),UBAP2L(50) 3 0 3
APOA1BP(46),PLTP(3),APOA2(45) 3 0 2
ARHGEF2(49),F11R(46),CGN(48) 3 0 2
CD53(60),CD58(59),CD2(59) 3 0 2
COL4A4(24),COL4A3(19),HABP2(58) 3 0 2
CRELD2(85),CHRNA4(1),CHRNB2(48) 3 0 2
FOXG1(5),PAX9(1),KDM5B(53) 3 0 2
GHRHR(112),NPY(112),GHRL(33) 3 0 2
HBXIP(60),RAB15(2),RABIF(46) 3 0 2
HOXA5(112),FOXA2(1),PBX1(46) 3 0 2
+ Methods & Data