Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	36.0	1254.0	34.0	-0.769	0.008	1000.0	-1000.0	-0.064	-1000.0
FOXA2 and FOXA3 transcription factor networks	26.0	1229.0	46.0	-1.534	0.013	1000.0	-1000.0	-0.104	-1000.0
PDGFR-alpha signaling pathway	16.0	734.0	44.0	-0.365	0.022	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by the Hedgehog family	10.0	567.0	52.0	-0.63	0.19	1000.0	-1000.0	-0.075	-1000.0
Glypican 1 network	9.0	444.0	48.0	-0.476	0.023	1000.0	-1000.0	-0.049	-1000.0
Signaling events regulated by Ret tyrosine kinase	8.0	712.0	82.0	-0.265	0.008	1000.0	-1000.0	-0.083	-1000.0
BMP receptor signaling	7.0	585.0	81.0	-0.762	0.013	1000.0	-1000.0	-0.096	-1000.0
Reelin signaling pathway	6.0	339.0	56.0	-0.208	0.008	1000.0	-1000.0	-0.077	-1000.0
Ephrin B reverse signaling	6.0	333.0	48.0	-0.249	0.026	1000.0	-1000.0	-0.077	-1000.0
Thromboxane A2 receptor signaling	5.0	601.0	105.0	-0.162	0.029	1000.0	-1000.0	-0.065	-1000.0
HIF-1-alpha transcription factor network	5.0	442.0	76.0	-1.016	0.014	1000.0	-1000.0	-0.156	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	644.0	120.0	-0.576	0.221	1000.0	-1000.0	-0.078	-1000.0
Endothelins	4.0	418.0	96.0	-0.615	0.016	1000.0	-1000.0	-0.085	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	308.0	68.0	-0.658	0.058	1000.0	-1000.0	-0.156	-1000.0
IL23-mediated signaling events	4.0	243.0	60.0	-0.305	0.013	1000.0	-1000.0	-0.167	-1000.0
FOXM1 transcription factor network	4.0	216.0	51.0	-0.338	0.016	1000.0	-1000.0	-0.188	-1000.0
ErbB2/ErbB3 signaling events	3.0	199.0	65.0	-0.112	0.015	1000.0	-1000.0	-0.061	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	185.0	54.0	-0.208	0.018	1000.0	-1000.0	-0.093	-1000.0
IL4-mediated signaling events	3.0	333.0	91.0	-0.502	0.296	1000.0	-1000.0	-0.176	-1000.0
amb2 Integrin signaling	3.0	308.0	82.0	-0.589	0.008	1000.0	-1000.0	-0.08	-1000.0
Integrins in angiogenesis	3.0	262.0	84.0	-0.657	0.018	1000.0	-1000.0	-0.097	-1000.0
Syndecan-1-mediated signaling events	2.0	89.0	34.0	-0.271	0.008	1000.0	-1000.0	-0.065	-1000.0
Circadian rhythm pathway	2.0	64.0	22.0	-0.414	0.01	1000.0	-1000.0	-0.076	-1000.0
Osteopontin-mediated events	2.0	97.0	38.0	-0.326	0.008	1000.0	-1000.0	-0.09	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	143.0	61.0	-0.364	0.063	1000.0	-1000.0	-0.071	-1000.0
IL1-mediated signaling events	2.0	154.0	62.0	-0.35	0.044	1000.0	-1000.0	-0.09	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	127.0	52.0	-0.524	0.044	1000.0	-1000.0	-0.056	-1000.0
FoxO family signaling	2.0	188.0	64.0	-0.731	0.055	1000.0	-1000.0	-0.086	-1000.0
Effects of Botulinum toxin	2.0	58.0	26.0	-0.311	0.01	1000.0	-1000.0	-0.056	-1000.0
Nongenotropic Androgen signaling	2.0	135.0	52.0	-0.093	0.013	1000.0	-1000.0	-0.06	-1000.0
TCGA08_rtk_signaling	2.0	57.0	26.0	-0.364	0.02	1000.0	-1000.0	-0.021	-1000.0
LPA receptor mediated events	2.0	227.0	102.0	-0.076	0.026	1000.0	-1000.0	-0.083	-1000.0
IL6-mediated signaling events	2.0	152.0	75.0	-0.18	0.039	1000.0	-1000.0	-0.09	-1000.0
EGFR-dependent Endothelin signaling events	2.0	46.0	21.0	-0.06	0.008	1000.0	-1000.0	-0.069	-1000.0
Plasma membrane estrogen receptor signaling	2.0	212.0	86.0	-0.062	0.039	1000.0	-1000.0	-0.082	-1000.0
E-cadherin signaling in keratinocytes	2.0	99.0	43.0	-0.267	0.031	1000.0	-1000.0	-0.063	-1000.0
Coregulation of Androgen receptor activity	1.0	100.0	76.0	-0.129	0.036	1000.0	-1000.0	-0.057	-1000.0
ErbB4 signaling events	1.0	116.0	69.0	-0.104	0.018	1000.0	-1000.0	-0.081	-1000.0
Visual signal transduction: Cones	1.0	45.0	38.0	-0.111	0.008	1000.0	-1000.0	-0.061	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	18.0	17.0	-0.071	0.035	1000.0	-1000.0	-0.065	-1000.0
Noncanonical Wnt signaling pathway	1.0	26.0	26.0	-0.11	0.021	1000.0	-1000.0	-0.09	-1000.0
Syndecan-2-mediated signaling events	1.0	136.0	69.0	-0.589	0.029	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by PTP1B	1.0	120.0	76.0	-0.51	0.022	1000.0	-1000.0	-0.082	-1000.0
p75(NTR)-mediated signaling	1.0	193.0	125.0	-0.4	0.019	1000.0	-1000.0	-0.094	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	188.0	97.0	-0.121	0.022	1000.0	-1000.0	-0.083	-1000.0
Glucocorticoid receptor regulatory network	1.0	190.0	114.0	-0.358	0.11	1000.0	-1000.0	-0.072	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	60.0	37.0	-0.151	0.01	1000.0	-1000.0	-0.066	-1000.0
FAS signaling pathway (CD95)	1.0	74.0	47.0	-0.281	0.05	1000.0	-1000.0	-0.051	-1000.0
Syndecan-3-mediated signaling events	1.0	47.0	35.0	-0.127	0.008	1000.0	-1000.0	-0.055	-1000.0
Signaling mediated by p38-alpha and p38-beta	1.0	65.0	44.0	-0.217	0.03	1000.0	-1000.0	-0.053	-1000.0
TCR signaling in naïve CD8+ T cells	1.0	105.0	93.0	-0.101	0.039	1000.0	-1000.0	-0.083	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	129.0	74.0	-0.313	0.043	1000.0	-1000.0	-0.081	-1000.0
Syndecan-4-mediated signaling events	1.0	118.0	67.0	-0.349	0.052	1000.0	-1000.0	-0.095	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	161.0	88.0	-0.225	0.03	1000.0	-1000.0	-0.102	-1000.0
Visual signal transduction: Rods	1.0	103.0	52.0	-0.111	0.008	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PRL	1.0	36.0	34.0	-0.071	0.012	1000.0	-1000.0	-0.042	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.022	-1000.0	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	-0.02	0.008	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	102.0	78.0	-0.372	0.025	1000.0	-1000.0	-0.086	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	31.0	17.0	-0.071	0.009	1000.0	-1000.0	-0.045	-1000.0
LPA4-mediated signaling events	0.0	7.0	12.0	-0.052	0.013	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	0.0	16.0	74.0	-0.025	0.033	1000.0	-1000.0	-0.048	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	122.0	136.0	-0.364	0.093	1000.0	-1000.0	-0.077	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.031	1000.0	-1000.0	-0.064	-1000.0
Canonical NF-kappaB pathway	0.0	0.0	39.0	-0.002	0.057	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by HDAC Class II	0.0	12.0	75.0	-0.058	0.027	1000.0	-1000.0	-0.066	-1000.0
IL12-mediated signaling events	0.0	24.0	87.0	-0.104	0.052	1000.0	-1000.0	-0.147	-1000.0
BARD1 signaling events	0.0	22.0	57.0	-0.011	0.038	1000.0	-1000.0	-0.065	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	4.0	28.0	-0.005	0.023	1000.0	-1000.0	-0.055	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.006	0.012	1000.0	-1000.0	-0.024	-1000.0
Ephrin A  reverse signaling	0.0	5.0	7.0	-0.012	0.001	1000.0	-1000.0	-0.031	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.008	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	0.0	31.0	39.0	-0.077	0.013	1000.0	-1000.0	-0.023	-1000.0
Arf6 signaling events	0.0	42.0	62.0	-0.045	0.034	1000.0	-1000.0	-0.063	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	20.0	85.0	-0.032	0.041	1000.0	-1000.0	-0.08	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	51.0	65.0	-0.096	0.052	1000.0	-1000.0	-0.065	-1000.0
Aurora A signaling	0.0	3.0	60.0	-0.037	0.018	1000.0	-1000.0	-0.072	-1000.0
Arf6 downstream pathway	0.0	0.0	43.0	-0.021	0.021	1000.0	-1000.0	-0.045	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.014	0.0	1000.0	-1000.0	-0.038	-1000.0
EPO signaling pathway	0.0	6.0	55.0	-0.098	0.053	1000.0	-1000.0	-0.099	-1000.0
PLK1 signaling events	0.0	0.0	85.0	-0.051	0.012	1000.0	-1000.0	-0.053	-1000.0
Insulin-mediated glucose transport	0.0	13.0	32.0	-0.168	0.021	1000.0	-1000.0	-0.069	-1000.0
mTOR signaling pathway	0.0	0.0	53.0	-0.0	0.023	1000.0	-1000.0	-0.059	-1000.0
IFN-gamma pathway	0.0	56.0	68.0	-0.234	0.045	1000.0	-1000.0	-0.099	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	13.0	68.0	-0.168	0.033	1000.0	-1000.0	-0.067	-1000.0
Nectin adhesion pathway	0.0	48.0	63.0	-0.045	0.029	1000.0	-1000.0	-0.07	-1000.0
Ceramide signaling pathway	0.0	10.0	76.0	-0.062	0.03	1000.0	-1000.0	-0.066	-1000.0
Signaling events mediated by HDAC Class III	0.0	14.0	40.0	-0.071	0.015	1000.0	-1000.0	-0.041	-1000.0
TRAIL signaling pathway	0.0	16.0	48.0	-0.02	0.03	1000.0	-1000.0	-0.059	-1000.0
S1P5 pathway	0.0	3.0	17.0	-0.005	0.017	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	0.0	4.0	49.0	-0.018	0.033	1000.0	-1000.0	-0.051	-1000.0
HIF-2-alpha transcription factor network	0.0	8.0	43.0	-0.124	0.127	1000.0	-1000.0	-0.094	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	73.0	83.0	-0.217	0.07	1000.0	-1000.0	-0.094	-1000.0
S1P1 pathway	0.0	4.0	36.0	-0.004	0.034	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by HDAC Class I	0.0	2.0	104.0	-0.008	0.038	1000.0	-1000.0	-0.075	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.078	0.047	1000.0	-1000.0	-0.017	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	9.0	15.0	-0.003	0.02	1000.0	-1000.0	-0.039	-1000.0
Retinoic acid receptors-mediated signaling	0.0	0.0	58.0	-0.003	0.037	1000.0	-1000.0	-0.07	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.151	0.015	1000.0	-1000.0	-0.069	-1000.0
Atypical NF-kappaB pathway	0.0	20.0	31.0	-0.032	0.018	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by PI3K	0.0	23.0	58.0	-0.029	0.034	1000.0	-1000.0	-0.093	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	8.0	45.0	-0.016	0.046	1000.0	-1000.0	-0.085	-1000.0
Canonical Wnt signaling pathway	0.0	30.0	51.0	-0.138	0.069	1000.0	-1000.0	-0.068	-1000.0
EPHB forward signaling	0.0	39.0	85.0	-0.032	0.042	1000.0	-1000.0	-0.091	-1000.0
Regulation of p38-alpha and p38-beta	0.0	5.0	54.0	-0.032	0.031	1000.0	-1000.0	-0.062	-1000.0
Glypican 2 network	0.0	0.0	4.0	-0.01	-1000.0	1000.0	-1000.0	-0.037	-1000.0
Calcium signaling in the CD4+ TCR pathway	0.0	4.0	31.0	-0.03	0.041	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	21.0	125.0	-0.034	0.061	1000.0	-1000.0	-0.1	-1000.0
IL27-mediated signaling events	0.0	40.0	51.0	-0.184	0.04	1000.0	-1000.0	-0.084	-1000.0
Wnt signaling	0.0	4.0	7.0	-0.021	0.008	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	58.0	76.0	-0.02	0.029	1000.0	-1000.0	-0.079	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.019	1000.0	-1000.0	-0.053	-1000.0
IL2 signaling events mediated by STAT5	0.0	7.0	22.0	-0.031	0.025	1000.0	-1000.0	-0.065	-1000.0
Class I PI3K signaling events	0.0	13.0	73.0	-0.098	0.029	1000.0	-1000.0	-0.075	-1000.0
Arf6 trafficking events	0.0	11.0	71.0	-0.115	0.029	1000.0	-1000.0	-0.073	-1000.0
TCGA08_retinoblastoma	0.0	0.0	8.0	-0.124	0.028	1000.0	-1000.0	-0.023	-1000.0
Regulation of Telomerase	0.0	62.0	102.0	-0.368	0.031	1000.0	-1000.0	-0.098	-1000.0
BCR signaling pathway	0.0	38.0	99.0	-0.098	0.025	1000.0	-1000.0	-0.078	-1000.0
IGF1 pathway	0.0	1.0	57.0	-0.06	0.023	1000.0	-1000.0	-0.087	-1000.0
Insulin Pathway	0.0	17.0	74.0	-0.032	0.026	1000.0	-1000.0	-0.091	-1000.0
VEGFR1 specific signals	0.0	6.0	56.0	-0.018	0.046	1000.0	-1000.0	-0.064	-1000.0
S1P3 pathway	0.0	14.0	42.0	-0.009	0.03	1000.0	-1000.0	-0.06	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	14.0	33.0	-0.121	0.024	1000.0	-1000.0	-0.058	-1000.0
Rapid glucocorticoid signaling	0.0	0.0	20.0	-0.052	0.008	1000.0	-1000.0	-0.036	-1000.0
PDGFR-beta signaling pathway	0.0	12.0	97.0	-0.031	0.042	1000.0	-1000.0	-0.079	-1000.0
S1P4 pathway	0.0	3.0	25.0	-0.005	0.023	1000.0	-1000.0	-0.048	-1000.0
p38 MAPK signaling pathway	0.0	0.0	44.0	-0.079	0.018	1000.0	-1000.0	-0.062	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.001	0.023	1000.0	-1000.0	-0.042	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.008	1000.0	-1000.0	-0.057	-1000.0
Regulation of Androgen receptor activity	0.0	45.0	70.0	-0.116	0.022	1000.0	-1000.0	-0.073	-1000.0
Aurora B signaling	0.0	36.0	67.0	-0.318	0.019	1000.0	-1000.0	-0.074	-1000.0
Total	224	15569	7203	-25.0559937513	-1995.68574625	131000	-131000	-9.38988900229	-131000