HotNet pathway analysis of mutation and copy number data
Lung Squamous Cell Carcinoma (Primary solid tumor)
23 May 2013  |  analyses__2013_05_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang (Broad Institute)
Cite as Broad Institute TCGA Genome Data Analysis Center (2013): HotNet pathway analysis of mutation and copy number data. Broad Institute of MIT and Harvard. doi:10.7908/C19C6VGJ
- Overview
+ Introduction
- Summary

There were 94 significant subnetworks identified in HotNet analysis.

- Results
- Significant subnetworks

HotNet identifies 94 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.

Table 1.  Get Full Table Top 10 out of 94 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.

Network No.ofgenes p-value RepeatTimes
GPLD1(47),ALPPL2(55),ALPP(56) 3 0 5
PANX1(50),EMP3(45),P2RX7(28) 3 0 5
CCNL2(80),CDK11B(79),TH(90) 3 0 4
CD53(82),CD58(80),CD2(80) 3 0 4
CD81(90),CD151(89),PTGFRN(81) 3 0 4
EXOC2(48),EXOC3(141),EXOC7(88) 3 0 4
LAPTM5(79),ANKRD13A(28),DCUN1D1(168) 3 0 4
RERE(80),HSPG2(85),ECM1(98) 3 0 4
RPS19(45),C5AR1(47),GPR77(46) 3 0 4
TRIP12(64),CLSTN1(80),APBA2(68) 3 0 4
+ Methods & Data