Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.449 0.295 -9999.0 0.0 -0.714 159.0 159.0 IHH -0.492 0.393 -9999.0 0.0 -0.831 198.0 198.0 SHH Np/Cholesterol/GAS1 -0.078 0.176 -9999.0 0.0 -0.46 59.0 59.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.078 0.174 0.456 59.0 -9999.0 0.0 59.0 SMO/beta Arrestin2 -0.378 0.254 -9999.0 0.0 -0.613 168.0 168.0 SMO -0.399 0.275 -9999.0 0.0 -0.618 201.0 201.0 AKT1 -0.157 0.109 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.392 0.27 -9999.0 0.0 -0.607 201.0 201.0 STIL -0.348 0.254 -9999.0 0.0 -0.552 183.0 183.0 DHH N/PTCH2 -0.052 0.169 -9999.0 0.0 -0.587 31.0 31.0 DHH N/PTCH1 -0.384 0.247 -9999.0 0.0 -0.594 176.0 176.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.059 0.204 -9999.0 0.0 -0.76 27.0 27.0 PTHLH -0.609 0.361 -9999.0 0.0 -0.955 159.0 159.0 determination of left/right symmetry -0.392 0.27 -9999.0 0.0 -0.607 201.0 201.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.601 0.354 -9999.0 0.0 -0.941 159.0 159.0 IHH N/Hhip -0.677 0.384 -9999.0 0.0 -0.84 279.0 279.0 DHH N/Hhip -0.421 0.306 -9999.0 0.0 -0.616 237.0 237.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.392 0.27 -9999.0 0.0 -0.607 201.0 201.0 pancreas development -0.503 0.359 -9999.0 0.0 -0.758 230.0 230.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.013 0.099 -9999.0 0.0 -0.76 6.0 6.0 somite specification -0.392 0.27 -9999.0 0.0 -0.607 201.0 201.0 SHH Np/Cholesterol/PTCH1 -0.372 0.26 -9999.0 0.0 -0.583 181.0 181.0 SHH Np/Cholesterol/PTCH2 -0.077 0.171 -9999.0 0.0 -0.461 54.0 54.0 SHH Np/Cholesterol/Megalin -0.314 0.284 -9999.0 0.0 -0.524 208.0 208.0 SHH -0.073 0.214 -9999.0 0.0 -0.565 55.0 55.0 catabolic process -0.389 0.256 -9999.0 0.0 -0.59 201.0 201.0 SMO/Vitamin D3 -0.392 0.273 -9999.0 0.0 -0.616 181.0 181.0 SHH Np/Cholesterol/Hhip -0.371 0.271 -9999.0 0.0 -0.523 246.0 246.0 LRP2 -0.409 0.379 -9999.0 0.0 -0.76 187.0 187.0 receptor-mediated endocytosis -0.529 0.322 -9999.0 0.0 -0.75 206.0 206.0 SHH Np/Cholesterol/BOC -0.07 0.163 -9999.0 0.0 -0.444 55.0 55.0 SHH Np/Cholesterol/CDO -0.077 0.169 -9999.0 0.0 -0.446 60.0 60.0 mesenchymal cell differentiation 0.367 0.268 0.518 246.0 -9999.0 0.0 246.0 mol:Vitamin D3 -0.371 0.268 -9999.0 0.0 -0.589 181.0 181.0 IHH N/PTCH2 -0.323 0.278 -9999.0 0.0 -0.559 198.0 198.0 CDON -0.011 0.091 -9999.0 0.0 -0.76 5.0 5.0 IHH N/PTCH1 -0.395 0.26 -9999.0 0.0 -0.599 201.0 201.0 Megalin/LRPAP1 -0.31 0.287 -9999.0 0.0 -0.576 187.0 187.0 PTCH2 -0.011 0.087 -9999.0 0.0 -0.729 5.0 5.0 SHH Np/Cholesterol -0.072 0.166 -9999.0 0.0 -0.452 55.0 55.0 PTCH1 -0.391 0.257 -9999.0 0.0 -0.593 201.0 201.0 HHIP -0.504 0.359 -9999.0 0.0 -0.76 230.0 230.0