Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TRIM48	14 (6%)	206	0.25197	1	0.32224	1	0.40971	1	0.10928	1	0.12644	1	0.19171	1	0.090691	1	1	1
PGM5	22 (10%)	198	0.00138	0.237	4.2751e-05	0.00804	0.0063476	1	0.0016404	0.279	0.012615	1	0.0039802	0.665	0.20797	1	0.16842	1
KRAS	25 (11%)	195	0.0087308	1	0.12711	1	0.35107	1	0.12847	1	0.84952	1	0.95979	1	0.17928	1	0.67367	1
CBWD1	28 (13%)	192	0.00014924	0.027	1.7942e-06	0.000348	0.00085719	0.15	7.4848e-05	0.0139	2.3566e-05	0.0045	0.00027367	0.049	0.077989	1	0.026704	1
TP53	99 (45%)	121	4.3316e-09	8.49e-07	3.1827e-05	0.00605	7.7401e-05	0.0143	0.0038126	0.641	6.4018e-06	0.00124	9.1176e-06	0.00175	0.070411	1	9.4049e-05	0.0173
PIK3CA	48 (22%)	172	0.00010814	0.0198	1.8289e-09	3.6e-07	0.00058049	0.103	1.3721e-07	2.68e-05	0.024523	1	0.011851	1	0.00036744	0.0654	0.0047079	0.777
ARID1A	41 (19%)	179	0.00021478	0.0387	0.00656	1	3.5164e-05	0.00665	0.00013069	0.0238	0.019805	1	0.01285	1	0.76129	1	0.31201	1
SMAD4	19 (9%)	201	0.64811	1	0.96329	1	0.052432	1	0.22635	1	0.25815	1	0.16012	1	0.94038	1	0.46233	1
RHOA	13 (6%)	207	0.14169	1	0.18936	1	0.82909	1	0.60362	1	0.10556	1	0.2834	1	0.00059383	0.105	0.29687	1
MXRA8	11 (5%)	209	0.11793	1	0.023186	1	0.090889	1	0.039374	1	0.15291	1	0.009488	1	0.42814	1	0.063465	1
IRF2	15 (7%)	205	0.090572	1	0.23319	1	0.43427	1	0.029733	1	0.0010179	0.176	0.012454	1	0.13543	1	0.24915	1
CDH1	18 (8%)	202	0.25221	1	0.45846	1	0.031361	1	0.0056448	0.92	0.11022	1	0.087563	1	0.27837	1	0.11356	1
PTEN	14 (6%)	206	0.0057033	0.924	0.015187	1	0.0015497	0.265	0.045167	1	0.026997	1	0.039659	1	0.10034	1	0.057507	1
B2M	8 (4%)	212	0.02575	1	0.023186	1	0.032945	1	0.096781	1	0.10812	1	0.28708	1	0.42814	1	0.063465	1
FBXW7	19 (9%)	201	0.083326	1	0.021979	1	0.015691	1	0.29227	1	0.10152	1	0.016912	1	0.023823	1	0.081223	1
PTH2	4 (2%)	216	1	1	0.68655	1	0.28073	1	0.47191	1	0.67171	1	1	1	1	1	1	1
FAM46D	6 (3%)	214	1	1	0.70832	1	0.22184	1	0.63598	1	0.55977	1	0.76743	1	1	1	0.73083	1
RNF43	9 (4%)	211	0.1751	1	0.59562	1	0.20194	1	0.525	1	0.33788	1	0.16682	1	0.52092	1	0.45018	1
APC	33 (15%)	187	0.96989	1	0.020711	1	0.10155	1	0.031848	1	0.00095638	0.166	0.012919	1	0.027207	1	0.0048962	0.803
MAP2K7	14 (6%)	206	0.0058251	0.938	0.098363	1	0.40958	1	0.51002	1	0.13311	1	0.17116	1	0.33006	1	0.052047	1
WSB2	7 (3%)	213	0.34076	1	0.13079	1	0.21497	1	0.039374	1	0.10345	1	0.091328	1	0.024358	1	0.0094142	1
BCOR	16 (7%)	204	0.015604	1	6.6674e-05	0.0125	0.0044981	0.747	0.056076	1	0.0082058	1	0.0033579	0.567	0.18255	1	0.025876	1
C13ORF33	6 (3%)	214	0.36418	1	0.016515	1	0.24283	1	0.40702	1	0.076828	1	0.32436	1	0.27439	1	0.45018	1
TRPS1	30 (14%)	190	0.64014	1	0.039676	1	0.023307	1	0.23977	1	0.032743	1	0.86617	1	0.37833	1	0.58261	1
IAPP	4 (2%)	216	0.8397	1	NA	NA	0.76335	1	0.25675	1	0.44885	1	0.81592	1	NA	NA	NA	NA