Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	15.0	120.0	8.0	-0.125	0.054	1000.0	-1000.0	-0.003	-1000.0
PLK2 and PLK4 events	12.0	36.0	3.0	-0.101	0.01	1000.0	-1000.0	-0.0	-1000.0
HIF-1-alpha transcription factor network	12.0	928.0	76.0	-0.402	0.026	1000.0	-1000.0	-0.051	-1000.0
Syndecan-1-mediated signaling events	10.0	340.0	34.0	-0.155	0.018	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by the Hedgehog family	9.0	512.0	52.0	-0.239	0.074	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	9.0	705.0	78.0	-0.274	0.111	1000.0	-1000.0	-0.032	-1000.0
Ephrin B reverse signaling	8.0	404.0	48.0	-0.221	0.037	1000.0	-1000.0	-0.024	-1000.0
Glypican 1 network	7.0	344.0	48.0	-0.109	0.022	1000.0	-1000.0	-0.015	-1000.0
IGF1 pathway	7.0	417.0	57.0	-0.115	0.048	1000.0	-1000.0	-0.053	-1000.0
IL23-mediated signaling events	7.0	448.0	60.0	-0.481	0.017	1000.0	-1000.0	-0.041	-1000.0
IL12-mediated signaling events	6.0	576.0	87.0	-0.328	0.029	1000.0	-1000.0	-0.094	-1000.0
Osteopontin-mediated events	6.0	239.0	38.0	-0.138	0.017	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	6.0	163.0	26.0	-0.091	0.019	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	6.0	552.0	91.0	-0.617	0.401	1000.0	-1000.0	-0.134	-1000.0
Nectin adhesion pathway	6.0	391.0	63.0	-0.146	0.032	1000.0	-1000.0	-0.042	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	628.0	93.0	-0.112	0.026	1000.0	-1000.0	-0.043	-1000.0
Wnt signaling	6.0	46.0	7.0	-0.091	0.004	1000.0	-1000.0	-0.01	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	6.0	444.0	68.0	-0.302	0.159	1000.0	-1000.0	-0.053	-1000.0
Plasma membrane estrogen receptor signaling	6.0	568.0	86.0	-0.19	0.175	1000.0	-1000.0	-0.057	-1000.0
FOXM1 transcription factor network	6.0	356.0	51.0	-0.437	0.018	1000.0	-1000.0	-0.134	-1000.0
FOXA2 and FOXA3 transcription factor networks	5.0	234.0	46.0	-0.197	0.053	1000.0	-1000.0	-0.051	-1000.0
BMP receptor signaling	5.0	412.0	81.0	-0.19	0.037	1000.0	-1000.0	-0.06	-1000.0
Endothelins	5.0	497.0	96.0	-0.209	0.018	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	5.0	39.0	7.0	-0.091	0.062	1000.0	-1000.0	-0.005	-1000.0
Caspase cascade in apoptosis	4.0	309.0	74.0	-0.059	0.047	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	4.0	220.0	47.0	-0.125	0.046	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	198.0	44.0	-0.102	0.017	1000.0	-1000.0	-0.016	-1000.0
EPHB forward signaling	4.0	394.0	85.0	-0.099	0.063	1000.0	-1000.0	-0.052	-1000.0
Glypican 2 network	4.0	18.0	4.0	-0.028	-0.0	1000.0	-1000.0	-0.0	-1000.0
Nongenotropic Androgen signaling	4.0	252.0	52.0	-0.105	0.051	1000.0	-1000.0	-0.032	-1000.0
IL27-mediated signaling events	4.0	227.0	51.0	-0.19	0.082	1000.0	-1000.0	-0.042	-1000.0
LPA receptor mediated events	4.0	498.0	102.0	-0.147	0.018	1000.0	-1000.0	-0.049	-1000.0
IL6-mediated signaling events	4.0	313.0	75.0	-0.099	0.04	1000.0	-1000.0	-0.034	-1000.0
Syndecan-4-mediated signaling events	4.0	327.0	67.0	-0.123	0.026	1000.0	-1000.0	-0.024	-1000.0
Visual signal transduction: Rods	4.0	223.0	52.0	-0.117	0.036	1000.0	-1000.0	-0.043	-1000.0
LPA4-mediated signaling events	3.0	40.0	12.0	-0.02	0.01	1000.0	-1000.0	-0.008	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	408.0	136.0	-0.427	0.091	1000.0	-1000.0	-0.022	-1000.0
Coregulation of Androgen receptor activity	3.0	229.0	76.0	-0.158	0.036	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	3.0	353.0	105.0	-0.095	0.045	1000.0	-1000.0	-0.044	-1000.0
Syndecan-2-mediated signaling events	3.0	222.0	69.0	-0.097	0.033	1000.0	-1000.0	-0.013	-1000.0
Cellular roles of Anthrax toxin	3.0	117.0	39.0	-0.075	0.017	1000.0	-1000.0	-0.013	-1000.0
Signaling events mediated by PTP1B	3.0	238.0	76.0	-0.195	0.036	1000.0	-1000.0	-0.033	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	204.0	61.0	-0.168	0.052	1000.0	-1000.0	-0.02	-1000.0
p75(NTR)-mediated signaling	3.0	447.0	125.0	-0.162	0.05	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	3.0	154.0	44.0	-0.142	0.03	1000.0	-1000.0	-0.009	-1000.0
amb2 Integrin signaling	3.0	262.0	82.0	-0.087	0.025	1000.0	-1000.0	-0.038	-1000.0
Ceramide signaling pathway	3.0	279.0	76.0	-0.103	0.038	1000.0	-1000.0	-0.02	-1000.0
TRAIL signaling pathway	3.0	180.0	48.0	-0.044	0.017	1000.0	-1000.0	-0.015	-1000.0
IL1-mediated signaling events	3.0	241.0	62.0	-0.08	0.044	1000.0	-1000.0	-0.048	-1000.0
HIF-2-alpha transcription factor network	3.0	132.0	43.0	-0.073	0.036	1000.0	-1000.0	-0.043	-1000.0
S1P1 pathway	3.0	136.0	36.0	-0.122	0.017	1000.0	-1000.0	-0.042	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	48.0	15.0	-0.032	0.018	1000.0	-1000.0	-0.009	-1000.0
Syndecan-3-mediated signaling events	3.0	113.0	35.0	-0.123	0.041	1000.0	-1000.0	-0.019	-1000.0
Integrins in angiogenesis	3.0	288.0	84.0	-0.114	0.033	1000.0	-1000.0	-0.051	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	163.0	45.0	-0.088	0.017	1000.0	-1000.0	-0.055	-1000.0
Canonical Wnt signaling pathway	3.0	203.0	51.0	-0.168	0.1	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by STAT5	3.0	69.0	22.0	-0.093	0.023	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events	3.0	228.0	73.0	-0.052	0.032	1000.0	-1000.0	-0.028	-1000.0
VEGFR1 specific signals	3.0	187.0	56.0	-0.038	0.017	1000.0	-1000.0	-0.021	-1000.0
Regulation of Androgen receptor activity	3.0	257.0	70.0	-0.208	0.024	1000.0	-1000.0	-0.032	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	59.0	17.0	-0.045	0.025	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Cones	2.0	113.0	38.0	-0.044	0.023	1000.0	-1000.0	-0.008	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	48.0	17.0	-0.044	0.017	1000.0	-1000.0	-0.013	-1000.0
a4b1 and a4b7 Integrin signaling	2.0	14.0	5.0	-0.01	0.01	1000.0	-1000.0	-0.002	-1000.0
Arf6 signaling events	2.0	140.0	62.0	-0.028	0.018	1000.0	-1000.0	-0.012	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	193.0	65.0	-0.402	0.047	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	2.0	285.0	97.0	-0.103	0.029	1000.0	-1000.0	-0.043	-1000.0
PLK1 signaling events	2.0	176.0	85.0	-0.042	0.025	1000.0	-1000.0	-0.024	-1000.0
mTOR signaling pathway	2.0	115.0	53.0	-0.038	0.03	1000.0	-1000.0	-0.037	-1000.0
IFN-gamma pathway	2.0	195.0	68.0	-0.063	0.026	1000.0	-1000.0	-0.051	-1000.0
Glucocorticoid receptor regulatory network	2.0	330.0	114.0	-0.251	0.139	1000.0	-1000.0	-0.044	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	85.0	37.0	-0.038	0.026	1000.0	-1000.0	-0.015	-1000.0
Signaling events mediated by HDAC Class III	2.0	93.0	40.0	-0.059	0.043	1000.0	-1000.0	-0.01	-1000.0
Reelin signaling pathway	2.0	153.0	56.0	-0.047	0.041	1000.0	-1000.0	-0.045	-1000.0
Signaling events regulated by Ret tyrosine kinase	2.0	170.0	82.0	-0.051	0.024	1000.0	-1000.0	-0.049	-1000.0
ceramide signaling pathway	2.0	140.0	49.0	-0.06	0.02	1000.0	-1000.0	-0.017	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	107.0	52.0	-0.126	0.043	1000.0	-1000.0	-0.023	-1000.0
Retinoic acid receptors-mediated signaling	2.0	152.0	58.0	-0.108	0.045	1000.0	-1000.0	-0.045	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	72.0	36.0	-0.038	0.035	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	2.0	163.0	58.0	-0.127	0.019	1000.0	-1000.0	-0.055	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	78.0	31.0	-0.095	0.02	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	317.0	125.0	-0.04	0.03	1000.0	-1000.0	-0.059	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	189.0	74.0	-0.103	0.039	1000.0	-1000.0	-0.053	-1000.0
BCR signaling pathway	2.0	243.0	99.0	-0.065	0.04	1000.0	-1000.0	-0.049	-1000.0
EGFR-dependent Endothelin signaling events	2.0	50.0	21.0	-0.042	0.026	1000.0	-1000.0	-0.04	-1000.0
PDGFR-beta signaling pathway	2.0	204.0	97.0	-0.055	0.044	1000.0	-1000.0	-0.045	-1000.0
Signaling events mediated by PRL	2.0	83.0	34.0	-0.073	0.026	1000.0	-1000.0	-0.016	-1000.0
E-cadherin signaling in keratinocytes	2.0	93.0	43.0	-0.037	0.021	1000.0	-1000.0	-0.015	-1000.0
Aurora B signaling	2.0	153.0	67.0	-0.061	0.021	1000.0	-1000.0	-0.04	-1000.0
Canonical NF-kappaB pathway	1.0	59.0	39.0	-0.036	0.043	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class II	1.0	106.0	75.0	-0.099	0.04	1000.0	-1000.0	-0.029	-1000.0
BARD1 signaling events	1.0	95.0	57.0	-0.055	0.041	1000.0	-1000.0	-0.026	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	41.0	28.0	-0.05	0.026	1000.0	-1000.0	-0.011	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	95.0	54.0	-0.085	0.048	1000.0	-1000.0	-0.057	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.0	0.019	1000.0	-1000.0	-0.004	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	141.0	85.0	-0.144	0.049	1000.0	-1000.0	-0.041	-1000.0
Aurora A signaling	1.0	111.0	60.0	-0.04	0.039	1000.0	-1000.0	-0.007	-1000.0
Arf6 downstream pathway	1.0	56.0	43.0	-0.022	0.026	1000.0	-1000.0	-0.016	-1000.0
EPO signaling pathway	1.0	96.0	55.0	-0.082	0.035	1000.0	-1000.0	-0.043	-1000.0
S1P5 pathway	1.0	24.0	17.0	-0.05	0.017	1000.0	-1000.0	-0.01	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	154.0	83.0	-0.079	0.052	1000.0	-1000.0	-0.023	-1000.0
FoxO family signaling	1.0	79.0	64.0	-0.057	0.061	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	1.0	50.0	31.0	-0.038	0.03	1000.0	-1000.0	-0.013	-1000.0
Regulation of p38-alpha and p38-beta	1.0	83.0	54.0	-0.058	0.041	1000.0	-1000.0	-0.035	-1000.0
TCGA08_rtk_signaling	1.0	38.0	26.0	-0.038	0.052	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	135.0	76.0	-0.038	0.035	1000.0	-1000.0	-0.048	-1000.0
Regulation of Telomerase	1.0	190.0	102.0	-0.099	0.047	1000.0	-1000.0	-0.066	-1000.0
Insulin Pathway	1.0	136.0	74.0	-0.099	0.054	1000.0	-1000.0	-0.05	-1000.0
S1P3 pathway	1.0	70.0	42.0	-0.048	0.026	1000.0	-1000.0	-0.022	-1000.0
Angiopoietin receptor Tie2-mediated signaling	1.0	127.0	88.0	-0.099	0.045	1000.0	-1000.0	-0.057	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	54.0	33.0	-0.132	0.049	1000.0	-1000.0	-0.02	-1000.0
Rapid glucocorticoid signaling	1.0	20.0	20.0	-0.006	0.017	1000.0	-1000.0	-0.003	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	218.0	120.0	-0.065	0.052	1000.0	-1000.0	-0.046	-1000.0
S1P4 pathway	1.0	29.0	25.0	-0.05	0.026	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	1.0	9.0	5.0	0.002	0.021	1000.0	-1000.0	-0.0	-1000.0
p38 MAPK signaling pathway	1.0	87.0	44.0	-0.04	0.034	1000.0	-1000.0	-0.048	-1000.0
ErbB2/ErbB3 signaling events	0.0	58.0	65.0	-0.042	0.04	1000.0	-1000.0	-0.039	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	20.0	23.0	-0.014	0.037	1000.0	-1000.0	-0.016	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	0.0	32.0	34.0	-0.014	0.04	1000.0	-1000.0	-0.011	-1000.0
ErbB4 signaling events	0.0	64.0	69.0	-0.058	0.05	1000.0	-1000.0	-0.057	-1000.0
Circadian rhythm pathway	0.0	16.0	22.0	-0.024	0.044	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.021	1000.0	-1000.0	-0.006	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.057	0.036	1000.0	-1000.0	-0.012	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	44.0	68.0	-0.057	0.05	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	0.0	94.0	104.0	-0.052	0.045	1000.0	-1000.0	-0.026	-1000.0
Effects of Botulinum toxin	0.0	15.0	26.0	-0.02	0.036	1000.0	-1000.0	-0.015	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.006	0.042	1000.0	-1000.0	-0.034	-1000.0
Arf6 trafficking events	0.0	26.0	71.0	-0.032	0.042	1000.0	-1000.0	-0.039	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.017	0.017	1000.0	-1000.0	-0.003	-1000.0
Arf1 pathway	0.0	2.0	54.0	-0.002	0.037	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	6.0	13.0	-0.0	0.044	1000.0	-1000.0	-0.004	-1000.0
Total	381	24513	7203	-13.8165449518	5.3405760665	131000	-131000	-4.11291721422	-131000