rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(6)	239708	6	5	6	0	4	1	0	0	1	0	0.146	0.0432	1.000
2	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(1), CASP3(2), CASP8(11), CFL1(1), CFLAR(3), PDE6D(1)	1235944	19	17	18	2	3	7	5	0	4	0	0.110	0.0721	1.000
3	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(4), ALDOA(1), ALDOB(5), ALDOC(3), TPI1(1)	1203129	14	13	14	1	4	7	3	0	0	0	0.0768	0.131	1.000
4	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), LTB4R(1), P2RY1(6), P2RY2(3), P2RY6(1)	1769574	28	20	28	4	12	11	3	1	1	0	0.0110	0.279	1.000
5	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(4), CYP2C9(7)	660768	11	9	11	2	3	3	4	0	1	0	0.506	0.321	1.000
6	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(37), CDC25A(2), CDC25B(5), CDC25C(4), CHEK1(1), MYT1(13), WEE1(3), YWHAH(1)	4495368	66	37	64	7	13	30	10	1	10	2	0.00648	0.345	1.000
7	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(4), LIPT1(4)	492074	8	6	8	1	0	6	1	0	1	0	0.580	0.351	1.000
8	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(6), BCMO1(4), RDH5(1)	1251009	15	13	15	2	6	4	4	0	1	0	0.164	0.352	1.000
9	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(4), TPI1(1)	498985	5	5	5	0	0	2	3	0	0	0	0.274	0.376	1.000
10	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(7), ERBB4(21), NRG2(6), NRG3(7), PRKCA(4), PSEN1(3)	2961197	48	31	47	9	11	19	9	2	7	0	0.0736	0.427	1.000
11	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GPX1(1), PRKCE(6)	2339973	47	28	45	7	14	22	6	0	5	0	0.0102	0.501	1.000
12	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(4), FMOD(2), KERA(7), LUM(6)	1154038	20	16	20	4	7	4	7	0	2	0	0.273	0.543	1.000
13	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), BCKDK(3), CBS(3), CTH(2), MUT(4)	1600942	13	11	13	1	5	4	0	0	4	0	0.130	0.606	1.000
14	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(4), HLA-DRA(5), HLA-DRB1(2), IL3(3)	945594	14	12	13	4	7	5	0	0	0	2	0.432	0.620	1.000
15	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(2), CD4(2), HLA-DRA(5), HLA-DRB1(2)	742459	11	9	11	4	4	5	0	0	0	2	0.616	0.723	1.000
16	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(3), EGFR(11), ERBB3(14), NRG1(15), UBE2D1(1)	3364804	44	33	40	7	18	8	11	1	6	0	0.0453	0.736	1.000
17	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1), CD3G(2)	383144	3	2	3	1	1	1	0	0	1	0	0.717	0.745	1.000
18	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CDK2(2), CDKN1B(3), CKS1B(1), CUL1(8), NEDD8(1), RB1(7), RBX1(1), SKP2(1), TFDP1(4)	2830382	31	24	31	7	7	4	10	1	8	1	0.263	0.762	1.000
19	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(6), SPCS1(1), SPCS3(1)	990423	10	9	8	3	6	1	1	0	2	0	0.416	0.793	1.000
20	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(1), TAT(5)	869667	12	8	11	2	4	5	1	0	2	0	0.264	0.815	1.000
21	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(37), ATR(17), CDC25C(4), CHEK1(1), CHEK2(1), YWHAH(1)	5020369	61	32	60	7	13	28	7	0	11	2	0.0461	0.826	1.000
22	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(11), AKT1(2), ATM(37), BAX(1), CDKN1A(1), CPB2(2), CSNK1A1(2), CSNK1D(4), FHL2(2), HIF1A(3), IGFBP3(4), MAPK8(7), MDM2(4), NFKBIB(1), NQO1(1)	6309655	82	38	81	8	15	32	20	2	11	2	0.000602	0.854	1.000
23	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(4), BMPR1A(4), BMPR1B(10), BMPR2(9)	2005223	27	17	27	5	6	6	8	0	7	0	0.226	0.873	1.000
24	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(2), IL8(1)	521195	3	3	3	3	0	2	0	0	1	0	0.939	0.886	1.000
25	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(5)	671685	7	7	7	3	3	3	0	0	1	0	0.720	0.888	1.000
26	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GSS(4), GSTA1(1), GSTA3(4), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1)	5663811	63	34	61	9	13	28	16	0	6	0	0.00678	0.895	1.000
27	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(2), B3GNT1(2), FUT1(4), FUT2(1), FUT9(5), GCNT2(11), ST8SIA1(3)	1927369	28	18	28	7	10	9	5	0	4	0	0.183	0.909	1.000
28	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), TGDS(1), UGDH(4), UXS1(7)	1211336	15	12	15	4	5	6	2	0	2	0	0.502	0.922	1.000
29	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2782266	30	24	30	8	14	10	4	0	2	0	0.263	0.925	1.000
30	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(3), AKR1D1(1), CYP11A1(4), CYP11B1(9), CYP11B2(5), CYP17A1(2), CYP21A2(1), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2782266	30	24	30	8	14	10	4	0	2	0	0.263	0.925	1.000
31	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(5), GPD2(4), NDUFA1(1), SDHA(6), SDHB(2), SDHD(1), UQCRC1(2)	2055348	21	15	21	3	6	11	3	0	1	0	0.137	0.936	1.000
32	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(3), CDK2(2), CUL1(8), RB1(7), TFDP1(4)	2241819	24	18	24	6	5	3	9	1	5	1	0.357	0.936	1.000
33	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(2)	577959	6	5	6	2	2	2	1	0	1	0	0.651	0.943	1.000
34	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(1), CSF1(2), IL6(2), LDLR(5), LPL(6)	1698278	16	12	16	4	6	4	4	0	2	0	0.341	0.947	1.000
35	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(3), COQ6(2), COQ7(1), NDUFA12(2), NDUFA13(1)	1309252	9	8	9	2	1	4	2	0	2	0	0.639	0.947	1.000
36	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(3), NFYB(1), NFYC(3), RB1(7), SP1(2), SP3(3)	2195128	19	15	19	4	4	8	5	0	1	1	0.411	0.951	1.000
37	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(37), CDC25A(2), CDC25B(5), CDC25C(4), CDK2(2), CDK4(3), CHEK1(1), MYT1(13), RB1(7), WEE1(3), YWHAH(1)	5515568	78	42	76	10	16	32	14	2	11	3	0.0133	0.952	1.000
38	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2), RAB9A(1)	1339280	13	9	13	2	4	6	2	0	1	0	0.232	0.955	1.000
39	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(2), GRIA2(13), PPP1R1B(1)	1155751	16	13	15	5	7	3	5	0	1	0	0.416	0.957	1.000
40	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(3), AASS(9), KARS(3)	1561749	16	13	16	4	4	4	5	0	3	0	0.559	0.963	1.000
41	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD3G(2), CD4(2), FYN(5), HLA-DRA(5), HLA-DRB1(2), LCK(3), PTPRC(17), ZAP70(4)	2919089	41	22	41	9	10	16	6	0	7	2	0.156	0.965	1.000
42	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	16	CD28(2), CD3D(1), CD3G(2), CD80(1), CTLA4(2), GRB2(3), HLA-DRA(5), HLA-DRB1(2), ICOS(1), IL2(4), ITK(11), LCK(3), PIK3R1(10), PTPN11(5)	3410038	52	30	50	10	15	19	7	0	7	4	0.104	0.965	1.000
43	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(2), CD4(2), CD80(1), HLA-DRA(5), HLA-DRB1(2), IL10(2), IL2(4), IL4(3)	1272920	21	13	21	8	8	11	0	0	0	2	0.618	0.968	1.000
44	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(2), GSTZ1(2), HGD(2)	556538	6	5	6	4	1	2	2	0	1	0	0.880	0.972	1.000
45	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS1(2), PAPSS2(4), SULT1A2(1), SULT1E1(2), SULT2A1(2), SUOX(2)	1960765	14	8	14	1	5	5	1	0	3	0	0.149	0.973	1.000
46	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), TGDS(1), UGDH(4), UGP2(7), UXS1(7)	1558718	22	16	22	5	7	8	4	0	3	0	0.385	0.976	1.000
47	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(2), RANBP1(1), RANBP2(16), RANGAP1(1)	2408839	20	12	19	4	5	5	6	0	4	0	0.286	0.979	1.000
48	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(1), ACAT2(2), ACYP1(2), ECHS1(2), EHHADH(2), GCDH(5), HADHA(3), SDHB(2), SDS(2)	2521582	21	13	21	3	6	7	2	1	5	0	0.0926	0.981	1.000
49	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6)	1755757	24	19	24	9	3	9	11	0	1	0	0.627	0.983	1.000
50	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(6), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2)	3224857	30	19	29	7	11	9	6	0	4	0	0.292	0.984	1.000
51	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(1), ACAT2(2), HMGCL(1), OXCT1(3)	1107608	7	7	7	3	2	4	1	0	0	0	0.783	0.989	1.000
52	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(6), CCNE1(3), CDK2(2), CUL1(8), RB1(7), SKP2(1), TFDP1(4)	2888366	31	22	31	8	7	5	11	1	6	1	0.317	0.989	1.000
53	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5R1(1), EGR1(3), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NGFR(3), RAF1(6)	2522799	26	19	23	7	9	7	6	0	4	0	0.229	0.990	1.000
54	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(3), ITGB1(6), KLRC3(3), KLRC4(1), KLRD1(1), LAT(1), MAP2K1(4), MAPK3(3), PAK1(5), PIK3R1(10), PTK2B(1), PTPN6(4), SYK(3), VAV1(13)	5155475	58	35	57	12	19	13	12	1	11	2	0.0723	0.990	1.000
55	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(3), CHRNA1(4), SNAP25(1), STX1A(2)	1039498	10	10	10	4	6	2	2	0	0	0	0.697	0.991	1.000
56	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CDO1(1), CSAD(2), GAD1(9), GAD2(4), GGT1(3)	1789149	21	17	19	7	8	11	2	0	0	0	0.452	0.991	1.000
57	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(4), CD4(2), HLA-DRA(5), HLA-DRB1(2), IL1B(1), IL4(3), IL5RA(6), IL6(2)	1721899	25	15	24	8	11	12	0	0	0	2	0.404	0.991	1.000
58	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(5), HSD17B2(2), HSD17B3(2), HSD17B4(3), HSD3B1(3), HSD3B2(1)	2646090	18	12	18	4	5	7	4	0	2	0	0.292	0.991	1.000
59	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), CASP8AP2(18), CASP9(2), CES1(5)	3282753	45	28	43	10	13	16	8	0	8	0	0.339	0.992	1.000
60	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(5), FARSA(1), FARSB(8), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2), YARS2(4)	2851016	36	20	35	7	10	13	7	0	6	0	0.115	0.993	1.000
61	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(6), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHB(3), LDHC(2)	2212516	22	15	21	4	9	7	3	0	3	0	0.184	0.993	1.000
62	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(6), ACAT1(1), ECHS1(2), HADHA(3)	1761219	14	9	13	5	2	4	1	0	7	0	0.669	0.993	1.000
63	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	14	ABL1(4), CDKN2A(1), MDM2(4), PIK3R1(10), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), RB1(7)	5404211	48	28	47	9	13	12	14	0	6	3	0.0713	0.993	1.000
64	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(3), AKR1D1(1), ARSB(5), ARSD(3), ARSE(2), CYP11B1(9), CYP11B2(5), HSD11B1(1), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	8511308	76	40	75	13	33	23	9	0	11	0	0.00259	0.994	1.000
65	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(6), CCNA2(3), CCNE1(3), CCNE2(2), CDK2(2), CDK4(3), CDKN1B(3), CDKN2A(1), E2F2(1), E2F4(1), PRB1(1)	2773237	26	20	26	7	7	6	7	1	5	0	0.373	0.994	1.000
66	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(2), CPS1(14), GLUD1(2), GOT1(6)	2474450	25	14	24	6	6	9	4	0	6	0	0.398	0.995	1.000
67	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(3), IFNB1(1), JAK1(4), PTPRU(12), REG1A(5), STAT1(6), STAT2(7), TYK2(1)	3945542	39	27	37	9	22	7	6	0	4	0	0.121	0.995	1.000
68	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(5), GAD1(9), HDC(8), TPH1(3)	1901186	25	19	25	8	9	12	3	0	1	0	0.362	0.995	1.000
69	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(4), B3GNT5(1), FUT1(4), FUT2(1), FUT3(4), ST3GAL3(4), ST3GAL4(2)	2220428	26	16	26	5	13	7	4	0	2	0	0.135	0.996	1.000
70	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	1588567	9	7	9	3	3	2	0	0	4	0	0.580	0.996	1.000
71	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	14	AKT1(2), BAD(1), GRB2(3), IGF1R(8), IRS1(8), MAP2K1(4), MAPK1(2), MAPK3(3), PIK3R1(10), RAF1(6), SHC1(3), SOS1(7), YWHAH(1)	5355537	58	38	55	11	18	17	12	0	9	2	0.0590	0.996	1.000
72	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP14(4), MMP2(5), MMP9(11), RECK(5), TIMP1(2), TIMP2(2), TIMP3(3), TIMP4(2)	2410966	34	22	34	8	19	7	7	0	1	0	0.0830	0.996	1.000
73	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	19	CSNK2A1(4), FOS(1), GRB2(3), IGF1(2), IGF1R(8), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PIK3R1(10), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3)	7200035	83	42	80	14	24	26	19	1	11	2	0.00933	0.996	1.000
74	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDK2(2), CDK4(3), CDKN1A(1), CDKN1B(3), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), PRB1(1)	2213840	18	14	18	5	3	4	6	1	4	0	0.511	0.996	1.000
75	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	2589944	30	22	30	6	15	5	7	0	3	0	0.168	0.996	1.000
76	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), MIOX(1), UGDH(4)	2714521	31	20	31	6	10	12	5	0	4	0	0.0891	0.997	1.000
77	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(9), EGF(3), EGFR(11), TF(11), TFRC(3)	4231813	37	23	37	7	17	9	7	0	3	1	0.0679	0.997	1.000
78	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(6), NR1I3(3), PTGS1(6), PTGS2(3)	1700919	21	17	21	6	9	7	4	0	1	0	0.438	0.997	1.000
79	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), MECR(1), PPT2(2)	2798043	17	14	17	9	3	5	2	0	7	0	0.905	0.998	1.000
80	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(5), PLCD1(7), PRKCA(4), TGM2(6)	1609055	22	14	22	6	9	11	1	0	1	0	0.230	0.998	1.000
81	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1145632	10	10	8	5	2	5	0	0	3	0	0.801	0.998	1.000
82	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(2), BIRC3(7), CASP8(11), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1)	2736593	25	19	24	6	6	8	6	0	5	0	0.251	0.998	1.000
83	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(2), FUT1(4), FUT2(1), FUT3(4), FUT6(1), ST3GAL3(4)	1445359	16	12	16	5	10	4	2	0	0	0	0.387	0.998	1.000
84	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(2), ST6GALNAC4(2), ST8SIA1(3)	1775738	12	11	12	4	2	3	5	0	2	0	0.568	0.998	1.000
85	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(2), CD3D(1), CD3G(2), CD4(2)	933842	8	7	9	5	3	4	0	0	1	0	0.860	0.998	1.000
86	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(7), DLL1(4), FURIN(3), PSEN1(3)	2903462	17	13	17	3	7	2	2	0	6	0	0.114	0.998	1.000
87	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMB8(3), PSMB9(4)	2860412	23	18	23	6	6	7	5	2	3	0	0.375	0.998	1.000
88	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(1), CNR1(5), DNMT1(19), MTNR1B(3), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1)	3549074	39	26	35	8	18	10	7	3	1	0	0.0332	0.998	1.000
89	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(7), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(2), APOBEC3G(3), APOBEC4(4)	2323876	23	16	23	5	9	8	3	1	2	0	0.251	0.998	1.000
90	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(9), AGT(5), AGTR1(5), AGTR2(5), COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), REN(5)	8136031	95	43	94	19	22	33	22	1	17	0	0.00893	0.998	1.000
91	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(5)	2884558	26	23	26	9	9	8	5	0	4	0	0.596	0.998	1.000
92	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(2), MAX(1), SP1(2), SP3(3), WT1(6)	1989859	14	12	14	4	8	3	3	0	0	0	0.322	0.998	1.000
93	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2574752	33	19	33	5	13	12	7	0	1	0	0.0249	0.999	1.000
94	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1)	2574752	33	19	33	5	13	12	7	0	1	0	0.0249	0.999	1.000
95	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	CREB1(1), FOS(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(7), NFE2L2(4), PRKCA(4)	2728479	25	13	25	3	6	10	7	1	1	0	0.0519	0.999	1.000
96	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(3), IDI1(1), SQLE(2)	952281	6	5	6	3	1	2	2	0	1	0	0.865	0.999	1.000
97	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), WASF1(3), WASL(7)	2580413	29	17	29	6	11	9	6	0	3	0	0.145	0.999	1.000
98	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CDC42(1), CHUK(6), MAP2K1(4), MAPK3(3), NFKB1(6), PIK3R1(10), RAF1(6), RALA(1), RALBP1(6), RALGDS(1), RELA(2), RHOA(5)	5490758	57	33	55	11	25	5	15	0	10	2	0.0717	0.999	1.000
99	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(3), GNAQ(4), GNB1(1), GNGT1(1), HTR2C(8), PLCB1(8), TUB(5)	2314792	30	20	30	9	14	5	6	1	4	0	0.421	0.999	1.000
100	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), PER1(1)	2757079	25	14	24	5	8	7	5	0	4	1	0.207	0.999	1.000
101	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	17	CSNK2A1(4), FOS(1), GRB2(3), KLK2(3), MAP2K1(4), MAPK3(3), MAPK8(7), NGFR(3), PIK3R1(10), PLCG1(4), RAF1(6), SHC1(3), SOS1(7)	5423116	58	33	53	10	16	18	14	1	7	2	0.0447	0.999	1.000
102	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(2)	1308898	8	6	8	5	1	3	2	0	2	0	0.933	0.999	1.000
103	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(3), ENO3(4), FARS2(5), GOT1(6), GOT2(1), PAH(4), TAT(5), YARS(2)	2733566	30	19	29	7	8	11	6	0	5	0	0.234	1.000	1.000
104	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), DHFR(1), GGH(1)	1912740	7	7	7	1	2	4	1	0	0	0	0.253	1.000	1.000
105	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(8), ATM(37), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(3), CDKN1A(1), MDM2(4), PCNA(3), RB1(7), TIMP3(3)	5697197	73	38	72	12	13	30	15	1	11	3	0.0556	1.000	1.000
106	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(6), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(8)	3658212	26	19	26	5	6	6	9	0	5	0	0.294	1.000	1.000
107	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(3), IFNGR2(2), JAK1(4), JAK2(9), STAT1(6)	2648708	25	15	24	7	8	6	6	0	3	2	0.513	1.000	1.000
108	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(1), ALAS1(6), ALAS2(6), CPOX(1), FECH(3), HMBS(2), PPOX(3), UROD(1), UROS(1)	2506333	24	15	24	5	13	8	2	0	1	0	0.298	1.000	1.000
109	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(7), PARK2(6), SNCA(1), SNCAIP(3), UBE2E2(1), UBE2F(1), UBE2G1(2), UBE2L3(2)	2084954	23	17	23	8	6	11	5	0	1	0	0.636	1.000	1.000
110	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(6), CARS2(1), CDO1(1), CTH(2), GOT1(6), GOT2(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), SDS(2), SULT1B1(4), SULT1C2(2), SULT1C4(3), SULT4A1(1)	4095848	41	22	38	7	16	14	6	1	4	0	0.0446	1.000	1.000
111	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(8), G6PD(3), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), GSR(1), GSS(4), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), TXNDC12(2)	6794262	70	37	68	11	14	30	19	0	7	0	0.00865	1.000	1.000
112	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(3), CHST12(3), CHST13(2), PAPSS1(2), PAPSS2(4), SULT1A1(2), SULT1A2(1), SULT1E1(2), SULT2A1(2), SULT2B1(1), SUOX(2)	2953653	25	14	25	5	10	8	4	0	3	0	0.171	1.000	1.000
113	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1)	4316814	28	16	28	4	10	9	7	1	1	0	0.0610	1.000	1.000
114	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(6), MAPK14(3), NFATC1(2), NFATC2(5), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	3757504	38	26	38	11	21	8	4	2	3	0	0.0837	1.000	1.000
115	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(2), CCNE1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), MAPK1(2), MAPK3(3), NFKB1(6), PAK1(5), PIK3R1(10), RAF1(6), RB1(7), RELA(2), TFDP1(4)	5885318	60	32	58	12	20	9	15	2	11	3	0.0694	1.000	1.000
116	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	15	AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NFKB1(6), PIK3R1(10), RB1(7), RELA(2), SP1(2)	5600970	60	32	59	13	19	13	14	2	9	3	0.132	1.000	1.000
117	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(4), BIRC3(7), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), DIABLO(1)	4426695	49	30	48	9	12	18	10	0	9	0	0.141	1.000	1.000
118	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(3), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(8), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTR(7)	5629135	70	37	65	15	33	18	6	3	10	0	0.0364	1.000	1.000
119	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(1), ALAS1(6), ALAS2(6), CPO(3), FECH(3), GATA1(5), HBB(3), HMBS(2), UROD(1), UROS(1)	2652144	31	17	30	6	16	12	2	0	1	0	0.121	1.000	1.000
120	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(2), CDKN1B(3), GRB2(3), ITGB1(6), MAPK1(2), MAPK3(3), PDK2(2), PDPK1(1), PIK3R1(10), PTEN(10), PTK2(5), SHC1(3), SOS1(7)	5484402	57	33	53	12	11	15	14	0	14	3	0.230	1.000	1.000
121	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), CSF1(2), IL11(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), IL9(2)	2018290	22	14	21	8	9	10	2	0	1	0	0.584	1.000	1.000
122	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(7), SLC2A1(1), SLC2A3(1)	8005910	79	39	78	20	20	25	16	1	17	0	0.0773	1.000	1.000
123	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(1), FOS(1), FYN(5), MAPK14(3), THBS1(10)	2315988	22	16	22	8	7	10	3	0	2	0	0.564	1.000	1.000
124	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(3), CYP11A1(4), EDN1(1), EDNRA(4), EDNRB(12), HSD11B1(1), PLA2G4A(8), PRL(3), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	6562968	74	37	72	19	30	23	14	0	7	0	0.101	1.000	1.000
125	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA3(3), GGT1(3), SHMT1(2), SHMT2(2)	1596668	10	10	8	8	2	5	0	0	3	0	0.976	1.000	1.000
126	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(1), GLUD1(2), OAT(1)	1708076	7	6	7	3	4	1	2	0	0	0	0.739	1.000	1.000
127	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(2), F13A1(10), F2(3), FGA(13), FGB(2), FGG(4), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3)	4353615	59	33	59	13	19	22	11	0	7	0	0.105	1.000	1.000
128	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(4), GSK3B(8), MAPT(5), PPP2CA(1)	2713718	26	16	26	8	12	5	5	1	3	0	0.362	1.000	1.000
129	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(1), ANKRD1(6), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(5), IL1A(1), IL1R1(4), MYOG(1), NR4A3(4), WDR1(3)	3401246	30	16	30	6	9	11	7	0	3	0	0.156	1.000	1.000
130	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(3), IFNAR2(2), IFNB1(1), JAK1(4), STAT1(6), STAT2(7), TYK2(1)	3410982	25	18	24	6	11	6	5	0	3	0	0.264	1.000	1.000
131	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(2), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALT1(6), B4GALT2(3), B4GALT3(7), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), ST3GAL6(7), ST8SIA1(3)	4981425	61	34	61	14	25	17	12	1	6	0	0.0500	1.000	1.000
132	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CSK(3), GRB2(3), PRKCA(4), PTPRA(2), SRC(3)	3012557	28	23	28	9	7	14	6	1	0	0	0.524	1.000	1.000
133	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	9	CD3D(1), CD3G(2), GZMB(2), HLA-A(3), ICAM1(2), ITGAL(8), ITGB2(5)	2580931	23	17	23	8	7	6	4	0	6	0	0.510	1.000	1.000
134	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), SDS(2)	3942100	42	23	42	8	16	14	7	0	5	0	0.0365	1.000	1.000
135	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	20	CSNK2A1(4), FOS(1), GRB2(3), INSR(6), IRS1(8), MAP2K1(4), MAPK3(3), MAPK8(7), PIK3R1(10), PTPN11(5), RAF1(6), RASA1(9), SHC1(3), SLC2A4(4), SOS1(7), SRF(3)	7445242	83	42	80	18	21	27	20	1	12	2	0.0825	1.000	1.000
136	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(10), CLOCK(8), CRY1(5), CRY2(1), CSNK1D(4), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(9)	5495210	49	27	47	9	20	13	8	2	5	1	0.0222	1.000	1.000
137	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(8), PNPO(1), PSAT1(4)	1576379	13	9	13	5	4	5	2	0	2	0	0.770	1.000	1.000
138	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(5), ABP1(1), ACADL(2), ACADM(6), ACADSB(5), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), MLYCD(1), SDS(2), SMS(2), UPB1(5)	9338115	114	45	113	28	40	41	19	1	13	0	0.0286	1.000	1.000
139	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(4), SEC61A2(1), SRP19(1), SRP54(3), SRP68(4), SRP72(4), SRPR(1)	2426459	18	12	18	5	6	8	2	1	1	0	0.530	1.000	1.000
140	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	11	AKT1(2), GRB2(3), KLK2(3), NTRK1(6), PIK3R1(10), PLCG1(4), PRKCA(4), SHC1(3), SOS1(7)	4327816	42	33	38	10	8	16	9	0	7	2	0.371	1.000	1.000
141	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(9), NTRK1(6), PIR(1), PSMA7(1), WASF1(3), WASF2(2), WASF3(4), WASL(7)	4912337	52	29	52	11	17	17	12	0	6	0	0.113	1.000	1.000
142	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(9), AGT(5), AGTR1(5), AGTR2(5), ANPEP(8), CPA3(3), CTSA(3), CTSG(3), ENPEP(9), LNPEP(8), MAS1(2), MME(10), NLN(3), REN(5)	6852632	80	42	80	17	22	29	19	0	10	0	0.0480	1.000	1.000
143	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(6), GOT2(1), TAT(5), TYR(3)	1542979	16	12	15	7	6	5	3	0	2	0	0.774	1.000	1.000
144	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1), TPK1(3)	2085301	20	15	20	5	8	6	4	0	2	0	0.459	1.000	1.000
145	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(4), FOS(1), MAPK3(3), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4017762	33	23	33	8	16	7	6	1	3	0	0.124	1.000	1.000
146	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), KARS(3)	2292322	20	15	20	8	5	6	6	0	3	0	0.863	1.000	1.000
147	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), GRB2(3), HBXIP(2), PTK2B(1), SHC1(3), SOS1(7), SRC(3)	2850044	20	17	19	7	2	10	5	0	3	0	0.767	1.000	1.000
148	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(1), GNAS(6), GNB1(1), GNGT1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4)	2975834	26	22	26	7	11	9	4	0	2	0	0.326	1.000	1.000
149	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1)	4148583	51	30	51	15	13	20	16	0	2	0	0.268	1.000	1.000
150	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(8), IGF1(2), IGF1R(8), INPPL1(4), PDK2(2), PDPK1(1), PIK3R1(10), PPP2CA(1), PTEN(10), RPS6KB1(3)	5588745	58	35	55	14	20	11	11	0	13	3	0.247	1.000	1.000
151	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), PON1(6)	9073733	112	52	110	25	40	31	28	0	11	2	0.0241	1.000	1.000
152	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(4), MDH1(1), ME1(9), PC(6), PDHA1(5), SLC25A11(1)	2922533	26	23	26	8	12	7	3	0	4	0	0.409	1.000	1.000
153	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	14	CSF2RB(7), FOS(1), GRB2(3), IL3(3), JAK2(9), MAP2K1(4), MAPK3(3), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	5335504	53	28	50	11	20	16	9	0	6	2	0.130	1.000	1.000
154	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(3), ACOX3(7), FADS2(4), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4)	3310244	28	18	27	9	14	4	6	1	3	0	0.450	1.000	1.000
155	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(5), AGTR1(5), AGTR2(5), BDKRB2(3), KNG1(4), NOS3(2), REN(5)	3125352	31	21	30	9	9	10	6	0	6	0	0.375	1.000	1.000
156	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(25), EP300(15), ESR1(12), MAPK1(2), MAPK3(3), PELP1(2), SRC(3)	4627771	62	37	62	15	21	16	15	2	8	0	0.124	1.000	1.000
157	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(4), FOS(1), GRB2(3), IL6(2), IL6R(3), IL6ST(3), JAK1(4), JAK2(9), JAK3(8), MAP2K1(4), MAPK3(3), PTPN11(5), RAF1(6), SHC1(3), SOS1(7), SRF(3), STAT3(2)	7697425	70	37	67	16	22	26	12	0	8	2	0.139	1.000	1.000
158	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(2), ACAA2(1), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), SDS(2)	2732829	17	13	17	7	3	8	2	0	4	0	0.736	1.000	1.000
159	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(8), ARHGAP5(9), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(2), CASP8(11), CASP9(2), GZMB(2)	4064349	41	30	39	10	5	14	10	0	12	0	0.468	1.000	1.000
160	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(2), BCL2(1), BCR(7), CRKL(2), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PIK3R1(10), RAF1(6), SOS1(7), STAT1(6), STAT5B(3)	7849296	79	35	77	15	27	20	19	1	8	4	0.0211	1.000	1.000
161	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP3(2), CASP7(1), DFFA(3), DFFB(2), GZMB(2), HMGB1(1), HMGB2(1), TOP2A(5), TOP2B(9)	2581629	26	14	25	6	4	12	7	0	3	0	0.491	1.000	1.000
162	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PRKACA(1), PRKAR1A(5)	2026105	22	20	22	9	8	7	5	0	2	0	0.767	1.000	1.000
163	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(2), EIF4A2(5), EIF4G1(9), EIF4G2(7), EIF4G3(11), GHR(6), IRS1(8), MAPK1(2), MAPK14(3), MAPK3(3), MKNK1(1), PABPC1(3), PDK2(2), PDPK1(1), PIK3R1(10), PRKCA(4), PTEN(10), RPS6KB1(3)	8270851	90	43	86	21	23	26	20	3	15	3	0.177	1.000	1.000
164	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(6), PLCB1(8), PRKCA(4), RELA(2)	2705298	24	16	24	9	10	6	3	1	4	0	0.670	1.000	1.000
165	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(3), GUSB(2), RPE(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), XYLB(2)	8036272	82	33	81	17	18	33	17	0	14	0	0.0925	1.000	1.000
166	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	4779048	39	27	37	11	15	16	6	1	1	0	0.216	1.000	1.000
167	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3308257	21	16	20	9	8	4	5	0	2	2	0.799	1.000	1.000
168	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(1), IL13RA1(2), IL13RA2(3), IL4R(1), JAK1(4), JAK2(9), TYK2(1)	3308257	21	16	20	9	8	4	5	0	2	2	0.799	1.000	1.000
169	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(3), CYSLTR2(4), GPR161(7), GPR171(4), GPR18(2), GPR34(6), GPR39(3), GPR45(7), GPR65(1), GPR75(2)	3081954	39	23	39	12	17	9	8	0	5	0	0.226	1.000	1.000
170	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(3), DAG1(5), GNAQ(4), ITPKB(4)	1935433	16	11	16	6	5	4	4	0	3	0	0.629	1.000	1.000
171	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), IDS(2), IDUA(1), LCT(20), NAGLU(4)	4667984	48	27	48	13	21	12	10	0	5	0	0.150	1.000	1.000
172	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	4004181	53	30	53	14	16	19	10	0	7	1	0.281	1.000	1.000
173	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(3), ESR1(12), GREB1(12), HSPB2(2), MTA1(1), MTA3(1), PDZK1(1), TUBA8(2)	3294728	35	21	35	10	12	11	6	1	5	0	0.225	1.000	1.000
174	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(2), IL3(3), IL6(2), IL8(1), KITLG(2)	2068841	19	11	18	8	6	9	3	0	1	0	0.718	1.000	1.000
175	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(5), ABP1(1), ACADM(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(14), DPYS(7), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(5)	8669843	99	41	98	28	33	37	16	1	12	0	0.138	1.000	1.000
176	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(1), CYP11A1(4), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(3), HSD3B2(1)	2127702	17	13	17	8	7	7	2	0	1	0	0.732	1.000	1.000
177	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(11), ABCB11(11), ABCB4(11), ABCC1(11), ABCC3(5)	4380608	49	26	49	13	9	18	14	1	7	0	0.269	1.000	1.000
178	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSR(1), GSS(4), IL8(1), NFKB1(6), NOX1(1), RELA(2), XDH(7)	3262588	23	16	23	8	8	6	6	0	3	0	0.597	1.000	1.000
179	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(4), CFL1(1), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), LIMK1(5), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), NOX1(1), PIK3C2G(9), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2(5), RAF1(6), ROCK2(6)	7869153	80	47	78	16	30	21	13	1	15	0	0.0591	1.000	1.000
180	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(4), ATM(37), ATR(17), CCNA1(6), CCNE1(3), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), DHFR(1), GSK3B(8), HDAC1(2), RB1(7), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(9)	9447625	113	49	112	22	29	35	24	1	21	3	0.0252	1.000	1.000
181	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4936085	40	25	39	10	14	14	8	0	4	0	0.258	1.000	1.000
182	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4936085	40	25	39	10	14	14	8	0	4	0	0.258	1.000	1.000
183	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), SHMT1(2)	4936085	40	25	39	10	14	14	8	0	4	0	0.258	1.000	1.000
184	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	34	AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB3(3), CREB5(4), DUSP1(2), DUSP10(5), EEF2K(1), IL1R1(4), MAP2K3(6), MAP2K6(3), MAP3K10(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(3), MYEF2(7), NFKB1(6), NR2C2(4), SRF(3), TRAF6(4)	10684645	105	48	104	26	34	32	21	3	15	0	0.111	1.000	1.000
185	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(4), PRKCA(4), PTK2B(1)	2174018	12	11	12	5	6	3	2	0	1	0	0.678	1.000	1.000
186	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), APEX1(4), CREBBP(25), DFFA(3), DFFB(2), GZMA(3), GZMB(2), HMGB2(1)	3278669	41	25	41	11	12	13	9	0	7	0	0.335	1.000	1.000
187	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(3), GH1(2), GHR(6), IGF1(2), IGF1R(8), PIK3R1(10), SHC1(3), SOD2(4)	3552912	40	29	38	13	16	9	7	0	6	2	0.495	1.000	1.000
188	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(37), ATR(17), BRCA1(6), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(4), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(15), MDM2(4), MYT1(13), PRKDC(18), RPS6KA1(1), WEE1(3), YWHAH(1), YWHAQ(1)	12846831	132	51	130	27	34	51	26	2	17	2	0.0493	1.000	1.000
189	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	3788573	41	22	39	11	9	19	9	0	4	0	0.327	1.000	1.000
190	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(6), DARS(4), EPRS(11), FARS2(5), GARS(3), HARS(2), IARS(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), NARS(3), QARS(8), RARS(4), SARS(2), TARS(6), WARS(2), WARS2(3), YARS(2)	10459404	90	42	90	16	30	25	23	2	10	0	0.0268	1.000	1.000
191	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(9), WEE1(3)	2120487	22	14	21	7	7	8	4	2	1	0	0.697	1.000	1.000
192	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(3), AMD1(1), BHMT(5), CBS(3), CTH(2), DNMT1(19), DNMT3A(8), DNMT3B(8), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), MTAP(1), MTFMT(2), MTR(7), TAT(5)	6652076	79	39	74	18	34	25	6	3	11	0	0.0462	1.000	1.000
193	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	13	AKT1(2), BAD(1), CASP9(2), CHUK(6), GH1(2), GHR(6), NFKB1(6), PDPK1(1), PIK3R1(10), PPP2CA(1), RELA(2), YWHAH(1)	3905036	40	22	39	10	15	7	10	0	6	2	0.358	1.000	1.000
194	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	12	CDH1(5), CREBBP(25), EP300(15), MAP2K1(4), MAP3K7(4), MAPK3(3), SKIL(1), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7)	6486164	83	42	82	21	28	20	19	1	15	0	0.134	1.000	1.000
195	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(1), ATG5(4), ATG7(1), BECN1(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(7), PIK3R4(12), PRKAA1(3), PRKAA2(9), ULK1(1), ULK2(4), ULK3(3)	6669416	72	32	71	17	14	32	20	0	6	0	0.264	1.000	1.000
196	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(3), AKR1D1(1), ARSD(3), ARSE(2), CARM1(2), CYP11B1(9), CYP11B2(5), CYP19A1(8), HSD11B1(1), HSD17B12(2), HSD17B2(2), HSD17B3(2), HSD17B8(1), HSD3B1(3), HSD3B2(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SRD5A1(1), SRD5A2(2), STS(7), SULT1E1(2), SULT2A1(2), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), WBSCR22(1)	15155160	152	62	149	33	44	53	30	2	23	0	0.00710	1.000	1.000
197	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(10), POLR3GL(1), POLR3H(1), POLR3K(1)	7531004	65	35	65	12	25	24	11	1	4	0	0.0248	1.000	1.000
198	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	EPHX2(1), HSD3B7(2), RDH11(1), RDH12(3), RDH13(1)	1530186	8	6	8	4	4	4	0	0	0	0	0.749	1.000	1.000
199	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2)	2248011	18	14	18	6	7	6	3	0	2	0	0.668	1.000	1.000
200	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(5), CDKN1A(1), GRIN1(1), HIF1A(3), JAK2(9), NFKB1(6), RELA(2), SOD2(4)	4111093	31	20	31	9	10	9	5	0	5	2	0.523	1.000	1.000
201	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(5), ACACA(18), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), LDHA(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SDS(2), SUCLA2(5), SUCLG1(2)	10796274	119	45	117	24	42	38	20	1	18	0	0.0126	1.000	1.000
202	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), SOAT2(1), SRD5A1(1), SRD5A2(2)	7415577	80	40	80	23	22	30	23	0	5	0	0.169	1.000	1.000
203	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(1), ALAS1(6), ALAS2(6), BLVRA(2), BLVRB(2), COX10(2), COX15(3), CP(6), CPOX(1), EPRS(11), FECH(3), FTMT(4), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), MMAB(2), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UROD(1), UROS(1)	12896437	128	45	125	28	34	58	23	0	13	0	0.0433	1.000	1.000
204	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(6), EPHB1(9), FYN(5), ITGA1(3), ITGB1(6), L1CAM(4), LYN(4), RAP1B(2), SELP(6)	4815332	49	28	48	14	19	18	8	0	4	0	0.270	1.000	1.000
205	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(6), DNAJC3(1), EIF2S2(1), MAP3K14(3), NFKB1(6), RELA(2)	2815049	19	9	19	7	11	2	4	0	2	0	0.718	1.000	1.000
206	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(5), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(11), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GLS2(2), GLUD1(2), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(6), QARS(8)	10640411	112	43	111	23	36	38	26	2	10	0	0.0158	1.000	1.000
207	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(6), ATIC(4), DHFR(1), GART(3), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	5790428	50	28	49	14	21	17	7	1	4	0	0.203	1.000	1.000
208	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(4), CDK7(1), MNAT1(1), XPO1(2)	2875171	19	14	19	9	6	8	3	1	1	0	0.897	1.000	1.000
209	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), EGF(3), EGFR(11), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	11081947	102	45	98	23	36	28	24	1	11	2	0.0643	1.000	1.000
210	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(5), GNA12(2), GNA13(2), GNAQ(4), GNB1(1), GNGT1(1), MYL2(1), MYLK(14), PLCB1(8), PPP1R12B(9), PRKCA(4), ROCK1(15)	6638083	75	40	73	19	19	22	15	2	17	0	0.305	1.000	1.000
211	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	26	BAG4(2), BIRC2(4), BIRC3(7), CASP3(2), CASP8(11), CFLAR(3), MAP3K3(3), MAP3K7(4), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(6), RIPK1(2), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF2(1)	8455939	67	34	66	14	21	20	17	1	8	0	0.0757	1.000	1.000
212	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH9A1(1), AOX1(8), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HMGCL(1), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), PCCA(9), PCCB(4), SDS(2)	11699341	113	48	112	27	41	41	15	0	16	0	0.0446	1.000	1.000
213	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(18), ACACB(15), FASN(1), MCAT(1), OLAH(1), OXSM(5)	5213871	41	22	40	11	16	13	8	0	4	0	0.232	1.000	1.000
214	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(6), ATIC(4), DHFR(1), FTCD(2), GART(3), MTFMT(2), MTHFD1(6), MTHFD1L(8), MTHFR(7), MTHFS(1), MTR(7), SHMT1(2), SHMT2(2), TYMS(3)	6060258	54	30	53	15	22	18	7	1	6	0	0.206	1.000	1.000
215	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(5), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), NAGLU(4), SPAM1(4)	6540336	72	32	70	19	28	20	15	1	8	0	0.122	1.000	1.000
216	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(2), ACTR3(3), ARPC1A(5), ARPC1B(2), ARPC2(2), CDC42(1), PAK1(5), PDGFRA(17), PIK3R1(10), WASL(7)	3617427	54	22	53	14	14	13	12	1	11	3	0.360	1.000	1.000
217	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(4), ACO1(4), ACO2(2), ACSS1(3), ACSS2(6), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(5)	4312921	37	26	37	12	15	11	6	1	4	0	0.404	1.000	1.000
218	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5R1(1), DAB1(7), FYN(5), LRP8(4), RELN(33), VLDLR(5)	4538438	55	33	53	19	14	21	12	1	7	0	0.596	1.000	1.000
219	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(37), ATR(17), BRCA1(6), BRCA2(22), CHEK1(1), CHEK2(1), FANCA(7), FANCC(3), FANCD2(11), FANCF(2), FANCG(4), HUS1(1), MRE11A(8), RAD1(1), RAD17(4), RAD50(11), TREX1(2)	14031540	138	45	137	19	33	53	28	0	22	2	0.00218	1.000	1.000
220	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(8), GNAS(6), PLCE1(9), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAP2B(1)	4424120	37	27	37	11	15	12	6	0	4	0	0.318	1.000	1.000
221	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), RB1(7), RBL1(5), TFDP1(4)	5110519	46	31	46	12	14	10	13	1	7	1	0.328	1.000	1.000
222	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(2), CREB1(1), CREBBP(25), EP300(15), NCOA3(11), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RXRA(1)	6581423	68	35	68	16	21	22	15	2	8	0	0.105	1.000	1.000
223	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(2), IFNAR1(3), IFNAR2(2), IFNB1(1), MAPK8(7), NFKB1(6), RELA(2), TNFRSF11A(3), TNFSF11(1), TRAF6(4)	3523255	32	17	32	10	12	9	5	1	5	0	0.474	1.000	1.000
224	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(10), AZIN1(2), BTG1(1), CBX3(3), CLOCK(8), CRY1(5), CRY2(1), DNAJA1(2), EIF4G2(7), ETV6(5), GFRA1(8), GSTM3(3), HERPUD1(1), HSPA8(4), IDI1(1), MYF6(2), NCKAP1(9), NCOA4(4), NR1D2(6), PER1(1), PER2(2), PPP1R3C(4), PPP2CB(2), PSMA4(2), SF3A3(1), SUMO3(1), TOB1(2), TUBB3(2), UCP3(2), UGP2(7), ZFR(6)	11796324	114	40	110	22	38	33	27	1	14	1	0.0116	1.000	1.000
225	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), FDXR(1), SHMT1(2)	5217701	41	25	40	11	14	15	8	0	4	0	0.312	1.000	1.000
226	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	6	AKT1(2), PIK3R1(10), PLCB1(8), PLCG1(4), PRKCA(4), VAV1(13)	3495458	41	31	40	12	16	9	7	1	6	2	0.435	1.000	1.000
227	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	26	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), GRB2(3), GSK3A(2), GSK3B(8), IL4R(1), IRS1(8), JAK1(4), JAK3(8), MAP4K1(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PIK3R1(10), PPP1R13B(6), RAF1(6), SHC1(3), SOS1(7), SOS2(11), STAT6(2)	10984288	103	47	99	24	32	30	20	0	19	2	0.0564	1.000	1.000
228	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(4), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADHA(3), HMGCL(1), L2HGDH(3), OXCT1(3), PDHA1(5), PDHA2(8), PDHB(2), SDHB(2), SDS(2)	8414293	95	41	94	25	36	36	15	0	8	0	0.0515	1.000	1.000
229	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), PECAM1(2), SELE(4), SELL(3), SELP(6)	4835640	55	26	53	16	15	24	10	0	6	0	0.324	1.000	1.000
230	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(7), BLNK(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8IP3(2), PAPPA(18), RPS6KA1(1), RPS6KA3(5), SHC1(3), SOS1(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	10259319	102	47	100	23	38	39	16	0	9	0	0.0247	1.000	1.000
231	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(2), BAD(1), CREB1(1), CREB3(3), CREB5(4), DUSP4(1), DUSP6(5), DUSP9(1), EEF2K(1), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K8(2), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), MOS(3), NFKB1(6), RAP1A(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), SHC1(3), SOS1(7), SOS2(11), TRAF3(6)	9200215	92	43	91	23	28	32	16	2	14	0	0.145	1.000	1.000
232	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(2), APAF1(8), ATM(37), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(2), CASP6(2), CASP7(1), CASP9(2), PRKCA(4), PTK2(5), STAT1(6), TLN1(7)	8593594	81	44	80	19	19	33	14	0	13	2	0.243	1.000	1.000
233	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), CHST1(7), CHST2(1), CHST4(7), FUT8(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2)	3928973	51	32	51	15	29	6	10	1	5	0	0.283	1.000	1.000
234	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(1), CR1(10), CR2(11), HLA-DRA(5), HLA-DRB1(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	4490941	61	28	61	16	15	26	10	0	8	2	0.236	1.000	1.000
235	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5)	4460177	44	24	43	13	9	21	9	0	5	0	0.426	1.000	1.000
236	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	21	ARHGAP5(9), DIAPH1(1), FYN(5), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PIK3R1(10), PTK2(5), RAF1(6), ROCK1(15), SHC1(3), SRC(3), TLN1(7)	11220768	97	53	93	24	29	29	20	0	17	2	0.201	1.000	1.000
237	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(6), MAP3K14(3), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TNFSF13B(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	4554254	53	29	52	15	21	12	9	3	8	0	0.404	1.000	1.000
238	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), DAG1(5), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFAT5(5), PDE6A(7), PDE6B(5), PDE6C(10), PDE6D(1), SLC6A13(6), TF(11)	10939754	111	44	111	27	44	34	21	0	11	1	0.0320	1.000	1.000
239	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MAPK8(7), PLCG1(4), PTPN6(4), RAF1(6), SHC1(3), SOS1(7), STAT5B(3)	6883507	58	27	56	13	20	18	12	1	5	2	0.149	1.000	1.000
240	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(11), CAPN2(6), CAPNS1(1), CAPNS2(1), EP300(15), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(2), NFATC2(5), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SYT1(1)	7713319	63	35	63	17	27	13	11	1	11	0	0.162	1.000	1.000
241	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(37), BRCA1(6), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(7), MDM2(4), MRE11A(8), NFKB1(6), RAD50(11), RBBP8(2), RELA(2)	9420350	90	35	89	14	20	36	19	1	12	2	0.0194	1.000	1.000
242	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	20	BAD(1), BAX(1), BCL2(1), CASP8(11), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFKB1(6), NSMAF(3), RAF1(6), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	6361736	66	35	64	17	26	17	13	2	8	0	0.154	1.000	1.000
243	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(8), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(8), IL3(3), KIT(8), KITLG(2), PIK3R1(10), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), YWHAH(1)	5985213	68	41	66	23	29	18	10	0	9	2	0.316	1.000	1.000
244	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3417256	40	21	40	14	9	16	7	0	8	0	0.505	1.000	1.000
245	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(3), JAK1(4), JAK2(9), PTPRU(12), REG1A(5), STAT1(6)	3642429	40	24	38	11	20	8	7	0	3	2	0.318	1.000	1.000
246	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(2), CD3D(1), CD3G(2), IFNG(1), IL2(4), IL2RA(2), IL4(3), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), TOB1(2), TOB2(1)	3439681	52	25	51	15	19	17	7	0	9	0	0.316	1.000	1.000
247	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(11), ABCC2(14), ABCG2(9), BCHE(9), CES1(5), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6)	7388035	72	30	72	21	26	19	18	1	8	0	0.227	1.000	1.000
248	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(12), ESR2(2), PDE1A(4), PDE1B(3), PLCB1(8), PLCB2(3), PRL(3), TRH(2)	3601941	37	22	37	11	14	11	6	2	4	0	0.379	1.000	1.000
249	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	21	CSNK2A1(4), FOS(1), GRB2(3), JAK2(9), MAP2K1(4), MAPK3(3), MPL(2), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), STAT1(6), STAT3(2), STAT5B(3), THPO(2)	8955840	82	37	79	19	23	26	17	0	12	4	0.182	1.000	1.000
250	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDFT1(3), HMGCR(3), IDI1(1), LSS(2), MVK(1), NQO1(1), NQO2(1), PMVK(1), SC5DL(3), SQLE(2)	3529809	20	16	20	8	10	5	4	0	1	0	0.631	1.000	1.000
251	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(3), GUSB(2), RPE(2), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3)	5404634	39	22	39	11	15	14	3	0	7	0	0.338	1.000	1.000
252	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(8), CFTR(12), GNAS(6), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(3)	4042295	42	30	42	13	15	13	9	0	5	0	0.368	1.000	1.000
253	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(2), ITGAL(8), ITGAM(8), ITGB2(5), PECAM1(2), SELE(4), SELL(3)	3090840	35	21	35	10	10	16	5	0	4	0	0.324	1.000	1.000
254	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), GTF2F2(1), GTF2H1(4), GTF2H3(4), GTF2H4(1), GTF2IRD1(9), TAF1(12), TAF1L(22), TAF2(8), TAF4(5), TAF4B(6), TAF5(4), TAF5L(2), TAF6(3), TAF6L(2), TAF7(2), TAF7L(4), TAF9(1), TAF9B(1), TBPL1(1), TBPL2(1)	11497924	106	50	106	24	37	31	25	0	13	0	0.120	1.000	1.000
255	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG5(3), ALG6(3), ALG8(6), ALG9(2), B4GALT1(6), B4GALT2(3), B4GALT3(7), DAD1(2), DDOST(2), DHDDS(1), DPAGT1(2), DPM1(1), FUT8(2), GANAB(4), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(6)	13358103	112	52	110	28	37	36	30	0	9	0	0.0908	1.000	1.000
256	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7212813	93	44	93	25	33	28	18	0	12	2	0.137	1.000	1.000
257	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(8), CD3D(1), CD3G(2), CD4(2), CREBBP(25), CSK(3), GNAS(6), GNB1(1), GNGT1(1), HLA-DRA(5), HLA-DRB1(2), LCK(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTPRC(17), ZAP70(4)	7212813	93	44	93	25	33	28	18	0	12	2	0.137	1.000	1.000
258	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	18	ADCY1(8), ARHGEF1(5), F2(3), GNA12(2), GNA13(2), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP3K7(4), PIK3R1(10), PLCB1(8), PPP1R12B(9), PRKCA(4), PTK2B(1), ROCK1(15)	7650451	81	42	79	24	24	19	17	2	17	2	0.402	1.000	1.000
259	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	32	AKT1(2), AKT2(6), AKT3(1), BAD(1), BTK(7), CDKN2A(1), DAPP1(2), GRB2(3), GSK3A(2), GSK3B(8), IARS(6), IGFBP1(2), INPP5D(4), PDK1(2), PPP1R13B(6), PTEN(10), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SOS1(7), SOS2(11), TEC(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	10666285	113	43	109	28	34	36	25	0	17	1	0.141	1.000	1.000
260	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), B4GALNT1(4), GLB1(3), HEXB(3), LCT(20), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6)	5239738	59	31	58	20	27	16	11	0	5	0	0.402	1.000	1.000
261	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(3), CD28(2), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(8), ITGB2(5), PTPRC(17)	3612830	42	22	42	16	9	18	7	0	8	0	0.617	1.000	1.000
262	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(26), MAP2(25), PPP2CA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3), PRKCE(6)	5769231	66	37	64	20	18	23	13	0	12	0	0.569	1.000	1.000
263	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(8), CAP1(1), CCNB1(2), CDC25C(4), GNAI1(4), GNAS(6), GNB1(1), GNGT1(1), MAPK1(2), MAPK3(3), MYT1(13), PIN1(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3)	6401294	67	46	66	21	26	27	10	0	4	0	0.277	1.000	1.000
264	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	16	AKT1(2), CREB1(1), GRB2(3), MAPK1(2), MAPK3(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NTRK1(6), PIK3R1(10), PLCG1(4), RPS6KA1(1), SHC1(3)	5216200	52	30	50	15	17	9	15	0	9	2	0.410	1.000	1.000
265	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	11	DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	5157778	57	27	56	17	24	14	13	1	5	0	0.442	1.000	1.000
266	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(4), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADHA(3), PLOD1(4), PLOD2(5), PLOD3(4), SDS(2), SHMT1(2), SHMT2(2), TMLHE(3)	11844038	99	40	97	25	36	28	18	2	15	0	0.0606	1.000	1.000
267	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	12	AXIN1(2), CREBBP(25), EP300(15), FZD1(1), GSK3B(8), HDAC1(2), LDB1(5), LEF1(4), PITX2(2), TRRAP(21), WNT1(1)	8044772	86	46	85	25	37	17	18	1	13	0	0.143	1.000	1.000
268	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(9), JAK3(8), PIAS1(4), PIAS3(4), PTPRU(12), REG1A(5), SOAT1(1)	4297267	47	31	45	13	23	11	4	0	7	2	0.299	1.000	1.000
269	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(4), FOS(1), GRB2(3), JAK1(4), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), PDGFA(1), PDGFRA(17), PIK3R1(10), PLCG1(4), PRKCA(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SRF(3), STAT1(6), STAT3(2)	10183328	106	43	102	26	31	32	25	1	14	3	0.155	1.000	1.000
270	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(2), HLA-DRA(5), HLA-DRB1(2), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), IL2(4), IL2RA(2), IL4(3), IL4R(1)	4010350	46	24	46	15	15	20	6	0	3	2	0.419	1.000	1.000
271	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(3), F3(2), F5(21), F7(3), FGA(13), FGB(2), FGG(4), PROC(1), PROS1(6), SERPINC1(3), TFPI(3)	5297107	62	29	62	17	14	30	12	0	6	0	0.328	1.000	1.000
272	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	22	CXCL12(1), CXCR4(4), GNAI1(4), GNAQ(4), GNB1(1), GNGT1(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PIK3C2G(9), PIK3R1(10), PLCG1(4), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), RELA(2)	8008703	71	40	69	19	28	15	12	0	14	2	0.173	1.000	1.000
273	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(1), COASY(1), DPYD(14), DPYS(7), ENPP1(4), ENPP3(4), ILVBL(2), PANK1(2), PANK3(3), PANK4(1), PPCS(2), UPB1(5), VNN1(6)	5551019	53	29	52	19	13	24	11	0	5	0	0.626	1.000	1.000
274	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	10	ADAM17(7), AXIN1(2), BTRC(5), DLL1(4), FZD1(1), GSK3B(8), PSEN1(3), WNT1(1)	4167711	31	19	31	10	13	4	6	0	8	0	0.286	1.000	1.000
275	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(3), CD33(2), CD5(4), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(6), TLR2(6), TLR4(10), TLR7(7), TLR9(7)	5827970	69	28	68	22	25	22	19	0	3	0	0.315	1.000	1.000
276	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12)	5376728	48	24	45	14	17	19	6	0	6	0	0.327	1.000	1.000
277	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(8), CYB5R3(1), GCK(2), GFPT1(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), PGM3(5), RENBP(1)	5530338	41	25	40	13	13	19	8	0	1	0	0.514	1.000	1.000
278	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(2), ACOX1(3), ACOX3(7), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(4), FASN(1), HADHA(3), HSD17B12(2), SCD(2)	4698912	29	23	29	10	13	7	4	1	4	0	0.431	1.000	1.000
279	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(5), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), GAMT(1), GATM(1), GLUD1(2), NAGS(1), OAT(1), ODC1(5), OTC(5), SMS(2)	5566045	58	26	58	18	19	20	9	0	10	0	0.481	1.000	1.000
280	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(6), CARS(6), CARS2(1), DARS(4), DARS2(3), EPRS(11), FARS2(5), FARSA(1), FARSB(8), GARS(3), HARS(2), HARS2(4), IARS(6), IARS2(6), KARS(3), LARS(5), LARS2(3), MARS(6), MARS2(1), MTFMT(2), NARS(3), NARS2(6), QARS(8), RARS(4), RARS2(5), SARS(2), SARS2(2), TARS(6), TARS2(5), VARS(1), VARS2(6), WARS(2), WARS2(3), YARS(2), YARS2(4)	17518336	150	54	149	29	52	43	34	2	19	0	0.0124	1.000	1.000
281	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(11), C5(13), C6(13), C7(5), ICAM1(2), IL1A(1), IL6(2), IL8(1), ITGA4(8), ITGAL(8), ITGB1(6), ITGB2(5), SELP(6), SELPLG(2), VCAM1(9)	7813954	92	42	90	29	32	30	18	0	11	1	0.278	1.000	1.000
282	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(8), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), GNAS(6), GRB2(3), MAPK1(2), MAPK14(3), MAPK3(3), PIK3R1(10), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RPS6KA1(1), RPS6KA5(6), SOS1(7)	8576211	77	44	75	23	27	23	18	0	7	2	0.347	1.000	1.000
283	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	5239177	50	28	50	15	20	12	14	0	4	0	0.353	1.000	1.000
284	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(4), GNB1(1), GNGT1(1), ITGA1(3), ITGB1(6), MAP2K1(4), MAPK1(2), MAPK3(3), PLA2G4A(8), PLCB1(8), PRKCA(4), PTGS1(6), PTK2(5), RAF1(6), SRC(3), SYK(3), TBXAS1(5)	7985573	75	40	73	22	29	21	17	1	7	0	0.290	1.000	1.000
285	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(3), B3GALNT1(4), B3GALT5(4), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3)	3395659	34	20	33	12	14	8	7	0	5	0	0.522	1.000	1.000
286	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1)	5676908	54	33	53	18	19	21	8	0	6	0	0.424	1.000	1.000
287	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(5), FOS(1), MAP2K1(4), MAPK1(2), MAPK3(3), NFKB1(6), PLCB1(8), PRKCA(4), RAF1(6), RELA(2)	4959698	41	24	40	14	18	9	8	1	5	0	0.415	1.000	1.000
288	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(8), ARHGDIB(3), BIRC2(4), BIRC3(7), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), GZMB(2), LMNB1(4), LMNB2(1)	6244393	63	32	61	15	13	25	13	0	12	0	0.328	1.000	1.000
289	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(5), ALDOC(3), DERA(2), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKL(1), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(5), TKTL2(7)	7659804	67	38	67	21	27	29	8	0	3	0	0.197	1.000	1.000
290	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), G6PD(3), GPI(2), H6PD(4), PFKM(4), PFKP(2), PGD(1), PGM1(4), PGM3(5), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3)	6406420	52	34	52	17	21	25	5	0	1	0	0.267	1.000	1.000
291	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(2), AKT2(6), AKT3(1), BPNT1(1), GRB2(3), MAPK1(2), MAPK3(3), PDK1(2), PIK3CD(3), PTEN(10), PTK2B(1), RBL2(8), SHC1(3), SOS1(7)	5835347	52	28	49	15	14	15	11	0	11	1	0.508	1.000	1.000
292	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(4), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2E1(3), UBE2G1(2), UBE2I(2), UBE2J2(1), UBE2L3(2), UBE3A(11)	3346908	33	15	33	10	9	11	8	0	5	0	0.462	1.000	1.000
293	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	23	AKT1(2), AXIN1(2), CD14(1), FZD1(1), GJA1(7), GNAI1(4), GSK3B(8), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(2), NFKB1(6), PDPK1(1), PIK3R1(10), PPP2CA(1), RELA(2), TIRAP(1), TLR4(10), TOLLIP(1), WNT1(1)	6393252	68	38	67	22	29	11	15	0	11	2	0.389	1.000	1.000
294	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(6), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(6), CPT2(2), EHHADH(2), HADHA(3), SCP2(3), SLC25A20(2)	5483897	40	22	39	14	11	14	8	0	7	0	0.612	1.000	1.000
295	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(3), AP2M1(4), BAD(1), BTK(7), EEA1(9), GRASP(1), GSK3A(2), GSK3B(8), LYN(4), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PLCG1(4), PRKCE(6), RPS6KB1(3), VAV2(4)	7932797	66	36	66	19	23	20	12	0	10	1	0.275	1.000	1.000
296	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(6), IFNG(1), IKBKB(4), IL2(4), IL4(3), MAP3K1(8), MAP3K5(6), MAP4K5(2), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), TNFRSF9(3), TRAF2(1)	6224187	57	23	57	15	21	23	10	1	2	0	0.240	1.000	1.000
297	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	DUSP1(2), GORASP1(4), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK5(1), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CD(3), PIK3R1(10), SYT1(1), TRAF2(1), TRAF3(6), TRAF5(6), TRAF6(4)	9690386	86	47	85	26	24	17	19	4	20	2	0.429	1.000	1.000
298	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(9), AP2A1(3), AP2M1(4), BIN1(2), DNM1(11), EPN1(2), EPS15(7), PICALM(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYNJ1(11), SYNJ2(6), SYT1(1)	7086649	70	30	67	25	22	22	10	0	16	0	0.610	1.000	1.000
299	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	CHIA(5), CHIT1(5), CMAS(8), CTBS(4), CYB5R1(3), CYB5R3(1), GFPT1(4), GFPT2(4), GNE(2), GNPDA2(1), HEXB(3), HK1(6), HK2(3), HK3(5), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), NAGK(2), NANS(1), NPL(3), PGM3(5), PHPT1(1), RENBP(1)	9317870	80	41	79	24	32	27	14	1	6	0	0.362	1.000	1.000
300	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(2), AKT2(6), AKT3(1), CDKN1A(1), GRB2(3), MAP2K1(4), MAP2K2(1), NGFR(3), NTRK1(6), PIK3CD(3), SHC1(3), SOS1(7)	4502413	40	26	39	13	11	14	11	0	4	0	0.559	1.000	1.000
301	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(3), CDK2(2), DIAPH2(12), GMNN(1), MCM10(8), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), RFC1(14), RFC4(3), RFC5(3), RPA1(2), RPA2(1), RPA4(3), UBA52(2), UBB(2)	16056399	121	47	118	29	29	55	20	1	16	0	0.0891	1.000	1.000
302	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(1), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(5), CNDP1(3), DDC(1), HAL(4), HARS(2), HDC(8), HNMT(4), MAOA(3), MAOB(1), PRPS1(1), PRPS2(2)	7735844	80	40	80	27	31	30	16	0	3	0	0.376	1.000	1.000
303	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(11), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GPHN(12), NSF(1), SRC(3), UBQLN1(2)	3814629	69	38	65	21	19	31	11	0	8	0	0.344	1.000	1.000
304	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(4), FOS(1), GRB2(3), IL2(4), IL2RA(2), IL2RB(2), JAK1(4), JAK3(8), LCK(3), MAP2K1(4), MAPK3(3), MAPK8(7), RAF1(6), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	7472283	67	33	64	19	19	27	12	1	8	0	0.319	1.000	1.000
305	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5)	5534213	67	31	67	20	21	23	12	0	10	1	0.374	1.000	1.000
306	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(3), IL4(3), IL4R(1), IRS1(8), JAK1(4), JAK3(8), RPS6KB1(3), SHC1(3), STAT6(2)	4691469	37	24	35	12	11	14	5	0	7	0	0.529	1.000	1.000
307	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY7(4), ADCY8(12), ADCY9(6), ADORA2A(5), ADORA2B(1), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), AGTR1(5), ATP2A1(6), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), ATP2B4(8), AVPR1A(4), AVPR1B(3), BDKRB2(3), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CCKAR(2), CCKBR(5), CD38(2), CHRM1(3), CHRM2(11), CHRM3(4), CHRM5(2), CHRNA7(1), CYSLTR1(3), CYSLTR2(4), DRD1(1), EDNRA(4), EDNRB(12), EGFR(11), ERBB2(10), ERBB3(14), ERBB4(21), GNA11(1), GNA14(6), GNA15(3), GNAL(4), GNAQ(4), GNAS(6), GRIN1(1), GRIN2A(21), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), GRPR(3), HRH1(1), HRH2(4), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), LHCGR(4), MYLK(14), MYLK2(3), NOS1(11), NOS3(2), NTSR1(1), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), PDE1A(4), PDE1B(3), PDE1C(9), PDGFRA(17), PDGFRB(6), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PLN(1), PPID(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTAFR(1), PTGER3(7), PTGFR(7), PTK2B(1), RYR1(25), RYR2(59), RYR3(42), SLC25A4(1), SLC25A5(1), SLC8A1(13), SLC8A2(4), SLC8A3(7), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(7), TNNC2(1), TRHR(8), TRPC1(6), VDAC1(1), VDAC3(1)	81687023	956	171	939	373	393	298	174	8	79	4	0.513	1.000	1.000
308	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	189	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), ARHGAP5(9), BAD(1), BCL2(1), BIRC2(4), BIRC3(7), CAPN2(6), CAV1(1), CAV2(1), CAV3(3), CCND2(1), CCND3(1), CDC42(1), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), COMP(2), CRKL(2), DIAPH1(1), DOCK1(7), EGF(3), EGFR(11), ERBB2(10), FARP2(5), FIGF(2), FLNA(3), FLNB(16), FLNC(13), FLT1(12), FN1(21), FYN(5), GRB2(3), GRLF1(12), GSK3B(8), HGF(8), IBSP(3), IGF1(2), IGF1R(8), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), KDR(10), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), MAP2K1(4), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), MET(5), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PRKCA(4), PRKCG(10), PTEN(10), PTK2(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF1(6), RELN(33), RHOA(5), ROCK1(15), ROCK2(6), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SPP1(1), SRC(3), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TLN1(7), TLN2(8), TNC(16), TNN(17), TNR(21), TNXB(17), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCL(2), VEGFA(2), VEGFB(2), VEGFC(6), VTN(6), VWF(15), ZYX(1)	115206291	1206	170	1185	444	438	398	212	11	142	5	0.544	1.000	1.000
309	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	234	ADCYAP1R1(2), ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA2A(3), ADRA2B(1), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), C5AR1(3), CALCR(5), CALCRL(6), CCKAR(2), CCKBR(5), CGA(2), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CNR1(5), CRHR1(2), CRHR2(5), CTSG(3), CYSLTR1(3), CYSLTR2(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), EDNRB(12), F2(3), F2RL1(1), F2RL2(3), FPR1(2), FSHB(2), FSHR(7), GABBR1(6), GABBR2(7), GABRA1(4), GABRA2(9), GABRA3(5), GABRA4(8), GABRA5(9), GABRA6(5), GABRB1(7), GABRB2(7), GABRB3(9), GABRE(5), GABRG2(11), GABRG3(5), GABRP(4), GABRQ(8), GABRR1(2), GABRR2(4), GALR1(2), GH1(2), GH2(3), GHR(6), GHRHR(2), GHSR(5), GLP1R(7), GLP2R(5), GLRA1(2), GLRA2(3), GLRA3(8), GLRB(7), GNRHR(4), GPR156(8), GPR50(5), GPR63(4), GPR83(1), GRIA1(19), GRIA2(13), GRIA3(8), GRIA4(19), GRID1(16), GRID2(12), GRIK1(5), GRIK2(14), GRIK3(19), GRIK4(12), GRIK5(6), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRIN3A(6), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM6(10), GRM7(11), GRM8(9), GRPR(3), GZMA(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LEP(1), LEPR(9), LHB(1), LHCGR(4), LTB4R(1), MAS1(2), MC2R(5), MC3R(1), MC4R(4), MC5R(6), MCHR1(6), MCHR2(3), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPBWR1(3), NPFFR2(4), NPY1R(4), NPY2R(5), NPY5R(2), NR3C1(4), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), P2RX1(1), P2RX2(2), P2RX3(2), P2RX4(3), P2RX5(1), P2RX7(3), P2RY1(6), P2RY10(7), P2RY13(2), P2RY14(6), P2RY2(3), P2RY4(6), P2RY6(1), PARD3(7), PPYR1(4), PRL(3), PRLR(4), PRSS1(3), PRSS3(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGER3(7), PTGFR(7), PTGIR(1), PTH2R(7), RXFP1(3), RXFP2(10), SCTR(3), SSTR1(5), SSTR2(3), SSTR4(4), TAAR1(4), TAAR2(2), TAAR5(6), TAAR6(5), TAAR8(2), TAAR9(3), TACR1(2), TACR2(1), TACR3(7), THRA(2), THRB(4), TRHR(8), TRPV1(4), TSHB(1), TSHR(7), VIPR1(4), VIPR2(3)	69460093	986	169	973	370	385	323	190	10	77	1	0.193	1.000	1.000
310	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	ACTB(2), CHAD(7), COL11A1(24), COL11A2(11), COL17A1(8), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), COMP(2), DES(1), DSC1(8), DSC2(2), DSC3(4), DSG1(8), DSG2(5), DSG3(8), DSG4(9), FN1(21), GJA1(7), GJA10(9), GJA4(2), GJA5(3), GJA8(5), GJA9(4), GJB1(3), GJB3(4), GJB4(1), GJB7(2), GJC1(4), GJC2(1), GJC3(2), GJD2(1), GJD4(2), IBSP(3), INA(2), ITGA6(4), ITGB4(3), KRT1(4), KRT10(2), KRT12(2), KRT13(4), KRT14(2), KRT15(2), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT20(1), KRT23(1), KRT24(3), KRT25(3), KRT27(2), KRT28(1), KRT3(6), KRT31(4), KRT32(2), KRT33A(2), KRT33B(5), KRT34(4), KRT35(3), KRT36(2), KRT37(6), KRT38(2), KRT4(2), KRT5(4), KRT6A(4), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT72(5), KRT73(4), KRT74(4), KRT75(6), KRT76(2), KRT77(1), KRT78(4), KRT79(3), KRT8(1), KRT81(1), KRT82(6), KRT83(1), KRT84(9), KRT85(6), KRT9(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), LMNB1(4), LMNB2(1), NES(7), PRPH(2), RELN(33), SPP1(1), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNR(21), TNXB(17), VIM(3), VTN(6), VWF(15)	77873425	843	151	836	334	335	295	123	10	79	1	0.806	1.000	1.000
311	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRB1(3), ADRB3(1), ANXA6(3), ARRB1(1), ATP1A4(8), ATP1B1(1), ATP1B2(2), ATP2A2(6), ATP2A3(4), ATP2B1(9), ATP2B2(11), ATP2B3(4), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1S(14), CACNB1(1), CACNB3(2), CALR(1), CAMK1(3), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CASQ1(2), CASQ2(4), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), GJA1(7), GJA4(2), GJA5(3), GJB1(3), GJB3(4), GJB4(1), GNA11(1), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), ITPR1(19), ITPR2(18), ITPR3(12), KCNB1(5), KCNJ3(6), KCNJ5(4), MIB1(3), MYCBP(1), NME7(5), PEA15(1), PKIA(1), PKIB(1), PLCB3(4), PLN(1), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKD1(15), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SLC8A3(7), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	56536224	656	142	652	268	282	211	105	1	55	2	0.762	1.000	1.000
312	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(7), COL11A1(24), COL11A2(11), COL1A1(11), COL1A2(16), COL2A1(9), COL3A1(12), COL4A1(14), COL4A2(4), COL4A4(10), COL4A6(15), COL5A1(15), COL5A2(13), COL5A3(10), COL6A2(1), COL6A3(43), COL6A6(20), DAG1(5), FN1(21), FNDC1(23), FNDC3A(7), FNDC4(1), GP5(6), GP6(2), HMMR(6), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAV(5), ITGB1(6), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LAMA1(24), LAMA2(25), LAMA3(18), LAMA4(11), LAMB1(8), LAMB2(5), LAMB3(9), LAMB4(16), LAMC1(11), LAMC2(10), LAMC3(8), RELN(33), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SPP1(1), SV2A(5), SV2B(6), SV2C(4), THBS1(10), THBS2(15), THBS3(3), THBS4(2), TNC(16), TNN(17), TNR(21), TNXB(17), VTN(6), VWF(15)	71167075	761	142	753	305	277	267	125	9	82	1	0.869	1.000	1.000
313	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(1), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), APC2(1), ARAF(3), ARHGEF1(5), ARHGEF12(9), ARHGEF4(4), ARHGEF6(10), ARHGEF7(7), ARPC1A(5), ARPC1B(2), ARPC2(2), ARPC5(1), ARPC5L(2), BAIAP2(1), BDKRB2(3), CD14(1), CDC42(1), CFL1(1), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CRKL(2), CSK(3), CYFIP1(6), CYFIP2(5), DIAPH1(1), DIAPH2(12), DIAPH3(5), DOCK1(7), EGF(3), EGFR(11), EZR(2), F2(3), FGD1(8), FGD3(2), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FN1(21), GIT1(3), GNA12(2), GNA13(2), GRLF1(12), IQGAP1(13), IQGAP2(12), IQGAP3(11), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), LIMK1(5), LIMK2(5), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MOS(3), MRAS(1), MSN(6), MYH10(10), MYH14(12), MYH9(12), MYL2(1), MYL7(1), MYL9(2), MYLK(14), MYLK2(3), NCKAP1(9), NCKAP1L(11), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDGFA(1), PDGFRA(17), PDGFRB(6), PFN2(1), PFN4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP1R12B(9), PTK2(5), RAF1(6), RDX(3), RHOA(5), ROCK1(15), ROCK2(6), RRAS2(2), SCIN(3), SLC9A1(4), SOS1(7), SOS2(11), SSH1(6), SSH2(4), SSH3(1), TIAM1(17), TIAM2(16), TMSL3(1), VAV1(13), VAV2(4), VAV3(12), VCL(2), WAS(1), WASF1(3), WASF2(2), WASL(7)	83822586	820	138	809	272	320	252	146	8	90	4	0.141	1.000	1.000
314	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	241	ACVR1C(3), AKT1(2), AKT2(6), AKT3(1), ARRB1(1), ATF2(1), ATF4(1), BDNF(1), CACNA1A(17), CACNA1B(11), CACNA1C(12), CACNA1D(8), CACNA1E(21), CACNA1F(14), CACNA1G(10), CACNA1H(2), CACNA1I(5), CACNA1S(14), CACNA2D1(11), CACNA2D2(1), CACNA2D3(6), CACNA2D4(3), CACNB1(1), CACNB2(6), CACNB3(2), CACNB4(2), CACNG1(2), CACNG2(3), CACNG3(8), CACNG4(2), CACNG5(5), CACNG6(1), CACNG7(6), CACNG8(1), CASP3(2), CD14(1), CDC25B(5), CDC42(1), CHUK(6), CRKL(2), DAXX(1), DUSP1(2), DUSP10(5), DUSP16(5), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(5), DUSP7(2), DUSP9(1), ECSIT(3), EGF(3), EGFR(11), ELK4(2), FAS(2), FASLG(1), FGF1(2), FGF11(3), FGF12(3), FGF13(3), FGF14(5), FGF17(1), FGF19(1), FGF20(2), FGF21(1), FGF23(1), FGF3(1), FGF5(4), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(4), FGFR2(6), FGFR3(2), FGFR4(2), FLNA(3), FLNB(16), FLNC(13), FOS(1), GNA12(2), GRB2(3), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(5), MAX(1), MEF2C(9), MKNK1(1), MKNK2(3), MOS(3), MRAS(1), NF1(9), NFATC2(5), NFATC4(5), NFKB1(6), NFKB2(4), NLK(1), NR4A1(2), NTF3(1), NTRK1(6), NTRK2(4), PAK1(5), PAK2(3), PDGFA(1), PDGFRA(17), PDGFRB(6), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PPM1A(7), PPM1B(2), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PPP5C(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PTPN5(1), PTPN7(2), PTPRR(5), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF2(13), RASA1(9), RASA2(3), RASGRF1(12), RASGRF2(9), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KA6(7), RRAS2(2), SOS1(7), SOS2(11), SRF(3), STK3(3), STK4(3), STMN1(2), TAOK1(5), TAOK2(3), TAOK3(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF1A(1), TRAF2(1), TRAF6(4), ZAK(6)	86898644	858	137	844	307	348	234	168	8	94	6	0.316	1.000	1.000
315	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(4), ABLIM1(6), ABLIM2(4), ABLIM3(5), ARHGEF12(9), CDC42(1), CFL1(1), CXCL12(1), CXCR4(4), DCC(16), DPYSL2(5), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(5), EFNB1(3), EFNB2(1), EFNB3(3), EPHA1(6), EPHA2(5), EPHA3(17), EPHA4(6), EPHA5(17), EPHA6(5), EPHA7(10), EPHA8(7), EPHB1(9), EPHB2(8), EPHB3(2), EPHB4(5), EPHB6(4), FYN(5), GNAI1(4), GSK3B(8), ITGB1(6), L1CAM(4), LIMK1(5), LIMK2(5), LRRC4C(8), MAPK1(2), MAPK3(3), MET(5), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NGEF(1), NRP1(1), NTN1(5), NTN4(6), NTNG1(4), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLXNA1(2), PLXNA2(8), PLXNA3(2), PLXNB1(5), PLXNB2(2), PLXNB3(3), PLXNC1(9), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(9), RGS3(10), RHOA(5), RND1(1), ROBO1(24), ROBO2(18), ROBO3(5), ROCK1(15), ROCK2(6), SEMA3A(9), SEMA3B(1), SEMA3C(3), SEMA3D(13), SEMA3E(9), SEMA3F(1), SEMA3G(4), SEMA4A(3), SEMA4B(2), SEMA4D(13), SEMA4F(9), SEMA4G(6), SEMA5A(8), SEMA5B(11), SEMA6A(2), SEMA6B(2), SEMA6C(3), SEMA6D(9), SEMA7A(2), SLIT1(11), SLIT2(15), SLIT3(9), SRGAP1(9), SRGAP2(3), SRGAP3(4), UNC5A(2), UNC5B(6), UNC5C(12), UNC5D(9)	60626028	621	137	611	196	248	180	107	7	79	0	0.0557	1.000	1.000
316	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADM(2), ARRB1(1), ATF1(2), ATF2(1), ATF3(1), ATF4(1), ATP2A2(6), ATP2A3(4), CACNB3(2), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CNN1(1), CNN2(1), CORIN(13), CREB3(3), CRHR1(2), DGKZ(3), ETS2(3), FOS(1), GABPA(4), GABPB2(3), GBA2(5), GJA1(7), GNAQ(4), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), GRK4(5), GRK5(4), GRK6(3), GSTO1(1), GUCA2B(2), GUCY1A3(17), IGFBP1(2), IGFBP2(1), IGFBP3(4), IGFBP4(2), IL1B(1), IL6(2), ITPR1(19), ITPR2(18), ITPR3(12), MIB1(3), MYL2(1), MYL4(1), MYLK2(3), NFKB1(6), NOS1(11), NOS3(2), OXTR(3), PDE4B(5), PDE4D(4), PKIA(1), PKIB(1), PLCB3(4), PLCD1(7), PLCG1(4), PLCG2(13), PRKACA(1), PRKACB(1), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCH(3), PRKCQ(5), PRKD1(15), RAMP1(1), RAMP3(4), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(2), RGS18(2), RGS2(3), RGS20(4), RGS3(10), RGS4(3), RGS5(1), RGS6(3), RGS7(6), RGS9(7), RLN1(1), RYR1(25), RYR2(59), RYR3(42), SLC8A1(13), SP1(2), TNXB(17), USP5(4), YWHAB(2), YWHAH(1), YWHAQ(1)	52220205	598	133	591	212	244	201	92	2	58	1	0.216	1.000	1.000
317	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(8), ADORA2A(5), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), AGTR1(5), AGTR2(5), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CCRL1(5), CHML(5), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), CMKLR1(2), CNR1(5), CX3CR1(2), CXCR4(4), DRD1(1), DRD2(5), DRD3(3), DRD5(6), EDNRA(4), EDNRB(12), F2RL1(1), F2RL2(3), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(3), GPR37(7), GPR37L1(3), GPR4(1), GPR50(5), GPR6(6), GPR63(4), GPR77(2), GPR83(1), GPR85(1), GPR87(5), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7), LHCGR(4), LTB4R(1), MAS1(2), MC3R(1), MC4R(4), MC5R(6), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(9), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(3), OR12D3(4), OR1C1(3), OR1F1(2), OR2H1(5), OR5V1(3), OR7A5(3), OR7C1(6), OR8B8(3), OXTR(3), P2RY1(6), P2RY10(7), P2RY12(4), P2RY13(2), P2RY14(6), P2RY2(3), P2RY6(1), PPYR1(4), PTAFR(1), PTGDR(1), PTGER2(1), PTGFR(7), PTGIR(1), RGR(3), RHO(3), RRH(4), SSTR1(5), SSTR2(3), SSTR4(4), SUCNR1(2), TRHR(8)	37266461	473	125	471	166	188	164	85	3	33	0	0.0215	1.000	1.000
318	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	128	ALCAM(2), CADM1(8), CADM3(8), CD2(3), CD22(10), CD226(4), CD274(4), CD28(2), CD34(1), CD4(2), CD40(1), CD40LG(6), CD58(2), CD6(3), CD80(1), CD8B(2), CDH1(5), CDH15(1), CDH3(4), CDH4(11), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CNTN1(17), CNTN2(7), CNTNAP1(7), CNTNAP2(12), CTLA4(2), ESAM(3), F11R(1), GLG1(4), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(8), ITGA6(4), ITGA8(8), ITGA9(6), ITGAL(8), ITGAM(8), ITGAV(5), ITGB1(6), ITGB2(5), ITGB7(4), ITGB8(5), JAM3(3), L1CAM(4), MAG(7), MPZL1(1), NCAM1(6), NCAM2(16), NEGR1(4), NEO1(6), NFASC(17), NLGN1(7), NLGN2(2), NLGN3(4), NRCAM(7), NRXN1(24), NRXN2(6), NRXN3(18), OCLN(1), PDCD1LG2(1), PECAM1(2), PTPRC(17), PTPRF(9), PTPRM(27), PVR(1), PVRL1(6), PVRL2(4), PVRL3(2), SDC1(1), SDC2(3), SDC3(3), SDC4(1), SELE(4), SELL(3), SELP(6), SELPLG(2), SIGLEC1(4), SPN(2), VCAM1(9), VCAN(36)	46136457	546	124	535	199	182	184	102	7	67	4	0.370	1.000	1.000
319	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	244	ACVR1(4), ACVR2B(4), AMHR2(2), BMP2(1), BMP7(6), BMPR1A(4), BMPR1B(10), BMPR2(9), CCL13(1), CCL15(1), CCL18(2), CCL22(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CCR9(6), CD27(3), CD40(1), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(2), CSF1R(3), CSF2RB(7), CSF3R(10), CX3CL1(1), CX3CR1(2), CXCL10(1), CXCL11(3), CXCL12(1), CXCL14(2), CXCL16(1), CXCL5(2), CXCL6(1), CXCL9(3), CXCR4(4), EDA(2), EDA2R(2), EDAR(3), EGF(3), EGFR(11), FAS(2), FASLG(1), FLT1(12), FLT3(5), FLT3LG(1), FLT4(5), GDF5(2), GH1(2), GH2(3), GHR(6), HGF(8), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL15(1), IL15RA(1), IL17A(2), IL17RA(6), IL17RB(1), IL18R1(10), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL1RAP(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL8(1), IL9(2), INHBA(10), INHBB(1), INHBC(3), INHBE(1), KDR(10), KIT(8), KITLG(2), LEP(1), LEPR(9), LIFR(24), LTB(1), LTBR(3), MET(5), MPL(2), NGFR(3), OSM(1), OSMR(6), PDGFC(3), PDGFRA(17), PDGFRB(6), PLEKHO2(5), PRL(3), PRLR(4), RELT(2), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF11A(3), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(5), TNFRSF4(1), TNFRSF8(2), TNFRSF9(3), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF13B(1), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(11), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(6), XCL2(1), XCR1(1)	55213048	611	123	601	206	193	219	117	1	80	1	0.276	1.000	1.000
320	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADRB1(3), CSNK1D(4), DRD1(1), DRD2(5), EGF(3), EGFR(11), GJA1(7), GJD2(1), GNA11(1), GNAI1(4), GNAQ(4), GNAS(6), GRB2(3), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HTR2A(3), HTR2B(1), HTR2C(8), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAP2K5(4), MAP3K2(3), MAPK1(2), MAPK3(3), MAPK7(3), NPR1(6), NPR2(10), PDGFA(1), PDGFC(3), PDGFD(3), PDGFRA(17), PDGFRB(6), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), PRKX(2), RAF1(6), SOS1(7), SOS2(11), SRC(3), TJP1(7), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3)	40840017	482	121	478	177	194	161	79	4	41	3	0.464	1.000	1.000
321	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	137	APC2(1), AXIN1(2), AXIN2(9), BTRC(5), CACYBP(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(6), CREBBP(25), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNBIP1(1), CUL1(8), CXXC4(1), DAAM1(2), DAAM2(9), DKK1(5), DKK2(6), DVL2(9), DVL3(4), EP300(15), FBXW11(8), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LEF1(4), LRP5(5), LRP6(17), MAP3K7(4), MAPK10(8), MAPK8(7), MAPK9(5), MMP7(5), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PORCN(2), PPARD(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRICKLE1(11), PRICKLE2(6), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), PSEN1(3), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RUVBL1(8), SENP2(3), SFRP1(3), SFRP2(3), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD3(9), SOX17(2), TBL1X(6), TBL1XR1(6), TBL1Y(1), TCF7(6), TCF7L1(3), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	46690037	501	120	491	145	197	145	90	5	64	0	0.00761	1.000	1.000
322	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(3), ACTN2(8), ACTN3(3), ACTN4(3), DES(1), DMD(47), FAM48A(6), MYBPC1(7), MYBPC2(4), MYBPC3(3), MYH3(14), MYH6(12), MYH7(11), MYH8(20), MYL1(1), MYL2(1), MYL4(1), MYL9(2), MYOM1(12), NEB(54), TMOD1(3), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(6), TPM3(3), TPM4(4), TTN(290), VIM(3)	35535194	535	119	522	154	174	197	111	5	40	8	0.107	1.000	1.000
323	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	141	ADA(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), AK7(6), ALLC(5), AMPD1(8), AMPD2(5), AMPD3(3), ATIC(4), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), FHIT(1), GART(3), GMPR(2), GMPR2(2), GMPS(5), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NME6(4), NME7(5), NPR1(6), NPR2(10), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT9(2), PAICS(1), PAPSS1(2), PAPSS2(4), PDE10A(11), PDE11A(8), PDE1A(4), PDE1C(9), PDE3B(3), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6D(1), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PDE9A(6), PFAS(1), PKM2(2), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(10), POLR3GL(1), POLR3H(1), POLR3K(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RFC5(3), RRM1(2), RRM2(2), XDH(7)	52329066	509	115	501	166	166	181	88	3	71	0	0.219	1.000	1.000
324	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	127	ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), AKT1(2), AKT2(6), AKT3(1), AMOTL1(13), ASH1L(24), CASK(4), CDC42(1), CDK4(3), CGN(7), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTTN(1), EPB41(3), EPB41L1(9), EPB41L2(6), EPB41L3(18), EXOC4(7), F11R(1), GNAI1(4), HCLS1(8), IGSF5(8), INADL(5), JAM3(3), LLGL1(1), LLGL2(2), MAGI1(13), MAGI2(11), MAGI3(6), MLLT4(6), MPDZ(11), MPP5(3), MRAS(1), MYH1(15), MYH10(10), MYH11(28), MYH13(15), MYH14(12), MYH15(12), MYH2(12), MYH3(14), MYH4(12), MYH6(12), MYH7(11), MYH7B(6), MYH8(20), MYH9(12), MYL2(1), MYL7(1), MYL9(2), OCLN(1), PARD3(7), PARD6A(2), PARD6G(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PPP2R3A(5), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PTEN(10), RAB3B(1), RHOA(5), RRAS2(2), SPTAN1(13), SRC(3), SYMPK(5), TJAP1(1), TJP1(7), TJP2(5), TJP3(1), YES1(1), ZAK(6)	59503992	606	109	592	199	258	182	92	3	67	4	0.192	1.000	1.000
325	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(4), ABL2(7), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CBL(5), CBLB(8), CDKN1A(1), CDKN1B(3), CRKL(2), EGF(3), EGFR(11), ERBB2(10), ERBB3(14), ERBB4(21), EREG(1), GAB1(6), GRB2(3), GSK3B(8), HBEGF(1), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), NCK1(1), NRG1(15), NRG2(6), NRG3(7), NRG4(1), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), RAF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SRC(3), STAT5B(3)	31537146	328	108	315	95	107	98	68	5	48	2	0.107	1.000	1.000
326	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	145	AKT1(2), AKT2(6), AKT3(1), BCL2L1(1), CBL(5), CBLB(8), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(25), CSF2RB(7), CSF3R(10), EP300(15), GH1(2), GH2(3), GHR(6), GRB2(3), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), IFNK(1), IL10(2), IL10RA(2), IL10RB(5), IL11(1), IL11RA(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL13(1), IL13RA1(2), IL13RA2(3), IL15(1), IL15RA(1), IL19(1), IL2(4), IL20(3), IL20RA(5), IL21(2), IL21R(5), IL22(2), IL22RA1(1), IL23R(3), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL6ST(3), IL7(2), IL7R(3), IL9(2), IRF9(3), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), LIFR(24), MPL(2), OSM(1), OSMR(6), PIAS1(4), PIAS2(3), PIAS3(4), PIAS4(1), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIM1(1), PRL(3), PRLR(4), PTPN11(5), PTPN6(4), SOCS2(3), SOCS4(1), SOCS5(4), SOS1(7), SOS2(11), SPRED1(7), SPRED2(6), SPRY1(3), SPRY4(2), STAM(2), STAM2(2), STAT1(6), STAT2(7), STAT3(2), STAT4(3), STAT5B(3), STAT6(2), TPO(11), TSLP(2), TYK2(1)	44667616	448	108	439	134	149	155	85	2	53	4	0.109	1.000	1.000
327	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	71	ARAF(3), C7orf16(4), CACNA1A(17), CRHR1(2), GNA11(1), GNA12(2), GNA13(2), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GNAZ(1), GRIA1(19), GRIA2(13), GRIA3(8), GRID2(12), GRM1(12), GRM5(11), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), IGF1(2), IGF1R(8), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), NOS1(11), NOS3(2), NPR1(6), NPR2(10), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), PRKCA(4), PRKCG(10), PRKG1(9), PRKG2(5), RAF1(6), RYR1(25)	33756680	408	108	399	156	167	133	72	2	33	1	0.711	1.000	1.000
328	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	107	ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ARHGAP5(9), CDC42(1), CDH5(2), CLDN10(4), CLDN11(1), CLDN15(1), CLDN16(5), CLDN17(5), CLDN18(2), CLDN19(1), CLDN2(1), CLDN6(2), CLDN7(2), CLDN8(5), CLDN9(1), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), CXCL12(1), CXCR4(4), CYBB(2), ESAM(3), EZR(2), F11R(1), GNAI1(4), GRLF1(12), ICAM1(2), ITGA4(8), ITGAL(8), ITGAM(8), ITGB1(6), ITGB2(5), ITK(11), JAM3(3), MAPK12(2), MAPK13(1), MAPK14(3), MLLT4(6), MMP2(5), MMP9(11), MSN(6), MYL2(1), MYL7(1), MYL9(2), NCF1(1), NCF2(2), NCF4(3), NOX1(1), NOX3(8), OCLN(1), PECAM1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PRKCA(4), PRKCG(10), PTK2(5), PTK2B(1), PTPN11(5), RAP1A(2), RAP1B(2), RAPGEF3(4), RAPGEF4(7), RASSF5(3), RHOA(5), RHOH(2), ROCK1(15), ROCK2(6), SIPA1(1), TXK(5), VASP(3), VAV1(13), VAV2(4), VAV3(12), VCAM1(9), VCL(2)	37432244	408	106	400	120	166	118	71	1	50	2	0.0257	1.000	1.000
329	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	92	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), ATF4(1), CACNA1C(12), CACNA1D(8), CACNA1F(14), CACNA1S(14), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CDC42(1), CGA(2), EGFR(11), FSHB(2), GNA11(1), GNAQ(4), GNAS(6), GNRHR(4), GRB2(3), HBEGF(1), ITPR1(19), ITPR2(18), ITPR3(12), LHB(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK7(3), MAPK8(7), MAPK9(5), MMP14(4), MMP2(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLD1(11), PLD2(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCD(3), PRKX(2), PTK2B(1), RAF1(6), SOS1(7), SOS2(11), SRC(3)	39689701	393	104	389	139	151	120	75	5	41	1	0.374	1.000	1.000
330	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	95	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CREB1(1), CREB3(3), CREB3L1(3), CREB3L2(4), CREB3L3(3), CREB3L4(1), CREBBP(25), DCT(13), DVL2(9), DVL3(4), EDN1(1), EDNRB(12), EP300(15), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD4(2), FZD6(6), FZD7(3), FZD8(1), GNAI1(4), GNAO1(5), GNAQ(4), GNAS(6), GSK3B(8), KIT(8), KITLG(2), LEF1(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MITF(5), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), POMC(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), TCF7(6), TCF7L1(3), TYR(3), TYRP1(2), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2)	33204092	362	103	357	139	148	107	63	6	38	0	0.516	1.000	1.000
331	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	127	ACACA(18), ACACB(15), AKT1(2), AKT2(6), AKT3(1), ARAF(3), BAD(1), CBL(5), CBLB(8), CRKL(2), EXOC7(2), FASN(1), FBP2(3), FLOT1(3), FOXO1(1), G6PC(4), G6PC2(1), GCK(2), GRB2(3), GSK3B(8), GYS1(2), GYS2(11), IKBKB(4), INPP5D(4), INSR(6), IRS1(8), IRS4(15), LIPE(4), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK9(5), MKNK1(1), MKNK2(3), PCK1(3), PCK2(3), PDE3A(5), PDE3B(3), PDPK1(1), PFKL(1), PFKM(4), PFKP(2), PHKA1(8), PHKA2(6), PHKB(6), PHKG2(3), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(2), PPP1CC(2), PPP1R3A(13), PPP1R3B(1), PPP1R3C(4), PPP1R3D(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCI(4), PRKX(2), PTPN1(5), PTPRF(9), PYGB(4), PYGL(2), PYGM(4), RAF1(6), RAPGEF1(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SLC2A4(4), SOCS2(3), SOCS4(1), SORBS1(11), SOS1(7), SOS2(11), SREBF1(1), TSC1(4), TSC2(2)	49781511	427	102	417	155	152	134	82	5	52	2	0.564	1.000	1.000
332	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADCY9(6), AKAP10(3), AKAP11(7), AKAP12(14), AKAP3(10), AKAP4(4), AKAP5(3), AKAP6(16), AKAP7(3), AKAP8(3), AKAP9(26), ARHGEF1(5), GNA11(1), GNA12(2), GNA13(2), GNA14(6), GNA15(3), GNAL(4), GNAO1(5), GNAQ(4), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG4(1), GNG7(1), GNGT1(1), IL18BP(2), ITPR1(19), KCNJ3(6), PDE1A(4), PDE1B(3), PDE1C(9), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE7A(3), PDE7B(4), PDE8A(1), PDE8B(7), PLCB3(4), PPP3CA(3), PPP3CC(4), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD1(15), PRKD3(8), RHOA(5), SLC9A1(4), USP5(4)	36592592	369	100	363	135	134	123	60	2	48	2	0.536	1.000	1.000
333	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(1), CAPN1(2), CAPN10(3), CAPN11(2), CAPN2(6), CAPN3(6), CAPN5(5), CAPN6(3), CAPN7(4), CAPN9(1), CAPNS1(1), CAV1(1), CAV2(1), CAV3(3), CDC42(1), CSK(3), DOCK1(7), FYN(5), GIT2(7), GRB2(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGAD(8), ITGAE(7), ITGAL(8), ITGAM(8), ITGAV(5), ITGAX(6), ITGB1(6), ITGB2(5), ITGB3(9), ITGB4(3), ITGB5(6), ITGB6(6), ITGB7(4), ITGB8(5), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAPK10(8), MAPK12(2), MAPK4(1), MAPK6(3), MAPK7(3), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(6), RHO(3), ROCK1(15), ROCK2(6), SEPP1(1), SHC1(3), SHC3(1), SORBS1(11), SOS1(7), SRC(3), TLN1(7), TNS1(14), VASP(3), VAV2(4), VAV3(12), VCL(2), ZYX(1)	42034791	373	98	365	137	126	128	66	9	44	0	0.626	1.000	1.000
334	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(4), ALG1(1), ALG10(3), ALG10B(7), ALG11(1), ALG12(2), ALG13(1), ALG14(1), ALG2(3), ALG3(1), ALG6(3), ALG8(6), ALG9(2), B3GNT1(2), B3GNT2(2), B3GNT7(6), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(7), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHST2(1), CHST4(7), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(2), EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), FUT11(1), FUT8(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GANAB(4), GCNT1(5), GCNT3(4), GCNT4(7), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(5), MAN1A2(2), MAN1B1(2), MAN1C1(7), MAN2A1(12), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4), OGT(5), RPN2(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(3), STT3B(6), UST(1), XYLT1(6), XYLT2(2)	34485883	349	97	345	108	129	107	75	3	35	0	0.168	1.000	1.000
335	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	64	ADCY1(8), ADCY8(12), ARAF(3), ATF4(1), CACNA1C(12), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CREBBP(25), EP300(15), GNAQ(4), GRIA1(19), GRIA2(13), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), GRM1(12), GRM5(11), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PPP1CB(2), PPP1CC(2), PPP1R12A(3), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKCA(4), PRKCG(10), PRKX(2), RAF1(6), RAP1A(2), RAP1B(2), RAPGEF3(4), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7)	30477342	350	97	347	131	146	92	73	3	34	2	0.557	1.000	1.000
336	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(3), ADCY1(8), ADCY2(15), ADCY3(2), ADCY4(9), ADCY5(11), ADCY6(1), ADCY7(4), ADCY8(12), ADK(1), ADSL(7), ADSS(2), AK2(1), AK5(5), ALLC(5), AMPD1(8), AMPD2(5), AMPD3(3), ATIC(4), ATP1B1(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(2), ENPP1(4), ENPP3(4), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(12), GUCY1A3(17), GUCY1B3(9), GUCY2C(8), GUCY2D(8), GUCY2F(11), HPRT1(2), IMPDH1(2), IMPDH2(4), ITPA(2), NPR1(6), NPR2(10), NT5E(3), NT5M(1), PAICS(1), PAPSS1(2), PAPSS2(4), PDE1A(4), PDE4A(4), PDE4B(5), PDE4C(2), PDE4D(4), PDE5A(6), PDE6B(5), PDE6C(10), PDE7B(4), PDE8A(1), PDE9A(6), PFAS(1), PKM2(2), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), PPAT(6), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(1), RRM1(2), RRM2(2)	40989844	392	97	385	118	131	136	69	3	53	0	0.112	1.000	1.000
337	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVR1(4), ACVRL1(4), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(9), BUB1(6), CDKL1(4), CDKL2(4), CDS1(2), CDS2(4), CLK1(6), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MAP3K10(3), MOS(3), NEK1(9), NEK3(4), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13), PLK3(2), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), PRKD1(15), PRKG1(9), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), TGFBR1(9), VRK1(4)	34858761	353	96	347	103	140	109	69	2	33	0	0.0757	1.000	1.000
338	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	70	ACP1(2), ACTB(2), ACTN1(5), ACTN2(8), ACTN3(3), ACTN4(3), ACVR1C(3), BAIAP2(1), CDC42(1), CDH1(5), CREBBP(25), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(12), CTNNA2(12), CTNNA3(9), CTNND1(6), EGFR(11), EP300(15), ERBB2(10), FARP2(5), FER(6), FGFR1(4), FYN(5), IGF1R(8), INSR(6), IQGAP1(13), LEF1(4), LMO7(19), MAP3K7(4), MAPK1(2), MAPK3(3), MET(5), MLLT4(6), NLK(1), PARD3(7), PTPN1(5), PTPN6(4), PTPRB(4), PTPRF(9), PTPRJ(4), PTPRM(27), PVRL1(6), PVRL2(4), PVRL3(2), PVRL4(4), RHOA(5), SMAD3(9), SNAI1(1), SNAI2(2), SORBS1(11), SRC(3), SSX2IP(4), TCF7(6), TCF7L1(3), TGFBR1(9), TGFBR2(7), TJP1(7), VCL(2), WAS(1), WASF1(3), WASF2(2), WASF3(4), WASL(7), YES1(1)	35457290	395	95	387	119	148	128	71	5	42	1	0.0649	1.000	1.000
339	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CDS1(2), CDS2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), OCRL(9), PI4KA(15), PI4KB(2), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PRKCA(4), PRKCG(10), PTEN(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	38059787	355	93	347	102	146	97	63	2	43	4	0.0382	1.000	1.000
340	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(11), BDKRB2(3), C1QB(1), C1QC(3), C1R(3), C1S(6), C2(4), C3(11), C3AR1(4), C4BPA(7), C5(13), C5AR1(3), C6(13), C7(5), C8A(6), C9(5), CD46(3), CD55(4), CFB(4), CFH(16), CFI(2), CPB2(2), CR1(10), CR2(11), F10(1), F11(4), F12(2), F13A1(10), F13B(5), F2(3), F3(2), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), KNG1(4), MASP1(12), MASP2(4), PLAT(5), PLAU(3), PLAUR(4), PLG(9), PROC(1), PROS1(6), SERPINA1(3), SERPINA5(4), SERPINC1(3), SERPIND1(2), SERPINE1(3), SERPING1(5), TFPI(3), THBD(2), VWF(15)	28178622	338	92	333	111	94	137	67	0	39	1	0.400	1.000	1.000
341	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	105	ABL1(4), ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), ATM(37), ATR(17), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC14A(4), CDC14B(4), CDC16(4), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(4), CDC27(13), CDC6(1), CDC7(3), CDK2(2), CDK4(3), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(25), CUL1(8), DBF4(5), E2F2(1), E2F3(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PKMYT1(1), PLK1(8), PRKDC(18), PTTG1(1), RB1(7), RBL1(5), RBL2(8), RBX1(1), SKP1(1), SKP2(1), SMAD3(9), SMC1A(10), SMC1B(6), TFDP1(4), TGFB1(1), TGFB2(9), WEE1(3), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	42127607	394	91	387	102	111	126	88	7	59	3	0.0569	1.000	1.000
342	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	84	ACVR1(4), ACVR1C(3), ACVR2B(4), ACVRL1(4), AMHR2(2), BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BMPR1A(4), BMPR1B(10), BMPR2(9), CHRD(5), COMP(2), CREBBP(25), CUL1(8), DCN(4), E2F4(1), E2F5(2), EP300(15), FST(3), GDF5(2), GDF6(3), IFNG(1), INHBA(10), INHBB(1), INHBC(3), INHBE(1), LTBP1(9), MAPK1(2), MAPK3(3), NODAL(1), PITX2(2), PPP2CA(1), PPP2CB(2), PPP2R1A(4), PPP2R1B(2), PPP2R2A(1), PPP2R2B(3), PPP2R2C(4), RBL1(5), RBL2(8), RBX1(1), RHOA(5), ROCK1(15), ROCK2(6), RPS6KB1(3), RPS6KB2(2), SKP1(1), SMAD1(2), SMAD3(9), SMAD5(1), SMAD9(3), SMURF1(3), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), THBS1(10), THBS2(15), THBS3(3), THBS4(2), ZFYVE16(12), ZFYVE9(10)	30376866	328	91	323	113	114	103	63	1	47	0	0.523	1.000	1.000
343	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(4), ACTN1(5), ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGEF6(10), ARHGEF7(7), CAV1(1), CDC42(1), CDKN2A(1), CSE1L(4), DOCK1(7), EPHB2(8), FYN(5), GRB2(3), GRB7(1), GRLF1(12), ITGA1(3), ITGA10(7), ITGA11(4), ITGA2(6), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGA7(6), ITGA8(8), ITGA9(6), ITGB3BP(3), MAP3K11(4), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MRAS(1), MYLK(14), MYLK2(3), P4HB(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PIK3CB(2), PLCG1(4), PLCG2(13), PTEN(10), PTK2(5), RAF1(6), RALA(1), RHO(3), ROCK1(15), ROCK2(6), SHC1(3), SOS1(7), SOS2(11), SRC(3), TERF2IP(2), TLN1(7), TLN2(8), VASP(3), WAS(1), ZYX(1)	37149711	339	90	328	127	120	105	58	5	50	1	0.777	1.000	1.000
344	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(22), ABCA10(10), ABCA12(33), ABCA13(40), ABCA3(6), ABCA4(14), ABCA5(17), ABCA6(17), ABCA7(5), ABCA8(17), ABCA9(18), ABCB1(11), ABCB10(3), ABCB11(11), ABCB4(11), ABCB5(14), ABCB6(4), ABCB7(4), ABCB8(5), ABCB9(2), ABCC1(11), ABCC10(7), ABCC11(11), ABCC12(11), ABCC2(14), ABCC3(5), ABCC4(9), ABCC5(7), ABCC6(7), ABCC8(8), ABCC9(11), ABCD1(3), ABCD2(9), ABCD3(3), ABCD4(5), ABCG1(6), ABCG2(9), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(12), TAP1(5), TAP2(5)	37282701	430	88	426	127	129	137	105	2	54	3	0.0385	1.000	1.000
345	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(9), AMY2A(5), AMY2B(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHX58(3), ENPP1(4), ENPP3(4), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), G6PC(4), G6PC2(1), GANC(3), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), IFIH1(5), MGAM(13), MOV10L1(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SI(15), SKIV2L2(3), SMARCA2(10), SMARCA5(7), TREH(2), UGDH(4), UGP2(7), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6), UXS1(7)	38608399	367	85	363	102	118	116	80	0	52	1	0.0846	1.000	1.000
346	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	120	ARAF(3), BID(1), CASP3(2), CD244(3), CD247(2), FAS(2), FASLG(1), FCGR3A(1), FYN(5), GRB2(3), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IFNG(1), IFNGR1(3), IFNGR2(2), ITGAL(8), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KLRC3(3), KLRD1(1), KLRK1(3), LAT(1), LCK(3), LCP2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MICB(3), NCR1(1), NCR3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK1(5), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTK2B(1), PTPN11(5), PTPN6(4), RAF1(6), SH2D1A(2), SH2D1B(1), SH3BP2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(5), SOS1(7), SOS2(11), SYK(3), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFSF10(1), TYROBP(1), ULBP1(2), ULBP2(2), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	34302539	336	85	329	98	115	111	61	2	43	4	0.0494	1.000	1.000
347	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	89	AKT1(2), AKT2(6), AKT3(1), BCL10(3), CARD11(9), CBL(5), CBLB(8), CD247(2), CD28(2), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDC42(1), CDK4(3), CHUK(6), CTLA4(2), FOS(1), FYN(5), GRAP2(5), GRB2(3), ICOS(1), IFNG(1), IKBKB(4), IL10(2), IL2(4), IL4(3), ITK(11), LAT(1), LCK(3), LCP2(3), MALT1(7), MAP3K14(3), MAP3K8(2), NCK1(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCQ(5), PTPN6(4), PTPRC(17), RASGRP1(5), RHOA(5), SOS1(7), SOS2(11), TEC(3), VAV1(13), VAV2(4), VAV3(12), ZAP70(4)	31299437	324	85	319	104	125	105	54	2	36	2	0.239	1.000	1.000
348	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(4), ATM(37), BUB1(6), BUB1B(6), BUB3(2), CCNA1(6), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDAN1(3), CDC14A(4), CDC14B(4), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(4), CDC6(1), CDC7(3), CDH1(5), CDK2(2), CDK4(3), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(2), E2F4(1), E2F5(2), EP300(15), ESPL1(8), GSK3B(8), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MAD1L1(2), MAD2L1(1), MAD2L2(1), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MPEG1(4), MPL(2), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), PLK1(8), PRKDC(18), PTPRA(2), PTTG1(1), RB1(7), RBL1(5), SKP2(1), TBC1D8(5), TFDP1(4), TGFB1(1), WEE1(3)	34063559	282	82	278	73	73	94	67	6	39	3	0.0635	1.000	1.000
349	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(2), BAD(1), BCL2(1), CABIN1(11), CAMK2B(2), CAMK4(3), CD3G(2), CD69(1), CDKN1A(1), CNR1(5), CREBBP(25), CSNK2A1(4), CSNK2B(2), CTLA4(2), EGR2(8), EGR3(2), EP300(15), FCER1A(3), FCGR3A(1), FOS(1), GATA3(4), GATA4(1), GRLF1(12), GSK3A(2), GSK3B(8), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL13(1), IL1B(1), IL2(4), IL2RA(2), IL3(3), IL4(3), IL6(2), IL8(1), ITK(11), KPNA5(4), MAPK14(3), MAPK8(7), MAPK9(5), MEF2A(4), MEF2D(1), MYF5(4), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB2(4), NFKBIB(1), NFKBIE(2), NPPB(1), NUP214(6), OPRD1(1), P2RX7(3), PAK1(5), PIN1(1), PPP3CB(5), PPP3CC(4), PPP3R1(1), PTPRC(17), RELA(2), SLA(4), SP1(2), SP3(3), TGFB1(1), TRAF2(1), TRPV6(11), VAV1(13), VAV2(4), VAV3(12), XPO5(1)	28431776	308	81	304	100	113	90	62	4	39	0	0.202	1.000	1.000
350	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(4), AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(2), ENTPD6(2), ITPA(2), NME6(4), NME7(5), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), PNPT1(10), POLA1(8), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLR1A(10), POLR1B(8), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3A(11), POLR3B(10), POLR3GL(1), POLR3H(1), POLR3K(1), RFC5(3), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TXNRD2(3), TYMS(3), UCK2(1), UMPS(1), UPB1(5), UPP2(2), UPRT(4)	25889475	251	81	247	61	73	96	51	1	30	0	0.00612	1.000	1.000
351	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(5), AGTR2(5), ATP8A1(10), AVPR1A(4), AVPR1B(3), AVPR2(6), BDKRB2(3), BRS3(3), C3AR1(4), CCKAR(2), CCKBR(5), CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR6(2), CCR7(3), CCR8(4), CX3CR1(2), CXCR4(4), EDNRA(4), EDNRB(12), FPR1(2), FSHR(7), GALR1(2), GALT(2), GHSR(5), GNRHR(4), GPR77(2), GRPR(3), LHCGR(4), MC2R(5), MC3R(1), MC4R(4), MC5R(6), NPY1R(4), NPY2R(5), NPY5R(2), NTSR1(1), NTSR2(5), OPRD1(1), OPRK1(5), OPRM1(3), OXTR(3), PPYR1(4), SSTR1(5), SSTR2(3), SSTR4(4), TAC4(1), TACR1(2), TACR2(1), TACR3(7), TRHR(8), TSHR(7)	16042893	210	80	209	82	80	70	48	1	11	0	0.382	1.000	1.000
352	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	80	ANPEP(8), CD14(1), CD19(3), CD1A(3), CD1B(1), CD1C(1), CD1D(2), CD1E(6), CD2(3), CD22(10), CD33(2), CD34(1), CD36(1), CD37(2), CD38(2), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(4), CD55(4), CD7(1), CD8B(2), CD9(1), CR1(10), CR2(11), CSF1(2), CSF1R(3), CSF3R(10), DNTT(7), FCER2(1), FCGR1A(1), FLT3(5), FLT3LG(1), GP5(6), GYPA(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), IL11(1), IL11RA(1), IL1A(1), IL1B(1), IL1R1(4), IL1R2(7), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(6), IL6(2), IL6R(3), IL7(2), IL7R(3), ITGA1(3), ITGA2(6), ITGA2B(4), ITGA3(4), ITGA4(8), ITGA5(7), ITGA6(4), ITGAM(8), ITGB3(9), KIT(8), KITLG(2), MME(10), MS4A1(4), TFRC(3), THPO(2), TPO(11)	25093785	265	79	259	84	100	103	37	4	19	2	0.108	1.000	1.000
353	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(24), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(8), DOT1L(3), EED(2), EHMT1(2), EHMT2(3), EZH1(5), EZH2(4), FBXO11(5), HSF4(1), JMJD6(2), KDM6A(1), MEN1(2), MLL(21), MLL2(17), MLL3(16), MLL4(11), MLL5(17), NSD1(14), OGT(5), PAXIP1(6), PPP1CB(2), PPP1CC(2), PRDM2(15), PRDM7(2), PRDM9(19), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), RBBP5(2), SATB1(2), SETD1A(8), SETD2(16), SETD7(3), SETD8(2), SETDB1(8), SETDB2(3), SETMAR(1), SMYD3(4), STK38(2), SUV39H1(1), SUV39H2(3), SUV420H1(8), SUZ12(3), WHSC1(7), WHSC1L1(4)	37005318	302	77	299	85	112	81	59	2	45	3	0.170	1.000	1.000
354	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(4), CDC40(4), CLK3(3), CLK4(2), COL2A1(9), CPSF1(5), CPSF2(1), CPSF3(2), CPSF4(4), CSTF1(2), CSTF2T(7), CSTF3(4), DDX1(4), DDX20(4), DHX15(3), DHX16(6), DHX38(11), DHX8(6), DHX9(5), DICER1(8), DNAJC8(2), LSM2(1), METTL3(4), NCBP1(6), NCBP2(1), NONO(2), NUDT21(1), NXF1(7), PABPN1(1), PAPOLA(3), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(4), PRPF3(1), PRPF4(4), PRPF4B(9), PRPF8(11), PSKH1(1), PTBP1(1), PTBP2(4), RBM17(2), RBM5(3), RNGTT(6), RNMT(4), RNPS1(1), SF3A1(3), SF3A2(1), SF3A3(1), SF3B1(10), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPA(1), SNRPB(1), SNRPB2(1), SNRPD3(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(9), SRPK2(4), SRRM1(11), SUPT5H(11), TXNL4A(1), U2AF1(2), U2AF2(3), XRN2(8)	33893605	266	77	266	73	85	76	62	3	40	0	0.394	1.000	1.000
355	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(2), AKT2(6), AKT3(1), CASP8(11), CD14(1), CD40(1), CD80(1), CHUK(6), CXCL10(1), CXCL11(3), CXCL9(3), FOS(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(2), IFNB1(1), IKBKB(4), IKBKE(4), IL12A(1), IL12B(2), IL1B(1), IL6(2), IL8(1), IRAK1(1), IRAK4(4), IRF3(2), IRF5(3), LBP(1), LY96(2), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K7(4), MAP3K8(2), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MYD88(2), NFKB1(6), NFKB2(4), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(6), TICAM1(2), TIRAP(1), TLR1(5), TLR2(6), TLR3(5), TLR4(10), TLR5(4), TLR6(2), TLR7(7), TLR8(6), TLR9(7), TOLLIP(1), TRAF3(6), TRAF6(4)	27484924	275	76	273	73	72	95	65	4	36	3	0.0582	1.000	1.000
356	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(3), ALG6(3), CCKBR(5), CCR3(4), CCR5(1), CELSR1(8), CELSR2(9), CELSR3(5), CHRM2(11), CHRM3(4), EDNRA(4), EMR2(6), EMR3(8), FSHR(7), GHRHR(2), GNRHR(4), GPR116(11), GPR132(1), GPR133(8), GPR143(2), GPR17(1), GPR18(2), GPR55(1), GPR56(2), GPR61(4), GPR77(2), GPR84(6), GPR88(1), GRM1(12), GRPR(3), HRH4(2), LPHN2(13), LPHN3(17), NTSR1(1), OR8G2(1), P2RY13(2), PTGFR(7), SMO(1), SSTR2(3), TAAR5(6), TSHR(7), VN1R1(4)	20109891	204	75	199	83	80	62	40	5	17	0	0.673	1.000	1.000
357	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), AKT1(2), AKT2(6), AKT3(1), APAF1(8), ATM(37), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CAPN1(2), CAPN2(6), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), CSF2RB(7), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL3(3), IRAK1(1), IRAK2(8), IRAK3(3), IRAK4(4), MAP3K14(3), MYD88(2), NFKB1(6), NFKB2(4), NTRK1(6), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKACA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(6), TNFRSF10D(1), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF2(1)	25399853	256	74	251	65	82	83	47	0	40	4	0.0345	1.000	1.000
358	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	70	AKT1(2), AKT2(6), AKT3(1), BTK(7), FCER1A(3), FYN(5), GAB2(1), GRB2(3), IL13(1), IL3(3), IL4(3), INPP5D(4), LAT(1), LCP2(3), LYN(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), MAPK9(5), MS4A2(3), PDK1(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PRKCA(4), PRKCD(3), PRKCE(6), RAF1(6), SOS1(7), SOS2(11), SYK(3), VAV1(13), VAV2(4), VAV3(12)	21682149	232	74	224	60	86	66	48	3	27	2	0.0187	1.000	1.000
359	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(2), BMP5(5), BMP6(3), BMP7(6), BMP8A(1), BTRC(5), CSNK1A1(2), CSNK1A1L(5), CSNK1D(4), CSNK1G1(1), CSNK1G3(3), DHH(1), FBXW11(8), GLI1(4), GLI2(4), GLI3(13), GSK3B(8), HHIP(5), IHH(1), LRP2(52), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), PTCH1(9), PTCH2(6), RAB23(2), SMO(1), STK36(5), SUFU(4), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2), WNT8A(2), WNT9A(2), WNT9B(2), ZIC2(1)	19079203	203	73	201	84	90	57	30	1	25	0	0.804	1.000	1.000
360	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	59	AKT1(2), AKT2(6), AKT3(1), BCL10(3), BLNK(1), BTK(7), CARD11(9), CD19(3), CD22(10), CD72(4), CD79A(3), CD79B(1), CHUK(6), CR2(11), FOS(1), GSK3B(8), IFITM1(1), IKBKB(4), INPP5D(4), LILRB3(2), LYN(4), MALT1(7), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(7), SYK(3), VAV1(13), VAV2(4), VAV3(12)	22467799	238	73	232	62	103	70	35	1	27	2	0.00597	1.000	1.000
361	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(1), CHUK(6), CREB1(1), DAXX(1), FOS(1), GRB2(3), IKBKB(4), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K5(4), MAP2K6(3), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K14(3), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K6(6), MAP3K7(4), MAP3K8(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(4), MAP4K4(8), MAP4K5(2), MAPK1(2), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK4(1), MAPK6(3), MAPK7(3), MAPK8(7), MAPK9(5), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), MKNK2(3), NFKB1(6), PAK1(5), PAK2(3), RAF1(6), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA5(6), RPS6KB1(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	29367222	277	73	272	75	93	81	60	4	39	0	0.0499	1.000	1.000
362	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(15), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), ADIPOR1(1), ADIPOR2(3), AKT1(2), AKT2(6), AKT3(1), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(6), CPT1A(6), CPT1B(5), CPT2(2), G6PC(4), G6PC2(1), IKBKB(4), IRS1(8), IRS4(15), JAK1(4), JAK2(9), JAK3(8), LEP(1), LEPR(9), MAPK10(8), MAPK8(7), MAPK9(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), NPY(2), PCK1(3), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3), PRKAG3(6), PRKCQ(5), PTPN11(5), RELA(2), RXRA(1), RXRB(3), RXRG(4), SLC2A1(1), SLC2A4(4), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1)	26671536	245	71	243	81	74	89	47	5	28	2	0.360	1.000	1.000
363	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	CPEB1(5), EGFR(11), ERBB2(10), ERBB4(21), ETS1(1), ETS2(3), ETV6(5), FMN2(7), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), NOTCH2(13), NOTCH3(15), NOTCH4(7), PIWIL1(8), PIWIL2(10), PIWIL3(10), PIWIL4(8), RAF1(6), SOS1(7), SOS2(11), SPIRE1(3), SPIRE2(1)	16351262	174	70	169	50	55	65	37	3	14	0	0.128	1.000	1.000
364	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	66	AKT1(2), AKT2(6), AKT3(1), BAD(1), CASP9(2), CDC42(1), KDR(10), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK12(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NOS3(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLCG1(4), PLCG2(13), PPP3CA(3), PPP3CB(5), PPP3CC(4), PPP3R1(1), PPP3R2(1), PRKCA(4), PRKCG(10), PTGS2(3), PTK2(5), RAF1(6), SH2D2A(2), SHC2(1), SPHK1(1), SPHK2(1), SRC(3), VEGFA(2)	22024289	185	70	180	65	86	40	29	0	28	2	0.442	1.000	1.000
365	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(1), ADAM17(7), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), CASP3(2), CDC42(1), CHUK(6), CSK(3), EGFR(11), F11R(1), GIT1(3), HBEGF(1), IGSF5(8), IKBKB(4), IL8(1), JAM3(3), LYN(4), MAP3K14(3), MAPK10(8), MAPK12(2), MAPK13(1), MAPK14(3), MAPK8(7), MAPK9(5), MET(5), NFKB1(6), NFKB2(4), NOD1(4), PAK1(5), PLCG1(4), PLCG2(13), PTPN11(5), PTPRZ1(17), RELA(2), SRC(3), TCIRG1(2), TJP1(7)	22242343	212	70	209	51	75	64	47	2	23	1	0.0144	1.000	1.000
366	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	45	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2(1), BCR(7), BLNK(1), BTK(7), CD19(3), CD22(10), CR2(11), CSK(3), DAG1(5), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), INPP5D(4), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), MAP4K1(3), MAPK1(2), MAPK3(3), NFATC1(2), NFATC2(5), PDK1(2), PIK3CD(3), PIK3R1(10), PLCG2(13), PPP1R13B(6), PPP3CA(3), PPP3CB(5), PPP3CC(4), PTPRC(17), RAF1(6), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	22149233	252	70	246	57	96	75	40	2	36	3	0.000514	1.000	1.000
367	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(2), ACTR3(3), AKT1(2), AKT2(6), AKT3(1), ANGPTL2(8), ARHGAP4(1), ARHGEF11(11), BTK(7), CDC42(1), CFL1(1), GDI1(1), GDI2(1), INPPL1(4), ITPR1(19), ITPR2(18), ITPR3(12), LIMK1(5), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PDK1(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PITX2(2), PPP1R13B(6), PTEN(10), RACGAP1(2), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), SAG(1), WASF1(3), WASL(7)	21046177	227	70	224	61	82	70	36	1	34	4	0.0358	1.000	1.000
368	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCL2L1(1), CDC42(1), CDK2(2), CDKN1B(3), CDKN2A(1), CREB1(1), CREB3(3), CREB5(4), EBP(2), ERBB4(21), F2RL2(3), GAB1(6), GRB2(3), GSK3A(2), GSK3B(8), IGF1(2), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), MET(5), NOLC1(8), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PPP1R13B(6), PREX1(16), PTEN(10), PTK2(5), PTPN1(5), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SHC1(3), SLC2A4(4), SOS1(7), SOS2(11), TSC1(4), TSC2(2), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	23853767	249	70	244	85	79	85	44	4	36	1	0.523	1.000	1.000
369	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	56	AXIN1(2), CCND2(1), CCND3(1), DVL2(9), DVL3(4), FBXW2(3), FZD1(1), FZD10(6), FZD2(2), FZD3(13), FZD6(6), FZD7(3), FZD8(1), GSK3B(8), LDLR(5), MAPK10(8), MAPK9(5), PAFAH1B1(3), PLAU(3), PPP2R5C(3), PPP2R5E(2), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCI(4), PRKCQ(5), PRKD1(15), RHOA(5), SFRP4(4), TCF7(6), WNT1(1), WNT10B(4), WNT11(3), WNT16(2), WNT2(1), WNT2B(3), WNT3(4), WNT4(1), WNT5A(3), WNT6(1), WNT7A(2), WNT7B(2)	16089302	181	70	177	57	74	54	28	1	24	0	0.0792	1.000	1.000
370	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	APAF1(8), ATM(37), ATR(17), BAI1(2), BAX(1), BID(1), CASP3(2), CASP8(11), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(7), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(3), CDK2(2), CDK4(3), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DDB2(1), EI24(1), FAS(2), GTSE1(2), IGF1(2), IGFBP3(4), MDM2(4), MDM4(3), PPM1D(4), PTEN(10), RCHY1(2), RFWD2(5), RPRM(1), RRM2(2), SERPINB5(2), SERPINE1(3), SESN1(2), SESN2(4), SESN3(6), SIAH1(1), STEAP3(1), THBS1(10), TNFRSF10B(6), TP53I3(2), TSC2(2), ZMAT3(5)	20454870	199	69	195	43	51	79	37	1	28	3	0.0145	1.000	1.000
371	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	39	AKT1(2), ASAH1(3), ATF1(2), CREB1(1), CREB3(3), CREB5(4), CREBBP(25), CRKL(2), DAG1(5), EGR1(3), EGR2(8), EGR3(2), FRS2(4), GNAQ(4), MAP1B(30), MAPK1(2), MAPK10(8), MAPK3(3), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), NTRK1(6), OPN1LW(1), PIK3C2G(9), PIK3CD(3), PIK3R1(10), PTPN11(5), RPS6KA3(5), SHC1(3), SRC(3), TERF2IP(2)	14786920	174	69	170	55	48	53	37	2	31	3	0.247	1.000	1.000
372	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(37), CCNA1(6), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(2), CCNH(2), CDC25A(2), CDK2(2), CDK4(3), CDK7(1), CDKN1A(1), CDKN1B(3), CDKN2A(1), CDKN2C(1), CREB3(3), CREB3L1(3), CREB3L3(3), CREB3L4(1), E2F2(1), E2F3(2), E2F4(1), E2F5(2), GBA2(5), MCM3(3), MCM4(4), MCM5(6), MCM6(4), MCM7(3), MDM2(4), MNAT1(1), MYT1(13), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(3), POLA2(2), POLE(21), POLE2(1), RB1(7), RBL1(5), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(17), WEE1(3)	23267349	203	68	199	45	54	77	39	2	28	3	0.0105	1.000	1.000
373	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), AFMID(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), CAT(3), CYP1A1(7), CYP1A2(3), CYP1B1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), INMT(2), KMO(5), KYNU(7), LCMT1(3), LCMT2(2), LNX1(11), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), NFX1(8), OGDH(4), OGDHL(11), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), TDO2(4), TPH1(3), TPH2(8), WARS(2), WARS2(3), WBSCR22(1)	19161892	193	68	191	60	66	67	37	3	20	0	0.229	1.000	1.000
374	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CHPT1(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), ESCO1(11), ESCO2(4), ETNK1(2), ETNK2(2), GNPAT(2), GPAM(3), GPD1(1), GPD1L(3), GPD2(4), LCAT(1), MYST3(18), MYST4(10), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PNPLA3(4), PPAP2B(1), PTDSS1(7), SH3GLB1(4)	21380219	202	68	198	73	73	66	44	1	18	0	0.671	1.000	1.000
375	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(7), ADCY4(9), ADCY6(1), ADCY8(12), CACNA1A(17), CACNA1B(11), GNAS(6), GNAT3(2), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(12), KCNB1(5), PDE1A(4), PLCB2(3), PRKACA(1), PRKACB(1), PRKACG(3), PRKX(2), SCNN1A(3), SCNN1B(4), SCNN1G(5), TAS1R1(7), TAS1R2(7), TAS2R1(2), TAS2R10(6), TAS2R13(3), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(3), TAS2R39(3), TAS2R4(2), TAS2R41(1), TAS2R46(2), TAS2R5(2), TAS2R50(5), TAS2R60(2), TAS2R7(1), TAS2R8(2), TAS2R9(3)	16925044	177	68	174	67	75	61	29	0	12	0	0.545	1.000	1.000
376	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	53	ABP1(1), ACAT1(1), ACAT2(2), ACMSD(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(8), CAT(3), CYP19A1(8), CYP1A1(7), CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(6), CYP4B1(9), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(5), HAAO(2), HADHA(3), KMO(5), KYNU(7), MAOA(3), MAOB(1), SDS(2), TDO2(4), TPH1(3), WARS(2), WARS2(3)	17380276	197	68	196	56	68	69	42	1	16	1	0.116	1.000	1.000
377	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), CARM1(2), DBH(5), DCT(13), DDC(1), ECH1(1), ESCO1(11), ESCO2(4), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), MYST3(18), MYST4(10), PNPLA3(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SH3GLB1(4), TAT(5), TPO(11), TYR(3), TYRP1(2), WBSCR22(1)	18537361	199	67	195	74	69	66	45	4	15	0	0.598	1.000	1.000
378	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	54	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AGK(3), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CEL(1), DAK(4), DGAT2(4), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKI(10), DGKZ(3), GK(3), GK2(6), GLA(4), GLB1(3), GPAM(3), LCT(20), LIPA(1), LIPC(4), LIPF(3), LIPG(2), LPL(6), MGLL(1), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PNPLA3(4), PPAP2B(1)	18567679	206	66	204	66	69	77	43	0	17	0	0.196	1.000	1.000
379	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(13), AR(6), ESR1(12), ESR2(2), ESRRA(3), HNF4A(6), NPM1(1), NR0B1(3), NR1D1(4), NR1D2(6), NR1H3(4), NR1I2(2), NR1I3(3), NR2C2(4), NR2E1(2), NR2F1(3), NR2F2(5), NR2F6(1), NR3C1(4), NR4A1(2), NR4A2(7), NR5A2(4), PGR(4), PPARA(1), PPARD(2), PPARG(1), RARB(9), RARG(5), ROR1(9), RORA(2), RORC(1), RXRA(1), RXRB(3), RXRG(4), THRA(2), THRB(4), VDR(2)	13469659	147	66	145	53	56	46	28	3	14	0	0.487	1.000	1.000
380	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(42), B3GALT4(1), CDR1(2), DGKI(10), FAU(1), IL6ST(3), MRPL19(1), PIGK(4), RPL10(1), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL5(1), RPL6(3), RPL7(1), RPL9(4), RPLP0(2), RPS11(1), RPS13(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS4X(2), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), RPS9(2), RPSA(1), SLC36A2(2), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(2)	16281181	152	66	150	39	52	43	31	3	23	0	0.297	1.000	1.000
381	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(2), AR(6), ASAH1(3), CCL13(1), CCL15(1), DAG1(5), EGFR(11), GNA11(1), GNA15(3), GNAI1(4), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), MAPK10(8), MAPK14(3), PHKA2(6), PIK3CD(3), PIK3R1(10), PITX2(2), PTX3(2), RAF1(6), SRC(3)	13550518	152	64	150	55	65	39	28	0	17	3	0.389	1.000	1.000
382	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(7), CAD(11), CASP10(2), CASP3(2), CASP8(11), CASP8AP2(18), CD7(1), CSNK1A1(2), DAXX(1), DEDD(1), DFFA(3), DIABLO(1), EGFR(11), EPHB2(8), FAF1(4), FAIM2(3), IL1A(1), IL8(1), MAP3K1(8), MAP3K5(6), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5), MET(5), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(17), RALBP1(6), RIPK1(2), ROCK1(15), SMPD1(6), TPX2(8), TRAF2(1), TUFM(1)	22104656	214	64	209	57	66	71	48	3	25	1	0.0963	1.000	1.000
383	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C2(4), AKR1C3(2), AKR1C4(3), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), CYP1A1(7), CYP1A2(3), CYP1B1(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2F1(4), CYP2S1(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(4), GSTA5(2), GSTM2(2), GSTM3(3), GSTM4(2), GSTM5(1), GSTO2(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2A1(8), UGT2A3(7), UGT2B10(1), UGT2B11(6), UGT2B15(2), UGT2B17(7), UGT2B28(3), UGT2B4(3), UGT2B7(6)	17474293	190	63	189	45	47	65	52	1	24	1	0.0267	1.000	1.000
384	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(2), IMPA2(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPP5B(1), INPPL1(4), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MINPP1(1), MIOX(1), OCRL(9), PI4KA(15), PI4KB(2), PIK3C3(7), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(2), PIP5K1C(4), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCD3(2), PLCD4(2), PLCE1(9), PLCG1(4), PLCG2(13), PLCZ1(4), PTEN(10), PTPMT1(2), SYNJ1(11), SYNJ2(6)	22602207	197	62	191	54	78	53	37	2	25	2	0.0549	1.000	1.000
385	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	65	ACAA1(2), ACADL(2), ACADM(6), ACOX1(3), ACOX2(2), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(6), CPT1B(5), CPT2(2), CYP27A1(3), CYP4A11(3), CYP4A22(2), CYP7A1(4), CYP8B1(3), EHHADH(2), FABP1(1), FABP2(2), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FABP7(1), FADS2(4), GK(3), GK2(6), HMGCS2(1), LPL(6), ME1(9), MMP1(2), NR1H3(4), OLR1(2), PCK1(3), PCK2(3), PDPK1(1), PLTP(7), PPARA(1), PPARD(2), PPARG(1), RXRA(1), RXRB(3), RXRG(4), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(3), SLC27A4(1), SLC27A5(4), SLC27A6(9), SORBS1(11), UCP1(1)	20820146	190	62	187	59	59	71	34	6	20	0	0.266	1.000	1.000
386	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	38	AKT1(2), AKT2(6), AKT3(1), BAD(1), BCR(7), BLNK(1), BTK(7), CD19(3), CSK(3), DAG1(5), EPHB2(8), GRB2(3), ITPKB(4), LYN(4), MAP2K1(4), MAP2K2(1), MAPK1(2), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PI3(1), PIK3CD(3), PIK3R1(10), PLCG2(13), PPP1R13B(6), RAF1(6), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SYK(3), VAV1(13)	16120073	161	62	155	39	65	43	31	2	18	2	0.0235	1.000	1.000
387	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(18), ATP4A(10), ATP4B(1), ATP5A1(5), ATP5B(4), ATP5C1(4), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5L(2), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), COX10(2), COX15(3), COX17(1), COX4I1(2), COX4I2(3), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(2), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(2), NDUFA9(3), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(2), NDUFC2(1), NDUFS1(6), NDUFS2(3), NDUFS3(2), NDUFS4(1), NDUFS5(2), NDUFS6(2), NDUFV1(2), NDUFV3(1), PPA1(2), PPA2(3), SDHA(6), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(3), UQCRFS1(1), UQCRH(1)	18080791	181	61	179	44	72	57	35	0	17	0	0.0157	1.000	1.000
388	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	50	ACTA1(4), AGT(5), AKT1(2), CALR(1), CAMK1(3), CAMK1G(5), CAMK4(3), CREBBP(25), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(3), GATA4(1), GSK3B(8), HAND1(2), HAND2(2), IGF1(2), MAP2K1(4), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MEF2C(9), MYH2(12), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NKX2-5(1), NPPA(1), PIK3R1(10), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RAF1(6), RPS6KB1(3), SYT1(1)	15093086	174	61	172	47	65	44	36	1	26	2	0.0424	1.000	1.000
389	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(2), ACTR3(3), ARHGAP4(1), ARHGAP5(9), ARHGAP6(2), ARHGEF1(5), ARHGEF11(11), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(2), BAIAP2(1), CFL1(1), DIAPH1(1), LIMK1(5), MYL2(1), MYLK(14), OPHN1(7), PIP5K1A(3), PIP5K1B(2), PPP1R12B(9), ROCK1(15), SRC(3), TLN1(7), VCL(2)	14629920	120	61	118	36	40	32	24	2	22	0	0.433	1.000	1.000
390	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(2), AKT2(6), AKT3(1), ASAH1(3), DAG1(5), DRD2(5), EGFR(11), EPHB2(8), GRB2(3), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PI3(1), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), RAF1(6), RGS20(4), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT3(2), TERF2IP(2)	17798256	180	61	177	54	76	56	31	1	15	1	0.128	1.000	1.000
391	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	43	CBL(5), CD28(2), CD3D(1), CSK(3), CTLA4(2), DAG1(5), DTYMK(1), EPHB2(8), GRAP2(5), GRB2(3), ITK(11), ITPKB(4), LAT(1), LCK(3), LCP2(3), MAPK1(2), NCK1(1), NFAT5(5), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PLCG1(4), PTPRC(17), RAF1(6), RASGRP1(5), RASGRP2(7), RASGRP3(7), RASGRP4(2), SOS1(7), SOS2(11), VAV1(13), ZAP70(4)	17051780	182	61	178	57	70	64	31	2	15	0	0.297	1.000	1.000
392	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(7), CREBBP(25), CTBP1(1), CTBP2(2), DLL1(4), DLL3(3), DLL4(2), DTX1(4), DTX2(4), DTX3(1), DTX3L(3), DTX4(3), DVL2(9), DVL3(4), EP300(15), HDAC1(2), HDAC2(2), HES1(1), JAG1(8), MAML1(3), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(13), NOTCH3(15), NOTCH4(7), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(2), RBPJ(5), RBPJL(3), SNW1(5)	21455234	174	60	171	66	62	53	31	1	27	0	0.617	1.000	1.000
393	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), BCR(7), CAPN1(2), CAPNS1(1), CAPNS2(1), CAV1(1), CRKL(2), CSK(3), FYN(5), GRB2(3), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MAPK8(7), PPP1R12B(9), PTK2(5), RAF1(6), RAP1A(2), ROCK1(15), SHC1(3), SOS1(7), SRC(3), TLN1(7), VCL(2), ZYX(1)	14719055	131	60	128	36	51	43	25	1	11	0	0.116	1.000	1.000
394	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	AK3(1), CAD(11), CDA(1), CTPS(4), CTPS2(4), DCK(2), DCTD(3), DHODH(4), DPYD(14), DPYS(7), DTYMK(1), ENTPD1(2), ITPA(2), NT5E(3), NT5M(1), POLB(3), POLD1(5), POLD2(1), POLE(21), POLG(5), POLL(1), POLQ(12), POLR1B(8), POLR2A(6), POLR2B(8), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLRMT(1), RRM1(2), RRM2(2), TK1(1), TK2(1), TXNRD1(3), TYMS(3), UCK2(1), UMPS(1), UNG(1), UPB1(5)	18397027	156	60	153	42	47	59	33	1	16	0	0.0786	1.000	1.000
395	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(6), AKT3(1), BRD4(4), CAP1(1), CBL(5), CDC42(1), CDKN2A(1), F2RL2(3), FLOT1(3), GRB2(3), GSK3A(2), GSK3B(8), IGFBP1(2), INPPL1(4), IRS1(8), IRS4(15), LNPEP(8), MAPK1(2), MAPK3(3), PARD3(7), PARD6A(2), PDK1(2), PIK3CD(3), PIK3R1(10), PPYR1(4), PTEN(10), PTPN1(5), RAF1(6), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SERPINB6(2), SHC1(3), SLC2A4(4), SORBS1(11), SOS1(7), SOS2(11), YWHAB(2), YWHAE(3), YWHAH(1), YWHAQ(1)	18197893	195	60	188	52	67	61	35	3	26	3	0.0621	1.000	1.000
396	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	36	AKT1(2), ATF2(1), CDC42(1), DLD(1), DUSP10(5), DUSP4(1), GAB1(6), GCK(2), IL1R1(4), MAP2K5(4), MAP3K1(8), MAP3K10(3), MAP3K11(4), MAP3K12(6), MAP3K13(9), MAP3K2(3), MAP3K3(3), MAP3K4(18), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK10(8), MAPK7(3), MAPK8(7), MAPK9(5), MYEF2(7), NFATC3(5), NR2C2(4), PAPPA(18), SHC1(3), TRAF6(4), ZAK(6)	15660096	165	60	163	40	58	50	29	1	27	0	0.0400	1.000	1.000
397	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(3), AKT1(2), ASAH1(3), CAV3(3), DAG1(5), DLG4(3), EPHB2(8), GNAI1(4), GNAQ(4), ITPR1(19), ITPR2(18), ITPR3(12), KCNJ3(6), KCNJ5(4), KCNJ9(3), MAPK1(2), PITX2(2), PTX3(2), RHO(3), RYR1(25)	12154150	131	60	130	54	63	38	17	0	12	1	0.540	1.000	1.000
398	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	64	APAF1(8), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(3), BID(1), BIRC2(4), BIRC3(7), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CHUK(6), DFFA(3), DFFB(2), FAS(2), FASLG(1), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(3), IRF3(2), IRF4(3), IRF5(3), IRF6(2), MAP3K1(8), MAPK10(8), MDM2(4), NFKB1(6), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(6), TNFRSF1A(1), TNFRSF21(5), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6)	17834534	155	59	153	47	48	50	31	2	24	0	0.373	1.000	1.000
399	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	63	ACSS1(3), ACSS2(6), ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), G6PC2(1), GALM(2), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	18171232	174	59	172	58	57	68	36	1	12	0	0.270	1.000	1.000
400	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(1), CHUK(6), DAXX(1), EGF(3), EGFR(11), ETS1(1), ETS2(3), FOS(1), HOXA7(1), IKBKB(4), MAP2K1(4), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK1(2), MAPK13(1), MAPK14(3), MAPK3(3), MAPK8(7), NFKB1(6), PPP2CA(1), PRKCA(4), PRKCD(3), PRKCE(6), PRKCG(10), PRKCH(3), PRKCQ(5), RAF1(6), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1)	15335125	130	58	129	41	58	34	30	3	5	0	0.179	1.000	1.000
401	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(37), BMPR1B(10), CCND2(1), CDK4(3), CDKN1B(3), DAZL(2), DMC1(4), EGR1(3), ESR2(2), FSHR(7), GJA4(2), INHA(2), LHCGR(4), MLH1(8), MSH5(5), NCOR1(12), NRIP1(6), PGR(4), PRLR(4), PTGER2(1), SMPD1(6), VDR(2), ZP2(7)	11318881	135	58	134	34	36	43	28	2	24	2	0.167	1.000	1.000
402	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(25), DUSP1(2), EHHADH(2), EP300(15), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(3), ME1(9), NCOA1(8), NCOR1(12), NCOR2(2), NR1H3(4), NR2F1(3), NRIP1(6), PDGFA(1), PIK3R1(10), PPARA(1), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), PTGS2(3), RB1(7), RELA(2), RXRA(1), SP1(2), STAT5B(3)	19266360	161	58	160	53	51	45	35	2	25	3	0.489	1.000	1.000
403	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	32	AKT1(2), AKT2(6), AKT3(1), BCR(7), BTK(7), CD19(3), CDKN2A(1), DAPP1(2), FLOT1(3), GAB1(6), ITPR1(19), ITPR2(18), ITPR3(12), LYN(4), PDK1(2), PHF11(2), PITX2(2), PLCG2(13), PPP1R13B(6), PREX1(16), PTEN(10), PTPRC(17), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KB1(3), SAG(1), SYK(3), TEC(3), VAV1(13)	16335413	198	57	193	56	75	60	32	2	27	2	0.0623	1.000	1.000
404	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(9), AMY2A(5), AMY2B(1), ENPP1(4), ENPP3(4), G6PC(4), GANAB(4), GBA3(3), GBE1(5), GCK(2), GPI(2), GUSB(2), GYS1(2), GYS2(11), HK1(6), HK2(3), HK3(5), MGAM(13), PGM1(4), PGM3(5), PYGB(4), PYGL(2), PYGM(4), SI(15), UCHL1(2), UCHL3(2), UGDH(4), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UXS1(7)	17496989	158	57	158	54	52	52	32	0	22	0	0.536	1.000	1.000
405	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3D(1), CD3G(2), FOS(1), FYN(5), GRB2(3), LAT(1), LCK(3), MAP2K1(4), MAP3K1(8), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PIK3R1(10), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), PTPN7(2), RAF1(6), RASA1(9), RELA(2), SHC1(3), SOS1(7), SYT1(1), VAV1(13), ZAP70(4)	14311969	138	56	135	36	55	34	22	1	24	2	0.0741	1.000	1.000
406	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(7), FCER1A(3), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PAK2(3), PIK3R1(10), PLA2G4A(8), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12810845	129	55	125	30	48	31	25	1	22	2	0.0322	1.000	1.000
407	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	44	ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), AGPAT1(2), AGPAT3(3), AGPAT4(8), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), GK(3), GLA(4), GLB1(3), LCT(20), LIPC(4), LIPF(3), LIPG(2), LPL(6), PNLIP(7), PNLIPRP1(4), PNLIPRP2(2), PPAP2B(1)	15204241	174	55	172	50	58	60	40	0	16	0	0.0644	1.000	1.000
408	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(3), AASS(9), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(3), GCDH(5), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), HSD3B7(2), NSD1(14), OGDH(4), OGDHL(11), PIPOX(4), PLOD1(4), PLOD2(5), PLOD3(4), RDH11(1), RDH12(3), RDH13(1), SETD1A(8), SETD7(3), SETDB1(8), SHMT1(2), SHMT2(2), SPCS1(1), SPCS3(1), SUV39H1(1), SUV39H2(3), TMLHE(3)	18648707	157	55	154	43	63	40	29	2	23	0	0.0720	1.000	1.000
409	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	15591033	157	55	155	54	58	54	26	1	18	0	0.341	1.000	1.000
410	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	50	ABL1(4), ACTB(2), ARHGEF2(5), ARPC5(1), ARPC5L(2), CD14(1), CDC42(1), CDH1(5), CTTN(1), EZR(2), FYN(5), HCLS1(8), ITGB1(6), KRT18(2), LY96(2), NCK1(1), NCL(3), OCLN(1), PRKCA(4), RHOA(5), ROCK1(15), ROCK2(6), TLR4(10), TLR5(4), TUBA1B(2), TUBA1C(2), TUBA3C(9), TUBA3D(3), TUBA3E(5), TUBA4A(3), TUBA8(2), TUBAL3(4), TUBB(1), TUBB1(2), TUBB2A(3), TUBB2B(3), TUBB3(2), TUBB4(3), TUBB4Q(2), TUBB6(3), TUBB8(3), WAS(1), WASL(7), YWHAQ(1)	15591033	157	55	155	54	58	54	26	1	18	0	0.341	1.000	1.000
411	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(5), ADRA1B(5), ADRA1D(2), ADRA2A(3), ADRB1(3), ADRB3(1), CHRM1(3), CHRM2(11), CHRM3(4), CHRM4(1), CHRM5(2), DRD1(1), DRD2(5), DRD3(3), DRD5(6), HRH1(1), HRH2(4), HTR1A(5), HTR1B(5), HTR1D(2), HTR1E(7), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(8), HTR4(3), HTR5A(5), HTR7(7)	7961104	108	55	107	45	50	34	13	1	10	0	0.406	1.000	1.000
412	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	31	ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), DAG1(5), DGKA(1), ETFA(3), ITGA9(6), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), MAP2K1(4), MAPK1(2), MAPK3(3), NR1I3(3), PAK1(5), PDE3A(5), PDE3B(3), PI3(1), PIK3C2G(9), PIK3CD(3), PIK3R1(10), PLDN(1), RIPK3(4), RPS4X(2), SGCB(4), VASP(3)	14188426	145	55	144	40	51	37	26	3	24	4	0.117	1.000	1.000
413	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(8), BAD(1), BAX(1), BCL2(1), BCL2A1(3), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(2), CASP4(3), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CD40(1), CD40LG(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), FAS(2), FASLG(1), IKBKE(4), NFKB1(6), NGFR(3), NR3C1(4), NTRK1(6), PTPN13(17), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1), TRAF3(6), TRAF6(4)	13783544	129	54	126	53	35	46	25	1	21	1	0.938	1.000	1.000
414	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(11), GNAS(6), GNB1(1), GNGT1(1), GRB2(3), IGF1R(8), ITGB1(6), KLK2(3), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK3(3), MKNK1(1), MKNK2(3), NGFR(3), PDGFRA(17), PPP2CA(1), PTPRR(5), RAF1(6), RPS6KA1(1), RPS6KA5(6), SHC1(3), SOS1(7), SRC(3), STAT3(2)	10779251	107	54	102	37	37	36	24	0	8	2	0.556	1.000	1.000
415	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	15392329	154	54	152	49	51	58	35	0	10	0	0.208	1.000	1.000
416	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPS(3), CDS1(2), CDS2(4), CHAT(6), CHKA(4), CLC(3), CPT1B(5), DGKA(1), DGKB(9), DGKD(12), DGKE(3), DGKG(3), DGKH(10), DGKZ(3), ETNK1(2), GNPAT(2), GPD1(1), GPD2(4), LCAT(1), PAFAH1B1(3), PAFAH2(1), PCYT1A(5), PCYT1B(5), PEMT(1), PISD(2), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PLCB2(3), PLCG1(4), PLCG2(13), PPAP2B(1)	16072307	144	54	139	55	58	40	29	0	17	0	0.761	1.000	1.000
417	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(2), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHB(3), LDHC(2), PDHA1(5), PDHA2(8), PDHB(2), PFKM(4), PFKP(2), PGAM1(3), PGK1(3), PGM1(4), PGM3(5), PKM2(2), TPI1(1)	15392329	154	54	152	49	51	58	35	0	10	0	0.208	1.000	1.000
418	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(8), CREB1(1), FOS(1), GNAI1(4), GNAQ(4), GNAS(6), GNB1(1), GNGT1(1), MAP2K1(4), MAPK3(3), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), RAF1(6), RPS6KA3(5), SYT1(1)	10995702	95	54	94	31	45	21	16	0	13	0	0.268	1.000	1.000
419	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(8), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), CRADD(2), DAXX(1), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K14(3), MAP3K5(6), MAPK8(7), MDM2(4), NFKB1(6), NUMA1(10), PAK2(3), PRKCD(3), PRKDC(18), PSEN1(3), PSEN2(2), PTK2(5), RASA1(9), RB1(7), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF1(2), TRAF2(1)	21467666	186	54	184	54	58	52	48	1	25	2	0.326	1.000	1.000
420	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(5), ADC(1), ALDH4A1(3), ALDH5A1(4), CAD(11), CPS1(14), EPRS(11), GAD1(9), GAD2(4), GCLC(4), GCLM(1), GFPT1(4), GFPT2(4), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), GMPS(5), GOT1(6), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(6), QARS(8)	12633430	126	54	125	33	44	41	28	3	10	0	0.0855	1.000	1.000
421	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(14), COL4A2(4), COL4A3(4), COL4A4(10), COL4A5(19), COL4A6(15), F10(1), F11(4), F12(2), F2(3), F5(21), F8(18), F9(6), FGA(13), FGB(2), FGG(4), KLKB1(6), PROC(1), PROS1(6), SERPINC1(3), SERPING1(5)	14335824	161	54	157	40	34	65	34	1	27	0	0.0552	1.000	1.000
422	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(12), FLT4(5), KDR(10), NOS3(2), PDE3A(5), PDE3B(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKG1(9), PRKG2(5), RYR2(59), SLC7A1(2), SYT1(1), TNNI1(2)	12181223	145	54	145	56	46	54	31	1	13	0	0.691	1.000	1.000
423	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(2), LIMK1(5), MAP3K1(8), MYL2(1), MYLK(14), NCF2(2), PAK1(5), PDGFRA(17), PIK3R1(10), PLD1(11), PPP1R12B(9), RALBP1(6), RPS6KB1(3), TRIO(13), VAV1(13), WASF1(3)	10405348	126	54	123	33	41	36	23	2	21	3	0.126	1.000	1.000
424	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	IMPA1(2), INPP1(2), INPP4A(3), INPP4B(7), INPP5A(2), INPPL1(4), ITPKB(4), MIOX(1), OCRL(9), PIK3C2A(5), PIK3C2B(8), PIK3C2G(9), PIK3CB(2), PIK3CG(14), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(10), PLCD1(7), PLCG1(4), PLCG2(13)	13379209	121	53	119	33	50	38	21	1	11	0	0.162	1.000	1.000
425	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(3), ACTR2(2), ACTR3(3), AKT1(2), ANGPTL2(8), CDC42(1), CFL1(1), FLNA(3), FLNC(13), FSCN3(2), GDI1(1), GDI2(1), LIMK1(5), MYH2(12), MYLK(14), MYLK2(3), PAK1(5), PAK2(3), PAK3(5), PAK6(1), PAK7(7), PFN2(1), RHO(3), ROCK1(15), ROCK2(6), RPS4X(2), VASP(3), WASF1(3), WASL(7)	15004888	135	53	135	37	45	45	23	1	21	0	0.0636	1.000	1.000
426	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(3), ALDH3B2(1), ALDH7A1(3), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(5), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(4), HARS(2), HARS2(4), HDC(8), HNMT(4), LCMT1(3), LCMT2(2), MAOA(3), MAOB(1), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), PRPS1(1), PRPS2(2), UROC1(3), WBSCR22(1)	12371629	118	52	116	43	43	41	23	2	9	0	0.508	1.000	1.000
427	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), ASCC3(19), ATP13A2(3), DDX18(3), DDX19A(3), DDX23(4), DDX4(3), DDX41(2), DDX47(3), DDX50(3), DDX52(2), DDX54(5), DDX55(3), DDX56(5), DHFR(1), DHX58(3), ENTPD7(4), EP400(20), ERCC2(4), ERCC3(7), GGH(1), IFIH1(5), MOV10L1(13), RAD54B(8), RAD54L(3), RUVBL2(1), SETX(20), SKIV2L2(3), SMARCA2(10), SMARCA5(7)	20152341	173	52	170	42	66	47	36	0	23	1	0.0301	1.000	1.000
428	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	72	CALR(1), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(7), CREB1(1), CTSB(5), CTSL1(4), CTSS(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(1), HLA-DQA2(3), HLA-DQB1(1), HLA-DRA(5), HLA-DRB1(2), HLA-DRB5(1), HLA-E(1), HLA-F(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(1), IFI30(1), IFNA1(1), IFNA10(3), IFNA13(2), IFNA16(4), IFNA2(4), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(4), KIR3DL2(4), KIR3DL3(4), KLRC3(3), KLRC4(1), KLRD1(1), LGMN(3), NFYA(3), NFYB(1), NFYC(3), PDIA3(2), RFX5(1), RFXAP(1), TAP1(5), TAP2(5), TAPBP(5)	14541848	143	52	140	42	28	60	27	2	20	6	0.315	1.000	1.000
429	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	27	AKT1(2), AKT2(6), AKT3(1), ANKRD6(5), AXIN1(2), AXIN2(9), CER1(3), CSNK1A1(2), DACT1(6), DKK1(5), DKK2(6), DKK3(2), FSTL1(6), GSK3A(2), GSK3B(8), LRP1(17), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(3), SFRP1(3), TSHB(1), WIF1(2)	10037604	105	52	103	33	48	22	23	0	12	0	0.275	1.000	1.000
430	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(1), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(8), DBH(5), DCT(13), DDC(1), FAH(2), GOT1(6), GOT2(1), GSTZ1(2), HGD(2), HPD(4), MAOA(3), MAOB(1), TAT(5), TPO(11), TYR(3)	9838286	112	52	110	47	39	39	25	1	8	0	0.720	1.000	1.000
431	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(2), ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP2U1(1), CYP4A11(3), CYP4A22(2), CYP4F2(8), CYP4F3(3), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(3), GPX5(4), GPX6(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5)	12411280	108	51	105	38	41	39	19	2	7	0	0.557	1.000	1.000
432	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CD79A(3), CD79B(1), FOS(1), GRB2(3), LYN(4), MAP2K1(4), MAP3K1(8), MAPK14(3), MAPK3(3), MAPK8(7), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), RAF1(6), SHC1(3), SOS1(7), SYK(3), SYT1(1), VAV1(13)	12210400	115	50	113	31	46	33	19	1	16	0	0.112	1.000	1.000
433	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), F2(3), FYN(5), GNA11(1), GNAI1(4), GNB1(1), GNGT1(1), GRB2(3), JAK2(9), MAP2K1(4), MAP2K2(1), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), MAPT(5), MYLK(14), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), STAT1(6), STAT3(2), SYT1(1)	13538537	118	50	116	37	32	43	29	1	11	2	0.473	1.000	1.000
434	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CARM1(2), CREBBP(25), EP300(15), ERCC3(7), ESR1(12), GRIP1(8), GTF2A1(2), GTF2E1(5), GTF2F1(5), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(2), HDAC6(6), MEF2C(9), NCOR2(2), NR0B1(3), NRIP1(6), PELP1(2), POLR2A(6), TBP(1)	14745669	135	50	134	32	52	35	29	4	15	0	0.0204	1.000	1.000
435	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(6), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), ASS1(2), CAD(11), CRAT(3), DARS(4), DARS2(3), DDO(2), DLAT(3), DLD(1), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), NARS2(6), PC(6), PDHA1(5), PDHA2(8), PDHB(2)	12167264	119	50	117	38	53	38	17	0	11	0	0.281	1.000	1.000
436	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(5), ACAA1(2), ACAA2(1), ACADM(6), ACAT1(1), ACAT2(2), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), AOX1(8), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), DLD(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HADHB(2), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), MCCC1(8), MCCC2(2), MCEE(2), MUT(4), OXCT1(3), OXCT2(1), PCCA(9), PCCB(4)	14076184	115	50	114	32	44	39	15	0	17	0	0.175	1.000	1.000
437	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(18), ACACB(15), ACAT1(1), ACAT2(2), ACOT12(9), ACSS1(3), ACSS2(6), ACYP1(2), AKR1B1(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PC(6), PCK1(3), PCK2(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	15099770	151	50	149	45	52	54	23	2	20	0	0.182	1.000	1.000
438	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(5), ACACA(18), ACACB(15), ACADM(6), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(4), ALDH7A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(2), LDHAL6A(3), LDHAL6B(2), LDHB(3), LDHC(2), MCEE(2), MLYCD(1), MUT(4), PCCA(9), PCCB(4), SUCLA2(5), SUCLG1(2)	12959156	133	50	131	30	45	46	21	2	19	0	0.0242	1.000	1.000
439	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(3), ABO(2), B3GALNT1(4), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(4), B3GNT1(2), B3GNT2(2), B3GNT3(1), B3GNT4(1), B3GNT5(1), B4GALNT1(4), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT6(5), FUT1(4), FUT2(1), FUT3(4), FUT6(1), FUT9(5), GCNT2(11), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGX(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(7), ST6GALNAC3(4), ST6GALNAC4(2), ST6GALNAC5(6), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(6), UGCG(2)	15311661	148	50	147	44	57	42	29	1	19	0	0.167	1.000	1.000
440	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(4), CRKL(2), DOCK1(7), FOS(1), GAB1(6), GRB2(3), HGF(8), ITGA1(3), ITGB1(6), MAP2K1(4), MAP2K2(1), MAP4K1(3), MAPK1(2), MAPK3(3), MAPK8(7), MET(5), PAK1(5), PIK3R1(10), PTEN(10), PTK2(5), PTK2B(1), PTPN11(5), RAF1(6), RAP1A(2), RAP1B(2), RASA1(9), SOS1(7), SRC(3), STAT3(2)	13245685	132	50	126	31	35	45	30	2	17	3	0.0564	1.000	1.000
441	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1(3), CAMK1G(5), FPR1(2), GNA15(3), GNB1(1), GNGT1(1), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), NCF1(1), NCF2(2), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), NFKB1(6), PAK1(5), PIK3C2G(9), PLCB1(8), PPP3CA(3), PPP3CB(5), PPP3CC(4), RAF1(6), RELA(2), SYT1(1)	12102955	114	49	113	38	43	29	19	4	19	0	0.370	1.000	1.000
442	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CPT1B(5), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), MAOA(3), MAOB(1), PEMT(1), PISD(2), PLCB2(3), PLCG1(4), PLCG2(13), SARDH(8), SARS(2), SHMT1(2), SHMT2(2), TARS(6)	13399648	117	49	115	43	52	39	12	0	14	0	0.620	1.000	1.000
443	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), ESCO1(11), ESCO2(4), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), MYST3(18), MYST4(10), PNPLA3(4), PRDX6(2), SH3GLB1(4), TAT(5), TPO(11)	10871252	121	49	118	38	55	36	21	1	8	0	0.251	1.000	1.000
444	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(3), ADCY3(2), ADCY9(6), ARF4(3), ARF6(1), ARL4D(1), ATP6V0A1(3), ATP6V0A2(2), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V0D2(9), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(3), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ERO1L(2), GNAS(6), PDIA4(5), PLCG1(4), PLCG2(13), PRKCA(4), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(9)	11864187	107	49	100	32	50	26	21	1	9	0	0.197	1.000	1.000
445	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(5), CALCRL(6), CD97(5), CRHR1(2), CRHR2(5), ELTD1(7), EMR1(8), EMR2(6), GHRHR(2), GLP1R(7), GLP2R(5), GPR64(6), LPHN1(3), LPHN2(13), LPHN3(17), SCTR(3), VIPR1(4), VIPR2(3)	8477772	109	48	106	36	40	36	22	0	11	0	0.272	1.000	1.000
446	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(2), ACAA2(1), ACADL(2), ACADM(6), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(7), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(6), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CPT1A(6), CPT1B(5), CPT2(2), CYP4A11(3), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(5), HADH(1), HADHA(3), HADHB(2), HSD17B10(2), HSD17B4(3), PECI(1)	15621569	143	48	142	45	39	48	35	4	17	0	0.298	1.000	1.000
447	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(2), AKT2(6), AKT3(1), EIF4B(2), FIGF(2), HIF1A(3), IGF1(2), MAPK1(2), MAPK3(3), PDPK1(1), PGF(2), PIK3CB(2), PIK3CD(3), PIK3CG(14), PIK3R1(10), PIK3R2(1), PIK3R3(4), PIK3R5(1), PRKAA1(3), PRKAA2(9), RICTOR(13), RPS6KA1(1), RPS6KA2(10), RPS6KA3(5), RPS6KA6(7), RPS6KB1(3), RPS6KB2(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(6)	15784887	138	48	135	39	50	40	22	0	24	2	0.229	1.000	1.000
448	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	33	AKT1(2), AKT2(6), AKT3(1), ARHGEF11(11), BCL2(1), CDC42(1), DLG4(3), GNA13(2), LPA(10), MAP3K1(8), MAP3K5(6), MAPK8(7), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PI3(1), PIK3CB(2), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RDX(3), ROCK1(15), ROCK2(6), SERPINA4(5), SRF(3)	15274765	137	48	137	44	56	40	21	3	17	0	0.512	1.000	1.000
449	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	30	ACVR1(4), ATF2(1), AXIN1(2), BMP10(3), BMP2(1), BMP4(2), BMP5(5), BMP7(6), BMPR1A(4), BMPR2(9), CHRD(5), FZD1(1), GATA4(1), GSK3B(8), MAP3K7(4), MEF2C(9), MYL2(1), NKX2-5(1), NPPA(1), NPPB(1), RFC1(14), TGFB1(1), TGFB2(9), TGFBR1(9), TGFBR2(7), TGFBR3(8), WNT1(1)	8993333	118	47	116	30	41	34	21	0	22	0	0.0688	1.000	1.000
450	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(7), GABBR1(6), GPRC5A(2), GPRC5B(2), GPRC5C(2), GPRC5D(1), GRM1(12), GRM2(4), GRM3(7), GRM4(7), GRM5(11), GRM7(11), GRM8(9)	6560370	81	47	79	47	35	23	13	1	9	0	0.985	1.000	1.000
451	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(1), AGXT2(5), ALAS1(6), ALAS2(6), AOC2(4), AOC3(4), BHMT(5), CBS(3), CHDH(2), CHKA(4), CTH(2), DAO(6), DLD(1), DMGDH(7), GAMT(1), GARS(3), GATM(1), GCAT(1), GLDC(3), GNMT(1), HSD3B7(2), MAOA(3), MAOB(1), PEMT(1), PHGDH(2), PIPOX(4), PISD(2), PSAT1(4), RDH11(1), RDH12(3), RDH13(1), SARDH(8), SARS(2), SARS2(2), SDS(2), SHMT1(2), SHMT2(2), TARS(6), TARS2(5)	13740624	119	47	119	45	48	44	14	0	13	0	0.687	1.000	1.000
452	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(1), AGMAT(4), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), GAMT(1), GATM(1), GLUD1(2), GOT1(6), GOT2(1), MAOA(3), MAOB(1), NOS1(11), NOS3(2), OAT(1), ODC1(5), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), P4HB(2), RARS(4), SMS(2)	14001130	141	46	139	48	54	47	21	1	18	0	0.436	1.000	1.000
453	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(4), ACO1(4), ACO2(2), CLYBL(6), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(11), PC(6), PCK1(3), PCK2(3), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9465885	80	46	79	30	31	24	16	1	8	0	0.605	1.000	1.000
454	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(18), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(3), ATP6V0A4(7), ATP6V0B(1), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(5), ATP6V1B2(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(2), ATP6V1G3(2), ATP6V1H(3), ATP7A(6), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(2), NDUFB2(1), NDUFB6(1), NDUFS1(6), NDUFS2(3), NDUFV1(2), PPA2(3), SDHA(6), SDHB(2), SHMT1(2), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1)	11710651	111	46	110	31	41	44	17	0	9	0	0.147	1.000	1.000
455	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(6), AKT3(1), DAG1(5), GNAQ(4), ITPKB(4), ITPR1(19), ITPR2(18), ITPR3(12), NFKB1(6), NFKB2(4), NFKBIB(1), NFKBIE(2), PDK1(2), PHKA2(6), PIK3CB(2), PITX2(2), PLD1(11), PLD2(2), PLD3(5), VN1R1(4)	13725495	119	46	119	40	50	35	18	2	13	1	0.373	1.000	1.000
456	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F11(4), F12(2), F13B(5), F2(3), F5(21), F7(3), F8(18), F9(6), FGA(13), FGB(2), FGG(4), LPA(10), PLAT(5), PLAU(3), PLG(9), SERPINB2(5), SERPINE1(3), VWF(15)	11265744	132	45	129	44	33	59	23	0	17	0	0.529	1.000	1.000
457	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(8), AKT1(2), ASAH1(3), GNAI1(4), GNB1(1), GNGT1(1), ITGAV(5), ITGB3(9), MAPK1(2), MAPK3(3), PDGFA(1), PDGFRA(17), PIK3R1(10), PLCB1(8), PRKCA(4), PTK2(5), SMPD1(6), SPHK1(1), SRC(3)	8140745	93	45	92	31	29	23	22	2	14	3	0.572	1.000	1.000
458	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(3), B4GALT1(6), B4GALT2(3), FBP2(3), G6PC(4), GALE(1), GALK2(3), GALT(2), GANAB(4), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), LALBA(1), LCT(20), MGAM(13), PFKM(4), PFKP(2), PGM1(4), PGM3(5)	10141283	101	45	101	34	45	35	18	0	3	0	0.297	1.000	1.000
459	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(2), ACAA2(1), ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), AKR1C4(3), AKR1D1(1), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(2), HSD3B7(2), LIPA(1), RDH11(1), RDH12(3), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(2)	10074856	93	45	93	33	24	39	23	0	7	0	0.519	1.000	1.000
460	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(11), EXTL1(3), EXTL2(6), EXTL3(9), GLCE(6), HS2ST1(4), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(4), NDST2(5), NDST3(10), NDST4(4)	6524111	77	45	76	25	31	21	18	1	6	0	0.396	1.000	1.000
461	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(4), AADAC(3), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(3), ALDH9A1(1), BDH1(1), DDHD1(3), ECHS1(2), EHHADH(2), GAD1(9), GAD2(4), HADH(1), HADHA(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B10(2), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(5), PDHA2(8), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH11(1), RDH12(3), RDH13(1)	13183549	121	45	120	42	49	41	18	0	13	0	0.382	1.000	1.000
462	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(4), ANAPC10(2), ANAPC2(1), ANAPC4(4), ANAPC5(3), ANAPC7(4), BTRC(5), CDC16(4), CDC20(3), CDC23(6), CDC27(13), CUL1(8), CUL2(5), CUL3(1), FBXW11(8), ITCH(3), RBX1(1), SKP1(1), SKP2(1), SMURF1(3), SMURF2(2), UBA1(2), UBE2C(2), UBE2D1(1), UBE2D3(1), UBE2D4(1), UBE2E1(3), UBE2E2(1), VHL(1), WWP1(8), WWP2(4)	12484211	106	45	101	40	31	35	23	0	17	0	0.891	1.000	1.000
463	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(18), ACAT1(1), ACAT2(2), ACYP1(2), ADH5(1), AKR1B1(3), ALDH1A1(4), ALDH1A2(6), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(3), DLD(1), GRHPR(1), LDHA(2), LDHB(3), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(9), ME2(3), ME3(5), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PKM2(2)	11834522	118	45	116	37	42	40	21	1	14	0	0.332	1.000	1.000
464	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	24	ARNT(5), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(12), FLT4(5), HIF1A(3), KDR(10), NOS3(2), PIK3R1(10), PLCG1(4), PRKCA(4), PTK2(5), SHC1(3), VHL(1)	10212285	79	45	77	27	26	22	15	0	14	2	0.650	1.000	1.000
465	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(5), ADSL(7), ADSS(2), AGXT2(5), ASL(2), ASNS(1), ASPA(5), CAD(11), CRAT(3), DARS(4), DDO(2), GAD1(9), GAD2(4), GOT1(6), GOT2(1), GPT2(2), NARS(3), PC(6)	8358460	83	44	82	29	38	30	10	0	5	0	0.428	1.000	1.000
466	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(5), ALDOC(3), DLAT(3), DLD(1), ENO2(3), ENO3(4), FBP2(3), G6PC(4), GCK(2), GOT1(6), GOT2(1), GPI(2), HK1(6), HK2(3), HK3(5), LDHA(2), LDHAL6B(2), LDHB(3), LDHC(2), MDH1(1), MDH2(1), PC(6), PCK1(3), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PFKL(1), PFKM(4), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(7), PKM2(2), TNFAIP1(3), TPI1(1)	13363003	116	44	113	47	47	42	16	0	11	0	0.653	1.000	1.000
467	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	29	AKT1(2), CABIN1(11), CAMK1(3), CAMK1G(5), HDAC5(2), IGF1(2), IGF1R(8), INSR(6), MAP2K6(3), MAPK14(3), MAPK7(3), MEF2A(4), MEF2C(9), MEF2D(1), NFATC1(2), NFATC2(5), PIK3R1(10), PPP3CA(3), PPP3CB(5), PPP3CC(4), SYT1(1), YWHAH(1)	10147055	93	44	91	38	41	21	13	0	16	2	0.660	1.000	1.000
468	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	29	B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(2), GALNT13(5), GALNT14(10), GALNT2(4), GALNT3(4), GALNT5(10), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GALNTL1(5), GALNTL2(8), GALNTL4(2), GALNTL5(8), GCNT1(5), GCNT3(4), GCNT4(7), OGT(5), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(3)	10033615	109	44	108	28	37	41	17	0	14	0	0.201	1.000	1.000
469	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(1), EEF1B2(1), EEF1G(1), EEF2(3), EEF2K(1), EIF2AK1(6), EIF2AK2(1), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4A2(5), EIF4EBP2(1), EIF4G1(9), EIF4G3(11), EIF5(3), EIF5A(2), EIF5B(4), ETF1(5), KIAA0664(4), PABPC1(3), PABPC3(6), PAIP1(4), SLC35A4(2)	13796526	87	44	85	25	26	20	22	5	14	0	0.370	1.000	1.000
470	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	ARHGDIB(3), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CFLAR(3), DAXX(1), DFFA(3), DFFB(2), FAF1(4), LMNB1(4), LMNB2(1), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), PTPN13(17), RB1(7), RIPK2(3), SPTAN1(13)	12074056	124	43	121	36	25	45	27	2	22	3	0.510	1.000	1.000
471	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(3), B4GALT1(6), B4GALT2(3), G6PC(4), G6PC2(1), GALE(1), GALK2(3), GALT(2), GANC(3), GCK(2), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(5), HSD3B7(2), LALBA(1), LCT(20), MGAM(13), PFKL(1), PFKM(4), PFKP(2), PGM1(4), PGM3(5), RDH11(1), RDH12(3), RDH13(1), UGP2(7)	12095602	113	43	113	38	50	39	20	0	4	0	0.275	1.000	1.000
472	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(6), CREBBP(25), DUSP1(2), EP300(15), IKBKB(4), IL1B(1), IL8(1), MAP2K3(6), MAP2K6(3), MAP3K14(3), MAP3K7(4), MAPK14(3), MYD88(2), NFKB1(6), NR3C1(4), RELA(2), TGFBR1(9), TGFBR2(7), TLR2(6)	9509899	109	43	108	34	35	30	28	3	13	0	0.442	1.000	1.000
473	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(2), ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(3), EPX(7), GGT1(3), LPO(3), MPO(5), PLA2G1B(1), PLA2G4A(8), PLA2G6(4), PRDX1(1), PRDX6(2), PTGIS(5), PTGS1(6), PTGS2(3), TBXAS1(5), TPO(11)	8778609	83	43	79	30	42	25	8	2	6	0	0.426	1.000	1.000
474	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), CDK7(1), ERCC3(7), GTF2B(1), GTF2E1(5), GTF2F2(1), GTF2H1(4), GTF2H4(1), MNAT1(1), POLR1A(10), POLR1B(8), POLR2A(6), POLR2B(8), POLR2E(1), POLR2H(1), POLR2I(1), POLR2K(1), POLR3B(10), POLR3D(3), POLR3E(6), POLR3H(1), POLR3K(1), TAF5(4), TAF6(3), TAF7(2), TAF9(1), TBP(1)	11281863	91	43	91	26	33	31	16	1	10	0	0.346	1.000	1.000
475	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(3), EPHB2(8), F2(3), F2RL1(1), F2RL2(3), MAP2K5(4), MAPK1(2), MAPK7(3), MAPK8(7), MYEF2(7), PLD1(11), PLD2(2), PLD3(5), PTK2(5), RAF1(6), RASAL1(2), SRC(3), TEC(3), VAV1(13)	8790202	98	43	96	30	46	30	15	1	6	0	0.254	1.000	1.000
476	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GH1(2), GHR(6), GRB2(3), INSR(6), IRS1(8), JAK2(9), MAP2K1(4), MAPK1(2), MAPK3(3), PIK3R1(10), PLCG1(4), PRKCA(4), PTPN6(4), RAF1(6), RPS6KA1(1), SHC1(3), SLC2A4(4), SOS1(7), SRF(3), STAT5B(3)	9923188	92	42	89	29	31	29	17	0	11	4	0.493	1.000	1.000
477	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(2), ENPP7(2), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(3), SGMS2(6), SGPP1(2), SGPP2(4), SMPD1(6), SMPD3(3), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(8)	11023866	96	42	94	34	35	26	25	2	7	1	0.445	1.000	1.000
478	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(8), POLA2(2), POLB(3), POLD1(5), POLD2(1), POLD3(2), POLE(21), POLE2(1), POLE3(1), POLG(5), POLG2(1), POLH(5), POLI(10), POLK(3), POLL(1), POLM(2), POLQ(12), REV1(7), REV3L(22), RFC5(3)	12961049	115	42	110	34	30	46	23	0	14	2	0.484	1.000	1.000
479	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	ARHGDIB(3), BAG4(2), CASP2(4), CASP3(2), CASP8(11), CRADD(2), DFFA(3), DFFB(2), LMNB1(4), LMNB2(1), MADD(14), MAP3K1(8), MAP3K7(4), MAPK8(7), PAK1(5), PAK2(3), PRKDC(18), RB1(7), RIPK1(2), SPTAN1(13), TNFRSF1A(1), TRADD(1), TRAF2(1)	11732186	118	42	116	40	33	31	30	2	20	2	0.680	1.000	1.000
480	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	39	APAF1(8), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(4), BIRC3(7), CASP2(4), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), FAS(2), FASLG(1), GZMB(2), MAP3K1(8), MAP3K14(3), MAPK10(8), MDM2(4), NFKB1(6), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TRADD(1), TRAF1(2), TRAF2(1)	11306492	94	41	93	31	31	27	23	0	13	0	0.462	1.000	1.000
481	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(5), AGTR1(5), ATF2(1), EGFR(11), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP3K1(8), MAPK1(2), MAPK3(3), MAPK8(7), MEF2A(4), MEF2C(9), MEF2D(1), PAK1(5), PRKCA(4), PTK2(5), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	10469783	103	41	101	29	31	35	22	2	13	0	0.239	1.000	1.000
482	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12), MASP2(4)	6763396	83	41	83	28	26	29	16	0	11	1	0.486	1.000	1.000
483	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(8), BCL2(1), BID(1), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP6(2), CASP7(1), CASP8(11), CASP9(2), CFLAR(3), CHUK(6), DFFA(3), DFFB(2), GAS2(2), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), SPTAN1(13), TNFRSF10A(3), TNFRSF10B(6), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1)	10728802	97	41	96	33	33	34	16	0	13	1	0.649	1.000	1.000
484	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	15	BCL2(1), CREBBP(25), EP300(15), FYN(5), IL7(2), IL7R(3), JAK1(4), JAK3(8), LCK(3), NMI(2), PIK3R1(10), PTK2B(1), STAT5B(3)	8310577	82	41	80	25	26	24	15	1	14	2	0.382	1.000	1.000
485	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(1), ALDH1A3(6), ALDH3A1(2), ALDH3B1(3), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(7), GOT1(6), GOT2(1), HPD(4), LPO(3), MAOA(3), MAOB(1), MPO(5), PRDX1(1), PRDX6(2), TAT(5), TPO(11)	6894282	71	41	69	26	35	22	8	0	6	0	0.418	1.000	1.000
486	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), FUK(1), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), HSD3B7(2), KHK(1), LHPP(2), MPI(1), MTMR1(5), MTMR2(2), MTMR6(4), PFKFB1(7), PFKFB4(2), PFKL(1), PFKM(4), PFKP(2), PHPT1(1), PMM1(3), RDH11(1), RDH12(3), RDH13(1), SORD(2), TPI1(1), TSTA3(1)	12014217	89	40	89	39	36	39	9	0	5	0	0.817	1.000	1.000
487	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(1), ACY1(2), ADC(1), AGMAT(4), ALDH18A1(5), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), AMD1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(5), ASL(2), ASS1(2), CPS1(14), GATM(1), MAOA(3), MAOB(1), NAGS(1), ODC1(5), OTC(5), SAT1(4), SAT2(2), SMS(2)	9502217	96	40	93	30	31	36	16	0	13	0	0.374	1.000	1.000
488	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(1), ARG2(5), ASL(2), ASS1(2), CKM(5), CKMT1B(1), CKMT2(5), CPS1(14), DAO(6), EPRS(11), GAMT(1), GATM(1), GLUD1(2), GLUD2(6), GOT1(6), GOT2(1), LAP3(2), NOS1(11), NOS3(2), OAT(1), OTC(5), P4HA1(1), P4HA2(2), P4HA3(2), RARS(4), RARS2(5)	11450870	107	40	106	37	35	34	20	1	17	0	0.592	1.000	1.000
489	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	21	ACAD8(1), ACAD9(5), ADH1A(1), ADH1B(3), ADH1C(4), ADH4(2), ADH5(1), ADH6(6), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(3), DHRS3(2), ESCO1(11), ESCO2(4), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4)	7754415	88	40	87	31	28	27	26	1	6	0	0.658	1.000	1.000
490	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(5), CFLAR(3), CRKL(2), FOS(1), GRB2(3), IL2RA(2), IL2RB(2), IRS1(8), JAK1(4), JAK3(8), MAPK1(2), MAPK3(3), NMI(2), PIK3R1(10), PTPN6(4), RAF1(6), RPS6KB1(3), SHC1(3), SOS1(7), STAT5B(3), SYK(3)	10794066	89	40	85	29	29	31	12	0	15	2	0.511	1.000	1.000
491	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(2), CAPN2(6), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(11), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(3), MYL2(1), MYLK(14), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PTK2(5), TLN1(7)	10328962	82	40	82	25	34	24	18	0	6	0	0.262	1.000	1.000
492	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN1(1), GRIN2A(21), GRIN2B(10), GRIN2C(4), GRIN2D(5), NOS1(11), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), PRKCA(4), SYT1(1)	7992685	85	40	85	41	41	22	12	0	9	1	0.781	1.000	1.000
493	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(2), AKT2(6), AKT3(1), GRB2(3), IARS(6), IL13RA1(2), IL4(3), IL4R(1), INPP5D(4), JAK1(4), JAK2(9), JAK3(8), PI3(1), PPP1R13B(6), RPS6KB1(3), SERPINA4(5), SHC1(3), SOS1(7), SOS2(11), SRC(3), STAT6(2), TYK2(1)	10962965	91	40	88	30	26	33	16	1	13	2	0.647	1.000	1.000
494	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(9), AGT(5), AGTR2(5), EDN1(1), EDNRA(4), EDNRB(12), EGF(3), EGFR(11), FOS(1), NFKB1(6), PLCG1(4), PRKCA(4), RELA(2)	6649833	67	39	66	21	29	18	14	0	6	0	0.301	1.000	1.000
495	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	12	C1QB(1), C1R(3), C1S(6), C2(4), C3(11), C5(13), C6(13), C7(5), C8A(6), C9(5), MASP1(12)	6207258	79	39	79	26	26	27	14	0	11	1	0.459	1.000	1.000
496	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), GOT1(6), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(9), ME3(5), PGK1(3), PGK2(7), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(5), TKTL2(7), TPI1(1)	6356849	70	39	69	25	25	28	10	0	7	0	0.499	1.000	1.000
497	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(3), CARM1(2), CBS(3), CTH(2), GGT1(3), LCMT1(3), LCMT2(2), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), METTL2B(2), METTL6(8), PAPSS1(2), PAPSS2(4), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), SCLY(1), SEPHS1(3), SEPHS2(3), WBSCR22(1)	7716911	71	38	67	22	23	27	12	2	7	0	0.276	1.000	1.000
498	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(5), ARSB(5), FUCA1(3), GALNS(4), GLB1(3), GNS(4), GUSB(2), HEXB(3), HGSNAT(6), HPSE(2), HPSE2(12), IDS(2), IDUA(1), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NAGLU(4), NEU1(1), NEU2(1), NEU3(1), SPAM1(4)	10888922	102	38	100	35	37	28	24	1	12	0	0.459	1.000	1.000
499	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(2), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CLCA1(6), CLCA2(7), CLCA4(6), CNGA3(6), CNGA4(6), CNGB1(7), GNAL(4), GUCA1A(2), GUCA1B(3), GUCA1C(1), PDC(2), PDE1C(9), PRKACA(1), PRKACB(1), PRKACG(3), PRKG1(9), PRKG2(5), PRKX(2)	9880045	92	38	90	41	28	38	15	1	10	0	0.879	1.000	1.000
500	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(4), BAIAP2(1), CASP1(2), CASP3(2), CASP7(1), CASP8(11), INSR(6), ITCH(3), MAGI1(13), MAGI2(11), RERE(3), WWP1(8), WWP2(4)	7585294	69	38	67	22	21	22	13	0	13	0	0.564	1.000	1.000
501	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	CRKL(2), GNAQ(4), GRB2(3), MAP2K1(4), MAP2K2(1), MAP2K3(6), MAP3K1(8), MAPK1(2), MAPK14(3), MAPK3(3), MAPK8(7), PAK1(5), PLCG1(4), PRKCA(4), PTK2B(1), RAF1(6), SHC1(3), SOS1(7), SRC(3), SYT1(1)	8927176	77	38	75	24	20	27	17	4	9	0	0.447	1.000	1.000
502	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(2), BCL2(1), EGFR(11), IGF1R(8), POLR2A(6), PPP2CA(1), PRKCA(4), RB1(7), TEP1(7), TERF1(1), TERT(2), TNKS(4), XRCC5(6)	8851562	60	38	60	20	27	16	11	1	4	1	0.363	1.000	1.000
503	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	30	CD14(1), CHUK(6), FOS(1), IKBKB(4), IRAK1(1), LY96(2), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), PPARA(1), RELA(2), TIRAP(1), TLR10(4), TLR2(6), TLR3(5), TLR4(10), TLR6(2), TLR7(7), TLR9(7), TOLLIP(1), TRAF6(4)	11116817	107	38	107	33	35	32	27	3	9	1	0.355	1.000	1.000
504	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(5), ACTN2(8), ACTN3(3), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(9), PTK2(5), SPTAN1(13), SRC(3), TLN1(7)	8806884	70	38	70	31	34	22	10	0	3	1	0.850	1.000	1.000
505	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(3), ALDOA(1), ALDOB(5), ALDOC(3), FBP2(3), FPGT(5), GCK(2), GMDS(1), GMPPA(7), HK1(6), HK2(3), HK3(5), KHK(1), MPI(1), PFKFB1(7), PFKFB4(2), PFKM(4), PFKP(2), PMM1(3), SORD(2), TPI1(1)	7700446	67	37	67	25	25	32	7	0	3	0	0.490	1.000	1.000
506	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(2), DLAT(3), DLD(1), DLST(1), FH(1), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(6), PDHA1(5), PDHA2(8), PDHB(2), PDHX(2), PDK1(2), PDK2(2), PDK3(1), PDK4(3), PDP2(1), SDHA(6), SDHB(2), SDHD(1), SUCLA2(5), SUCLG1(2)	9063230	75	37	74	28	32	20	11	0	12	0	0.617	1.000	1.000
507	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	20	AXIN1(2), BTRC(5), CREBBP(25), CSNK1A1(2), CSNK1D(4), CSNK2A1(4), CTBP1(1), FZD1(1), GSK3B(8), HDAC1(2), MAP3K7(4), NLK(1), PPARD(2), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1)	6665815	66	37	66	22	25	12	17	1	11	0	0.461	1.000	1.000
508	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT3(3), AGPAT4(8), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(14), ENPP6(2), PAFAH1B1(3), PAFAH1B3(2), PAFAH2(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), PLD1(11), PLD2(2), PPAP2B(1)	7607372	69	36	66	29	28	24	12	0	5	0	0.850	1.000	1.000
509	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	25	ACOT11(3), ALDH1A3(6), ALDH1B1(7), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(3), ALDH9A1(1), CYP2C19(4), CYP2C9(7), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), HADHA(3), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	9826063	105	36	104	28	40	31	22	1	11	0	0.149	1.000	1.000
510	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	14	ABCA1(22), APOC1(1), APOC2(1), APOE(1), CETP(7), CYP7A1(4), HMGCR(3), LCAT(1), LDLR(5), LIPC(4), LPL(6), LRP1(17), SCARB1(1), SOAT1(1)	8076001	74	36	74	23	31	23	13	1	6	0	0.237	1.000	1.000
511	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CHUK(6), EGR2(8), EGR3(2), GNAQ(4), MAP3K1(8), NFATC1(2), NFATC2(5), NFKB1(6), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), RELA(2), SYT1(1), VIPR2(3)	8744336	76	36	75	24	37	15	12	0	12	0	0.235	1.000	1.000
512	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(2), CHAT(6), DBH(5), DDC(1), GAD1(9), GAD2(4), HDC(8), MAOA(3), PAH(4), SLC18A3(6), TPH1(3)	4579005	51	35	51	24	19	20	9	0	3	0	0.777	1.000	1.000
513	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	12	ACTN1(5), ACTN2(8), ACTN3(3), CSK(3), CTNNA1(12), CTNNA2(12), PECAM1(2), PTK2(5), SRC(3), VCL(2)	5419618	55	35	55	24	31	14	4	1	5	0	0.715	1.000	1.000
514	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(8), GNAS(6), GNB1(1), GNGT1(1), PPP2CA(1), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAG2(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4795268	49	35	48	19	22	15	8	0	4	0	0.737	1.000	1.000
515	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	23	ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(2), DHRS1(1), DHRS2(3), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(11), ESCO2(4), GCDH(5), HADHA(3), ITGB1BP3(1), MYST3(18), MYST4(10), PNPLA3(4), SH3GLB1(4), YOD1(1)	8192288	79	35	78	23	31	21	15	2	10	0	0.308	1.000	1.000
516	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(1), AOC2(4), AOC3(4), CES1(5), CES7(1), DDHD1(3), ESCO1(11), ESCO2(4), LIPA(1), MYST3(18), MYST4(10), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(4)	8037002	80	35	79	27	31	24	17	1	7	0	0.605	1.000	1.000
517	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(2), EIF4A2(5), EIF4B(2), EIF4G1(9), EIF4G2(7), EIF4G3(11), MKNK1(1), PDK2(2), PDPK1(1), PIK3R1(10), PPP2CA(1), PTEN(10), RPS6KB1(3), TSC1(4), TSC2(2)	8074618	70	35	66	21	21	14	15	3	14	3	0.551	1.000	1.000
518	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(1), BLVRA(2), BLVRB(2), CP(6), CPOX(1), EPRS(11), FECH(3), GUSB(2), HCCS(3), HMBS(2), HMOX1(2), HMOX2(3), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(2), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(1), UGT1A9(6), UGT2B15(2), UGT2B4(3), UROD(1), UROS(1)	8606044	67	35	66	19	22	26	12	0	7	0	0.348	1.000	1.000
519	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(5), EGF(3), EGFR(11), GRB2(3), MAP2K1(4), MAPK1(2), MAPK3(3), PTPRB(4), RAF1(6), RASA1(9), SHC1(3), SOS1(7), SPRY1(3), SPRY4(2), SRC(3)	7468458	68	35	66	25	24	21	17	0	6	0	0.767	1.000	1.000
520	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), ACO2(2), DLD(1), DLST(1), FH(1), IDH1(3), IDH2(7), IDH3A(4), IDH3G(2), MDH1(1), MDH2(1), PC(6), PCK1(3), SDHA(6), SDHB(2), SUCLA2(5), SUCLG1(2)	6508105	51	34	51	22	20	17	7	0	7	0	0.783	1.000	1.000
521	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(6), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1B(1), IL1R1(4), IL1RAP(1), IL1RN(3), IL6(2), IRAK1(1), IRAK2(8), IRAK3(3), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP3K7(4), MAPK14(3), MAPK8(7), MYD88(2), NFKB1(6), RELA(2), TGFB1(1), TGFB2(9), TOLLIP(1), TRAF6(4)	9333173	95	34	94	24	36	29	17	3	10	0	0.115	1.000	1.000
522	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(6), CREBBP(25), EP300(15), HDAC3(2), IKBKB(4), NFKB1(6), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4)	7303347	68	34	68	21	26	18	16	1	7	0	0.399	1.000	1.000
523	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(2), IL6R(3), JAK1(4), JAK2(9), JAK3(8), PIAS3(4), PTPRU(12), REG1A(5), SRC(3), STAT3(2)	4903387	52	34	50	20	27	15	3	0	5	2	0.628	1.000	1.000
524	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CDKN1A(1), GNAQ(4), MARCKS(1), NFATC1(2), NFATC2(5), NFATC3(5), NFATC4(5), PLCG1(4), PPP3CA(3), PPP3CB(5), PPP3CC(4), PRKCA(4), SP1(2), SP3(3), SYT1(1)	6628397	49	33	49	17	22	11	5	0	11	0	0.464	1.000	1.000
525	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(5), CCR3(4), CCR4(1), CCR5(1), CCR7(3), CD28(2), CD4(2), CXCR4(4), IFNG(1), IFNGR1(3), IFNGR2(2), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), IL2(4), IL4(3), IL4R(1), TGFB1(1), TGFB2(9)	6210079	67	33	68	31	17	34	9	0	7	0	0.851	1.000	1.000
526	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(1), CDC42(1), CREB1(1), DAXX(1), GRB2(3), HSPB2(2), MAP2K6(3), MAP3K1(8), MAP3K5(6), MAP3K7(4), MAP3K9(4), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(4), MEF2C(9), MEF2D(1), MKNK1(1), PLA2G4A(8), RIPK1(2), RPS6KA5(6), SHC1(3), STAT1(6), TGFB1(1), TGFB2(9), TGFBR1(9), TRADD(1), TRAF2(1)	11292483	103	33	99	33	38	28	23	0	14	0	0.425	1.000	1.000
527	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	23	ASAH1(3), CASP3(2), CERK(1), CREB1(1), CREB3(3), CREB5(4), DAG1(5), EPHB2(8), FOS(1), GNAQ(4), ITPKB(4), MAPK1(2), MAPK10(8), MAPK8(7), MAPK8IP1(2), MAPK8IP3(2), MAPK9(5)	6964587	62	33	61	20	17	17	15	2	11	0	0.370	1.000	1.000
528	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5R1(1), CSNK1D(4), DRD1(1), DRD2(5), GRM1(12), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(3), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3)	4985086	49	32	49	19	22	10	8	2	7	0	0.614	1.000	1.000
529	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(8), C9orf95(1), CD38(2), ENPP1(4), ENPP3(4), NADK(2), NADSYN1(2), NMNAT1(2), NMNAT2(2), NMNAT3(2), NNMT(3), NNT(3), NT5C1A(1), NT5C1B(10), NT5C2(4), NT5C3(2), NT5E(3), NT5M(1), NUDT12(2), QPRT(1)	7094566	59	32	59	24	20	20	11	0	8	0	0.755	1.000	1.000
530	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	ALOX5(4), CYP1A2(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(7), CYP2E1(6), CYP2J2(3), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(8), PLA2G6(4), RDH11(1), RDH12(3), RDH13(1)	7712768	66	31	65	28	26	19	16	0	4	1	0.851	1.000	1.000
531	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(3), B4GALT1(6), B4GALT2(3), B4GALT3(7), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(2), MAN1A1(5), MAN1B1(2), MGAT1(2), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), RPN2(1), ST6GAL1(1)	6311426	48	31	48	17	20	14	10	0	4	0	0.544	1.000	1.000
532	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(5), DYRK1B(4), GLI2(4), GLI3(13), GSK3B(8), PRKACB(1), PRKACG(3), PRKAR1A(5), PRKAR1B(1), PRKAR2B(3), SMO(1), SUFU(4)	5165565	52	31	52	24	22	14	8	0	8	0	0.760	1.000	1.000
533	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	23	ATF1(2), CASP2(4), CHUK(6), CRADD(2), IKBKB(4), MAP2K3(6), MAP2K6(3), MAP3K1(8), MAP3K14(3), MAP4K2(1), MAPK14(3), MAPK8(7), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFRSF1A(1), TRADD(1), TRAF2(1)	7419018	68	31	67	24	26	20	16	3	3	0	0.542	1.000	1.000
534	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GAL3ST1(2), GALC(1), GLA(4), GLB1(3), LCT(20), NEU1(1), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2)	7509328	62	30	62	23	24	18	14	2	4	0	0.562	1.000	1.000
535	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), MTHFR(7), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3599389	43	30	42	16	24	11	5	0	3	0	0.609	1.000	1.000
536	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUD2(6), GLUL(4), HAL(4)	6795823	52	30	52	26	20	17	6	0	9	0	0.969	1.000	1.000
537	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(25), DAXX(1), PAX3(7), PML(4), RB1(7), SIRT1(5), SP100(4), TNFRSF1A(1)	5795535	54	30	53	22	20	12	14	0	7	1	0.758	1.000	1.000
538	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(25), EP300(15), LPL(6), NCOA1(8), NCOA2(7), PPARG(1), RXRA(1)	5671770	63	30	63	20	19	19	17	1	7	0	0.474	1.000	1.000
539	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(7), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(5), HDAC3(2), NCOA1(8), NCOA2(7), NCOA3(11), NCOR2(2), POLR2A(6), RXRA(1), TBP(1)	7853505	58	30	58	21	19	22	13	1	3	0	0.638	1.000	1.000
540	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(8), CREM(4), FHL5(4), FSHB(2), FSHR(7), GNAS(6), XPO1(2)	3027375	33	29	33	12	13	9	7	1	3	0	0.780	1.000	1.000
541	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(1), IARS(6), IARS2(6), ILVBL(2), LARS(5), LARS2(3), PDHA1(5), PDHA2(8), PDHB(2), VARS(1), VARS2(6)	5926588	46	29	45	14	20	12	8	0	6	0	0.498	1.000	1.000
542	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(5), FUCA1(3), GLB1(3), HEXB(3), LCT(20), MAN2B1(5), MAN2B2(1), MAN2C1(6), MANBA(7), NEU1(1), NEU2(1), NEU3(1)	6429363	56	29	56	21	21	16	15	0	4	0	0.632	1.000	1.000
543	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(18), CPT1A(6), LEP(1), LEPR(9), PRKAA1(3), PRKAA2(9), PRKAB1(2), PRKAB2(1), PRKAG1(1), PRKAG2(3)	4755516	53	29	51	20	20	17	10	0	6	0	0.841	1.000	1.000
544	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(8), BIRC2(4), BIRC3(7), CASP10(2), CASP3(2), CASP7(1), CASP8(11), CASP9(2), DFFA(3), DFFB(2), GZMB(2), SCAP(2), SREBF1(1), SREBF2(2)	5895761	49	29	48	16	9	19	10	0	11	0	0.698	1.000	1.000
545	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	12	AKT1(2), BAD(1), CHRNB1(3), CHRNG(3), MUSK(4), PIK3R1(10), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2), YWHAH(1)	4434171	37	28	36	16	12	7	4	1	11	2	0.823	1.000	1.000
546	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(5), CSF1R(3), EGF(3), EGFR(11), GRB2(3), MET(5), PDGFRA(17), PRKCA(4), SH3GLB1(4), SH3GLB2(2), SH3KBP1(4), SRC(3)	6297112	64	28	64	29	20	24	15	0	4	1	0.915	1.000	1.000
547	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	16	AKT1(2), ANXA1(1), GNAS(6), GNB1(1), GNGT1(1), NFKB1(6), NOS3(2), NPPA(1), NR3C1(4), PIK3R1(10), RELA(2), SYT1(1)	5013133	37	28	36	16	15	6	6	0	8	2	0.908	1.000	1.000
548	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(2), CHPT1(1), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PCYT1A(5), PCYT1B(5), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4355980	43	28	42	16	12	14	11	2	4	0	0.632	1.000	1.000
549	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPL13(1), RPL10A(2), RPL10L(2), RPL11(1), RPL18A(1), RPL19(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(2), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(3), RPL7(1), RPL9(4), RPS11(1), RPS13(1), RPS15A(1), RPS16(2), RPS18(2), RPS2(1), RPS20(1), RPS23(4), RPS3(2), RPS9(2), RPSA(1)	6677682	48	28	47	14	14	13	16	1	4	0	0.642	1.000	1.000
550	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3D(1), CD3G(2), ETV5(6), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), IL18R1(10), JAK2(9), MAP2K6(3), MAPK14(3), MAPK8(7), STAT4(3), TYK2(1)	5850565	58	28	59	23	10	25	12	1	8	2	0.889	1.000	1.000
551	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(3), EPX(7), LPO(3), MPO(5), PRDX1(1), PRDX6(2), SHMT1(2), SHMT2(2), TPO(11)	3649672	37	28	36	16	22	8	3	0	4	0	0.737	1.000	1.000
552	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), ESRRA(3), HDAC5(2), MEF2A(4), MEF2C(9), MEF2D(1), PPARA(1), PPP3CA(3), PPP3CB(5), PPP3CC(4), SLC2A4(4), SYT1(1), YWHAH(1)	6378099	57	27	56	28	23	13	12	1	8	0	0.928	1.000	1.000
553	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX1(1), PRDX6(2), TPO(11), TYR(3)	2969504	35	27	34	16	19	7	4	0	5	0	0.786	1.000	1.000
554	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(6), CHKA(4), PCYT1A(5), PDHA1(5), PDHA2(8), PEMT(1), SLC18A3(6)	2206932	37	26	36	17	12	12	10	0	3	0	0.748	1.000	1.000
555	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(6), KHK(1), LCT(20), MPI(1), PGM1(4), PYGL(2), PYGM(4), TPI1(1), TREH(2)	4207884	41	26	41	15	18	12	11	0	0	0	0.527	1.000	1.000
556	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	34	BET1(1), BNIP1(1), GOSR1(3), GOSR2(3), SEC22B(3), SNAP23(1), SNAP25(1), SNAP29(3), STX11(2), STX12(3), STX16(3), STX17(1), STX18(1), STX19(2), STX2(3), STX3(3), STX4(2), STX5(3), STX6(1), STX7(3), STX8(4), TSNARE1(1), VAMP1(1), VAMP3(2), VAMP4(3), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1), YKT6(1)	5222768	60	26	58	17	23	14	9	0	14	0	0.386	1.000	1.000
557	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), RIPK1(2), TANK(6), TNFAIP3(3), TRAF1(2), TRAF2(1), TRAF3(6)	7058355	53	26	52	18	25	13	9	1	5	0	0.501	1.000	1.000
558	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(6), DUSP1(2), IKBKAP(2), IKBKB(4), MAP3K1(8), MAP3K14(3), NFKB1(6), RELA(2), TNFAIP3(3), TRAF3(6), TRAF6(4)	5695880	46	25	46	16	20	13	6	1	6	0	0.678	1.000	1.000
559	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), DDX20(4), E2F4(1), ETS1(1), ETS2(3), ETV3(1), FOS(1), HDAC2(2), HDAC5(2), NCOR2(2), RBL1(5), RBL2(8), SIN3A(10), SIN3B(4)	8384923	49	25	48	27	17	15	9	0	8	0	0.984	1.000	1.000
560	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA3(3), LPO(3), MPO(5), PRDX6(2), TPO(11)	2568071	31	25	30	14	18	7	2	0	4	0	0.776	1.000	1.000
561	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(8), PSMD11(3), PSMD12(4), PSMD13(2), PSMD2(4), PSMD6(3)	5272511	44	25	43	15	15	14	9	2	4	0	0.704	1.000	1.000
562	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(6), IKBKB(4), IL1A(1), IL1R1(4), IRAK1(1), MAP3K1(8), MAP3K14(3), MAP3K7(4), MYD88(2), NFKB1(6), RELA(2), RIPK1(2), TLR4(10), TNFAIP3(3), TNFRSF1A(1), TRADD(1), TRAF6(4)	7688834	62	25	62	18	23	19	14	0	6	0	0.337	1.000	1.000
563	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(4), IFNG(1), IFNGR1(3), IFNGR2(2), IKBKB(4), JAK2(9), LIN7A(2), NFKB1(6), RB1(7), RELA(2), TNFRSF1A(1), USH1C(8), WT1(6)	5681435	55	25	55	18	18	18	9	0	7	3	0.578	1.000	1.000
564	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(5), ASPH(3), COPS5(1), CREB1(1), EDN1(1), EP300(15), HIF1A(3), LDHA(2), NOS3(2), P4HB(2), VHL(1)	5412537	36	24	36	11	12	7	12	1	4	0	0.541	1.000	1.000
565	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	22	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ALPI(2), ALPL(1), ALPP(1), ALPPL2(1), CYP3A4(1), CYP3A43(2), CYP3A5(3), CYP3A7(6), DHRS1(1), DHRS2(3), DHRS3(2), PON1(6), PON2(2), PON3(2)	5529719	42	24	41	17	16	12	8	0	4	2	0.669	1.000	1.000
566	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	17	CARM1(2), DHRS1(1), DHRS2(3), DHRS3(2), LCMT1(3), LCMT2(2), METTL2B(2), METTL6(8), PRMT2(1), PRMT3(3), PRMT5(1), PRMT6(1), PRMT7(3), PRMT8(5), WBSCR22(1)	4413277	38	24	37	15	13	10	7	2	6	0	0.686	1.000	1.000
567	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(2), IL22RA1(1), JAK1(4), JAK2(9), JAK3(8), STAT1(6), STAT3(2), STAT5B(3), TYK2(1)	5899644	38	24	37	17	12	12	7	0	5	2	0.854	1.000	1.000
568	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), CSF1(2), HLA-DRA(5), HLA-DRB1(2), IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL11(1), IL12A(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL7(2), IL8(1), PDGFA(1), TGFB1(1), TGFB2(9)	4252194	49	24	48	22	18	22	3	0	4	2	0.821	1.000	1.000
569	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(3), GGCX(5), GGPS1(1), HMGCR(3), IDI1(1), IDI2(1), LSS(2), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	6145109	39	23	39	14	15	14	6	0	4	0	0.580	1.000	1.000
570	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(6), SUCLA2(5)	2967441	26	23	26	10	11	6	5	0	4	0	0.598	1.000	1.000
571	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA1(1), CA14(2), CA2(1), CA3(2), CA4(1), CA5A(2), CA6(2), CA8(3), CA9(2), CPS1(14), CTH(2), GLS2(2), GLUD1(2), GLUL(4), HAL(4)	6088295	45	23	45	23	17	15	5	0	8	0	0.968	1.000	1.000
572	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(7), ADSS(2), DHFR(1), HPRT1(2), IMPDH1(2), POLB(3), POLD1(5), POLG(5), PRPS2(2), RRM1(2)	3973572	31	23	31	12	15	12	2	0	2	0	0.597	1.000	1.000
573	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(1), ARFGAP3(3), ARFGEF2(8), CLTA(2), COPA(2), GBF1(12), GPLD1(6), KDELR1(2), KDELR2(1), KDELR3(1)	5330256	38	22	37	15	16	9	8	1	4	0	0.733	1.000	1.000
574	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CCR5(1), CXCL12(1), CXCR4(4), FOS(1), GNAQ(4), MAPK14(3), MAPK8(7), PLCG1(4), PRKCA(4), PTK2B(1), SYT1(1)	4288675	31	22	32	12	9	11	5	1	5	0	0.661	1.000	1.000
575	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(3), EGFR(11), MAP2K1(4), MAP3K1(8), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4)	5551282	38	22	38	15	18	10	8	0	2	0	0.641	1.000	1.000
576	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), IMPA2(2), PGM1(4), PGM3(5), TGDS(1)	3737707	30	22	30	12	10	15	4	0	1	0	0.651	1.000	1.000
577	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(6), PGAP1(8), PIGA(1), PIGB(2), PIGG(3), PIGK(4), PIGM(3), PIGN(2), PIGO(3), PIGQ(1), PIGS(2), PIGT(3), PIGU(1), PIGV(2), PIGW(1), PIGX(4)	7584943	49	22	48	19	15	16	12	0	6	0	0.757	1.000	1.000
578	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), ACO2(2), AFMID(1), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4336192	34	22	33	13	13	11	5	2	3	0	0.591	1.000	1.000
579	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), LHPP(2), MTMR1(5), MTMR2(2), MTMR6(4), PHPT1(1), TYR(3)	4892159	35	22	34	19	14	9	8	0	3	1	0.969	1.000	1.000
580	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), ACO2(2), GRHPR(1), HAO1(5), HAO2(4), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(8)	4142137	33	21	32	13	12	11	5	2	3	0	0.644	1.000	1.000
581	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(2), HADH(1), HADHA(3), HSD17B10(2), HSD17B4(3), NTAN1(3), SIRT1(5), SIRT2(2), SIRT5(3), SIRT7(1), VNN2(2)	3817770	29	21	29	12	9	7	5	0	8	0	0.812	1.000	1.000
582	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(5), FBL(3), LDHA(2), LDHB(3), LDHC(2), MAPK14(3), NCL(3)	2872837	29	21	29	14	12	12	4	0	1	0	0.875	1.000	1.000
583	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(3), CBS(3), CTH(2), GGT1(3), MARS(6), MARS2(1), MAT1A(5), MAT2B(3), PAPSS1(2), PAPSS2(4), SCLY(1), SEPHS1(3)	3909947	36	21	33	11	13	15	5	0	3	0	0.339	1.000	1.000
584	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(1), IFNG(1), IL10(2), IL12A(1), IL12B(2), IL13(1), IL15(1), IL16(9), IL1A(1), IL2(4), IL3(3), IL4(3), IL6(2), IL8(1), IL9(2)	3111895	35	20	34	20	13	17	3	0	2	0	0.950	1.000	1.000
585	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(5), GPI(2), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1)	2840683	21	20	20	14	9	7	5	0	0	0	0.967	1.000	1.000
586	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(8), BCL2(1), CASP3(2), CASP9(2), DAXX(1), FAS(2), FASLG(1), HSPB2(2), IL1A(1), MAPKAPK2(3), MAPKAPK3(1)	3613968	28	20	28	11	7	11	6	0	4	0	0.791	1.000	1.000
587	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(3), BFAR(1), CREB1(1), CREB3(3), CREB5(4), MAPK1(2), RAF1(6), SNX13(9), SRC(3), TERF2IP(2)	3117254	34	20	33	12	12	9	7	1	5	0	0.666	1.000	1.000
588	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(9), JAK3(8), MAPK1(2), MAPK3(3), STAT3(2), TYK2(1)	3774782	29	20	28	10	9	9	4	0	5	2	0.629	1.000	1.000
589	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(2), HK1(6), HK2(3), HK3(5), IMPA1(2), PGM1(4), PGM3(5), TGDS(1)	3297472	28	20	28	12	9	15	4	0	0	0	0.723	1.000	1.000
590	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(3), FUT1(4), FUT2(1), FUT9(5), GLA(4), HEXB(3), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3)	3191005	28	19	28	11	9	7	7	0	5	0	0.666	1.000	1.000
591	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(2), HMOX1(2), IL10(2), IL10RA(2), IL10RB(5), IL1A(1), IL6(2), JAK1(4), STAT1(6), STAT3(2)	3881640	30	19	27	18	12	8	7	0	3	0	0.960	1.000	1.000
592	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(8), CD38(2), ENPP1(4), ENPP3(4), NADSYN1(2), NMNAT1(2), NMNAT2(2), NNMT(3), NNT(3), NT5E(3), NT5M(1), QPRT(1)	4823339	35	19	35	17	11	13	6	0	5	0	0.895	1.000	1.000
593	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	13	GALNT1(2), GALNT10(5), GALNT2(4), GALNT3(4), GALNT6(3), GALNT7(3), GALNT8(2), GALNT9(2), GCNT1(5), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2)	4163149	34	19	34	14	13	9	6	0	6	0	0.770	1.000	1.000
594	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	FLT3(5), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(2), IL9(2), KITLG(2), TGFB1(1), TGFB2(9)	2722211	28	18	27	13	9	11	4	0	4	0	0.842	1.000	1.000
595	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(7), CYP2A6(6), CYP2A7(5), XDH(7)	2530820	28	18	28	12	7	11	6	0	4	0	0.762	1.000	1.000
596	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	13	DHRS1(1), DHRS2(3), DHRS3(2), HSD3B7(2), PON1(6), PON2(2), PON3(2), RDH11(1), RDH12(3), RDH13(1)	2690505	23	18	23	10	10	7	2	0	4	0	0.789	1.000	1.000
597	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	17	B3GAT1(1), B3GAT3(1), CHPF(3), CHST11(3), CHST12(3), CHST13(2), CHST14(1), CHSY1(5), DSE(3), UST(1), XYLT1(6), XYLT2(2)	4426588	31	18	31	24	11	12	6	0	2	0	0.995	1.000	1.000
598	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(3), CAMK1G(5), HDAC9(13), MEF2A(4), MEF2C(9), MEF2D(1), YWHAH(1)	2171177	36	18	36	15	9	14	10	0	3	0	0.731	1.000	1.000
599	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12A(1), IL12B(2), IL12RB1(2), IL12RB2(6), JAK2(9), STAT4(3), TYK2(1)	4630119	34	18	35	19	5	17	6	0	4	2	0.987	1.000	1.000
600	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(3), PSMA4(2), PSMA5(1), PSMA7(1), PSMB2(2), PSMB3(1), PSMB5(2), PSMB6(2), PSMC3(3), PSMD14(1), RPN2(1), UBE2A(2), UBE3A(11)	4187494	34	18	34	12	10	11	9	1	3	0	0.695	1.000	1.000
601	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(3), CSF1(2), FCGR3A(1), IL1B(1), IL6R(3), SELL(3), SPN(2), TGFB1(1), TGFB2(9), TNFRSF1A(1), TNFRSF8(2), TNFSF8(1)	4256408	31	18	31	14	8	11	5	0	7	0	0.862	1.000	1.000
602	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(3), DHCR7(2), FDFT1(3), HMGCR(3), HMGCS1(1), IDI1(1), LSS(2), MVK(1), NSDHL(2), PMVK(1), SC4MOL(1), SC5DL(3), SQLE(2)	4199680	25	16	25	10	11	7	5	0	2	0	0.667	1.000	1.000
603	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1(3), CAMK1G(5), CAMK2A(1), CAMK2B(2), CAMK2D(3), CAMK2G(2), CAMK4(3), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1)	3796808	23	15	23	14	7	8	6	0	2	0	0.973	1.000	1.000
604	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(8), GNA12(2), PRKACB(1), PRKACG(3), PRKAG1(1), PRKAR2B(3)	3297771	18	14	18	12	6	6	0	0	6	0	0.983	1.000	1.000
605	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(1), AOC2(4), AOC3(4), CES1(5), ESD(1)	1811673	15	14	15	9	6	7	2	0	0	0	0.922	1.000	1.000
606	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(2), ACP5(1), ACPP(4), ENPP1(4), ENPP3(4), FLAD1(1), TYR(3)	3130454	21	14	20	12	8	5	6	0	1	1	0.954	1.000	1.000
607	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(5), MBTPS1(8), SCAP(2), SREBF1(1), SREBF2(2)	3867883	19	14	19	12	7	6	3	0	3	0	0.953	1.000	1.000
608	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	1990587	16	11	15	13	7	4	2	1	2	0	0.973	1.000	1.000
609	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), HS3ST1(2), HS3ST2(3), HS3ST3B1(2), XYLT1(6), XYLT2(2)	1990587	16	11	15	13	7	4	2	1	2	0	0.973	1.000	1.000
610	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(5), NR1H3(4), NR1H4(2), RXRA(1)	1691276	13	10	13	7	6	3	3	1	0	0	0.804	1.000	1.000
611	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(1), ACAT2(2), BDH1(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(3), OXCT2(1)	2367392	11	10	11	5	6	4	1	0	0	0	0.755	1.000	1.000
612	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS2(2), GLUD1(2), GLUD2(6)	1376434	10	10	10	6	6	3	1	0	0	0	0.926	1.000	1.000
613	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(6), NR3C1(4), PPARG(1), RXRA(1)	1853722	13	9	13	10	1	6	3	0	3	0	0.980	1.000	1.000
614	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(1), IL12A(1), IL12B(2), IL2(4)	951874	10	7	10	6	0	10	0	0	0	0	0.946	1.000	1.000
615	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(1), MST1R(1)	1921111	5	5	5	4	3	2	0	0	0	0	0.935	1.000	1.000
616	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		168558	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
