rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD3E(2), CD3G(1), CD4(1), CD58(1), CD8A(1), IL3(1), IL6(1), KITLG(1)	2644975	10	10	10	1	3	1	1	3	2	0	0.152	0.00782	1.000
2	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(2), IFNG(2), IL12B(2)	1269839	6	6	6	1	2	1	1	0	2	0	0.336	0.00785	1.000
3	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(1), IFNGR2(3), JAK1(2), JAK2(2), STAT1(2)	3472100	12	12	12	0	0	0	3	6	3	0	0.0572	0.0105	1.000
4	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(5), AGT(1), AGTR1(1), AGTR2(1), KNG1(2), NOS3(3), REN(5)	4284311	18	18	17	2	10	2	0	2	4	0	0.0401	0.0119	1.000
5	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(2), GALT(1), TGDS(1), UGDH(1), UXS1(2)	1665957	7	7	7	0	1	1	1	2	2	0	0.142	0.0137	1.000
6	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(1), CD28(1), CD3E(2), CD3G(1), CD4(1)	1364210	6	6	6	1	3	0	1	1	1	0	0.360	0.0156	1.000
7	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	483380	3	3	3	0	0	0	1	1	1	0	0.420	0.0162	1.000
8	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(3)	306178	3	3	3	0	2	1	0	0	0	0	0.300	0.0172	1.000
9	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(3), NR0B2(1), NR1H4(3), RXRA(3)	2319597	11	11	11	2	4	2	0	4	1	0	0.239	0.0223	1.000
10	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), CSF2(2), HLA-DRA(1), IL3(1)	1289447	5	5	5	0	2	1	1	0	1	0	0.202	0.0327	1.000
11	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(2), GALT(1), TGDS(1), UGDH(1), UXS1(2)	2109382	7	7	7	0	1	1	1	2	2	0	0.143	0.0379	1.000
12	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	7	GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GPX1(1), PRKCE(1)	2559398	12	12	12	3	2	3	3	4	0	0	0.354	0.0413	1.000
13	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), RBL1(2), TFDP1(1)	6000334	18	17	18	2	0	2	1	8	7	0	0.216	0.0474	1.000
14	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR2(1), GPR109B(2), GPR161(2), GPR34(2), GPR45(3), GPR65(2), GPR68(1), GPR75(1), GPR81(1)	4176509	15	14	15	3	6	2	2	2	3	0	0.115	0.0490	1.000
15	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1)	3536223	14	14	14	3	2	3	2	5	2	0	0.268	0.0713	1.000
16	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	11	CCNE1(1), CDKN1B(1), CUL1(3), SKP2(1), TFDP1(1), UBE2M(1)	2904181	8	8	8	1	0	1	1	4	2	0	0.347	0.0798	1.000
17	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD2(1), CD33(5), CD5(2), CD7(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(2), IL3(1), ITGAX(6), TLR2(4), TLR7(4), TLR9(2)	7877452	36	34	36	8	16	3	3	10	4	0	0.0885	0.0885	1.000
18	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	IFNG(2), IFNGR1(1), IFNGR2(3), IKBKB(1), JAK2(2), NFKB1(1), NFKBIA(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(1), WT1(2)	6723519	16	16	16	1	2	1	4	7	2	0	0.0524	0.0996	1.000
19	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADS(4), ECHS1(1), HADHA(1)	2299164	6	6	6	1	3	2	1	0	0	0	0.268	0.0997	1.000
20	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(4), AOC2(2), CES1(2)	2567248	8	8	8	1	6	1	0	1	0	0	0.169	0.113	1.000
21	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDK7(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1)	3005083	8	8	8	0	1	2	0	4	1	0	0.183	0.114	1.000
22	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(1), CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1)	2604628	8	8	8	2	3	2	1	1	1	0	0.347	0.117	1.000
23	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7)	5392786	25	22	25	5	13	0	3	6	3	0	0.0767	0.121	1.000
24	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(3), GOT2(1), TAT(2), TYR(1)	1990084	7	6	6	0	4	1	2	0	0	0	0.0774	0.129	1.000
25	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(2), PPARG(1), RETN(1), RXRA(3)	2459401	7	7	7	0	3	1	0	1	2	0	0.110	0.143	1.000
26	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	13	AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), SP1(1)	5928318	17	16	15	3	5	6	2	1	3	0	0.133	0.144	1.000
27	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(1), CD2(1), CD3E(2), CD3G(1), CD4(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(2), STAT4(2), TYK2(3)	6293559	21	19	21	4	12	0	3	3	3	0	0.141	0.146	1.000
28	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(7), JAK1(2), JAK2(2), TYK2(3)	4447774	15	15	15	3	6	1	0	6	2	0	0.276	0.154	1.000
29	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA2(1), IL4R(7), JAK1(2), JAK2(2), TYK2(3)	4447774	15	15	15	3	6	1	0	6	2	0	0.276	0.154	1.000
30	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	8	CCNA1(1), CCNE1(1), CUL1(3), SKP2(1), TFDP1(1)	2900933	7	7	7	1	0	1	0	5	1	0	0.520	0.172	1.000
31	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(2), JAK3(2), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3)	5038232	13	12	13	1	6	2	1	3	1	0	0.0803	0.186	1.000
32	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(3)	4602823	10	10	10	1	3	1	1	3	2	0	0.157	0.188	1.000
33	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PTPN11(4)	3818166	11	11	11	2	4	1	1	4	1	0	0.331	0.189	1.000
34	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), PTK2B(3), SOS1(3), SRC(2)	3752639	9	9	9	1	2	1	1	3	2	0	0.249	0.190	1.000
35	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNA2(1), CCNE1(1), CCNE2(1), CDKN1B(1), CDKN2A(2), E2F4(1), PRB1(1)	3775834	9	9	9	1	1	0	1	5	2	0	0.298	0.207	1.000
36	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(4), PSAT1(2)	2053439	6	5	5	1	4	2	0	0	0	0	0.225	0.215	1.000
37	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(4)	3841359	13	12	13	3	3	2	2	3	3	0	0.373	0.227	1.000
38	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F13A1(3), F2(1), FGA(6), FGB(3), FGG(5), PLAT(3), PLG(2), SERPINB2(1), SERPINE1(2)	5678902	26	24	26	6	7	6	4	8	1	0	0.153	0.227	1.000
39	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), PLCG1(6), RAF1(1), SOS1(3)	6542780	15	14	15	1	3	2	3	5	2	0	0.0549	0.239	1.000
40	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(1)	1012861	3	3	3	0	3	0	0	0	0	0	0.329	0.252	1.000
41	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	7	CCNE1(1), CUL1(3), FBXW7(1), TFDP1(1)	2782560	6	6	6	1	0	1	0	3	2	0	0.521	0.260	1.000
42	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(1), AGTR1(1), CALM1(1), ELK1(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1)	13174734	30	28	28	4	7	9	5	5	4	0	0.0165	0.262	1.000
43	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(5), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(4), LNPEP(2), MME(1), REN(5)	9005394	28	27	27	5	12	4	1	5	6	0	0.0627	0.264	1.000
44	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(2), MYC(1), SP1(1), SP3(1), WT1(2)	2639933	7	7	7	2	1	2	0	2	2	0	0.604	0.276	1.000
45	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(2), TGFBR2(2), TGFBR3(1)	4512797	11	11	11	2	1	3	3	2	2	0	0.183	0.286	1.000
46	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), CYP2E1(1), NR1I3(2), PTGS1(1), PTGS2(1)	2252596	7	7	7	2	1	2	0	1	3	0	0.499	0.291	1.000
47	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	19	AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), TFDP1(1)	6268473	12	12	12	1	2	3	3	3	1	0	0.0942	0.291	1.000
48	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	CDKN1A(1), CDKN1B(1), CDKN2A(2), MDM2(2), PRB1(1)	3180010	7	7	7	1	1	1	1	1	3	0	0.293	0.293	1.000
49	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(1), TAT(2)	1112386	3	3	2	0	2	1	0	0	0	0	0.315	0.296	1.000
50	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(3), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1)	3525953	8	8	8	0	2	1	2	1	2	0	0.116	0.296	1.000
51	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(2), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1)	10215016	23	22	23	2	5	4	2	10	2	0	0.0368	0.300	1.000
52	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1)	2057108	4	4	4	1	0	3	0	0	1	0	0.424	0.312	1.000
53	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUL(1), HAL(2)	8058632	16	15	16	1	6	3	2	3	2	0	0.0287	0.322	1.000
54	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	ASAH1(1), CREB1(1), MAPK1(2), RAF1(1), SRC(2), TERF2IP(1)	4189221	8	8	8	1	1	2	2	1	2	0	0.310	0.324	1.000
55	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(2), IFNGR1(1), JAK1(2), JAK2(2), PTPRU(1), STAT1(2)	4872602	10	10	10	1	1	0	1	5	3	0	0.273	0.329	1.000
56	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	APOBEC1(3), APOBEC2(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1)	3098761	8	8	8	2	4	1	2	1	0	0	0.420	0.360	1.000
57	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP54(2), SRPR(2)	3185647	6	6	6	1	1	1	2	1	1	0	0.384	0.370	1.000
58	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	770612	2	2	2	0	1	1	0	0	0	0	0.440	0.370	1.000
59	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), DAXX(3), DDIT3(1), ELK1(2), MAP3K1(6), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPKAPK2(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), PLA2G4A(3), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(2)	15632928	36	33	34	4	7	12	5	8	4	0	0.00463	0.384	1.000
60	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	CALM1(1), CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1)	12123333	33	29	31	5	9	7	6	5	6	0	0.0211	0.387	1.000
61	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASS(3), KARS(2)	2000648	5	5	4	2	2	0	0	1	2	0	0.892	0.392	1.000
62	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RALBP1(1), RALGDS(2)	6581568	12	12	12	1	3	2	3	2	2	0	0.0844	0.397	1.000
63	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	852776	1	1	1	0	1	0	0	0	0	0	0.782	0.399	1.000
64	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), GOT2(1), PAH(2), TAT(2)	3509035	7	7	6	1	4	1	0	2	0	0	0.329	0.409	1.000
65	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(1), F2(1), F5(6), FGA(6), FGB(3), FGG(5), PROS1(2), SERPINC1(1)	6944066	25	25	25	6	6	6	4	6	3	0	0.158	0.413	1.000
66	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(1), F2RL3(2), GNB1(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1)	10363627	21	19	21	1	8	3	2	6	2	0	0.0116	0.441	1.000
67	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(1), CBS(1), CTH(1), MUT(1)	2084149	4	4	4	1	1	0	1	2	0	0	0.612	0.447	1.000
68	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(5), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1)	5711760	14	14	14	3	4	1	1	3	5	0	0.214	0.448	1.000
69	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(2)	1367854	2	2	2	0	1	0	1	0	0	0	0.486	0.451	1.000
70	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	14	ATM(4), BCL2(2), CCNE1(1), CDKN1A(1), MDM2(2), TIMP3(1)	6618334	11	11	11	1	1	1	2	2	5	0	0.334	0.451	1.000
71	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), IL6(1), LDLR(3)	2259343	5	5	5	2	0	1	0	4	0	0	0.776	0.451	1.000
72	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(3)	2855115	11	10	11	3	5	1	1	2	2	0	0.350	0.454	1.000
73	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(4), ATR(4), CHEK1(3), CHEK2(4), YWHAH(1)	6435332	16	16	14	3	1	2	7	4	2	0	0.255	0.462	1.000
74	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	5	NFYB(1), SP1(1), SP3(1)	2068061	3	3	3	1	0	1	1	1	0	0	0.653	0.470	1.000
75	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	FOS(1), JAK2(2), MAP2K1(1), MAPK3(1), MPL(3), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1), STAT5B(1), THPO(1)	11107614	24	23	24	3	6	3	3	8	4	0	0.0625	0.471	1.000
76	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(2), ADH1C(2)	2384291	6	5	6	2	2	0	0	4	0	0	0.641	0.472	1.000
77	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(2), CALM1(1), CAMK2A(1), CLCA1(2), CLCA2(1), CLCA4(1), CNGA4(3), CNGB1(3), GUCA1C(1), PDC(1), PDE1C(4), PRKG1(1), PRKG2(5), PRKX(1)	12965576	30	29	30	4	13	6	5	3	3	0	0.0155	0.476	1.000
78	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1)	3378974	8	8	8	2	1	3	1	2	1	0	0.382	0.478	1.000
79	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(2)	1647182	3	3	3	1	2	1	0	0	0	0	0.573	0.483	1.000
80	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1)	697988	1	1	1	0	0	0	1	0	0	0	0.685	0.485	1.000
81	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(2), IDI2(1)	1823615	3	3	3	0	1	0	1	1	0	0	0.407	0.486	1.000
82	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), CCND2(2), CDKN1B(1), CEBPB(1), EGR1(3), ESR2(3), FSHR(1), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(2), PGR(5), ZP2(2)	14906594	29	28	29	3	4	8	3	10	4	0	0.0289	0.486	1.000
83	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(2), ATM(4), ATR(4), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), GSK3B(1), SKP2(1), TFDP1(1)	11647881	21	20	21	2	1	3	4	9	4	0	0.0837	0.515	1.000
84	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(3), IRS1(4), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1), SOS1(3), YWHAH(1)	6430948	17	17	17	4	2	2	5	4	4	0	0.400	0.516	1.000
85	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1)	2266494	6	6	6	2	4	0	0	1	1	0	0.591	0.517	1.000
86	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BCL2(2), CASP8AP2(1), CASP9(1), CES1(2)	4767392	7	7	7	1	2	1	0	1	3	0	0.563	0.555	1.000
87	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(2), MAP2K1(1), MAP3K1(6), MAPK3(1), MYC(1), RAF1(1), SOS1(3), STAT1(2), STAT5B(1)	10314751	23	23	21	4	3	5	3	6	6	0	0.170	0.562	1.000
88	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CSK(1), PRKCA(1), PTPRA(3), SRC(2)	3911924	7	7	7	0	3	3	0	1	0	0	0.0572	0.566	1.000
89	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUD2(3), GLUL(1), HAL(2)	9019043	19	17	19	2	8	3	2	4	2	0	0.0410	0.569	1.000
90	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CHEK1(3), WEE1(1), YWHAH(1)	5850893	9	9	9	0	1	0	3	3	2	0	0.135	0.576	1.000
91	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNG(1), MUSK(1), PTK2B(3), SRC(2), TERT(3), YWHAH(1)	5391919	12	12	12	2	5	2	1	2	2	0	0.127	0.581	1.000
92	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	12	ABL1(2), CDKN2A(2), MDM2(2), MYC(1), POLR1A(2), POLR1B(1)	5857893	10	10	10	0	2	1	2	1	4	0	0.0518	0.584	1.000
93	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(1), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), LPA(4), PLAT(3), PLG(2), SERPINB2(1), SERPINE1(2), VWF(7)	14978207	52	45	52	11	16	11	5	13	7	0	0.0232	0.589	1.000
94	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), CALM1(1), CHRM1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PDE2A(1), PDE3A(3), PDE3B(3), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(5), RYR2(30), SLC7A1(1), SYT1(1)	17458784	68	61	68	15	30	13	9	11	5	0	0.00634	0.591	1.000
95	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2)	1636291	2	2	2	0	0	0	0	0	2	0	1.000	0.594	1.000
96	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(3), AKT1(1), BCL2(2), CSF2RB(4), IGF1(2), IGF1R(3), IL3(1), IL3RA(2), KIT(3), KITLG(1), PRKAR1B(1), PRKAR2B(1), YWHAH(1)	7723634	25	22	24	6	10	3	2	6	4	0	0.199	0.609	1.000
97	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	20	GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), PLCG1(6), PRKCA(1), PTK2B(3), PXN(1), RAF1(1)	9109164	18	17	18	2	6	2	3	4	3	0	0.0559	0.610	1.000
98	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), NTRK1(1), PLCG1(6), PRKCA(1), SOS1(3)	5020178	12	11	12	3	2	2	2	4	2	0	0.327	0.613	1.000
99	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1)	5046088	8	8	8	0	2	3	0	1	2	0	0.0653	0.613	1.000
100	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1)	3386319	5	5	5	1	0	1	1	3	0	0	0.496	0.614	1.000
101	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), MAOA(1), MAOB(2), PRPS2(2)	10394313	30	25	30	4	18	3	1	8	0	0	0.0107	0.614	1.000
102	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(4), FOS(1), IL3(1), IL3RA(2), JAK2(2), MAP2K1(1), MAPK3(1), PTPN6(1), RAF1(1), SOS1(3), STAT5B(1)	7500377	18	18	17	4	7	1	2	5	3	0	0.355	0.646	1.000
103	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	SUCLA2(1)	893936	1	1	1	0	0	1	0	0	0	0	0.642	0.654	1.000
104	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOB(1)	1654777	2	2	2	1	0	0	1	1	0	0	0.841	0.656	1.000
105	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASS(3), KARS(2)	2948262	7	7	5	3	2	0	0	2	3	0	0.945	0.658	1.000
106	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), MPO(2), TPO(4), TYR(1)	4122534	9	9	9	2	6	0	1	1	1	0	0.344	0.665	1.000
107	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	PLCD1(3), PRKCA(1), TGM2(1)	2132325	5	5	5	2	2	0	0	3	0	0	0.689	0.671	1.000
108	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2833757	7	7	7	2	4	0	3	0	0	0	0.510	0.676	1.000
109	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2)	2833757	7	7	7	2	4	0	3	0	0	0	0.510	0.676	1.000
110	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	10	ATM(4), CHEK1(3), WEE1(1), YWHAH(1)	6376645	9	9	9	0	1	0	3	3	2	0	0.136	0.683	1.000
111	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(2), EPO(1), FOS(1), JAK2(2), MAP2K1(1), MAPK3(1), PLCG1(6), PTPN6(1), RAF1(1), SOS1(3), STAT5B(1)	9160787	20	19	20	4	5	2	3	7	3	0	0.247	0.685	1.000
112	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), MPO(2), TPO(4)	3579089	8	8	8	2	6	0	0	1	1	0	0.423	0.702	1.000
113	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	4	DCN(1)	1246324	1	1	1	1	0	0	0	0	1	0	0.897	0.702	1.000
114	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), JAK1(2), PTPRU(1), STAT1(2), STAT2(1), TYK2(3)	5325678	10	10	10	2	4	0	1	3	2	0	0.352	0.703	1.000
115	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PLCG1(6), RPS6KA1(1)	6492968	17	16	17	4	4	5	2	3	3	0	0.176	0.706	1.000
116	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(1), FECH(1), HMBS(1), PPOX(1)	3232721	4	4	4	0	0	1	1	1	1	0	0.296	0.713	1.000
117	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), CDKN1B(1), ITGB1(1), MAPK1(2), MAPK3(1), SOS1(3)	6299902	9	9	9	0	1	2	3	3	0	0	0.0558	0.713	1.000
118	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CD28(1), CD4(1), CSF2(2), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7)	8541406	30	26	30	8	14	0	4	7	5	0	0.183	0.714	1.000
119	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BCL2(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1)	8752248	18	17	16	4	5	5	3	1	4	0	0.193	0.720	1.000
120	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GSS(1), GSTA1(2), GSTA4(2)	7139959	11	11	11	0	4	2	1	3	1	0	0.0263	0.725	1.000
121	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3)	3839630	11	11	11	4	6	0	2	2	1	0	0.591	0.732	1.000
122	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(2), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(1), SOAT1(3)	5914289	12	11	12	2	3	2	0	5	2	0	0.332	0.735	1.000
123	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(1), CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), JAK2(2), STAT4(2), TYK2(3)	7963691	22	20	22	5	11	0	4	4	3	0	0.194	0.741	1.000
124	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(1), ME1(1), PC(2), PDHA1(1), SLC25A11(1)	3930491	6	6	6	1	1	1	0	3	1	0	0.464	0.742	1.000
125	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1)	3502193	4	4	4	1	2	0	0	1	1	0	0.687	0.747	1.000
126	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(1), CHST13(1), CHSY1(2), DSE(3), UST(1), XYLT1(1), XYLT2(2)	5973536	11	11	11	1	4	2	1	2	2	0	0.0507	0.748	1.000
127	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	FUCA1(4), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2)	8714792	20	18	20	4	6	4	1	7	2	0	0.118	0.748	1.000
128	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), OPLAH(1)	8797784	14	14	14	0	6	3	1	3	1	0	0.00677	0.753	1.000
129	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ECHS1(1), EHHADH(1), HADHA(1)	3540890	4	4	4	1	0	3	0	0	1	0	0.479	0.754	1.000
130	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), GNB1(1), HTR2C(1), PLCB1(1)	3037326	4	4	4	1	1	1	0	1	1	0	0.668	0.755	1.000
131	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD2(3)	1919184	4	4	4	2	2	0	0	2	0	0	0.828	0.755	1.000
132	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2)	3400299	6	6	6	2	4	1	0	1	0	0	0.458	0.758	1.000
133	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2)	3400299	6	6	6	2	4	1	0	1	0	0	0.458	0.758	1.000
134	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT2(1), PAH(2), TAT(2), YARS2(1)	3698863	7	7	6	2	3	2	0	2	0	0	0.506	0.761	1.000
135	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(1), HADHA(1), HSD17B4(1), MECR(1)	3613794	4	4	4	0	0	2	0	1	1	0	0.300	0.766	1.000
136	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	FOS(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYC(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1)	6579926	11	11	11	2	3	1	2	2	3	0	0.365	0.770	1.000
137	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF2S2(1), EIF2S3(2), GSK3B(1), IGF1(2), IGF1R(3), INPPL1(3)	6444893	13	12	13	3	1	1	2	5	4	0	0.568	0.777	1.000
138	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADS(4), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1)	7143160	12	11	12	2	5	2	2	1	2	0	0.150	0.779	1.000
139	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), JAK1(2), JAK2(2), JAK3(2), PIAS3(1), PTPRU(1), SRC(2), STAT3(1)	6542749	12	12	12	2	3	3	0	5	1	0	0.257	0.779	1.000
140	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1)	3858077	4	4	4	1	1	0	1	1	1	0	0.553	0.782	1.000
141	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(3)	10810211	17	17	17	1	8	3	2	3	1	0	0.0228	0.791	1.000
142	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(1), ALDH3A1(2), MIOX(1), UGDH(1)	3637048	5	5	5	1	3	0	0	1	1	0	0.499	0.792	1.000
143	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(1), MAPK1(2), PRKCA(1)	3788490	5	5	5	1	1	1	1	1	1	0	0.504	0.795	1.000
144	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), DAG1(2)	2600576	3	3	3	0	1	1	1	0	0	0	0.295	0.806	1.000
145	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1), ST3GAL1(1)	5313442	10	9	10	1	6	1	1	1	1	0	0.108	0.807	1.000
146	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1)	12290577	28	26	26	5	5	8	4	7	4	0	0.0669	0.807	1.000
147	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	AKT1(1), CALM1(1), GNB1(1), NFKB1(1), NOS3(3), NPPA(2), SYT1(1)	6102863	10	9	10	1	4	1	1	3	1	0	0.198	0.808	1.000
148	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST6GALNAC4(1), ST8SIA1(1)	2397366	3	3	3	1	1	0	0	1	1	0	0.690	0.809	1.000
149	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1)	4325458	6	6	6	1	2	1	0	3	0	0	0.368	0.810	1.000
150	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), CASP9(1), CHUK(1), GH1(1), NFKB1(1), NFKBIA(1), YWHAH(1)	4407358	7	7	7	2	1	2	1	2	1	0	0.477	0.811	1.000
151	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPP(3), ALPPL2(4)	2803539	8	7	8	3	5	1	1	0	1	0	0.468	0.813	1.000
152	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1)	4757480	6	6	6	0	2	0	2	1	1	0	0.195	0.820	1.000
153	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK2(2), HK3(2), PGM1(1), TGDS(1)	4345095	6	6	6	1	4	1	0	1	0	0	0.316	0.822	1.000
154	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), IL1B(1), MST1(3), MST1R(2)	2795973	7	7	7	3	2	0	1	2	2	0	0.805	0.826	1.000
155	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	CPS1(5), GLS(1)	3298444	6	5	6	2	2	0	2	2	0	0	0.668	0.826	1.000
156	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(1), PSMA5(1), PSMB8(2)	3700473	4	4	4	0	1	2	1	0	0	0	0.207	0.831	1.000
157	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(2), B4GALT2(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1)	6863020	16	16	16	4	7	2	1	4	2	0	0.332	0.832	1.000
158	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	EPX(2), MPO(2), MTHFR(1), TPO(4)	4952370	9	9	9	2	6	0	1	1	1	0	0.368	0.835	1.000
159	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	10	GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), SRC(2)	4289992	12	11	12	4	2	4	2	4	0	0	0.508	0.838	1.000
160	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(2)	6286626	9	9	9	0	4	2	1	1	1	0	0.0370	0.840	1.000
161	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2)	4626691	11	11	11	7	0	3	1	2	5	0	0.955	0.840	1.000
162	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	19	ADCY1(3), AKT1(1), ASAH1(1), GNB1(1), ITGAV(1), ITGB3(1), MAPK1(2), MAPK3(1), PLCB1(1), PRKCA(1), SRC(2)	9126774	15	15	15	2	6	5	1	2	1	0	0.0716	0.848	1.000
163	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(5), ACACB(7), MCAT(1), OXSM(1)	6800035	14	14	14	3	7	2	1	3	1	0	0.230	0.849	1.000
164	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), DDC(3), EPX(2), GOT2(1), MAOA(1), MAOB(2), MPO(2), TAT(2), TPO(4)	9372075	27	25	26	5	17	2	1	6	1	0	0.0466	0.849	1.000
165	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(1), GGT1(1)	2452281	2	2	2	0	0	2	0	0	0	0	0.374	0.854	1.000
166	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(2), PARK2(1)	2719804	3	3	3	0	2	0	0	1	0	0	0.360	0.855	1.000
167	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1)	1380439	1	1	1	0	0	1	0	0	0	0	0.565	0.855	1.000
168	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(3), GNB1(1)	2811420	4	4	4	0	2	1	0	1	0	0	0.269	0.858	1.000
169	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(2), GSK3B(1)	4910905	7	7	7	2	0	1	2	2	2	0	0.630	0.860	1.000
170	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BIRC3(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	3601428	4	4	4	1	1	0	1	2	0	0	0.589	0.861	1.000
171	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	27	ELK1(2), GNB1(1), IGF1R(3), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYC(1), PTPRR(3), RAF1(1), RPS6KA1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1)	12068907	24	24	24	4	6	5	3	7	3	0	0.125	0.861	1.000
172	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT3(2), FUT5(3), FUT6(1)	2174439	7	7	7	3	4	0	0	3	0	0	0.653	0.865	1.000
173	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(3), F2(1), F2RL3(2), GNB1(1), MAP3K7(3), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(3), ROCK1(2)	9435598	18	17	18	3	8	3	1	2	4	0	0.113	0.868	1.000
174	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPT(2), ENPP1(1), TYR(1)	4115504	4	4	4	0	2	0	1	1	0	0	0.301	0.873	1.000
175	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(1), CD3E(2), CD3G(1), GZMB(2), ICAM1(1), ITGB2(5)	3707758	12	12	12	6	4	0	2	2	4	0	0.716	0.874	1.000
176	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	GLS(1), PRODH(1)	2362656	2	2	2	1	1	0	0	1	0	0	0.804	0.876	1.000
177	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP6(2), ACPT(2), ENPP1(1), LHPP(1), MTMR1(2), TYR(1)	6378333	9	9	9	2	5	1	2	1	0	0	0.353	0.877	1.000
178	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	CDKN1A(1), EPO(1), JAK2(2), NFKB1(1), NFKBIA(1)	5401381	6	6	6	0	2	1	0	3	0	0	0.175	0.879	1.000
179	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(1), GSS(1), NFKB1(1), XDH(3)	4251755	6	6	6	2	2	1	0	3	0	0	0.616	0.879	1.000
180	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ECHS1(1), EHHADH(1), HADHA(1)	5171704	9	9	9	3	4	3	0	1	1	0	0.359	0.883	1.000
181	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), TAX1BP3(1), UBE2E3(1), UBE2M(1), UBE3A(1)	4472034	5	5	5	1	2	1	1	0	1	0	0.325	0.886	1.000
182	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), GZMB(2), SCAP(1), SREBF1(1), SREBF2(1)	7811487	9	9	9	1	2	1	2	3	1	0	0.203	0.886	1.000
183	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(1), NDUFA4(1), NDUFS2(1)	2972368	3	3	3	1	0	1	0	1	1	0	0.723	0.886	1.000
184	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(1)	1688651	3	3	3	2	3	0	0	0	0	0	0.800	0.888	1.000
185	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GGT1(1)	1794349	1	1	1	0	0	1	0	0	0	0	0.585	0.893	1.000
186	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(3), CYP11B2(2), HSD11B1(2)	2925973	9	9	9	4	5	3	0	0	1	0	0.545	0.893	1.000
187	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT2(1)	2892853	2	2	2	0	0	1	0	1	0	0	0.539	0.904	1.000
188	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ACACA(5), ACACB(7), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2)	16832110	30	28	30	4	11	7	2	8	2	0	0.0245	0.905	1.000
189	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABP1(4), ALDH1A3(1), ALDH3A1(2), AOC2(2), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HIBCH(1), MLYCD(1)	11483297	20	19	20	3	8	5	0	6	1	0	0.0461	0.909	1.000
190	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(1), RANGAP1(2)	3565182	3	3	3	0	1	0	0	1	1	0	0.404	0.909	1.000
191	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(3), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT8(1)	6025372	10	10	9	2	4	2	0	2	2	0	0.302	0.911	1.000
192	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	BCL2(2), CASP9(1), DAXX(3), IL1A(1), MAPKAPK2(1), MAPKAPK3(1)	4824263	9	8	9	3	1	3	1	2	2	0	0.603	0.911	1.000
193	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	19	CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), GAMT(1), GATM(2), NAGS(1)	7172486	15	15	14	4	6	1	3	5	0	0	0.431	0.912	1.000
194	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS1(1), CSNK1D(1), GSK3B(1)	3999313	6	6	6	2	1	2	1	2	0	0	0.515	0.914	1.000
195	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), PPP1R1B(1)	1624132	2	2	2	2	2	0	0	0	0	0	0.834	0.917	1.000
196	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), IARS(3), IL4R(7), INPP5D(3), JAK1(2), JAK2(2), JAK3(2), NR0B2(1), SOS1(3), SRC(2), STAT6(1), TYK2(3)	14826788	30	30	30	5	12	5	1	10	2	0	0.0641	0.917	1.000
197	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1)	5478131	8	8	8	2	3	1	0	2	2	0	0.506	0.918	1.000
198	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(4), CRY1(1), PER1(1)	3644136	6	6	5	3	1	1	0	1	3	0	0.942	0.919	1.000
199	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2)	5654565	9	8	9	3	4	0	0	5	0	0	0.564	0.920	1.000
200	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	GLI2(3), GLI3(1), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1)	7131126	11	10	11	2	4	1	1	3	2	0	0.306	0.920	1.000
201	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK2(2), HK3(2), PGM1(1), TGDS(1)	4971588	6	6	6	1	4	1	0	1	0	0	0.301	0.923	1.000
202	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(3), FSHR(1)	4070908	4	4	4	0	2	2	0	0	0	0	0.225	0.924	1.000
203	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	FUCA1(4), LCT(3), NEU1(1), NEU2(3), NEU4(2)	7075584	13	11	13	3	4	4	1	3	1	0	0.222	0.927	1.000
204	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	EPX(2), MPO(2), TPO(4)	5043095	8	8	8	2	6	0	0	1	1	0	0.404	0.927	1.000
205	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1)	5583723	7	7	7	0	4	1	0	2	0	0	0.104	0.930	1.000
206	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1)	7707285	8	7	8	0	0	1	2	2	3	0	0.211	0.931	1.000
207	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	11	ARPC2(1), PAK1(1)	3126001	2	2	2	1	0	0	0	0	2	0	1.000	0.932	1.000
208	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(1), ACO1(1), CLYBL(4), DLD(2), IDH3A(1), OGDHL(3), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2)	11361921	20	20	20	4	3	4	1	11	1	0	0.237	0.937	1.000
209	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(1), ALOX5(1), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1)	10138955	23	22	23	5	9	3	2	8	1	0	0.182	0.938	1.000
210	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(5), CPT1A(1), LEPR(1), PRKAG2(1)	6135736	8	8	8	2	4	0	0	2	2	0	0.596	0.939	1.000
211	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT2(1), FUT8(1), ST3GAL1(1)	3343331	3	3	3	0	1	0	0	1	1	0	0.421	0.940	1.000
212	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(3), GNB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1), SRC(2)	8765536	12	12	12	1	5	3	1	3	0	0	0.0641	0.940	1.000
213	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACYP1(1), ECHS1(1), EHHADH(1), HADHA(1)	3315134	4	4	4	2	0	3	0	0	1	0	0.720	0.940	1.000
214	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	ELK1(2), FOS(1), IGF1(2), IGF1R(3), IRS1(4), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	8935599	23	21	23	6	3	3	4	9	4	0	0.420	0.940	1.000
215	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1)	7727374	12	11	10	3	2	5	1	3	1	0	0.302	0.943	1.000
216	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), PDE6A(2), PDE6B(2), SLC6A13(2)	15333172	22	22	22	2	13	6	1	0	2	0	0.00249	0.944	1.000
217	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	F13B(1), HSD17B3(1), HSD17B4(1)	3431425	3	3	3	2	0	2	0	0	1	0	0.812	0.944	1.000
218	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	B2M(1), ITGB1(1), KLRC1(1), KLRC3(4), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PTK2B(3), PTPN6(1), VAV1(4)	6312165	19	16	19	6	5	1	3	5	5	0	0.610	0.949	1.000
219	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(1), FDPS(2), MVD(1), MVK(1)	5653473	5	5	5	0	2	0	2	1	0	0	0.190	0.950	1.000
220	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(2), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(2), MAPK3(1), MET(3), PAK1(1), PTK2B(3), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1)	16898702	35	31	35	5	11	6	4	11	3	0	0.0220	0.952	1.000
221	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(2)	11325625	12	12	12	1	1	1	2	3	5	0	0.244	0.952	1.000
222	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(1)	2393367	1	1	1	0	0	1	0	0	0	0	0.600	0.955	1.000
223	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(1), EPHB1(2), FYN(1), ITGA1(2), ITGB1(1), L1CAM(5), LYN(2), SELP(2)	6695594	16	16	16	5	7	2	5	2	0	0	0.384	0.956	1.000
224	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP4(1), BMP5(4), BMP6(1), BTRC(1), CSNK1D(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(3), GLI3(1), GSK3B(1), HHIP(1), IHH(1), LRP2(17), PRKX(1), PTCH2(2), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	25648508	59	53	59	9	28	8	6	9	8	0	0.00205	0.956	1.000
225	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD1(1), DRD2(1), DRD3(1), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3)	10503835	31	30	31	9	21	5	2	3	0	0	0.0379	0.957	1.000
226	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP6(2), ACPT(2), ALPI(1), ALPP(3), ALPPL2(4), CYP3A4(2), CYP3A43(1), CYP3A5(5), PON1(2)	7656106	22	21	22	7	12	2	3	4	1	0	0.320	0.957	1.000
227	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	GZMB(2)	4033315	2	2	2	1	0	0	1	0	1	0	0.804	0.959	1.000
228	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(2)	2720959	3	3	3	2	2	0	1	0	0	0	0.871	0.960	1.000
229	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2)	6174722	10	10	9	4	4	2	2	2	0	0	0.526	0.960	1.000
230	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB1(1), DUSP10(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAPK1(2), MAPK13(1), MAPKAPK2(1), NFKB1(1), NR2C2(1), SRF(1)	14238525	24	22	24	4	6	8	5	2	3	0	0.0558	0.960	1.000
231	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(2), ATG5(1), IFNA10(2), IFNA21(1), IFNG(2), INS(1), ULK1(1), ULK2(2)	8971557	12	11	12	3	1	2	2	3	4	0	0.385	0.961	1.000
232	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), STAT6(1)	6346422	17	17	17	5	6	2	1	4	4	0	0.459	0.962	1.000
233	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CDK7(1), SHH(2)	3706422	3	2	3	0	2	1	0	0	0	0	0.306	0.963	1.000
234	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CCL2(1), CCR5(1), FOS(1), PLCG1(6), PRKCA(1), PTK2B(3), SYT1(1)	5838350	15	14	15	5	5	1	2	4	3	0	0.451	0.965	1.000
235	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(3), GNB1(1), PRKAG2(1), PRKAR1B(1), PRKAR2B(1)	6542846	7	7	7	0	3	1	0	3	0	0	0.130	0.967	1.000
236	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(1)	2979972	9	9	9	5	5	1	1	0	2	0	0.681	0.968	1.000
237	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNB1(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1)	4100404	4	4	4	1	2	0	0	2	0	0	0.658	0.969	1.000
238	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), GCNT2(1), ST8SIA1(1)	2618535	3	3	3	2	2	0	0	0	1	0	0.880	0.969	1.000
239	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), STX5(1), STX6(1), STX7(1), TSNARE1(2), USE1(1), VAMP3(1), VAMP5(1), VAMP7(3)	7154300	12	12	12	3	3	0	3	4	2	0	0.509	0.969	1.000
240	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGB2(5), PTPRC(2)	4552140	14	14	14	9	7	0	1	3	3	0	0.867	0.970	1.000
241	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(1), SUCLA2(1)	3405262	2	2	2	0	0	1	0	1	0	0	0.529	0.971	1.000
242	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), GH1(1), IGF1(2), IGF1R(3)	4051391	7	7	7	3	0	2	1	3	1	0	0.707	0.972	1.000
243	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3)	5783099	7	7	7	2	2	1	1	1	2	0	0.600	0.973	1.000
244	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C8B(4), C9(2)	8921312	21	21	21	6	7	4	1	5	4	0	0.323	0.973	1.000
245	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	LDLR(3), SCAP(1), SREBF1(1), SREBF2(1)	5130085	6	6	6	2	1	2	0	3	0	0	0.591	0.974	1.000
246	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD28(1), CD3E(2), CD3G(1), CD4(1), ICAM1(1), ITGB2(5), PTPRC(2)	4780462	14	14	14	9	7	0	1	3	3	0	0.873	0.974	1.000
247	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3), NRG1(2)	3235423	5	5	5	4	0	0	0	4	1	0	0.964	0.974	1.000
248	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1)	5409794	6	6	6	2	1	0	2	3	0	0	0.630	0.975	1.000
249	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(3), PDHA1(1), PDHA2(3)	4257939	7	7	7	3	2	3	0	1	1	0	0.687	0.976	1.000
250	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	OXCT2(1)	3066460	1	1	1	1	1	0	0	0	0	0	0.906	0.976	1.000
251	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(3), SRC(2)	12127234	16	15	16	1	6	1	1	7	1	0	0.0569	0.976	1.000
252	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	GFPT1(1), GNPDA1(1), HK2(2), HK3(2), RENBP(1)	7186008	7	7	7	1	4	0	1	1	1	0	0.373	0.978	1.000
253	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(5), GZMB(2)	4506411	7	7	7	3	1	1	2	0	3	0	0.683	0.978	1.000
254	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), GZMB(2), LMNB2(1)	8227520	9	9	9	2	1	1	3	2	2	0	0.390	0.978	1.000
255	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST13(1), SULT2B1(1), SUOX(1)	3915718	3	3	3	0	1	1	0	1	0	0	0.348	0.979	1.000
256	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	5	ABCB11(2), ABCB4(6), ABCC1(1), ABCC3(1)	4973700	10	10	10	7	2	3	1	1	3	0	0.813	0.979	1.000
257	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2)	14090013	20	19	20	3	3	4	7	6	0	0	0.0819	0.979	1.000
258	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6399853	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
259	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6399853	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
260	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6399853	11	11	11	4	4	2	1	4	0	0	0.582	0.979	1.000
261	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(3), CALM1(1), CREB1(1), ELK1(2), FOS(1), GNB1(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1), SYT1(1)	14899891	28	27	28	5	9	4	3	7	5	0	0.0766	0.980	1.000
262	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(1), DLD(2), IDH3A(1), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2)	8368888	12	12	12	3	2	4	0	6	0	0	0.380	0.980	1.000
263	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1)	5256923	8	7	8	3	2	2	0	3	1	0	0.686	0.981	1.000
264	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	20	CCR3(1), GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1)	9647124	11	11	11	2	3	3	2	1	2	0	0.306	0.981	1.000
265	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1)	5668393	6	6	6	2	1	0	2	3	0	0	0.629	0.982	1.000
266	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(1), DDX20(1), E2F4(1), ETS1(2), FOS(1), HDAC2(3), NCOR2(2), RBL1(2), SIN3A(3)	11176943	16	15	16	2	3	3	2	5	3	0	0.168	0.982	1.000
267	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK2(1), IRAK3(3), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1)	12629530	31	29	29	8	7	10	3	6	5	0	0.119	0.982	1.000
268	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	SUOX(1)	2575664	1	1	1	0	0	0	0	1	0	0	0.837	0.982	1.000
269	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), DARS(1), EPRS(2), HARS(2), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1)	13586452	18	18	18	3	3	3	3	7	2	0	0.273	0.983	1.000
270	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2)	3968502	12	12	12	5	5	3	0	2	2	0	0.680	0.983	1.000
271	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2)	3968502	12	12	12	5	5	3	0	2	2	0	0.680	0.983	1.000
272	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), CASP1(2), GAPDH(1), INS(1), INSR(2), ITCH(1), MAGI1(2), MAGI2(2), RERE(6), WWP2(1)	10203599	21	19	21	5	3	6	2	6	4	0	0.346	0.983	1.000
273	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CHUK(1), EGR2(2), EGR3(1), MAP3K1(6), MYC(1), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), SYT1(1), VIPR2(1)	11882184	27	24	25	7	6	6	4	6	5	0	0.170	0.983	1.000
274	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	PRKCA(1), PSEN1(1)	3810158	2	2	2	0	1	0	0	1	0	0	0.567	0.984	1.000
275	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(1), C6(1), C8A(2), C9(2)	5378702	12	12	12	6	3	1	1	4	3	0	0.839	0.984	1.000
276	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	SUCLA2(1)	3060508	1	1	1	0	0	1	0	0	0	0	0.633	0.984	1.000
277	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1), SYT1(1)	4945513	7	7	7	4	2	0	1	1	3	0	0.883	0.984	1.000
278	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(1), AXIN1(3), BMP2(1), BMP4(1), BMP5(4), BMPR2(1), CHRD(2), DVL1(1), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(3), NPPA(2), RFC1(1), TGFBR1(2), TGFBR2(2), TGFBR3(1), WNT1(1)	15539058	30	26	30	5	6	6	5	9	4	0	0.0594	0.985	1.000
279	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(1), NCL(1)	3791724	4	4	4	2	2	0	1	0	1	0	0.795	0.985	1.000
280	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	DPYD(2), DPYS(1), ENPP1(1)	5926460	4	4	4	1	0	0	0	4	0	0	0.741	0.986	1.000
281	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(2), APC(1), AXIN1(3), AXIN2(1), DACT1(1), DKK1(1), DKK2(3), DVL1(1), FSTL1(1), GSK3B(1), LRP1(9), MVP(3), NKD1(1), PSEN1(1), PTPRA(3), WIF1(1)	17279100	34	31	34	6	13	3	5	8	5	0	0.0561	0.986	1.000
282	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(1), CBR1(2), CYP4F2(3), CYP4F3(2), EPX(2), GGT1(1), MPO(2), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4)	11878641	27	26	27	6	16	2	0	6	3	0	0.112	0.987	1.000
283	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	6426199	11	10	11	3	5	2	0	2	2	0	0.289	0.987	1.000
284	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(2), ATM(4), BRCA1(4), CDKN1A(1), CHEK1(3), CHEK2(4), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1)	12322813	25	25	23	6	7	2	6	6	4	0	0.342	0.988	1.000
285	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1)	6811928	11	11	11	4	4	2	1	4	0	0	0.585	0.988	1.000
286	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(4), AGXT(1), AKR1B10(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(2), SARDH(1), SARS2(1), TARS(1), TARS2(1)	18091150	37	36	37	7	14	7	1	12	3	0	0.0611	0.990	1.000
287	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1)	5782774	5	5	5	2	0	0	1	2	2	0	0.928	0.990	1.000
288	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ARPC2(1)	3446428	1	1	1	1	0	0	0	0	1	0	1.000	0.991	1.000
289	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), SYT1(1), YWHAH(1)	8655592	11	11	11	3	2	2	2	3	2	0	0.412	0.991	1.000
290	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	26	CASP10(1), DAXX(3), FAF1(1), LMNB2(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(4), PTPN13(1), SPTAN1(3)	16943189	24	23	22	4	3	9	4	3	5	0	0.0641	0.991	1.000
291	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	10	CBL(1), CSF1R(1), EGF(3), MET(3), PRKCA(1), SRC(2)	6162790	11	8	11	4	2	1	1	6	1	0	0.770	0.991	1.000
292	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(1), GAD1(1), HDC(3), TPH1(2)	2586206	7	7	7	4	4	1	0	2	0	0	0.744	0.991	1.000
293	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), F10(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(1)	19031781	57	51	57	15	12	15	8	14	8	0	0.0881	0.991	1.000
294	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), CYP2A13(1), XDH(3)	3376477	6	6	6	5	2	2	0	1	1	0	0.884	0.992	1.000
295	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1)	9956570	8	8	8	1	2	3	2	0	1	0	0.186	0.992	1.000
296	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1)	13697360	32	29	30	8	9	8	6	7	2	0	0.120	0.992	1.000
297	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(1), ACO1(1), SUCLA2(1)	5266553	3	3	3	0	0	1	0	1	1	0	0.428	0.992	1.000
298	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1)	4715398	11	11	11	6	3	3	0	3	2	0	0.838	0.993	1.000
299	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), DHCR7(1), FDPS(2), IDI2(1), MVD(1), MVK(1), NQO1(1)	8262742	8	8	8	2	2	1	2	2	1	0	0.560	0.993	1.000
300	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	10417684	21	20	19	6	4	9	2	4	2	0	0.256	0.994	1.000
301	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(5), EP300(1), NCOA1(1), NCOA2(3), PPARG(1), RXRA(3)	7845719	14	14	14	5	4	2	1	2	5	0	0.605	0.994	1.000
302	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	62	ATM(4), CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MYC(1), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLE(1), POLE2(1), PRIM1(1), RBL1(2), RPA2(1), TFDP1(1), TNXB(3), WEE1(1)	31730863	57	50	57	9	7	8	8	19	15	0	0.0319	0.994	1.000
303	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ACAA1(1), ACADS(4), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(2), PCCB(1)	18300781	28	27	27	5	13	7	4	2	2	0	0.0319	0.994	1.000
304	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	NCOA1(1), NCOA2(3), NCOR2(2), POLR2A(2), RXRA(3), TBP(2)	10677473	13	13	13	3	2	2	0	3	6	0	0.443	0.994	1.000
305	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), MAPK1(2), MAPK3(1), PTK2B(3), SOS1(3)	7394467	10	10	10	3	3	2	2	2	1	0	0.482	0.994	1.000
306	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	11	CREBBP(5), DAXX(3), PAX3(3), SP100(2), TNFRSF1A(1), TNFRSF1B(1)	7062626	15	15	15	5	3	3	2	4	3	0	0.548	0.995	1.000
307	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM1(1), CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), SP1(1), SP3(1), SYT1(1)	8895994	17	16	17	5	4	4	2	4	3	0	0.308	0.995	1.000
308	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), DDC(3), EPX(2), ESCO1(1), GOT2(1), MAOA(1), MAOB(2), MPO(2), MYST4(1), TAT(2), TPO(4)	14553304	29	26	28	5	17	4	1	6	1	0	0.0318	0.995	1.000
309	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IFNG(2), IL12B(2), IL16(1), IL1A(1), IL3(1), IL6(1)	4196550	9	9	9	5	2	2	1	3	1	0	0.749	0.995	1.000
310	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(5), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9799844	22	22	22	6	10	3	2	4	3	0	0.304	0.996	1.000
311	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(5), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3)	9799844	22	22	22	6	10	3	2	4	3	0	0.304	0.996	1.000
312	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(5), EP300(1), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(3), NFKB1(1), NFKBIA(1), TGFBR1(2), TGFBR2(2), TLR2(4)	12618706	25	23	25	6	6	7	3	3	6	0	0.147	0.996	1.000
313	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(2), RECK(1), TIMP3(1)	3193896	4	4	4	3	2	0	0	2	0	0	0.877	0.996	1.000
314	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(3), CASP1(2), CASP10(1), CASP9(1), GZMB(2)	5462603	9	9	8	5	1	1	1	4	2	0	0.861	0.996	1.000
315	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(1)	5187339	8	8	8	4	1	2	0	3	2	0	0.743	0.996	1.000
316	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(3), PDHA1(1), PDHA2(3), VARS(1), VARS2(2)	7923155	10	10	10	3	2	3	2	2	1	0	0.461	0.996	1.000
317	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), PSEN1(1)	4033736	2	2	2	1	0	0	0	1	1	0	0.931	0.996	1.000
318	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(4), ACY3(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), CARM1(3), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), PRMT8(1), PRPS2(2), UROC1(1)	16900789	36	32	35	6	20	4	1	10	1	0	0.0159	0.997	1.000
319	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	29	AKT1(1), ANGPTL2(1), DAG1(2), DGKA(1), GCA(1), ITGA9(2), ITPR1(5), ITPR2(3), ITPR3(5), MAP2K1(1), MAPK1(2), MAPK3(1), NR1I3(2), PAK1(1), PDE3A(3), PDE3B(3), RIPK3(1), RPS4X(1), VASP(1)	18141564	37	35	37	9	12	12	3	3	7	0	0.0496	0.997	1.000
320	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	16	CTH(1), GOT2(1), LDHAL6A(1), LDHAL6B(1)	5055934	4	4	4	2	0	1	0	3	0	0	0.878	0.997	1.000
321	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(1), GALNT6(1), GALNT7(1), GALNT9(2), GCNT1(2), ST3GAL1(1), WBSCR17(7)	6108802	16	16	16	7	6	3	1	3	3	0	0.743	0.997	1.000
322	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), CYP11A1(3), HPGD(1), HSD11B1(2), PLA2G4A(3), PTGER4(1), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	8779969	17	17	17	5	7	2	0	4	4	0	0.344	0.997	1.000
323	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	AKT1(1), ATM(4), CDKN1A(1), CSNK1D(1), MDM2(2), NQO1(1)	7396547	10	10	10	4	1	3	2	0	4	0	0.755	0.997	1.000
324	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(4), CALM1(1), EPS15(2), PICALM(1), PPP3CB(1), SYNJ2(3), SYT1(1)	9267389	13	13	13	4	7	0	2	2	2	0	0.366	0.997	1.000
325	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(2), IL1A(1), IL3(1), IL6(1), IL7(1)	5671762	13	13	13	6	4	3	2	2	2	0	0.622	0.997	1.000
326	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), SOS1(3), SRC(2), ZYX(2)	20099087	28	23	28	3	7	5	6	7	3	0	0.0174	0.997	1.000
327	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(2), ACADS(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), PDHA1(1), PDHA2(3)	10954598	21	21	21	7	9	6	1	2	3	0	0.288	0.997	1.000
328	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN3(1), CSK(1), CTNNA1(2), CTNNA2(2), PXN(1), SRC(2)	8156079	11	10	11	3	2	3	1	4	1	0	0.495	0.997	1.000
329	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2)	7526996	17	17	17	6	6	2	1	5	3	0	0.576	0.997	1.000
330	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	32	AKT1(1), ASAH1(1), DAG1(2), DRD2(1), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CB(4), PITX2(3), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1), TERF2IP(1)	23258843	46	41	46	8	14	14	6	7	5	0	0.00716	0.997	1.000
331	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	12	AKT1(1), BCL2(2), IGF1R(3), MYC(1), POLR2A(2), PRKCA(1), TEP1(4), TERT(3), TNKS(1), XRCC5(1)	9777465	19	19	19	6	4	4	2	3	6	0	0.543	0.998	1.000
332	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), ST6GAL1(1)	8442453	10	10	10	3	4	1	0	3	2	0	0.431	0.998	1.000
333	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(4), ATR(4), BRCA1(4), BRCA2(4), CHEK1(3), CHEK2(4), FANCD2(2), MRE11A(1), RAD50(1)	18363009	27	27	25	5	5	4	9	7	2	0	0.119	0.998	1.000
334	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(1), CALM1(1), CAMK2A(1), F2(1), FYN(1), GNB1(1), JAK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), STAT1(2), STAT3(1), SYT1(1)	17757280	33	29	33	7	7	3	6	11	6	0	0.108	0.998	1.000
335	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	BCL2(2), CREBBP(5), EP300(1), FYN(1), IL7(1), IL7R(2), JAK1(2), JAK3(2), PTK2B(3), STAT5B(1)	10349725	20	20	20	9	5	4	2	2	7	0	0.808	0.998	1.000
336	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ARPC2(1), NCKAP1(1), NTRK1(1), WASF3(1)	6482448	4	4	4	5	0	0	1	0	3	0	0.994	0.998	1.000
337	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), SOS1(3)	6042203	9	9	9	4	1	3	1	2	2	0	0.632	0.998	1.000
338	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	LCT(3), PGM1(1), PYGL(1), PYGM(1), TREH(1)	5704517	7	7	7	3	3	2	1	1	0	0	0.588	0.998	1.000
339	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	IMPDH1(2), POLD1(1), PRPS2(2)	5369314	5	5	5	2	4	0	0	1	0	0	0.680	0.998	1.000
340	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(1), PSMA5(1), PSMC3(1)	6771467	3	3	3	1	0	1	1	0	1	0	0.747	0.998	1.000
341	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR2(1), DNMT1(1), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(1)	4810181	6	6	6	9	3	0	0	1	2	0	0.996	0.998	1.000
342	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	EGF(3), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1)	13202389	31	29	29	9	5	8	4	10	4	0	0.349	0.999	1.000
343	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(1), PSMA5(1), PSMC3(1), UBE3A(1)	5484648	4	4	4	2	0	1	2	0	1	0	0.810	0.999	1.000
344	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(3), MAP2K1(1), MAP3K1(6), NCOR2(2), RXRA(3), THRA(1)	6262997	16	16	14	7	3	5	1	4	3	0	0.790	0.999	1.000
345	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	ELK1(2), FOS(1), INS(1), INSR(2), IRS1(4), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1)	9249301	21	20	21	7	4	4	3	7	3	0	0.545	0.999	1.000
346	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(3), CYP27A1(1), CYP7A1(1), SRD5A1(1), SRD5A2(1)	9900631	22	21	22	8	8	5	1	7	1	0	0.497	0.999	1.000
347	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(2), JAK1(2), JAK2(2), JAK3(2), STAT1(2), STAT3(1), STAT5B(1), TYK2(3)	7886078	15	15	15	5	6	1	0	5	3	0	0.560	0.999	1.000
348	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	ADAM12(1), AGT(1), AGTR2(1), EGF(3), FOS(1), MYC(1), NFKB1(1), PLCG1(6), PRKCA(1)	7576965	16	14	16	6	4	1	2	7	2	0	0.713	0.999	1.000
349	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(4), AOC2(2), CES1(2), ESCO1(1), MYST4(1), PLA1A(1), PPME1(1)	10789490	13	13	13	4	7	3	0	3	0	0	0.400	0.999	1.000
350	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), BCL2(2), GSK3B(1), IL4R(7), IRS1(4), IRS2(1), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(2), MAPK3(1), RAF1(1), SOCS1(1), SOS1(3), STAT6(1)	14017071	31	31	31	9	9	3	4	8	7	0	0.456	0.999	1.000
351	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), CHAT(2), DBH(1), DDC(3), GAD1(1), HDC(3), MAOA(1), PAH(2), SLC18A3(1), TPH1(2)	6149632	17	16	17	7	10	1	2	4	0	0	0.493	0.999	1.000
352	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), REN(5)	10871720	30	27	29	10	9	9	4	4	4	0	0.325	0.999	1.000
353	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(3), CREB1(1), CREBBP(5), EP300(1), PRKAR1B(1), PRKAR2B(1), RXRA(3)	8789558	15	15	14	5	4	4	1	2	4	0	0.516	0.999	1.000
354	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CARM1(3), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), METTL6(1), PRMT8(1), SCLY(1)	10615379	15	14	14	4	5	4	0	4	2	0	0.361	0.999	1.000
355	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1)	10214287	6	6	6	1	2	1	1	1	1	0	0.458	0.999	1.000
356	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR2(4), HLA-DRA(1), ICAM1(1), ITGB2(5), PTPRC(2)	6474045	13	12	13	9	7	1	0	3	2	0	0.909	0.999	1.000
357	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), PSEN1(1), WNT1(1)	9219499	11	10	11	4	1	1	1	5	3	0	0.767	0.999	1.000
358	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(2), MRPL13(1), RPL10L(2), RPL11(2), RPL13A(1), RPL22L1(1), RPL36A(2), RPL3L(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1)	9721608	16	15	16	6	4	1	2	2	7	0	0.874	0.999	1.000
359	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	DIAPH2(3), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), PRIM1(1), RFC1(1), RFC4(1), RPA2(1), RPA4(2), UBA52(2), UBC(2)	21685413	33	33	33	6	7	7	4	11	4	0	0.0827	0.999	1.000
360	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1)	5203117	7	6	7	5	4	0	0	1	2	0	0.743	0.999	1.000
361	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), TSC2(3)	9843004	8	8	8	2	2	2	0	4	0	0	0.519	0.999	1.000
362	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(5), EP300(1), ESR1(1), MAPK1(2), MAPK3(1), SRC(2)	6262097	12	12	12	5	2	4	2	2	2	0	0.626	1.000	1.000
363	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(1), AKT1(1), BTK(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(2), YWHAH(1)	14024992	24	23	24	6	5	8	2	6	3	0	0.190	1.000	1.000
364	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), MTA1(1), MTA3(1), TUBA8(1)	4716140	4	4	4	5	2	0	0	1	1	0	0.949	1.000	1.000
365	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), AGXT(1), ASNS(2), CAD(3), CRAT(1), DARS(1), GAD1(1), GOT2(1), PC(2)	11072827	13	13	13	4	0	3	3	4	3	0	0.611	1.000	1.000
366	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	DLD(2), IDH3A(1), PC(2), PDHA1(1), PDHA2(3), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2)	11162068	14	13	14	4	3	6	0	4	1	0	0.357	1.000	1.000
367	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOX1(4), DBH(1), DCT(1), DDC(3), GOT2(1), MAOA(1), MAOB(2), TAT(2), TPO(4), TYR(1)	13500254	36	33	34	10	22	3	2	9	0	0	0.105	1.000	1.000
368	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(4), CRY1(1), CSNK1D(1), PER1(1), PER2(3), PER3(2)	7293507	12	12	11	5	4	4	0	1	3	0	0.744	1.000	1.000
369	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	EIF2B1(1), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PLCG1(6), PRKCA(1), PXN(1)	12943369	31	28	31	9	11	6	3	7	4	0	0.214	1.000	1.000
370	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2), MASP2(1), MBL2(1)	9148335	19	19	19	7	6	3	1	6	3	0	0.566	1.000	1.000
371	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1)	7009089	11	11	11	8	4	2	1	2	2	0	0.925	1.000	1.000
372	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), AKR1B10(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CEL(3), CYP27A1(1), CYP7A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1)	13545307	25	23	25	8	7	6	1	9	2	0	0.452	1.000	1.000
373	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(3), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1)	6402718	7	7	6	3	3	2	0	1	1	0	0.637	1.000	1.000
374	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(2), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), MLYCD(1)	12340731	22	21	22	7	10	5	0	6	1	0	0.277	1.000	1.000
375	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(4), MAPK1(2), MAPK3(1), PRKCA(1)	10009178	12	11	12	4	3	2	2	3	2	0	0.626	1.000	1.000
376	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(1), ASAH1(1), CREB1(1), DAG1(2), EPHB2(3), FOS(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3)	12151575	18	18	18	5	5	3	6	1	3	0	0.373	1.000	1.000
377	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	27	CRADD(1), LMNB2(1), MADD(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(4), RIPK1(1), SPTAN1(3), TNFRSF1A(1)	16001281	22	21	20	5	4	7	3	4	4	0	0.168	1.000	1.000
378	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), GZMB(2), MAP3K1(6), MCL1(1), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), PARP1(2), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(2), TRAF1(1)	15608847	27	27	25	8	6	5	4	6	6	0	0.362	1.000	1.000
379	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), NFKB1(1)	6209163	2	2	2	2	1	0	0	0	1	0	0.888	1.000	1.000
380	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PRKAR1B(1), PRKAR2B(1)	6817871	11	11	11	5	6	1	0	2	2	0	0.762	1.000	1.000
381	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	CREB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3)	11978013	13	13	13	4	4	2	2	3	2	0	0.546	1.000	1.000
382	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	29	ABP1(4), ADC(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(2), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(2), NAGS(1)	12279590	25	25	25	8	10	2	3	9	1	0	0.481	1.000	1.000
383	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(1), POLE(1), POLL(1), POLQ(3)	7105957	6	6	6	3	2	0	0	3	1	0	0.918	1.000	1.000
384	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	AMT(2), MTHFD1(1), MTHFR(1)	7601920	4	4	4	2	1	0	2	0	1	0	0.802	1.000	1.000
385	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PXN(1), RAF1(1), ROCK1(2), SRC(2)	14295959	20	18	19	5	4	2	3	7	4	0	0.396	1.000	1.000
386	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	FUCA1(4), HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2), SPAM1(4)	14776567	30	28	29	9	11	6	1	10	2	0	0.248	1.000	1.000
387	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), WNT1(1)	11543219	17	16	17	5	5	4	3	3	2	0	0.409	1.000	1.000
388	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(3), GNB1(1), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2)	8792612	11	11	10	6	2	1	0	5	3	0	0.910	1.000	1.000
389	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(1), CETP(2), CYP7A1(1), DGAT1(2), LCAT(1), LDLR(3), LRP1(9), SCARB1(1), SOAT1(3)	11638665	23	22	23	8	5	3	2	6	7	0	0.573	1.000	1.000
390	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	DPYD(2), DPYS(1), ENPP1(1)	7355325	4	4	4	2	0	0	0	4	0	0	0.875	1.000	1.000
391	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	36	ABP1(4), AGXT(1), ALAS1(1), AMT(2), AOC2(2), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(3), SARDH(1), TARS(1)	17770218	42	37	42	10	15	7	2	14	4	0	0.112	1.000	1.000
392	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACOT11(1), ACYP1(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), ITGB1BP3(1), MYST4(1), YOD1(1)	11027242	9	9	9	3	3	5	0	0	1	0	0.433	1.000	1.000
393	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(4), JAK1(2), JAK3(2), MAPK1(2), MAPK3(1), MYC(1), PTPN6(1), RAF1(1), SOCS1(1), SOS1(3), STAT5B(1)	13824634	25	25	25	8	6	2	4	6	7	0	0.708	1.000	1.000
394	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	AMT(2), MTHFD1(1), MTHFR(1)	8061615	4	4	4	2	1	0	2	0	1	0	0.803	1.000	1.000
395	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(4), ATR(4), BRCA1(4), CDKN1A(1), CHEK1(3), CHEK2(4), EP300(1), MDM2(2), PRKDC(4), RPS6KA1(1), WEE1(1), YWHAH(1)	17679323	30	30	28	8	6	7	7	5	5	0	0.260	1.000	1.000
396	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	CHUK(1), IFNG(2), IKBKB(1), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3)	8277615	17	15	14	8	5	5	3	2	2	0	0.622	1.000	1.000
397	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2)	7421086	7	7	7	6	2	1	0	2	2	0	0.980	1.000	1.000
398	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLI(2), POLL(1), POLQ(3), PRIM1(1), PRIM2(1), REV1(2), REV3L(1)	17420081	17	17	17	4	5	2	1	7	2	0	0.488	1.000	1.000
399	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1A3(1), ALDH3A1(2), CYP2C19(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), MYST4(1), YOD1(1)	13137748	11	10	11	3	5	4	0	1	1	0	0.292	1.000	1.000
400	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(1), CREBBP(5), EP300(1), MAP2K1(1), MAP3K7(3), MAPK3(1), TGFBR1(2), TGFBR2(2)	10877230	16	16	16	6	2	5	4	1	4	0	0.567	1.000	1.000
401	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BCL2(2), BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(3), TNFRSF25(1), TNFSF10(2)	14276736	16	15	16	4	4	0	2	6	4	0	0.491	1.000	1.000
402	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ELOVL2(1), HADHA(1)	6166667	3	3	3	2	1	2	0	0	0	0	0.672	1.000	1.000
403	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), ESCO1(1), MYST4(1)	10617885	10	9	10	4	2	3	0	5	0	0	0.685	1.000	1.000
404	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(4), TLR3(1), TLR6(5), TLR7(4), TLR9(2)	15573783	42	40	40	12	14	11	4	8	5	0	0.166	1.000	1.000
405	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	42	ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(2), CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT2(1), MAOA(1), MAOB(2), NOS1(6), NOS3(3), P4HB(1), RARS(1)	18624615	46	42	45	12	26	6	4	10	0	0	0.0747	1.000	1.000
406	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(5), EP300(1), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	9537925	13	12	13	5	3	3	1	3	3	0	0.592	1.000	1.000
407	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ACACA(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2)	14028566	23	22	23	7	9	6	2	4	2	0	0.351	1.000	1.000
408	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), BTK(1), GSK3B(1), LYN(2), PFKL(1), PLCG1(6), PRKCE(1), VAV2(2)	10701992	15	14	15	5	3	5	3	3	1	0	0.368	1.000	1.000
409	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	CREB1(1), EP300(1), EPO(1), NOS3(3), P4HB(1)	7292594	7	7	7	5	4	1	0	1	1	0	0.910	1.000	1.000
410	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CSK(1), DAG1(2), DTYMK(1), EPHB2(3), FBXW7(1), GRAP2(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PLCG1(6), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP2(2), RASGRP4(1), SOS1(3), VAV1(4), ZAP70(3)	23896489	49	45	49	10	13	8	7	12	9	0	0.0815	1.000	1.000
411	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	30	AKT1(1), APC(1), ASAH1(1), CCL13(1), DAG1(2), GNA15(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RAF1(1), SRC(2)	19504563	31	30	31	8	10	10	5	3	3	0	0.0716	1.000	1.000
412	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	38	ANAPC1(2), ANAPC4(2), ANAPC7(1), BTRC(1), CDC23(2), CUL1(3), CUL2(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(1), SKP2(1), SMURF1(2), UBE2E3(1), WWP2(1)	16495326	21	21	21	5	4	2	4	6	5	0	0.384	1.000	1.000
413	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1)	20626882	41	39	41	11	16	8	0	12	5	0	0.143	1.000	1.000
414	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CALM1(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4), ZAP70(3)	18742835	42	38	40	11	12	7	8	9	6	0	0.123	1.000	1.000
415	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(1), AXIN1(3), BTRC(1), CREBBP(5), CSNK1D(1), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(3), MYC(1), WIF1(1), WNT1(1)	12553660	20	19	20	9	2	4	3	5	6	0	0.835	1.000	1.000
416	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ADC(2), ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUD2(3), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2)	16786049	25	24	25	6	5	4	7	8	1	0	0.246	1.000	1.000
417	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1)	6983981	9	9	9	8	3	2	0	3	1	0	0.963	1.000	1.000
418	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), ATP7A(3), COX10(2), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1)	16248082	22	22	22	6	6	5	2	8	1	0	0.285	1.000	1.000
419	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CHUK(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(6), MAP4K2(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1)	10334529	17	15	15	9	5	5	1	3	3	0	0.788	1.000	1.000
420	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), RAF1(1), SOS1(3), STAT5B(1)	10029991	14	14	14	7	4	1	2	4	3	0	0.910	1.000	1.000
421	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC23A2(1), SLC2A1(2), SLC2A3(2)	10827827	26	23	26	10	7	7	4	4	4	0	0.421	1.000	1.000
422	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1B(1), TRAF1(1)	9558723	15	14	13	6	4	5	1	4	1	0	0.529	1.000	1.000
423	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AMD1(2), CBS(1), CTH(1), DNMT1(1), MARS(2), MAT1A(2), TAT(2)	8827527	11	11	10	6	5	2	0	2	2	0	0.848	1.000	1.000
424	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), CALM1(1), ELK1(2), FCER1A(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFATC2(2), NFATC4(2), PLA2G4A(3), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4)	16699361	42	36	40	12	8	12	8	9	5	0	0.146	1.000	1.000
425	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	CP(4), EPRS(2), FECH(1), HCCS(1), HMBS(1), HMOX1(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1)	11165643	20	19	20	7	6	2	3	7	2	0	0.508	1.000	1.000
426	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), DLG4(3), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), NOS1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(1)	10898738	31	29	31	11	22	1	2	5	1	0	0.289	1.000	1.000
427	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM1(1), CAPNS1(1), EP300(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1), SYT1(1)	10342087	17	17	17	7	5	3	3	3	3	0	0.578	1.000	1.000
428	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	BCL2(2), CHUK(1), DAXX(3), EGF(3), ETS1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), RAF1(1), RIPK1(1), SP1(1), TNFRSF1A(1), TNFRSF1B(1)	19792665	44	41	41	12	12	9	7	9	7	0	0.198	1.000	1.000
429	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT2(1), EXTL1(1), HS3ST1(2), HS3ST3A1(2), NDST3(1), NDST4(6)	8844888	13	12	13	5	5	1	5	2	0	0	0.559	1.000	1.000
430	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), BIRC3(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1)	11604415	17	16	17	6	2	4	4	5	2	0	0.574	1.000	1.000
431	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACADS(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), HADHA(1), MCCC1(1), MUT(1), PCCA(2), PCCB(1)	15276879	25	24	24	9	13	5	4	2	1	0	0.314	1.000	1.000
432	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	33	ASS1(1), CKB(1), CKM(1), CKMT1A(2), CKMT1B(2), CPS1(5), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(3), GOT2(1), NOS1(6), NOS3(3), PARS2(1), PRODH(1), RARS(1)	15072138	36	34	35	10	21	3	5	7	0	0	0.179	1.000	1.000
433	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPN1(2), CAPNS1(1), EGF(3), ITGA1(2), ITGB1(1), MAPK1(2), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1)	12837107	17	17	17	6	5	1	2	8	1	0	0.617	1.000	1.000
434	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AGPAT6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), CEL(3), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK2(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1)	25093263	42	41	42	10	16	7	0	13	6	0	0.0985	1.000	1.000
435	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(2), BDKRB1(1), C1QC(1), C1S(3), C2(2), C3(6), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(2), C8B(4), C9(2), CD46(2), CD55(1), CD59(1), CFB(1), CFH(2), CFI(1), CR2(4), F10(1), F13A1(3), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), KNG1(2), MASP2(1), MBL2(1), PLAT(3), PLG(2), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(1), SERPINE1(2), SERPING1(1), VWF(7)	38603215	104	83	104	28	32	21	11	25	15	0	0.0287	1.000	1.000
436	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(3), F2(1), F2RL3(2), MAPK1(2), MAPK7(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(4)	11713207	23	22	23	8	8	5	3	5	2	0	0.419	1.000	1.000
437	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOX1(4), CARM1(3), DBH(1), DCT(1), DDC(3), ESCO1(1), GOT2(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), MYST4(1), PRMT8(1), TAT(2), TPO(4), TYR(1), TYRP1(2)	25323263	47	43	43	11	25	7	2	10	3	0	0.0463	1.000	1.000
438	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2(2), BCL2A1(1), BOK(1), CASP1(2), CASP10(1), CASP9(1), CRADD(1), DAXX(3), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), SFRS2IP(4), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	18685366	25	23	24	9	5	4	1	7	8	0	0.726	1.000	1.000
439	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPT(2), ALPI(1), ALPP(3), ALPPL2(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), PON1(2)	12436380	45	42	44	15	25	3	7	7	3	0	0.257	1.000	1.000
440	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	19	MAP3K1(6), MYLK(2), NCF2(2), PAK1(1), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(2), VAV1(4)	12313945	20	19	18	8	3	5	4	5	3	0	0.605	1.000	1.000
441	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	MAPK1(2), MAPK13(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), SYT1(1)	12732357	19	19	19	8	5	4	4	2	4	0	0.707	1.000	1.000
442	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(4), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), NCKAP1(1), PER1(1), PER2(3), PIGF(1), SF3A3(1), ZFR(2)	15588634	18	17	17	6	7	2	2	2	5	0	0.615	1.000	1.000
443	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(2), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(1), VARS2(2), WARS(1), YARS2(1)	23078027	27	27	27	6	4	4	5	10	4	0	0.368	1.000	1.000
444	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG2(2), ADCY3(3), ADCY9(4), AK1(1), ARL4D(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), PLCG1(6), PLCG2(3), PRKCA(1), TRIM23(1)	15729483	33	31	33	10	11	7	3	8	4	0	0.293	1.000	1.000
445	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	ERBB2(1), ETS1(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(2), PIWIL3(2), PIWIL4(1), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1)	20599532	30	28	29	9	8	7	6	5	4	0	0.339	1.000	1.000
446	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	AKT1(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PITX2(3), PLD1(1)	19182003	31	27	31	9	8	11	3	5	4	0	0.146	1.000	1.000
447	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CYB5R1(1), GFPT1(1), GNPDA1(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), NPL(1), RENBP(1)	12184271	13	13	13	5	7	0	3	2	1	0	0.667	1.000	1.000
448	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ACY3(1), AGXT(1), ASNS(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DLD(2), GAD1(1), GOT2(1), PC(2), PDHA1(1), PDHA2(3)	16104224	22	22	22	9	4	6	3	4	5	0	0.718	1.000	1.000
449	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), PFKFB1(2), PFKFB4(1), PMM1(1)	10201544	12	11	12	9	7	1	1	2	1	0	0.909	1.000	1.000
450	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	41	AKT1(1), EIF4B(1), FIGF(2), IGF1(2), INS(1), MAPK1(2), MAPK3(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(3), ULK1(1), ULK2(2), VEGFA(2), VEGFB(1), VEGFC(1)	20563540	46	40	46	13	15	10	5	12	4	0	0.186	1.000	1.000
451	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	57	AANAT(1), ABP1(4), ACMSD(1), ALDH1A3(1), ALDH3A1(2), AOC2(2), AOX1(4), ASMT(1), CARM1(3), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), NFX1(1), OGDHL(3), PRMT8(1), TPH1(2), WARS(1)	24865059	44	41	42	11	21	6	1	12	4	0	0.0980	1.000	1.000
452	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM1(1), ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4)	16260863	36	32	34	12	8	9	7	7	5	0	0.290	1.000	1.000
453	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), AGTR2(1), ATP8A1(2), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CX3CR1(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(1), LHCGR(2), MC2R(3), MC3R(4), MC4R(3), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), PPYR1(1), SSTR2(1), SSTR3(1), SSTR4(4), TACR3(4), TSHR(1)	22211211	67	65	67	23	42	9	3	11	2	0	0.0678	1.000	1.000
454	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), GTF2H1(2), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2)	14853277	15	14	15	7	2	4	2	4	3	0	0.799	1.000	1.000
455	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), INS(1), INSR(2), IRS1(4), JAK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), PLCG1(6), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SOCS1(1), SOS1(3), SRF(1), STAT5B(1)	12443750	30	28	30	10	7	5	5	8	5	0	0.513	1.000	1.000
456	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	38	ALAS1(1), COX10(2), CP(4), EPRS(2), FECH(1), FTMT(4), HCCS(1), HMBS(1), HMOX1(1), MMAB(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(4), UGT2B10(8), UGT2B11(2), UGT2B15(1), UGT2B7(2)	16592793	44	40	41	14	14	5	7	16	2	0	0.423	1.000	1.000
457	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(4), IRS2(1), IRS4(3), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(1), PPYR1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(2), SOS1(3), YWHAE(2), YWHAH(1)	23287295	38	37	38	10	5	6	6	10	11	0	0.351	1.000	1.000
458	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(4), CARM1(3), CREBBP(5), EP300(1), ESR1(1), GRIP1(7), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(2), NRIP1(2), POLR2A(2), TBP(2)	19805182	34	32	33	10	9	12	2	5	6	0	0.218	1.000	1.000
459	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(2), AOX1(4), ASMT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(4), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), KYNU(1), MAOA(1), MAOB(2), TPH1(2), WARS(1)	23400697	65	54	63	19	36	6	7	13	3	0	0.0873	1.000	1.000
460	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(1), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RYR1(4)	19660407	37	35	37	11	16	11	4	3	3	0	0.0809	1.000	1.000
461	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AGT(1), AKT1(1), CALM1(1), CAMK1(1), CAMK4(1), CREBBP(5), ELSPBP1(3), F2(1), GATA4(2), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(2), MAPK3(1), MYH2(9), NFATC2(2), NFATC4(2), NPPA(2), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1), SYT1(1)	19983553	43	38	43	14	15	4	5	11	8	0	0.325	1.000	1.000
462	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	38	AKT1(1), ASAH1(1), CREB1(1), CREBBP(5), CRKL(1), DAG1(2), EGR1(3), EGR2(2), EGR3(1), ELK1(2), MAP1B(2), MAPK1(2), MAPK3(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NTRK1(1), PTPN11(4), RPS6KA3(1), SRC(2), TERF2IP(1)	18692731	40	38	40	14	9	8	6	8	9	0	0.516	1.000	1.000
463	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	66	ADH1A(2), ADH1B(2), ADH1C(2), AKR1C1(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), CYP1A2(2), CYP1B1(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), EPHX1(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(4), UGT2B10(8), UGT2B11(2), UGT2B15(1), UGT2B7(2)	23012612	67	59	64	21	26	8	7	23	3	0	0.218	1.000	1.000
464	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(1), CAMK1(1), ELK1(2), GNA15(1), GNB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NCF1(1), NCF2(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PLCB1(1), PPP3CB(1), RAF1(1), SYT1(1)	15250432	33	31	31	12	10	8	4	4	7	0	0.423	1.000	1.000
465	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), ESR1(1), ESR2(3), HNF4A(4), NPM1(1), NR1H2(2), NR1I2(1), NR1I3(2), NR2C2(1), NR2F2(2), NR4A1(2), NR5A2(1), PGR(5), PPARA(1), PPARG(1), RARB(1), RORC(3), RXRA(3), THRA(1)	17953939	36	35	36	12	12	5	3	11	5	0	0.522	1.000	1.000
466	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AKAP1(1), AKAP11(1), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), CALM1(1), GNA15(1), GNAO1(1), GNB1(1), GNG5(1), GNGT2(1), ITPR1(5), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1C(4), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKD3(2)	49897435	79	64	77	15	28	18	8	15	10	0	0.00300	1.000	1.000
467	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(1), AXIN1(3), CCND2(2), CCND3(1), DVL1(1), DVL2(4), DVL3(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LDLR(3), MYC(1), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1)	25259832	41	37	39	12	10	6	6	11	8	0	0.350	1.000	1.000
468	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2B1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(2), PABPC3(4)	18717702	17	17	17	9	5	3	1	5	3	0	0.893	1.000	1.000
469	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	51	BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), CHUK(1), CRADD(1), DAXX(3), GSN(1), LMNB2(1), MAP3K1(6), MAP3K5(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(4), PRKCD(3), PRKDC(4), PSEN1(1), RIPK1(1), SPTAN1(3), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1)	28989403	42	39	39	10	10	7	6	10	9	0	0.160	1.000	1.000
470	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACADS(4), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(4), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1)	20808895	30	28	30	10	13	4	2	7	4	0	0.342	1.000	1.000
471	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1L(1), GTF2H1(2), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(9), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(4), TBPL2(1)	15331345	30	27	30	10	8	3	3	12	4	0	0.694	1.000	1.000
472	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(1), CASP9(1), KDR(8), KRAS(2), MAP2K1(1), MAPK1(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFATC2(2), NFATC4(2), NOS3(3), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PXN(1), RAF1(1), SRC(2), VEGFA(2)	29265080	71	60	70	21	23	17	4	18	9	0	0.0732	1.000	1.000
473	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG2(2), AKT1(1), ANGPTL2(1), CFL2(1), FLNA(5), FLNC(3), FSCN2(1), GDI1(1), MYH2(9), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), ROCK1(2), ROCK2(1), RPS4X(1), VASP(1)	20502607	37	34	36	13	21	3	3	4	6	0	0.290	1.000	1.000
474	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	63	ATM(4), ATR(4), CASP9(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), CHEK2(4), DDB2(1), GADD45B(1), GTSE1(1), IGF1(2), LRDD(1), MDM2(2), MDM4(1), PPM1D(1), RPRM(1), RRM2(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN3(1), SFN(1), THBS1(2), TSC2(3)	27128092	51	49	49	15	8	9	10	15	9	0	0.328	1.000	1.000
475	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(5), ACYP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	15714288	27	26	27	10	13	5	0	7	2	0	0.483	1.000	1.000
476	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	92	ANK2(8), CDR1(1), DGKI(2), FAU(2), RPL10(2), RPL11(2), RPL13A(1), RPL15(1), RPL22(1), RPL3L(1), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(2), UBC(2)	22167244	41	38	41	10	11	7	6	9	8	0	0.275	1.000	1.000
477	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(1), ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), MGAT5B(1), ST6GAL1(1)	18093370	13	13	13	9	5	3	0	3	2	0	0.896	1.000	1.000
478	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	AGPAT1(2), AGPAT2(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(1), GNPAT(1), GPD2(1), LCAT(1), MYST4(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1), PTDSS1(3)	28043803	42	41	42	12	16	8	2	13	3	0	0.188	1.000	1.000
479	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1)	22331141	43	39	43	15	21	7	7	5	3	0	0.295	1.000	1.000
480	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1)	22331141	43	39	43	15	21	7	7	5	3	0	0.295	1.000	1.000
481	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	80	ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2B(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(2), NEK3(2), OCRL(2), PAK4(3), PIK3C2A(1), PIK3C2B(3), PIK3CB(4), PIK3CG(7), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(2)	46320862	95	79	93	24	27	19	12	22	15	0	0.0544	1.000	1.000
482	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	51	AKR1C4(2), ARSE(3), CARM1(3), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(2), HSD17B3(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(2), SULT2B1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(4), UGT2B10(8), UGT2B11(2), UGT2B15(1), UGT2B7(2)	20062968	50	42	46	19	17	10	6	14	3	0	0.446	1.000	1.000
483	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	AGPAT1(2), AGPAT2(1), CHAT(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(3)	21394404	44	39	44	15	16	8	2	13	5	0	0.328	1.000	1.000
484	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(1), BTK(1), CSF2(2), FCER1A(2), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(2), MAPK13(1), MAPK3(1), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1)	29181446	74	60	72	24	24	15	10	16	9	0	0.238	1.000	1.000
485	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDKN1B(1), CDKN2A(2), CREB1(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(4), IRS2(1), IRS4(3), MET(3), MYC(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PARD3(1), PREX1(5), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(3), YWHAE(2), YWHAH(1)	31572288	49	43	49	13	11	6	8	10	14	0	0.360	1.000	1.000
486	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	BCL2(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), CHUK(1), GZMB(2), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(6), MDM2(2), MYC(1), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFSF10(2), TRAF1(1)	24130661	40	37	38	13	11	9	4	8	8	0	0.324	1.000	1.000
487	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(2), BCL2(2), DLG4(3), LPA(4), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PLD1(1), ROCK1(2), ROCK2(1), SRF(1)	20898391	35	30	33	11	7	13	3	6	6	0	0.373	1.000	1.000
488	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(5), ACACB(7), ACOT12(1), ACYP1(1), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), LDHAL6A(1), LDHAL6B(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1)	19872097	34	34	34	12	15	5	1	11	2	0	0.455	1.000	1.000
489	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	89	ACVR1C(2), ACVRL1(1), AMHR2(1), BMP2(1), BMP4(1), BMP5(4), BMP6(1), BMPR2(1), CDKN2B(2), CHRD(2), CREBBP(5), CUL1(3), DCN(1), E2F4(1), EP300(1), GDF5(1), GDF6(1), GDF7(1), ID1(1), IFNG(2), INHBA(1), INHBE(1), LEFTY2(2), MAPK1(2), MAPK3(1), MYC(1), PITX2(3), PPP2R1B(1), RBL1(2), ROCK1(2), ROCK2(1), SMAD4(1), SMAD7(1), SMURF1(2), SP1(1), TFDP1(1), TGFBR1(2), TGFBR2(2), THBS1(2), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1)	42205216	67	61	67	17	16	13	9	17	12	0	0.112	1.000	1.000
490	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	69	CALM1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITGB1BP3(1), ITPR1(5), ITPR2(3), ITPR3(5), OCRL(2), PI4KA(1), PI4KB(2), PIK3C2A(1), PIK3C2B(3), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PRKCA(1), PRKCG(2), SYNJ2(3)	50314460	101	79	100	25	40	17	6	23	15	0	0.0174	1.000	1.000
491	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	83	CHUK(1), CREB1(1), DAXX(3), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(2), MEF2D(1), MYC(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), SP1(1), STAT1(2), TGFBR1(2)	40278599	67	61	65	18	19	18	8	12	10	0	0.0958	1.000	1.000
492	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), APOA5(1), AQP7(2), CD36(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(4), CYP7A1(1), CYP8B1(2), EHHADH(1), FABP1(1), FABP6(1), GK2(1), ME1(1), MMP1(2), OLR1(1), PCK1(3), PLTP(1), PPARA(1), PPARG(1), RXRA(3), SLC27A1(1), SLC27A2(6), SLC27A6(4), SORBS1(2), UBC(2)	27848836	53	47	53	17	23	7	5	14	4	0	0.224	1.000	1.000
493	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	47	CD36(1), CREBBP(5), EHHADH(1), EP300(1), FABP1(1), HSD17B4(1), INS(1), MAPK1(2), MAPK3(1), ME1(1), MYC(1), NCOA1(1), NCOR1(1), NCOR2(2), NFKBIA(1), NR0B2(1), NRIP1(2), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RXRA(3), SP1(1), STAT5B(1)	24598649	34	34	34	12	10	6	2	7	9	0	0.467	1.000	1.000
494	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	78	AIFM1(2), AKT1(1), ATM(4), BCL2(2), BIRC2(1), BIRC3(1), CAPN1(2), CASP10(1), CASP9(1), CHUK(1), CSF2RB(4), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(2), IRAK2(1), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2)	33798138	64	58	63	20	20	12	7	15	10	0	0.248	1.000	1.000
495	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	APH1A(2), CREBBP(5), CTBP2(3), DLL1(1), DTX1(1), DTX2(1), DTX3L(1), DTX4(2), DVL1(1), DVL2(4), DVL3(1), EP300(1), HDAC2(3), HES1(1), JAG1(3), JAG2(4), LFNG(1), MAML1(2), MAML3(1), MFNG(1), NCOR2(2), NCSTN(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PSEN1(1), RBPJL(3)	29877976	54	49	53	18	12	10	9	12	11	0	0.424	1.000	1.000
496	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CALM1(1), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(5), DCT(1), DVL1(1), DVL2(4), DVL3(1), EP300(1), FZD1(1), FZD10(3), FZD9(1), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(2), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	46159722	89	78	86	25	33	18	11	16	11	0	0.0641	1.000	1.000
497	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), BTK(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), NR0B2(1), PITX2(3), PLCG2(3), PREX1(5), PTPRC(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(4)	22354448	44	41	44	16	16	12	4	4	8	0	0.262	1.000	1.000
498	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	185	ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC2(1), BIRC3(1), CAV3(1), CCND2(2), CCND3(1), COL11A1(2), COL11A2(7), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), CRKL(1), DOCK1(2), EGF(3), ELK1(2), ERBB2(1), FIGF(2), FLNA(5), FLNB(2), FLNC(3), FLT1(5), FN1(3), FYN(1), GRLF1(2), GSK3B(1), HGF(1), IGF1(2), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KDR(8), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), MAP2K1(1), MAPK1(2), MAPK3(1), MET(3), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PARVG(1), PDGFD(2), PDGFRB(3), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), RELN(13), ROCK1(2), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS1(2), THBS3(1), THBS4(2), TLN2(2), TNC(2), TNN(1), TNXB(3), VASP(1), VAV1(4), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VEGFC(1), VWF(7), ZYX(2)	152986838	305	169	302	124	102	60	34	66	43	0	0.456	1.000	1.000
499	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	166	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(4), AGTR1(1), ATP2A1(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), AVPR1A(2), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1F(1), CACNA1G(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CALM1(1), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), CYSLTR2(1), DRD1(1), ERBB2(1), GNA15(1), GRIN2A(10), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(2), GRPR(1), HRH2(3), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), ITPR1(5), ITPR2(3), ITPR3(5), LHCGR(2), MYLK(2), NOS1(6), NOS3(3), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRB(3), PHKA1(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PPID(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(3), RYR1(4), RYR2(30), RYR3(18), TACR3(4), TNNC2(1), TRPC1(1), VDAC1(1), VDAC2(1)	113472640	252	166	251	87	132	30	20	45	25	0	0.0349	1.000	1.000
500	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	135	COL11A1(2), COL11A2(7), COL17A1(3), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DES(3), DSC1(3), DSC2(3), DSC3(3), DSG1(2), DSG3(9), DSG4(5), FN1(3), GJA10(1), GJA9(1), GJB3(2), GJB4(1), GJC1(1), GJC3(1), GJD2(3), ITGB4(3), KRT1(1), KRT12(2), KRT13(3), KRT14(1), KRT15(2), KRT16(2), KRT17(1), KRT18(2), KRT2(1), KRT20(2), KRT23(1), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33A(2), KRT33B(1), KRT34(2), KRT35(1), KRT36(1), KRT37(4), KRT38(1), KRT39(2), KRT4(1), KRT40(2), KRT6B(1), KRT74(1), KRT75(2), KRT76(1), KRT79(3), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(3), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), LMNB2(1), NES(1), RELN(13), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(1), TNXB(3), VIM(1), VWF(7)	105264702	250	164	249	114	108	49	23	43	27	0	0.685	1.000	1.000
501	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	231	ADCYAP1R1(1), ADRA2B(1), ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), C5AR1(3), CALCRL(1), CCKAR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), CYSLTR2(1), DRD1(1), DRD2(1), DRD3(1), F2(1), F2RL3(2), FSHR(1), GABBR2(1), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRB1(1), GABRB3(6), GABRD(1), GABRE(2), GABRG1(2), GABRG2(4), GABRP(1), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GHRHR(1), GHSR(2), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(1), GLRA3(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(2), GRIK1(2), GRIK2(1), GRIK3(4), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRIN3A(2), GRIN3B(1), GRM1(4), GRM3(9), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LEPR(1), LHCGR(2), MC2R(3), MC3R(4), MC4R(3), MC5R(2), MCHR1(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX2(1), P2RX5(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY8(3), PARD3(1), PPYR1(1), PRLHR(1), PRSS1(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(1), SSTR4(4), SSTR5(1), TAAR1(1), TACR3(4), THRA(1), TRPV1(2), TSHR(1), UTS2R(1), VIPR2(1)	92232641	252	162	251	116	142	32	19	47	12	0	0.447	1.000	1.000
502	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	84	AGRN(2), CD36(1), CD44(3), COL11A1(2), COL11A2(7), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(4), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DAG1(2), FN1(3), FNDC1(3), FNDC4(1), HSPG2(8), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(8), LAMA2(7), LAMA3(4), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), RELN(13), SDC1(1), SDC2(1), SDC4(1), SV2B(2), SV2C(2), THBS1(2), THBS3(1), THBS4(2), TNC(2), TNN(1), TNXB(3), VWF(7)	95105189	202	142	202	83	74	46	22	32	28	0	0.360	1.000	1.000
503	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1C(2), AKT1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1F(1), CACNA1G(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB3(2), CACNG2(1), CACNG3(2), CHUK(1), CRKL(1), DAXX(3), DDIT3(1), DUSP10(1), DUSP5(1), DUSP8(1), EGF(3), ELK1(2), ELK4(1), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FLNA(5), FLNB(2), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MYC(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(1), PAK1(1), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PPM1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RAPGEF2(1), RASGRF1(3), RASGRF2(2), RASGRP1(1), RASGRP2(2), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), STK3(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(2), TGFBR2(2), TNFRSF1A(1), ZAK(3)	117262834	214	140	208	80	78	41	23	42	30	0	0.340	1.000	1.000
504	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	198	ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(3), ARHGEF12(1), ARHGEF6(2), ARHGEF7(2), ARPC2(1), BDKRB1(1), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGF(3), EZR(4), F2(1), FGD3(2), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FN1(3), GRLF1(2), GSN(1), INS(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(5), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(2), LIMK2(2), MAP2K1(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(1), MYH14(3), MYH9(3), MYLK(2), NCKAP1(1), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PDGFRB(3), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PPP1CC(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(5), TMSL3(1), VAV1(4), VAV2(2), VAV3(1), WAS(1)	114054954	197	137	193	78	74	24	21	52	26	0	0.675	1.000	1.000
505	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP1A4(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(6), CACNA1S(7), CACNB3(2), CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GJB4(1), GNAO1(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(18), SFN(1), YWHAH(1)	80603643	186	133	184	60	84	30	18	36	18	0	0.0335	1.000	1.000
506	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL19(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CD70(1), CSF1R(1), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL6(1), EDA(1), EDAR(1), EGF(3), EPO(1), FLT1(5), FLT3(4), FLT4(2), GDF5(1), GH1(1), HGF(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL15RA(1), IL17RA(2), IL17RB(1), IL18R1(2), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), INHBA(1), INHBE(1), KDR(8), KIT(3), KITLG(1), LEPR(1), MET(3), MPL(3), OSM(1), OSMR(2), PDGFRB(3), PPBP(1), RELT(1), TGFBR1(2), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(2), TNFSF18(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFB(1), VEGFC(1), XCL1(2), XCR1(1)	73099447	171	123	168	78	70	22	12	49	18	0	0.774	1.000	1.000
507	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(1), ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP2A3(2), CACNB3(2), CALCA(1), CALM1(1), CAMK2A(1), CNN2(1), CORIN(2), DGKZ(1), FOS(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), GUCY1A3(1), IL1B(1), IL6(1), ITPR1(5), ITPR2(3), ITPR3(5), MIB1(4), NFKB1(1), NOS1(6), NOS3(3), PDE4B(1), PLCD1(3), PLCG1(6), PLCG2(3), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(2), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(18), SFN(1), SP1(1), TNXB(3), YWHAH(1)	74334597	164	122	163	50	74	23	14	34	19	0	0.0190	1.000	1.000
508	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CSDA(1), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L2(2), EPB41L3(5), F11R(1), HCLS1(3), INADL(2), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MAGI3(1), MLLT4(4), MPDZ(1), MYH1(6), MYH10(1), MYH11(5), MYH13(8), MYH14(3), MYH15(3), MYH2(9), MYH3(2), MYH4(5), MYH6(2), MYH7(4), MYH7B(3), MYH8(7), MYH9(3), NRAS(1), OCLN(1), PARD3(1), PARD6B(2), PPM1J(2), PPP2R1B(1), PPP2R3A(2), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), SPTAN1(3), SRC(2), SYMPK(3), TJAP1(2), TJP1(3), TJP3(5), ZAK(3)	82436916	155	114	153	41	70	23	14	28	20	0	0.0200	1.000	1.000
509	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(2), ABLIM3(4), ARHGEF12(1), CFL2(1), DCC(6), DPYSL5(2), EFNA3(1), EFNA5(2), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(3), EPHA4(1), EPHA5(4), EPHA6(4), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(3), EPHB4(2), EPHB6(4), FES(1), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(5), LIMK2(2), LRRC4C(2), MAPK1(2), MAPK3(1), MET(3), NFATC2(2), NFATC4(2), NGEF(1), NRAS(1), NRP1(1), NTN1(2), NTN4(3), NTNG1(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PLXNA1(1), PLXNA2(3), PLXNA3(1), PLXNB1(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(3), SLIT3(9), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5C(3), UNC5D(1)	83118926	144	110	141	55	41	27	19	40	17	0	0.502	1.000	1.000
510	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CHML(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(2), DRD1(1), DRD2(1), DRD3(1), F2RL3(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37(2), GPR4(2), GPR50(1), GPR6(1), GPR77(1), GPR83(2), GPR85(2), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LHCGR(2), MC3R(4), MC4R(3), MC5R(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR1C1(1), OR1F1(1), OR2H1(3), OR7A5(1), OR7C1(1), P2RY10(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR2(1), SSTR3(1), SSTR4(4), SUCNR1(1)	51261339	132	107	131	60	86	17	7	17	5	0	0.226	1.000	1.000
511	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	CADM1(1), CADM3(1), CD2(1), CD22(6), CD276(1), CD28(1), CD4(1), CD58(1), CD6(2), CD86(2), CD8A(1), CDH15(2), CDH4(2), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(1), F11R(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(2), ITGAM(5), ITGAV(1), ITGB1(1), ITGB2(5), ITGB7(3), ITGB8(1), L1CAM(5), MAG(3), MPZL1(2), NCAM1(2), NEGR1(2), NEO1(1), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(2), NRXN1(5), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PTPRC(2), PTPRF(5), PTPRM(3), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(2), SELP(2), SELPLG(2), SIGLEC1(2), VCAM1(1), VCAN(3)	61929128	131	103	131	64	63	14	13	28	13	0	0.833	1.000	1.000
512	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(1), ACTN3(1), DES(3), DMD(11), FAM48A(2), MYBPC3(1), MYH3(2), MYH6(2), MYH7(4), MYH8(7), MYL3(1), MYOM1(2), NEB(6), TMOD1(1), TNNC2(1), TNNT1(3), TNNT2(1), TPM3(1), TTN(95), VIM(1)	58581110	146	103	144	35	60	17	12	42	15	0	0.0241	1.000	1.000
513	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	149	AKT1(1), CBL(1), CBLB(1), CCND2(2), CCND3(1), CREBBP(5), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), EP300(1), EPO(1), GH1(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), IRF9(1), JAK1(2), JAK2(2), JAK3(2), LEPR(1), MPL(3), MYC(1), OSM(1), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), PTPN6(1), SOCS1(1), SOCS4(1), SOS1(3), SPRY3(2), STAM2(1), STAT1(2), STAT2(1), STAT3(1), STAT4(2), STAT5B(1), STAT6(1), TPO(4), TYK2(3)	60254473	132	101	131	47	47	22	12	35	16	0	0.364	1.000	1.000
514	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	128	ACACA(5), ACACB(7), AKT1(1), CALM1(1), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(2), FBP2(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INS(1), INSR(2), IRS1(4), IRS2(1), IRS4(3), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PCK1(3), PDE3A(3), PDE3B(3), PFKL(1), PHKA1(2), PHKG1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(1), PPP1CC(1), PPP1R3A(7), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(5), PYGB(2), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS1(1), SOCS4(1), SORBS1(2), SOS1(3), SREBF1(1), TRIP10(1), TSC2(3)	66370419	120	97	119	41	42	20	10	37	11	0	0.293	1.000	1.000
515	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	90	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(1), DRD2(1), EGF(3), GJD2(3), GRM1(4), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK7(1), NPR1(1), NRAS(1), PDGFD(2), PDGFRB(3), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(3), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3)	54296036	115	94	113	38	50	22	9	19	15	0	0.111	1.000	1.000
516	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CTNNA1(2), CTNNA2(2), CTNNA3(2), CYBB(1), EZR(4), F11R(1), GRLF1(2), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(5), MAPK13(1), MLLT4(4), MMP9(2), MSN(1), NCF1(1), NCF2(2), NOX3(5), OCLN(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), RASSF5(1), ROCK1(2), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(4), VAV2(2), VAV3(1), VCAM1(1)	51497384	119	94	118	51	49	13	11	31	15	0	0.735	1.000	1.000
517	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(7), CALM1(1), CAMK2A(1), CGA(1), ELK1(2), GNRHR(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K4(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2)	53483380	108	90	104	31	46	27	7	18	10	0	0.0206	1.000	1.000
518	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	CD244(1), CSF2(2), FYN(1), GZMB(2), ICAM1(1), ICAM2(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), ITGB2(5), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(2), NFATC2(2), NFATC4(2), NRAS(1), PAK1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PTPN6(1), RAF1(1), SH2D1A(1), SH2D1B(2), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3)	46217944	113	88	112	45	32	17	17	32	15	0	0.532	1.000	1.000
519	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AK1(1), AK5(1), AK7(5), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NME7(2), NPR1(1), NT5C1B(2), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(3), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PFAS(1), PKLR(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), PRPS1L1(2), PRPS2(2), RRM2(1), XDH(3)	69759151	107	86	106	31	43	22	11	20	11	0	0.0513	1.000	1.000
520	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	106	ABL1(2), ANAPC1(2), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC23(2), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CHEK1(3), CHEK2(4), CREBBP(5), CUL1(3), DBF4(1), EP300(1), ESPL1(3), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), ORC3L(1), ORC5L(1), PRKDC(4), RBL1(2), SFN(1), SKP2(1), SMAD4(1), SMC1A(6), SMC1B(2), TFDP1(1), WEE1(1), YWHAE(2), YWHAH(1)	56332021	102	85	100	26	10	21	13	35	23	0	0.137	1.000	1.000
521	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(1), APC2(3), AXIN1(3), AXIN2(1), BTRC(1), CAMK2A(1), CCND2(2), CCND3(1), CHD8(10), CREBBP(5), CSNK2B(2), CTBP2(3), CUL1(3), CXXC4(1), DAAM2(1), DKK1(1), DKK2(3), DVL1(1), DVL2(4), DVL3(1), EP300(1), FBXW11(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LRP6(2), MAP3K7(3), MMP7(2), MYC(1), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), ROCK1(2), ROCK2(1), RUVBL1(2), SMAD4(1), SOX17(1), TBL1X(1), TCF7L2(2), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1)	68386594	106	85	105	34	35	14	11	21	25	0	0.238	1.000	1.000
522	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(2), CD19(1), CD1B(1), CD1D(4), CD1E(2), CD2(1), CD22(6), CD33(5), CD36(1), CD37(1), CD38(1), CD3E(2), CD3G(1), CD4(1), CD44(3), CD5(2), CD55(1), CD59(1), CD7(2), CD8A(1), CR2(4), CSF1R(1), CSF2(2), CSF2RA(1), CSF3R(1), DNTT(2), EPO(1), FCER2(1), FLT3(4), GYPA(1), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IL9R(1), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(5), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(4)	34810141	103	84	102	36	49	12	7	19	16	0	0.208	1.000	1.000
523	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), CAPN1(2), CAPN11(2), CAPN6(2), CAPNS1(1), CAV3(1), CSK(1), DOCK1(2), FYN(1), ITGA10(3), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(5), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK3(1), PAK4(3), PIK3R2(3), PXN(1), ROCK1(2), ROCK2(1), SDCCAG8(2), SORBS1(2), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2)	57336327	96	81	96	35	37	15	9	24	11	0	0.340	1.000	1.000
524	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	77	AGL(1), AMY2B(3), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), ENPP1(1), EP400(6), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), MOV10L1(4), PGM1(1), PYGB(2), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(3), SMARCA2(3), SMARCA5(1), TREH(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(4), UGT2B10(8), UGT2B11(2), UGT2B15(1), UGT2B7(2), UXS1(2)	51423509	86	75	83	31	32	11	10	25	8	0	0.535	1.000	1.000
525	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(1), BCL10(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CD4(1), CD8A(1), CHUK(1), CSF2(2), FOS(1), FYN(1), GRAP2(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PDCD1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PRKCQ(2), PTPN6(1), PTPRC(2), RASGRP1(1), SOS1(3), TEC(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3)	41672988	90	72	89	30	28	16	11	22	13	0	0.294	1.000	1.000
526	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	73	CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(2), GRM1(4), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IGF1(2), IGF1R(3), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), LYN(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOS1(6), NOS3(3), NPR1(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), RAF1(1), RYR1(4)	46566572	83	72	82	38	37	16	5	15	10	0	0.686	1.000	1.000
527	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(2), ACTN1(2), AKT1(1), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), CDKN2A(2), CSE1L(1), DOCK1(2), EPHB2(3), FYN(1), GRB7(2), GRLF1(2), ITGA1(2), ITGA10(3), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), MAPK1(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(2), P4HB(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CB(4), PKLR(1), PLCG1(6), PLCG2(3), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SRC(2), TERF2IP(1), TLN2(2), VASP(1), WAS(1), ZYX(2)	50241553	88	71	88	29	22	13	14	21	18	0	0.379	1.000	1.000
528	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(2), ATM(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), CHEK2(4), DTX4(2), E2F4(1), E2F6(1), EP300(1), ESPL1(3), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(3), ORC3L(1), ORC5L(1), PRKDC(4), PTPRA(3), RBL1(2), SKP2(1), SMAD4(1), TBC1D8(3), TFDP1(1), WEE1(1)	46008277	79	70	77	22	17	15	8	26	13	0	0.215	1.000	1.000
529	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	BCL2(2), CABIN1(5), CALM1(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CEBPB(1), CREBBP(5), CSF2(2), CSNK2B(2), EGR2(2), EGR3(1), EP300(1), FCER1A(2), FOS(1), GATA4(2), GRLF1(2), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MEF2A(2), MEF2D(1), MYF5(2), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(1), PAK1(1), PPP3CB(1), PTPRC(2), RPL13A(1), SFN(1), SP1(1), SP3(1), TRPV6(7), VAV1(4), VAV2(2), VAV3(1)	38766387	79	68	79	25	21	13	11	18	16	0	0.196	1.000	1.000
530	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	66	ADCY1(3), ADCY8(2), CACNA1C(5), CALM1(1), CAMK2A(1), CAMK4(1), CREBBP(5), EP300(1), GRIA1(2), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRM1(4), GRM5(2), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP1CC(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2)	42060018	82	68	81	29	40	14	7	14	7	0	0.214	1.000	1.000
531	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTN1(2), ACTN3(1), ACVR1C(2), CREBBP(5), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), EP300(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(3), INSR(2), LMO7(2), MAP3K7(3), MAPK1(2), MAPK3(1), MET(3), MLLT4(4), PARD3(1), PTPN6(1), PTPRB(3), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(3), SMAD4(1), SNAI2(2), SORBS1(2), SRC(2), TCF7L2(2), TGFBR1(2), TGFBR2(2), TJP1(3), WAS(1), WASF3(1)	49773531	80	67	80	31	20	15	11	19	15	0	0.593	1.000	1.000
532	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), ATP5I(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(2), PDE4B(1), PDE6B(2), PDE8A(1), PFAS(1), PKLR(1), POLD1(1), POLE(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3), PRPS1L1(2), PRPS2(2), RRM2(1)	54769909	79	67	79	25	33	13	5	17	11	0	0.233	1.000	1.000
533	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	42	ABCA1(1), ABCA10(4), ABCA12(1), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(3), ABCA7(2), ABCA9(3), ABCB11(2), ABCB4(6), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(1), ABCC10(2), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(1), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), ABCG5(1), ABCG8(1), CFTR(2), TAP1(1), TAP2(4)	48161734	77	65	76	32	28	13	9	20	7	0	0.536	1.000	1.000
534	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	80	ABL1(2), ABL2(2), AKT1(1), AREG(1), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CDKN1B(1), CRKL(1), EGF(3), ELK1(2), ERBB2(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MYC(1), NRAS(1), NRG1(2), NRG4(1), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2), STAT5B(1)	40529884	74	65	73	25	19	14	9	23	9	0	0.426	1.000	1.000
535	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IKBKB(1), IL12B(2), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(3), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(2), TLR1(2), TLR2(4), TLR3(1), TLR5(2), TLR6(5), TLR7(4), TLR8(1), TLR9(2)	36573945	80	64	80	29	30	17	6	16	11	0	0.268	1.000	1.000
536	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(1), BCL10(1), BTK(1), CARD11(5), CD19(1), CD22(6), CHUK(1), CR2(4), FOS(1), GSK3B(1), IFITM1(2), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(3), PPP3CB(1), PTPN6(1), VAV1(4), VAV2(2), VAV3(1)	30152833	75	63	74	31	27	17	5	17	9	0	0.502	1.000	1.000
537	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	CARM1(3), DOT1L(1), EHMT2(2), EZH2(3), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(3), MEN1(3), MLL(3), MLL2(6), MLL3(10), MLL4(5), MLL5(1), NSD1(1), OGT(1), PPP1CC(1), PRDM7(1), PRDM9(10), PRMT8(1), RBBP5(2), SETD1A(3), SETD2(3), SETDB1(1), SMYD3(2), SUV39H2(1), SUV420H1(1), SUZ12(1)	51005383	72	61	71	23	14	15	7	27	9	0	0.508	1.000	1.000
538	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), CHSY1(2), EXT2(1), EXTL1(1), FUT8(1), GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), HS3ST1(2), HS3ST3A1(2), MAN1A1(1), MGAT2(1), MGAT4B(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(6), OGT(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(7), XYLT1(1), XYLT2(2)	46948191	68	59	68	26	30	10	8	12	8	0	0.393	1.000	1.000
539	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(7), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), AKT1(1), CAMKK1(1), CD36(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(4), IRS2(1), IRS4(3), JAK1(2), JAK2(2), JAK3(2), LEPR(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(3), PPARA(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(4), RXRA(3), SLC2A1(2), STAT3(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(3)	35384183	63	59	63	22	22	10	3	17	11	0	0.395	1.000	1.000
540	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), COL2A1(2), CPSF1(4), CSTF1(1), CSTF2(1), DDIT3(1), DDX20(1), DHX38(1), DHX8(1), DICER1(5), FUS(1), LOC440563(2), NCBP2(1), NONO(2), NUDT21(1), NXF1(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(2), SF3B2(2), SF3B4(1), SFRS16(1), SFRS2(1), SFRS5(2), SFRS8(2), SNRPB(1), SRPK1(2), SRPK2(1), SRRM1(1)	45065784	58	54	58	13	17	7	8	11	15	0	0.187	1.000	1.000
541	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(3), ADCY4(1), ADCY6(2), ADCY8(2), CACNA1A(1), CACNA1B(6), GNAT3(4), GNB1(1), GRM4(2), ITPR3(5), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(3), SCNN1G(4), TAS1R1(3), TAS1R2(2), TAS2R1(2), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R41(4), TAS2R5(1), TAS2R60(1), TRPM5(1)	24513275	60	53	58	28	30	7	6	8	9	0	0.744	1.000	1.000
542	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCL2(2), BTK(1), CD19(1), CD22(6), CR2(4), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(2), NR0B2(1), PLCG2(3), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(4)	30000344	60	51	60	21	23	12	6	9	10	0	0.258	1.000	1.000
543	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	CCR3(1), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(5), CHRM2(3), CHRM3(1), EMR2(1), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(6), GPR132(2), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GPR77(1), GRM1(4), GRPR(1), LGR6(1), LPHN2(1), LPHN3(2), NTSR1(3), OR2M4(2), OR8G2(1), PTGFR(1), SMO(1), SSTR2(1), TSHR(1)	28459266	57	50	57	37	31	4	5	14	3	0	0.978	1.000	1.000
544	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), ITGB1BP3(1), MIOX(1), OCRL(2), PI4KA(1), PI4KB(2), PIK3CB(4), PIK3CG(7), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), SYNJ2(3)	30401593	55	44	55	19	19	7	5	16	8	0	0.430	1.000	1.000
545	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BTK(1), CAD(3), CASP10(1), CASP8AP2(1), CD7(2), DAXX(3), DEDD(1), DEDD2(1), EPHB2(3), FAF1(1), IL1A(1), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), TPX2(2)	29800546	52	44	50	17	14	14	12	7	5	0	0.281	1.000	1.000
546	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(3), PTPN11(4), PTPRZ1(3), SRC(2), TJP1(3)	28729642	52	43	52	17	12	11	6	16	7	0	0.350	1.000	1.000
547	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(4), CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NME7(2), NT5C1B(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(2), UCK1(1), UPP1(2), UPP2(1)	34619747	48	40	47	14	10	12	9	13	4	0	0.229	1.000	1.000
548	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	AKT1(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(2), BTK(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(5), MYLK(2), PAK1(1), PAK3(1), PAK4(3), PAK7(1), PIK3CG(7), PITX2(3), ROCK1(2), ROCK2(1), RPS4X(1)	28115546	47	40	47	16	20	12	2	3	10	0	0.249	1.000	1.000
549	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(2), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PFKL(1), PGAM4(1), PGK1(1), PGK2(1), PGM1(1), PKLR(1)	24734126	41	38	41	17	17	6	2	13	3	0	0.561	1.000	1.000
550	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPP(3), ALPPL2(4), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), EP400(6), MOV10L1(4), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1)	26755541	40	38	40	13	14	8	4	10	4	0	0.383	1.000	1.000
551	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(1), CANX(1), CD4(1), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HSP90AB1(2), IFNA10(2), IFNA21(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), NFYB(1), PDIA3(1), RFX5(1), TAP1(1), TAP2(4)	19797348	42	37	42	21	17	7	5	8	5	0	0.842	1.000	1.000
552	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1)	20727978	38	35	38	16	18	7	1	10	2	0	0.544	1.000	1.000
553	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1)	20727978	38	35	38	16	18	7	1	10	2	0	0.544	1.000	1.000
554	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	21	INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(3), PIK3CB(4), PIK3CG(7), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3)	17094147	41	34	40	15	12	6	2	12	9	0	0.701	1.000	1.000
555	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(1), AMY2B(3), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), PGM1(1), PYGB(2), PYGL(1), PYGM(1), SI(3), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1), UXS1(2)	23876964	37	34	37	19	19	3	3	7	5	0	0.867	1.000	1.000
556	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	50	ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2U1(1), CYP4A11(4), CYP4F2(3), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1)	16390339	37	33	37	14	19	4	1	10	3	0	0.413	1.000	1.000
557	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), GOT2(1), HK2(2), HK3(2), LDHAL6B(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PFKL(1), PGK1(1), PGK2(1), PKLR(1), TNFAIP1(1)	18024623	31	31	31	16	13	5	1	10	2	0	0.781	1.000	1.000
558	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALNT1(2), B3GALT5(1), B3GNT3(2), B4GALNT1(1), B4GALT2(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GBGT1(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL6(2), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1)	20709753	31	31	31	12	10	3	3	11	4	0	0.703	1.000	1.000
559	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), LYN(2), MAP2K1(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PLCG2(3), RAF1(1), SOS1(3), VAV1(4)	20832329	32	31	32	14	5	11	6	6	4	0	0.652	1.000	1.000
560	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), DLD(2), DUSP10(1), DUSP8(1), IL1R1(2), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK7(1), NR2C2(1), PAPPA(2), ZAK(3)	21102017	32	31	30	13	7	13	5	5	2	0	0.601	1.000	1.000
561	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NT5E(2), NUDT2(1), POLD1(1), POLE(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(3), RRM2(1), TXNRD1(1), UCK1(1), UPP1(2)	24465057	33	30	33	12	4	6	6	12	5	0	0.709	1.000	1.000
562	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP4A(1), ATP5A1(1), ATP5B(1), ATP5I(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), COX10(2), COX7C(1), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA13(1), NDUFA4(1), NDUFA9(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1)	23808656	30	28	30	11	11	5	4	8	2	0	0.512	1.000	1.000
563	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	22	RPE(1), UGDH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2A1(4), UGT2B10(8), UGT2B11(2), UGT2B15(1), UGT2B7(2), XYLB(1)	10216962	28	27	25	12	8	3	5	10	2	0	0.759	1.000	1.000
564	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(1), WBSCR17(7)	13697206	29	27	29	10	13	4	1	6	5	0	0.530	1.000	1.000
565	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(4), GRM1(4), GRM3(9), GRM4(2), GRM5(2), GRM7(2), GRM8(5)	8891338	28	26	27	22	20	0	1	6	1	0	0.978	1.000	1.000
566	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(5), CALM1(1), CAMK1(1), IGF1(2), IGF1R(3), INS(1), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PPP3CB(1), SYT1(1), YWHAH(1)	13246561	26	25	26	11	6	4	5	7	4	0	0.566	1.000	1.000
567	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(2), AADAC(1), ACADS(4), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(3), PLA1A(1), PPME1(1)	17297037	25	25	25	10	10	5	2	4	4	0	0.547	1.000	1.000
568	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	46	AASS(3), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1), HSD17B4(1), NSD1(1), OGDHL(3), PIPOX(1), SETD1A(3), SETDB1(1), SUV39H2(1)	23871504	24	24	23	11	9	5	0	6	4	0	0.810	1.000	1.000
569	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(5), SELP(2), SELPLG(2), VCAM1(1)	10566078	25	24	25	14	7	3	3	7	5	0	0.872	1.000	1.000
570	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(1), B4GALT2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PFKL(1), PGM1(1)	16526838	24	23	24	10	12	4	2	4	2	0	0.549	1.000	1.000
571	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSE(3), ASAH1(1), B4GALT6(1), ENPP7(4), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2), SGMS2(1), SGPP2(2), UGT8(1)	15338876	24	23	24	14	10	6	2	5	1	0	0.802	1.000	1.000
572	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(2), SRC(2)	19525115	24	23	23	13	5	5	3	7	4	0	0.903	1.000	1.000
573	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(2), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(2), HSD17B3(1), SRD5A1(1), SRD5A2(1), STS(2), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2), UGT2B15(1)	11183016	24	22	24	13	9	6	2	5	2	0	0.744	1.000	1.000
574	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	B4GALT2(1), FBP2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PGM1(1)	13915704	23	22	23	12	11	4	2	4	2	0	0.752	1.000	1.000
575	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(2), CYP3A5(5), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A8(1), UGT1A9(2)	9660684	22	22	22	10	11	1	4	4	2	0	0.537	1.000	1.000
576	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(1), AXIN1(3), CREBBP(5), DVL1(1), EP300(1), FZD1(1), GSK3B(1), PITX2(3), TRRAP(6), WNT1(1)	14119985	23	22	23	11	4	5	3	5	6	0	0.820	1.000	1.000
577	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(3), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(5), SELE(2), SELP(2)	6811851	22	21	22	15	10	1	3	5	3	0	0.897	1.000	1.000
578	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	19	ADCYAP1R1(1), CALCRL(1), CD97(1), CRHR2(2), ELTD1(5), EMR1(1), EMR2(1), GHRHR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(2), VIPR2(1)	11060580	22	20	22	10	8	0	3	9	2	0	0.759	1.000	1.000
579	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	CBL(1), EGF(3), MAP2K1(1), MAPK1(2), MAPK3(1), PTPRB(3), RAF1(1), SOS1(3), SPRY3(2), SRC(2)	9483318	19	19	19	11	3	2	3	9	2	0	0.941	1.000	1.000
580	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(1), RELN(13)	5950091	18	18	18	10	6	2	4	2	4	0	0.729	1.000	1.000
581	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1)	15800659	17	17	15	11	8	3	0	2	4	0	0.950	1.000	1.000
582	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(1), ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), PFKFB1(2), PFKFB4(1), PFKL(1), PMM1(1)	15893761	17	16	17	12	11	1	2	2	1	0	0.916	1.000	1.000
583	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(1), AGPAT6(1), ENPP2(4), ENPP6(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1)	9880343	16	16	16	8	9	2	0	5	0	0	0.767	1.000	1.000
584	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PFKL(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1), TKTL1(1), TKTL2(1)	10352264	15	15	15	9	8	2	2	3	0	0	0.815	1.000	1.000
585	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(5), SELE(2)	5171941	15	15	15	11	6	1	2	3	3	0	0.900	1.000	1.000
586	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(3), ICAM1(1), ITGAM(5), ITGB2(5), SELE(2)	4461475	16	15	16	12	8	0	2	3	3	0	0.915	1.000	1.000
587	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSE(3), ASAH1(1), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2)	10365168	15	14	15	11	6	3	1	4	1	0	0.928	1.000	1.000
588	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5C1B(2), NT5E(2), NUDT12(1)	9152517	14	14	13	9	5	3	3	3	0	0	0.843	1.000	1.000
589	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), SPAM1(4)	8756292	13	13	12	7	6	3	0	4	0	0	0.790	1.000	1.000
590	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), PGK1(1), PGK2(1), PKLR(1), RPE(1), TKTL1(1), TKTL2(1)	8542740	12	12	12	10	5	2	0	5	0	0	0.972	1.000	1.000
591	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1)	8685122	12	12	12	8	5	2	2	3	0	0	0.882	1.000	1.000
592	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), ME2(1), PGK1(1), PKLR(1), RPE(1)	7645487	10	10	10	8	3	2	0	5	0	0	0.964	1.000	1.000
593	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1)	4722990	8	8	8	5	3	3	0	2	0	0	0.834	1.000	1.000
594	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALNT1(2), B3GALT5(1), GBGT1(1), ST3GAL1(1), ST8SIA1(1)	4560397	6	6	6	6	1	0	0	5	0	0	0.992	1.000	1.000
595	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(1), FYN(1), THBS1(2)	3125230	5	5	5	4	2	1	1	1	0	0	0.869	1.000	1.000
596	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGEF2(3), KDELR1(1)	6871795	4	4	4	4	1	2	0	1	0	0	0.939	1.000	1.000
597	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), PFKL(1), PGK1(1), PKLR(1)	3943946	4	4	4	3	2	0	0	2	0	0	0.904	1.000	1.000
598	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT5(1), FUT3(2)	3062162	4	4	4	3	3	0	0	1	0	0	0.869	1.000	1.000
599	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EGF(3)	4322532	3	3	3	4	0	0	0	3	0	0	0.993	1.000	1.000
600	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), GPD2(1), UQCRC1(1)	2803186	3	3	3	3	0	1	1	1	0	0	0.927	1.000	1.000
601	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	GBGT1(1), ST3GAL1(1), ST8SIA1(1)	4298312	3	3	3	6	1	0	0	2	0	0	0.999	1.000	1.000
602	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	LCT(3)	6135585	3	3	3	6	1	1	0	1	0	0	0.996	1.000	1.000
603	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(1), PON1(2)	3832924	3	3	3	5	1	0	0	2	0	0	0.997	1.000	1.000
604	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(1), PRKAR2B(1)	4277470	2	2	2	2	0	0	0	2	0	0	0.955	1.000	1.000
605	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	NDUFA12(1), NDUFA13(1)	1725322	2	2	2	2	2	0	0	0	0	0	0.900	1.000	1.000
606	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	ESCO1(1), MYST4(1)	7032636	2	2	2	2	0	2	0	0	0	0	0.893	1.000	1.000
607	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(1)	2054840	1	1	1	2	1	0	0	0	0	0	0.981	1.000	1.000
608	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	P2RY2(1)	2526610	1	1	1	2	1	0	0	0	0	0	0.945	1.000	1.000
609	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR2(1)	2661386	1	1	1	2	0	0	1	0	0	0	0.985	1.000	1.000
610	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		214514	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3		948253	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
612	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4		1319270	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
613	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		647612	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		722306	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9		1820179	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4		1430860	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
