Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	62.0	498.0	8.0	-0.307	0.152	1000.0	-1000.0	-0.016	-1000.0
TCGA08_p53	48.0	339.0	7.0	-0.233	0.119	1000.0	-1000.0	-0.012	-1000.0
Syndecan-1-mediated signaling events	38.0	1322.0	34.0	-0.282	0.013	1000.0	-1000.0	-0.055	-1000.0
IL23-mediated signaling events	35.0	2130.0	60.0	-0.661	0.013	1000.0	-1000.0	-0.159	-1000.0
IL4-mediated signaling events	30.0	2743.0	91.0	-0.661	0.578	1000.0	-1000.0	-0.139	-1000.0
Signaling events mediated by the Hedgehog family	27.0	1448.0	52.0	-0.217	0.211	1000.0	-1000.0	-0.078	-1000.0
TCR signaling in naïve CD8+ T cells	27.0	2565.0	93.0	-0.236	0.111	1000.0	-1000.0	-0.074	-1000.0
Wnt signaling	27.0	193.0	7.0	-0.142	0.005	1000.0	-1000.0	-0.028	-1000.0
IL12-mediated signaling events	25.0	2225.0	87.0	-0.407	0.093	1000.0	-1000.0	-0.123	-1000.0
Glypican 2 network	24.0	99.0	4.0	-0.078	-1000.0	1000.0	-1000.0	-0.031	-1000.0
amb2 Integrin signaling	22.0	1876.0	82.0	-0.233	0.013	1000.0	-1000.0	-0.08	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1540.0	68.0	-0.399	0.146	1000.0	-1000.0	-0.117	-1000.0
Syndecan-4-mediated signaling events	22.0	1532.0	67.0	-0.292	0.035	1000.0	-1000.0	-0.098	-1000.0
Glucocorticoid receptor regulatory network	21.0	2492.0	114.0	-0.68	0.384	1000.0	-1000.0	-0.079	-1000.0
BMP receptor signaling	18.0	1462.0	81.0	-0.263	0.035	1000.0	-1000.0	-0.086	-1000.0
BCR signaling pathway	18.0	1855.0	99.0	-0.228	0.013	1000.0	-1000.0	-0.082	-1000.0
Noncanonical Wnt signaling pathway	17.0	457.0	26.0	-0.16	0.013	1000.0	-1000.0	-0.063	-1000.0
HIF-1-alpha transcription factor network	17.0	1322.0	76.0	-0.389	0.021	1000.0	-1000.0	-0.131	-1000.0
p75(NTR)-mediated signaling	17.0	2187.0	125.0	-0.255	0.013	1000.0	-1000.0	-0.093	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	765.0	44.0	-0.138	0.013	1000.0	-1000.0	-0.051	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	538.0	31.0	-0.265	0.013	1000.0	-1000.0	-0.085	-1000.0
Caspase cascade in apoptosis	16.0	1237.0	74.0	-0.143	0.077	1000.0	-1000.0	-0.053	-1000.0
Thromboxane A2 receptor signaling	15.0	1637.0	105.0	-0.124	0.035	1000.0	-1000.0	-0.066	-1000.0
IL27-mediated signaling events	15.0	794.0	51.0	-0.252	0.085	1000.0	-1000.0	-0.074	-1000.0
Class IB PI3K non-lipid kinase events	15.0	45.0	3.0	-0.045	-1000.0	1000.0	-1000.0	-0.005	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1408.0	97.0	-0.17	0.032	1000.0	-1000.0	-0.086	-1000.0
Endothelins	14.0	1397.0	96.0	-0.18	0.02	1000.0	-1000.0	-0.076	-1000.0
Reelin signaling pathway	13.0	752.0	56.0	-0.159	0.013	1000.0	-1000.0	-0.084	-1000.0
Signaling events regulated by Ret tyrosine kinase	13.0	1131.0	82.0	-0.138	0.013	1000.0	-1000.0	-0.084	-1000.0
LPA receptor mediated events	13.0	1400.0	102.0	-0.177	0.021	1000.0	-1000.0	-0.092	-1000.0
JNK signaling in the CD4+ TCR pathway	12.0	208.0	17.0	-0.083	0.013	1000.0	-1000.0	-0.059	-1000.0
Syndecan-2-mediated signaling events	12.0	836.0	69.0	-0.169	0.039	1000.0	-1000.0	-0.043	-1000.0
Glypican 1 network	12.0	598.0	48.0	-0.215	0.015	1000.0	-1000.0	-0.048	-1000.0
IL1-mediated signaling events	12.0	774.0	62.0	-0.203	0.064	1000.0	-1000.0	-0.086	-1000.0
Ephrin B reverse signaling	12.0	594.0	48.0	-0.088	0.069	1000.0	-1000.0	-0.065	-1000.0
IL6-mediated signaling events	12.0	954.0	75.0	-0.142	0.061	1000.0	-1000.0	-0.094	-1000.0
Visual signal transduction: Rods	12.0	637.0	52.0	-0.199	0.013	1000.0	-1000.0	-0.077	-1000.0
Coregulation of Androgen receptor activity	11.0	901.0	76.0	-0.354	0.025	1000.0	-1000.0	-0.038	-1000.0
ErbB4 signaling events	11.0	768.0	69.0	-0.207	0.053	1000.0	-1000.0	-0.09	-1000.0
EPHB forward signaling	11.0	941.0	85.0	-0.098	0.084	1000.0	-1000.0	-0.088	-1000.0
EGFR-dependent Endothelin signaling events	11.0	244.0	21.0	-0.098	0.013	1000.0	-1000.0	-0.066	-1000.0
IGF1 pathway	11.0	630.0	57.0	-0.134	0.014	1000.0	-1000.0	-0.087	-1000.0
Rapid glucocorticoid signaling	11.0	227.0	20.0	-0.2	0.013	1000.0	-1000.0	-0.034	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	10.0	371.0	34.0	-0.061	0.013	1000.0	-1000.0	-0.069	-1000.0
Osteopontin-mediated events	10.0	410.0	38.0	-0.106	0.013	1000.0	-1000.0	-0.098	-1000.0
Arf6 signaling events	10.0	657.0	62.0	-0.112	0.013	1000.0	-1000.0	-0.059	-1000.0
S1P5 pathway	10.0	171.0	17.0	-0.085	0.076	1000.0	-1000.0	-0.052	-1000.0
Integrins in angiogenesis	10.0	922.0	84.0	-0.188	0.013	1000.0	-1000.0	-0.095	-1000.0
Nongenotropic Androgen signaling	10.0	567.0	52.0	-0.178	0.021	1000.0	-1000.0	-0.058	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1215.0	120.0	-0.227	0.189	1000.0	-1000.0	-0.074	-1000.0
FOXM1 transcription factor network	10.0	517.0	51.0	-0.318	0.082	1000.0	-1000.0	-0.178	-1000.0
ErbB2/ErbB3 signaling events	9.0	591.0	65.0	-0.152	0.026	1000.0	-1000.0	-0.064	-1000.0
Sphingosine 1-phosphate (S1P) pathway	9.0	267.0	28.0	-0.085	0.013	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	9.0	46.0	5.0	-0.052	-0.017	1000.0	-1000.0	-0.04	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	446.0	46.0	-0.322	0.02	1000.0	-1000.0	-0.062	-1000.0
Nectin adhesion pathway	9.0	622.0	63.0	-0.094	0.013	1000.0	-1000.0	-0.073	-1000.0
Effects of Botulinum toxin	9.0	234.0	26.0	-0.091	0.013	1000.0	-1000.0	-0.061	-1000.0
Ras signaling in the CD4+ TCR pathway	9.0	154.0	17.0	-0.067	0.023	1000.0	-1000.0	-0.043	-1000.0
Visual signal transduction: Cones	8.0	320.0	38.0	-0.082	0.013	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by PTP1B	8.0	645.0	76.0	-0.107	0.018	1000.0	-1000.0	-0.078	-1000.0
S1P1 pathway	8.0	308.0	36.0	-0.086	0.013	1000.0	-1000.0	-0.055	-1000.0
IL2 signaling events mediated by STAT5	8.0	179.0	22.0	-0.15	0.014	1000.0	-1000.0	-0.042	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	270.0	33.0	-0.313	0.037	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	671.0	78.0	-0.082	0.057	1000.0	-1000.0	-0.067	-1000.0
LPA4-mediated signaling events	7.0	90.0	12.0	-0.067	0.017	1000.0	-1000.0	-0.02	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	990.0	136.0	-0.235	0.058	1000.0	-1000.0	-0.068	-1000.0
Ephrin A  reverse signaling	7.0	54.0	7.0	-0.034	-0.0	1000.0	-1000.0	-0.034	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	7.0	381.0	52.0	-0.179	0.042	1000.0	-1000.0	-0.064	-1000.0
FAS signaling pathway (CD95)	7.0	370.0	47.0	-0.218	0.014	1000.0	-1000.0	-0.047	-1000.0
Syndecan-3-mediated signaling events	7.0	265.0	35.0	-0.213	0.013	1000.0	-1000.0	-0.064	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	518.0	74.0	-0.129	0.056	1000.0	-1000.0	-0.089	-1000.0
S1P4 pathway	7.0	181.0	25.0	-0.085	0.013	1000.0	-1000.0	-0.052	-1000.0
Regulation of Androgen receptor activity	7.0	521.0	70.0	-0.381	0.025	1000.0	-1000.0	-0.07	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	367.0	54.0	-0.163	0.027	1000.0	-1000.0	-0.083	-1000.0
PDGFR-alpha signaling pathway	6.0	293.0	44.0	-0.047	0.022	1000.0	-1000.0	-0.064	-1000.0
IL2 signaling events mediated by PI3K	6.0	396.0	58.0	-0.132	0.031	1000.0	-1000.0	-0.078	-1000.0
Plasma membrane estrogen receptor signaling	6.0	601.0	86.0	-0.129	0.016	1000.0	-1000.0	-0.086	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	614.0	88.0	-0.11	0.045	1000.0	-1000.0	-0.122	-1000.0
BARD1 signaling events	5.0	336.0	57.0	-0.043	0.043	1000.0	-1000.0	-0.058	-1000.0
Cellular roles of Anthrax toxin	5.0	201.0	39.0	-0.079	0.018	1000.0	-1000.0	-0.037	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	221.0	37.0	-0.052	0.013	1000.0	-1000.0	-0.055	-1000.0
TRAIL signaling pathway	5.0	272.0	48.0	-0.046	0.03	1000.0	-1000.0	-0.069	-1000.0
Canonical Wnt signaling pathway	5.0	282.0	51.0	-0.122	0.059	1000.0	-1000.0	-0.058	-1000.0
S1P3 pathway	5.0	226.0	42.0	-0.072	0.023	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	5.0	243.0	43.0	-0.055	0.032	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	-0.029	0.013	1000.0	-1000.0	-0.04	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	291.0	65.0	-0.102	0.052	1000.0	-1000.0	-0.064	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	297.0	61.0	-0.122	0.035	1000.0	-1000.0	-0.069	-1000.0
IFN-gamma pathway	4.0	330.0	68.0	-0.088	0.027	1000.0	-1000.0	-0.096	-1000.0
HIF-2-alpha transcription factor network	4.0	214.0	43.0	-0.053	0.059	1000.0	-1000.0	-0.094	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	65.0	15.0	-0.024	0.023	1000.0	-1000.0	-0.033	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	158.0	36.0	-0.052	0.023	1000.0	-1000.0	-0.065	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	219.0	45.0	-0.099	0.034	1000.0	-1000.0	-0.093	-1000.0
Regulation of p38-alpha and p38-beta	4.0	226.0	54.0	-0.076	0.014	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	309.0	76.0	-0.054	0.039	1000.0	-1000.0	-0.08	-1000.0
Class I PI3K signaling events	4.0	360.0	73.0	-0.076	0.035	1000.0	-1000.0	-0.07	-1000.0
Regulation of Telomerase	4.0	492.0	102.0	-0.144	0.043	1000.0	-1000.0	-0.103	-1000.0
Aurora B signaling	4.0	319.0	67.0	-0.187	0.022	1000.0	-1000.0	-0.07	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	323.0	85.0	-0.112	0.019	1000.0	-1000.0	-0.07	-1000.0
EPO signaling pathway	3.0	182.0	55.0	-0.044	0.05	1000.0	-1000.0	-0.089	-1000.0
Ceramide signaling pathway	3.0	260.0	76.0	-0.129	0.023	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class III	3.0	137.0	40.0	-0.118	0.021	1000.0	-1000.0	-0.046	-1000.0
TCGA08_rtk_signaling	3.0	84.0	26.0	-0.055	0.034	1000.0	-1000.0	-0.022	-1000.0
Insulin Pathway	3.0	293.0	74.0	-0.083	0.035	1000.0	-1000.0	-0.083	-1000.0
PDGFR-beta signaling pathway	3.0	380.0	97.0	-0.066	0.055	1000.0	-1000.0	-0.081	-1000.0
Canonical NF-kappaB pathway	2.0	88.0	39.0	-0.051	0.069	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class II	2.0	197.0	75.0	-0.066	0.031	1000.0	-1000.0	-0.061	-1000.0
Aurora C signaling	2.0	16.0	7.0	-0.019	-0.0	1000.0	-1000.0	-0.041	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	236.0	83.0	-0.112	0.043	1000.0	-1000.0	-0.071	-1000.0
Retinoic acid receptors-mediated signaling	2.0	166.0	58.0	-0.042	0.038	1000.0	-1000.0	-0.073	-1000.0
Atypical NF-kappaB pathway	2.0	73.0	31.0	-0.027	0.032	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	277.0	125.0	-0.04	0.074	1000.0	-1000.0	-0.089	-1000.0
VEGFR1 specific signals	2.0	119.0	56.0	-0.033	0.053	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by PRL	2.0	75.0	34.0	-0.086	0.033	1000.0	-1000.0	-0.046	-1000.0
p38 MAPK signaling pathway	2.0	94.0	44.0	-0.078	0.024	1000.0	-1000.0	-0.062	-1000.0
Aurora A signaling	1.0	103.0	60.0	-0.024	0.03	1000.0	-1000.0	-0.056	-1000.0
Arf6 downstream pathway	1.0	55.0	43.0	-0.022	0.025	1000.0	-1000.0	-0.044	-1000.0
PLK1 signaling events	1.0	118.0	85.0	-0.014	0.031	1000.0	-1000.0	-0.045	-1000.0
Insulin-mediated glucose transport	1.0	36.0	32.0	-0.03	0.032	1000.0	-1000.0	-0.071	-1000.0
mTOR signaling pathway	1.0	104.0	53.0	-0.016	0.027	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	1.0	84.0	49.0	-0.054	0.032	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by HDAC Class I	1.0	181.0	104.0	-0.091	0.055	1000.0	-1000.0	-0.064	-1000.0
FoxO family signaling	1.0	72.0	64.0	-0.095	0.136	1000.0	-1000.0	-0.068	-1000.0
Arf6 trafficking events	1.0	97.0	71.0	-0.062	0.044	1000.0	-1000.0	-0.079	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	-0.015	0.046	1000.0	-1000.0	-0.054	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.011	0.021	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	21.0	22.0	-0.023	0.045	1000.0	-1000.0	-0.061	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	45.0	68.0	-0.036	0.049	1000.0	-1000.0	-0.054	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.012	0.033	1000.0	-1000.0	-0.06	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.017	0.028	1000.0	-1000.0	-0.044	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.003	0.013	1000.0	-1000.0	-0.064	-1000.0
Total	1251	71971	7203	-18.4209801243	-1994.2704392	131000	-131000	-8.86093461817	-131000