Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	26.0	1570.0	60.0	-0.629	0.012	1000.0	-1000.0	-0.167	-1000.0
IL4-mediated signaling events	22.0	2030.0	91.0	-0.825	0.7	1000.0	-1000.0	-0.162	-1000.0
HIF-1-alpha transcription factor network	20.0	1592.0	76.0	-0.568	0.019	1000.0	-1000.0	-0.185	-1000.0
p75(NTR)-mediated signaling	19.0	2457.0	125.0	-0.229	0.034	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by the Hedgehog family	17.0	925.0	52.0	-0.267	0.071	1000.0	-1000.0	-0.063	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	752.0	44.0	-0.232	0.012	1000.0	-1000.0	-0.06	-1000.0
BMP receptor signaling	16.0	1363.0	81.0	-0.266	0.025	1000.0	-1000.0	-0.089	-1000.0
Syndecan-1-mediated signaling events	15.0	541.0	34.0	-0.18	0.012	1000.0	-1000.0	-0.056	-1000.0
IL12-mediated signaling events	14.0	1225.0	87.0	-0.314	0.097	1000.0	-1000.0	-0.138	-1000.0
Glypican 1 network	14.0	703.0	48.0	-0.138	0.021	1000.0	-1000.0	-0.047	-1000.0
Glucocorticoid receptor regulatory network	14.0	1700.0	114.0	-0.64	0.31	1000.0	-1000.0	-0.076	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1333.0	93.0	-0.16	0.085	1000.0	-1000.0	-0.083	-1000.0
Glypican 2 network	14.0	58.0	4.0	-0.059	-0.047	1000.0	-1000.0	-0.028	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	605.0	46.0	-0.389	0.019	1000.0	-1000.0	-0.117	-1000.0
Endothelins	13.0	1253.0	96.0	-0.206	0.021	1000.0	-1000.0	-0.088	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	12.0	418.0	34.0	-0.085	0.012	1000.0	-1000.0	-0.053	-1000.0
Wnt signaling	12.0	90.0	7.0	-0.098	0.012	1000.0	-1000.0	-0.031	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1535.0	120.0	-0.282	0.214	1000.0	-1000.0	-0.077	-1000.0
Syndecan-2-mediated signaling events	11.0	792.0	69.0	-0.13	0.017	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	11.0	916.0	82.0	-0.13	0.014	1000.0	-1000.0	-0.077	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	11.0	798.0	68.0	-0.324	0.074	1000.0	-1000.0	-0.13	-1000.0
BCR signaling pathway	11.0	1169.0	99.0	-0.185	0.025	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	11.0	235.0	21.0	-0.105	0.018	1000.0	-1000.0	-0.066	-1000.0
Syndecan-4-mediated signaling events	11.0	739.0	67.0	-0.155	0.023	1000.0	-1000.0	-0.094	-1000.0
Integrins in angiogenesis	10.0	859.0	84.0	-0.185	0.018	1000.0	-1000.0	-0.099	-1000.0
Effects of Botulinum toxin	10.0	282.0	26.0	-0.186	0.012	1000.0	-1000.0	-0.066	-1000.0
Plasma membrane estrogen receptor signaling	10.0	871.0	86.0	-0.115	0.068	1000.0	-1000.0	-0.082	-1000.0
Thromboxane A2 receptor signaling	9.0	970.0	105.0	-0.105	0.025	1000.0	-1000.0	-0.071	-1000.0
Signaling events regulated by Ret tyrosine kinase	9.0	805.0	82.0	-0.125	0.012	1000.0	-1000.0	-0.087	-1000.0
Calcium signaling in the CD4+ TCR pathway	9.0	291.0	31.0	-0.238	0.012	1000.0	-1000.0	-0.093	-1000.0
IL27-mediated signaling events	9.0	496.0	51.0	-0.137	0.076	1000.0	-1000.0	-0.089	-1000.0
IGF1 pathway	9.0	520.0	57.0	-0.118	0.025	1000.0	-1000.0	-0.095	-1000.0
Class IB PI3K non-lipid kinase events	9.0	27.0	3.0	-0.025	-1000.0	1000.0	-1000.0	-0.015	-1000.0
ErbB4 signaling events	8.0	581.0	69.0	-0.186	0.067	1000.0	-1000.0	-0.088	-1000.0
Noncanonical Wnt signaling pathway	8.0	215.0	26.0	-0.098	0.012	1000.0	-1000.0	-0.066	-1000.0
Arf6 signaling events	8.0	548.0	62.0	-0.107	0.021	1000.0	-1000.0	-0.062	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	853.0	97.0	-0.13	0.028	1000.0	-1000.0	-0.083	-1000.0
PDGFR-alpha signaling pathway	8.0	371.0	44.0	-0.084	0.021	1000.0	-1000.0	-0.045	-1000.0
Nectin adhesion pathway	8.0	557.0	63.0	-0.095	0.021	1000.0	-1000.0	-0.07	-1000.0
S1P5 pathway	8.0	141.0	17.0	-0.094	0.069	1000.0	-1000.0	-0.036	-1000.0
Ephrin B reverse signaling	8.0	394.0	48.0	-0.095	0.061	1000.0	-1000.0	-0.068	-1000.0
LPA receptor mediated events	8.0	859.0	102.0	-0.11	0.02	1000.0	-1000.0	-0.082	-1000.0
LPA4-mediated signaling events	7.0	88.0	12.0	-0.073	0.018	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	7.0	586.0	74.0	-0.087	0.031	1000.0	-1000.0	-0.047	-1000.0
Coregulation of Androgen receptor activity	7.0	602.0	76.0	-0.185	0.023	1000.0	-1000.0	-0.04	-1000.0
Ephrin A  reverse signaling	7.0	52.0	7.0	-0.012	-0.0	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PTP1B	7.0	543.0	76.0	-0.187	0.019	1000.0	-1000.0	-0.089	-1000.0
Reelin signaling pathway	7.0	432.0	56.0	-0.173	0.018	1000.0	-1000.0	-0.082	-1000.0
IL1-mediated signaling events	7.0	484.0	62.0	-0.169	0.058	1000.0	-1000.0	-0.094	-1000.0
Canonical Wnt signaling pathway	7.0	364.0	51.0	-0.161	0.067	1000.0	-1000.0	-0.067	-1000.0
EPHB forward signaling	7.0	659.0	85.0	-0.114	0.089	1000.0	-1000.0	-0.093	-1000.0
Nongenotropic Androgen signaling	7.0	398.0	52.0	-0.103	0.015	1000.0	-1000.0	-0.065	-1000.0
Visual signal transduction: Rods	7.0	372.0	52.0	-0.173	0.012	1000.0	-1000.0	-0.084	-1000.0
Osteopontin-mediated events	6.0	246.0	38.0	-0.109	0.012	1000.0	-1000.0	-0.109	-1000.0
Cellular roles of Anthrax toxin	6.0	236.0	39.0	-0.075	0.013	1000.0	-1000.0	-0.026	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	414.0	61.0	-0.161	0.029	1000.0	-1000.0	-0.069	-1000.0
IL6-mediated signaling events	6.0	514.0	75.0	-0.138	0.044	1000.0	-1000.0	-0.099	-1000.0
TCGA08_retinoblastoma	6.0	55.0	8.0	-0.012	0.015	1000.0	-1000.0	-0.025	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	611.0	88.0	-0.142	0.022	1000.0	-1000.0	-0.1	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	152.0	28.0	-0.094	0.031	1000.0	-1000.0	-0.041	-1000.0
Visual signal transduction: Cones	5.0	222.0	38.0	-0.069	0.012	1000.0	-1000.0	-0.062	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	98.0	17.0	-0.041	0.014	1000.0	-1000.0	-0.042	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	325.0	65.0	-0.322	0.037	1000.0	-1000.0	-0.075	-1000.0
TRAIL signaling pathway	5.0	251.0	48.0	-0.038	0.018	1000.0	-1000.0	-0.068	-1000.0
Syndecan-3-mediated signaling events	5.0	201.0	35.0	-0.18	0.034	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by PI3K	5.0	308.0	58.0	-0.068	0.023	1000.0	-1000.0	-0.091	-1000.0
S1P4 pathway	5.0	135.0	25.0	-0.094	0.018	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	461.0	78.0	-0.072	0.043	1000.0	-1000.0	-0.075	-1000.0
Regulation of Androgen receptor activity	5.0	414.0	70.0	-0.268	0.027	1000.0	-1000.0	-0.061	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	90.0	17.0	-0.035	0.02	1000.0	-1000.0	-0.039	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	572.0	136.0	-0.184	0.062	1000.0	-1000.0	-0.067	-1000.0
BARD1 signaling events	4.0	263.0	57.0	-0.041	0.034	1000.0	-1000.0	-0.06	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	349.0	85.0	-0.051	0.018	1000.0	-1000.0	-0.075	-1000.0
IFN-gamma pathway	4.0	311.0	68.0	-0.132	0.02	1000.0	-1000.0	-0.103	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	63.0	15.0	-0.015	0.024	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by STAT5	4.0	102.0	22.0	-0.048	0.021	1000.0	-1000.0	-0.061	-1000.0
Regulation of Telomerase	4.0	474.0	102.0	-0.134	0.037	1000.0	-1000.0	-0.109	-1000.0
S1P3 pathway	4.0	177.0	42.0	-0.065	0.023	1000.0	-1000.0	-0.039	-1000.0
ErbB2/ErbB3 signaling events	3.0	200.0	65.0	-0.106	0.021	1000.0	-1000.0	-0.074	-1000.0
a4b1 and a4b7 Integrin signaling	3.0	18.0	5.0	-0.005	0.005	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	3.0	266.0	76.0	-0.115	0.034	1000.0	-1000.0	-0.054	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	146.0	37.0	-0.053	0.021	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	3.0	141.0	40.0	-0.168	0.021	1000.0	-1000.0	-0.039	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	202.0	52.0	-0.099	0.039	1000.0	-1000.0	-0.051	-1000.0
S1P1 pathway	3.0	135.0	36.0	-0.098	0.012	1000.0	-1000.0	-0.067	-1000.0
FAS signaling pathway (CD95)	3.0	163.0	47.0	-0.059	0.015	1000.0	-1000.0	-0.045	-1000.0
Retinoic acid receptors-mediated signaling	3.0	214.0	58.0	-0.082	0.025	1000.0	-1000.0	-0.079	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	146.0	45.0	-0.067	0.037	1000.0	-1000.0	-0.088	-1000.0
Class I PI3K signaling events	3.0	257.0	73.0	-0.088	0.026	1000.0	-1000.0	-0.063	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	106.0	33.0	-0.113	0.032	1000.0	-1000.0	-0.054	-1000.0
Rapid glucocorticoid signaling	3.0	72.0	20.0	-0.045	0.014	1000.0	-1000.0	-0.026	-1000.0
p38 MAPK signaling pathway	3.0	146.0	44.0	-0.128	0.023	1000.0	-1000.0	-0.065	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	-0.003	0.012	1000.0	-1000.0	-0.02	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	151.0	54.0	-0.073	0.024	1000.0	-1000.0	-0.107	-1000.0
Aurora A signaling	2.0	141.0	60.0	-0.149	0.036	1000.0	-1000.0	-0.055	-1000.0
EPO signaling pathway	2.0	117.0	55.0	-0.031	0.042	1000.0	-1000.0	-0.095	-1000.0
mTOR signaling pathway	2.0	112.0	53.0	-0.019	0.02	1000.0	-1000.0	-0.062	-1000.0
TCGA08_p53	2.0	15.0	7.0	-0.01	0.012	1000.0	-1000.0	-0.016	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	72.0	36.0	-0.053	0.027	1000.0	-1000.0	-0.071	-1000.0
Regulation of p38-alpha and p38-beta	2.0	131.0	54.0	-0.088	0.031	1000.0	-1000.0	-0.063	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	331.0	125.0	-0.07	0.043	1000.0	-1000.0	-0.097	-1000.0
TCGA08_rtk_signaling	2.0	65.0	26.0	-0.038	0.037	1000.0	-1000.0	-0.023	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	214.0	74.0	-0.19	0.062	1000.0	-1000.0	-0.088	-1000.0
Insulin Pathway	2.0	174.0	74.0	-0.142	0.031	1000.0	-1000.0	-0.093	-1000.0
VEGFR1 specific signals	2.0	126.0	56.0	-0.026	0.034	1000.0	-1000.0	-0.056	-1000.0
PDGFR-beta signaling pathway	2.0	260.0	97.0	-0.061	0.034	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by PRL	2.0	78.0	34.0	-0.094	0.031	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	2.0	115.0	51.0	-0.096	0.124	1000.0	-1000.0	-0.19	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	27.0	23.0	-0.032	0.038	1000.0	-1000.0	-0.052	-1000.0
Canonical NF-kappaB pathway	1.0	55.0	39.0	-0.04	0.063	1000.0	-1000.0	-0.085	-1000.0
Signaling events mediated by HDAC Class II	1.0	123.0	75.0	-0.073	0.032	1000.0	-1000.0	-0.043	-1000.0
Circadian rhythm pathway	1.0	28.0	22.0	-0.02	0.039	1000.0	-1000.0	-0.051	-1000.0
Arf6 downstream pathway	1.0	66.0	43.0	-0.022	0.025	1000.0	-1000.0	-0.032	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.003	0.014	1000.0	-1000.0	-0.024	-1000.0
Insulin-mediated glucose transport	1.0	44.0	32.0	-0.037	0.043	1000.0	-1000.0	-0.062	-1000.0
ceramide signaling pathway	1.0	80.0	49.0	-0.04	0.029	1000.0	-1000.0	-0.056	-1000.0
HIF-2-alpha transcription factor network	1.0	54.0	43.0	-0.075	0.077	1000.0	-1000.0	-0.099	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	145.0	83.0	-0.072	0.05	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by HDAC Class I	1.0	110.0	104.0	-0.04	0.048	1000.0	-1000.0	-0.061	-1000.0
FoxO family signaling	1.0	64.0	64.0	-0.061	0.123	1000.0	-1000.0	-0.071	-1000.0
Atypical NF-kappaB pathway	1.0	42.0	31.0	-0.019	0.04	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	83.0	76.0	-0.031	0.052	1000.0	-1000.0	-0.086	-1000.0
Arf6 trafficking events	1.0	71.0	71.0	-0.031	0.039	1000.0	-1000.0	-0.074	-1000.0
E-cadherin signaling in keratinocytes	1.0	70.0	43.0	-0.031	0.035	1000.0	-1000.0	-0.065	-1000.0
Aurora B signaling	1.0	83.0	67.0	-0.08	0.033	1000.0	-1000.0	-0.065	-1000.0
PLK1 signaling events	0.0	53.0	85.0	-0.013	0.029	1000.0	-1000.0	-0.039	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	36.0	68.0	-0.037	0.044	1000.0	-1000.0	-0.056	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.0	0.03	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.025	1000.0	-1000.0	-0.025	-1000.0
Arf1 pathway	0.0	21.0	54.0	-0.017	0.025	1000.0	-1000.0	-0.035	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.034	1000.0	-1000.0	-0.038	-1000.0
Total	797	51654	7203	-15.9881829741	-994.734685209	131000	-131000	-8.98584200382	-131000