Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	52.0	423.0	8.0	-0.183	0.112	1000.0	-1000.0	-0.015	-1000.0
Syndecan-1-mediated signaling events	31.0	1071.0	34.0	-0.309	0.013	1000.0	-1000.0	-0.045	-1000.0
Ephrin A  reverse signaling	25.0	175.0	7.0	-0.068	-0.0	1000.0	-1000.0	-0.023	-1000.0
IL23-mediated signaling events	25.0	1546.0	60.0	-0.539	0.013	1000.0	-1000.0	-0.167	-1000.0
Signaling events regulated by Ret tyrosine kinase	22.0	1880.0	82.0	-0.238	0.013	1000.0	-1000.0	-0.08	-1000.0
TCGA08_p53	22.0	157.0	7.0	-0.129	0.042	1000.0	-1000.0	-0.01	-1000.0
EGFR-dependent Endothelin signaling events	21.0	449.0	21.0	-0.226	0.019	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by the Hedgehog family	20.0	1054.0	52.0	-0.179	0.144	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	19.0	1672.0	87.0	-0.414	0.064	1000.0	-1000.0	-0.127	-1000.0
PDGFR-alpha signaling pathway	18.0	810.0	44.0	-0.101	0.023	1000.0	-1000.0	-0.054	-1000.0
TCR signaling in naïve CD8+ T cells	18.0	1723.0	93.0	-0.191	0.039	1000.0	-1000.0	-0.072	-1000.0
Glypican 2 network	18.0	75.0	4.0	-0.062	-0.047	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling events	18.0	94.0	5.0	-0.111	0.013	1000.0	-1000.0	-0.027	-1000.0
Glypican 1 network	17.0	836.0	48.0	-0.258	0.03	1000.0	-1000.0	-0.03	-1000.0
Reelin signaling pathway	17.0	980.0	56.0	-0.254	0.03	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	763.0	44.0	-0.177	0.013	1000.0	-1000.0	-0.044	-1000.0
Arf6 signaling events	16.0	1008.0	62.0	-0.226	0.023	1000.0	-1000.0	-0.049	-1000.0
IL4-mediated signaling events	16.0	1533.0	91.0	-0.549	0.416	1000.0	-1000.0	-0.14	-1000.0
Effects of Botulinum toxin	16.0	431.0	26.0	-0.177	0.013	1000.0	-1000.0	-0.063	-1000.0
Angiopoietin receptor Tie2-mediated signaling	16.0	1432.0	88.0	-0.204	0.031	1000.0	-1000.0	-0.106	-1000.0
Syndecan-4-mediated signaling events	15.0	1047.0	67.0	-0.196	0.023	1000.0	-1000.0	-0.09	-1000.0
Visual signal transduction: Cones	14.0	562.0	38.0	-0.136	0.013	1000.0	-1000.0	-0.052	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	14.0	1258.0	85.0	-0.161	0.013	1000.0	-1000.0	-0.073	-1000.0
HIF-1-alpha transcription factor network	13.0	1026.0	76.0	-0.252	0.043	1000.0	-1000.0	-0.136	-1000.0
p75(NTR)-mediated signaling	13.0	1637.0	125.0	-0.207	0.038	1000.0	-1000.0	-0.091	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	640.0	46.0	-0.428	0.016	1000.0	-1000.0	-0.1	-1000.0
Endothelins	13.0	1308.0	96.0	-0.211	0.029	1000.0	-1000.0	-0.074	-1000.0
ErbB2/ErbB3 signaling events	12.0	781.0	65.0	-0.179	0.019	1000.0	-1000.0	-0.056	-1000.0
Caspase cascade in apoptosis	12.0	932.0	74.0	-0.177	0.054	1000.0	-1000.0	-0.041	-1000.0
amb2 Integrin signaling	12.0	1004.0	82.0	-0.213	0.014	1000.0	-1000.0	-0.067	-1000.0
Glucocorticoid receptor regulatory network	12.0	1468.0	114.0	-0.45	0.282	1000.0	-1000.0	-0.066	-1000.0
Thromboxane A2 receptor signaling	11.0	1231.0	105.0	-0.226	0.027	1000.0	-1000.0	-0.055	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	11.0	791.0	68.0	-0.376	0.033	1000.0	-1000.0	-0.114	-1000.0
Visual signal transduction: Rods	11.0	599.0	52.0	-0.146	0.013	1000.0	-1000.0	-0.079	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	319.0	31.0	-0.238	0.013	1000.0	-1000.0	-0.081	-1000.0
Wnt signaling	10.0	71.0	7.0	-0.069	0.002	1000.0	-1000.0	-0.025	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	493.0	54.0	-0.181	0.026	1000.0	-1000.0	-0.088	-1000.0
Noncanonical Wnt signaling pathway	9.0	246.0	26.0	-0.089	0.013	1000.0	-1000.0	-0.047	-1000.0
Syndecan-2-mediated signaling events	9.0	627.0	69.0	-0.175	0.025	1000.0	-1000.0	-0.03	-1000.0
BMP receptor signaling	9.0	749.0	81.0	-0.179	0.029	1000.0	-1000.0	-0.082	-1000.0
IL1-mediated signaling events	9.0	609.0	62.0	-0.157	0.041	1000.0	-1000.0	-0.088	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	9.0	496.0	52.0	-0.147	0.03	1000.0	-1000.0	-0.047	-1000.0
Retinoic acid receptors-mediated signaling	9.0	527.0	58.0	-0.154	0.026	1000.0	-1000.0	-0.063	-1000.0
Syndecan-3-mediated signaling events	9.0	334.0	35.0	-0.226	0.038	1000.0	-1000.0	-0.047	-1000.0
TCGA08_rtk_signaling	9.0	247.0	26.0	-0.226	0.016	1000.0	-1000.0	-0.019	-1000.0
IL2 signaling events mediated by STAT5	9.0	200.0	22.0	-0.195	0.014	1000.0	-1000.0	-0.046	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1168.0	120.0	-0.197	0.071	1000.0	-1000.0	-0.065	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	8.0	284.0	34.0	-0.045	0.013	1000.0	-1000.0	-0.044	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	40.0	5.0	-0.027	-0.002	1000.0	-1000.0	-0.021	-1000.0
Fc-epsilon receptor I signaling in mast cells	8.0	783.0	97.0	-0.181	0.038	1000.0	-1000.0	-0.072	-1000.0
Integrins in angiogenesis	8.0	697.0	84.0	-0.164	0.031	1000.0	-1000.0	-0.078	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	621.0	76.0	-0.111	0.023	1000.0	-1000.0	-0.086	-1000.0
LPA4-mediated signaling events	7.0	88.0	12.0	-0.039	0.016	1000.0	-1000.0	-0.022	-1000.0
ErbB4 signaling events	7.0	518.0	69.0	-0.226	0.077	1000.0	-1000.0	-0.088	-1000.0
Osteopontin-mediated events	7.0	273.0	38.0	-0.064	0.016	1000.0	-1000.0	-0.095	-1000.0
S1P1 pathway	7.0	259.0	36.0	-0.09	0.013	1000.0	-1000.0	-0.055	-1000.0
EPHB forward signaling	7.0	630.0	85.0	-0.125	0.069	1000.0	-1000.0	-0.076	-1000.0
Nongenotropic Androgen signaling	7.0	383.0	52.0	-0.056	0.013	1000.0	-1000.0	-0.055	-1000.0
LPA receptor mediated events	7.0	720.0	102.0	-0.226	0.028	1000.0	-1000.0	-0.077	-1000.0
IL6-mediated signaling events	7.0	579.0	75.0	-0.165	0.048	1000.0	-1000.0	-0.089	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	7.0	557.0	74.0	-0.226	0.06	1000.0	-1000.0	-0.087	-1000.0
FOXM1 transcription factor network	7.0	382.0	51.0	-0.185	0.105	1000.0	-1000.0	-0.173	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	609.0	78.0	-0.073	0.034	1000.0	-1000.0	-0.079	-1000.0
Coregulation of Androgen receptor activity	6.0	506.0	76.0	-0.18	0.025	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PTP1B	6.0	474.0	76.0	-0.227	0.019	1000.0	-1000.0	-0.073	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	424.0	61.0	-0.22	0.039	1000.0	-1000.0	-0.076	-1000.0
Nectin adhesion pathway	6.0	432.0	63.0	-0.111	0.021	1000.0	-1000.0	-0.069	-1000.0
FAS signaling pathway (CD95)	6.0	305.0	47.0	-0.201	0.015	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	6.0	391.0	58.0	-0.186	0.025	1000.0	-1000.0	-0.083	-1000.0
Canonical Wnt signaling pathway	6.0	350.0	51.0	-0.22	0.084	1000.0	-1000.0	-0.046	-1000.0
BCR signaling pathway	6.0	687.0	99.0	-0.135	0.033	1000.0	-1000.0	-0.083	-1000.0
Plasma membrane estrogen receptor signaling	6.0	557.0	86.0	-0.094	0.035	1000.0	-1000.0	-0.079	-1000.0
Rapid glucocorticoid signaling	6.0	131.0	20.0	-0.083	0.014	1000.0	-1000.0	-0.023	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	713.0	136.0	-0.16	0.157	1000.0	-1000.0	-0.061	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	88.0	17.0	-0.052	0.013	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	5.0	35.0	7.0	-0.018	0.0	1000.0	-1000.0	-0.028	-1000.0
Ceramide signaling pathway	5.0	451.0	76.0	-0.114	0.022	1000.0	-1000.0	-0.041	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	5.0	221.0	37.0	-0.064	0.019	1000.0	-1000.0	-0.052	-1000.0
S1P5 pathway	5.0	98.0	17.0	-0.057	0.04	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	5.0	229.0	43.0	-0.066	0.028	1000.0	-1000.0	-0.072	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	235.0	45.0	-0.09	0.024	1000.0	-1000.0	-0.086	-1000.0
IL27-mediated signaling events	5.0	264.0	51.0	-0.15	0.014	1000.0	-1000.0	-0.074	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	5.0	173.0	33.0	-0.18	0.035	1000.0	-1000.0	-0.043	-1000.0
E-cadherin signaling in keratinocytes	5.0	256.0	43.0	-0.226	0.015	1000.0	-1000.0	-0.064	-1000.0
Regulation of Androgen receptor activity	5.0	385.0	70.0	-0.273	0.036	1000.0	-1000.0	-0.057	-1000.0
Aurora B signaling	5.0	369.0	67.0	-0.146	0.013	1000.0	-1000.0	-0.073	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.001	0.006	1000.0	-1000.0	-0.018	-1000.0
TRAIL signaling pathway	4.0	232.0	48.0	-0.042	0.024	1000.0	-1000.0	-0.071	-1000.0
ceramide signaling pathway	4.0	221.0	49.0	-0.114	0.017	1000.0	-1000.0	-0.043	-1000.0
Ephrin B reverse signaling	4.0	195.0	48.0	-0.126	0.062	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	588.0	125.0	-0.071	0.023	1000.0	-1000.0	-0.079	-1000.0
Regulation of Telomerase	4.0	461.0	102.0	-0.227	0.043	1000.0	-1000.0	-0.101	-1000.0
IGF1 pathway	4.0	231.0	57.0	-0.033	0.027	1000.0	-1000.0	-0.084	-1000.0
S1P4 pathway	4.0	108.0	25.0	-0.057	0.022	1000.0	-1000.0	-0.04	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	100.0	28.0	-0.057	0.026	1000.0	-1000.0	-0.034	-1000.0
Cellular roles of Anthrax toxin	3.0	137.0	39.0	-0.082	0.017	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	3.0	205.0	65.0	-0.068	0.055	1000.0	-1000.0	-0.057	-1000.0
EPO signaling pathway	3.0	175.0	55.0	-0.075	0.044	1000.0	-1000.0	-0.093	-1000.0
Insulin-mediated glucose transport	3.0	114.0	32.0	-0.082	0.029	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class III	3.0	138.0	40.0	-0.071	0.024	1000.0	-1000.0	-0.033	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	277.0	83.0	-0.153	0.034	1000.0	-1000.0	-0.062	-1000.0
Atypical NF-kappaB pathway	3.0	97.0	31.0	-0.073	0.026	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	3.0	206.0	54.0	-0.156	0.033	1000.0	-1000.0	-0.052	-1000.0
VEGFR1 specific signals	3.0	200.0	56.0	-0.071	0.033	1000.0	-1000.0	-0.046	-1000.0
S1P3 pathway	3.0	149.0	42.0	-0.068	0.02	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.002	0.002	1000.0	-1000.0	-0.012	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	64.0	17.0	-0.03	0.025	1000.0	-1000.0	-0.043	-1000.0
Canonical NF-kappaB pathway	2.0	79.0	39.0	-0.082	0.071	1000.0	-1000.0	-0.079	-1000.0
PLK1 signaling events	2.0	252.0	85.0	-0.042	0.027	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	35.0	15.0	-0.002	0.028	1000.0	-1000.0	-0.026	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	77.0	36.0	-0.037	0.026	1000.0	-1000.0	-0.069	-1000.0
Class I PI3K signaling events	2.0	158.0	73.0	-0.073	0.037	1000.0	-1000.0	-0.057	-1000.0
Insulin Pathway	2.0	206.0	74.0	-0.086	0.033	1000.0	-1000.0	-0.084	-1000.0
p38 MAPK signaling pathway	2.0	125.0	44.0	-0.063	0.025	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class II	1.0	83.0	75.0	-0.039	0.036	1000.0	-1000.0	-0.04	-1000.0
BARD1 signaling events	1.0	67.0	57.0	-0.023	0.054	1000.0	-1000.0	-0.056	-1000.0
Circadian rhythm pathway	1.0	42.0	22.0	-0.011	0.04	1000.0	-1000.0	-0.049	-1000.0
Aurora A signaling	1.0	85.0	60.0	-0.023	0.036	1000.0	-1000.0	-0.037	-1000.0
Arf6 downstream pathway	1.0	56.0	43.0	-0.025	0.025	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	1.0	71.0	53.0	-0.013	0.026	1000.0	-1000.0	-0.059	-1000.0
IFN-gamma pathway	1.0	129.0	68.0	-0.136	0.069	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by HDAC Class I	1.0	136.0	104.0	-0.082	0.049	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	1.0	80.0	64.0	-0.082	0.094	1000.0	-1000.0	-0.071	-1000.0
Arf6 trafficking events	1.0	87.0	71.0	-0.1	0.039	1000.0	-1000.0	-0.068	-1000.0
PDGFR-beta signaling pathway	1.0	187.0	97.0	-0.064	0.053	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by PRL	1.0	50.0	34.0	-0.01	0.024	1000.0	-1000.0	-0.042	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	19.0	23.0	-0.027	0.04	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	57.0	68.0	-0.082	0.046	1000.0	-1000.0	-0.039	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.023	0.032	1000.0	-1000.0	-0.05	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.003	0.032	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.038	1000.0	-1000.0	-0.028	-1000.0
Total	1058	59695	7203	-18.2227415593	4.84435917582	131000	-131000	-7.99092185368	-131000