rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(2), CDC27(3), CUL1(3), CUL2(1), CUL3(5), FBXW11(1), FBXW7(1), FZR1(4), SKP2(1), SMURF2(3), TCEB1(4), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D3(1), UBE2E2(1), VHL(233), WWP2(2) 25294181 284 241 183 21 12 16 29 88 138 1 1.11e-07 <1.00e-15 <3.08e-13 2 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), COPS5(1), EP300(6), HIF1A(3), JUN(2), NOS3(2), VHL(233) 10473682 251 228 153 15 10 11 29 71 129 1 1.12e-08 <1.00e-15 <3.08e-13 3 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), FLT1(4), FLT4(6), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3CA(12), PIK3R1(2), PTK2(1), SHC1(2), VHL(233) 21044758 280 238 179 21 15 20 30 81 133 1 1.78e-08 1.89e-15 3.88e-13 4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(3), AKT3(2), GRB2(1), ILK(1), MAPK3(1), PDK1(1), PIK3CA(12), PTEN(20), PTK2B(2), RBL2(2), SHC1(2), SOS1(6) 12480838 55 50 52 3 3 13 5 17 16 1 0.000257 8.50e-08 1.31e-05 5 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(1), HRAS(1), NGFR(1), NTRK1(4), PIK3CA(12), SHC1(2), SOS1(6) 9746239 36 35 33 1 1 11 5 17 2 0 0.000274 1.70e-05 0.00209 6 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RAC1(1), WASL(6) 8358184 33 32 30 2 0 9 3 17 4 0 0.00810 8.07e-05 0.00829 7 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), GRB2(1), ILK(1), ITGB1(3), MAPK3(1), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), SHC1(2), SOS1(6) 11771993 55 50 52 6 3 11 4 19 17 1 0.0177 0.000129 0.0114 8 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(2), HLA-DRA(1), HLA-DRB1(12) 1276465 16 13 14 3 4 1 3 6 2 0 0.297 0.000216 0.0167 9 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(2), ATM(15), CDKN1A(1), CSNK1A1(1), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(10) 12308769 39 35 39 2 2 5 7 13 12 0 0.00367 0.00208 0.143 10 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(1), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1), TSC1(2), TSC2(5) 17176831 59 55 56 6 2 10 5 21 20 1 0.00631 0.00971 0.598 11 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4E(1), INPPL1(2), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1) 12147172 45 43 42 5 1 9 2 13 19 1 0.0238 0.0119 0.664 12 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(5), GRB2(1), GSK3A(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(12), PPP1R13B(3), PTEN(20), RPS6KA1(2), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), TEC(5), YWHAE(1) 22183202 76 67 73 9 4 15 6 27 23 1 0.00728 0.0133 0.669 13 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(3), MYC(1), SP3(1), TP53(10), WT1(3) 4260168 20 18 20 3 2 2 2 10 4 0 0.246 0.0147 0.669 14 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(2), HLA-DRA(1), HLA-DRB1(12), IL4(1) 2269336 17 14 15 4 4 1 4 6 2 0 0.387 0.0152 0.669 15 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), HLA-DRB1(12), IL3(1) 1672187 14 11 12 3 3 0 3 6 2 0 0.451 0.0166 0.682 16 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(6), GLS(4), GOT1(3) 4816366 15 15 15 1 0 2 1 8 4 0 0.180 0.0218 0.805 17 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(3), GOT2(2), TYR(3) 2929848 10 10 10 1 0 0 3 2 5 0 0.444 0.0222 0.805 18 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(1), PDXP(1), PSAT1(1) 2946049 10 10 10 0 1 1 0 6 2 0 0.144 0.0240 0.821 19 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(3), AKT3(2), BRD4(6), CAP1(1), CBL(1), CDC42(1), CDKN2A(5), F2RL2(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), LNPEP(3), MAPK3(1), PARD3(2), PARD6A(2), PDK1(1), PIK3CA(12), PIK3R1(2), PPYR1(2), PTEN(20), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(1), YWHAE(1) 35289010 92 84 87 8 8 15 10 31 27 1 0.000214 0.0302 0.978 20 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(3), CD28(1), CD3E(2), CD3G(1), CD4(2) 2024848 9 7 8 0 1 2 1 5 0 0 0.0704 0.0344 0.987 21 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(5), E2F1(1), MYC(1), PIK3CA(12), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1C(3), RAC1(1), RB1(1), TP53(10) 12131686 45 41 41 5 4 12 4 18 7 0 0.00904 0.0364 0.987 22 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), CHUK(1), GHR(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1) 8733545 21 21 18 0 0 9 2 7 3 0 0.00147 0.0365 0.987 23 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(4), EGFR(7), HGS(2), RAB5A(1) 7898260 19 19 18 0 3 1 5 5 5 0 0.0101 0.0375 0.987 24 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(5), STAT1(4) 5136758 16 16 16 2 1 0 1 10 4 0 0.398 0.0384 0.987 25 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(1), MPST(2) 4180017 14 14 14 2 1 0 2 6 5 0 0.471 0.0460 1.000 26 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(3), TYR(3) 5954630 15 15 15 1 1 2 5 5 2 0 0.0766 0.0500 1.000 27 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(7), ERBB3(3), NRG1(4), UBE2D1(2) 6368227 20 20 19 3 2 1 4 8 5 0 0.241 0.0679 1.000 28 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), EIF2S2(1), MAP3K14(1), NFKB1(1), RELA(1), TP53(10) 6262124 17 16 17 2 2 5 2 4 4 0 0.135 0.0695 1.000 29 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(2), HLA-DRA(1), HLA-DRB1(12), IL4(1) 3130229 16 13 14 4 3 1 4 6 2 0 0.484 0.0818 1.000 30 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 2522169 9 9 9 2 0 1 3 2 3 0 0.523 0.0869 1.000 31 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(3), GOT2(2) 1638319 5 5 5 1 0 0 2 0 3 0 0.685 0.103 1.000 32 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(4), FUT1(1), GCNT2(4), ST8SIA1(2) 3625939 11 11 9 2 1 1 1 3 5 0 0.593 0.105 1.000 33 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NNMT(1), NNT(6), NT5M(2), QPRT(1) 8974205 20 20 20 1 0 3 3 12 2 0 0.0354 0.130 1.000 34 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(4) 3264531 10 10 10 2 1 1 1 4 3 0 0.529 0.130 1.000 35 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(3), AASDHPPT(2), AASS(4), KARS(1) 4362596 10 10 10 1 0 2 0 3 5 0 0.418 0.156 1.000 36 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 724975 3 2 3 0 0 1 1 1 0 0 0.376 0.166 1.000 37 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(4), GNB1(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1) 9330868 22 22 22 2 2 2 1 14 3 0 0.126 0.170 1.000 38 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(4), KARS(1) 2965715 7 7 7 1 0 1 0 2 4 0 0.574 0.173 1.000 39 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(2), NDUFA13(2) 2543806 6 6 6 0 2 1 0 2 1 0 0.182 0.186 1.000 40 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(4), FUT1(1), FUT6(3), ST3GAL3(1) 2904083 9 9 6 2 2 0 0 0 7 0 0.905 0.196 1.000 41 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2) 3715075 12 11 12 2 1 3 1 6 1 0 0.241 0.199 1.000 42 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1) 6208875 13 13 13 1 2 2 2 7 0 0 0.107 0.206 1.000 43 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), JUN(2), MAPK3(1), POLR2A(6), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 7845704 19 18 19 2 4 2 2 9 2 0 0.0923 0.207 1.000 44 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1), TOB1(2), TOB2(3) 6625463 17 16 17 2 1 3 4 7 2 0 0.167 0.212 1.000 45 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(2), CD3G(1), CD86(1), GRB2(1), HLA-DRA(1), HLA-DRB1(12), ITK(1), PIK3CA(12), PIK3R1(2), PTPN11(1) 7740259 35 30 30 6 4 9 6 12 4 0 0.103 0.233 1.000 46 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(6) 5348304 11 11 11 1 0 0 4 6 1 0 0.206 0.244 1.000 47 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), IDS(2), IDUA(1), LCT(2) 8830693 22 18 20 2 4 2 4 10 2 0 0.0329 0.248 1.000 48 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(3), AOC3(1), CES1(2) 3505264 11 10 11 2 0 2 2 6 1 0 0.360 0.250 1.000 49 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(3), HADHA(1) 3042194 6 6 6 0 1 2 1 1 1 0 0.153 0.258 1.000 50 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(5), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(3), SRC(2) 12092696 35 33 33 5 1 6 4 16 8 0 0.124 0.269 1.000 51 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD3E(2), CD3G(1), CD4(2), IL3(1), KITLG(2) 3881708 9 8 9 1 0 2 1 5 1 0 0.349 0.271 1.000 52 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(1) 7386124 14 13 14 1 2 4 3 2 3 0 0.0801 0.273 1.000 53 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ACADS(2), ECHS1(2), HADHA(1) 3351862 6 6 5 0 3 0 2 1 0 0 0.105 0.277 1.000 54 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(9), ARHGDIB(1), CASP1(1), CASP10(3), JUN(2), PRF1(1) 7740063 17 15 15 2 0 4 2 7 3 1 0.188 0.282 1.000 55 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 450414 1 1 1 0 0 0 1 0 0 0 0.751 0.285 1.000 56 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HBXIP(1), HRAS(1), PTK2B(2), SHC1(2), SOS1(6), SRC(2) 5343368 15 15 15 3 1 6 2 6 0 0 0.277 0.287 1.000 57 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), CD4(2), FYN(1), HLA-DRA(1), HLA-DRB1(12), PTPRC(6) 5358108 25 20 23 5 3 2 4 13 3 0 0.348 0.291 1.000 58 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(4), PRODH(1) 3471066 7 7 7 1 0 1 2 3 1 0 0.433 0.301 1.000 59 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(2) 2752495 6 6 6 0 0 1 0 5 0 0 0.272 0.305 1.000 60 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(4), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), FUT1(1), FUT6(3), GCNT2(4), ST3GAL6(1), ST8SIA1(2) 9346872 22 21 19 3 2 3 3 5 9 0 0.291 0.320 1.000 61 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(12), MAP2(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1), PRKCE(4) 11238170 27 25 26 3 4 1 0 15 7 0 0.232 0.321 1.000 62 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), SPAM1(4) 12652402 34 27 32 4 6 5 5 15 3 0 0.0155 0.322 1.000 63 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), GOT1(3), GOT2(2), PAH(3), YARS(1) 5167192 12 12 12 2 0 0 4 4 4 0 0.457 0.324 1.000 64 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 9796405 19 19 19 1 3 0 0 12 4 0 0.0483 0.333 1.000 65 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(12), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6) 13758110 46 36 44 6 5 5 5 27 4 0 0.0545 0.335 1.000 66 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(12), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6) 13758110 46 36 44 6 5 5 5 27 4 0 0.0545 0.335 1.000 67 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(7), MAP3K1(5), MAPK14(1), NCOR2(4), RARA(4), THRA(2) 10677896 27 27 26 4 1 3 7 9 7 0 0.138 0.340 1.000 68 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), STX1A(1) 1996435 4 4 4 1 0 0 0 2 2 0 0.856 0.348 1.000 69 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(1), RDH11(3) 2927708 6 6 6 1 1 0 1 4 0 0 0.463 0.352 1.000 70 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(1), IL4(1), JUN(2), MAP3K1(5), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(1), TNFRSF9(1), TNFSF9(1) 12202915 24 23 24 2 0 3 1 14 6 0 0.151 0.361 1.000 71 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1) 6501222 12 12 12 1 1 1 1 5 4 0 0.250 0.363 1.000 72 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAP2B(2) 8918662 21 21 21 3 2 1 2 11 5 0 0.363 0.366 1.000 73 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(1), IL4(1), IL4R(2), IRS1(3), JAK1(4), JAK3(4), RPS6KB1(1), SHC1(2), STAT6(4) 8845567 24 24 23 4 3 3 2 9 7 0 0.271 0.369 1.000 74 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RALBP1(1), RELA(1) 11917286 25 25 22 3 1 10 2 9 3 0 0.0590 0.388 1.000 75 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(2), LUM(1) 2235482 6 6 6 2 0 1 0 4 1 0 0.681 0.389 1.000 76 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(3), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(20), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), RPS6KB1(1) 17233400 77 71 68 13 5 16 6 27 22 1 0.0545 0.396 1.000 77 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(1), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(3) 7260897 18 18 18 3 1 3 4 7 3 0 0.240 0.397 1.000 78 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 1069531 2 2 2 0 0 1 0 1 0 0 0.498 0.408 1.000 79 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(1), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(6) 17831564 48 47 45 7 4 10 4 27 3 0 0.0559 0.427 1.000 80 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(4), HRAS(1), PAX3(1), PML(3), RARA(4), RB1(1), SIRT1(4), SP100(1), TNFRSF1A(1), TP53(10) 11424579 34 31 34 5 3 5 7 15 4 0 0.0744 0.436 1.000 81 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(4), MMP9(1), RECK(1) 4647674 8 8 8 1 0 2 1 3 2 0 0.375 0.438 1.000 82 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(4) 7072431 19 17 19 3 1 0 1 13 4 0 0.445 0.443 1.000 83 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(15), ATR(5), CDC25C(2), CHEK2(3), TP53(10) 9985565 35 30 34 5 2 3 7 13 10 0 0.160 0.461 1.000 84 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAP3K1(5), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), SOS1(6), STAT1(4), STAT5B(1) 16989027 44 42 41 6 2 9 4 25 4 0 0.0418 0.464 1.000 85 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(3), TPI1(1) 2389282 6 6 6 4 0 0 1 1 4 0 0.993 0.471 1.000 86 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), RAC1(1), WASL(6) 5054098 11 11 11 2 0 3 0 8 0 0 0.439 0.473 1.000 87 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(6), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(2), GJA1(2), GNAI1(1), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2) 18561496 42 42 38 5 2 12 6 16 6 0 0.00712 0.475 1.000 88 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(2), CD3G(1), CD4(2), ITGAL(4), ITGB2(1), PTPRC(6) 6984514 17 15 17 3 2 3 2 9 1 0 0.253 0.475 1.000 89 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(3), HADHA(1), HADHB(2) 5239709 8 8 8 0 1 3 2 1 1 0 0.0751 0.477 1.000 90 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(1), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(3) 7138474 17 17 17 3 1 3 3 7 3 0 0.287 0.477 1.000 91 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2) 3885215 10 10 10 2 0 1 0 8 1 0 0.676 0.479 1.000 92 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), MST1(1), MST1R(4) 3737496 6 6 5 1 0 0 4 1 1 0 0.523 0.495 1.000 93 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), UGP2(1), UXS1(1) 3135576 5 5 5 1 0 0 3 2 0 0 0.562 0.513 1.000 94 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(2), SYT1(1) 7152685 12 12 12 0 1 1 1 7 2 0 0.0891 0.514 1.000 95 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), UXS1(1) 2482167 4 4 4 1 0 0 2 2 0 0 0.701 0.516 1.000 96 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(4), GNB1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 5851185 15 15 15 3 2 1 0 11 1 0 0.564 0.524 1.000 97 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(6), NCOA3(5), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RARA(4) 12711401 28 28 28 4 2 1 7 17 1 0 0.0971 0.529 1.000 98 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1B(1), BMPR2(4) 3811083 7 6 7 0 0 0 1 4 2 0 0.162 0.533 1.000 99 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(11), RANGAP1(1) 5254489 13 10 13 2 1 5 2 5 0 0 0.224 0.536 1.000 100 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), DNMT3B(1), MARS(2), MARS2(3) 10707151 19 19 19 2 2 2 5 6 4 0 0.114 0.538 1.000 101 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(7), CR2(1), HLA-DRA(1), HLA-DRB1(12), ITGAL(4), ITGB2(1), PTPRC(6) 9271803 32 28 30 6 5 1 4 17 5 0 0.282 0.541 1.000 102 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(3), AKT3(2), GRB2(1), GSK3A(2), IL4R(2), IRS1(3), JAK1(4), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CA(12), PIK3R1(2), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), STAT6(4) 21627513 56 53 52 8 4 13 6 23 10 0 0.0252 0.552 1.000 103 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(3), HADHA(1), SDHB(1) 4874713 7 7 7 0 1 2 2 1 1 0 0.110 0.554 1.000 104 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(3), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(1), ULK3(3) 13185203 23 23 23 2 1 3 1 13 5 0 0.120 0.567 1.000 105 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), HLA-DRA(1), HLA-DRB1(12), IFNA1(2), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1) 7932143 26 23 24 5 3 5 4 12 2 0 0.176 0.575 1.000 106 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(1), GRIA2(3), PPP1R1B(1) 2194172 5 5 5 2 1 1 0 3 0 0 0.747 0.579 1.000 107 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(12), PIK3R1(2), RELA(1), SYT1(1) 10975684 31 31 28 5 1 11 3 13 3 0 0.117 0.585 1.000 108 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RB1(1), RELA(1) 12208236 36 35 29 6 5 10 2 16 3 0 0.0815 0.595 1.000 109 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), GRB2(1), HRAS(1), MAPK3(1), MEF2A(2), MEF2D(1), NTRK1(4), PIK3CA(12), PIK3R1(2), RPS6KA1(2), SHC1(2) 11780934 30 30 27 5 4 8 4 11 3 0 0.0830 0.600 1.000 110 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SEPHS1(1) 7505152 14 14 14 2 2 0 4 5 3 0 0.240 0.607 1.000 111 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ARPC1B(1), ARPC2(1), NCKAP1(1), NTRK1(4), RAC1(1), WASF2(1), WASF3(1), WASL(6) 9435096 17 17 17 2 0 3 1 12 1 0 0.229 0.612 1.000 112 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(3), POLG(2), PRPS2(2), RRM1(2) 7707287 13 13 13 2 2 3 1 5 2 0 0.215 0.614 1.000 113 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(6), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), TBXA2R(1) 6477318 17 17 17 4 1 2 4 7 3 0 0.473 0.616 1.000 114 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD2(1), GGT1(2) 3484980 5 5 5 1 0 1 2 1 1 0 0.469 0.627 1.000 115 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1) 5191321 8 7 8 0 1 1 4 2 0 0 0.0635 0.627 1.000 116 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), DNMT3B(1), MARS(2), MARS2(3), MTAP(2) 12789093 21 21 21 2 2 2 6 7 4 0 0.0802 0.630 1.000 117 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI2(4), GLI3(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SHH(1), SMO(3) 9620228 22 21 22 4 4 1 2 13 2 0 0.291 0.631 1.000 118 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(12), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2) 7709460 27 23 25 6 6 1 4 13 3 0 0.327 0.637 1.000 119 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(4), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(1) 4324396 9 9 7 3 1 0 1 1 6 0 0.933 0.637 1.000 120 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), CREM(1), FHL5(2), GNAS(4), XPO1(6) 5753041 14 14 14 3 2 1 3 7 1 0 0.521 0.638 1.000 121 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), GBA(2), GBA3(2), MPO(4), TPO(3) 5150129 12 12 12 3 1 2 4 5 0 0 0.390 0.640 1.000 122 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(2), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(1), MPST(2), SULT1B1(1), SULT4A1(1) 7728778 19 19 19 4 1 0 2 9 7 0 0.707 0.645 1.000 123 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(2) 3013227 4 4 4 0 1 0 1 0 2 0 0.467 0.645 1.000 124 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PTPRC(6) 6594819 15 13 15 3 2 2 2 8 1 0 0.356 0.646 1.000 125 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(3), GOT2(2), PAH(3), YARS(1) 5406809 10 10 10 2 0 0 3 3 4 0 0.568 0.654 1.000 126 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(1) 7829958 14 13 14 2 0 4 1 6 3 0 0.238 0.669 1.000 127 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1) 6247357 12 11 11 2 0 2 1 5 4 0 0.456 0.672 1.000 128 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI1(1), IDI2(2) 2721446 4 4 4 1 0 0 0 3 1 0 0.831 0.676 1.000 129 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1038575 1 1 1 0 0 0 0 1 0 0 0.838 0.678 1.000 130 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), NFS1(2), TPK1(1) 4001753 5 5 5 0 2 0 0 3 0 0 0.310 0.685 1.000 131 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2) 3513076 6 6 5 2 1 0 0 3 2 0 0.896 0.694 1.000 132 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEP(1), LEPR(1), PRKAG1(1), PRKAG2(4) 9049850 12 12 12 1 0 3 3 3 3 0 0.0937 0.696 1.000 133 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM7(1), GRM8(2) 11996305 25 25 25 4 4 5 1 13 2 0 0.125 0.700 1.000 134 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 953417 1 1 1 1 0 0 0 1 0 0 0.943 0.713 1.000 135 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(2), CD3G(1), HLA-A(4), ITGAL(4), ITGB2(1), PRF1(1) 5137727 15 12 15 4 1 5 2 5 2 0 0.383 0.714 1.000 136 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(1), ABCB4(1), ABCC1(2), ABCC3(7) 9082866 15 15 15 2 1 1 4 7 2 0 0.227 0.718 1.000 137 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1) 14511885 32 30 29 4 0 8 3 15 6 0 0.0483 0.722 1.000 138 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NFKB1(1), NOX1(2), RELA(1), XDH(2) 6077631 8 8 8 1 0 2 2 4 0 0 0.251 0.723 1.000 139 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), SYT1(1), TRAF3(1), TRAF5(3), TRAF6(1) 20255215 36 34 33 3 4 9 3 16 4 0 0.00313 0.727 1.000 140 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB1A(1), RAB3A(1), RAB5A(1) 2650758 3 3 3 0 1 0 1 0 1 0 0.378 0.730 1.000 141 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(2), IL3(1), KITLG(2), TGFB2(2), TGFB3(1) 5170275 9 9 9 2 0 1 1 6 1 0 0.663 0.732 1.000 142 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1) 6617914 11 11 11 2 0 3 2 3 3 0 0.443 0.735 1.000 143 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR5(3), CD28(1), CD4(2), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1) 12475000 21 19 20 2 3 2 2 13 1 0 0.0670 0.742 1.000 144 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(1), QPRT(1) 13268381 26 25 26 4 0 3 4 14 5 0 0.234 0.743 1.000 145 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(15), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), PCNA(3), RB1(1), TP53(10) 11322059 36 27 36 6 3 5 6 12 10 0 0.162 0.746 1.000 146 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B4(1), HSD3B1(1) 5022413 6 6 6 1 1 0 3 2 0 0 0.435 0.756 1.000 147 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1) 8192549 16 16 16 3 0 1 2 8 5 0 0.536 0.759 1.000 148 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(5), AOC2(3), AOC3(1), CES1(2), DDHD1(2), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 15496342 28 25 28 2 1 3 4 15 5 0 0.0494 0.761 1.000 149 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(4), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3) 5009016 14 14 12 4 0 1 2 9 2 0 0.642 0.770 1.000 150 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 10184606 15 14 15 1 1 1 3 8 2 0 0.131 0.772 1.000 151 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(4), C7(2) 7970191 12 12 12 2 1 2 1 6 2 0 0.330 0.773 1.000 152 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 3431600 11 11 11 4 0 1 3 4 3 0 0.757 0.777 1.000 153 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1), TUB(2) 4389203 6 6 6 1 0 0 0 5 1 0 0.622 0.779 1.000 154 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 2379318 2 2 2 1 0 0 1 0 1 0 0.893 0.785 1.000 155 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), PER1(4) 5237843 6 6 6 1 0 0 2 3 0 1 0.422 0.786 1.000 156 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 1401723 1 1 1 1 0 0 1 0 0 0 0.902 0.786 1.000 157 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1) 5073214 6 6 6 0 1 0 1 2 2 0 0.326 0.787 1.000 158 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(6), RPE(1), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 10943629 21 17 19 3 1 5 4 5 6 0 0.171 0.791 1.000 159 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(5), COPA(4), GBF1(6), GPLD1(1), KDELR2(2), KDELR3(2) 10108847 21 20 21 4 0 1 4 11 4 1 0.455 0.795 1.000 160 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), CHRNB1(1), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), SRC(2), TERT(4) 10201486 26 26 23 5 2 12 2 8 2 0 0.115 0.802 1.000 161 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1) 5427994 14 13 14 4 1 3 2 3 5 0 0.602 0.803 1.000 162 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), ESRRA(2), MEF2A(2), MEF2D(1), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(1) 12743303 17 17 16 1 2 1 2 7 5 0 0.133 0.808 1.000 163 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1) 4223555 5 5 5 0 0 0 1 4 0 0 0.364 0.811 1.000 164 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(1), AKR1B10(2), ALAS1(4), ALAS2(3), AOC2(3), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), GNMT(2), MAOA(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2), TARS2(3) 26493557 61 57 60 8 5 10 13 27 6 0 0.00495 0.817 1.000 165 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), HSPB2(1), MAP2K6(1), MAP3K1(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK14(1), MAPKAPK2(2), MAPKAPK5(1), MAX(3), MEF2A(2), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1) 22702665 48 46 47 6 4 3 3 28 10 0 0.0778 0.820 1.000 166 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDKN1A(1), NEK1(2), WEE1(1) 4601050 5 5 5 1 0 1 0 3 1 0 0.707 0.827 1.000 167 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(1), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5), SYT1(1) 13786023 25 25 23 4 1 5 1 15 3 0 0.223 0.834 1.000 168 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(2), HSD3B1(1) 5740192 7 7 7 0 0 0 1 5 1 0 0.303 0.844 1.000 169 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(2), HSD3B1(1) 5740192 7 7 7 0 0 0 1 5 1 0 0.303 0.844 1.000 170 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(2), MAPK14(1), THBS1(6) 4457452 10 10 10 3 0 0 2 7 1 0 0.790 0.850 1.000 171 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1) 2048015 2 2 2 1 0 0 0 1 1 0 0.951 0.850 1.000 172 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(1), PON3(2), RDH11(3) 5499382 8 8 8 2 1 0 3 4 0 0 0.550 0.853 1.000 173 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(2), HK1(4), PFKL(1), PGAM1(1), PGK1(2), TPI1(1) 5618781 14 12 14 4 2 2 2 4 4 0 0.551 0.853 1.000 174 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(1) 8764661 12 11 12 2 3 1 3 5 0 0 0.205 0.854 1.000 175 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CHIT1(6), CTBS(1), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(1), RENBP(2) 17800239 33 31 32 4 5 3 5 13 7 0 0.0622 0.854 1.000 176 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST5(1), NDST1(2), NDST2(2), NDST4(3) 12515265 16 16 16 1 2 3 5 6 0 0 0.0312 0.861 1.000 177 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), IDH1(2), MDH1(1), SDHB(1) 5550156 8 8 8 2 1 0 1 5 1 0 0.570 0.862 1.000 178 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SLC2A4(1), SOS1(6), SRF(1) 15351307 40 38 37 8 3 14 5 16 2 0 0.0831 0.864 1.000 179 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(1), CDC42(1), CFL1(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(3), PTEN(20), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(2), WASL(6) 43511786 102 85 99 11 4 24 10 37 26 1 0.000101 0.868 1.000 180 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 1256994 1 1 1 1 0 0 0 1 0 0 0.940 0.874 1.000 181 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(6), CDH1(2), CREBBP(4), EP300(6), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1) 15938463 25 25 25 3 1 3 7 13 1 0 0.0575 0.875 1.000 182 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 DHRS2(1), ECHS1(2), EHHADH(3), ESCO1(2), ESCO2(1), FN3K(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1) 15997725 23 22 23 2 2 3 4 9 5 0 0.0835 0.877 1.000 183 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNE1(2), CDK2(2), CDK4(1), CDKN2A(5), E2F1(1), PRB1(7) 5508148 22 21 21 9 2 3 3 8 6 0 0.796 0.877 1.000 184 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2C1(5), NEU1(1) 9707266 17 16 17 3 2 2 2 10 1 0 0.305 0.878 1.000 185 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F5(4), F7(1), FGA(1), FGG(1), PROC(4), PROS1(4), TFPI(1) 10095035 19 19 19 4 0 2 1 11 5 0 0.573 0.887 1.000 186 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(2) 15122744 26 25 26 3 3 2 7 10 4 0 0.0713 0.893 1.000 187 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(4), EGFR(7), GRB2(1), HRAS(1), MAPK3(1), PTPRB(3), RASA1(3), SHC1(2), SOS1(6), SPRY2(2), SPRY4(2), SRC(2) 15443263 35 32 34 6 4 11 5 10 5 0 0.0905 0.893 1.000 188 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), GREB1(10), HSPB2(1), MTA1(1), MTA3(1) 6525181 15 14 14 4 0 1 2 11 1 0 0.654 0.894 1.000 189 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1) 6086980 8 8 8 2 1 1 0 4 2 0 0.304 0.894 1.000 190 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1) 5188358 10 10 10 3 0 1 1 5 3 0 0.807 0.894 1.000 191 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(2), CSF2RB(1), IL3(1), KIT(3), KITLG(2), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 13399418 33 33 30 7 3 7 3 18 2 0 0.177 0.895 1.000 192 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6518339 9 9 9 2 2 1 1 5 0 0 0.414 0.897 1.000 193 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(1), IDI1(1), LSS(2), PMVK(1), SC5DL(1) 6858053 8 8 8 1 0 0 1 6 1 0 0.517 0.898 1.000 194 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1) 8092237 15 14 15 3 0 4 3 4 4 0 0.252 0.898 1.000 195 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3) 6430629 15 15 15 4 1 0 2 7 5 0 0.754 0.898 1.000 196 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3) 6430629 15 15 15 4 1 0 2 7 5 0 0.754 0.898 1.000 197 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(3), TRAF6(1) 9068511 12 12 12 2 0 3 0 6 3 0 0.500 0.899 1.000 198 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1) 8180078 10 10 10 1 0 0 1 7 2 0 0.447 0.899 1.000 199 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(2) 2390471 4 4 4 2 0 0 2 1 1 0 0.861 0.902 1.000 200 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(2), NAT1(1), NAT2(2), XDH(2) 4930345 10 10 10 3 1 1 2 5 1 0 0.592 0.902 1.000 201 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 DAXX(4), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(2) 6815254 9 9 8 2 1 1 1 4 2 0 0.625 0.903 1.000 202 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 2114168 1 1 1 1 0 0 0 0 1 0 0.967 0.905 1.000 203 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(3), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF5(2) 7115245 10 10 10 2 1 1 2 3 3 0 0.563 0.919 1.000 204 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RB1(1), RELA(1) 12535134 30 29 27 6 2 10 3 11 4 0 0.165 0.920 1.000 205 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5) 10216827 17 17 17 3 2 0 0 11 4 0 0.428 0.923 1.000 206 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), PDHA1(1), PDHA2(1), SLC18A3(1) 4103632 4 4 4 1 0 0 0 2 2 0 0.868 0.926 1.000 207 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK4(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(3), FGF2(1), GATA4(1), HRAS(1), MAPK14(1), MAPK3(1), MYH2(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NPPA(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KB1(1), SYT1(1) 30760856 65 60 62 9 6 11 7 29 12 0 0.0138 0.926 1.000 208 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1) 9112464 11 10 11 1 1 2 2 5 1 0 0.212 0.927 1.000 209 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 1903259 1 1 1 0 0 0 0 1 0 0 0.855 0.929 1.000 210 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 11480316 31 30 28 7 2 10 3 15 1 0 0.259 0.932 1.000 211 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1) 5409612 10 9 10 3 1 2 1 2 4 0 0.675 0.933 1.000 212 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CFL1(1), CHN1(2), MAP3K1(5), MYL2(1), MYLK(4), NCF2(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(2) 21681433 46 41 43 6 1 7 4 23 11 0 0.0614 0.935 1.000 213 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ITGAL(4), ITGAM(3), ITGB2(1), SELE(4) 6658595 13 13 13 4 1 4 3 3 2 0 0.583 0.940 1.000 214 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(1), IFNB1(2), JAK1(4), STAT1(4), STAT2(3), TYK2(3) 6655388 19 19 19 5 1 4 2 7 5 0 0.427 0.941 1.000 215 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(2), JAK1(4), STAT1(4), STAT3(1) 7417728 12 12 12 3 1 0 0 7 4 0 0.769 0.942 1.000 216 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(3), AKT3(2), BRAF(1), FIGF(3), HIF1A(3), MAPK3(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RHEB(4), RICTOR(3), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(2), TSC2(5), ULK1(1), ULK2(1), ULK3(3) 32763066 64 61 58 8 5 13 8 28 10 0 0.00489 0.945 1.000 217 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), PRKCE(4) 4893734 10 10 9 4 0 0 1 5 4 0 0.939 0.945 1.000 218 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), TOP2A(3), TOP2B(1) 6310068 5 5 5 0 2 1 0 2 0 0 0.278 0.948 1.000 219 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(1) 1919062 1 1 1 1 0 0 0 1 0 0 0.937 0.950 1.000 220 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(2), CSNK1A1(1), MAPT(1), PPP2CA(1) 5781880 5 5 5 0 0 0 1 1 3 0 0.368 0.951 1.000 221 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(5), ACADM(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2) 16448248 35 33 35 7 3 5 11 10 6 0 0.163 0.956 1.000 222 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), DPM2(1), GRB2(1), HRAS(1), KLK2(1), NTRK1(4), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 9495902 32 30 29 8 1 10 4 15 2 0 0.336 0.957 1.000 223 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT1(1), LCMT2(3), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1) 8602143 12 11 12 2 1 2 1 7 1 0 0.436 0.960 1.000 224 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(3) 6009360 10 10 10 3 0 3 0 4 3 0 0.725 0.960 1.000 225 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(5), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), SYT1(1) 16701000 26 26 26 4 4 4 0 14 4 0 0.165 0.961 1.000 226 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1) 5980500 12 12 12 4 0 5 1 6 0 0 0.533 0.963 1.000 227 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2) 10747686 18 18 18 4 2 5 1 8 2 0 0.345 0.964 1.000 228 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(6), AXIN1(2), BTRC(2), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(1) 18016701 28 27 27 4 2 3 5 16 2 0 0.0782 0.966 1.000 229 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1) 12025433 19 17 19 3 2 2 3 11 1 0 0.223 0.967 1.000 230 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), ATIC(1), GART(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3) 11147479 16 16 16 3 3 2 0 7 4 0 0.392 0.967 1.000 231 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), MAP3K1(5), MAP3K14(1), NFKB1(1), RELA(1), TRAF3(1), TRAF6(1) 11335637 13 12 13 2 0 3 0 4 6 0 0.405 0.967 1.000 232 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(1), RB1(1) 5264017 10 9 10 4 1 2 1 2 4 0 0.852 0.968 1.000 233 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(3), AKT3(2), GRB2(1), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(4), PIK3CA(12), PPP1R13B(3), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT6(4), TYK2(3) 22603626 64 58 60 11 2 14 9 26 13 0 0.0744 0.969 1.000 234 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), IL3(1), IL4(1) 3759317 4 4 4 2 0 1 1 2 0 0 0.848 0.969 1.000 235 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), ITPKA(1), ITPKB(2) 3566789 4 4 4 2 1 0 0 1 2 0 0.926 0.969 1.000 236 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), ATIC(1), FTCD(1), GART(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3) 11799824 17 17 17 3 3 2 0 8 4 0 0.358 0.969 1.000 237 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), EIF4E(1), FBL(1), GPT(1), LDHB(1), LDHC(1), MAPK14(1), NCL(3) 5538188 15 15 15 6 0 0 4 7 4 0 0.938 0.970 1.000 238 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TPO(3) 13461982 30 26 30 6 2 4 9 11 4 0 0.207 0.971 1.000 239 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), PRF1(1) 6511345 5 5 5 0 0 2 1 2 0 0 0.193 0.973 1.000 240 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 CHST11(1), CHST12(1), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(2) 5320563 11 11 11 4 2 0 4 1 4 0 0.827 0.974 1.000 241 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(15), ATR(5), BRCA1(6), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK2(3), EP300(6), MYT1(2), PRKDC(7), RPS6KA1(2), TP53(10), WEE1(1) 26752095 61 53 59 9 3 6 11 29 12 0 0.0555 0.975 1.000 242 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1) 11432703 16 16 16 3 2 2 4 7 1 0 0.261 0.975 1.000 243 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(2), PKM2(1), RPE(1), TPI1(1) 10998103 24 23 24 6 0 3 4 6 11 0 0.608 0.975 1.000 244 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(2), IFNB1(2), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(2), JUN(2), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1), TRAF6(1) 18348027 41 38 36 7 7 8 0 19 7 0 0.128 0.976 1.000 245 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(2) 3640818 4 4 4 2 1 2 0 1 0 0 0.656 0.976 1.000 246 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(2) 3640818 4 4 4 2 1 2 0 1 0 0 0.656 0.976 1.000 247 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2) 5230020 8 8 8 3 0 2 0 3 3 0 0.822 0.976 1.000 248 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), JUNB(2), MAF(1), MAP2K3(9), MAPK14(1), NFATC1(1), NFATC2(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 6884313 25 22 21 8 7 0 1 16 1 0 0.537 0.977 1.000 249 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2) 3382326 7 7 7 3 0 2 1 4 0 0 0.684 0.978 1.000 250 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(2) 3799740 8 8 8 3 1 0 4 1 2 0 0.701 0.978 1.000 251 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 15436406 23 22 22 4 2 2 3 12 4 0 0.369 0.980 1.000 252 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(2), GHR(1), HRAS(1), PIK3CA(12), PIK3R1(2), SHC1(2) 8024432 22 22 19 6 1 7 3 9 2 0 0.407 0.981 1.000 253 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1), SPAM1(4) 20800172 46 37 44 8 7 6 7 22 4 0 0.0524 0.981 1.000 254 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(6), AR(1), ASAH1(1), BRAF(1), EGFR(7), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(12), PIK3R1(2), PITX2(1), SRC(2) 33003649 61 51 57 7 5 15 10 25 6 0 0.00118 0.982 1.000 255 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(2), HRAS(1), KLK2(1), MAPK3(1), NGFR(1) 4965774 7 7 7 3 2 1 0 4 0 0 0.757 0.982 1.000 256 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(5), GAB1(1), ITPR1(2), ITPR2(8), ITPR3(3), PDK1(1), PHF11(1), PIK3CA(12), PITX2(1), PLCG2(1), PPP1R13B(3), PREX1(6), PTEN(20), PTPRC(6), RPS6KA1(2), RPS6KB1(1), SAG(2), SYK(1), TEC(5), VAV1(2) 34254072 93 83 90 15 7 18 9 33 25 1 0.00664 0.982 1.000 257 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), PER1(4), PER2(3), PER3(2) 10468412 11 11 11 2 1 0 4 4 1 1 0.324 0.982 1.000 258 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(2), CFTR(4), GNAS(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 7871603 20 20 20 5 2 2 0 13 3 0 0.758 0.983 1.000 259 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(1), TPH1(1) 3613727 4 4 4 2 0 1 1 1 1 0 0.864 0.983 1.000 260 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), LDLR(1), LPL(1) 3253171 3 3 3 2 0 2 0 1 0 0 0.850 0.984 1.000 261 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(5), JAK3(4), MAPK3(1), STAT3(1), TYK2(3) 7221566 18 18 18 8 1 0 3 9 5 0 0.939 0.985 1.000 262 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME3(2), PGK1(2), PKM2(1), RPE(1), TKTL1(1), TKTL2(3), TPI1(1) 12309174 26 26 26 6 0 2 4 8 12 0 0.612 0.985 1.000 263 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), EGF(4), EGFR(7), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTK2(1), TLN1(4) 20377128 40 39 39 7 6 4 4 18 8 0 0.200 0.985 1.000 264 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(1), CHST7(1), CHSY1(3), DSE(1), XYLT1(1), XYLT2(2) 7571863 14 14 14 4 2 4 0 5 3 0 0.433 0.986 1.000 265 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6143964 9 9 9 3 2 1 1 5 0 0 0.600 0.986 1.000 266 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), IFNB1(2), NFKB1(1), RELA(1), TRAF6(1) 6682612 6 6 6 2 0 4 0 1 1 0 0.664 0.988 1.000 267 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(1), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), TPO(3) 20920218 42 37 42 7 3 5 10 18 6 0 0.0994 0.989 1.000 268 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(15), CDC25A(1), CDC25C(2), CDK2(2), CDK4(1), MYT1(2), RB1(1), TP53(10), WEE1(1) 11054004 35 29 35 9 2 4 6 14 9 0 0.502 0.990 1.000 269 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(2), RIPK1(1), TNFRSF1A(1), TRADD(1) 4852865 6 6 6 3 0 3 1 1 1 0 0.770 0.990 1.000 270 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT3(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1) 4775395 4 4 4 4 0 0 1 1 2 0 0.986 0.991 1.000 271 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(3), CD3E(2), CD3G(1), CD4(2), IL12RB1(1), IL12RB2(2), JAK2(5), STAT4(1), TYK2(3) 9171081 20 18 19 5 1 2 3 12 2 0 0.499 0.991 1.000 272 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(2), JAK1(4), PTPRU(4), STAT1(4), STAT2(3), TYK2(3) 7631359 21 21 21 6 1 2 2 11 5 0 0.560 0.992 1.000 273 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA2B(1), P2RY2(1), P2RY6(1) 3391119 4 4 4 5 0 0 0 3 1 0 0.986 0.992 1.000 274 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(2), ALOX5(2), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1) 9356670 20 19 19 5 1 3 6 6 4 0 0.386 0.993 1.000 275 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(1), CDC25C(2), MYT1(2), WEE1(1) 8602771 21 18 21 5 0 2 3 10 6 0 0.561 0.993 1.000 276 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1) 23032826 57 55 53 10 4 12 6 25 10 0 0.0859 0.994 1.000 277 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD33(1), CD7(3), IFNA1(2), IFNB1(2), IL3(1), IL4(1), ITGAX(2), TLR2(2), TLR4(2), TLR7(2), TLR9(1) 11312503 25 25 25 7 2 5 5 9 3 1 0.568 0.994 1.000 278 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), B3GNT7(1), B4GALT3(1), B4GALT4(2), CHST1(1), CHST4(1), ST3GAL1(1), ST3GAL3(1) 7106875 10 10 10 4 0 3 2 1 4 0 0.798 0.995 1.000 279 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CAP1(1), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KA1(2), SRC(2) 12410831 28 27 28 7 4 3 0 18 3 0 0.519 0.995 1.000 280 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(3) 10984503 16 16 16 4 1 5 1 6 3 0 0.495 0.996 1.000 281 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), GRB2(1), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1) 10810069 22 21 22 5 3 3 3 11 2 0 0.377 0.996 1.000 282 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(15), ATR(5), CCNA1(4), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), E2F1(1), HDAC1(2), RB1(1), SKP2(1), TGFB2(2), TGFB3(1), TP53(10) 18505183 58 47 58 11 5 9 7 22 15 0 0.160 0.996 1.000 283 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(4), JAK2(5), JAK3(4), PIAS1(2), PTPRU(4) 8521358 19 16 19 5 0 1 3 10 5 0 0.656 0.996 1.000 284 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), GRB2(1), HRAS(1), IRS1(3), MAPK3(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 11398430 30 29 27 8 3 10 3 13 1 0 0.273 0.997 1.000 285 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(5) 5132206 6 6 6 3 2 1 0 3 0 0 0.799 0.997 1.000 286 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1) 4476618 5 5 5 3 0 1 0 3 1 0 0.949 0.997 1.000 287 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(2), IFNGR2(1), JAK2(5), NFKB1(1), RB1(1), RELA(1), TNFRSF1A(1), TP53(10), USH1C(3), WT1(3) 11014022 29 27 29 9 2 5 4 11 7 0 0.654 0.997 1.000 288 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1) 4381376 9 9 9 4 0 0 1 7 1 0 0.921 0.997 1.000 289 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKG1(2), PRKG2(2) 19142752 33 31 33 6 4 5 3 18 3 0 0.202 0.997 1.000 290 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2I(3), GTF2IRD1(1), STON1(1), TAF1(5), TAF13(1), TAF1L(4), TAF2(2), TAF4(2), TAF4B(2), TAF5(2), TAF5L(2), TAF6(1), TAF7L(4) 22125447 37 36 37 6 2 4 4 22 5 0 0.160 0.998 1.000 291 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(2), FDPS(1), IDI1(1), IDI2(2), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1) 11924405 12 12 12 2 0 0 1 8 3 0 0.591 0.998 1.000 292 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(1), AGTR1(1), BDKRB2(1), KNG1(2), NOS3(2), REN(1) 5996482 10 9 10 4 1 2 2 4 1 0 0.701 0.998 1.000 293 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL10(1), BID(1), CASP8AP2(4), CES1(2) 7145394 8 8 8 3 0 1 0 4 3 0 0.874 0.998 1.000 294 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(4), ALAS2(3), CPOX(1), FECH(2) 4773876 10 10 9 4 0 0 2 7 1 0 0.833 0.998 1.000 295 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GFPT1(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2) 10526097 13 12 13 3 3 0 2 6 2 0 0.488 0.998 1.000 296 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1) 21462996 53 51 50 10 3 11 4 26 9 0 0.122 0.998 1.000 297 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), PON3(2) 10895365 19 18 19 5 1 5 2 9 2 0 0.407 0.998 1.000 298 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(1), RELN(3), VLDLR(2) 8652493 10 10 10 3 0 3 0 5 2 0 0.822 0.998 1.000 299 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HARS(1), MAOA(1), PRPS1(1), PRPS2(2) 15001144 30 28 30 7 2 6 7 12 3 0 0.269 0.998 1.000 300 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP19(1), SRP68(2), SRP72(2), SRP9(1) 4691704 7 7 7 3 0 2 1 4 0 0 0.825 0.998 1.000 301 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(4), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), E2F1(1), RB1(1) 9811377 21 20 21 7 2 3 2 8 6 0 0.744 0.998 1.000 302 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(3), AKT1(2), AKT2(3), AKT3(2), ATM(15), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(2), IRAK4(1), MAP3K14(1), NFKB1(1), NTRK1(4), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1) 51677192 111 99 106 16 8 21 15 49 18 0 0.00245 0.998 1.000 303 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1) 8252375 13 13 12 5 1 1 0 7 4 0 0.910 0.998 1.000 304 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F2(3), FGA(1), FGG(1), PLAT(2), PLAU(4), PLG(5) 8404887 16 16 16 5 0 1 3 8 4 0 0.737 0.998 1.000 305 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), LTA(1), MAP3K1(5), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1) 13819333 15 14 15 3 1 3 0 5 6 0 0.418 0.999 1.000 306 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 4892942 7 7 7 5 0 1 1 4 1 0 0.971 0.999 1.000 307 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 4892942 7 7 7 5 0 1 1 4 1 0 0.971 0.999 1.000 308 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2) 17731273 36 34 36 9 3 5 12 11 5 0 0.307 0.999 1.000 309 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(15), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNG2(1), CD82(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CHEK2(3), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), PTEN(20), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(6), TP53(10), TP53I3(4), TP73(3), TSC2(5) 39981246 112 90 111 18 10 13 16 35 37 1 0.0147 0.999 1.000 310 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CD97(3), CRHR2(1), ELTD1(2), EMR1(1), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(2), LPHN3(7), SCTR(1), VIPR1(1) 17047766 30 28 30 6 3 4 3 16 4 0 0.186 0.999 1.000 311 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), ATM(15), BID(1), CASP7(1), PTK2(1), STAT1(4), TLN1(4), TP53(10) 17122645 38 33 38 8 4 5 5 16 8 0 0.271 0.999 1.000 312 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(1), RELA(1) 5102963 3 3 3 3 0 2 0 0 1 0 0.921 0.999 1.000 313 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(4), JAK2(5), JAK3(4), PTPRU(4), SRC(2), STAT3(1) 9373255 20 18 20 8 0 2 2 11 5 0 0.917 0.999 1.000 314 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(1) 4578285 7 6 7 5 1 0 2 3 1 0 0.951 0.999 1.000 315 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(6), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1) 13582745 17 17 17 4 0 4 5 5 3 0 0.397 0.999 1.000 316 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), ECHS1(2), EHHADH(3), HADHA(1), HADHB(2), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 22330728 41 41 40 9 3 7 8 17 6 0 0.270 0.999 1.000 317 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(4), LCT(2), MPI(1), PYGL(1), PYGM(2), TPI1(1), TREH(2) 8385889 17 16 16 5 3 0 4 6 4 0 0.611 0.999 1.000 318 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(3) 9325297 13 13 13 4 0 3 0 7 3 0 0.754 0.999 1.000 319 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), NFAT5(7), PDE6A(1), PDE6B(2), PDE6C(2), SLC6A13(2) 22326766 35 31 34 6 4 3 6 17 5 0 0.121 0.999 1.000 320 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 JUN(2), KEAP1(2), MAPK14(1), NFE2L2(6) 5381736 11 11 11 5 0 1 2 7 1 0 0.864 0.999 1.000 321 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(1), HARS(1), HARS2(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1) 24273581 43 37 43 7 3 10 8 17 5 0 0.0534 0.999 1.000 322 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(2), MDH1(1), ME1(1), PC(1), PDHA1(1) 5716800 9 9 9 4 0 3 1 4 1 0 0.700 0.999 1.000 323 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(15), BMPR1B(1), CCND2(1), CDK4(1), EGR1(2), ESR2(1), GJA4(1), MLH1(1), NCOR1(5), NRIP1(6), PGR(1), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1) 21016551 41 36 41 7 2 7 6 17 9 0 0.0872 0.999 1.000 324 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), DLD(2), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HADHB(2), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 26726464 47 47 46 9 4 7 10 19 7 0 0.140 0.999 1.000 325 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(6), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), NOTCH1(5) 12458770 20 20 19 5 3 3 3 11 0 0 0.350 0.999 1.000 326 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(4), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC5(2), ST8SIA1(2), ST8SIA5(1) 9926916 21 20 21 6 2 4 2 10 3 0 0.425 0.999 1.000 327 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), HLA-A(4), ITGB1(3), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(1), PIK3CA(12), PIK3R1(2), PTK2B(2), PTPN6(3), RAC1(1), SYK(1), VAV1(2) 11559475 40 36 36 10 2 12 5 12 9 0 0.338 0.999 1.000 328 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(6), RPE(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), XYLB(1) 16942394 33 29 31 8 2 5 6 13 7 0 0.404 0.999 1.000 329 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(3), CD3E(2), CD3G(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(3) 11604034 23 21 22 6 1 1 3 16 2 0 0.619 0.999 1.000 330 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PDE1A(1), PDE1B(2), PLCB1(1), PLCB2(2) 6781922 8 8 8 5 1 1 0 4 2 0 0.932 0.999 1.000 331 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), C8B(2), MASP1(1) 12799458 21 21 21 5 4 5 1 9 2 0 0.321 0.999 1.000 332 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), ECHS1(2), EHHADH(3), ESCO1(2), ESCO2(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1) 19051907 29 27 29 5 2 4 4 13 6 0 0.245 0.999 1.000 333 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(3) 7158734 10 10 10 4 1 3 1 2 3 0 0.785 0.999 1.000 334 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TLR10(1), TLR2(2), TLR4(2), TLR6(1), TLR7(2), TLR9(1), TRAF6(1) 22241562 38 34 34 7 5 6 1 18 8 0 0.201 0.999 1.000 335 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(9), ARHGEF1(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), ROCK1(4) 12616665 26 24 24 7 0 3 2 14 6 1 0.567 1.000 1.000 336 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(3), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2B(2), ROCK1(4) 15834125 34 33 31 8 0 8 3 16 7 0 0.311 1.000 1.000 337 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2) 7967216 15 15 15 5 3 1 2 8 1 0 0.605 1.000 1.000 338 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(4), GRIN2B(5), NOS1(8), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1) 15677959 33 32 33 9 6 7 1 19 0 0 0.362 1.000 1.000 339 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), MASP1(1), MASP2(1), MBL2(1) 13155421 21 21 21 5 3 6 1 9 2 0 0.307 1.000 1.000 340 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2) 8506571 15 14 15 5 1 3 4 5 2 0 0.587 1.000 1.000 341 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(4), ACSS1(3), ACSS2(3), IDH1(2), MDH1(1) 8259902 16 15 16 7 1 3 2 7 3 0 0.849 1.000 1.000 342 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 1.000 1.000 343 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 1.000 1.000 344 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 1.000 1.000 345 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25C(2), CSK(2), GRB2(1), PTPRA(1), SRC(2) 5682399 9 9 9 4 0 4 0 5 0 0 0.731 1.000 1.000 346 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(2), MDH1(1), OGDH(3), SDHA(1) 5886443 7 7 7 6 1 1 1 3 1 0 0.985 1.000 1.000 347 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2) 8361460 15 15 15 5 3 1 2 8 1 0 0.604 1.000 1.000 348 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(1) 7410165 13 13 13 5 0 4 3 4 2 0 0.751 1.000 1.000 349 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(4) 6297228 4 3 4 3 2 0 0 1 1 0 0.925 1.000 1.000 350 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), HADHA(1) 7514224 13 13 13 5 1 3 2 5 2 0 0.764 1.000 1.000 351 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1) 14030803 32 31 32 7 2 3 6 17 4 0 0.290 1.000 1.000 352 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(2), ILVBL(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1), VARS(2), VARS2(1) 10458655 18 16 17 7 0 4 1 8 5 0 0.836 1.000 1.000 353 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(6), FYN(1), JAK1(4), JAK3(4), PIK3CA(12), PIK3R1(2), PTK2B(2), STAT5B(1) 17367079 36 34 33 9 0 9 7 15 5 0 0.381 1.000 1.000 354 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), IDH1(2), MGST3(2), OPLAH(4), TXNDC12(1) 13487704 30 28 28 9 2 0 7 12 9 0 0.838 1.000 1.000 355 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELE(4) 7632567 14 14 14 5 1 4 4 3 2 0 0.647 1.000 1.000 356 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9951143 13 13 13 6 0 1 3 5 4 0 0.924 1.000 1.000 357 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(1), TPH1(1) 8603208 13 12 13 6 0 2 4 4 3 0 0.881 1.000 1.000 358 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(12), PIK3R1(2), PLCB1(1), VAV1(2) 7995805 19 19 16 8 1 7 3 6 2 0 0.685 1.000 1.000 359 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(2), CPS1(6), CTH(1), GLS(4), GLS2(2) 11750482 21 21 21 6 1 3 3 14 0 0 0.542 1.000 1.000 360 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IL1R1(1), IRAK1(3), MAP3K1(5), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(1), TRAF6(1) 14751144 20 18 20 6 1 5 1 5 8 0 0.621 1.000 1.000 361 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2) 12255271 17 17 17 9 0 3 2 6 6 0 0.954 1.000 1.000 362 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(6), ATF2(1), AXIN1(2), BMP2(1), BMP5(1), BMP7(2), BMPR2(4), CHRD(2), CTNNB1(1), DVL1(1), FZD1(2), GATA4(1), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1) 22030650 37 35 37 7 2 6 3 23 3 0 0.168 1.000 1.000 363 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PITX2(1), PLD1(2), PLD2(2), PLD3(3) 27547566 40 33 40 6 3 8 6 16 7 0 0.0323 1.000 1.000 364 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), CS(2), DLD(2), DLST(1), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(1), PCK1(4), SDHA(1), SDHB(1), SUCLG1(5), SUCLG2(1) 12807968 27 26 27 9 3 1 4 13 6 0 0.767 1.000 1.000 365 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(4), IMPA2(2) 7125667 6 5 6 4 3 0 0 2 1 0 0.924 1.000 1.000 366 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY6(1), ADCY8(6), CACNA1A(5), CACNA1B(4), GNAS(4), GNB1(2), GNG3(1), GRM4(3), ITPR3(3), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(4), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R1(1), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(1) 35196925 70 62 69 12 13 4 7 29 16 1 0.0977 1.000 1.000 367 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(6), AXIN1(2), CREBBP(4), CTNNB1(1), DVL1(1), EP300(6), FZD1(2), HDAC1(2), LDB1(1), LEF1(1), PITX2(1), TRRAP(3) 20298608 30 29 30 6 1 3 7 18 1 0 0.209 1.000 1.000 368 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(1), SNX13(2), SRC(2) 7140864 7 7 7 5 0 3 0 3 1 0 0.948 1.000 1.000 369 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(2), CBR1(2), CYP4F2(1), EPX(1), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(1), PTGS2(4), TBXAS1(1), TPO(3) 17084735 31 31 30 8 4 5 8 10 4 0 0.280 1.000 1.000 370 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(6), CALM2(1), CAMK1(1), INSR(3), MAP2K6(1), MAPK14(1), MEF2A(2), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1) 21068820 37 37 34 9 3 10 5 14 5 0 0.233 1.000 1.000 371 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), SELE(4), SELP(1) 10101136 18 18 18 7 1 5 5 4 3 0 0.750 1.000 1.000 372 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), PSMD11(1), PSMD2(2), PSMD6(1) 9978802 14 14 14 6 1 2 1 7 3 0 0.913 1.000 1.000 373 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), PC(1) 16111652 23 22 23 7 1 2 7 4 9 0 0.613 1.000 1.000 374 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(7), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 16843009 25 22 23 9 2 2 3 9 9 0 0.831 1.000 1.000 375 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(1), CHUK(1), JUN(2), LTA(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1) 14782944 31 28 27 9 5 3 1 16 6 0 0.669 1.000 1.000 376 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(4), C7(2), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELP(1), SELPLG(1), VCAM1(1) 15393560 24 24 24 7 2 4 4 10 4 0 0.507 1.000 1.000 377 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(2), CPS1(6), CTH(1), GLS(4), GLS2(2) 13113172 21 21 21 6 1 3 3 14 0 0 0.539 1.000 1.000 378 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(2), SHC1(2), SOS1(6), SYK(1), VAV1(2), VAV2(4) 19485389 33 30 33 8 4 5 3 18 3 0 0.312 1.000 1.000 379 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP3K1(5), MAPK3(1), NFKB1(1), NSMAF(3), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1) 12585853 15 15 15 5 1 4 1 4 5 0 0.564 1.000 1.000 380 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(15), BRCA1(6), CDKN1A(1), CHEK2(3), JUN(2), NFKB1(1), RAD50(4), RAD51(2), RELA(1), TP53(10), TP73(3) 18215089 52 46 51 11 4 8 9 21 10 0 0.216 1.000 1.000 381 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKL(1), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2), TKTL1(1), TKTL2(3) 14777530 22 22 22 9 0 4 2 9 7 0 0.880 1.000 1.000 382 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), ILVBL(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2), VNN1(1) 10603495 17 16 17 7 1 3 4 6 3 0 0.801 1.000 1.000 383 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(1), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1) 8078902 8 8 8 5 2 3 0 2 1 0 0.875 1.000 1.000 384 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(1), FYN(1), ITGA1(3), ITGB1(3), L1CAM(4), SELP(1) 9750850 13 13 13 8 2 2 1 6 2 0 0.963 1.000 1.000 385 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), GOT1(3), GOT2(2), HGD(1), MAOA(1), TH(1), TPO(3), TYR(3) 19435512 47 41 46 12 3 5 8 20 11 0 0.533 1.000 1.000 386 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT3(1), B4GALT5(1), DPAGT1(2), DPM1(1), MAN1A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), RPN1(2), RPN2(1) 11842267 17 17 17 9 0 4 0 9 4 0 0.951 1.000 1.000 387 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(1), ADRB2(2), CHRM2(2), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1) 15295241 26 25 26 8 4 3 2 13 4 0 0.559 1.000 1.000 388 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(4), FLT4(6), KDR(5), NOS3(2), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKG1(2), PRKG2(2), RYR2(10), SLC7A1(1), SYT1(1), TNNI1(1) 25547675 56 52 56 12 11 8 6 25 6 0 0.117 1.000 1.000 389 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(5), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), MET(3), MYC(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARD3(2), PARD6A(2), PDK1(1), PIK3CA(12), PPP1R13B(3), PREX1(6), PTEN(20), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(6), SOS2(1), TSC1(2), TSC2(5), YWHAE(1) 46422402 113 98 109 21 8 18 9 48 29 1 0.0646 1.000 1.000 390 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACADS(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(3), HADHA(1), PECR(1), SCP2(2) 10425285 13 13 12 5 2 4 2 3 2 0 0.624 1.000 1.000 391 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(1), ALAS1(4), ALAS2(3), AOC2(3), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), MAOA(1), PISD(1), PLCB2(2), PLCG2(1), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2) 26059364 50 47 49 10 3 7 12 22 6 0 0.123 1.000 1.000 392 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(6), MAP2K3(9), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR2(1), TLR2(2) 18349352 29 28 25 7 4 3 4 14 4 0 0.468 1.000 1.000 393 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(2), ABCC2(1), BCHE(2), CES1(2), CES2(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2) 14211148 17 15 17 5 1 3 3 5 5 0 0.688 1.000 1.000 394 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(4), JUN(2), MAPK3(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1) 14274671 27 26 27 9 3 4 2 13 5 0 0.743 1.000 1.000 395 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(5), DDX20(4), E2F1(1), HRAS(1), JUN(2), NCOR2(4), RBL2(2), SIN3A(2), SIN3B(1) 16312283 22 22 22 6 0 3 3 12 4 0 0.492 1.000 1.000 396 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(2), NFATC3(3), NR2C2(1), PAPPA(1), SHC1(2), TP53(10), TRAF6(1), ZAK(1) 30785255 65 59 64 12 6 5 11 31 12 0 0.115 1.000 1.000 397 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ASL(1), CPS1(6), GATM(2), ODC1(1), OTC(1), PYCR1(1), SMS(2) 10815043 16 16 16 7 0 1 3 10 2 0 0.917 1.000 1.000 398 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), RELA(1) 9302000 10 10 10 5 3 2 0 4 1 0 0.787 1.000 1.000 399 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(15), ATR(5), BRCA1(6), BRCA2(8), CHEK2(3), FANCA(4), FANCD2(2), FANCE(2), FANCF(2), FANCG(3), HUS1(2), RAD17(1), RAD50(4), RAD51(2), TP53(10), TREX1(1) 27398816 70 58 68 13 4 11 11 31 13 0 0.135 1.000 1.000 400 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(6), MAPK3(1), PELP1(1), SRC(2) 9176202 14 14 14 5 1 3 4 5 1 0 0.666 1.000 1.000 401 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(2), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(3), FLNC(4), FSCN1(3), MYH2(7), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6) 28974920 52 46 52 10 3 12 3 22 12 0 0.136 1.000 1.000 402 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(1), CFLAR(1), DAXX(4), JUN(2), LMNB1(1), MAP3K1(5), MAP3K7(1), PAK1(1), PRKDC(7), PTPN13(7), RB1(1), RIPK2(1), SPTAN1(5) 26303460 41 36 40 8 2 4 4 21 10 0 0.323 1.000 1.000 403 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), HADHB(2), SOAT2(3) 14365999 19 18 18 8 1 2 2 10 4 0 0.942 1.000 1.000 404 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CPOX(1), EPRS(2), FECH(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 16974408 27 24 25 8 2 4 4 12 5 0 0.625 1.000 1.000 405 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2) 10379706 13 12 13 6 1 2 1 8 1 0 0.797 1.000 1.000 406 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(3), FASN(3), OXSM(1) 9684314 11 11 11 5 1 0 4 5 1 0 0.827 1.000 1.000 407 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1) 15916381 23 22 22 8 4 3 4 7 5 0 0.676 1.000 1.000 408 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(1), EDNRB(1), EGF(4), EGFR(7), HRAS(1), JUN(2), MYC(1), NFKB1(1), RELA(1) 12588662 20 20 19 8 1 3 4 9 3 0 0.802 1.000 1.000 409 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2D6(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3) 17764358 32 29 32 9 4 9 1 15 3 0 0.296 1.000 1.000 410 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(1), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HGD(1), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(4), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(1), TPO(3), TYR(3), TYRP1(1) 36430512 74 62 73 15 5 8 13 34 14 0 0.201 1.000 1.000 411 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), ATF2(1), CALM2(1), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MEF2A(2), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1) 20918023 41 38 40 10 5 9 6 17 4 0 0.318 1.000 1.000 412 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(1), DUSP4(1), DUSP9(1), EIF4E(1), GRB2(1), MAPK3(1), MKNK1(1), MKNK2(1), NFKB1(1), RAP1A(1), RPS6KA1(2), SHC1(2), SOS1(6), SOS2(1), TRAF3(1) 18245304 24 24 24 7 3 3 3 13 2 0 0.606 1.000 1.000 413 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(3), AKT3(2), CCL3(1), CD86(1), CHUK(1), CXCL11(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IKBKE(2), IRAK1(3), IRAK4(1), JUN(2), LBP(1), LY96(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(1), RIPK1(1), SPP1(2), STAT1(4), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(2), TLR8(4), TLR9(1), TRAF3(1), TRAF6(1) 54642634 104 91 96 17 9 21 12 54 8 0 0.00543 1.000 1.000 414 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2A1(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), DAXX(4), FAS(1), FASLG(1), IKBKE(2), LTA(1), NFKB1(1), NGFR(1), NTRK1(4), PTPN13(7), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1) 26758848 35 34 35 8 2 5 4 18 6 0 0.398 1.000 1.000 415 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1) 15100204 24 23 24 9 2 4 4 11 2 1 0.736 1.000 1.000 416 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLB(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLG(2), POLG2(4), POLH(4), POLI(5), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM1(2), PRIM2(5), REV1(1), REV3L(2), RFC5(1) 25562950 47 44 45 10 4 3 4 21 12 3 0.485 1.000 1.000 417 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), LMNB1(1), PRF1(1) 11766669 14 14 14 5 0 4 2 7 1 0 0.724 1.000 1.000 418 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DLST(1), DOT1L(2), ECHS1(2), EHHADH(3), EHMT1(1), EHMT2(3), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SHMT1(2), SHMT2(3), TMLHE(1) 21926674 44 39 44 11 4 8 4 16 12 0 0.356 1.000 1.000 419 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(7), ELK1(1), GNAS(4), GNB1(2), GRB2(1), HRAS(1), ITGB1(3), KLK2(1), MAPK3(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(3), RPS6KA1(2), SHC1(2), SOS1(6), SRC(2), STAT3(1) 20205250 50 47 49 13 4 10 6 25 5 0 0.342 1.000 1.000 420 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(1), BTG1(2), CBX3(1), CLOCK(1), EIF4G2(3), ETV6(1), HERPUD1(1), HSPA8(6), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(7) 22468697 52 46 52 12 1 8 10 19 13 1 0.270 1.000 1.000 421 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), CBL(1), CFLAR(1), E2F1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(4), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KB1(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1) 21772478 51 49 48 13 4 13 6 19 9 0 0.241 1.000 1.000 422 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), JUN(2), LMNB1(1), MADD(4), MAP3K1(5), MAP3K7(1), PAK1(1), PRKDC(7), RB1(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1) 24293467 33 32 32 8 1 6 4 13 9 0 0.466 1.000 1.000 423 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3) 14822445 19 19 19 8 3 2 2 10 2 0 0.754 1.000 1.000 424 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(2), CFLAR(1), JUN(2), MAP3K7(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1) 16105509 18 18 18 8 0 5 3 7 3 0 0.803 1.000 1.000 425 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(10), SCARB1(2) 16773628 23 23 23 8 2 4 3 10 4 0 0.761 1.000 1.000 426 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), HADHB(2), RDH11(3), SLC27A5(2), SOAT2(3) 19572845 27 26 26 9 3 3 2 14 5 0 0.767 1.000 1.000 427 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), GAS2(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFSF10(1), TRADD(1) 20635809 25 24 25 8 1 4 3 11 6 0 0.711 1.000 1.000 428 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(6), CALM2(1), EP300(6), HDAC1(2), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1) 14635976 21 20 21 8 3 2 3 11 2 0 0.764 1.000 1.000 429 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1) 13158828 23 22 23 8 2 4 3 12 2 0 0.729 1.000 1.000 430 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(2), ARHGEF11(3), CDC42(1), DLG4(1), GNA13(4), LPA(2), MAP3K1(5), MAP3K5(5), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(1) 30052384 54 49 54 11 2 6 6 28 12 0 0.239 1.000 1.000 431 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(2), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(2), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2) 31896980 57 49 53 12 4 16 6 24 7 0 0.0641 1.000 1.000 432 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(4), DARS(1), EPRS(2), HARS(1), IARS(4), KARS(1), LARS(3), LARS2(1), MARS(2), MARS2(3), SARS(3), TARS(2), WARS2(1), YARS(1) 19909360 30 28 29 9 0 4 5 16 5 0 0.659 1.000 1.000 433 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1A2(1), EEF1D(1), EEF1G(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(20), PABPC3(11), PAIP1(2), SLC35A4(2) 27332007 75 66 67 19 7 14 9 27 18 0 0.342 1.000 1.000 434 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(1), ELK1(1), GAB1(1), GRB2(1), HGF(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAP4K1(1), MAPK3(1), MET(3), PAK1(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), PTK2B(2), PTPN11(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(1) 27908220 71 62 68 18 3 18 4 24 21 1 0.416 1.000 1.000 435 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5M(2), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2) 35180639 55 52 55 11 2 10 11 19 13 0 0.0717 1.000 1.000 436 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(6), ASAH1(1), DLG4(1), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PITX2(1), RAC1(1), RHO(1), RYR1(11) 28105820 42 39 42 10 7 6 6 19 4 0 0.182 1.000 1.000 437 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(1), BTK(1), CAD(4), CASP10(3), CASP8AP2(4), CD7(3), CSNK1A1(1), DAXX(4), DEDD(2), EGFR(7), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(3), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TP53(10), TPX2(1) 45034795 89 75 87 18 8 8 9 44 19 1 0.152 1.000 1.000 438 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(6), AXIN1(2), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(1), GSK3A(2), LRP1(10), MVP(3), NKD1(2), NKD2(1), PTPRA(1), SFRP1(2), WIF1(1) 24960163 47 45 46 12 4 8 7 21 7 0 0.375 1.000 1.000 439 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), DUSP10(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(9), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(2), MAPKAPK5(1), MKNK1(1), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1) 20630113 45 40 40 13 5 6 0 26 8 0 0.599 1.000 1.000 440 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(3), BDKRB1(1), BDKRB2(1), C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C3AR1(1), C4BPA(2), C5(4), C7(2), C8B(2), C8G(1), CD55(1), CFB(1), CFH(5), CR1(7), CR2(1), F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(4), PLAUR(3), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(6) 55525696 105 93 105 21 8 17 9 54 17 0 0.0747 1.000 1.000 441 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(9), B3GALT4(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(2), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), SLC36A2(1), TSPAN9(1), UBC(2) 32558147 61 56 60 13 5 5 15 25 11 0 0.140 1.000 1.000 442 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ALG6(1), CCKBR(2), CCR5(3), CELSR1(7), CELSR2(6), CELSR3(4), CHRM2(2), CHRM3(2), CIDEB(1), EMR2(2), EMR3(5), GPR116(3), GPR133(2), GPR17(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(2), LPHN2(2), LPHN3(7), NTSR1(1), OR8G1(2), OR8G2(2), P2RY11(1), P2RY13(1), PTGFR(2), SMO(3) 39661521 73 60 71 16 9 14 6 33 11 0 0.0725 1.000 1.000 443 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(9), DIAPH1(1), FYN(1), GSN(1), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(12), PIK3R1(2), PTK2(1), ROCK1(4), SHC1(2), SRC(2), TLN1(4) 23047889 52 49 47 14 4 14 6 19 8 1 0.366 1.000 1.000 444 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(2), BRAF(1), CREBBP(4), EGR1(2), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(3), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(4), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTPN11(1), SHC1(2), SRC(2), TH(1) 31430907 57 51 54 15 6 14 5 24 8 0 0.259 1.000 1.000 445 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(1), CHUK(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(9), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK9(2), MAPKAPK2(2), MAPKAPK5(1), MAX(3), MEF2A(2), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(1), PAK1(1), RAC1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KB1(1), RPS6KB2(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1) 59454728 105 89 99 20 14 10 8 50 23 0 0.0871 1.000 1.000 446 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), LPA(2), PLAT(2), PLAU(4), PLG(5), SERPINF2(2), VWF(6) 21610381 41 41 41 12 2 3 8 19 9 0 0.551 1.000 1.000 447 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(2), ASAH1(1), BRAF(1), DRD2(1), EGFR(7), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PIK3CB(1), PITX2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT3(1) 36079091 60 53 59 14 7 11 8 28 6 0 0.136 1.000 1.000 448 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(2), MIOX(2), OCRL(1), PI4KA(8), PI4KB(1), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5) 45816746 97 84 93 22 5 15 8 34 34 1 0.285 1.000 1.000 449 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNAI1(1), GNB1(2), GRB2(1), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(1), MYLK(4), PTK2B(2), SHC1(2), SOS1(6), STAT1(4), STAT3(1), SYT1(1) 25864845 44 41 44 12 4 6 6 23 5 0 0.464 1.000 1.000 450 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(1), CR2(1), CSK(2), GRB2(1), GSK3A(2), INPP5D(1), ITPR1(2), ITPR2(8), ITPR3(3), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), PPP3CA(1), PPP3CC(1), PTPRC(6), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2) 45144059 74 64 71 16 6 18 8 32 10 0 0.0522 1.000 1.000 451 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(4), CD19(1), CD22(1), CHUK(1), CR2(1), HRAS(1), INPP5D(1), JUN(2), KRAS(1), LILRB3(4), MALT1(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIB(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(4) 45555185 86 80 81 20 2 19 11 42 12 0 0.180 1.000 1.000 452 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JAK2(5), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KA1(2), SHC1(2), SLC2A4(1), SOS1(6), SRF(1), STAT5B(1) 20117940 45 42 42 13 4 11 7 20 3 0 0.340 1.000 1.000 453 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(1), ARHGAP5(9), ARHGAP6(1), ARHGEF1(1), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(1), CFL1(1), DIAPH1(1), GSN(1), MYL2(1), MYLK(4), OPHN1(1), PIP5K1A(2), ROCK1(4), SRC(2), TLN1(4), VCL(2) 28107592 44 41 41 11 1 8 6 19 9 1 0.385 1.000 1.000 454 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), CPEB1(3), EGFR(7), ERBB2(4), ERBB4(6), ETV6(1), FMN2(13), GRB2(1), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(9), NOTCH3(6), NOTCH4(1), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), SOS1(6), SOS2(1), SPIRE1(1), SPIRE2(2) 30577295 77 71 73 21 8 9 8 34 18 0 0.657 1.000 1.000 455 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASS1(2), CAD(4), CRAT(1), DARS(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHA2(1), PDHB(1) 23391226 38 32 38 11 2 2 9 12 13 0 0.573 1.000 1.000 456 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(3), F5(4), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), PROC(4), PROS1(4), SERPING1(2) 27873892 46 43 46 14 4 12 3 19 8 0 0.478 1.000 1.000 457 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADM(1), ACADS(2), ACOX1(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1) 30408563 43 43 41 12 5 6 8 16 8 0 0.410 1.000 1.000 458 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(5), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(1) 50635943 80 71 76 18 2 17 13 28 17 3 0.0958 1.000 1.000 459 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ADC(1), ALDH4A1(1), CAD(4), CPS1(6), EPRS(2), GAD2(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(2), GOT1(3), GOT2(2), GPT(1), GPT2(1), GSR(1), GSS(1), NAGK(2) 24484622 35 31 35 10 2 4 7 15 7 0 0.574 1.000 1.000 460 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2) 30345000 45 40 42 12 4 11 5 19 6 0 0.239 1.000 1.000 461 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DAK(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GK2(1), GLB1(4), GPAM(1), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2) 36385524 50 46 49 13 5 8 8 19 10 0 0.372 1.000 1.000 462 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(4), ALAS2(3), BLVRA(1), COX15(1), CPOX(1), EPRS(2), FECH(2), FTMT(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 26178342 49 45 46 14 3 7 7 25 7 0 0.517 1.000 1.000 463 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(9), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), CTNNB1(1), DIAPH1(1), DOCK1(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), FARP2(2), FIGF(3), FLNA(3), FLNB(2), FLNC(4), FLT1(4), FN1(4), FYN(1), GRB2(1), GRLF1(6), HGF(1), HRAS(1), IBSP(1), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), JUN(2), KDR(5), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), MAPK10(1), MAPK3(1), MAPK9(2), MET(3), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARVG(1), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(1), PRKCG(1), PTEN(20), PTK2(1), RAC1(1), RAC3(1), RAP1A(1), RAPGEF1(2), RELN(3), ROCK1(4), ROCK2(3), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SPP1(2), SRC(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TLN1(4), TLN2(6), TNC(5), TNN(3), TNR(8), TNXB(2), VAV1(2), VAV2(4), VCL(2), VTN(1), VWF(6), ZYX(1) 227635775 431 254 423 142 39 67 52 179 92 2 0.818 1.000 1.000 464 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(4), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ATF2(1), ATF4(2), BRAF(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(7), CACNA1H(3), CACNA1I(4), CACNA1S(7), CACNA2D1(3), CACNA2D2(1), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC42(1), CHUK(1), DAXX(4), DUSP10(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(7), ELK1(1), ELK4(1), FAS(1), FASLG(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(6), FGFR4(3), FLNA(3), FLNB(2), FLNC(4), GNG12(1), GRB2(1), HRAS(1), IL1R1(1), JUN(2), KRAS(1), MAP2K3(9), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(2), MAPKAPK5(1), MAPT(1), MAX(3), MKNK1(1), MKNK2(1), MRAS(1), MYC(1), NF1(7), NFATC2(1), NFATC4(4), NFKB1(1), NR4A1(1), NTRK1(4), PAK1(1), PDGFRA(7), PDGFRB(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAP1A(1), RAPGEF2(6), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA6(1), SOS1(6), SOS2(1), SRF(1), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TP53(10), TRAF6(1), ZAK(1) 178314331 325 223 315 89 32 40 37 149 67 0 0.372 1.000 1.000 465 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(3), ADCY3(3), ADCY7(1), ADCY8(6), ADCY9(3), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), ATP2A1(6), ATP2A2(4), ATP2B1(1), ATP2B2(1), ATP2B3(1), ATP2B4(1), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(7), CACNA1H(3), CACNA1I(4), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(7), ERBB2(4), ERBB3(3), ERBB4(6), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(4), GRM1(4), GRM5(4), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(1), PDE1A(1), PDE1B(2), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTAFR(1), PTGFR(2), PTK2B(2), RYR1(11), RYR2(10), RYR3(11), SLC25A4(2), SLC25A5(3), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), TRHR(2), TRPC1(1) 167992818 302 219 299 94 43 39 27 142 51 0 0.497 1.000 1.000 466 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), APC(6), APC2(4), ARHGEF1(1), ARHGEF6(1), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(1), C3orf10(2), CDC42(1), CFL1(1), CHRM2(2), CHRM3(2), CHRM5(2), CSK(2), CYFIP1(4), CYFIP2(5), DIAPH1(1), DIAPH2(2), DIAPH3(3), DOCK1(1), EGF(4), EGFR(7), F2(3), FGD1(3), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(6), FGFR4(3), FN1(4), GIT1(2), GNA13(4), GNG12(1), GRLF1(6), GSN(1), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(1), LIMK2(2), MAPK3(1), MRAS(1), MSN(2), MYH14(3), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PPP1R12A(1), PTK2(1), RAC1(1), RAC3(1), RDX(1), ROCK1(4), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(6), SOS2(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(2), VAV1(2), VAV2(4), VCL(2), WASF2(1), WASL(6) 172722076 296 206 287 83 21 43 40 137 55 0 0.401 1.000 1.000 467 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), CHAD(2), COL11A1(9), COL11A2(2), COL17A1(3), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), DSC2(3), DSG1(3), DSG2(2), DSG3(1), DSG4(1), FN1(4), GJA1(2), GJA10(1), GJA3(1), GJA4(1), GJA5(3), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(7), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(1), KRT19(1), KRT2(3), KRT23(1), KRT24(2), KRT27(1), KRT28(1), KRT3(3), KRT31(1), KRT35(1), KRT36(2), KRT38(1), KRT4(4), KRT5(1), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(3), KRT77(1), KRT78(1), KRT79(2), KRT82(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), LMNB1(1), NES(5), PRPH(1), RELN(3), SPP1(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(5), TNN(3), TNR(8), TNXB(2), VTN(1), VWF(6) 150895233 289 203 281 110 30 38 31 114 76 0 0.987 1.000 1.000 468 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRA2B(2), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(2), CHRM2(2), CHRM3(2), CHRM5(2), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2(3), F2RL1(1), F2RL2(1), FPR1(1), GABBR1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(4), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA2(1), GLRB(1), GPR35(1), GPR50(3), GPR63(1), GPR83(1), GRIA1(4), GRIA2(3), GRIA4(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRIN3B(3), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM6(3), GRM7(1), GRM8(2), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), LEP(1), LEPR(1), MAS1(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(3), OPRM1(2), P2RX1(2), P2RX2(3), P2RX3(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), P2RY8(3), PARD3(2), PPYR1(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), THRA(2), TRHR(2), VIPR1(1) 133299208 243 181 239 75 37 39 20 108 39 0 0.401 1.000 1.000 469 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD44(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), FN1(4), FNDC1(2), FNDC3A(2), GP6(2), HMMR(1), HSPG2(8), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), RELN(3), SDC3(1), SPP1(2), SV2C(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(5), TNN(3), TNR(8), TNXB(2), VTN(1), VWF(6) 136421267 238 180 236 89 26 32 29 93 58 0 0.959 1.000 1.000 470 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(3), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(3), KRAS(1), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(4), MLLT4(5), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH11(6), MYH13(4), MYH14(3), MYH15(2), MYH2(7), MYH3(5), MYH4(6), MYH6(3), MYH7(2), MYH7B(4), MYH8(1), MYH9(2), MYL2(1), MYL7(1), MYL9(1), PARD3(2), PARD6A(2), PARD6B(3), PPM1J(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PTEN(20), SPTAN1(5), SRC(2), TJAP1(1), TJP1(2), TJP2(2), YES1(1), ZAK(1) 120418292 214 160 212 72 20 23 14 86 69 2 0.939 1.000 1.000 471 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ADRA1A(1), ADRB2(2), ANXA6(1), ATP1A4(3), ATP2A2(4), ATP2B1(1), ATP2B2(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1S(7), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM2(2), CHRM3(2), CHRM5(2), GJA1(2), GJA4(1), GJA5(3), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MYCBP(1), PKIA(1), PLCB3(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RYR1(11), RYR2(10), RYR3(11), SLC8A1(1), SLC8A3(3), USP5(1) 118094932 206 158 204 59 29 23 17 93 44 0 0.424 1.000 1.000 472 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL3(1), CCR5(3), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(2), CXCL11(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(7), FAS(1), FASLG(1), FLT1(4), FLT3(2), FLT4(6), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1R1(1), IL1RAP(4), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(2), IL28A(1), IL28B(2), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(3), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(3), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF14(2), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(3), XCL1(2), XCR1(1) 108952487 192 154 189 46 12 32 24 102 22 0 0.0988 1.000 1.000 473 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(3), ABLIM3(2), CDC42(1), CFL1(1), CXCR4(1), DCC(3), DPYSL2(2), EFNA3(1), EPHA1(3), EPHA3(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(1), EPHB4(3), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(4), LIMK2(2), MAPK3(1), MET(3), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NRP1(1), NTN4(2), NTNG1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(3), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(5), RND1(3), ROBO1(2), ROBO2(4), ROBO3(1), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6C(1), SEMA6D(2), SLIT1(1), SLIT2(3), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(2), UNC5C(1), UNC5D(2) 119700033 185 146 183 69 17 27 19 86 36 0 0.964 1.000 1.000 474 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), DGKZ(2), GABPA(1), GBA2(4), GJA1(2), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(8), NOS3(2), PDE4B(2), PDE4D(1), PKIA(1), PLCB3(1), PLCG2(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RLN1(1), RYR1(11), RYR2(10), RYR3(11), SLC8A1(1), TNXB(2), USP5(1) 106310346 179 145 177 53 23 24 16 82 34 0 0.642 1.000 1.000 475 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(3), ASH2L(2), CTCFL(1), DOT1L(2), EHMT1(1), EHMT2(3), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(2), JMJD4(1), JMJD6(4), KDM6A(4), MEN1(1), MLL(5), MLL2(14), MLL3(16), MLL4(4), MLL5(6), NSD1(4), OGT(4), PRDM2(3), PRDM6(1), PRDM7(2), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), RBBP5(3), SETD1A(2), SETD1B(1), SETD2(52), SETDB1(4), SETMAR(1), SUV39H2(3), SUZ12(5), WHSC1(2), WHSC1L1(5) 75331297 178 143 176 39 11 18 22 53 73 1 0.126 1.000 1.000 476 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(6), APC2(4), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(2), CREBBP(4), CSNK1A1(1), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(1), DAAM1(2), DKK2(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), JUN(2), LEF1(1), LRP5(2), LRP6(2), MAP3K7(1), MAPK10(1), MAPK9(2), MMP7(1), MYC(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SFRP1(2), SFRP4(4), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7(2), TCF7L2(1), TP53(10), VANGL1(1), VANGL2(1), WIF1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 97713874 175 141 170 54 14 15 27 84 35 0 0.738 1.000 1.000 477 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(2), CADM1(1), CADM3(1), CD22(1), CD28(1), CD34(1), CD4(2), CD6(2), CD86(1), CD99(1), CDH1(2), CDH2(5), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(5), CNTNAP2(4), ESAM(1), F11R(1), GLG1(4), HLA-A(4), HLA-B(5), HLA-C(2), HLA-DPA1(1), HLA-DPB1(2), HLA-DQB1(4), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), HLA-E(2), HLA-F(1), ITGA4(1), ITGA6(4), ITGA9(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(4), MADCAM1(4), MPZL1(1), NCAM1(2), NCAM2(2), NEGR1(2), NEO1(2), NFASC(4), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(3), PTPRC(6), PTPRF(3), PTPRM(3), PVRL2(2), PVRL3(2), SDC3(1), SELE(4), SELP(1), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(6) 88453477 184 140 177 80 14 26 28 86 30 0 0.990 1.000 1.000 478 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(3), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CALM2(1), CBL(1), CBLB(2), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FBP1(1), FOXO1(2), G6PC(2), GRB2(1), GYS1(1), GYS2(1), HRAS(1), INPP5D(1), INSR(3), IRS1(3), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(1), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(2), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPN1(1), PTPRF(3), PYGB(2), PYGL(1), PYGM(2), RAPGEF1(2), RHEB(4), RHOQ(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC3(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(5) 97539146 171 138 165 31 14 29 21 85 22 0 0.00404 1.000 1.000 479 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(2), AKT2(3), AKT3(2), CBL(1), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(4), CSF2RA(3), CSF2RB(1), CSF3R(2), EP300(6), GH2(1), GHR(1), GRB2(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL28A(1), IL28B(2), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(3), IRF9(2), JAK1(4), JAK2(5), JAK3(4), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(2), PIAS2(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS4(1), SOS1(6), SOS2(1), SPRED1(5), SPRED2(1), SPRY2(2), SPRY4(2), STAM(2), STAT1(4), STAT2(3), STAT3(1), STAT4(1), STAT5B(1), STAT6(4), TPO(3), TYK2(3) 89448315 172 135 167 46 9 32 28 81 22 0 0.247 1.000 1.000 480 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(3), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PFAS(1), PKM2(1), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(5), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(2) 101616272 152 127 148 36 10 23 15 66 35 3 0.226 1.000 1.000 481 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ATF4(2), CACNA1C(8), CACNA1D(4), CACNA1F(3), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), EGFR(7), ELK1(1), GNAS(4), GRB2(1), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), KRAS(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MMP14(1), MMP2(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLD1(2), PLD2(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCD(2), PTK2B(2), SOS1(6), SOS2(1), SRC(2) 80046947 153 121 148 46 21 20 14 78 20 0 0.513 1.000 1.000 482 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), ATM(15), ATR(5), BUB3(1), CCNA1(4), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDC14A(3), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(3), CDC7(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), CHEK2(3), CREBBP(4), CUL1(3), E2F1(1), EP300(6), ESPL1(7), FZR1(4), HDAC1(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(7), RB1(1), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), TP53(10), WEE1(1), YWHAE(1) 85002005 159 118 157 38 10 22 24 67 36 0 0.171 1.000 1.000 483 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN11(3), CAPN3(3), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(1), CSK(2), DOCK1(1), FYN(1), GIT2(1), GRB2(1), ILK(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K3(9), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), RAC1(1), RAC3(1), RAPGEF1(2), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(2), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(4), TNS1(5), VAV2(4), VCL(2), ZYX(1) 83668064 138 116 132 48 12 22 19 63 22 0 0.807 1.000 1.000 484 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ARHGAP5(9), BCAR1(3), CD99(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(4), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), VAV1(2), VAV2(4), VCAM1(1), VCL(2) 76843470 142 115 136 48 10 26 17 58 30 1 0.672 1.000 1.000 485 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR5(3), CCR6(1), CCR9(1), CHML(1), CHRM2(2), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2RL1(1), F2RL2(1), FPR1(1), GALR1(1), GALT(2), GPR17(1), GPR173(2), GPR174(2), GPR35(1), GPR37(1), GPR37L1(1), GPR4(1), GPR50(3), GPR63(1), GPR77(1), GPR83(1), GPR85(2), HCRTR2(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(3), OPRM1(2), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(3), OR8B8(2), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PPYR1(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RGR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2) 71443225 131 114 127 37 24 13 15 59 20 0 0.259 1.000 1.000 486 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(4), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), EGFR(7), EP300(6), ERBB2(4), FARP2(2), FGFR1(4), FYN(1), INSR(3), IQGAP1(5), LEF1(1), LMO7(4), MAP3K7(1), MAPK3(1), MET(3), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(3), PTPRJ(4), PTPRM(3), PVRL2(2), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7(2), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(1), WASF3(1), WASL(6), YES1(1) 74430827 138 114 136 39 11 15 24 67 21 0 0.480 1.000 1.000 487 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), DRD1(1), DRD2(1), EGF(4), EGFR(7), GJA1(2), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(1), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), NPR1(3), NPR2(2), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(2), SOS1(6), SOS2(1), SRC(2), TJP1(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1) 81467808 144 114 141 45 16 19 15 68 26 0 0.675 1.000 1.000 488 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(1), ARHGEF7(3), BCAR1(3), BRAF(1), CDC42(1), CDKN2A(5), CSE1L(2), DOCK1(1), EPHB2(1), FYN(1), GRB2(1), GRB7(2), GRLF1(6), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PLCG2(1), PTEN(20), PTK2(1), RHO(1), ROCK1(4), ROCK2(3), SHC1(2), SOS1(6), SOS2(1), SRC(2), TLN1(4), TLN2(6), ZYX(1) 75577526 149 114 146 38 10 31 15 59 33 1 0.194 1.000 1.000 489 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), OCRL(1), PI4KA(8), PI4KB(1), PIK3C2B(3), PIK3C2G(2), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PRKCG(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5) 77975305 132 109 126 36 9 23 11 51 37 1 0.374 1.000 1.000 490 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(3), ACTN3(1), ACTN4(1), DMD(5), FAM48A(1), MYBPC1(1), MYBPC2(3), MYBPC3(1), MYH3(5), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL2(1), MYL9(1), MYOM1(3), NEB(11), TMOD1(2), TNNI1(1), TNNT1(2), TNNT3(1), TPM2(1), TTN(76) 87431342 127 108 127 35 12 22 10 57 24 2 0.427 1.000 1.000 491 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), FYN(1), GRB2(1), HLA-A(4), HLA-B(5), HLA-C(2), HLA-E(2), HRAS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), ITGAL(4), ITGB2(1), KIR3DL1(1), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(2), MICB(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PAK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SYK(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(4) 68850097 129 107 123 51 5 27 20 60 17 0 0.950 1.000 1.000 492 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE6B(2), PDE6C(2), PDE8A(2), PFAS(1), PKM2(1), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1) 79097280 124 107 124 27 13 14 12 57 28 0 0.158 1.000 1.000 493 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), AKAP1(3), AKAP11(1), AKAP12(3), AKAP2(4), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(12), ARHGEF1(1), CALM2(1), CHMP1B(3), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKD3(2), SLC9A1(2), USP5(1) 72519872 133 105 130 32 12 18 5 65 33 0 0.345 1.000 1.000 494 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(4), CBL(1), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(1), FYN(1), GRAP2(1), GRB2(1), HRAS(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIB(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(3), PTPN6(3), PTPRC(6), SOS1(6), SOS2(1), TEC(5), VAV1(2), VAV2(4) 61999380 121 101 116 27 4 24 15 64 14 0 0.160 1.000 1.000 495 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), ENPP3(1), EP400(5), ERCC2(1), ERCC3(1), G6PC(2), GAA(1), GANC(1), GBA(2), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), IFIH1(2), MGAM(4), MOV10L1(3), PYGB(2), PYGL(1), PYGM(2), RAD54L(2), RUVBL2(2), SETX(5), SI(6), SMARCA2(4), SMARCA5(1), TREH(2), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), UXS1(1) 77200858 122 100 118 41 5 20 21 46 30 0 0.755 1.000 1.000 496 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(5), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(1), GRIA1(4), GRIA2(3), GRID2(4), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(3), NPR2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCG(1), PRKG1(2), PRKG2(2), RYR1(11) 68427272 115 100 115 44 17 13 11 55 19 0 0.906 1.000 1.000 497 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(15), BUB3(1), CCNA1(4), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDAN1(5), CDC14A(3), CDC20(1), CDC25A(1), CDC25C(2), CDC7(1), CDH1(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CHEK2(3), E2F1(1), E2F5(1), EP300(6), ESPL1(7), HDAC1(2), HDAC4(1), HDAC6(4), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(7), PTPRA(1), RB1(1), SKP2(1), SMAD4(1), TBC1D8(1), TP53(10), WEE1(1) 68936071 127 99 123 35 9 21 24 49 24 0 0.260 1.000 1.000 498 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(2), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), ERBB3(3), ERBB4(6), GAB1(1), GRB2(1), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NRG1(4), NRG2(2), NRG3(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SRC(2), STAT5B(1) 63099338 119 99 114 29 9 28 14 57 11 0 0.116 1.000 1.000 499 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(4), AKT1(2), AURKB(1), BMPR2(4), CDS2(1), CLK1(4), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A2(1), CSNK2B(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PAK4(2), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1), PLK3(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKG1(2), RPS6KA1(2), RPS6KB1(1), STK11(1) 70509482 115 98 110 30 8 24 7 51 25 0 0.313 1.000 1.000 500 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(4), ABCA12(7), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(5), ABCA5(6), ABCA6(1), ABCA7(6), ABCA8(3), ABCA9(2), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(3), ABCB6(1), ABCC1(2), ABCC10(3), ABCC11(1), ABCC12(3), ABCC2(1), ABCC3(7), ABCC4(3), ABCC5(6), ABCC6(4), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(3), ABCG5(1), ABCG8(2), CFTR(4) 72984357 121 94 119 39 6 20 17 60 17 1 0.655 1.000 1.000 501 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(1), DCT(4), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), TCF7(2), TCF7L2(1), TYR(3), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 65676689 108 93 107 30 9 10 13 58 18 0 0.495 1.000 1.000 502 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(1), ALG8(2), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT3(1), B4GALT4(2), B4GALT5(1), CHST1(1), CHST11(1), CHST12(1), CHST4(1), CHST7(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST5(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST2(2), NDST4(3), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2) 66116349 106 92 106 35 4 20 14 46 22 0 0.773 1.000 1.000 503 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(4), ACVR1C(1), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMP8B(1), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(3), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), MYC(1), PITX2(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMAD9(1), SMURF2(3), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(6), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(4) 60246080 106 92 105 28 5 10 15 54 22 0 0.505 1.000 1.000 504 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(6), ATF4(2), BRAF(1), CACNA1C(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(4), EP300(6), GRIA1(4), GRIA2(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRM1(4), GRM5(4), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAP1A(1), RAPGEF3(2), RPS6KA1(2), RPS6KA6(1) 62722718 103 90 103 24 13 14 10 53 13 0 0.137 1.000 1.000 505 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 CABIN1(6), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(1), EGR3(1), EP300(6), GATA4(1), GRLF1(6), GSK3A(2), HRAS(1), IFNA1(2), IFNB1(2), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(2), MEF2D(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKBIB(1), NPPB(1), NUP214(2), OPRD1(3), PAK1(1), PPP3CC(1), PTPRC(6), RELA(1), SP3(1), TRPV6(4), VAV1(2), VAV2(4), XPO5(2) 55354822 100 88 99 26 8 15 14 48 15 0 0.312 1.000 1.000 506 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(6), CD19(1), CD1D(3), CD1E(1), CD22(1), CD24(1), CD33(1), CD34(1), CD38(1), CD3E(2), CD3G(1), CD4(2), CD44(1), CD55(1), CD7(3), CR1(7), CR2(1), CSF1R(5), CSF2RA(3), CSF3R(2), DNTT(2), FLT3(2), GYPA(1), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), IL1R1(1), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL9R(3), ITGA1(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(3), ITGB3(1), KIT(3), KITLG(2), MME(3), TPO(3) 50449603 107 88 104 27 8 9 20 50 19 1 0.353 1.000 1.000 507 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK2(2), CLK4(2), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(2), CPSF4(2), CSTF2T(1), CSTF3(3), DDX1(1), DDX20(4), DHX15(3), DHX8(1), DHX9(4), DICER1(2), FUS(4), LSM7(1), METTL3(4), NONO(2), NUDT21(2), NXF1(1), PABPN1(1), PAPOLA(3), POLR2A(6), PRPF3(1), PRPF4B(1), PRPF8(7), PSKH1(2), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(1), SNRPN(2), SRPK2(2), SRRM1(1), SUPT5H(5), TXNL4A(1), U2AF2(1), XRN2(3) 65315822 105 87 104 29 4 25 10 45 20 1 0.414 1.000 1.000 508 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(1), GAB2(1), GRB2(1), HRAS(1), IL3(1), IL4(1), INPP5D(1), KRAS(1), LCP2(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCD(2), PRKCE(4), RAC1(1), RAC3(1), SOS1(6), SOS2(1), SYK(1), VAV1(2), VAV2(4) 44675958 87 77 78 29 10 18 11 40 8 0 0.581 1.000 1.000 509 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(15), CCNA1(4), CCND2(1), CCNE1(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(1), E2F5(1), GBA2(4), MCM2(3), MCM5(1), MCM6(2), MCM7(4), MYC(1), MYT1(2), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(1), RPA2(1), RPA3(1), TFDP2(5), TNXB(2), TP53(10), WEE1(1) 46187944 91 73 91 25 6 11 12 40 22 0 0.506 1.000 1.000 510 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(2), CHUK(1), CPT1A(1), G6PC(2), IRS1(3), IRS4(1), JAK1(4), JAK2(5), JAK3(4), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), PPARGC1A(3), PRKAG1(1), PRKAG2(4), PRKCQ(3), PTPN11(1), RELA(1), RXRB(3), RXRG(2), SLC2A4(1), STAT3(1), STK11(1), TNFRSF1A(1), TRADD(1), TYK2(3) 49830098 80 73 80 22 3 15 12 34 16 0 0.443 1.000 1.000 511 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(3), AKT3(2), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NOS3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCG(1), PTGS2(4), PTK2(1), RAC1(1), RAC3(1), SHC2(1), SPHK2(1), SRC(2) 44021378 82 72 76 30 4 17 10 40 11 0 0.778 1.000 1.000 512 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(2), CTSB(3), CTSL1(2), CTSS(1), HLA-A(4), HLA-B(5), HLA-C(2), HLA-DPA1(1), HLA-DPB1(2), HLA-DQB1(4), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), KIR2DS4(1), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), RFX5(1) 25594534 86 71 80 34 7 12 12 38 17 0 0.945 1.000 1.000 513 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CREBBP(4), EHHADH(3), EP300(6), FABP1(1), HSD17B4(1), JUN(2), LPL(1), MAPK3(1), ME1(1), MYC(1), NCOA1(2), NCOR1(5), NCOR2(4), NR1H3(1), NRIP1(6), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTGS2(4), RB1(1), RELA(1), SRA1(3), STAT5B(1) 38546269 73 68 69 19 4 17 11 37 4 0 0.191 1.000 1.000 514 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(5), CPT1A(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(3), FABP1(1), FADS2(2), GK2(1), HMGCS2(1), ILK(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(1), RXRB(3), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(1), UBC(2), UCP1(1) 39806181 74 66 72 26 5 10 15 31 13 0 0.761 1.000 1.000 515 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(4), GLI3(3), HHIP(2), LRP2(13), PRKACA(1), PRKACB(4), PRKACG(2), PTCH1(7), PTCH2(1), SHH(1), SMO(3), STK36(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 35583288 68 61 66 21 6 8 8 39 7 0 0.711 1.000 1.000 516 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DLST(1), DOT1L(2), ECHS1(2), EHHADH(3), EHMT1(1), EHMT2(3), HADH(1), HADHA(1), HSD17B4(1), NSD1(4), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(3), SETD1A(2), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(3), TMLHE(1) 34935687 67 59 67 19 6 14 9 23 15 0 0.382 1.000 1.000 517 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(2), DVL1(1), EP300(6), HDAC1(2), JAG1(1), JAG2(2), MAML1(4), MAML2(2), MAML3(5), NCOR2(4), NCSTN(1), NOTCH1(5), NOTCH2(9), NOTCH3(6), NOTCH4(1), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1) 40444145 71 59 71 31 7 7 14 30 13 0 0.943 1.000 1.000 518 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), EP400(5), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(5), SMARCA2(4), SMARCA5(1) 38574277 66 58 66 19 1 18 10 21 16 0 0.357 1.000 1.000 519 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(4), ATP4A(3), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA4L2(2), NDUFA6(1), NDUFA7(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC2(1), UQCRFS1(3) 34655460 60 56 57 23 5 6 11 26 12 0 0.922 1.000 1.000 520 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(4), EGF(4), EGFR(7), HRAS(1), JUN(2), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), RELA(1), RIPK1(1), TNFRSF1A(1) 30112622 61 56 55 20 8 5 3 29 16 0 0.827 1.000 1.000 521 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(6), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), FZD1(2), FZD10(2), FZD3(1), FZD5(1), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(4), TCF7(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1) 35605677 61 56 58 22 5 11 6 28 11 0 0.791 1.000 1.000 522 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(2), CD3G(1), ELK1(1), FYN(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RASA1(3), RELA(1), SHC1(2), SOS1(6), SYT1(1), VAV1(2) 28912835 59 55 56 17 5 16 7 24 7 0 0.405 1.000 1.000 523 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(4), B3GALT2(2), B3GALT4(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), B4GALT6(1), FUT1(1), FUT6(3), GBGT1(2), GCNT2(4), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(2), ST8SIA1(2), ST8SIA5(1) 29538729 57 54 54 17 5 8 8 19 16 1 0.670 1.000 1.000 524 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CFLAR(1), CHUK(1), DAXX(4), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(5), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(2), PRKCD(2), PRKDC(7), PSEN2(3), PTK2(1), RASA1(3), RB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1) 42948439 61 52 60 20 2 15 7 26 11 0 0.703 1.000 1.000 525 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(3), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GALM(2), GAPDHS(1), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TPI1(1) 35889358 59 52 58 19 4 5 7 25 18 0 0.817 1.000 1.000 526 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), CDC42(1), CHUK(1), CSK(2), EGFR(7), F11R(1), GIT1(2), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(3), NFKB1(1), NOD1(2), PAK1(1), PLCG2(1), PTPN11(1), PTPRZ1(8), RAC1(1), RELA(1), SRC(2), TJP1(2) 43767104 62 52 61 20 3 11 9 30 9 0 0.775 1.000 1.000 527 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), DDC(2), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), TPH1(1), TPH2(1), WARS2(1) 37332426 58 51 58 16 4 11 9 25 9 0 0.505 1.000 1.000 528 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(1), CPS1(6), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(1), NOS1(8), NOS3(2), ODC1(1), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2) 27134161 55 49 55 20 2 4 13 25 11 0 0.841 1.000 1.000 529 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(5), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PIK3CA(12), PIK3R1(2), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2) 25935673 52 49 49 16 5 12 6 22 7 0 0.497 1.000 1.000 530 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BID(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), CHUK(1), FAS(1), FASLG(1), HELLS(2), JUN(2), LTA(1), MAP3K1(5), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TP73(3), TRADD(1), TRAF3(1) 34651207 49 48 49 15 2 8 7 22 10 0 0.588 1.000 1.000 531 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(2), GAA(1), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), MGAM(4), PYGB(2), PYGL(1), PYGM(2), RNPC3(2), SI(6), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1) 35652492 55 48 52 15 4 6 11 21 13 0 0.456 1.000 1.000 532 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 31677284 53 47 53 28 4 12 9 22 6 0 0.981 1.000 1.000 533 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 31677284 53 47 53 28 4 12 9 22 6 0 0.981 1.000 1.000 534 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), CARS(4), CARS2(2), DARS(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), KARS(1), LARS(3), LARS2(1), MARS(2), MARS2(3), NARS2(4), PARS2(2), SARS(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS2(1), YARS(1) 32597040 49 46 48 13 1 9 6 25 8 0 0.457 1.000 1.000 535 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1C1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), MGST3(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 35849687 54 46 52 19 5 6 8 22 13 0 0.829 1.000 1.000 536 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2D6(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(3), HADHA(1), MAOA(1), TPH1(1), WARS2(1) 33897692 54 46 54 20 4 10 7 26 7 0 0.807 1.000 1.000 537 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR5(3), CCR6(1), CXCR4(1), CXCR6(1), EDNRB(1), FPR1(1), GALR1(1), GALT(2), GPR77(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(3), OPRM1(2), PPYR1(2), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2) 31235819 52 45 50 16 13 5 5 24 5 0 0.358 1.000 1.000 538 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CSK(2), EPHB2(1), FBXW7(1), GRAP2(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(2), LCP2(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PTPRC(6), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(1), VAV1(2) 34244885 51 45 50 17 6 9 4 25 7 0 0.735 1.000 1.000 539 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(2), FYN(1), GRB2(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAPK3(1), PTK2(1), RAP1A(1), ROCK1(4), SHC1(2), SOS1(6), SRC(2), TLN1(4), VCL(2), ZYX(1) 28961613 48 44 48 15 5 8 2 24 9 0 0.737 1.000 1.000 540 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CREBBP(4), EP300(6), ERCC3(1), GTF2A1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(4), NCOR2(4), NRIP1(6), PELP1(1), POLR2A(6), SRA1(3), TBP(1) 28772970 47 43 45 19 0 9 10 22 6 0 0.751 1.000 1.000 541 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLD1(3), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBC(2) 31494222 47 43 47 18 3 6 6 22 10 0 0.833 1.000 1.000 542 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GAPDHS(1), GOT1(3), GOT2(2), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TNFAIP1(1), TPI1(1) 26101135 48 43 48 16 2 4 6 17 19 0 0.808 1.000 1.000 543 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(7), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 30876617 48 43 46 16 5 5 6 22 10 0 0.783 1.000 1.000 544 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(3), ACSS1(3), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1) 28772098 47 43 47 15 0 7 10 15 15 0 0.726 1.000 1.000 545 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT6(1), CDS2(1), CHKB(1), CHPT1(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(1), LCAT(1), LYPLA1(1), MYST3(4), MYST4(4), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(1) 40535957 47 42 47 11 6 5 9 22 5 0 0.239 1.000 1.000 546 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(3), ACADM(1), ACSS1(3), ACSS2(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(3), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1) 24582680 43 42 43 15 2 5 12 14 10 0 0.773 1.000 1.000 547 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), ATP7A(3), ATP7B(5), COX6A2(1), COX7A2(1), NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRFS1(3) 23852880 43 42 40 16 2 7 9 17 8 0 0.836 1.000 1.000 548 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1) 30105215 47 41 46 18 4 2 5 22 14 0 0.933 1.000 1.000 549 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1) 30105215 47 41 46 18 4 2 5 22 14 0 0.933 1.000 1.000 550 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), ELK1(1), FPR1(1), GNA15(1), GNB1(2), HRAS(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(1), SYT1(1) 23572453 46 40 42 15 8 5 3 21 9 0 0.692 1.000 1.000 551 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ASL(1), ASS1(2), CPS1(6), DAO(1), EPRS(2), GATM(2), GOT1(3), GOT2(2), LAP3(2), NOS1(8), NOS3(2), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(2), PRODH(1), PYCR1(1), PYCR2(1) 22160264 43 40 43 16 2 3 11 19 8 0 0.807 1.000 1.000 552 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GPX6(1), LTA4H(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1) 24062020 43 40 42 17 6 5 10 16 6 0 0.713 1.000 1.000 553 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 20081807 41 39 41 15 1 6 8 20 6 0 0.845 1.000 1.000 554 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), STAT1(4), STAT3(1), STAT5B(1) 18406087 41 39 38 12 3 10 4 21 3 0 0.504 1.000 1.000 555 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), FAS(1), FASLG(1), JUN(2), MAP3K1(5), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(2), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1) 22678554 39 37 39 15 2 8 7 15 7 0 0.811 1.000 1.000 556 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), ADC(1), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(1), ASS1(2), CPS1(6), GATM(2), MAOA(1), ODC1(1), OTC(1), SAT1(1), SAT2(1), SMS(2) 18081719 38 37 38 13 0 5 8 19 6 0 0.805 1.000 1.000 557 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(2), MIOX(2), OCRL(1), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1) 27910396 43 37 39 16 2 8 3 20 10 0 0.884 1.000 1.000 558 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2) 16944584 38 36 35 14 1 10 4 16 7 0 0.765 1.000 1.000 559 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GLB1(4), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PPAP2B(1), PPAP2C(2) 29842836 39 36 38 14 5 8 4 15 7 0 0.728 1.000 1.000 560 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(4), CLYBL(2), CS(2), DLD(2), DLST(1), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), OGDHL(2), PC(1), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1) 18584106 39 36 39 14 4 5 4 18 8 0 0.815 1.000 1.000 561 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(1), GMPPB(1), HK1(4), KHK(4), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(2), PGM2(2), PMM1(1), RDH11(3), SORD(2), TPI1(1) 23117498 37 36 37 13 5 3 6 14 9 0 0.726 1.000 1.000 562 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(1), ALG6(1), ALG8(2), B4GALT3(1), DOLPP1(2), DPAGT1(2), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), RPN2(1), STT3B(2) 25918113 37 36 37 13 0 8 1 18 10 0 0.843 1.000 1.000 563 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), AR(1), ESR2(1), ESRRA(2), NR1D2(1), NR1H3(1), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(2), PGR(1), PPARD(1), PPARG(1), RARA(4), RARB(2), RORA(1), RXRB(3), RXRG(2), THRA(2), VDR(1) 24907020 39 36 38 12 3 3 11 13 9 0 0.673 1.000 1.000 564 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(9), MAP3K1(5), MAPK14(1), MAPK3(1), PAK1(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1) 17464944 39 36 35 16 7 7 1 20 4 0 0.882 1.000 1.000 565 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), ILK(1), POLR1A(3), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TBP(1) 21473327 37 36 35 11 0 8 4 16 9 0 0.500 1.000 1.000 566 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), RAC1(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2) 23043913 38 35 38 19 5 6 4 17 6 0 0.962 1.000 1.000 567 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(7), ARSE(1), ASAH1(1), B4GALT6(1), DEGS1(2), ENPP7(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(1), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2) 21162933 38 35 36 17 6 5 5 15 7 0 0.909 1.000 1.000 568 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(1), GRB2(1), HRAS(1), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SOS1(6), SRF(1) 14889071 36 35 33 12 3 13 3 15 2 0 0.502 1.000 1.000 569 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CALM2(1), ELK1(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1) 20771360 35 34 35 13 5 4 2 19 5 0 0.861 1.000 1.000 570 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(3), GAD2(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), RDH11(3) 25117682 36 34 35 13 5 4 5 14 8 0 0.790 1.000 1.000 571 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1) 22738541 38 34 38 12 0 5 7 14 12 0 0.719 1.000 1.000 572 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1) 20524915 34 33 34 12 2 3 9 13 7 0 0.767 1.000 1.000 573 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(7), MYC(1), POLR2A(6), PPP2CA(1), RB1(1), TEP1(2), TERT(4), TNKS(1), TP53(10), XRCC5(2) 17383824 37 33 36 12 5 8 7 12 5 0 0.389 1.000 1.000 574 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GANC(1), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(4), PFKL(1), PFKM(2), RDH11(3), UGP2(1) 23600941 35 32 34 12 3 3 6 16 7 0 0.711 1.000 1.000 575 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 ELK1(1), GRB2(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(4), JUN(2), MAPK3(1), PTPN11(1), SHC1(2), SOS1(6), SRF(1), STAT3(1) 14453573 33 32 33 12 2 4 5 17 5 0 0.860 1.000 1.000 576 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RASAL1(1), SRC(2), TEC(5), VAV1(2) 16974757 30 29 29 12 2 3 5 15 5 0 0.890 1.000 1.000 577 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), RELA(1) 17319856 30 28 27 15 1 10 3 13 3 0 0.906 1.000 1.000 578 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(2), DLAT(2), DLD(2), DLST(1), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1) 17658030 31 28 31 12 2 3 5 15 6 0 0.842 1.000 1.000 579 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(4), CPS1(6), EPRS(2), GAD2(1), GFPT1(1), GLS(4), GLS2(2), GOT1(3), GOT2(2), GPT(1), GPT2(1), GSS(1) 20557233 30 27 30 10 1 4 5 14 6 0 0.729 1.000 1.000 580 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDS2(1), CHKB(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG2(1), PPAP2B(1), PPAP2C(2) 30852637 29 27 29 12 5 6 3 11 4 0 0.745 1.000 1.000 581 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CFL1(1), E2F1(1), PRB1(7), TP53(10) 5102483 30 27 29 10 3 3 5 11 8 0 0.606 1.000 1.000 582 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(3), ITGB1(3), ITGB3(1), PTK2(1), RAC1(1), SPTAN1(5), SRC(2), TLN1(4) 17808646 27 27 27 11 3 4 1 12 7 0 0.932 1.000 1.000 583 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(7), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1) 14356401 29 26 27 14 3 3 4 13 6 0 0.951 1.000 1.000 584 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(3), ADCY9(3), ARF1(1), ARF3(1), ARF6(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ERO1L(1), GNAS(4), PLCG2(1), SEC61B(1), TRIM23(2) 22897173 27 26 27 15 1 3 4 14 5 0 0.993 1.000 1.000 585 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), ARF1(1), BTK(1), EEA1(5), GSK3A(2), PFKL(1), PFKM(2), PRKCE(4), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(4) 15614399 28 26 27 10 1 5 3 12 7 0 0.807 1.000 1.000 586 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMPPB(1), HK1(4), KHK(4), MPI(1), PFKFB3(1), PFKM(2), PMM1(1), SORD(2), TPI1(1) 14906325 26 25 26 12 3 2 4 9 8 0 0.917 1.000 1.000 587 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(4), PFKM(2) 19923975 27 25 26 11 2 2 4 12 7 0 0.886 1.000 1.000 588 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A3(3) 16050674 26 25 26 10 3 10 2 8 3 0 0.632 1.000 1.000 589 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), IL22RA1(1), JAK1(4), JAK2(5), JAK3(4), STAT1(4), STAT3(1), STAT5B(1), TYK2(3) 11362682 24 24 24 12 1 0 4 14 5 0 0.980 1.000 1.000 590 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(4), POLR2A(6), RARA(4), TBP(1) 15541685 27 24 27 16 1 4 6 10 6 0 0.961 1.000 1.000 591 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGT(1), AGTR1(1), ANPEP(6), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(3), REN(1) 13008111 25 23 24 10 1 2 8 12 2 0 0.874 1.000 1.000 592 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), IDH1(2), MGST3(2) 11232717 23 22 22 10 2 0 6 10 5 0 0.956 1.000 1.000 593 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), REN(1) 16040168 23 21 23 10 3 9 1 6 4 0 0.786 1.000 1.000 594 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(4), CTNNB1(1), PTK2(1), SRC(2), VCL(2) 11855282 22 21 22 12 4 4 1 10 3 0 0.966 1.000 1.000 595 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), PLA2G4A(1), PLCB1(1), PTGS1(1), PTK2(1), SRC(2), SYK(1), TBXAS1(1) 15086673 22 21 22 13 2 3 3 7 7 0 0.979 1.000 1.000 596 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(6), ASAH1(1), EPHB2(1), ITPKA(1), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 17169842 21 21 21 10 4 2 3 10 2 0 0.867 1.000 1.000 597 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), PTGS1(1), PTGS2(4), TBXAS1(1) 12538726 20 20 20 12 1 3 3 8 5 0 0.971 1.000 1.000 598 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), CASP1(1), CASP7(1), INSR(3), MAGI1(2), MAGI2(4), RERE(3), WWP2(2) 14624161 18 18 17 13 3 2 2 7 4 0 0.998 1.000 1.000 599 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(2), PLCB1(1), PTK2(1), ROCK2(3) 15794685 19 17 19 11 1 2 0 12 4 0 0.993 1.000 1.000 600 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(1), GALNT2(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4) 9070518 17 17 17 11 0 1 6 6 4 0 0.993 1.000 1.000 601 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PPAP2B(1), PPAP2C(2) 14415375 17 16 17 9 1 2 4 10 0 0 0.912 1.000 1.000 602 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), SP3(1), SYT1(1) 12257733 15 15 15 11 2 3 2 5 3 0 0.992 1.000 1.000 603 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CCR5(3), CXCR4(1), JUN(2), MAPK14(1), PTK2B(2), SYT1(1) 8428473 12 10 11 7 1 3 1 7 0 0 0.930 1.000 1.000 604 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG2(2), NRG3(2) 5666673 10 10 10 5 1 3 0 6 0 0 0.850 1.000 1.000 605 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2) 6430723 9 9 9 5 2 1 2 4 0 0 0.805 1.000 1.000 606 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BID(1), BIRC2(3), BIRC3(2), CASP7(1) 8384011 7 7 7 4 0 2 1 4 0 0 0.862 1.000 1.000 607 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHA(1), SDHB(1), SDHD(1) 4061439 5 5 5 3 2 0 1 2 0 0 0.875 1.000 1.000 608 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(1), NR1H4(1) 3221997 3 3 3 3 0 1 0 2 0 0 0.974 1.000 1.000 609 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PTK2B(2) 4134066 3 3 3 6 0 2 0 1 0 0 0.997 1.000 1.000 610 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), SNCAIP(1), UBE2E2(1) 3943564 3 3 3 3 0 2 1 0 0 0 0.906 1.000 1.000 611 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(1), SP3(1) 4177849 2 2 2 2 0 2 0 0 0 0 0.962 1.000 1.000 612 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), PPARG(1) 3394881 2 2 2 2 1 1 0 0 0 0 0.902 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 993669 1 1 1 2 0 0 1 0 0 0 0.982 1.000 1.000 614 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 1301999 1 1 1 2 0 0 0 1 0 0 0.989 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 316078 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 3004629 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000