Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.013 0.056 -9999.0 0.0 -0.299 11.0 11.0 epithelial cell differentiation 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 CYFIP2 0.013 0.081 -9999.0 0.0 -0.639 7.0 7.0 ENAH 0.062 0.099 0.395 14.0 -9999.0 0.0 14.0 EGFR 0.018 0.07 -9999.0 0.0 -0.597 6.0 6.0 EPHA2 0.027 0.031 -9999.0 0.0 -0.639 1.0 1.0 MYO6 0.056 0.108 0.391 10.0 -0.49 2.0 12.0 CTNNB1 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.037 0.06 -9999.0 0.0 -0.405 7.0 7.0 AQP5 -0.108 0.239 -9999.0 0.0 -0.509 99.0 99.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.059 0.103 0.414 9.0 -9999.0 0.0 9.0 regulation of calcium-dependent cell-cell adhesion 0.051 0.114 0.412 9.0 -0.462 1.0 10.0 EGF -0.572 0.198 -9999.0 0.0 -0.635 428.0 428.0 NCKAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.008 0.154 -9999.0 0.0 -0.536 26.0 26.0 cortical microtubule organization 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 GO:0000145 0.05 0.102 0.406 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.071 -9999.0 0.0 -0.347 11.0 11.0 MLLT4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.007 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.065 0.037 -9999.0 0.0 -0.37 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.042 0.08 0.375 1.0 -9999.0 0.0 1.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.047 0.09 0.357 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.069 0.04 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.007 0.118 -9999.0 0.0 -0.62 16.0 16.0 EGFR/EGFR/EGF/EGF -0.246 0.143 -9999.0 0.0 -0.589 17.0 17.0 RhoA/GDP 0.029 0.066 -9999.0 0.0 -0.327 9.0 9.0 actin cytoskeleton organization 0.049 0.1 0.348 9.0 -0.459 2.0 11.0 IGF-1R heterotetramer 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.021 0.069 -9999.0 0.0 -0.589 6.0 6.0 DIAPH1 0.031 0.112 -9999.0 0.0 -0.671 7.0 7.0 Wnt receptor signaling pathway -0.028 0.069 0.343 11.0 -9999.0 0.0 11.0 RHOA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.008 0.044 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.05 0.101 0.35 9.0 -0.471 2.0 11.0 EFNA1 0.027 0.029 -9999.0 0.0 -0.589 1.0 1.0 LPP 0.047 0.09 0.412 4.0 -9999.0 0.0 4.0 Ephrin A1/EPHA2 0.023 0.063 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.002 0.047 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.051 0.115 0.415 9.0 -0.471 1.0 10.0 HGF/MET 0.013 0.09 -9999.0 0.0 -0.596 3.0 3.0 HGF 0.003 0.12 -9999.0 0.0 -0.594 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.013 0.057 -9999.0 0.0 -0.301 11.0 11.0 actin cable formation 0.104 0.128 0.33 65.0 -9999.0 0.0 65.0 KIAA1543 0.048 0.103 0.352 8.0 -0.54 2.0 10.0 KIFC3 0.05 0.092 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.053 0.098 0.446 6.0 -9999.0 0.0 6.0 NCK1/GIT1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.028 0.069 -9999.0 0.0 -0.343 11.0 11.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.05 0.09 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.059 0.104 0.416 9.0 -9999.0 0.0 9.0 LIMA1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.074 0.108 0.408 17.0 -9999.0 0.0 17.0 adherens junction assembly 0.07 0.134 0.503 14.0 -0.72 2.0 16.0 IGF-1R heterotetramer/IGF1 0.021 0.071 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.041 -9999.0 0.0 -0.589 2.0 2.0 PLEKHA7 0.057 0.105 0.36 8.0 -0.568 2.0 10.0 mol:GTP 0.063 0.036 -9999.0 0.0 -0.368 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.082 0.124 0.379 42.0 -9999.0 0.0 42.0 cortical actin cytoskeleton stabilization 0.013 0.056 -9999.0 0.0 -0.299 11.0 11.0 regulation of cell-cell adhesion 0.049 0.1 0.348 9.0 -0.459 2.0 11.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.013 0.057 -9999.0 0.0 -0.301 11.0 11.0