rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GPX1(2)	2578270	19	13	18	4	5	4	1	5	4	0	0.247	0.000134	0.0827
2	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(5)	662761	5	5	5	0	3	1	0	0	1	0	0.247	0.000976	0.301
3	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(3), FADS2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	3315078	18	10	18	2	3	3	3	6	3	0	0.0780	0.00554	1.000
4	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	11	CSF1R(3), EGF(3), MET(6), PDGFRA(8), PRKCA(3), SH3GLB1(3), SH3KBP1(3)	5489512	29	13	29	7	9	4	4	6	5	1	0.172	0.0210	1.000
5	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(2), DCN(1), FMOD(1), KERA(2), LUM(2)	1186959	8	7	8	3	1	1	2	4	0	0	0.701	0.0251	1.000
6	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(1), AGPS(2), ENPP2(3), ENPP6(1), PAFAH1B1(4), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(5), PPAP2A(2), PPAP2C(1)	7574393	34	16	34	6	6	5	6	12	5	0	0.0657	0.0304	1.000
7	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CDK2(1), CDKN1B(1), CUL1(1), E2F1(1), RB1(4), SKP2(2), UBE2M(1)	2798648	11	8	11	1	1	1	4	1	4	0	0.172	0.0341	1.000
8	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CDC34(1), CDK2(1), CUL1(1), E2F1(1), RB1(4), SKP2(2)	2788860	11	8	11	1	1	1	4	1	4	0	0.191	0.0349	1.000
9	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	GAD1(2), GAD2(1), GGT1(4)	1879746	7	6	7	0	2	1	2	2	0	0	0.0979	0.0391	1.000
10	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	5	AKT1(1), PLCB1(2), PLCG1(6), PRKCA(3), VAV1(4)	2959480	16	11	15	3	4	3	2	5	1	1	0.241	0.0471	1.000
11	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	ATP6V0C(1), GGT1(4), SHMT1(1)	1356911	6	5	6	1	2	1	2	1	0	0	0.303	0.0606	1.000
12	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(2), NAT1(1), NAT2(2), XDH(7)	2605500	12	7	12	0	4	1	0	5	2	0	0.0359	0.0697	1.000
13	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ASL(2), CPS1(4), GLS(1), GLUD1(3), GOT1(2)	2551489	12	6	12	2	1	2	0	4	5	0	0.440	0.0856	1.000
14	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	20	CFL1(1), LIMK1(2), MAP3K1(2), MYL2(1), MYLK(3), NCF2(3), PAK1(2), PDGFRA(8), PLD1(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(4), VAV1(4), WASF1(1)	10183713	39	20	39	7	9	6	6	6	12	0	0.0323	0.0983	1.000
15	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), TYR(4)	3164578	10	7	10	1	2	1	1	4	2	0	0.236	0.102	1.000
16	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	19	CSNK2A1(2), ELK1(3), INSR(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SLC2A4(1), SOS1(1), SRF(2)	7101587	28	15	27	7	6	7	1	9	4	1	0.204	0.106	1.000
17	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), ME1(1), PC(1), PDHA1(2), SLC25A1(1)	3033268	8	7	8	0	1	2	0	3	2	0	0.0677	0.110	1.000
18	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNB1(1), IL12B(2), IL15(2), IL16(6), IL6(1), IL9(1)	3243523	13	8	13	3	1	0	3	5	4	0	0.565	0.153	1.000
19	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(2), PTGS1(2), PTGS2(2)	1749706	6	5	6	0	3	0	0	2	1	0	0.263	0.166	1.000
20	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CDC34(1), CDK2(1), CUL1(1), E2F1(1), FBXW7(1), RB1(4)	2694035	9	6	9	1	1	1	2	1	4	0	0.326	0.177	1.000
21	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	28	CD4(1), HLA-DRA(2), IFNB1(1), IL12B(2), IL15(2), IL6(1), PDGFA(1), TGFB2(2), TGFB3(1)	4292787	13	8	13	1	3	0	3	6	1	0	0.133	0.183	1.000
22	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1)	4754155	17	8	17	0	1	6	3	5	2	0	0.00418	0.189	1.000
23	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(2), ICAM1(2), ITGA4(2), ITGAL(1), ITGB1(2), ITGB2(1), SELE(4)	3961834	14	10	13	4	6	4	2	1	1	0	0.277	0.199	1.000
24	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(2), LPO(5), MPO(2), PRDX1(1), TPO(3), TYR(4)	3153376	17	9	17	4	7	5	0	4	1	0	0.124	0.214	1.000
25	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5)	2616913	13	8	13	3	7	2	1	1	2	0	0.194	0.215	1.000
26	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5)	2616913	13	8	13	3	7	2	1	1	2	0	0.194	0.215	1.000
27	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(1), HLA-DRA(2)	776185	4	3	4	1	1	0	0	3	0	0	0.634	0.221	1.000
28	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(1), GOT1(2), TAT(1), TYR(4)	1541543	8	5	8	3	3	0	1	4	0	0	0.754	0.221	1.000
29	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(4), CDC25A(1), CDK2(1), CDK4(1), CHEK1(3), MYT1(3), RB1(4), WEE1(1), YWHAH(1)	5478684	19	9	19	8	3	2	3	2	9	0	0.844	0.226	1.000
30	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACPP(1), ENPP1(1), ENPP3(2), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(1), TYR(4)	4908377	14	8	14	2	2	3	1	5	3	0	0.238	0.234	1.000
31	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	14	ARF1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CFL1(1), E2F1(1), MDM2(2), PRB1(3)	2472825	14	8	14	4	3	3	3	3	2	0	0.344	0.242	1.000
32	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(4), NRG2(1), PRKCA(3)	2942732	8	5	8	0	1	1	2	2	1	1	0.0999	0.243	1.000
33	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH5A1(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), OXCT1(1), PDHA1(2), PDHA2(4)	8443299	31	16	31	8	12	6	2	5	6	0	0.101	0.245	1.000
34	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2)	4338548	24	11	24	5	10	1	2	8	3	0	0.128	0.251	1.000
35	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), UGDH(1)	2790874	15	8	15	2	9	2	1	1	2	0	0.0570	0.253	1.000
36	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	15	CD28(1), CD3D(1), CTLA4(1), HLA-DRA(2), ITK(1), PTPN11(6)	2952450	12	9	11	4	3	1	1	7	0	0	0.628	0.254	1.000
37	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	CLOCK(2), CRY1(2), CSNK1E(1), PER1(4)	2785609	9	5	9	0	2	2	1	2	2	0	0.102	0.260	1.000
38	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(10), ACAT2(1), ACYP1(1), ADH5(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1)	12106195	40	21	39	6	12	10	4	9	5	0	0.0105	0.264	1.000
39	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ3(1), COQ5(1), COQ6(1), NDUFB11(1)	1311079	4	3	4	0	0	2	0	2	0	0	0.310	0.266	1.000
40	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(2), CHAT(3), PDHA1(2), PDHA2(4)	2274001	11	6	11	2	2	5	1	1	2	0	0.137	0.273	1.000
41	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	18	CSNK2A1(2), ELK1(3), IGF1R(3), IRS1(2), MAPK3(1), MAPK8(1), PTPN11(6), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2)	6875073	27	17	26	7	4	6	2	8	6	1	0.231	0.278	1.000
42	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	NR1H3(4), RXRA(1)	1779152	5	4	4	1	2	1	2	0	0	0	0.372	0.281	1.000
43	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(3), PRKACG(1), PRKAR1A(1), PRKCA(3)	3116976	10	7	10	2	2	0	1	4	2	1	0.621	0.283	1.000
44	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(1), GLUD1(3), GLUD2(1)	1486985	5	4	5	2	0	2	0	2	1	0	0.734	0.288	1.000
45	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CBS(3), CTH(1), GGT1(4), MARS(4), MARS2(1), SCLY(2)	4048815	15	7	15	1	3	5	3	4	0	0	0.0224	0.290	1.000
46	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	GALNT1(1), GALNT12(2), GALNT14(2), GALNT2(2), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GCNT4(2), OGT(6), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	10562317	35	14	35	8	10	9	1	12	3	0	0.158	0.297	1.000
47	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(1), FUT2(2), FUT5(2), FUT6(2)	1652917	7	4	7	3	3	1	1	1	1	0	0.780	0.299	1.000
48	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	4	EGF(3), ERBB3(2), NRG1(2)	2506617	7	5	7	1	5	0	0	1	1	0	0.412	0.300	1.000
49	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(1), CYP1A2(2), CYP2C19(5), CYP2C8(1), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2)	7812605	24	17	24	5	8	4	3	4	5	0	0.186	0.310	1.000
50	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	TGDS(1), UGDH(1), UXS1(2)	1251006	4	3	4	1	0	1	2	0	1	0	0.624	0.317	1.000
51	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(2), TAT(1)	862363	3	2	3	1	1	0	1	1	0	0	0.729	0.318	1.000
52	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(4), SP3(2)	2175476	6	4	6	0	1	0	1	1	3	0	0.248	0.324	1.000
53	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(10), ACACB(5), ACAT2(1), ACSS1(1), ACSS2(3), ACYP1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), LDHB(1), ME1(1), ME3(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PKLR(1)	15324012	49	25	48	9	17	11	5	10	6	0	0.0136	0.333	1.000
54	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(1), ENO1(2), GPI(2), HK1(3), PFKL(2), PGAM1(1), PKLR(1), TPI1(1)	3032813	13	6	13	0	5	5	0	1	2	0	0.00331	0.339	1.000
55	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GGT1(4), SHMT1(1)	1795701	5	5	5	2	1	1	2	1	0	0	0.629	0.344	1.000
56	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), IDI1(1), SQLE(1)	1028226	3	2	3	0	0	0	3	0	0	0	0.337	0.347	1.000
57	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	20	AKT1(1), CCND1(1), CDK2(1), CDK4(1), CDKN1B(1), E2F1(1), MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(2), RAC1(1), RAF1(1), RB1(4), RELA(1)	5370583	19	8	19	6	4	0	3	1	10	1	0.477	0.351	1.000
58	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	20	CSNK2A1(2), JAK2(3), MAPK3(1), MPL(2), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), STAT1(2), STAT3(1), STAT5B(2)	8560869	29	15	28	4	6	3	2	9	6	3	0.0753	0.366	1.000
59	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(2), PLCD1(1), PRKCA(3)	1617433	6	3	6	1	2	0	1	2	0	1	0.394	0.368	1.000
60	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	10	AKT1(1), PLCG1(6), PRKCA(3), SHC1(1), SOS1(1)	3853702	12	8	11	2	3	2	2	2	2	1	0.261	0.373	1.000
61	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	GSTZ1(2), HGD(3)	728482	5	2	5	1	2	0	0	1	2	0	0.563	0.380	1.000
62	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CEBPB(1), CSNK2A1(2), ELK1(3), IL6(1), IL6ST(2), JAK2(3), JAK3(1), MAPK3(1), PTPN11(6), RAF1(1), SHC1(1), SOS1(1), SRF(2), STAT3(1)	7804745	26	15	25	7	3	6	1	11	4	1	0.317	0.383	1.000
63	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(1), B3GALT2(1), B3GALT5(1), B3GNT5(4), FUT2(2), ST3GAL4(1)	2349093	10	5	10	3	4	0	2	2	2	0	0.527	0.384	1.000
64	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(2), NFKB1(1), NOX1(1), RELA(1), XDH(7)	3245706	12	5	11	4	2	2	0	5	3	0	0.673	0.386	1.000
65	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	MAX(4), SP3(2), WT1(1)	2038473	7	4	6	0	3	1	0	3	0	0	0.0991	0.398	1.000
66	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ADCY4(4), CACNA1A(1), CACNA1B(7), GNAS(3), GRM4(2), ITPR3(6), KCNB1(2), PDE1A(1), PLCB2(1), PRKACG(1), SCNN1B(2), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(2), TAS2R13(1), TAS2R16(2), TAS2R3(1), TAS2R4(1), TAS2R40(1), TAS2R41(2), TAS2R42(1), TAS2R46(1), TAS2R5(1), TAS2R9(4), TRPM5(2)	18541990	55	29	55	9	19	9	3	15	9	0	0.0129	0.405	1.000
67	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(3)	691028	3	2	3	0	1	1	0	1	0	0	0.365	0.409	1.000
68	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), OXCT1(1)	1107888	2	2	2	0	0	1	0	1	0	0	0.592	0.420	1.000
69	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCL5(1), HLA-DRA(2)	996435	4	2	4	1	0	0	0	3	1	0	0.674	0.421	1.000
70	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	9	ACLY(3), ACO1(2), ACO2(2), ACSS1(1), ACSS2(3), FH(1)	3816120	12	6	12	0	5	2	0	2	3	0	0.0115	0.428	1.000
71	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(10), CPT1A(1), LEPR(1), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1)	4738591	19	7	18	2	4	2	1	9	3	0	0.0921	0.430	1.000
72	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	12	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), PAK1(2), PDGFRA(8), RAC1(1), WASL(1)	3152231	16	9	16	5	0	4	1	5	6	0	0.644	0.434	1.000
73	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), ABAT(1), ACADS(1), ACAT2(1), ACSM1(3), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH5A1(1), ALDH7A1(2), BDH1(1), BDH2(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), ILVBL(3), OXCT1(1), PDHA1(2), PDHA2(4), PLA1A(2)	13262829	49	21	49	11	18	8	3	11	9	0	0.0457	0.437	1.000
74	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(2), ICAM1(2), ITGAL(1), ITGAM(1), ITGB2(1), SELE(4)	3395059	11	8	10	4	5	4	1	0	1	0	0.384	0.442	1.000
75	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	TGDS(1), UGDH(1), UGP2(1), UXS1(2)	1595600	5	3	5	1	0	1	2	1	1	0	0.552	0.447	1.000
76	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(1), HTR2C(1), PLCB1(2), TUB(2)	2338960	6	4	6	2	2	1	0	2	1	0	0.574	0.451	1.000
77	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	CREB1(1), DAXX(2), DDIT3(1), ELK1(3), MAP3K1(2), MAP3K5(2), MAP3K9(3), MAPKAPK2(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), PLA2G4A(4), RAC1(1), RIPK1(1), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1)	11960444	38	20	37	8	9	5	7	11	5	1	0.152	0.454	1.000
78	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	23	CSNK2A1(2), EGF(3), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1)	10157802	33	16	32	7	9	6	2	8	5	3	0.148	0.458	1.000
79	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(2), ICAM1(2), ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(1), SELE(4), SELP(2)	5216686	17	11	16	6	6	4	3	3	1	0	0.450	0.466	1.000
80	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPP(2), GGH(1), SPR(1)	2123077	4	4	4	1	2	1	0	0	1	0	0.583	0.468	1.000
81	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	11	AKT1(1), CAT(2), GH1(1), GHR(2), IGF1R(3), SHC1(1), SOD2(1)	3117933	11	5	11	0	1	2	2	3	3	0	0.0199	0.472	1.000
82	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), IDI1(1), SQLE(1)	1381539	3	2	3	0	0	0	3	0	0	0	0.329	0.486	1.000
83	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(1), ATM(4), BAX(1), CCND1(1), CDK2(1), CDK4(1), E2F1(1), MDM2(2), RB1(4), TIMP3(1)	5643287	17	7	17	3	3	2	4	4	4	0	0.206	0.489	1.000
84	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(2), DHRS3(1), DHRS7(1), PON1(3)	2937587	9	5	8	2	5	0	0	1	3	0	0.457	0.490	1.000
85	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), F2(2), F5(7), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), PROS1(1), SERPING1(1)	14533608	49	24	49	11	13	11	9	8	7	1	0.0398	0.501	1.000
86	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(4), CDC25A(1), CHEK1(3), MYT1(3), WEE1(1), YWHAH(1)	4500786	13	6	13	8	2	2	1	2	6	0	0.954	0.502	1.000
87	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CYP2C19(5), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	10094223	34	15	33	8	19	4	2	3	6	0	0.0958	0.502	1.000
88	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(2), ANKRD1(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(1)	3502978	8	6	8	2	2	1	2	1	2	0	0.466	0.512	1.000
89	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(8), DAXX(2), PAX3(1), PML(3), RB1(4), SP100(3), TNFRSF1B(2)	5931762	23	9	23	4	5	2	2	7	7	0	0.194	0.521	1.000
90	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2)	1847236	9	4	9	3	1	0	1	6	1	0	0.662	0.524	1.000
91	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	23	GH1(1), GHR(2), INSR(3), IRS1(2), JAK2(3), MAPK1(1), MAPK3(1), PLCG1(6), PRKCA(3), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(1), SRF(2), STAT5B(2)	9574139	32	15	31	6	5	7	3	9	6	2	0.0694	0.525	1.000
92	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK2(3), JAK3(1), MAPK1(1), MAPK3(1), STAT3(1), TYK2(5)	3843701	12	5	12	3	3	0	0	5	3	1	0.506	0.532	1.000
93	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(1), PGLYRP2(1)	595423	2	2	2	0	2	0	0	0	0	0	0.524	0.534	1.000
94	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), JAK2(3), TYK2(5)	3432229	9	5	9	2	3	0	1	3	2	0	0.486	0.537	1.000
95	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), JAK2(3), TYK2(5)	3432229	9	5	9	2	3	0	1	3	2	0	0.486	0.537	1.000
96	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(1), ACADM(1), ACADS(1), ECHS1(2)	1766010	5	3	5	3	1	1	0	1	2	0	0.805	0.544	1.000
97	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), ABAT(1), ADSL(3), ADSSL1(1), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), ASS1(1), CAD(4), CRAT(1), DARS2(2), GAD1(2), GAD2(1), GOT1(2), NARS2(1), PC(1), PDHA1(2), PDHA2(4)	12369170	35	16	35	5	10	9	2	8	6	0	0.0159	0.544	1.000
98	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	APEX1(1), CREBBP(8), DFFA(1), PRF1(1), SET(1)	3452571	12	5	12	3	4	1	1	3	3	0	0.432	0.547	1.000
99	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(2), AGTR2(1), KNG1(1), NOS3(5), REN(1)	3242588	12	7	12	4	6	1	1	2	2	0	0.581	0.549	1.000
100	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG5(3), ATG7(3), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), PIK3C3(2), PIK3R4(2), PRKAA1(3), PRKAA2(2), ULK2(5)	6891181	25	8	25	2	5	2	5	8	5	0	0.0156	0.551	1.000
101	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(2)	1564496	4	4	4	2	2	0	0	1	1	0	0.865	0.553	1.000
102	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	373921	1	1	1	1	0	1	0	0	0	0	0.899	0.553	1.000
103	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	IL1B(1), MST1(5), MST1R(1)	2146039	7	3	7	2	2	3	0	2	0	0	0.397	0.559	1.000
104	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(1), CFTR(2), GNAS(3), PRKACG(1), PRKAR1A(1), SLC9A3R1(1)	4251851	10	9	10	3	3	1	1	2	3	0	0.609	0.560	1.000
105	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(3), ENPP1(1), ENPP3(2), NADSYN1(3), NMNAT3(1), NNMT(1), NNT(3), NT5C(2), NT5E(1), NT5M(1)	7028279	18	8	18	1	1	7	3	5	2	0	0.0161	0.563	1.000
106	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1)	1269548	2	2	2	0	0	0	0	1	1	0	0.516	0.573	1.000
107	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(3), PDXK(1)	1588407	4	2	4	2	0	2	0	2	0	0	0.818	0.573	1.000
108	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	SRP68(2), SRP72(3), SRPR(3)	2468694	8	3	8	0	3	0	1	2	2	0	0.151	0.575	1.000
109	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(3), FDFT1(1), HMGCS1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1)	4305225	12	5	12	4	5	1	3	3	0	0	0.465	0.579	1.000
110	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(10), ACADL(1), ACADM(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ECHS1(2), EHHADH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1)	10829006	40	15	39	10	12	11	2	10	5	0	0.139	0.581	1.000
111	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(2), ELK1(3), EPOR(1), JAK2(3), MAPK3(1), MAPK8(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1), STAT5B(2)	7019078	22	11	21	5	3	6	1	7	4	1	0.197	0.584	1.000
112	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	IL6(1), LPL(2)	1744905	3	3	3	0	0	0	0	3	0	0	0.585	0.590	1.000
113	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR2(1), JAK2(3), STAT1(2)	2674496	6	3	6	3	1	0	0	2	2	1	0.884	0.591	1.000
114	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA3(2), LTB4R(1), P2RY1(1), P2RY2(3), P2RY6(2)	1951749	9	3	9	4	5	2	0	2	0	0	0.573	0.591	1.000
115	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(2), F5(7), F7(2), FGA(4), FGB(1), PROS1(1)	5360112	17	12	17	5	6	1	4	4	2	0	0.382	0.594	1.000
116	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), PANK2(1), PANK4(2)	4546385	11	6	11	3	2	1	0	5	3	0	0.728	0.595	1.000
117	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CSNK1D(1), GRM1(4), PLCB1(2), PPP3CA(1), PRKACG(1), PRKAR1A(1)	5243365	10	7	10	3	0	1	0	6	3	0	0.877	0.595	1.000
118	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CHEK1(3), WEE1(1)	2242080	5	3	5	3	1	1	1	0	2	0	0.951	0.596	1.000
119	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	20	ADCY1(1), AKT1(1), BAX(1), CSF2RB(1), IGF1R(3), IL3RA(2), KIT(3), KITLG(2), PRKACG(1), PRKAR1A(1), YWHAH(1)	5938098	17	9	17	4	2	1	2	5	7	0	0.344	0.598	1.000
120	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCND1(1), CCNE2(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), PRB1(3)	2913685	12	7	12	3	3	2	4	2	1	0	0.289	0.599	1.000
121	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(10), ACACB(5), ACADM(1), ACAT2(1), ACSS1(1), ACSS2(3), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ALDH7A1(2), ECHS1(2), EHHADH(1), HIBCH(1), LDHB(1), MLYCD(3), MUT(1), PCCB(2), SUCLG2(1)	12987039	50	19	49	13	17	12	4	11	6	0	0.101	0.607	1.000
122	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(3), IFNGR2(1), JAK2(3), NFKB1(1), NFKBIA(1), RB1(4), RELA(1), TNFRSF1B(2), WT1(1)	5655273	17	7	17	8	4	1	1	4	7	0	0.829	0.612	1.000
123	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	COASY(1), DPYD(3), DPYS(1), ENPP1(1), ENPP3(2), ILVBL(3), PANK2(1), PANK4(2), VNN1(1)	5642594	15	8	15	3	3	2	0	6	4	0	0.452	0.613	1.000
124	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREB1(1), CREBBP(8), EP300(3), NCOA3(1), PRKACG(1), PRKAR1A(1), RXRA(1)	6758725	16	8	16	4	3	2	0	6	5	0	0.513	0.617	1.000
125	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	GUSB(2), UCHL3(1), UGDH(1), UGT1A1(6), UGT2B15(1), UGT2B4(2)	5753383	13	8	13	4	2	1	4	6	0	0	0.500	0.622	1.000
126	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCND1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), E2F1(1), RB1(4), RBL1(2)	5242883	18	8	18	4	4	2	5	3	4	0	0.278	0.623	1.000
127	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IL12B(2)	977103	3	2	3	2	0	1	1	1	0	0	0.846	0.629	1.000
128	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(1), LPL(2), NR3C1(2), PPARG(1), RXRA(1)	1899443	7	6	7	4	1	1	1	4	0	0	0.814	0.632	1.000
129	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKACG(1), PRKAR1A(1), PTPRC(4), ZAP70(3)	7485787	26	13	26	6	7	4	0	10	5	0	0.322	0.632	1.000
130	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3D(1), CD4(1), CREBBP(8), CSK(1), GNAS(3), HLA-DRA(2), PRKACG(1), PRKAR1A(1), PTPRC(4), ZAP70(3)	7485787	26	13	26	6	7	4	0	10	5	0	0.322	0.632	1.000
131	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	MARCKS(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), SP3(2)	6843413	24	11	23	6	9	3	3	5	3	1	0.234	0.636	1.000
132	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACPP(1), ALPP(2), CYP3A7(1), DHRS2(2), DHRS3(1), DHRS7(1), PON1(3)	5877262	11	8	10	1	6	0	0	1	4	0	0.0989	0.638	1.000
133	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(2), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EARS2(2), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GFPT2(3), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), GNPNAT1(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1)	12904560	41	18	41	10	8	9	4	12	8	0	0.159	0.639	1.000
134	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	49	AGT(2), AKT1(1), CALR(2), CAMK1G(1), CAMK4(2), CREBBP(8), CSNK1A1(2), F2(2), MAPK1(1), MAPK3(1), MAPK8(1), MYH2(9), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), RAF1(1), RPS6KB1(1)	15348511	48	20	48	12	17	6	2	13	9	1	0.0805	0.641	1.000
135	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(1), CFLAR(1), DAXX(2), DFFA(1), FAF1(3), LMNA(2), LMNB2(2), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(9), PTPN13(1), RB1(4), SPTAN1(2)	13226423	34	15	34	6	6	6	4	9	8	1	0.116	0.643	1.000
136	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	CD3D(1), HLA-A(1), ICAM1(2), ITGAL(1), ITGB2(1), PRF1(1)	2863254	7	5	7	3	3	2	1	0	1	0	0.526	0.644	1.000
137	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(2), ECHS1(2), EHHADH(1)	1580429	5	2	5	4	2	0	1	0	2	0	0.868	0.648	1.000
138	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(4), CPS1(4), EPRS(2), GAD1(2), GAD2(1), GCLC(1), GFPT1(1), GLS(1), GLUD1(3), GLUL(1), GOT1(2), NADSYN1(3), PPAT(2), QARS(1)	10840000	32	13	32	7	8	6	3	9	6	0	0.144	0.653	1.000
139	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CD3D(1), CD4(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), STAT4(2), TYK2(5)	4809186	16	6	16	5	6	2	1	5	2	0	0.484	0.656	1.000
140	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(4), CR2(3), HLA-DRA(2), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4)	4970171	17	11	17	5	6	4	0	4	3	0	0.320	0.657	1.000
141	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(4), CDKN2A(2), E2F1(1), MDM2(2), POLR1A(4), POLR1B(2), RAC1(1), RB1(4), TBX2(1)	5117948	21	8	21	6	5	1	3	5	7	0	0.403	0.660	1.000
142	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), CFL1(1), FLNA(8), FLNC(7), FSCN1(2), FSCN2(1), FSCN3(1), GDI1(3), LIMK1(2), MYH2(9), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), ROCK1(2), ROCK2(2), RPS4X(2), WASF1(1), WASL(1)	15637648	60	22	60	17	21	9	8	15	6	1	0.0982	0.667	1.000
143	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(1), GFPT1(1), GNE(1), GNPDA1(2), HEXA(1), HK1(3), HK2(2), HK3(1), RENBP(1)	5548225	14	7	14	4	3	4	3	3	1	0	0.389	0.670	1.000
144	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	6	EEA1(2), EGF(3), HGS(3), TF(1), TFRC(1)	3321756	10	6	10	2	4	2	1	2	1	0	0.303	0.674	1.000
145	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(1), GNAS(3), PLCE1(6), PRKACG(1), PRKAR1A(1), RAP2B(1)	4805367	14	9	14	4	4	3	1	2	4	0	0.501	0.675	1.000
146	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	GUSB(2), UGDH(1), UGP2(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	8935182	29	17	28	9	5	2	8	13	1	0	0.429	0.687	1.000
147	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(1)	2136972	3	3	3	0	0	1	0	2	0	0	0.357	0.688	1.000
148	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(1)	2136972	3	3	3	0	0	1	0	2	0	0	0.357	0.688	1.000
149	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(1), HLA-DRA(2), PTPRC(4), ZAP70(3)	2955188	12	6	12	2	4	3	0	5	0	0	0.232	0.688	1.000
150	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	BCR(1), BLNK(2), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(4), RAC1(1), RPS6KA1(2), RPS6KA3(2), SHC1(1), SOS1(1), VAV1(4), VAV2(1), VAV3(5)	10477468	35	16	33	9	6	6	1	13	8	1	0.262	0.689	1.000
151	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(2), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), CCL5(1), CSK(1), F11R(1), GIT1(1), JAM2(3), JAM3(2), MAP3K14(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK8(1), MAPK9(1), MET(6), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(1), PAK1(2), PLCG1(6), PLCG2(7), PTPN11(6), PTPRZ1(7), RAC1(1), RELA(1), TCIRG1(1), TJP1(4)	22116980	74	32	72	18	22	12	9	15	15	1	0.0475	0.693	1.000
152	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CD28(1), CD3D(1), CD4(1)	1052589	3	2	3	2	1	1	0	1	0	0	0.811	0.697	1.000
153	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(3), AGXT(2), AGXT2(1), ASL(2), ASNS(2), ASPA(1), CAD(4), CRAT(1), GAD1(2), GAD2(1), GOT1(2), PC(1)	8520098	24	10	24	2	7	6	0	7	4	0	0.0115	0.697	1.000
154	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), PARK2(1), SNCA(1), SNCAIP(1)	2106098	4	3	4	2	3	0	0	1	0	0	0.719	0.703	1.000
155	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), SEC22B(1), SNAP29(1), STX11(1), TSNARE1(4), USE1(1), VAMP3(1), VAMP4(1), VAMP8(1), VTI1A(1)	5457423	14	8	14	7	3	3	1	1	6	0	0.836	0.707	1.000
156	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(1), CHRNA1(2)	1064742	3	3	3	2	1	0	0	1	1	0	0.802	0.707	1.000
157	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(2), GLS(1), GLUD1(3), OAT(1)	1800853	7	4	7	3	1	1	0	3	2	0	0.766	0.709	1.000
158	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(2), LPO(5), MPO(2), MTHFR(6), SHMT1(1), TPO(3)	3794168	22	8	22	5	8	7	1	4	2	0	0.0713	0.711	1.000
159	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	FOSB(1), GRIA2(2)	1226956	3	2	3	0	1	0	0	2	0	0	0.423	0.716	1.000
160	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	16	CSNK2A1(2), ELK1(3), MAPK3(1), MAPK8(1), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(1)	5005685	17	9	16	5	2	6	1	4	3	1	0.348	0.717	1.000
161	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	7	ACO1(2), ACO2(2), FH(1)	2377693	5	3	5	0	3	1	0	0	1	0	0.163	0.723	1.000
162	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), ATP6V0C(1), CAT(2), EPX(2), LPO(5), MPO(2), PRDX1(1), SHMT1(1), TPO(3)	3858611	18	7	18	5	7	7	0	2	2	0	0.117	0.725	1.000
163	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	JAK2(3), JAK3(1), STAT1(2), STAT3(1), STAT5B(2), TYK2(5)	6016194	14	6	14	4	3	0	0	8	2	1	0.657	0.728	1.000
164	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB27A(1), RAB3A(1), RAB9A(1)	1382777	3	2	3	0	2	1	0	0	0	0	0.267	0.730	1.000
165	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(1), UBE2D3(2), UBE2M(1)	3440753	4	4	3	7	0	0	1	0	3	0	1.000	0.734	1.000
166	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1)	1276996	1	1	1	1	0	1	0	0	0	0	0.876	0.737	1.000
167	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), CRADD(1), DFFA(1), LMNA(2), LMNB2(2), MADD(1), MAP3K1(2), MAPK8(1), PAK1(2), PRKDC(9), RB1(4), RIPK1(1), SPTAN1(2), TRADD(1)	12602660	30	17	30	6	8	4	4	5	8	1	0.162	0.740	1.000
168	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(2), AGPAT3(1), AGPS(2), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GNPAT(1), LGALS13(2), PAFAH1B1(4), PAFAH2(2), PCYT1B(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(1), PLCG1(6), PLCG2(7), PPAP2A(2), PPAP2C(1)	16311727	59	29	58	15	21	11	6	12	9	0	0.0890	0.740	1.000
169	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1)	15987288	55	23	55	11	20	12	5	12	6	0	0.00961	0.741	1.000
170	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PGAM1(1), PKLR(1), TPI1(1)	15987288	55	23	55	11	20	12	5	12	6	0	0.00961	0.741	1.000
171	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(1), ESR2(3), PDE1A(1), PDE1B(2), PLCB1(2), PLCB2(1)	3634847	10	8	10	4	3	3	0	2	2	0	0.630	0.745	1.000
172	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	40	CD3D(1), ELK1(3), FYN(1), LAT(1), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), PTPN7(1), RAC1(1), RAF1(1), RASA1(4), RELA(1), SHC1(1), SOS1(1), VAV1(4), ZAP70(3)	14396987	50	20	49	13	19	7	3	11	8	2	0.111	0.746	1.000
173	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	13	AKT1(1), IGF1R(3), POLR2A(3), PRKCA(3), RB1(4), TEP1(7), TERF1(1), XRCC5(1)	8075717	23	10	23	3	7	1	5	4	5	1	0.0437	0.746	1.000
174	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(2), ALG6(3), CCKBR(3), CELSR1(8), CELSR2(9), CELSR3(9), CHRM3(2), EMR2(2), EMR3(1), FSHR(2), GHRHR(2), GNRHR(2), GPR116(5), GPR132(3), GPR133(2), GPR143(3), GPR61(2), GPR77(1), GPR84(2), GRM1(4), GRPR(2), HRH4(1), LPHN2(5), LPHN3(3), LTB4R2(1), NTSR1(1), OR8G2(1), P2RY13(1), PTGFR(5), SMO(2), SSTR2(1), TAAR5(1), TSHR(4)	21771288	95	35	95	29	31	20	11	22	11	0	0.0604	0.748	1.000
175	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(3), BAIAP2(2), CASP1(1), INSR(3), MAGI1(2), MAGI2(4), RERE(7), WWP1(3)	7834218	25	11	25	7	9	6	1	5	4	0	0.300	0.752	1.000
176	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(1), NFS1(3), THTPA(2)	2097971	9	2	9	2	1	3	0	4	1	0	0.514	0.754	1.000
177	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(1), ARSD(2), ARSE(2), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SMPD1(1), SMPD2(1), SPTLC1(2), SPTLC2(1), UGCG(2)	7906066	29	12	28	6	10	3	1	9	6	0	0.186	0.756	1.000
178	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), LPA(5), PLAT(1), PLAU(1), PLG(3), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(5)	11540807	47	17	47	11	13	6	6	13	9	0	0.0867	0.758	1.000
179	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(3), PRKAR1A(1)	2137362	5	5	5	2	1	0	0	2	2	0	0.796	0.765	1.000
180	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(1), HLA-DRA(2)	1300108	4	3	4	2	1	0	0	3	0	0	0.800	0.769	1.000
181	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(1), GCK(1), GOT1(2), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PC(1), PCK1(3), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TNFAIP1(2), TPI1(1)	13904346	42	17	42	3	15	14	3	7	3	0	4.55e-05	0.774	1.000
182	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	45	INPP4B(3), INPP5B(2), INPPL1(4), IPMK(1), ISYNA1(2), ITGB1BP3(1), ITPK1(2), MINPP1(1), OCRL(4), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), SYNJ1(4), SYNJ2(7)	23309715	83	35	82	19	22	17	8	24	12	0	0.0342	0.778	1.000
183	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT2(2), GALNT4(2), GALNT6(2), GALNT8(1), GALNT9(2), ST3GAL1(1), ST3GAL4(1), WBSCR17(4)	4727482	16	6	16	4	7	4	0	4	1	0	0.259	0.780	1.000
184	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(2), TPI1(1)	538884	3	1	3	0	0	3	0	0	0	0	0.291	0.781	1.000
185	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(2), CHAT(3), DDC(1), GAD1(2), GAD2(1), HDC(2), PAH(1), TH(1), TPH1(2)	4695216	16	7	16	6	7	5	0	2	2	0	0.417	0.785	1.000
186	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), IL3RA(2), JAK2(3), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2)	5777052	12	6	12	3	2	0	0	5	4	1	0.499	0.787	1.000
187	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(3), ABCB11(1), ABCB4(4), ABCC1(4), ABCC3(5)	4691159	17	6	17	4	4	2	3	5	2	1	0.290	0.787	1.000
188	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(3), AMY2B(2), ENPP1(1), ENPP3(2), G6PC(3), GAA(5), GANAB(2), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), MGAM(4), PYGB(1), PYGL(3), PYGM(1), SI(6), UCHL3(1), UGDH(1), UGT1A1(6), UGT2B15(1), UGT2B4(2), UXS1(2)	18613303	59	30	59	14	17	11	10	15	6	0	0.0553	0.787	1.000
189	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP1(1), RANBP2(4)	2758159	5	3	5	0	1	1	1	1	1	0	0.168	0.790	1.000
190	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(2), ECHS1(2), HSD17B4(2), MECR(1), PPT2(2)	2770585	9	5	9	5	2	1	0	2	4	0	0.874	0.791	1.000
191	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(1), HK1(3), HK2(2), HK3(1), ISYNA1(2), TGDS(1)	3818082	10	5	10	2	3	4	2	1	0	0	0.183	0.792	1.000
192	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	IARS(1), LARS(3), PDHA1(2), PDHA2(4)	3284254	10	5	10	3	1	2	2	2	3	0	0.538	0.793	1.000
193	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1)	2276418	8	3	8	4	0	0	1	4	3	0	0.908	0.793	1.000
194	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(1), CBR3(1), CYP4F3(4), EPX(2), GGT1(4), LPO(5), LTA4H(3), MPO(2), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGES2(1), PTGS1(2), PTGS2(2), TPO(3)	9125763	42	24	42	12	11	10	5	9	7	0	0.121	0.794	1.000
195	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(2), OXCT1(1)	2343265	7	2	7	0	1	3	0	3	0	0	0.119	0.798	1.000
196	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(6), PRKCA(3)	2203308	12	8	11	6	5	2	2	1	1	1	0.769	0.799	1.000
197	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(3), CBS(3), CTH(1), MUT(1)	1603537	8	2	8	0	2	5	0	1	0	0	0.0468	0.799	1.000
198	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(2), BLVRA(2), CP(3), EPRS(2), GUSB(2), HCCS(3), UGT1A1(6), UGT2B15(1), UGT2B4(2), UROS(1)	8961250	24	13	24	5	6	1	8	9	0	0	0.166	0.800	1.000
199	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	HLCS(3)	1007612	3	1	3	2	0	1	0	1	1	0	0.838	0.803	1.000
200	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2E1(3), GTF2F1(2), GTF2H1(1), GTF2IRD1(2), TAF1(6), TAF1L(1), TAF2(1), TAF4(2), TAF4B(3), TAF5L(2), TAF6(1), TAF6L(1), TAF7L(1), TAF9(2), TAF9B(1), TBPL1(1)	11771842	30	12	30	5	6	8	3	8	4	1	0.0554	0.804	1.000
201	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNAR2(2), IFNB1(1), STAT1(2), TYK2(5)	3540963	10	4	10	3	2	0	1	5	1	1	0.697	0.806	1.000
202	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NQO2(1), SQLE(1)	3607507	9	3	9	4	3	1	3	1	1	0	0.586	0.810	1.000
203	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	36	EEF1A2(1), EEF1B2(2), EEF1D(3), EEF2(1), EEF2K(1), EIF2AK3(2), EIF2B4(1), EIF4A1(3), EIF4A2(1), EIF4E(1), EIF4G1(3), EIF4G3(4), GSPT2(4), KIAA0664(4), PABPC1(4), PABPC3(2), PAIP1(1)	14223172	38	24	37	9	8	6	5	9	10	0	0.225	0.811	1.000
204	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(1), BAX(1), BCL2L11(1), CASP8AP2(2), CES1(1)	3516106	6	3	6	0	1	2	0	1	2	0	0.181	0.812	1.000
205	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(1)	1546128	1	1	1	0	0	0	0	0	1	0	0.719	0.818	1.000
206	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	24	CSNK2A1(2), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(8), PLCG1(6), PRKCA(3), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SRF(2), STAT1(2), STAT3(1)	10185839	39	21	38	11	8	9	3	8	8	3	0.316	0.819	1.000
207	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(9), C5(4), C6(2), C7(4), C8A(1)	4102799	20	10	20	8	5	2	3	5	5	0	0.600	0.826	1.000
208	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAD(2), ALAS1(1), CPO(1), HBA2(1), UROS(1)	2575668	6	2	6	1	3	0	0	2	1	0	0.393	0.832	1.000
209	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(8), EP300(3), ESR1(1), MAPK1(1), MAPK3(1), PELP1(1)	4819147	15	4	15	4	5	1	0	5	3	1	0.443	0.833	1.000
210	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), NFKBIA(1), PLCB1(2), PRKCA(3), RELA(1)	2691881	8	5	8	5	2	0	1	3	1	1	0.870	0.833	1.000
211	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), RAC1(1), WASF1(1), WASL(1)	2658707	7	2	7	1	0	1	1	4	1	0	0.365	0.835	1.000
212	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	13	AKT1(1), IGF1R(3), IRS1(2), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(1), YWHAH(1)	4970638	12	7	12	3	1	2	1	1	6	1	0.312	0.835	1.000
213	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ECHS1(2), EHHADH(1)	3977369	16	9	16	7	8	2	1	1	4	0	0.521	0.840	1.000
214	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	14	AKT1(1), CREB1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NFKB1(1), RB1(4), RELA(1)	5113699	15	6	15	6	6	1	1	1	5	1	0.701	0.840	1.000
215	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CD4(1), HLA-DRA(2), IL1B(1), IL5RA(1), IL6(1)	1747785	7	3	7	2	0	0	0	7	0	0	0.710	0.841	1.000
216	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(1), HK1(3), HK2(2), HK3(1), TGDS(1)	3346466	8	4	8	2	3	3	2	0	0	0	0.296	0.842	1.000
217	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), NAGLU(2), SPAM1(1)	6699207	19	8	19	5	7	1	4	3	4	0	0.423	0.843	1.000
218	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(1), JAK2(3), PTPRU(2), REG1A(1), STAT1(2)	3734110	9	5	9	4	2	1	0	2	3	1	0.743	0.844	1.000
219	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	35	BTK(1), ELK1(3), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLA2G4A(4), PLCG1(6), PPP3CA(1), PPP3CC(1), RAF1(1), SHC1(1), SOS1(1), VAV1(4)	12840771	38	17	37	10	11	6	4	11	5	1	0.194	0.846	1.000
220	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(3), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(1)	4996404	13	7	13	4	3	0	0	6	4	0	0.746	0.848	1.000
221	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AGPAT3(1), AKR1A1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CEL(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK(1), GLA(1), GLB1(1), LCT(5), LIPC(1), LIPG(2), LPL(2), PNLIP(1), PNLIPRP1(3), PPAP2A(2), PPAP2C(1)	15748464	57	20	57	15	22	6	9	13	7	0	0.0719	0.848	1.000
222	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	GAD1(2), HDC(2), TH(1), TPH1(2)	1972646	7	3	7	2	4	2	0	1	0	0	0.349	0.849	1.000
223	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKACG(1), PRKAG1(1)	3297900	7	3	7	1	1	0	0	4	2	0	0.487	0.850	1.000
224	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(1), GCDH(1)	2549570	6	3	6	5	1	1	0	2	2	0	0.932	0.856	1.000
225	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT3(1), CHPF(1), CHST11(1), CHST13(1), CHST3(2), CHSY1(1), DSE(1), XYLT1(1), XYLT2(1)	4549569	10	6	10	2	3	1	0	6	0	0	0.349	0.857	1.000
226	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	RIPK1(1), TNFRSF1B(2), TRADD(1)	2735438	4	3	4	2	2	0	0	0	2	0	0.775	0.859	1.000
227	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AGK(1), AGPAT3(1), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CEL(1), DAK(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), GK(1), GK2(3), GLA(1), GLB1(1), GPAM(1), LCT(5), LIPA(2), LIPC(1), LIPG(2), LPL(2), MGLL(1), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(2), PPAP2C(1)	19181957	69	23	69	16	26	6	12	17	8	0	0.0279	0.860	1.000
228	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ARAF(1), ATF4(1), BRAF(3), CACNA1C(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CREBBP(8), EP300(3), GRIA1(4), GRIA2(2), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), GRM1(4), GRM5(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PPP1CB(1), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), RAF1(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2)	32509929	98	38	98	25	25	10	12	30	19	2	0.0725	0.861	1.000
229	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), LCT(5), MPI(1), PYGL(3), PYGM(1), TPI1(1), TREH(1)	4388226	15	6	15	4	4	4	2	1	4	0	0.273	0.862	1.000
230	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	16	AKT1(1), EIF4E(1), IGF1R(3), INPPL1(4), RPS6KB1(1)	4928933	10	4	10	3	1	2	2	2	3	0	0.420	0.866	1.000
231	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	31	AKT1(1), APC(2), AR(3), BRAF(3), DAG1(1), GNA11(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(1), PHKA2(4), PIK3CD(1), PITX2(3), PTX3(1), RAF1(1)	15367778	46	17	46	12	12	5	11	12	5	1	0.167	0.867	1.000
232	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), FHL5(1), FSHR(2), GNAS(3), XPO1(1)	3107805	8	7	8	3	1	1	1	3	2	0	0.771	0.869	1.000
233	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA2(2), ACAT2(1), ECHS1(2), EHHADH(1)	2732852	6	4	6	7	1	1	0	1	3	0	0.986	0.869	1.000
234	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(1), BTK(1), FYN(1), GAB2(1), INPP5D(2), KRAS(1), LAT(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(7), PRKCA(3), RAC1(1), RAC2(1), RAF1(1), SOS1(1), SOS2(4), VAV1(4), VAV2(1), VAV3(5)	22352957	76	35	73	20	24	13	10	15	12	2	0.0649	0.871	1.000
235	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(3), AGT(2), AGTR2(1), ANPEP(2), CMA1(2), CTSG(1), ENPEP(4), LNPEP(1), MME(2), REN(1), THOP1(3)	6931932	24	10	24	4	7	5	1	7	4	0	0.0724	0.871	1.000
236	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), GNAI1(1), GNAS(3), MAPK1(1), MAPK3(1), MYT1(3), PRKACG(1), PRKAR1A(1), RPS6KA1(2)	6691715	14	10	14	9	1	0	0	4	8	1	0.963	0.876	1.000
237	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(1), CHST13(1), SULT2A1(1), SULT2B1(2), SUOX(1)	2995273	7	3	7	3	0	1	0	5	1	0	0.814	0.877	1.000
238	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	GLB1(1), GUSB(2), HEXA(1), IDS(1), LCT(5), NAGLU(2)	4701953	12	5	12	4	6	1	2	1	2	0	0.555	0.879	1.000
239	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(3), ACYP1(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1A1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), ALDOB(1), ENO1(2), ENO2(1), ENO3(1), FBP1(1), FBP2(2), G6PC(3), G6PC2(1), GALM(1), GAPDHS(1), GCK(1), GPI(2), HK1(3), HK2(2), HK3(1), LDHB(1), PDHA1(2), PDHA2(4), PFKL(2), PGAM1(1), PGAM2(1), PKLR(1), TPI1(1)	19041582	67	26	67	10	25	12	6	16	8	0	0.000423	0.880	1.000
240	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(8), EP300(3), LPL(2), NCOA1(1), PPARG(1), RXRA(1)	6036117	16	8	16	5	3	3	0	8	2	0	0.592	0.880	1.000
241	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	EGR1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	2682816	6	2	6	3	1	2	0	0	2	1	0.521	0.883	1.000
242	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), MAPK1(1), MAPK8(1), PRKCA(3)	2888684	6	2	6	1	1	1	1	0	2	1	0.221	0.884	1.000
243	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	18	ACO1(2), ACO2(2), FH(1), IDH3B(1), PC(1), PCK1(3), SDHA(1), SUCLG2(1)	6201695	12	7	12	2	4	4	1	1	2	0	0.124	0.884	1.000
244	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	14	CD4(1), IL6(1), IL9(1)	1947293	3	2	3	1	0	0	0	2	1	0	0.803	0.884	1.000
245	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	19	AKT1(1), ELK1(3), H2AFX(1), MAPK3(1), NFKB1(1), RAC1(1), RAF1(1), RALA(1), RALBP1(1), RALGDS(3), RELA(1)	4988737	15	7	15	7	4	1	1	3	5	1	0.744	0.885	1.000
246	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD3D(1), CD4(1), IL6(1), KITLG(2)	2019579	5	2	5	1	0	1	1	3	0	0	0.522	0.887	1.000
247	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(5), MAP2(4), PRKACG(1), PRKAG1(1)	5944506	11	5	11	3	1	2	1	4	3	0	0.562	0.888	1.000
248	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(1), BAX(1), BIRC2(1), CYCS(2), DFFA(1), DIABLO(1)	4386978	7	3	7	1	1	2	0	3	1	0	0.323	0.892	1.000
249	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CSK(1), PRKCA(3), PTPRA(4)	3016988	9	2	9	3	3	2	2	1	0	1	0.500	0.893	1.000
250	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BFAR(1), BRAF(3), CREB1(1), MAPK1(1), RAF1(1), SNX13(1)	3647303	8	3	8	2	1	0	2	2	3	0	0.412	0.893	1.000
251	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNB1(1), PTPRU(2), REG1A(1), STAT1(2), TYK2(5)	4087799	11	6	11	4	2	1	1	3	3	1	0.705	0.894	1.000
252	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	ST3GAL1(1), ST3GAL4(1), ST6GALNAC4(1)	1852581	3	3	3	3	2	0	0	0	1	0	0.946	0.895	1.000
253	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(2), AXIN1(1), BTRC(1), CCND1(1), CREBBP(8), CSNK1A1(2), CSNK1D(1), CSNK2A1(2), CTBP1(3), FZD1(1), NLK(1), WIF1(2)	9590894	25	8	25	5	5	4	2	9	5	0	0.170	0.896	1.000
254	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	MMP9(1), RECK(2), TIMP3(1), TIMP4(1)	2462085	5	2	5	2	1	2	1	0	1	0	0.610	0.898	1.000
255	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(1), ARSD(2), ARSE(2), B4GALT6(1), DEGS1(2), DEGS2(1), GALC(3), GLA(1), GLB1(1), LCT(5), NEU1(1), NEU2(2), NEU3(1), PPAP2A(2), PPAP2C(1), SGMS2(2), SGPP1(1), SGPP2(1), SMPD1(1), SMPD2(1), SMPD3(2), SPTLC1(2), SPTLC2(1), UGCG(2)	11655704	39	14	38	8	13	4	2	14	6	0	0.103	0.900	1.000
256	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(2), BTK(1), ELK1(3), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1), VAV1(4)	12495234	39	15	38	10	13	6	3	9	6	2	0.135	0.900	1.000
257	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), ENO3(1), FARS2(2), GOT1(2), PAH(1), TAT(1), YARS(1)	2719843	11	4	11	3	5	2	1	1	2	0	0.446	0.900	1.000
258	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), MAPK3(1), POLR2A(3), PRKACG(1), PRKAR1A(1)	4210359	7	4	7	2	1	0	0	3	2	1	0.652	0.904	1.000
259	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	41	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGAP4(1), ARHGEF11(1), BTK(1), CFL1(1), GDI1(3), INPPL1(4), ITPR1(2), ITPR2(11), ITPR3(6), LIMK1(2), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDK1(2), PIK3CD(1), PIK3CG(4), PITX2(3), PPP1R13B(1), ROCK1(2), ROCK2(2), RPS4X(2), SAG(2), WASF1(1), WASL(1)	21412275	71	25	71	18	17	14	14	19	7	0	0.0756	0.904	1.000
260	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1)	5394351	15	10	15	5	4	2	2	4	3	0	0.666	0.905	1.000
261	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(1), BCR(1), BTK(1), CDKN2A(2), FLOT1(1), FLOT2(1), ITPR1(2), ITPR2(11), ITPR3(6), PDK1(2), PHF11(1), PITX2(3), PLCG2(7), PPP1R13B(1), PREX1(5), PTPRC(4), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SAG(2), TEC(1), VAV1(4)	17069951	63	25	63	17	21	11	8	20	3	0	0.119	0.906	1.000
262	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CYCS(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), NFKB1(1), NSMAF(1), RAF1(1), RELA(1), RIPK1(1), SMPD1(1), TRADD(1)	6707373	15	8	15	7	4	2	0	3	5	1	0.749	0.907	1.000
263	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(2), AGTR2(1), CMA1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), REN(1)	8257680	24	10	24	8	7	9	1	3	3	1	0.416	0.909	1.000
264	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(2), AASDHPPT(1)	2277318	3	2	3	0	0	0	1	1	1	0	0.384	0.910	1.000
265	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PFKL(2), PRPS1L1(1), PRPS2(3), RBKS(1), TALDO1(2), TKT(2), TKTL2(1)	7940739	23	11	23	7	11	7	0	2	3	0	0.151	0.911	1.000
266	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	12	AKT1(1), GH1(1), GHR(2), NFKB1(1), NFKBIA(1), RELA(1), YWHAH(1)	3361229	8	4	8	4	2	1	1	2	2	0	0.818	0.914	1.000
267	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(1), IL6(1), JAK2(3), JAK3(1), PIAS3(1), PTPRU(2), REG1A(1), STAT3(1)	4984696	11	8	11	4	2	1	0	5	3	0	0.658	0.914	1.000
268	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	20	AKT1(1), BCR(1), CRKL(1), JAK2(3), MAP3K1(2), MAPK3(1), MAPK8(1), RAF1(1), SOS1(1), STAT1(2), STAT5B(2)	7944728	16	6	16	4	4	3	0	4	3	2	0.296	0.915	1.000
269	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	FBP2(2), G6PC(3), GAA(5), GANAB(2), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4)	10655193	30	14	30	9	17	4	2	5	2	0	0.252	0.915	1.000
270	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), GOT1(2), PAH(1), TAT(1), YARS(1)	2847929	7	4	7	3	2	2	1	1	1	0	0.736	0.916	1.000
271	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(2), ECHS1(2), EHHADH(1), HSD17B4(2), SIRT7(1)	3873594	8	4	8	5	2	0	1	2	3	0	0.906	0.917	1.000
272	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(1), KDR(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NOS3(5), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(6), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCA(3), PRKCG(1), PTGS2(2), PTK2(1), RAC1(1), RAC2(1), RAF1(1), SH2D2A(1), SHC2(1), VEGFA(2)	22283289	85	37	84	24	31	11	15	14	12	2	0.0544	0.917	1.000
273	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B4GALNT1(2), GLB1(1), HEXA(1), LCT(5), SLC33A1(2), ST3GAL1(1), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3)	5392115	18	9	18	7	9	1	1	1	6	0	0.768	0.918	1.000
274	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TPI1(1)	5898973	12	5	12	2	5	2	1	2	2	0	0.213	0.922	1.000
275	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(1), SHH(1), XPO1(1)	2835325	5	3	5	3	1	4	0	0	0	0	0.752	0.923	1.000
276	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	IARS(1), IARS2(2), ILVBL(3), LARS(3), PDHA1(2), PDHA2(4), VARS(3), VARS2(1)	6079186	19	7	19	5	3	4	2	6	4	0	0.431	0.925	1.000
277	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	CLOCK(2), CRY1(2), CSNK1D(1), CSNK1E(1), NPAS2(1), NR1D1(1), PER1(4), PER2(3), PER3(1)	5577406	16	6	16	5	2	4	1	7	2	0	0.628	0.926	1.000
278	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(1), ARHGAP5(1), ARHGDIB(1), CASP1(1), CASP10(1), CYCS(2), PRF1(1)	4209081	8	4	8	4	1	4	0	3	0	0	0.750	0.928	1.000
279	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(2), ALG6(3), DAD1(1), DHDDS(1), DPAGT1(1), DPM1(2), FUT8(3), GANAB(2), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(2), RPN2(1), ST6GAL1(1), STT3B(1)	13833237	43	17	43	11	9	9	7	7	11	0	0.222	0.928	1.000
280	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	9	EGF(3), MAP3K1(2), NCOR2(3), RXRA(1)	4780778	9	6	9	4	4	2	0	2	1	0	0.692	0.929	1.000
281	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4928004	7	3	7	1	2	4	0	0	0	1	0.221	0.929	1.000
282	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4928004	7	3	7	1	2	4	0	0	0	1	0.221	0.929	1.000
283	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), SHMT1(1)	4928004	7	3	7	1	2	4	0	0	0	1	0.221	0.929	1.000
284	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	DNAJC3(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1)	2921183	6	2	6	4	1	2	0	1	2	0	0.864	0.929	1.000
285	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHA4(5), EPHB1(1), FYN(1), ITGA1(2), ITGB1(2), L1CAM(4), SELP(2)	5164763	17	5	17	5	5	3	2	6	1	0	0.373	0.930	1.000
286	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACAA2(2), ACADM(1), ACADS(1), ACAT2(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), ALDH7A1(2), AOX1(3), BCKDHA(1), DBT(2), ECHS1(2), EHHADH(1), HIBADH(1), HIBCH(1), HMGCS1(1), HMGCS2(2), HSD17B4(2), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2)	14064956	48	18	47	13	17	11	3	8	9	0	0.157	0.930	1.000
287	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	HSD11B1(1)	2262904	1	1	1	1	1	0	0	0	0	0	0.848	0.930	1.000
288	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(2), RPL10L(1), RPL13A(1), RPL18A(1), RPL29(1), RPL32(1), RPL37A(1), RPL6(1), RPL7(2), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPSA(2)	7355295	18	7	18	2	7	2	3	4	2	0	0.124	0.933	1.000
289	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(1), APC(2), DAG1(1), DLG4(3), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RYR1(9)	14959075	46	16	46	11	12	6	9	11	8	0	0.0940	0.934	1.000
290	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	8162661	24	8	23	6	7	3	1	11	2	0	0.360	0.934	1.000
291	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	25	AKT1(1), CISH(1), IARS(1), IL13RA1(1), INPP5D(2), JAK2(3), JAK3(1), PI3(1), PPP1R13B(1), RPS6KB1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3), TYK2(5)	11348119	28	12	28	4	8	2	3	10	5	0	0.0791	0.935	1.000
292	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(2), APOBEC1(2), APOBEC3F(1), APOBEC4(2)	2397289	7	5	7	4	1	1	0	4	1	0	0.881	0.935	1.000
293	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	26	BRAF(3), CPEB1(3), ERBB2(1), ERBB4(4), ETS1(3), ETV6(2), ETV7(1), FMN2(2), KRAS(1), MAPK1(1), MAPK3(1), NOTCH2(10), NOTCH3(4), NOTCH4(8), PIWIL2(3), PIWIL3(1), RAF1(1), SOS1(1), SOS2(4), SPIRE1(1), SPIRE2(2)	14913399	57	26	57	15	15	11	10	11	8	2	0.172	0.935	1.000
294	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	15	AGT(2), AGTR2(1), EDNRB(1), EGF(3), NFKB1(1), PLCG1(6), PRKCA(3), RELA(1)	5847930	18	9	17	7	6	3	2	5	1	1	0.611	0.936	1.000
295	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ESR1(1), GREB1(5), MTA3(2)	3562644	8	3	8	1	5	0	1	2	0	0	0.191	0.939	1.000
296	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CBS(3), CTH(1), GGT1(4), LCMT1(2), LCMT2(1), MARS(4), MARS2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SCLY(2)	8161124	26	8	26	4	5	7	4	9	1	0	0.0343	0.939	1.000
297	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(1), ARHGDIB(1), BIRC2(1), CASP1(1), CASP10(1), CASP4(1), CYCS(2), DFFA(1), LMNA(2), LMNB2(2), PRF1(1)	6310337	14	5	14	4	3	5	1	4	1	0	0.379	0.942	1.000
298	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	24	ABL1(4), ATM(4), ATR(4), CCNA1(1), CCND1(1), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), E2F1(1), RB1(4), SKP2(2), TGFB2(2), TGFB3(1)	9591398	30	10	30	6	8	4	5	7	6	0	0.122	0.943	1.000
299	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	HSD17B2(1), HSD17B4(2)	2649945	3	3	3	4	1	0	0	1	1	0	0.986	0.947	1.000
300	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), FDXR(1), SHMT1(1)	5244576	8	3	8	1	3	4	0	0	0	1	0.165	0.948	1.000
301	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	14	FLT3(2), IL6(1), IL9(1), KITLG(2), TGFB2(2), TGFB3(1)	2657254	9	3	9	3	2	1	1	3	2	0	0.579	0.950	1.000
302	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	EPOR(1), JAK2(3), NFKB1(1), NFKBIA(1), RELA(1), SOD2(1)	4135148	8	3	8	5	2	1	0	3	2	0	0.866	0.950	1.000
303	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4)	3521477	10	7	10	5	4	4	0	1	1	0	0.617	0.951	1.000
304	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(2), FCGR3A(1), IL1B(1), SPN(1), TGFB2(2), TNFRSF1B(2), TNFRSF8(1), TNFSF8(1)	4273265	13	5	13	4	5	3	1	2	2	0	0.349	0.951	1.000
305	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCK1(1), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1)	17153168	46	15	46	13	15	6	10	10	4	1	0.144	0.953	1.000
306	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTB(1), ARHGEF2(3), CDH1(3), CLDN1(1), CTTN(1), EZR(1), FYN(1), HCLS1(1), ITGB1(2), NCK1(1), NCL(1), OCLN(1), PRKCA(3), ROCK1(2), ROCK2(2), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1), WAS(2), WASL(1), YWHAQ(1), YWHAZ(1)	17153168	46	15	46	13	15	6	10	10	4	1	0.144	0.953	1.000
307	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(1), PTPRC(4)	3692971	11	7	11	5	4	4	0	2	1	0	0.587	0.954	1.000
308	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(1), BRAF(3), DAG1(1), EPHB2(1), ITPR1(2), ITPR2(11), ITPR3(6), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PITX2(3), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT3(1)	18265020	49	16	49	10	12	5	11	15	6	0	0.0531	0.954	1.000
309	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOB(1), FBP1(1), FBP2(2), GOT1(2), ME1(1), ME3(1), PKLR(1), TKT(2), TKTL2(1), TPI1(1)	6596962	13	6	13	2	5	2	1	3	2	0	0.183	0.955	1.000
310	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(1), HDAC9(1), MEF2A(2), MEF2B(1), YWHAH(1)	2512805	6	2	6	4	1	2	0	0	3	0	0.937	0.955	1.000
311	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(4), ATR(4), CHEK1(3), CHEK2(6), YWHAH(1)	4962059	18	8	16	7	4	4	4	3	3	0	0.747	0.955	1.000
312	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	MAPK1(1), MAPK3(1), NFKB1(1), NFKBIA(1), PLCB1(2), PRKCA(3), RAF1(1), RELA(1)	5073779	11	6	11	6	2	0	1	3	3	2	0.747	0.956	1.000
313	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), OAT(1), ODC1(2), SMS(1)	5728120	18	6	18	5	3	4	0	3	8	0	0.476	0.957	1.000
314	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL6(1), STAT1(2), STAT3(1)	3980292	6	3	6	3	2	0	0	3	0	1	0.839	0.957	1.000
315	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACSL1(3), ACSL3(2), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), SCP2(1), SLC25A20(1)	5504660	15	6	15	6	0	5	0	4	6	0	0.700	0.958	1.000
316	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(1), AR(3), ESR1(1), ESR2(3), ESRRA(2), HNF4A(1), NPM1(2), NR1D1(1), NR1D2(1), NR1H2(1), NR1H3(4), NR1I2(1), NR2C2(1), NR2E1(1), NR2F2(1), NR3C1(2), NR4A1(1), NR4A2(1), NR5A1(1), PGR(2), PPARA(2), PPARG(1), ROR1(2), RXRA(1), RXRG(3), VDR(1)	13724367	41	13	40	10	14	7	6	10	4	0	0.0920	0.960	1.000
317	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(1), ADRA1B(2), ADRB2(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), DRD3(1), DRD5(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1)	8363588	30	15	30	10	9	4	4	6	7	0	0.305	0.960	1.000
318	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRS3(1), DHRS7(1), ESCO2(2), PNPLA3(1), SH3GLB1(3)	5407039	10	3	9	1	5	2	0	2	1	0	0.161	0.961	1.000
319	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	FUT8(3), ST3GAL1(1), ST3GAL4(1)	2565737	5	4	5	3	2	2	0	0	1	0	0.829	0.961	1.000
320	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(1), JAK2(3), JAK3(1), PIAS1(1), PIAS3(1), PTPRU(2), REG1A(1), SOAT1(1)	4479069	11	8	11	7	2	1	0	5	3	0	0.937	0.962	1.000
321	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(2), ALOX15(1), CBR3(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2U1(1), CYP4A11(1), CYP4F3(4), EPHX2(2), GGT1(4), GPX1(2), GPX4(1), LTA4H(3), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGES2(1), PTGS1(2), PTGS2(2)	12725384	47	31	46	13	12	7	7	12	9	0	0.239	0.963	1.000
322	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	11	AKT1(1), CHRNB1(1), CHRNG(1), MUSK(4), PTK2(1), YWHAH(1)	4095497	9	4	9	5	2	0	1	3	3	0	0.913	0.965	1.000
323	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(4), CES1(1), CES2(1), UGT1A1(6)	7474823	12	6	12	4	3	2	3	3	1	0	0.505	0.966	1.000
324	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(2), DHRS3(1), DHRS7(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1)	4916153	15	3	14	3	6	2	1	5	1	0	0.176	0.968	1.000
325	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(2), CDH1(3), CREBBP(8), EP300(3), MAPK3(1), SKIL(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2)	8394581	25	7	25	4	5	4	1	12	2	1	0.142	0.968	1.000
326	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	CEBPB(1), CLOCK(2), CRY1(2), EIF4G2(1), ETV6(2), HERPUD1(1), HSPA8(1), IDI1(1), NCKAP1(2), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(1), PURA(1), SF3A3(1), TOB1(1), TUBB3(3), UGP2(1), ZFR(1)	11933393	35	12	35	7	5	9	6	11	4	0	0.117	0.969	1.000
327	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	17	EGF(3), MAPK1(1), MAPK3(1), PTPRB(5), RAF1(1), RASA1(4), SHC1(1), SOS1(1), SPRY1(1), SPRY4(1)	7290950	19	10	19	5	6	0	2	4	6	1	0.432	0.970	1.000
328	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	19	AKT1(1), EIF4A1(3), EIF4A2(1), EIF4E(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK3(1), PABPC1(4), PRKCA(3), RPS6KB1(1)	7703173	28	13	28	8	6	7	3	3	7	2	0.365	0.972	1.000
329	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(3), ATP6AP1(1), ATP6V0C(1), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP7A(5), ATP7B(2), COX7A1(1), COX7B(1), NDUFA10(3), NDUFS1(2), NDUFV1(2), NDUFV2(1), SDHA(1), SHMT1(1), UQCRC1(2), UQCRH(2)	12489967	32	10	32	5	4	6	3	12	6	1	0.0553	0.973	1.000
330	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN2(6), ACTN3(1), BCAR1(1), CSK(1), CTNNA2(2), PTK2(1), VCL(1)	6264821	13	4	13	3	6	3	0	3	1	0	0.239	0.973	1.000
331	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(2), AGTR2(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), F2(2), FYN(1), GNA11(1), GNAI1(1), JAK2(3), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MYLK(3), PLCG1(6), PRKCA(3), RAF1(1), SHC1(1), SOS1(1), STAT1(2), STAT3(1)	13618366	37	14	36	9	11	5	3	7	8	3	0.134	0.974	1.000
332	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	15	ADRB2(1), AKT1(1), ANXA1(2), GNAS(3), NFKB1(1), NOS3(5), NR3C1(2), RELA(1)	4603768	16	10	16	7	9	0	2	3	2	0	0.765	0.975	1.000
333	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B10(2), G6PC(3), G6PC2(1), GAA(5), GANC(3), GCK(1), GLA(1), GLB1(1), HK1(3), HK2(2), HK3(1), LCT(5), MGAM(4), PFKL(2), UGP2(1)	12636199	35	13	35	10	19	4	2	7	3	0	0.224	0.975	1.000
334	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CXCR4(1), MAPK8(1), PLCG1(6), PRKCA(3)	4506142	11	8	10	5	2	3	3	1	1	1	0.632	0.975	1.000
335	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B10(2), ALDOB(1), FBP1(1), FBP2(2), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MPI(1), MTMR1(1), MTMR2(2), MTMR6(1), PFKFB1(3), PFKFB2(1), PFKFB3(2), PFKL(2), PGM2(5), SORD(1), TPI1(1), TSTA3(1)	12164345	35	12	35	7	15	9	2	4	5	0	0.0308	0.976	1.000
336	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	82	ABL1(4), AKT1(1), ARAF(1), AREG(2), BRAF(3), BTC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CBLB(1), CBLC(1), CDKN1B(1), CRKL(1), EGF(3), ELK1(3), ERBB2(1), ERBB3(2), ERBB4(4), KRAS(1), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NCK1(1), NRAS(1), NRG1(2), NRG2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PRKCA(3), PRKCG(1), PTK2(1), RAF1(1), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), STAT5B(2)	31551010	95	38	94	22	30	13	10	22	18	2	0.0221	0.977	1.000
337	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(2), ALDOB(1), TPI1(1)	1282520	4	1	4	0	0	4	0	0	0	0	0.151	0.978	1.000
338	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	57	BAX(1), BFAR(1), BTK(1), CAD(4), CASP10(1), CASP8AP2(2), CD7(1), CSNK1A1(2), DAXX(2), DFFA(1), DIABLO(1), EPHB2(1), FAF1(3), MAP3K1(2), MAP3K5(2), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MET(6), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), SMPD1(1), TNFRSF6B(1), TPX2(2), TUFM(1)	22563774	58	18	58	13	16	8	7	10	17	0	0.0861	0.978	1.000
339	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(2), DPAGT1(1), DPM1(2), FUT8(3), MAN1A1(2), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), RPN2(1), ST6GAL1(1)	6492770	20	8	20	6	4	5	3	3	5	0	0.391	0.979	1.000
340	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	13	AKT1(1), BCAR1(1), CDKN1B(1), ITGB1(2), MAPK1(1), MAPK3(1), PTK2(1), SHC1(1), SOS1(1)	4804903	10	3	10	4	3	0	1	1	4	1	0.667	0.979	1.000
341	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA2(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1D1(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CEL(1), CYP27A1(1), CYP7A1(1), SOAT2(2), SRD5A1(1)	7590964	31	14	31	11	11	4	2	9	5	0	0.435	0.980	1.000
342	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(2), GLA(1), HEXA(1), ST3GAL1(1), ST3GAL4(1)	3307389	6	3	6	5	3	0	0	2	1	0	0.978	0.980	1.000
343	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	18	HLA-A(1), ITGB1(2), KLRC1(1), KLRC2(1), LAT(1), MAPK3(1), PAK1(2), RAC1(1), VAV1(4)	4857956	14	5	14	5	2	1	3	2	5	1	0.554	0.980	1.000
344	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(2), F2(2), FGA(4), FGB(1), PLAT(1), PLAU(1), PLG(3), SERPINB2(1), SERPINE1(1)	4384847	17	8	17	6	8	2	1	2	4	0	0.432	0.981	1.000
345	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(3), AKT1(1), ATM(4), BAX(1), CPB2(1), CSNK1A1(2), CSNK1D(1), IGFBP3(1), MAPK8(1), MDM2(2)	6509771	17	7	17	6	4	2	3	6	2	0	0.547	0.981	1.000
346	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	17	CABIN1(6), CAPNS1(1), CAPNS2(1), EP300(3), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), PRKCA(3)	7654897	21	6	21	8	7	3	4	5	1	1	0.573	0.981	1.000
347	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PCYT1B(1), PRMT2(2), PRMT5(1), PRMT6(1)	4600473	12	2	12	3	3	2	1	5	1	0	0.353	0.981	1.000
348	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(9), C5(4), C6(2), C7(4), ICAM1(2), IL6(1), ITGA4(2), ITGAL(1), ITGB1(2), ITGB2(1), SELP(2), SELPLG(1), VCAM1(1)	8109986	32	17	32	12	8	5	5	8	6	0	0.455	0.981	1.000
349	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TOB1(1), TOB2(1)	3451115	10	4	10	2	3	3	1	3	0	0	0.254	0.982	1.000
350	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), FUT2(2), FUT5(2), FUT6(2), ST3GAL6(2)	5266985	16	9	16	7	5	1	3	5	2	0	0.768	0.983	1.000
351	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	B3GALT5(1), FUT2(2), GLA(1), HEXA(1), ST3GAL1(1)	3510574	6	2	6	6	3	0	0	2	1	0	0.990	0.983	1.000
352	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(2), CA1(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUL(1), HAL(1)	6216215	15	9	15	6	2	5	1	3	4	0	0.660	0.983	1.000
353	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CTH(1), GOT1(2), LDHB(1), SULT1B1(2), SULT1C2(3)	4102936	9	2	9	1	1	3	0	3	2	0	0.262	0.983	1.000
354	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GPHN(1), NSF(2)	3905847	20	11	20	8	5	7	1	5	2	0	0.575	0.984	1.000
355	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	ABP1(2), CES1(1), ESCO2(2), LIPA(2), PLA1A(2), PNPLA3(1), SH3GLB1(3)	8278529	13	4	13	4	3	3	2	3	2	0	0.488	0.985	1.000
356	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	ALDOB(1), FBP1(1), FBP2(2), GCK(1), GMDS(1), GMPPA(1), HK1(3), HK2(2), HK3(1), MPI(1), PFKFB1(3), PFKFB3(2), SORD(1), TPI1(1)	7830685	21	7	21	4	8	8	1	2	2	0	0.0317	0.985	1.000
357	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1)	4185003	8	3	8	3	3	4	0	0	1	0	0.527	0.985	1.000
358	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	18	AKT1(1), EIF4A1(3), EIF4A2(1), EIF4B(1), EIF4E(1), EIF4G1(3), EIF4G2(1), EIF4G3(4), RPS6KB1(1), TSC1(2), TSC2(2)	7528625	20	11	20	6	4	6	4	3	3	0	0.362	0.986	1.000
359	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(2), ACYP1(1), DHRS2(2), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(1), ESCO2(2), GCDH(1), ITGB1BP3(1), PNPLA3(1), SH3GLB1(3)	8476043	19	6	18	7	8	3	1	4	3	0	0.556	0.988	1.000
360	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), HLA-DRA(2), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1)	4145486	8	6	8	6	2	1	1	3	1	0	0.946	0.988	1.000
361	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(2), HYI(1), MTHFD1(2), MTHFD1L(1)	4383062	8	3	8	3	3	4	0	0	1	0	0.520	0.988	1.000
362	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	15	AKT1(1), CREB1(1), MAPK1(1), MAPK3(1), MAPK7(3), MEF2A(2), MEF2B(1), PLCG1(6), RPS6KA1(2), SHC1(1)	4953903	19	9	18	7	3	5	1	5	4	1	0.539	0.989	1.000
363	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(2), COL4A4(4), COL4A5(3), COL4A6(5), SLC23A2(3), SLC2A1(1), SLC2A3(2)	8195407	21	9	21	8	7	7	1	2	3	1	0.459	0.989	1.000
364	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(1), ALOX5AP(1), GGT1(4), LTA4H(3), PLA2G6(2), PTGS1(2), PTGS2(2)	4928859	15	8	15	6	2	5	3	3	2	0	0.592	0.989	1.000
365	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2D(1), CAMK2G(2), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFAT5(3), PDE6B(3), PDE6C(6), SLC6A13(2), TF(1)	11705089	39	16	39	13	13	8	7	6	5	0	0.259	0.989	1.000
366	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CFL1(1), GNAS(3), LIMK1(2), MAPK1(1), MAPK3(1), MYL2(1), NOX1(1), PIK3C2G(1), PLCB1(2), PRKCA(3), PTK2(1), RAF1(1), ROCK2(2)	8186049	21	13	21	9	3	1	2	7	6	2	0.814	0.990	1.000
367	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	40	AKT1(1), BRAF(3), CREB1(1), CREBBP(8), CRKL(1), DAG1(1), EGR1(1), EGR3(1), ELK1(3), FRS2(1), MAP1B(5), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), OPN1LW(1), PIK3C2G(1), PIK3CD(1), PTPN11(6), RPS6KA3(2), SHC1(1), TH(1)	15533516	50	21	49	16	13	7	6	17	6	1	0.274	0.990	1.000
368	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(1)	5234270	10	2	10	3	2	3	1	3	1	0	0.524	0.990	1.000
369	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CD3D(1), IL12B(2), IL12RB1(1), IL12RB2(1), JAK2(3), MAPK8(1), STAT4(2), TYK2(5)	6100376	16	6	16	8	6	3	1	4	2	0	0.823	0.990	1.000
370	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	14	AKT1(1), ELK1(3), MAP2K2(1), NGFR(1), PIK3CD(1), SHC1(1), SOS1(1)	4553788	9	3	9	4	3	2	0	3	1	0	0.672	0.991	1.000
371	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(2), GNAI1(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), PLA2G4A(4), PLCB1(2), PRKCA(3), PTGS1(2), PTK2(1), RAF1(1)	7967874	22	13	22	9	2	1	4	8	5	2	0.726	0.991	1.000
372	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(2), CA1(1), CA13(1), CA5A(1), CPS1(4), CTH(1), GLS(1), GLUD1(3), GLUD2(1), GLUL(1), HAL(1)	6949108	17	10	17	8	2	6	1	4	4	0	0.776	0.992	1.000
373	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(10), ACACB(5), FASN(1), MCAT(1), OXSM(1)	5167358	18	10	17	8	4	4	2	6	2	0	0.675	0.992	1.000
374	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	MAP3K1(2), MAP3K5(2), MAP4K5(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), TNFRSF9(2)	6318123	11	7	11	5	4	2	2	1	2	0	0.682	0.992	1.000
375	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(1), MAF(1), MAP2K3(2), NFATC1(1), NFATC2(4), PRKACG(1), PRKAR1A(1)	3969455	11	6	11	6	6	1	0	3	1	0	0.783	0.993	1.000
376	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IRS1(2), JAK3(1), RPS6KB1(1), SHC1(1), STAT6(3)	4838413	9	5	9	4	2	2	0	4	1	0	0.725	0.993	1.000
377	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGW(1), PIGZ(1)	7785233	19	4	19	5	9	3	3	4	0	0	0.191	0.993	1.000
378	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(3), MARS(4), MARS2(1), MTR(2)	5698444	22	7	22	9	6	5	0	8	1	2	0.540	0.994	1.000
379	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ACTR3(1), ARPC1B(1), ARPC3(1), NCK1(1), NCKAP1(2), RAC1(1), WASF1(1), WASF3(2), WASL(1)	4995003	12	3	12	3	2	2	1	5	2	0	0.376	0.994	1.000
380	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	48	ACOX1(1), APOA1(1), CD36(3), CITED2(1), CREBBP(8), EHHADH(1), EP300(3), HSD17B4(2), LPL(2), MAPK1(1), MAPK3(1), ME1(1), NCOA1(1), NCOR1(8), NCOR2(3), NFKBIA(1), NR1H3(4), NRIP1(1), PDGFA(1), PPARA(2), PRKACG(1), PRKAR1A(1), PRKCA(3), PTGS2(2), RB1(4), RELA(1), RXRA(1), STAT5B(2)	19435018	61	26	60	19	10	10	6	18	14	3	0.454	0.994	1.000
381	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACPP(1), ALPP(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), PON1(3)	9546704	19	14	19	7	8	1	1	4	5	0	0.630	0.995	1.000
382	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(2), CD33(1), CD7(1), IFNB1(1), IL12B(2), TLR7(3), TLR9(1)	6078194	11	5	10	8	1	2	2	4	2	0	0.954	0.995	1.000
383	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), EPRS(2), FARS2(2), GARS(2), HARS(1), IARS(1), LARS(3), MARS(4), MARS2(1), QARS(1), RARS(2), WARS2(2), YARS(1)	10492055	23	7	23	6	4	7	1	8	3	0	0.361	0.995	1.000
384	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AP2A1(1), AP2M1(1), BIN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(7)	7009110	19	6	19	5	6	2	2	4	5	0	0.331	0.995	1.000
385	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT7(1), CHST1(1), CHST4(1), FUT8(3), ST3GAL1(1), ST3GAL4(1)	4064224	8	6	8	7	3	3	1	0	1	0	0.947	0.995	1.000
386	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	17	ADCY1(1), ARHGEF1(1), F2(2), GNAI1(1), PLCB1(2), PRKCA(3), ROCK1(2)	7208282	12	7	12	7	3	1	2	2	3	1	0.810	0.995	1.000
387	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	4	FURIN(1)	1697678	1	1	1	0	1	0	0	0	0	0	0.650	0.996	1.000
388	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(2), AGPAT3(1), CDS2(2), CHAT(3), CHKB(1), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), ESCO2(2), ETNK2(2), GNPAT(1), GPAM(1), PCYT1B(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(5), PNPLA3(1), PPAP2A(2), PPAP2C(1), PTDSS1(1), SH3GLB1(3)	21329299	52	17	52	14	17	12	5	10	8	0	0.0984	0.996	1.000
389	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(1), CRKL(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), PAK1(2), PLCG1(6), PRKCA(3), RAC1(1), RAF1(1), SHC1(1), SOS1(1)	9316962	25	12	24	7	7	5	2	2	7	2	0.210	0.997	1.000
390	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(1), APAF1(1), ATM(4), BAX(1), CYCS(2), PRKCA(3), PTK2(1), STAT1(2), TLN1(2)	8677719	17	6	17	5	4	2	1	6	2	2	0.479	0.997	1.000
391	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(2), TRAF3(1)	7340558	13	6	13	7	6	1	1	1	4	0	0.772	0.997	1.000
392	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	IKBKAP(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), TNFAIP3(1), TRAF3(1)	5930476	9	4	9	8	5	0	1	1	2	0	0.959	0.997	1.000
393	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(2), ACADM(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), HIBCH(1), MLYCD(3), SMS(1), SRM(1)	8826247	36	14	36	13	15	6	3	7	5	0	0.364	0.997	1.000
394	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(2), ADRBK2(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CLCA1(2), CLCA2(2), CNGA3(2), CNGB1(1), GNAL(1), PDE1C(5), PRKACG(1), PRKG1(1), PRKG2(1)	9969387	25	7	25	9	11	4	1	3	6	0	0.407	0.997	1.000
395	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH6A1(2), AOX1(3), BCKDHA(1), ECHS1(2), EHHADH(1), HIBADH(1), MCCC1(1), MCCC2(5), MUT(1), OXCT1(1), PCCB(2)	11775989	39	15	38	13	12	12	2	6	7	0	0.307	0.997	1.000
396	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	76	ABL1(4), ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), ARHGEF6(3), BCAR1(1), BRAF(3), CDKN2A(2), DOCK1(1), EPHB2(1), FYN(1), GRB7(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), MAP3K11(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MRAS(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PIK3CB(1), PKLR(1), PLCG1(6), PLCG2(7), PTK2(1), RAF1(1), RALA(1), ROCK1(2), ROCK2(2), SHC1(1), SOS1(1), SOS2(4), TLN1(2), TLN2(4), WAS(2)	38956980	107	38	106	26	31	14	13	30	19	0	0.0290	0.998	1.000
397	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(1), BIRC2(1), CASP10(1), DFFA(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(1)	5968998	9	3	9	4	2	3	1	3	0	0	0.674	0.998	1.000
398	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN2(6), ACTN3(1), CAPNS1(1), CAPNS2(1), ITGA1(2), ITGB1(2), ITGB3(2), PTK2(1), RAC1(1), SPTAN1(2), TLN1(2)	9324741	21	6	21	6	6	2	4	5	4	0	0.349	0.998	1.000
399	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	24	ADCY1(1), AKT1(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), GNAS(3), MAPK1(1), MAPK3(1), PRKACG(1), PRKAR1A(1), PRKCA(3), RAC1(1), RPS6KA1(2), SOS1(1)	8264508	21	9	21	5	5	1	1	4	8	2	0.332	0.998	1.000
400	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CRADD(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TANK(1), TRADD(1)	7883288	13	8	13	8	6	3	0	1	3	0	0.858	0.998	1.000
401	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(2), CD1A(2), CD1B(3), CD1E(3), CD22(1), CD33(1), CD36(3), CD3D(1), CD4(1), CD44(2), CD55(1), CD7(1), CR1(4), CR2(3), CSF1R(3), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), GP5(1), GP9(1), HLA-DRA(2), HLA-DRB5(3), IL1B(1), IL1R1(1), IL1R2(2), IL3RA(2), IL5RA(1), IL6(1), ITGA1(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGAM(1), ITGB3(2), KIT(3), KITLG(2), MME(2), MS4A1(2), TFRC(1), TPO(3)	26606506	84	26	84	25	18	20	8	25	13	0	0.110	0.998	1.000
402	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA2(2), ACAD8(3), ACAD9(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CEL(1), CYP27A1(1), CYP7A1(1), LIPA(2), SLC27A5(3), SOAT1(1), SOAT2(2), SRD5A1(1)	10330337	45	17	45	16	15	5	3	15	7	0	0.527	0.998	1.000
403	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	CYCS(2), SDHA(1), SDHC(1), UQCRC1(2)	2161567	6	3	6	2	0	1	2	3	0	0	0.625	0.998	1.000
404	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CTH(1), GOT1(2), LDHB(1)	2240265	4	1	4	1	1	2	0	1	0	0	0.531	0.998	1.000
405	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	EGR3(1), MAP3K1(2), NFATC1(1), NFATC2(4), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), RELA(1)	9140842	21	12	20	9	7	2	1	7	4	0	0.780	0.998	1.000
406	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOB(1), FBP1(1), FBP2(2), G6PD(2), GPI(2), H6PD(3), PRPS1L1(1), PRPS2(3), RBKS(1), TAL1(1), TALDO1(2), TKT(2)	6676944	21	9	21	8	9	7	0	1	4	0	0.271	0.998	1.000
407	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(1), GLI2(1), GLI3(2), PRKACG(1), PRKAR1A(1), SHH(1), SMO(2), SUFU(1)	5438954	10	4	10	5	1	5	0	3	1	0	0.722	0.998	1.000
408	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	14	AKT1(1), BPNT1(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), RBL2(2), SHC1(1), SOS1(1)	5677865	11	4	11	6	1	2	0	5	2	1	0.839	0.999	1.000
409	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(1), CMAS(1), GFPT1(1), GFPT2(3), GNE(1), GNPDA1(2), GNPNAT1(1), HEXA(1), HK1(3), HK2(2), HK3(1), MTMR1(1), MTMR2(2), MTMR6(1), RENBP(1)	9387718	23	11	23	8	4	7	3	5	4	0	0.519	0.999	1.000
410	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR24(2), DHCR7(3), FDFT1(1), IDI1(1), MVD(2), NSDHL(2), SQLE(1)	6290354	14	6	14	8	6	1	4	2	1	0	0.848	0.999	1.000
411	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(1), ATP6V0C(1), GART(3), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1)	5848674	18	3	18	8	5	6	2	3	1	1	0.585	0.999	1.000
412	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	29	ACO2(2), FH(1), IDH3B(1), PC(1), PDHA1(2), PDHA2(4), PDK1(2), PDK3(3), PDK4(1), PDP2(1), SDHA(1), SDHC(1), SUCLG2(1)	9016017	21	10	21	9	3	4	4	6	4	0	0.647	0.999	1.000
413	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(2), ALAS1(1), UROS(1)	2487800	4	1	4	1	2	0	0	2	0	0	0.640	0.999	1.000
414	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ADCY3(2), ADCY9(3), ARF1(1), ARF6(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), ERO1L(1), GNAS(3), PLCG1(6), PLCG2(7), PRKCA(3), SEC61A1(1)	12073310	36	20	35	11	17	7	3	4	4	1	0.247	0.999	1.000
415	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	25	ACLY(3), ACO1(2), ACO2(2), FH(1), IDH3B(1), OGDHL(2), PC(1), PCK1(3), SDHA(1), SDHC(1), SUCLG2(1)	9231989	18	10	18	7	6	4	2	3	3	0	0.463	0.999	1.000
416	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(2), ELK1(3), IL2RB(1), JAK3(1), MAPK3(1), MAPK8(1), RAF1(1), SHC1(1), SOS1(1), STAT5B(2)	7623685	14	8	14	6	1	4	0	6	2	1	0.646	0.999	1.000
417	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(2), CREB1(1), DAG1(1), EPHB2(1), MAPK1(1), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1)	9348084	15	7	15	5	3	2	2	4	4	0	0.453	0.999	1.000
418	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(1), BIRC2(1), CASP10(1), CFLAR(1), CYCS(2), DFFA(1), GAS2(1), LMNA(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), SPTAN1(2), TRADD(1)	10903246	18	7	18	7	5	3	1	5	4	0	0.611	0.999	1.000
419	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(5), AOX1(3), DDC(1), ESCO2(2), GOT1(2), GSTZ1(2), HGD(3), HPD(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PNPLA3(1), PRMT2(2), PRMT5(1), PRMT6(1), SH3GLB1(3), TAT(1), TH(1), TPO(3), TYR(4), TYRP1(2)	19440047	60	19	60	20	19	8	6	20	7	0	0.331	0.999	1.000
420	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), CREB1(1), ELK1(3), GNAI1(1), GNAS(3), MAPK3(1), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), PLCG1(6), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3), RAF1(1), RPS6KA3(2)	11392110	36	17	35	12	10	4	4	8	8	2	0.471	0.999	1.000
421	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(2), ELK1(3), MAP2K2(1), MAP3K1(2), MAPK1(1), MAPK3(1), MAPK8(1), MEF2A(2), MEF2B(1), PAK1(2), PRKCA(3), PTK2(1), RAC1(1), RAF1(1), SHC1(1), SOS1(1)	10086750	24	7	24	9	5	4	1	4	8	2	0.547	1.000	1.000
422	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BIRC2(1), CFLAR(1), MAP3K3(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1)	8870879	15	5	15	7	8	1	1	1	4	0	0.728	1.000	1.000
423	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	DFFA(1), TOP2A(4), TOP2B(1)	2862465	6	1	6	3	3	1	1	0	1	0	0.767	1.000	1.000
424	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	14	CREBBP(8), EP300(3), FYN(1), JAK3(1), STAT5B(2)	7908816	15	6	15	7	4	1	0	8	2	0	0.870	1.000	1.000
425	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH3A1(5), AOX1(3), DDC(1), GOT1(2), GSTZ1(2), HGD(3), HPD(1), TAT(1), TH(1), TPO(3), TYR(4)	10371892	40	17	40	15	16	3	4	12	5	0	0.483	1.000	1.000
426	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	30	MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK5(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PIK3CD(1), TRAF3(1), TRAF5(1)	9722789	23	9	23	9	8	3	2	5	4	1	0.465	1.000	1.000
427	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(2), MEF2B(1), PPARA(2), PPP3CA(1), PPP3CC(1), SLC2A4(1), YWHAH(1)	6611233	19	4	19	6	5	6	0	2	6	0	0.427	1.000	1.000
428	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	20	ADCY1(1), AKT1(1), GNAI1(1), ITGAV(2), ITGB3(2), MAPK1(1), MAPK3(1), PDGFA(1), PDGFRA(8), PLCB1(2), PRKCA(3), PTK2(1), RAC1(1), SMPD1(1), SMPD2(1)	7743250	27	13	27	10	4	4	3	4	10	2	0.554	1.000	1.000
429	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(1), ARHGEF1(1), MYL2(1), MYLK(3), PLCB1(2), PRKCA(3), ROCK1(2)	6744538	13	5	13	6	5	1	3	2	1	1	0.670	1.000	1.000
430	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(4), CDK4(1), CDKN1B(1), CEBPB(1), DMC1(2), EGR1(1), ESR2(3), FSHR(2), GJA4(1), MLH1(4), MSH5(1), NCOR1(8), NR5A1(1), NRIP1(1), PGR(2), PRLR(1), SMPD1(1), VDR(1), ZP2(1)	11455712	37	13	37	12	9	7	2	12	6	1	0.532	1.000	1.000
431	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(1), FBXW7(1), ITK(1), LAT(1), MAPK1(1), NCK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PLCG1(6), PTPRC(4), RAF1(1), RASGRP2(2), RASGRP3(1), RASGRP4(1), SOS1(1), SOS2(4), VAV1(4), ZAP70(3)	18181796	55	20	54	15	17	11	4	11	12	0	0.148	1.000	1.000
432	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(3), EXT2(2), EXTL1(2), EXTL3(1), HS6ST2(3), NDST1(2), NDST2(2), NDST3(2), NDST4(1)	6756766	18	10	18	8	8	1	3	5	1	0	0.723	1.000	1.000
433	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	7	ACO2(2), FH(1), SDHA(1)	2819138	4	2	4	5	2	0	1	0	1	0	0.970	1.000	1.000
434	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(1), BAX(1), BIRC2(1), CYCS(2), FAS(1), MAP3K1(2), MAP3K14(1), MAPK10(1), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1)	11938765	21	11	21	9	6	2	2	5	6	0	0.703	1.000	1.000
435	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(4), ATR(4), BRCA1(1), BRCA2(4), CHEK1(3), CHEK2(6), FANCA(2), FANCC(1), FANCD2(3), FANCE(2), HUS1(1), MRE11A(2), RAD1(2), RAD17(2), RAD50(2), RAD9A(1), TREX1(1)	14157292	41	15	39	11	9	9	7	10	6	0	0.283	1.000	1.000
436	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(1), CHRM1(1), CHRNA1(2), FLT1(3), FLT4(3), KDR(6), NOS3(5), PDE3A(2), PRKACG(1), PRKAR1A(1), PRKG1(1), PRKG2(1), RYR2(11), SLC7A1(1), TNNI1(1)	13209940	40	21	40	14	11	6	7	10	6	0	0.376	1.000	1.000
437	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(3), ACVR1B(2), ACVR1C(1), ACVR2A(1), ACVRL1(3), AMHR2(1), BMP4(2), BMP5(3), BMP6(1), CHRD(1), CREBBP(8), CUL1(1), DCN(1), E2F5(1), EP300(3), GDF5(1), GDF6(1), INHBA(1), INHBB(1), INHBE(1), LTBP1(4), MAPK1(1), MAPK3(1), NODAL(1), PITX2(3), PPP2CB(1), PPP2R2C(3), RBL1(2), RBL2(2), ROCK1(2), ROCK2(2), RPS6KB1(1), RPS6KB2(2), SMAD1(3), SMAD2(3), SMAD3(2), SMAD5(1), SMAD7(2), SMAD9(2), SMURF1(1), SMURF2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), THBS1(1), THBS2(4), THBS3(2), THBS4(3)	32296175	93	26	93	26	30	14	11	26	11	1	0.0644	1.000	1.000
438	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), SHC1(1), SOS1(1)	2889427	3	2	3	2	0	0	0	1	2	0	0.854	1.000	1.000
439	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMB8(1)	2857245	7	1	7	1	2	1	1	3	0	0	0.328	1.000	1.000
440	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(2), CKM(1), EIF4E(1), FBL(1), LDHB(1), NCL(1)	2914310	7	1	7	2	2	2	1	1	1	0	0.402	1.000	1.000
441	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	DLG4(3), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), NOS1(2), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3)	8347480	25	15	25	10	8	4	2	6	4	1	0.572	1.000	1.000
442	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11B1(2), HSD11B1(1)	3012109	4	3	4	3	1	0	1	1	1	0	0.887	1.000	1.000
443	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1D1(1), CYP11B1(2), HSD11B1(1)	3012109	4	3	4	3	1	0	1	1	1	0	0.887	1.000	1.000
444	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	44	AKT1(1), BCR(1), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(3), CSK(1), DAG1(1), FLOT1(1), FLOT2(1), INPP5D(2), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), NFATC1(1), NFATC2(4), PDK1(2), PIK3CD(1), PLCG2(7), PPP1R13B(1), PPP3CA(1), PPP3CC(1), PTPRC(4), RAF1(1), SHC1(1), SOS1(1), SOS2(4), VAV1(4)	22927526	70	27	70	22	23	11	9	19	7	1	0.203	1.000	1.000
445	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	54	ASH1L(4), ASH2L(1), CTCFL(2), DOT1L(2), EHMT1(4), EHMT2(2), EZH1(3), EZH2(1), HCFC1(2), HSF4(1), JMJD6(2), KDM6A(2), MEN1(1), MLL(7), MLL2(19), MLL3(12), MLL5(2), NSD1(2), OGT(6), PAXIP1(1), PPP1CB(1), PRDM2(3), PRDM7(2), PRMT5(1), PRMT6(1), SATB1(2), SETD1A(1), SETD2(6), SETD7(3), SETD8(1), SETDB1(1), SETDB2(1), SETMAR(2), STK38(1), SUV39H1(1), SUV420H1(2), WHSC1L1(3)	38110270	108	38	108	29	29	18	15	31	15	0	0.100	1.000	1.000
446	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	20	ARHGAP5(1), DIAPH1(3), FYN(1), GSN(1), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), TLN1(2)	10965649	23	8	23	7	7	1	3	6	5	1	0.348	1.000	1.000
447	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(3), APC(2), AXIN1(1), BMP10(1), BMP4(2), BMP5(3), CHRD(1), FZD1(1), MYL2(1), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2)	11869396	21	6	21	4	8	4	2	5	2	0	0.113	1.000	1.000
448	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(2), HSD11B1(1), HSD17B2(1), SRD5A1(1), SULT2A1(1), UGT1A1(6), UGT2B15(1), UGT2B4(2)	8939447	20	14	20	9	8	1	5	5	1	0	0.632	1.000	1.000
449	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), CYSLTR2(1), GPR161(1), GPR171(1), GPR34(1)	3208136	5	1	5	7	0	1	1	1	2	0	0.985	1.000	1.000
450	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(1), DUSP4(1), GCK(1), IL1R1(1), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K9(3), MAPK10(1), MAPK7(3), MAPK8(1), MAPK9(1), MYEF2(2), NFATC3(2), NR2C2(1), PAPPA(4), SHC1(1)	16172934	39	17	39	12	12	5	9	9	4	0	0.402	1.000	1.000
451	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(3), EPHB2(1), F2(2), MAP2K5(1), MAPK1(1), MAPK7(3), MAPK8(1), MYEF2(2), PLD1(5), PLD3(1), PTK2(1), RAF1(1), RASAL1(2), TEC(1), VAV1(4)	8962801	30	11	30	10	8	6	1	10	5	0	0.403	1.000	1.000
452	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(6), CAMK4(2), CEBPB(1), CNR1(1), CREBBP(8), CSNK2A1(2), CTLA4(1), EGR3(1), EP300(3), FCGR3A(1), GATA3(1), IFNB1(1), IL1B(1), IL6(1), ITK(1), KPNA5(2), MAPK8(1), MAPK9(1), MEF2A(2), MEF2B(1), MYF5(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB2(1), NFKBIE(1), NUP214(2), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(4), RELA(1), RPL13A(1), SLA(2), SP3(2), TRPV6(3), VAV1(4), VAV2(1), VAV3(5)	29715003	87	27	85	27	20	23	4	23	17	0	0.200	1.000	1.000
453	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	28	AKT1(1), CABIN1(6), CAMK1G(1), HDAC5(1), IGF1R(3), INSR(3), MAPK7(3), MEF2A(2), MEF2B(1), NFATC1(1), NFATC2(4), PPP3CA(1), PPP3CC(1), YWHAH(1)	10128494	29	10	29	11	11	6	2	5	5	0	0.462	1.000	1.000
454	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(2), ALAS1(1), BLVRA(2), COX15(1), CP(3), EARS2(2), EPRS(2), FTH1(3), GUSB(2), HCCS(3), MMAB(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UROS(1)	13816303	48	23	47	15	12	5	12	18	1	0	0.324	1.000	1.000
455	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	32	AKT1(1), CFLAR(1), CRKL(1), E2F1(1), IL2RB(1), IRS1(2), JAK3(1), MAPK1(1), MAPK3(1), RAF1(1), RPS6KB1(1), SHC1(1), SOS1(1), STAT5B(2)	10580001	16	7	16	7	2	4	0	5	4	1	0.626	1.000	1.000
456	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ACTR3(1), ARHGAP4(1), ARHGAP5(1), ARHGEF1(1), ARHGEF11(1), ARPC1B(1), ARPC3(1), BAIAP2(2), CFL1(1), DIAPH1(3), GSN(1), LIMK1(2), MYL2(1), MYLK(3), OPHN1(2), ROCK1(2), TLN1(2), VCL(1)	14813083	28	12	28	9	7	3	3	11	4	0	0.415	1.000	1.000
457	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	APAF1(1), CYCS(2), DAXX(2), FAS(1), MAPKAPK2(1), MAPKAPK3(1)	3705299	8	2	8	4	0	2	2	3	1	0	0.834	1.000	1.000
458	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CAMK1G(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(1), CREB1(1)	3783734	10	2	10	2	4	3	0	0	3	0	0.191	1.000	1.000
459	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	CALR(2), CANX(1), CD4(1), CIITA(1), CREB1(1), CTSB(1), HLA-A(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(3), HLA-E(1), HLA-F(1), HSP90AB1(1), IFI30(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), KIR2DL1(2), KLRC1(1), KLRC2(1), LGMN(1), RFX5(1), RFXANK(1)	15088707	36	16	36	13	6	5	6	12	7	0	0.613	1.000	1.000
460	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(3), ATP4A(3), ATP5B(1), ATP5G2(1), ATP6AP1(1), ATP6V0A2(1), ATP6V0C(1), ATP6V0D2(2), ATP6V1B1(1), ATP6V1B2(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1E2(2), COX15(1), COX17(1), COX7A1(1), COX7B(1), COX7B2(1), NDUFA10(3), NDUFA9(3), NDUFB11(1), NDUFS1(2), NDUFS3(1), NDUFS8(1), NDUFV1(2), NDUFV2(1), NDUFV3(1), SDHA(1), SDHC(1), TCIRG1(1), UQCRC1(2), UQCRH(2)	18218904	46	14	46	15	9	9	5	14	8	1	0.424	1.000	1.000
461	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(1), CDK2(1), CDKN1B(1), CDKN2A(2), CREB1(1), ERBB4(4), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), MET(6), NOLC1(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPP1R13B(1), PREX1(5), PTK2(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SLC2A4(1), SOS1(1), SOS2(4), TSC1(2), TSC2(2), YWHAH(1), YWHAQ(1), YWHAZ(1)	24268143	73	23	72	23	14	11	11	22	15	0	0.343	1.000	1.000
462	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), MBTPS1(1), MBTPS2(2), SCAP(1), SREBF1(2), SREBF2(1)	3916853	8	2	8	3	0	2	2	4	0	0	0.632	1.000	1.000
463	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	APAF1(1), ARHGDIB(1), BIRC2(1), CFLAR(1), CRADD(1), CYCS(2), DAXX(2), DFFA(1), GSN(1), LMNA(2), LMNB2(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK8(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(6), PRKDC(9), PTK2(1), RASA1(4), RB1(4), RELA(1), RIPK1(1), SPTAN1(2), TNFRSF1B(2), TRADD(1)	22532800	56	25	56	16	15	7	8	13	12	1	0.261	1.000	1.000
464	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(1), PSMA2(1), PSMA3(1), PSMA4(1), PSMB2(1), PSMB4(1), PSMC3(1), RPN2(1)	4218635	8	2	8	4	2	2	1	2	1	0	0.813	1.000	1.000
465	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(2), AASDHPPT(1), ACAT2(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ATP6V0C(1), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), PLOD1(2), PLOD2(1), PLOD3(1), SHMT1(1), TMLHE(1)	12105981	36	11	36	13	16	6	3	4	7	0	0.238	1.000	1.000
466	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	46	AKT1(1), BRD4(1), CDKN2A(2), FLOT1(1), FLOT2(1), INPPL1(4), IRS1(2), IRS2(1), IRS4(6), LNPEP(1), MAPK1(1), MAPK3(1), PARD3(1), PARD6A(1), PDK1(2), PIK3CD(1), PPYR1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SLC2A4(1), SORBS1(1), SOS1(1), SOS2(4), YWHAH(1), YWHAQ(1), YWHAZ(1)	17953512	48	17	47	15	8	8	5	17	9	1	0.440	1.000	1.000
467	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(3), DNMT1(3), MTNR1A(1), PTGER4(1), PTGFR(5), TBXA2R(1)	3646401	15	4	15	9	4	2	0	8	1	0	0.908	1.000	1.000
468	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(3), IMPDH1(2), POLB(1), POLD1(1), POLG(1), PRPS2(3), RRM1(3), SRM(1)	4058917	15	5	15	6	5	4	1	3	2	0	0.560	1.000	1.000
469	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), NT5C(2), NT5E(1), NT5M(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1), PRIM1(1), PRIM2(2), RRM1(3), TK2(3), TXNRD2(2), UCK1(2), UMPS(1), UPP1(1), UPP2(2), UPRT(2)	26431402	81	33	80	25	19	14	7	29	12	0	0.273	1.000	1.000
470	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	FYN(1), RELN(6), VLDLR(1)	4586918	8	3	8	8	2	3	0	2	1	0	0.975	1.000	1.000
471	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	MAP3K14(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(1)	4748947	8	2	8	5	2	3	1	1	1	0	0.814	1.000	1.000
472	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1)	4409957	8	3	8	4	4	1	1	2	0	0	0.755	1.000	1.000
473	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN2(6), ACTN3(1), BCAR1(1), BCR(1), CAPNS1(1), CAPNS2(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), PTK2(1), RAF1(1), ROCK1(2), SHC1(1), SOS1(1), TLN1(2), VCL(1)	15394246	31	8	31	11	10	5	4	7	4	1	0.440	1.000	1.000
474	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), ALDH1A3(3), ALDH3A1(5), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP2S1(1), CYP3A7(1), EPHX1(3), GSTA4(1), GSTA5(3), GSTZ1(2), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	18745806	66	31	65	22	19	7	11	22	7	0	0.378	1.000	1.000
475	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1D1(1), ARSD(2), ARSE(2), CYP11B1(2), HSD11B1(1), HSD17B2(1), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), SRD5A1(1), SULT2A1(1), SULT2B1(2), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1)	16427814	49	25	48	18	13	4	10	18	4	0	0.468	1.000	1.000
476	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(1), B3GALT2(1), B3GALT5(1), B3GNT3(1), B3GNT4(2), B3GNT5(4), B4GALNT1(2), B4GALT6(1), FUT2(2), FUT5(2), FUT6(2), PIGA(2), PIGB(1), PIGC(1), PIGG(1), PIGN(1), PIGO(3), PIGQ(4), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL4(1), ST3GAL6(2), ST6GALNAC3(2), ST6GALNAC4(1), ST8SIA5(3), UGCG(2)	15846047	47	17	47	16	18	6	5	12	6	0	0.408	1.000	1.000
477	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(2), CLTA(1), COPA(2), GBF1(2), GPLD1(1)	5307445	9	3	9	4	2	2	1	2	2	0	0.700	1.000	1.000
478	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ASPH(1), CREB1(1), EP300(3), NOS3(5)	5556247	10	3	10	6	5	0	2	2	1	0	0.849	1.000	1.000
479	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1)	5436563	14	2	14	9	3	2	1	7	1	0	0.938	1.000	1.000
480	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), DARS2(2), EARS2(2), EPRS(2), FARS2(2), GARS(2), HARS(1), HARS2(1), IARS(1), IARS2(2), LARS(3), MARS(4), MARS2(1), MTFMT(1), NARS2(1), PARS2(1), QARS(1), RARS(2), RARS2(4), SARS2(2), TARS2(1), VARS(3), VARS2(1), WARS2(2), YARS(1)	17742852	44	11	44	13	6	12	5	15	6	0	0.371	1.000	1.000
481	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	11	APC(2), AXIN1(1), BTRC(1), FZD1(1)	5661021	5	2	5	3	1	1	0	2	1	0	0.897	1.000	1.000
482	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(4), CCNA1(1), CCND1(1), CCNE2(1), CCNG2(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CREB3L1(1), E2F1(1), E2F3(1), E2F5(1), GBA2(1), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MYT1(3), POLE(7), PRIM1(1), RB1(4), RBL1(2), RPA1(2), TNXB(9), WEE1(1)	24904012	63	22	63	21	14	6	10	17	16	0	0.431	1.000	1.000
483	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(2), CLK3(3), CLK4(1), COL2A1(4), CPSF1(2), CPSF3(1), CSTF1(1), CSTF2(1), CSTF3(3), DDIT3(1), DHX16(2), DHX38(3), DHX8(7), DHX9(3), DICER1(2), FUS(2), LOC440563(2), METTL3(2), NCBP1(1), NONO(1), PAPOLA(5), POLR2A(3), PRPF4(1), PRPF4B(2), PRPF8(6), PSKH1(1), PTBP1(1), RBM5(2), RNGTT(1), SF3A3(1), SF3B1(5), SF3B2(1), SNRPA(1), SNRPB2(1), SNRPD3(1), SNRPE(1), SNRPN(1), SPOP(2), SRPK1(1), SRPK2(1), SRRM1(2), SUPT5H(2), U2AF1(2), U2AF2(2), XRN2(3)	34544345	93	34	92	23	28	17	7	25	16	0	0.143	1.000	1.000
484	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	56	BMP4(2), BMP5(3), BMP6(1), BTRC(1), CSNK1A1(2), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G1(1), CSNK1G2(1), GLI1(2), GLI2(1), GLI3(2), HHIP(2), LRP2(12), PRKACG(1), PTCH1(3), RAB23(1), SHH(1), SMO(2), SUFU(1), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1), ZIC2(2)	19881568	57	22	57	20	21	11	8	11	6	0	0.300	1.000	1.000
485	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(2), CDH1(3), CREBBP(8), CSNK2A1(2), CTNNA2(2), CTNNA3(1), EP300(3), ERBB2(1), FARP2(1), FER(1), FGFR1(1), FYN(1), IGF1R(3), INSR(3), IQGAP1(8), LMO7(4), MAPK1(1), MAPK3(1), MET(6), MLLT4(4), NLK(1), PARD3(1), PTPRB(5), PTPRF(3), PTPRJ(3), PTPRM(4), PVRL1(1), PVRL4(2), RAC1(1), RAC2(1), SMAD2(3), SMAD3(2), SORBS1(1), SSX2IP(1), TCF7L2(2), TGFBR1(1), TGFBR2(2), TJP1(4), VCL(1), WAS(2), WASF1(1), WASF3(2), WASL(1), YES1(2)	38301444	116	43	116	30	33	15	12	33	21	2	0.0277	1.000	1.000
486	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CANT1(3), CTPS2(1), DCTD(1), DHODH(2), DPYD(3), DPYS(1), ENTPD1(1), NT5C(2), NT5E(1), NT5M(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), RRM1(3), TK2(3), UCK1(2), UMPS(1), UPP1(1)	18714446	52	17	52	18	15	11	3	18	5	0	0.458	1.000	1.000
487	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), BCAR1(1), CAPN10(3), CAPN11(3), CAPN3(3), CAPN5(2), CAPN6(1), CAPN7(1), CAPN9(3), CAPNS1(1), CSK(1), DOCK1(1), FYN(1), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), MAP2K2(1), MAP2K3(2), MAPK10(1), MAPK12(2), MAPK4(1), MAPK7(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PIK3R2(1), PTK2(1), RAC1(1), RAC2(1), RAPGEF1(3), ROCK1(2), ROCK2(2), SDCCAG8(1), SEPP1(2), SHC1(1), SORBS1(1), SOS1(1), TLN1(2), TNS1(2), VAV2(1), VAV3(5), VCL(1)	43766312	114	35	112	30	34	17	13	28	22	0	0.0533	1.000	1.000
488	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADL(1), ACADM(1), ACOX1(1), ACOX2(2), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ANGPTL4(1), APOA1(1), AQP7(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(1), CYP7A1(1), EHHADH(1), FABP7(1), FADS2(2), GK(1), GK2(3), HMGCS2(2), LPL(2), ME1(1), MMP1(1), NR1H3(4), PCK1(3), PPARA(2), PPARG(1), RXRA(1), RXRG(3), SCD(1), SCP2(1), SLC27A1(2), SLC27A5(3), SORBS1(1), UBC(7)	21391658	70	29	67	25	14	16	9	24	7	0	0.403	1.000	1.000
489	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(3), C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C3AR1(2), C4BPA(2), C4BPB(1), C5(4), C6(2), C7(4), C8A(1), C8B(2), CD46(2), CD55(1), CFD(1), CFH(7), CPB2(1), CR1(4), CR2(3), F13A1(2), F2(2), F5(7), F7(2), F8(12), F9(1), FGA(4), FGB(1), KLKB1(5), KNG1(1), MBL2(2), PLAT(1), PLAU(1), PLG(3), PROS1(1), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), VWF(5)	29570330	110	44	110	33	31	18	14	30	17	0	0.101	1.000	1.000
490	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), ARHGAP5(1), BCAR1(1), BIRC2(1), BRAF(3), CCND1(1), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), CRKL(1), DIAPH1(3), DOCK1(1), EGF(3), ELK1(3), ERBB2(1), FARP2(1), FLNA(8), FLNB(7), FLNC(7), FLT1(3), FN1(2), FYN(1), HGF(2), IBSP(1), IGF1R(3), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KDR(6), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), MET(6), MYL2(1), MYLK(3), MYLK2(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PARVA(1), PARVB(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PRKCA(3), PRKCG(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RAPGEF1(3), RELN(6), ROCK1(2), ROCK2(2), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TLN1(2), TLN2(4), TNC(3), TNN(7), TNR(4), TNXB(9), VAV1(4), VAV2(1), VAV3(5), VCL(1), VEGFA(2), VEGFB(1), VEGFC(2), VWF(5)	118921834	350	101	348	112	102	71	42	79	51	5	0.0132	1.000	1.000
491	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY7(2), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRB2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), AVPR1A(2), AVPR1B(1), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CCKBR(3), CHRM1(1), CHRM3(2), CHRM5(4), CHRNA7(1), CYSLTR1(1), CYSLTR2(1), EDNRB(1), ERBB2(1), ERBB3(2), ERBB4(4), GNA11(1), GNA14(1), GNAL(1), GNAS(3), GRIN2A(2), GRIN2C(3), GRIN2D(4), GRM1(4), GRM5(2), GRPR(2), HRH1(1), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), ITPR1(2), ITPR2(11), ITPR3(6), LTB4R2(1), MYLK(3), MYLK2(1), NOS1(2), NOS3(5), NTSR1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), PDE1A(1), PDE1B(2), PDE1C(5), PDGFRA(8), PHKA1(2), PHKA2(4), PHKG1(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), PPID(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PTGER3(1), PTGFR(5), RYR1(9), RYR2(11), RYR3(8), SLC25A5(1), SLC25A6(1), SLC8A2(3), SLC8A3(2), TACR2(1), TBXA2R(1), TNNC1(1), TRHR(2), TRPC1(1), VDAC2(1), VDAC3(2)	86971152	289	98	287	96	93	52	34	59	49	2	0.0485	1.000	1.000
492	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), CHAD(1), COL11A1(5), COL11A2(4), COL17A1(2), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), DSC1(2), DSC2(1), DSC3(4), DSG1(2), DSG2(1), DSG3(2), DSG4(1), FN1(2), GJA1(4), GJA10(1), GJA3(1), GJA4(1), GJA8(1), GJB2(1), GJB6(1), GJD4(1), IBSP(1), INA(1), ITGA6(3), ITGB4(2), KRT1(3), KRT12(1), KRT14(1), KRT15(1), KRT16(3), KRT17(2), KRT2(1), KRT20(2), KRT24(1), KRT25(1), KRT27(1), KRT28(2), KRT3(3), KRT31(1), KRT33A(4), KRT33B(2), KRT34(1), KRT35(3), KRT36(2), KRT37(1), KRT39(2), KRT5(4), KRT6B(2), KRT6C(3), KRT7(1), KRT71(2), KRT73(1), KRT75(2), KRT76(1), KRT77(1), KRT78(1), KRT8(3), KRT83(3), KRT84(1), KRT86(2), KRT9(1), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), LMNA(2), LMNB2(2), NES(3), PRPH(1), RELN(6), SPP1(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VIM(2), VWF(5)	81328014	256	90	254	87	92	59	22	54	27	2	0.0669	1.000	1.000
493	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	244	ACVR1B(2), ACVR1C(1), AKT1(1), ARRB1(2), ATF4(1), BDNF(1), BRAF(3), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1F(4), CACNA1G(5), CACNA1H(4), CACNA1I(3), CACNA1S(6), CACNA2D1(2), CACNA2D2(1), CACNA2D3(1), CACNA2D4(2), CACNB2(3), CACNB3(1), CACNB4(1), CACNG1(2), CACNG2(1), CACNG3(2), CACNG7(3), CACNG8(1), CRKL(1), DAXX(2), DDIT3(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(2), DUSP7(1), DUSP9(2), EGF(3), ELK1(3), FAS(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(2), FGFR4(3), FLNA(8), FLNB(7), FLNC(7), GNG12(1), IL1B(1), IL1R1(1), IL1R2(2), KRAS(1), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K8(2), MAP4K3(1), MAP4K4(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(4), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MRAS(1), NFATC2(4), NFATC4(3), NFKB1(1), NFKB2(1), NLK(1), NR4A1(1), NRAS(1), PAK1(2), PDGFA(1), PDGFRA(8), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(1), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKCA(3), PRKCG(1), PTPN5(1), PTPN7(1), PTPRR(3), RAC1(1), RAC2(1), RAF1(1), RAPGEF2(3), RASA1(4), RASA2(2), RASGRF1(2), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RRAS(1), SOS1(1), SOS2(4), SRF(2), STK3(2), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2)	90234307	279	90	278	107	85	52	34	59	45	4	0.319	1.000	1.000
494	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(3), ADORA3(2), ADRA1A(1), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CALCR(1), CCKBR(3), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CNR1(1), CNR2(3), CTSG(1), CYSLTR1(1), CYSLTR2(1), DRD3(1), DRD5(2), EDNRB(1), F2(2), FPR1(1), FSHR(2), GABBR1(2), GABRA1(7), GABRA3(1), GABRA4(4), GABRA5(1), GABRA6(4), GABRB1(4), GABRB2(2), GABRB3(2), GABRD(2), GABRE(3), GABRG1(5), GABRG2(2), GABRG3(1), GABRP(1), GABRQ(1), GABRR1(2), GALR1(1), GH1(1), GHR(2), GHRHR(2), GIPR(2), GLP2R(1), GLRA1(1), GLRB(2), GNRHR(2), GPR35(1), GPR50(2), GPR63(1), GPR83(2), GRIA1(4), GRIA2(2), GRIA3(5), GRIA4(2), GRID1(1), GRID2(3), GRIK1(3), GRIK2(1), GRIK3(1), GRIK4(4), GRIK5(2), GRIN2A(2), GRIN2B(4), GRIN2C(3), GRIN2D(4), GRIN3A(2), GRIN3B(1), GRM1(4), GRM2(3), GRM3(4), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(1), GRPR(2), HCRTR2(2), HRH1(1), HRH4(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LEPR(1), LTB4R(1), LTB4R2(1), MC3R(1), MC4R(3), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPBWR1(1), NPBWR2(1), NPY1R(3), NR3C1(2), NTSR1(1), OPRL1(1), OPRM1(1), P2RX1(2), P2RX2(1), P2RX3(1), P2RX4(2), P2RX7(1), P2RY1(1), P2RY13(1), P2RY2(3), P2RY4(1), P2RY6(2), P2RY8(2), PARD3(1), PPYR1(2), PRLR(1), PRSS1(1), PRSS3(1), PTGER3(1), PTGER4(1), PTGFR(5), PTH2R(1), RXFP1(2), RXFP2(1), SSTR2(1), SSTR3(2), SSTR4(5), TAAR5(1), TAAR6(1), TACR2(1), TBXA2R(1), TRHR(2), TSHR(4), UTS2R(1), VIPR1(1)	72397897	279	88	279	89	85	54	31	77	32	0	0.0112	1.000	1.000
495	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	200	ABI2(2), ACTN2(6), ACTN3(1), ACTN4(2), APC(2), ARAF(1), ARHGEF1(1), ARHGEF12(1), ARHGEF4(3), ARHGEF6(3), ARPC1B(1), ARPC3(1), BAIAP2(2), BCAR1(1), BRAF(3), CFL1(1), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CRKL(1), CSK(1), CYFIP2(5), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(1), EGF(3), EZR(1), F2(2), FGD3(1), FGF13(1), FGF16(1), FGF5(2), FGF6(1), FGF7(1), FGFR1(1), FGFR2(2), FGFR3(2), FGFR4(3), FN1(2), GIT1(1), GNG12(1), GSN(1), IQGAP1(8), IQGAP2(4), IQGAP3(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAD(1), ITGAE(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), KRAS(1), LIMK1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MRAS(1), MYH10(4), MYH14(4), MYL2(1), MYLK(3), MYLK2(1), NCKAP1(2), NCKAP1L(3), NRAS(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDGFA(1), PDGFRA(8), PFN3(1), PFN4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PPP1CB(1), PPP1R12A(1), PTK2(1), RAC1(1), RAC2(1), RAF1(1), RDX(5), ROCK1(2), ROCK2(2), RRAS(1), SCIN(2), SOS1(1), SOS2(4), SSH2(1), SSH3(1), TIAM1(3), TIAM2(4), VAV1(4), VAV2(1), VAV3(5), VCL(1), WAS(2), WASF1(1), WASL(1)	88166586	247	85	245	80	54	42	34	63	51	3	0.0959	1.000	1.000
496	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(2), ABLIM2(2), ABLIM3(1), ARHGEF12(1), CFL1(1), CXCR4(1), DCC(5), EFNA1(1), EFNA3(1), EFNA5(1), EFNB1(1), EFNB3(1), EPHA2(2), EPHA3(3), EPHA4(5), EPHA5(2), EPHA6(1), EPHA7(4), EPHA8(2), EPHB1(1), EPHB2(1), EPHB3(1), EPHB4(1), EPHB6(3), FES(2), FYN(1), GNAI1(1), ITGB1(2), KRAS(1), L1CAM(4), LIMK1(2), LRRC4C(4), MAPK1(1), MAPK3(1), MET(6), NCK1(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NGEF(3), NRAS(1), NRP1(3), NTN4(1), NTNG1(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PLXNA1(7), PLXNA2(4), PLXNA3(5), PLXNB1(4), PLXNB2(5), PLXNB3(3), PLXNC1(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC2(1), RASA1(4), RGS3(5), RHOD(1), RND1(1), ROBO1(3), ROBO2(5), ROBO3(2), ROCK1(2), ROCK2(2), SEMA3A(4), SEMA3B(1), SEMA3C(1), SEMA3D(2), SEMA3E(4), SEMA3F(2), SEMA4B(1), SEMA4D(2), SEMA4F(2), SEMA4G(1), SEMA6A(2), SEMA6B(3), SEMA6C(2), SEMA6D(2), SEMA7A(2), SLIT1(4), SLIT2(3), SLIT3(1), SRGAP1(2), SRGAP2(3), SRGAP3(1), UNC5A(1), UNC5B(1), UNC5C(1)	64538174	214	65	214	72	61	38	28	56	30	1	0.120	1.000	1.000
497	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(1), CD36(3), CD44(2), CHAD(1), COL11A1(5), COL11A2(4), COL1A1(2), COL1A2(7), COL2A1(4), COL3A1(2), COL4A1(1), COL4A2(2), COL4A4(4), COL4A6(5), COL5A1(2), COL5A2(2), COL5A3(1), COL6A1(2), COL6A3(10), COL6A6(3), DAG1(1), FN1(2), FNDC1(2), FNDC3A(3), FNDC5(1), GP5(1), GP9(1), HSPG2(8), IBSP(1), ITGA1(2), ITGA10(3), ITGA11(2), ITGA2(4), ITGA2B(1), ITGA4(2), ITGA5(1), ITGA6(3), ITGA7(2), ITGA8(3), ITGAV(2), ITGB1(2), ITGB3(2), ITGB4(2), ITGB6(4), ITGB7(4), ITGB8(1), LAMA1(7), LAMA2(4), LAMA3(7), LAMA4(1), LAMA5(9), LAMB1(2), LAMB2(1), LAMB4(4), LAMC1(3), LAMC2(3), LAMC3(1), RELN(6), SDC1(1), SDC3(1), SPP1(1), SV2A(2), SV2B(2), SV2C(1), THBS1(1), THBS2(4), THBS3(2), THBS4(3), TNC(3), TNN(7), TNR(4), TNXB(9), VWF(5)	73172025	217	65	217	64	68	54	24	47	22	2	0.00850	1.000	1.000
498	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(1), ACTN2(6), ACTN3(1), ACTN4(2), AKT1(1), AMOTL1(1), ASH1L(4), CASK(1), CDK4(1), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CRB3(2), CSNK2A1(2), CTNNA2(2), CTNNA3(1), CTTN(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), HCLS1(1), INADL(4), JAM2(3), JAM3(2), KRAS(1), LLGL1(3), LLGL2(1), MAGI1(2), MAGI2(4), MAGI3(5), MLLT4(4), MPDZ(6), MRAS(1), MYH1(5), MYH10(4), MYH11(2), MYH13(5), MYH14(4), MYH15(5), MYH2(9), MYH3(6), MYH6(2), MYH7(5), MYH7B(5), MYH8(7), MYL2(1), NRAS(1), OCLN(1), PARD3(1), PARD6A(1), PPM1J(2), PPP2CB(1), PPP2R2C(3), PPP2R3A(2), PPP2R4(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), RAB3B(1), RRAS(1), SPTAN1(2), SYMPK(2), TJAP1(1), TJP1(4), TJP2(1), TJP3(1), YES1(2)	61710360	179	64	179	67	60	29	25	43	20	2	0.333	1.000	1.000
499	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	248	ACVR1(3), ACVR1B(2), ACVR2A(1), AMHR2(1), CCL11(1), CCL20(1), CCL26(2), CCL27(1), CCL5(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CD40(1), CD40LG(2), CD70(1), CLCF1(1), CNTF(1), CNTFR(2), CRLF2(2), CSF1R(3), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CR1(1), CXCL9(1), CXCR4(1), EDA(1), EDAR(4), EGF(3), EPOR(1), FAS(1), FLT1(3), FLT3(2), FLT4(3), GDF5(1), GH1(1), GHR(2), HGF(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(1), IL17RA(1), IL18RAP(1), IL1B(1), IL1R1(1), IL1R2(2), IL1RAP(1), IL20RA(2), IL23A(1), IL23R(4), IL25(1), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), INHBA(1), INHBB(1), INHBE(1), KDR(6), KIT(3), KITLG(2), LEPR(1), LIFR(1), LTBR(2), MET(6), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(8), PRLR(1), RELT(2), TGFB2(2), TGFB3(1), TGFBR1(1), TGFBR2(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11A(2), TNFRSF12A(1), TNFRSF13B(1), TNFRSF14(1), TNFRSF17(1), TNFRSF19(1), TNFRSF1B(2), TNFRSF21(2), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(2), TNFSF14(1), TNFSF15(3), TNFSF8(1), TPO(3), VEGFA(2), VEGFB(1), VEGFC(2), XCL1(1)	56946760	184	61	184	69	47	42	30	37	28	0	0.254	1.000	1.000
500	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADRA1A(1), ADRA1B(2), ADRB2(1), ANXA6(2), ARRB1(2), ATP1B2(1), ATP2A2(3), ATP2A3(1), ATP2B1(1), ATP2B2(2), ATP2B3(6), CACNA1A(1), CACNA1B(7), CACNA1C(1), CACNA1D(5), CACNA1E(5), CACNA1S(6), CACNB3(1), CALR(2), CAMK2A(1), CAMK2D(1), CAMK2G(2), CAMK4(2), CASQ1(2), CASQ2(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), GJA1(4), GJA4(1), GJB2(1), GJB6(1), GNA11(1), GNAO1(2), GNB5(1), GNG12(1), GRK4(4), GRK5(4), ITPR1(2), ITPR2(11), ITPR3(6), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(1), PLCB3(3), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(1), RYR1(9), RYR2(11), RYR3(8), SLC8A3(2), YWHAH(1), YWHAQ(1)	61223447	187	59	186	64	64	32	20	42	27	2	0.127	1.000	1.000
501	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ADK(1), ADSL(3), ADSSL1(1), AK5(1), AK7(4), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), ENTPD5(1), ENTPD6(1), ENTPD8(1), GART(3), GMPR(1), GMPR2(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE10A(1), PDE11A(4), PDE1A(1), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE7A(1), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLA1(2), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1), PPAT(2), PRIM1(1), PRIM2(2), PRPS1L1(1), PRPS2(3), RRM1(3), XDH(7)	53337016	157	56	155	49	51	30	15	41	20	0	0.0553	1.000	1.000
502	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(1), CADM1(4), CD22(1), CD226(1), CD274(1), CD276(1), CD28(1), CD4(1), CD40(1), CD40LG(2), CDH1(3), CDH15(1), CDH2(2), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CNTN1(1), CNTNAP1(4), CNTNAP2(4), CTLA4(1), ESAM(1), F11R(1), GLG1(1), HLA-A(1), HLA-DMA(1), HLA-DMB(3), HLA-DPB1(1), HLA-DQA2(2), HLA-DRA(2), HLA-DRB5(3), HLA-E(1), HLA-F(1), ICAM1(2), ICAM2(1), ITGA4(2), ITGA6(3), ITGA8(3), ITGAL(1), ITGAM(1), ITGAV(2), ITGB1(2), ITGB2(1), ITGB7(4), ITGB8(1), JAM2(3), JAM3(2), L1CAM(4), MPZ(1), NCAM1(1), NEGR1(2), NEO1(5), NLGN1(2), NLGN2(2), NLGN3(2), NRCAM(3), NRXN1(5), NRXN3(2), OCLN(1), PDCD1LG2(1), PTPRC(4), PTPRF(3), PTPRM(4), PVR(2), PVRL1(1), SDC1(1), SDC3(1), SELE(4), SELP(2), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(1), VCAN(5)	48273981	154	55	153	55	43	37	13	39	22	0	0.157	1.000	1.000
503	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA2(2), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ARRB1(2), ATF4(1), ATF5(1), ATP2A2(3), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), GABPA(2), GABPB2(1), GBA2(1), GJA1(4), GNB5(1), GNG12(1), GRK4(4), GRK5(4), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IL1B(1), IL6(1), ITPR1(2), ITPR2(11), ITPR3(6), MIB1(1), MYL2(1), MYLK2(1), NFKB1(1), NOS1(2), NOS3(5), PDE4D(3), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(7), PRKAR1A(1), PRKCA(3), PRKCH(2), PRKCQ(1), RGS11(1), RGS14(1), RGS18(1), RGS19(1), RGS3(5), RGS6(1), RGS7(3), RGS9(1), RLN1(1), RYR1(9), RYR2(11), RYR3(8), TNXB(9), YWHAH(1), YWHAQ(1)	56502908	169	52	167	64	59	24	20	42	22	2	0.388	1.000	1.000
504	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA3(2), ADRA1A(1), ADRA1B(2), ADRB2(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCBP2(1), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CCR9(1), CHML(2), CHRM1(1), CHRM3(2), CHRM4(1), CHRM5(4), CMKLR1(1), CNR1(1), CNR2(3), CX3CR1(1), CXCR4(1), DRD3(1), DRD5(2), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GPR174(1), GPR35(1), GPR37(1), GPR4(1), GPR50(2), GPR6(1), GPR63(1), GPR77(1), GPR83(2), GPR85(2), GPR87(1), GRPR(2), HCRTR2(2), HRH1(1), HTR1A(1), HTR1B(1), HTR1D(1), HTR1F(2), HTR2A(1), HTR2B(2), HTR2C(1), HTR4(1), HTR5A(3), HTR7(1), LTB4R(1), MC3R(1), MC4R(3), MC5R(1), MLNR(1), MTNR1A(1), NMBR(3), NMUR1(3), NMUR2(2), NPY1R(3), NTSR1(1), OPN1SW(1), OPN3(1), OPRL1(1), OPRM1(1), OR10A5(2), OR11A1(1), OR1C1(3), OR1F1(1), OR1Q1(1), OR5V1(2), OR7C1(1), P2RY1(1), P2RY12(1), P2RY13(1), P2RY2(3), P2RY6(2), PPYR1(2), PTGER4(1), PTGFR(5), SSTR2(1), SSTR3(2), SSTR4(5), SUCNR1(1), TBXA2R(1), TRHR(2)	39696183	146	51	146	53	47	23	17	44	15	0	0.153	1.000	1.000
505	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CSNK1D(1), EGF(3), GJA1(4), GNA11(1), GNAI1(1), GNAS(3), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), HTR2A(1), HTR2B(2), HTR2C(1), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(3), NPR1(1), NPR2(2), NRAS(1), PDGFA(1), PDGFC(1), PDGFD(1), PDGFRA(8), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PRKACG(1), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), SOS1(1), SOS2(4), TJP1(4), TUBA1A(1), TUBA3C(4), TUBA3D(1), TUBB(1), TUBB3(3), TUBB6(2), TUBB8(1)	42341766	126	50	126	43	42	19	16	22	25	2	0.238	1.000	1.000
506	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), ATF4(1), CACNA1C(1), CACNA1D(5), CACNA1F(4), CACNA1S(6), CAMK2A(1), CAMK2D(1), CAMK2G(2), ELK1(3), GNA11(1), GNAS(3), GNRHR(2), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAP3K3(2), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK7(3), MAPK8(1), MAPK9(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLD1(5), PRKACG(1), PRKCA(3), RAF1(1), SOS1(1), SOS2(4)	40712421	124	49	124	35	46	18	16	21	21	2	0.0274	1.000	1.000
507	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	124	ARAF(1), BRAF(3), CD244(1), FAS(1), FCGR3A(1), FCGR3B(1), FYN(1), HLA-A(1), HLA-E(1), ICAM1(2), ICAM2(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), ITGAL(1), ITGB2(1), KIR2DL1(2), KLRC1(1), KLRC2(1), KRAS(1), LAT(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(3), NCR2(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NRAS(1), PAK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCA(3), PRKCG(1), PTPN11(6), RAC1(1), RAC2(1), RAF1(1), SHC1(1), SHC2(1), SHC4(1), SOS1(1), SOS2(4), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), ULBP3(2), VAV1(4), VAV2(1), VAV3(5), ZAP70(3)	35807585	118	48	114	40	32	15	17	29	23	2	0.271	1.000	1.000
508	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(1), BRAF(3), CACNA1A(1), GNA11(1), GNAI1(1), GNAO1(2), GNAS(3), GRIA1(4), GRIA2(2), GRIA3(5), GRID2(3), GRM1(4), GRM5(2), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IGF1R(3), ITPR1(2), ITPR2(11), ITPR3(6), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(2), NOS3(5), NPR1(1), NPR2(2), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(3), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PPP2CB(1), PPP2R2C(3), PRKCA(3), PRKCG(1), PRKG1(1), PRKG2(1), RAF1(1), RYR1(9)	36016225	115	46	115	34	28	18	19	25	23	2	0.115	1.000	1.000
509	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA2(2), ACTN2(6), ACTN3(1), ACTN4(2), DMD(6), FAM48A(1), MYBPC1(2), MYBPC2(3), MYH3(6), MYH6(2), MYH7(5), MYH8(7), MYL1(1), MYL2(1), MYOM1(1), NEB(16), TNNI1(1), TNNT1(1), TNNT3(1), TPM1(4), TPM2(1), TPM3(2), TPM4(1), TTN(66), VIM(2)	44367286	141	46	141	40	42	26	18	41	12	2	0.0547	1.000	1.000
510	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(3), AMY2B(2), ASCC3(2), ATP13A2(1), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), ENPP1(1), ENPP3(2), EP400(2), ERCC2(1), ERCC3(1), G6PC(3), G6PC2(1), GAA(5), GANC(3), GBE1(1), GCK(1), GPI(2), GUSB(2), GYS1(1), HK1(3), HK2(2), HK3(1), IFIH1(1), LYZL1(1), MGAM(4), MOV10L1(1), PYGB(1), PYGL(3), PYGM(1), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(3), SI(6), SKIV2L2(2), SMARCA2(1), SMARCA5(1), TREH(1), UGDH(1), UGP2(1), UGT1A1(6), UGT2A1(3), UGT2A3(3), UGT2B10(5), UGT2B11(2), UGT2B15(1), UGT2B28(2), UGT2B4(2), UGT2B7(1), UXS1(2)	40423287	115	45	114	36	32	20	19	33	11	0	0.199	1.000	1.000
511	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	70	CDS2(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(3), INPP5B(2), INPP5D(2), INPPL1(4), ITGB1BP3(1), ITPK1(2), ITPR1(2), ITPR2(11), ITPR3(6), OCRL(4), PI4KA(5), PI4KB(1), PIK3C2A(3), PIK3C2G(1), PIK3C3(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PIP4K2A(1), PIP4K2B(2), PIP4K2C(2), PIP5K1C(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCD3(2), PLCE1(6), PLCG1(6), PLCG2(7), PLCZ1(3), PRKCA(3), PRKCG(1), SYNJ1(4), SYNJ2(7)	39208482	123	45	122	35	39	23	15	29	16	1	0.0731	1.000	1.000
512	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	108	ACTN2(6), ACTN3(1), ACTN4(2), ARHGAP5(1), BCAR1(1), CDH5(2), CLDN1(1), CLDN14(1), CLDN16(1), CLDN19(2), CLDN2(1), CLDN22(1), CLDN7(1), CLDN8(1), CTNNA2(2), CTNNA3(1), CXCR4(1), CYBB(1), ESAM(1), EZR(1), F11R(1), GNAI1(1), ICAM1(2), ITGA4(2), ITGAL(1), ITGAM(1), ITGB1(2), ITGB2(1), ITK(1), JAM2(3), JAM3(2), MAPK12(2), MAPK13(1), MLLT4(4), MMP9(1), MYL2(1), NCF1(1), NCF2(3), NOX1(1), NOX3(1), OCLN(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLCG1(6), PLCG2(7), PRKCA(3), PRKCG(1), PTK2(1), PTPN11(6), RAC1(1), RAC2(1), RAPGEF3(1), RAPGEF4(2), RHOH(1), ROCK1(2), ROCK2(2), SIPA1(2), TXK(1), VAV1(4), VAV2(1), VAV3(5), VCAM1(1), VCL(1)	39359847	119	45	115	48	40	21	12	30	15	1	0.485	1.000	1.000
513	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(10), ACACB(5), AKT1(1), ARAF(1), BRAF(3), CBLB(1), CBLC(1), CRKL(1), ELK1(3), EXOC7(1), FASN(1), FBP1(1), FBP2(2), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(1), GCK(1), GYS1(1), INPP5D(2), INSR(3), IRS1(2), IRS2(1), IRS4(6), KRAS(1), LIPE(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(1), MAPK9(1), NRAS(1), PCK1(3), PDE3A(2), PFKL(2), PHKA1(2), PHKA2(4), PHKG1(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PKLR(1), PPP1CB(1), PPP1R3A(2), PPP1R3C(1), PRKAA1(3), PRKAA2(2), PRKACG(1), PRKAG1(1), PRKAG2(1), PRKAR1A(1), PRKCI(1), PTPRF(3), PYGB(1), PYGL(3), PYGM(1), RAF1(1), RAPGEF1(3), RPS6KB1(1), RPS6KB2(2), SHC1(1), SHC2(1), SHC4(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(1), SOS2(4), SREBF1(2), TSC1(2), TSC2(2)	51128813	132	45	130	53	35	24	12	41	17	3	0.614	1.000	1.000
514	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	143	APC(2), AXIN1(1), BTRC(1), CAMK2A(1), CAMK2D(1), CAMK2G(2), CCND1(1), CHD8(1), CREBBP(8), CSNK1A1(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CTBP1(3), CUL1(1), CXXC4(1), DAAM1(1), DKK1(1), DKK2(2), DKK4(2), DVL2(1), DVL3(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), LRP5(4), LRP6(5), MAPK10(1), MAPK8(1), MAPK9(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NKD2(1), NLK(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PORCN(4), PPP2CB(1), PPP2R2C(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(1), PRICKLE2(3), PRKACG(1), PRKCA(3), PRKCG(1), RAC1(1), RAC2(1), ROCK1(2), ROCK2(2), RUVBL1(1), SENP2(2), SFRP1(1), SFRP2(1), SFRP4(1), SIAH1(1), SMAD2(3), SMAD3(2), SOX17(2), TBL1XR1(1), TBL1Y(1), TCF7L2(2), VANGL1(1), VANGL2(1), WIF1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1)	52526677	143	44	143	41	46	25	14	38	19	1	0.0418	1.000	1.000
515	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	107	ABL1(4), ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), ATM(4), ATR(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(2), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC27(4), CDK2(1), CDK4(1), CDKN1B(1), CDKN2A(2), CDKN2C(1), CHEK1(3), CHEK2(6), CREBBP(8), CUL1(1), DBF4(4), E2F1(1), E2F3(1), EP300(3), ESPL1(5), FZR1(2), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), PKMYT1(1), PLK1(1), PRKDC(9), RB1(4), RBL1(2), RBL2(2), SKP2(2), SMAD2(3), SMAD3(2), SMC1A(1), SMC1B(4), TGFB2(2), TGFB3(1), WEE1(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	43721985	137	41	134	43	21	28	24	36	26	2	0.312	1.000	1.000
516	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	148	AKT1(1), CBLB(1), CBLC(1), CCND1(1), CISH(1), CLCF1(1), CNTF(1), CNTFR(2), CREBBP(8), CRLF2(2), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(3), EPOR(1), GH1(1), GHR(2), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IFNGR2(1), IFNK(1), IFNW1(1), IL12B(2), IL12RB1(1), IL12RB2(1), IL13RA1(1), IL15(2), IL20RA(2), IL23A(1), IL23R(4), IL26(1), IL2RB(1), IL3RA(2), IL5RA(1), IL6(1), IL6ST(2), IL9(1), IRF9(2), JAK2(3), JAK3(1), LEPR(1), LIFR(1), MPL(2), OSMR(3), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PIM1(2), PRLR(1), PTPN11(6), SOCS4(1), SOS1(1), SOS2(4), SPRED1(1), SPRED2(2), SPRY1(1), SPRY4(1), STAM2(1), STAT1(2), STAT3(1), STAT4(2), STAT5B(2), STAT6(3), TPO(3), TYK2(5)	46216473	128	39	127	46	31	19	19	45	13	1	0.494	1.000	1.000
517	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), AKAP11(1), AKAP12(1), AKAP3(1), AKAP4(4), AKAP5(2), AKAP6(8), AKAP7(1), AKAP8(2), AKAP9(5), ARHGEF1(1), GNA11(1), GNA14(1), GNAL(1), GNAO1(2), GNB5(1), GNG12(1), ITPR1(2), KCNJ3(1), KRAS(1), NRAS(1), PDE1A(1), PDE1B(2), PDE1C(5), PDE4A(1), PDE4C(1), PDE4D(3), PDE7A(1), PDE7B(2), PDE8A(4), PLCB3(3), PPP3CA(1), PPP3CC(1), PRKACG(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), RRAS(1)	38245125	91	38	91	45	28	14	8	21	18	2	0.889	1.000	1.000
518	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(3), B3GNT7(1), CHPF(1), CHST1(1), CHST11(1), CHST13(1), CHST3(2), CHST4(1), CHSY1(1), DAD1(1), DPAGT1(1), EXT1(3), EXT2(2), EXTL1(2), EXTL3(1), FUT8(3), GALNT1(1), GALNT12(2), GALNT14(2), GALNT2(2), GALNT4(2), GALNT5(2), GALNT6(2), GALNT8(1), GALNT9(2), GALNTL1(2), GALNTL4(2), GALNTL5(1), GANAB(2), GCNT4(2), HS6ST2(3), MAN1A1(2), MAN1A2(1), MAN1C1(1), MAN2A1(4), MGAT1(2), MGAT2(2), MGAT3(2), MGAT5(1), MGAT5B(2), NDST1(2), NDST2(2), NDST3(2), NDST4(1), OGT(6), RPN2(1), ST3GAL1(1), ST3GAL4(1), ST6GAL1(1), ST6GALNAC1(1), STT3B(1), WBSCR17(4), XYLT1(1), XYLT2(1)	35958403	103	38	103	33	31	19	12	27	14	0	0.271	1.000	1.000
519	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADCY9(3), CAMK2A(1), CAMK2D(1), CAMK2G(2), CREB1(1), CREB3L1(1), CREB3L2(1), CREBBP(8), DVL2(1), DVL3(1), EDNRB(1), EP300(3), FZD1(1), FZD10(1), FZD4(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), GNAI1(1), GNAO1(2), GNAS(3), KIT(3), KITLG(2), KRAS(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PRKACG(1), PRKCA(3), PRKCG(1), RAF1(1), TCF7L2(2), TYR(4), TYRP1(2), WNT11(4), WNT2(2), WNT2B(1), WNT3A(1), WNT5B(1), WNT7A(1), WNT8B(1), WNT9B(1)	35559005	95	38	95	33	35	9	7	26	16	2	0.272	1.000	1.000
520	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(1), ADCY1(1), ADCY2(3), ADCY3(2), ADCY4(4), ADCY5(2), ADCY7(2), ADK(1), ADSL(3), AK5(1), ALLC(2), AMPD1(2), AMPD2(3), AMPD3(1), ATP5B(1), ATP5G2(1), CANT1(3), ENPP1(1), ENPP3(2), ENTPD1(1), GART(3), GUCY1A2(1), GUCY1A3(1), GUCY2C(3), GUCY2F(2), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(2), NT5C(2), NT5E(1), NT5M(1), PAICS(1), PDE1A(1), PDE4A(1), PDE4C(1), PDE4D(3), PDE5A(1), PDE6B(3), PDE6C(6), PDE7B(2), PDE8A(4), PDE9A(1), PFAS(5), PKLR(1), POLB(1), POLD1(1), POLD2(2), POLE(7), POLG(1), POLL(1), POLQ(1), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), PPAT(2), PRPS1L1(1), PRPS2(3), RRM1(3)	41879607	118	38	118	48	43	25	11	27	12	0	0.499	1.000	1.000
521	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	81	ACVR1(3), ACVR1B(2), ACVRL1(3), AKT1(1), BUB1(3), CDS2(2), CLK1(2), CLK4(1), CSNK2A1(2), DGKB(2), DGKD(3), DGKG(1), DGKH(3), DGKQ(2), INPP4B(3), INPPL1(4), NEK3(1), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PIM2(1), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(7), PLK3(1), PRKACG(1), PRKAR1A(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), TGFBR1(1), VRK1(3)	36109167	96	37	95	38	28	17	11	23	14	3	0.654	1.000	1.000
522	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	90	AKT1(1), CARD11(1), CBLB(1), CBLC(1), CD28(1), CD3D(1), CD4(1), CD40LG(2), CDK4(1), CTLA4(1), FYN(1), ITK(1), KRAS(1), LAT(1), MAP3K14(1), MAP3K8(2), NCK1(1), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NRAS(1), PAK1(2), PAK3(3), PAK6(3), PAK7(2), PDK1(2), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLCG1(6), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(1), PTPRC(4), SOS1(1), SOS2(4), TEC(1), VAV1(4), VAV2(1), VAV3(5), ZAP70(3)	31914958	90	33	87	33	28	16	7	21	17	1	0.459	1.000	1.000
523	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(4), ATM(4), BUB1(3), BUB1B(1), BUB3(2), CCNA1(1), CCNB2(1), CCNB3(3), CCNE2(1), CCNH(2), CDAN1(3), CDC14A(2), CDC14B(2), CDC20(1), CDC25A(1), CDH1(3), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(6), DTX4(1), E2F1(1), E2F3(1), E2F5(1), EP300(3), ESPL1(5), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), MDM2(2), MPEG1(2), MPL(2), PLK1(1), PRKDC(9), PTPRA(4), RB1(4), RBL1(2), SKP2(2), TBC1D8(1), WEE1(1)	35241646	106	32	104	39	16	24	20	27	17	2	0.545	1.000	1.000
524	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	BRAF(3), CREB1(1), DAXX(2), ELK1(3), MAP2K2(1), MAP2K3(2), MAP2K5(1), MAP3K1(2), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K3(2), MAP3K4(4), MAP3K5(2), MAP3K8(2), MAP3K9(3), MAP4K3(1), MAP4K4(2), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK4(1), MAPK7(3), MAPK8(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(2), MAX(4), MEF2A(2), MEF2B(1), NFKB1(1), NFKBIA(1), PAK1(2), RAC1(1), RAF1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), SHC1(1), STAT1(2), TGFB2(2), TGFB3(1), TGFBR1(1), TRADD(1)	31017992	86	32	85	33	24	10	14	21	15	2	0.598	1.000	1.000
525	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(5), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ADIPOR1(2), ADIPOR2(3), AKT1(1), CAMKK1(1), CAMKK2(1), CD36(3), CPT1A(1), CPT1C(1), CPT2(1), G6PC(3), G6PC2(1), IRS1(2), IRS2(1), IRS4(6), JAK2(3), JAK3(1), LEPR(1), MAPK10(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(3), PPARA(2), PRKAA1(3), PRKAA2(2), PRKAG1(1), PRKAG2(1), PRKCQ(1), PTPN11(6), RELA(1), RXRA(1), RXRG(3), SLC2A1(1), SLC2A4(1), STAT3(1), TNFRSF1B(2), TRADD(1), TYK2(5)	27113275	87	29	85	36	23	18	4	28	13	1	0.663	1.000	1.000
526	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(3), ABCA12(3), ABCA13(10), ABCA2(3), ABCA3(3), ABCA4(3), ABCA5(2), ABCA6(5), ABCA7(4), ABCA8(3), ABCA9(2), ABCB1(3), ABCB11(1), ABCB4(4), ABCB5(3), ABCB7(2), ABCB8(1), ABCB9(1), ABCC1(4), ABCC10(7), ABCC11(3), ABCC12(4), ABCC3(5), ABCC4(2), ABCC5(3), ABCC6(1), ABCC8(4), ABCC9(3), ABCD1(2), ABCG1(1), ABCG4(2), ABCG5(3), ABCG8(3), CFTR(2)	38522644	105	28	105	41	28	18	15	30	12	2	0.507	1.000	1.000
527	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	62	APAF1(1), ATM(4), ATR(4), BAI1(2), BAX(1), CCNB2(1), CCNB3(3), CCND1(1), CCNE2(1), CCNG2(1), CDK2(1), CDK4(1), CDKN2A(2), CHEK1(3), CHEK2(6), CYCS(2), DDB2(2), EI24(2), FAS(1), GTSE1(4), IGFBP3(1), MDM2(2), MDM4(1), PPM1D(1), RFWD2(3), SERPINE1(1), SESN1(1), SESN3(1), SIAH1(1), STEAP3(1), THBS1(1), TSC2(2), ZMAT3(3)	20768456	62	27	59	26	13	9	13	18	9	0	0.662	1.000	1.000
528	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	41	CREBBP(8), CTBP1(3), DTX1(1), DTX2(1), DTX3L(1), DTX4(1), DVL2(1), DVL3(1), EP300(3), JAG1(2), LFNG(1), MAML1(1), MAML2(1), MAML3(3), MFNG(1), NCOR2(3), NCSTN(3), NOTCH2(10), NOTCH3(4), NOTCH4(8), NUMBL(2), RBPJ(2), RBPJL(1), SNW1(2)	20934075	64	27	64	29	19	10	5	16	13	1	0.826	1.000	1.000
529	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	96	AKT1(1), CCL5(1), CD40(1), CXCL9(1), IFNA21(2), IFNA5(1), IFNA7(1), IFNA8(1), IFNAR2(2), IFNB1(1), IKBKE(4), IL12B(2), IL1B(1), IL6(1), IRAK4(1), IRF7(2), LBP(1), MAP2K2(1), MAP2K3(2), MAP3K8(2), MAPK1(1), MAPK10(1), MAPK12(2), MAPK13(1), MAPK3(1), MAPK8(1), MAPK9(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), RAC1(1), RELA(1), RIPK1(1), SPP1(1), STAT1(2), TBK1(2), TICAM1(1), TLR1(1), TLR3(5), TLR6(2), TLR7(3), TLR9(1), TRAF3(1)	28075112	70	26	69	33	20	13	11	16	8	2	0.738	1.000	1.000
530	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(3), C3AR1(2), CCKBR(3), CCR10(1), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR4(1), EDNRB(1), FPR1(1), FSHR(2), GALR1(1), GNB2L1(1), GNRHR(2), GPR77(1), GRPR(2), MC3R(1), MC4R(3), MC5R(1), NMBR(3), NPY1R(3), NTSR1(1), OPRL1(1), OPRM1(1), PPYR1(2), SSTR2(1), SSTR3(2), SSTR4(5), TACR2(1), TRHR(2), TSHR(4)	17108011	60	26	60	27	19	10	10	18	3	0	0.569	1.000	1.000
531	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(1), BLNK(2), BTK(1), CARD11(1), CD22(1), CD81(1), CR2(3), IFITM1(1), INPP5D(2), KRAS(1), LILRB3(4), NFAT5(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), NRAS(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PLCG2(7), PPP3CA(1), PPP3CC(1), PPP3R2(1), RAC1(1), RAC2(1), RASGRP3(1), VAV1(4), VAV2(1), VAV3(5)	23060339	67	25	65	28	27	11	3	15	11	0	0.574	1.000	1.000
532	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA2(2), ACADL(1), ACADM(1), ACADS(1), ACADVL(1), ACAT2(1), ACOX1(1), ACOX3(3), ACSL1(3), ACSL3(2), ACSL4(1), ACSL6(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH5(1), ADH6(3), ADH7(1), ADHFE1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2)	16018658	52	22	52	21	14	8	3	14	13	0	0.652	1.000	1.000
533	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), AOX1(3), CAT(2), CYP1A2(2), CYP1B1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), HSD17B4(2), KMO(2), LCMT1(2), LCMT2(1), LNX1(3), METTL2B(3), METTL6(1), NFX1(1), OGDHL(2), PRMT2(2), PRMT5(1), PRMT6(1), TDO2(1), TPH1(2), TPH2(1), WARS2(2)	19815859	59	22	59	25	22	10	4	13	10	0	0.613	1.000	1.000
534	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(2), ACAT2(1), ACMSD(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), AOX1(3), CAT(2), CYP1A2(2), CYP2B6(1), CYP2C19(5), CYP2C8(1), CYP3A7(1), CYP4B1(1), CYP4F8(1), CYP51A1(1), DDC(1), ECHS1(2), EHHADH(1), GCDH(1), KMO(2), TDO2(1), TPH1(2), WARS2(2)	17991212	48	22	48	21	18	9	3	9	9	0	0.705	1.000	1.000
535	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH4A1(2), ARG2(1), ASL(2), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), GLUD1(3), GOT1(2), NOS1(2), NOS3(5), OAT(1), ODC1(2), P4HA1(1), RARS(2), SMS(1)	14460858	46	20	46	22	17	10	3	7	9	0	0.771	1.000	1.000
536	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	22	INPP4B(3), INPPL1(4), OCRL(4), PIK3C2A(3), PIK3C2G(1), PIK3CB(1), PIK3CG(4), PLCB1(2), PLCB2(1), PLCB3(3), PLCB4(1), PLCD1(1), PLCG1(6), PLCG2(7)	13924721	41	20	40	14	11	8	5	12	5	0	0.523	1.000	1.000
537	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	28	ELK1(3), GNAS(3), IGF1R(3), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), PDGFRA(8), PTPRR(3), RAF1(1), RPS6KA1(2), SHC1(1), SOS1(1), STAT3(1)	9929939	32	19	32	14	5	5	4	7	10	1	0.810	1.000	1.000
538	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(4), ATR(4), BRCA1(1), CDC25A(1), CDC34(1), CHEK1(3), CHEK2(6), EP300(3), MDM2(2), MYT1(3), PRKDC(9), RPS6KA1(2), WEE1(1), YWHAH(1), YWHAQ(1)	13351759	42	19	40	17	5	6	7	14	9	1	0.826	1.000	1.000
539	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), AMDHD1(2), ASPA(1), CNDP1(2), DDC(1), FTCD(1), HAL(1), HARS(1), HARS2(1), HDC(2), LCMT1(2), LCMT2(1), METTL2B(3), METTL6(1), PRMT2(2), PRMT5(1), PRMT6(1), PRPS2(3)	12966290	42	18	42	18	19	8	3	9	3	0	0.499	1.000	1.000
540	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(6), FAU(1), IL6ST(2), MRPL19(2), RPL10(3), RPL13A(1), RPL15(1), RPL18A(1), RPL29(1), RPL32(1), RPL36(1), RPL5(1), RPL6(1), RPL7(2), RPL7A(1), RPS11(1), RPS12(1), RPS18(1), RPS3(1), RPS4X(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), RPSA(2), SLC36A2(1), TBC1D10C(1), UBC(7)	17094562	51	18	49	17	13	8	5	18	7	0	0.603	1.000	1.000
541	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	32	CRKL(1), DOCK1(1), ELK1(3), HGF(2), ITGA1(2), ITGB1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(1), MET(6), PAK1(2), PTK2(1), PTPN11(6), RAF1(1), RASA1(4), SOS1(1), STAT3(1)	12892347	37	17	36	15	9	4	4	10	9	1	0.630	1.000	1.000
542	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	37	AKT1(1), BCR(1), BLNK(2), BTK(1), CSK(1), DAG1(1), EPHB2(1), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CD(1), PLCG2(7), PPP1R13B(1), RAF1(1), SERPINA4(1), SHC1(1), SOS1(1), SOS2(4), VAV1(4)	15971701	39	17	39	16	16	5	3	9	6	0	0.546	1.000	1.000
543	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), ARHGEF11(1), DLG4(3), LPA(5), MAP3K1(2), MAP3K5(2), MAPK8(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PDK1(2), PHKA2(4), PI3(1), PIK3CB(1), PLD1(5), PLD3(1), PTK2(1), RDX(5), ROCK1(2), ROCK2(2), SERPINA4(1), SRF(2), TBXA2R(1)	16007579	47	17	47	17	14	8	6	12	6	1	0.519	1.000	1.000
544	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(2), AGXT(2), AGXT2(1), ALAS1(1), ATP6V0C(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PLCB2(1), PLCG1(6), PLCG2(7), SARDH(2), SHMT1(1)	13758495	34	16	33	17	13	10	2	4	5	0	0.682	1.000	1.000
545	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(2), ADC(2), ALDH18A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), ARG2(1), ASL(2), ASS1(1), CPS1(4), ODC1(2), SMS(1), SRM(1)	9640696	31	16	31	12	11	4	3	4	9	0	0.585	1.000	1.000
546	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(1), ACAT2(1), AKR1B10(2), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ALDH7A1(2), DOT1L(2), ECHS1(2), EHHADH(1), EHMT1(4), EHMT2(2), GCDH(1), HSD17B4(2), NSD1(2), OGDHL(2), PIPOX(1), PLOD1(2), PLOD2(1), PLOD3(1), SETD1A(1), SETD7(3), SETDB1(1), SHMT1(1), SUV39H1(1), TMLHE(1)	18990407	49	16	49	22	21	6	2	8	12	0	0.676	1.000	1.000
547	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(2), ARG2(1), ASL(2), ASS1(1), CKM(1), CKMT1A(1), CKMT2(1), CPS1(4), EPRS(2), GLUD1(3), GLUD2(1), GOT1(2), LAP3(1), NOS1(2), NOS3(5), OAT(1), P4HA1(1), PARS2(1), RARS(2), RARS2(4)	11747414	38	16	38	16	11	9	2	9	7	0	0.687	1.000	1.000
548	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(2), ALDH1A3(3), ALDH3A1(5), DDC(1), EPX(2), ESCO2(2), GOT1(2), HPD(1), LPO(5), MPO(2), PNPLA3(1), SH3GLB1(3), TAT(1), TPO(3)	11182153	33	16	33	14	15	8	3	4	3	0	0.506	1.000	1.000
549	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	77	AIFM1(2), AKT1(1), APAF1(1), ATM(4), BAX(1), BIRC2(1), CASP10(1), CFLAR(1), CSF2RB(1), CYCS(2), DFFA(1), FAS(1), IL1B(1), IL1R1(1), IL1RAP(1), IL3RA(2), IRAK2(1), IRAK3(4), IRAK4(1), MAP3K14(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACG(1), PRKAR1A(1), RELA(1), RIPK1(1), TNFRSF10C(1), TNFRSF10D(1), TRADD(1)	25782880	50	16	50	27	11	8	6	15	10	0	0.969	1.000	1.000
550	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(2), AKT1(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(1), PDK1(2), PHKA2(4), PIK3CB(1), PITX2(3), PLD1(5), PLD3(1)	14644016	43	16	43	18	14	7	8	10	3	1	0.576	1.000	1.000
551	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CAMK1G(1), ELK1(3), FPR1(1), MAP2K2(1), MAP2K3(2), MAP3K1(2), MAPK1(1), MAPK3(1), NCF1(1), NCF2(3), NFATC1(1), NFATC2(4), NFATC3(2), NFATC4(3), NFKB1(1), NFKBIA(1), PAK1(2), PIK3C2G(1), PLCB1(2), PPP3CA(1), PPP3CC(1), RAC1(1), RAF1(1), RELA(1)	12501259	38	15	38	18	15	4	1	8	9	1	0.753	1.000	1.000
552	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(2), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), ASPA(1), CNDP1(2), DDC(1), HAL(1), HARS(1), HDC(2), PRPS2(3)	7996227	26	15	26	13	14	5	2	3	2	0	0.676	1.000	1.000
553	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), GUSB(2), HEXA(1), HGSNAT(2), HPSE(2), HPSE2(1), HYAL1(1), IDS(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NAGLU(2), NEU1(1), NEU2(2), NEU3(1), SPAM1(1)	11256997	30	15	30	16	8	3	5	8	6	0	0.931	1.000	1.000
554	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(2), ALDH1A3(3), ALDH3A1(5), DDC(1), EPX(2), GOT1(2), HPD(1), LPO(5), MPO(2), PRDX1(1), TAT(1), TPO(3)	7190390	28	15	28	13	14	6	3	2	3	0	0.506	1.000	1.000
555	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	23	EIF2B4(1), FLT1(3), FLT4(3), KDR(6), NOS3(5), PLCG1(6), PRKCA(3), PTK2(1), SHC1(1)	9883713	29	15	28	16	9	5	6	4	4	1	0.873	1.000	1.000
556	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(2), AXIN1(1), CCND1(1), CSNK1E(1), DVL2(1), DVL3(1), FZD1(1), FZD10(1), FZD5(1), FZD6(1), FZD7(1), FZD8(1), FZD9(1), MAPK10(1), MAPK9(1), PAFAH1B1(4), PLAU(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(1), RAC1(1), SFRP4(1), WNT11(4), WNT2(2), WNT2B(1), WNT5B(1), WNT7A(1)	19610292	40	15	40	18	14	3	7	9	5	2	0.659	1.000	1.000
557	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(2), ACADL(1), ACADM(1), ALDH1A1(1), ALDH1A3(3), ALDH1B1(4), ALDH3A1(5), CNDP1(2), DPYD(3), DPYS(1), ECHS1(2), EHHADH(1), GAD1(2), GAD2(1), MLYCD(3), SMS(1)	9502426	34	14	34	14	13	7	2	7	5	0	0.518	1.000	1.000
558	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPP(2), ASCC3(2), ATP13A2(1), DDX23(2), DDX4(3), DDX41(1), DDX47(1), DDX52(1), DDX54(2), DDX55(1), DDX56(2), DHX58(1), EP400(2), ERCC2(1), ERCC3(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(2), RAD54L(3), RUVBL2(1), SETX(3), SKIV2L2(2), SMARCA2(1), SMARCA5(1), SPR(1)	20484502	42	14	42	18	14	9	4	9	6	0	0.745	1.000	1.000
559	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(1), BRAF(3), CAB39(1), EIF4B(1), MAPK1(1), MAPK3(1), PIK3CB(1), PIK3CD(1), PIK3CG(4), PIK3R2(1), PIK3R5(1), PRKAA1(3), PRKAA2(2), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), RPS6KB2(2), TSC1(2), TSC2(2), ULK2(5), VEGFA(2), VEGFB(1), VEGFC(2)	16127161	44	14	44	16	14	5	8	12	4	1	0.438	1.000	1.000
560	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	41	DAXX(2), EGF(3), ETS1(3), HOXA7(1), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK3(1), MAPK8(1), NFKB1(1), NFKBIA(1), PRKCA(3), PRKCG(1), PRKCH(2), PRKCQ(1), RAF1(1), RELA(1), RIPK1(1), TNFRSF1B(2)	15176423	34	14	34	15	11	5	4	4	7	3	0.523	1.000	1.000
561	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), ANKRD6(2), APC(2), AXIN1(1), CSNK1A1(2), DACT1(2), DKK1(1), DKK2(2), DKK4(2), LRP1(15), NKD2(1), PTPRA(4), SENP2(2), SFRP1(1), WIF1(2)	13170762	40	14	40	15	12	8	3	13	4	0	0.616	1.000	1.000
562	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC10(1), ANAPC2(2), ANAPC5(2), ANAPC7(1), BTRC(1), CDC16(2), CDC20(1), CDC23(2), CDC27(4), CUL1(1), CUL2(3), CUL3(1), FBXW7(1), FZR1(2), SKP2(2), SMURF1(1), SMURF2(1), UBE2D3(2), UBE2D4(2), WWP1(3)	13127225	35	13	33	18	6	5	5	11	8	0	0.967	1.000	1.000
563	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	30	ACTR2(1), ACTR3(1), AKT1(1), ANGPTL2(1), DAG1(1), ITPR1(2), ITPR2(11), ITPR3(6), MAPK1(1), MAPK3(1), PAK1(2), PDE3A(2), PI3(1), PIK3C2G(1), PIK3CD(1), RPS4X(2), SGCB(1)	14676295	36	13	36	17	7	3	8	11	6	1	0.883	1.000	1.000
564	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CREB1(1), EEF2K(1), EIF4E(1), ELK1(3), IL1R1(1), MAP2K3(2), MAP3K4(4), MAP3K5(2), MAPK1(1), MAPK12(2), MAPK13(1), MAPKAPK2(1), MAPKAPK5(2), MYEF2(2), NFKB1(1), NR2C2(1), SRF(2)	10870869	29	13	29	14	8	3	7	7	4	0	0.820	1.000	1.000
565	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(3), APOA1(1), APOA4(2), APOE(1), CETP(1), CYP7A1(1), LIPC(1), LPL(2), LRP1(15), SCARB1(1), SOAT1(1)	8950619	29	13	29	12	10	6	1	9	3	0	0.663	1.000	1.000
566	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	24	BRCA1(1), CCND1(1), CREBBP(8), EP300(3), ERCC3(1), ESR1(1), GRIP1(1), GTF2E1(3), GTF2F1(2), HDAC3(1), HDAC4(2), HDAC5(1), HDAC6(3), NCOR2(3), NRIP1(1), PELP1(1), POLR2A(3)	14757029	36	12	36	22	11	5	2	13	5	0	0.969	1.000	1.000
567	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1), MBL2(2)	6947273	29	12	29	11	8	3	4	8	6	0	0.568	1.000	1.000
568	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(3), CALCR(1), ELTD1(1), EMR1(2), EMR2(2), GHRHR(2), GIPR(2), GLP2R(1), GPR64(2), LPHN1(1), LPHN2(5), LPHN3(3), VIPR1(1)	8723239	26	12	26	12	5	5	6	10	0	0	0.807	1.000	1.000
569	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(2), ANXA2(2), ANXA3(1), ANXA6(2), EDNRB(1), HSD11B1(1), PLA2G4A(4), PTGER4(1), PTGFR(5), PTGS1(2), PTGS2(2), SCGB1A1(1)	6744468	24	12	24	10	7	3	3	8	3	0	0.732	1.000	1.000
570	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(1), BAX(1), CASP1(1), CASP10(1), CASP4(1), CD40(1), CD40LG(2), CRADD(1), CYCS(2), DAXX(2), DFFA(1), FAS(1), IKBKE(4), NFKB1(1), NFKBIA(1), NGFR(1), NR3C1(2), PTPN13(1), RIPK1(1), TFG(1), TNFRSF1B(2), TRADD(1), TRAF3(1)	14177378	31	11	31	16	11	5	1	6	8	0	0.839	1.000	1.000
571	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	21	BCAR1(1), CXCR4(1), GNAI1(1), MAPK1(1), MAPK3(1), NFKB1(1), PIK3C2G(1), PLCG1(6), PRKCA(3), PTK2(1), RAF1(1), RELA(1)	7788084	19	11	18	14	5	2	3	2	5	2	0.974	1.000	1.000
572	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA1(1), FUCA2(1), GLB1(1), HEXA(1), LCT(5), MAN2B1(1), MAN2B2(2), MAN2C1(1), NEU1(1), NEU2(2), NEU3(1)	6653788	18	11	18	13	5	2	2	5	4	0	0.983	1.000	1.000
573	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(2), AXIN1(1), CREBBP(8), EP300(3), FZD1(1), LDB1(2), PITX2(3), TRRAP(7)	10839859	27	11	27	12	9	4	1	11	2	0	0.737	1.000	1.000
574	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	AKT1(1), BTK(1), CDKN2A(2), IARS(1), INPP5D(2), PDK1(2), PPP1R13B(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), RPS6KB1(1), SHC1(1), SOS1(1), SOS2(4), TEC(1), YWHAH(1), YWHAQ(1), YWHAZ(1)	10769652	27	11	27	10	5	3	3	12	4	0	0.725	1.000	1.000
575	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	ELK1(3), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), PPARA(2), RELA(1), TLR10(4), TLR3(5), TLR6(2), TLR7(3), TLR9(1)	11930811	29	11	28	15	8	6	5	7	3	0	0.838	1.000	1.000
576	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(1), BAX(1), BCL2L11(1), BIRC2(1), CASP1(1), CASP10(1), CASP4(1), CYCS(2), DFFA(1), FAS(1), HELLS(2), IRF1(4), IRF2(1), IRF4(1), IRF6(1), IRF7(2), MAP3K1(2), MAPK10(1), MDM2(2), NFKB1(1), NFKBIA(1), NFKBIE(1), PLEKHG5(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1B(2), TNFRSF21(2), TRADD(1), TRAF3(1)	18413436	40	10	40	16	16	6	2	7	9	0	0.574	1.000	1.000
577	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1)	5709916	27	10	27	10	8	3	3	8	5	0	0.535	1.000	1.000
578	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(1), C1R(2), C1S(2), C3(9), C5(4), C6(2), C7(4), C8A(1), C8B(2)	6788833	29	10	29	14	8	5	3	8	5	0	0.755	1.000	1.000
579	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDK2(1), CDT1(1), DIAPH2(1), GMNN(1), MCM10(3), MCM3(2), MCM4(3), MCM5(1), MCM6(1), MCM7(3), POLD1(1), POLD2(2), POLD3(2), POLE(7), PRIM1(1), RFC4(2), RPA1(2), UBC(7)	16543469	41	10	39	18	7	4	5	17	8	0	0.837	1.000	1.000
580	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(2), GABBR1(2), GPRC5D(1), GRM1(4), GRM2(3), GRM3(4), GRM4(2), GRM5(2), GRM7(2), GRM8(1)	6869392	23	10	23	12	7	4	1	7	4	0	0.878	1.000	1.000
581	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLB(1), POLD1(1), POLD2(2), POLD3(2), POLE(7), POLG(1), POLH(1), POLI(4), POLK(1), POLL(1), POLM(2), POLQ(1), PRIM1(1), PRIM2(2), REV1(2), REV3L(3)	13197584	34	10	34	13	6	5	3	12	8	0	0.827	1.000	1.000
582	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(1), GTF2E1(3), GTF2H1(1), POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3B(5), POLR3D(1), TAF6(1), TAF9(2)	11458992	28	10	27	23	9	5	1	9	4	0	0.995	1.000	1.000
583	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(1), IRS1(2), IRS2(1), JAK3(1), MAPK1(1), MAPK3(1), PDK1(2), PIK3CD(1), PPP1R13B(1), RAF1(1), SHC1(1), SOS1(1), SOS2(4), STAT6(3)	10671979	21	10	21	10	4	3	2	8	3	1	0.789	1.000	1.000
584	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(4), ATM(4), BRCA1(1), CHEK1(3), CHEK2(6), MAPK8(1), MDM2(2), MRE11A(2), NFKB1(1), NFKBIA(1), RAD50(2), RBBP8(2), RELA(1)	9467283	30	9	28	13	6	7	6	7	4	0	0.743	1.000	1.000
585	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	28	ANPEP(2), G6PD(2), GCLC(1), GGT1(4), GPX1(2), GPX4(1), GSTA4(1), GSTZ1(2)	5371817	15	9	14	10	5	3	3	2	2	0	0.925	1.000	1.000
586	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	34	ANPEP(2), G6PD(2), GCLC(1), GGT1(4), GPX1(2), GPX4(1), GSTA4(1), GSTA5(3), GSTZ1(2), OPLAH(2)	6636942	20	9	19	11	7	5	3	3	2	0	0.802	1.000	1.000
587	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(4), POLR1B(2), POLR2A(3), POLR2B(1), POLR2C(1), POLR2G(1), POLR3A(5), POLR3B(5), POLR3GL(1)	7677525	23	9	22	11	7	3	2	8	3	0	0.748	1.000	1.000
588	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	IFNB1(1), IL1B(1), IL1R1(1), IL1RAP(1), IL6(1), IRAK2(1), IRAK3(4), MAP2K3(2), MAP3K1(2), MAP3K14(1), MAPK8(1), NFKB1(1), NFKBIA(1), RELA(1), TGFB2(2), TGFB3(1)	9681245	22	9	22	10	6	4	4	5	3	0	0.720	1.000	1.000
589	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(1), AP2M1(1), ARF1(1), BTK(1), EEA1(2), GRASP(1), PFKL(2), PLCG1(6), RAC1(1), RPS6KB1(1), VAV2(1)	8128976	19	9	18	10	6	6	1	3	3	0	0.771	1.000	1.000
590	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	CBS(3), CTH(1), DNMT1(3), DNMT3A(5), DNMT3B(3), MARS(4), MARS2(1), MTFMT(1), MTR(2), SRM(1), TAT(1)	6785366	25	8	25	11	6	5	1	10	1	2	0.650	1.000	1.000
591	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	23	CAPNS1(1), CAPNS2(1), EGF(3), ITGA1(2), ITGB1(2), MAPK1(1), MAPK3(1), MYL2(1), MYLK(3), PRKACG(1), PRKAR1A(1), PTK2(1), TLN1(2)	9813644	20	8	20	12	6	0	4	5	4	1	0.943	1.000	1.000
592	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR4(1), CCR7(1), CD28(1), CD4(1), CXCR4(1), IFNGR2(1), IL12B(2), IL12RB1(1), IL12RB2(1), TGFB2(2), TGFB3(1)	6531957	13	8	13	10	4	2	3	3	1	0	0.946	1.000	1.000
593	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CREBBP(8), EP300(3), IL1B(1), MAP2K3(2), MAP3K14(1), NFKB1(1), NFKBIA(1), NR3C1(2), RELA(1), TGFBR1(1), TGFBR2(2)	9703149	23	8	23	12	5	3	2	9	4	0	0.898	1.000	1.000
594	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2E1(3), GTF2F1(2), HDAC3(1), NCOA1(1), NCOA3(1), NCOR2(3), POLR2A(3), RXRA(1)	8149316	16	8	16	14	3	4	0	6	3	0	0.987	1.000	1.000
595	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(2), AGXT(2), AGXT2(1), AKR1B10(2), ALAS1(1), CBS(3), CHKB(1), CTH(1), GARS(2), GCAT(1), GLDC(2), PHGDH(2), PIPOX(1), SARDH(2), SARS2(2), SHMT1(1), TARS2(1)	13965240	27	7	27	15	6	9	3	3	6	0	0.785	1.000	1.000
596	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(2), LPO(5), MPO(2), TPO(3)	2732106	12	7	12	5	6	5	0	1	0	0	0.401	1.000	1.000
597	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	IL1R1(1), MAP3K1(2), MAP3K14(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFAIP3(1), TNFRSF1B(2), TRADD(1)	7952070	12	7	12	12	6	0	1	1	4	0	0.993	1.000	1.000
598	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CREBBP(8), EP300(3), HDAC3(1), NFKB1(1), NFKBIA(1), RELA(1), RIPK1(1), TNFRSF1B(2), TRADD(1)	7305473	19	7	19	11	6	1	0	7	5	0	0.939	1.000	1.000
599	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(3), CREB1(1), DUSP4(1), DUSP9(2), EEF2K(1), EIF4E(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), NFKB1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA3(2), SHC1(1), SOS1(1), SOS2(4), TRAF3(1)	9642812	28	7	28	12	8	2	5	9	3	1	0.664	1.000	1.000
600	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	17	CSF1R(3), E2F1(1), ETS1(3), ETV3(1), HDAC5(1), NCOR2(3), RBL1(2), RBL2(2), SIN3A(1), SIN3B(1)	8164624	18	6	18	10	5	4	1	6	2	0	0.842	1.000	1.000
601	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	24	AKT1(1), APC(2), AXIN1(1), CCND1(1), FZD1(1), GJA1(4), GNAI1(1), LBP(1), NFKB1(1), RELA(1)	8806736	14	5	14	10	4	3	1	4	2	0	0.959	1.000	1.000
602	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(3), FADS2(2), FASN(1), SCD(1)	4680768	8	5	8	11	1	1	0	4	2	0	0.998	1.000	1.000
603	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(1), FTCD(1), GART(3), MTFMT(1), MTHFD1(2), MTHFD1L(1), MTHFR(6), MTHFS(1), MTR(2), SHMT1(1)	6190459	19	4	19	10	5	6	2	4	1	1	0.747	1.000	1.000
604	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(2), CES1(1)	1976473	3	3	3	3	1	1	1	0	0	0	0.904	1.000	1.000
605	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(2)	3771087	4	3	4	4	1	1	1	1	0	0	0.954	1.000	1.000
606	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(1), FUT2(2)	1995071	3	2	3	3	1	0	1	1	0	0	0.969	1.000	1.000
607	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR2(2), IFNB1(1), MAPK8(1), NFKB1(1), RELA(1), TNFRSF11A(2)	3621228	8	2	8	7	1	1	1	5	0	0	0.970	1.000	1.000
608	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2)	2059797	2	2	2	3	1	0	1	0	0	0	0.979	1.000	1.000
609	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(3), FYN(1), THBS1(1)	2417804	5	2	5	4	2	2	1	0	0	0	0.840	1.000	1.000
610	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPNS1(1), CAPNS2(1), CSNK1A1(2), CSNK1D(1)	3026565	6	1	6	5	1	0	3	2	0	0	0.951	1.000	1.000
611	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(1)	1988165	1	1	1	2	0	0	1	0	0	0	0.971	1.000	1.000
612	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), SULT2A1(1), SUOX(1)	2000721	3	1	3	3	0	1	0	2	0	0	0.959	1.000	1.000
613	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1		236839	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
614	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		166633	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
615	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		499787	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
616	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3		560372	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
