Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Glypican 2 network	177.0	710.0	4.0	-0.203	-0.128	1000.0	-1000.0	-0.029	-1000.0
Angiopoietin receptor Tie2-mediated signaling	134.0	11798.0	88.0	-0.601	0.056	1000.0	-1000.0	-0.103	-1000.0
FOXM1 transcription factor network	125.0	6406.0	51.0	-0.568	0.01	1000.0	-1000.0	-0.182	-1000.0
Aurora B signaling	117.0	7889.0	67.0	-0.415	0.01	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by the Hedgehog family	93.0	4875.0	52.0	-0.369	0.176	1000.0	-1000.0	-0.065	-1000.0
Aurora C signaling	71.0	501.0	7.0	-0.266	0.005	1000.0	-1000.0	-0.036	-1000.0
Endothelins	71.0	6876.0	96.0	-0.306	0.02	1000.0	-1000.0	-0.067	-1000.0
PLK1 signaling events	66.0	5628.0	85.0	-0.3	0.06	1000.0	-1000.0	-0.04	-1000.0
HIF-1-alpha transcription factor network	63.0	4835.0	76.0	-0.487	0.016	1000.0	-1000.0	-0.166	-1000.0
Visual signal transduction: Cones	57.0	2170.0	38.0	-0.165	0.01	1000.0	-1000.0	-0.058	-1000.0
Signaling mediated by p38-alpha and p38-beta	54.0	2393.0	44.0	-0.119	0.01	1000.0	-1000.0	-0.048	-1000.0
IL4-mediated signaling events	53.0	4860.0	91.0	-0.781	0.513	1000.0	-1000.0	-0.172	-1000.0
Signaling events regulated by Ret tyrosine kinase	52.0	4303.0	82.0	-0.16	0.01	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	47.0	3811.0	81.0	-0.352	0.027	1000.0	-1000.0	-0.079	-1000.0
amb2 Integrin signaling	47.0	3877.0	82.0	-0.466	0.01	1000.0	-1000.0	-0.07	-1000.0
Fc-epsilon receptor I signaling in mast cells	45.0	4431.0	97.0	-0.149	0.028	1000.0	-1000.0	-0.077	-1000.0
Osteopontin-mediated events	44.0	1675.0	38.0	-0.366	0.011	1000.0	-1000.0	-0.09	-1000.0
TCGA08_retinoblastoma	44.0	354.0	8.0	-0.155	0.05	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	41.0	288.0	7.0	-0.107	0.054	1000.0	-1000.0	-0.013	-1000.0
FOXA2 and FOXA3 transcription factor networks	40.0	1847.0	46.0	-0.494	0.016	1000.0	-1000.0	-0.1	-1000.0
Visual signal transduction: Rods	40.0	2098.0	52.0	-0.153	0.01	1000.0	-1000.0	-0.067	-1000.0
Arf6 signaling events	36.0	2239.0	62.0	-0.188	0.011	1000.0	-1000.0	-0.053	-1000.0
Glucocorticoid receptor regulatory network	36.0	4210.0	114.0	-0.404	0.247	1000.0	-1000.0	-0.074	-1000.0
LPA4-mediated signaling events	34.0	416.0	12.0	-0.119	0.012	1000.0	-1000.0	-0.022	-1000.0
Canonical Wnt signaling pathway	34.0	1739.0	51.0	-0.344	0.149	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	32.0	3437.0	105.0	-0.091	0.028	1000.0	-1000.0	-0.065	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	32.0	1665.0	52.0	-0.252	0.043	1000.0	-1000.0	-0.056	-1000.0
p75(NTR)-mediated signaling	31.0	3954.0	125.0	-0.297	0.02	1000.0	-1000.0	-0.086	-1000.0
Glypican 1 network	31.0	1492.0	48.0	-0.117	0.019	1000.0	-1000.0	-0.051	-1000.0
Integrins in angiogenesis	30.0	2595.0	84.0	-0.369	0.024	1000.0	-1000.0	-0.072	-1000.0
Effects of Botulinum toxin	30.0	801.0	26.0	-0.09	0.01	1000.0	-1000.0	-0.057	-1000.0
Syndecan-1-mediated signaling events	29.0	1000.0	34.0	-0.34	0.01	1000.0	-1000.0	-0.052	-1000.0
Ephrin B reverse signaling	29.0	1410.0	48.0	-0.093	0.055	1000.0	-1000.0	-0.056	-1000.0
EGFR-dependent Endothelin signaling events	29.0	616.0	21.0	-0.091	0.01	1000.0	-1000.0	-0.055	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	29.0	3507.0	120.0	-0.253	0.199	1000.0	-1000.0	-0.066	-1000.0
Aurora A signaling	26.0	1582.0	60.0	-0.295	0.015	1000.0	-1000.0	-0.052	-1000.0
IL23-mediated signaling events	26.0	1584.0	60.0	-0.276	0.016	1000.0	-1000.0	-0.167	-1000.0
Presenilin action in Notch and Wnt signaling	25.0	1548.0	61.0	-0.345	0.02	1000.0	-1000.0	-0.062	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	25.0	1752.0	68.0	-0.137	0.03	1000.0	-1000.0	-0.126	-1000.0
IL6-mediated signaling events	24.0	1836.0	75.0	-0.327	0.042	1000.0	-1000.0	-0.095	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	23.0	786.0	33.0	-0.149	0.025	1000.0	-1000.0	-0.058	-1000.0
PDGFR-alpha signaling pathway	21.0	958.0	44.0	-0.312	0.027	1000.0	-1000.0	-0.059	-1000.0
Wnt signaling	21.0	148.0	7.0	-0.061	0.009	1000.0	-1000.0	-0.023	-1000.0
Class IB PI3K non-lipid kinase events	21.0	63.0	3.0	-0.013	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	19.0	672.0	34.0	-0.038	0.01	1000.0	-1000.0	-0.052	-1000.0
ErbB4 signaling events	19.0	1377.0	69.0	-0.191	0.205	1000.0	-1000.0	-0.085	-1000.0
Syndecan-3-mediated signaling events	19.0	680.0	35.0	-0.198	0.01	1000.0	-1000.0	-0.052	-1000.0
Nongenotropic Androgen signaling	19.0	998.0	52.0	-0.059	0.01	1000.0	-1000.0	-0.054	-1000.0
Regulation of Androgen receptor activity	19.0	1358.0	70.0	-0.255	0.026	1000.0	-1000.0	-0.063	-1000.0
PLK2 and PLK4 events	18.0	54.0	3.0	-0.019	-0.004	1000.0	-1000.0	-0.014	-1000.0
HIF-2-alpha transcription factor network	18.0	791.0	43.0	-0.124	0.049	1000.0	-1000.0	-0.093	-1000.0
Coregulation of Androgen receptor activity	16.0	1241.0	76.0	-0.149	0.018	1000.0	-1000.0	-0.046	-1000.0
Syndecan-2-mediated signaling events	16.0	1137.0	69.0	-0.093	0.032	1000.0	-1000.0	-0.053	-1000.0
Reelin signaling pathway	16.0	922.0	56.0	-0.096	0.01	1000.0	-1000.0	-0.07	-1000.0
Syndecan-4-mediated signaling events	16.0	1078.0	67.0	-0.171	0.015	1000.0	-1000.0	-0.085	-1000.0
Noncanonical Wnt signaling pathway	15.0	392.0	26.0	-0.061	0.01	1000.0	-1000.0	-0.067	-1000.0
Nectin adhesion pathway	15.0	978.0	63.0	-0.042	0.013	1000.0	-1000.0	-0.059	-1000.0
IL12-mediated signaling events	13.0	1194.0	87.0	-0.097	0.038	1000.0	-1000.0	-0.124	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	13.0	1018.0	78.0	-0.038	0.038	1000.0	-1000.0	-0.078	-1000.0
Caspase cascade in apoptosis	12.0	939.0	74.0	-0.041	0.031	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by PTP1B	12.0	984.0	76.0	-0.091	0.017	1000.0	-1000.0	-0.069	-1000.0
Signaling events mediated by HDAC Class III	12.0	512.0	40.0	-0.117	0.018	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	12.0	456.0	36.0	-0.066	0.011	1000.0	-1000.0	-0.051	-1000.0
FAS signaling pathway (CD95)	12.0	598.0	47.0	-0.242	0.012	1000.0	-1000.0	-0.043	-1000.0
EPHB forward signaling	12.0	1093.0	85.0	-0.066	0.05	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	12.0	1579.0	125.0	-0.312	0.034	1000.0	-1000.0	-0.08	-1000.0
LPA receptor mediated events	12.0	1297.0	102.0	-0.119	0.03	1000.0	-1000.0	-0.074	-1000.0
BCR signaling pathway	12.0	1204.0	99.0	-0.126	0.027	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by PRL	12.0	410.0	34.0	-0.184	0.021	1000.0	-1000.0	-0.039	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	11.0	612.0	54.0	-0.136	0.021	1000.0	-1000.0	-0.083	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	973.0	85.0	-0.041	0.032	1000.0	-1000.0	-0.069	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1030.0	93.0	-0.073	0.042	1000.0	-1000.0	-0.077	-1000.0
BARD1 signaling events	10.0	622.0	57.0	-0.184	0.03	1000.0	-1000.0	-0.062	-1000.0
Ephrin A  reverse signaling	10.0	72.0	7.0	-0.01	0.008	1000.0	-1000.0	-0.026	-1000.0
IL1-mediated signaling events	10.0	645.0	62.0	-0.141	0.049	1000.0	-1000.0	-0.084	-1000.0
S1P5 pathway	10.0	186.0	17.0	-0.035	0.03	1000.0	-1000.0	-0.043	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	324.0	31.0	-0.103	0.012	1000.0	-1000.0	-0.09	-1000.0
Regulation of p38-alpha and p38-beta	9.0	496.0	54.0	-0.071	0.019	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by STAT5	9.0	201.0	22.0	-0.123	0.055	1000.0	-1000.0	-0.047	-1000.0
Plasma membrane estrogen receptor signaling	9.0	797.0	86.0	-0.035	0.03	1000.0	-1000.0	-0.068	-1000.0
S1P4 pathway	9.0	244.0	25.0	-0.035	0.01	1000.0	-1000.0	-0.045	-1000.0
ErbB2/ErbB3 signaling events	8.0	584.0	65.0	-0.094	0.019	1000.0	-1000.0	-0.06	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	137.0	17.0	-0.014	0.021	1000.0	-1000.0	-0.04	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1082.0	136.0	-0.106	0.05	1000.0	-1000.0	-0.067	-1000.0
IL27-mediated signaling events	7.0	358.0	51.0	-0.107	0.011	1000.0	-1000.0	-0.068	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	187.0	28.0	-0.035	0.02	1000.0	-1000.0	-0.049	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	94.0	15.0	-0.0	0.022	1000.0	-1000.0	-0.028	-1000.0
Arf6 trafficking events	6.0	458.0	71.0	-0.082	0.034	1000.0	-1000.0	-0.068	-1000.0
Regulation of Telomerase	6.0	679.0	102.0	-0.093	0.03	1000.0	-1000.0	-0.1	-1000.0
Insulin Pathway	6.0	473.0	74.0	-0.151	0.03	1000.0	-1000.0	-0.075	-1000.0
VEGFR1 specific signals	6.0	379.0	56.0	-0.312	0.041	1000.0	-1000.0	-0.064	-1000.0
p38 MAPK signaling pathway	6.0	272.0	44.0	-0.081	0.026	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by HDAC Class II	5.0	395.0	75.0	-0.047	0.027	1000.0	-1000.0	-0.058	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	88.0	17.0	-0.013	0.031	1000.0	-1000.0	-0.057	-1000.0
Cellular roles of Anthrax toxin	5.0	222.0	39.0	-0.046	0.015	1000.0	-1000.0	-0.028	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	371.0	65.0	-0.171	0.054	1000.0	-1000.0	-0.057	-1000.0
Ceramide signaling pathway	5.0	401.0	76.0	-0.091	0.036	1000.0	-1000.0	-0.049	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	417.0	83.0	-0.068	0.04	1000.0	-1000.0	-0.072	-1000.0
Retinoic acid receptors-mediated signaling	5.0	336.0	58.0	-0.166	0.032	1000.0	-1000.0	-0.066	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	371.0	74.0	-0.114	0.06	1000.0	-1000.0	-0.074	-1000.0
IFN-gamma pathway	4.0	295.0	68.0	-0.081	0.047	1000.0	-1000.0	-0.086	-1000.0
Signaling events mediated by HDAC Class I	4.0	423.0	104.0	-0.047	0.043	1000.0	-1000.0	-0.064	-1000.0
FoxO family signaling	4.0	317.0	64.0	-0.127	0.055	1000.0	-1000.0	-0.075	-1000.0
IL2 signaling events mediated by PI3K	4.0	254.0	58.0	-0.148	0.066	1000.0	-1000.0	-0.079	-1000.0
Class I PI3K signaling events	4.0	344.0	73.0	-0.071	0.024	1000.0	-1000.0	-0.058	-1000.0
Circadian rhythm pathway	3.0	79.0	22.0	-0.03	0.033	1000.0	-1000.0	-0.049	-1000.0
Arf6 downstream pathway	3.0	164.0	43.0	-0.041	0.026	1000.0	-1000.0	-0.036	-1000.0
TCGA08_rtk_signaling	3.0	91.0	26.0	-0.022	0.037	1000.0	-1000.0	-0.019	-1000.0
IGF1 pathway	3.0	212.0	57.0	-0.037	0.04	1000.0	-1000.0	-0.076	-1000.0
S1P3 pathway	3.0	158.0	42.0	-0.034	0.023	1000.0	-1000.0	-0.049	-1000.0
TRAIL signaling pathway	2.0	124.0	48.0	-0.009	0.039	1000.0	-1000.0	-0.062	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	116.0	45.0	-0.013	0.061	1000.0	-1000.0	-0.079	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	182.0	76.0	-0.043	0.05	1000.0	-1000.0	-0.068	-1000.0
Rapid glucocorticoid signaling	2.0	59.0	20.0	-0.007	0.01	1000.0	-1000.0	-0.031	-1000.0
PDGFR-beta signaling pathway	2.0	219.0	97.0	-0.037	0.048	1000.0	-1000.0	-0.073	-1000.0
Canonical NF-kappaB pathway	1.0	44.0	39.0	-0.014	0.066	1000.0	-1000.0	-0.072	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.002	0.009	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	62.0	37.0	-0.005	0.037	1000.0	-1000.0	-0.046	-1000.0
ceramide signaling pathway	1.0	54.0	49.0	-0.013	0.039	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling events	1.0	8.0	5.0	-0.002	0.01	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	-0.003	0.036	1000.0	-1000.0	-0.063	-1000.0
EPO signaling pathway	0.0	50.0	55.0	-0.005	0.058	1000.0	-1000.0	-0.085	-1000.0
Insulin-mediated glucose transport	0.0	24.0	32.0	-0.004	0.035	1000.0	-1000.0	-0.055	-1000.0
mTOR signaling pathway	0.0	14.0	53.0	-0.001	0.026	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	25.0	68.0	-0.034	0.046	1000.0	-1000.0	-0.058	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.003	0.018	1000.0	-1000.0	-0.056	-1000.0
Atypical NF-kappaB pathway	0.0	21.0	31.0	-0.002	0.038	1000.0	-1000.0	-0.048	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	9.0	27.0	-0.001	0.023	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling in keratinocytes	0.0	28.0	43.0	-0.007	0.037	1000.0	-1000.0	-0.057	-1000.0
Arf1 pathway	0.0	20.0	54.0	-0.006	0.024	1000.0	-1000.0	-0.044	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.01	1000.0	-1000.0	-0.052	-1000.0
Total	2787	160870	7203	-18.5624959383	-995.223630866	131000	-131000	-8.32157033414	-131000