rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ARPC2(1), CDC42(1), PAK1(2), PDGFRA(8), PIK3CA(1), PIK3R1(1) 1058136 14 9 10 2 2 1 1 3 7 0 0.537 0.00857 1.000 2 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(1), CR1(3), CR2(4), FCGR2B(1), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 1305486 15 9 14 1 2 3 1 3 5 1 0.0742 0.00918 1.000 3 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 1 LIPT1(2) 64145 2 2 1 0 0 0 0 0 2 0 1.000 0.0201 1.000 4 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(3), IL6(2), TGFB1(1), TGFB2(2) 724148 9 5 8 1 1 2 4 0 2 0 0.279 0.0761 1.000 5 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 3 RANBP1(1), RANBP2(9) 623372 10 5 9 1 0 2 1 2 4 1 0.473 0.0859 1.000 6 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 ATM(6), CDC25A(2), CDC25C(2), MYT1(9), YWHAH(1) 1098181 20 9 16 5 2 3 2 3 10 0 0.725 0.0964 1.000 7 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 HLA-A(3), ICAM1(1), ITGAL(2), ITGB2(1), PRF1(3) 721204 10 6 8 1 1 1 1 2 5 0 0.391 0.0987 1.000 8 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(1), LTB4R(3), P2RY1(2), P2RY2(1), P2RY6(1) 514396 9 5 8 1 4 1 2 0 2 0 0.186 0.136 1.000 9 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(2), AGTR2(1), CMA1(1), COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), REN(4) 2187412 28 12 25 1 4 4 9 1 9 1 0.0299 0.138 1.000 10 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FSHB(1), FSHR(1), GNAS(6), XPO1(1) 837792 12 4 11 1 6 2 3 1 0 0 0.144 0.164 1.000 11 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD2(2), CD4(2), CD58(2), IL6(2) 506073 8 3 8 1 1 0 2 3 2 0 0.363 0.167 1.000 12 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 IL2RA(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TOB1(2) 885002 12 7 10 2 5 1 0 2 4 0 0.401 0.177 1.000 13 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(6), CDC25A(2), CDC25C(2), CDK4(2), MYT1(9), RB1(1), YWHAH(1) 1355171 23 9 19 5 3 3 4 3 10 0 0.623 0.190 1.000 14 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 FH(1), IDH2(3), OGDH(5), SDHA(3), SUCLA2(1) 805527 13 5 11 1 3 1 2 2 5 0 0.170 0.195 1.000 15 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IL12B(1) 256199 3 3 3 2 0 1 0 0 2 0 0.990 0.200 1.000 16 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(2), ST3GAL5(2), ST6GALNAC4(2), ST8SIA1(2) 485087 9 4 8 2 3 2 1 0 3 0 0.363 0.227 1.000 17 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 61729 3 1 3 1 2 0 0 0 1 0 0.718 0.246 1.000 18 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(4), DPYS(4), GAD1(5), GAD2(4), HADHA(1), HIBCH(2), UPB1(2) 2328770 30 11 29 5 9 5 6 3 6 1 0.0733 0.282 1.000 19 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC3B(1), APOBEC3F(1), APOBEC4(2) 626256 6 4 5 1 2 2 0 0 2 0 0.460 0.292 1.000 20 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT1(1), B3GALT2(1), FUT2(1) 620616 4 3 4 1 3 0 0 1 0 0 0.561 0.309 1.000 21 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CD4(2), IL1B(1), IL6(2) 394512 5 2 5 1 0 0 2 1 2 0 0.642 0.310 1.000 22 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 5 ARNTL(1), CRY1(1), CSNK1E(1), PER1(2) 600083 5 3 5 0 2 0 0 1 2 0 0.182 0.313 1.000 23 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), HRAS(1), KLK2(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(3) 1340175 13 6 13 1 3 3 1 2 4 0 0.147 0.321 1.000 24 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(1), ITGAL(2), ITGAM(1), ITGB2(1) 903677 8 4 7 1 1 1 1 2 3 0 0.336 0.339 1.000 25 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 4 CHRNA1(3) 227787 3 2 3 0 3 0 0 0 0 0 0.346 0.361 1.000 26 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), FARS2(2), GOT1(2) 706983 5 3 4 1 0 0 3 2 0 0 0.685 0.370 1.000 27 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), PC(2) 2251813 31 9 31 6 6 6 11 4 3 1 0.108 0.382 1.000 28 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(1), ITGAL(2), ITGAM(1), ITGB2(1), SELP(3) 1377510 11 5 10 1 2 2 1 2 4 0 0.128 0.394 1.000 29 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(1), IL6(2), LPL(2) 455143 7 2 7 0 1 2 2 0 2 0 0.105 0.396 1.000 30 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(2), CDC25C(2), CSK(1), SRC(1) 792964 6 5 4 1 1 1 0 0 4 0 0.686 0.402 1.000 31 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(1), GOT1(2) 747034 5 3 4 1 1 0 3 1 0 0 0.649 0.404 1.000 32 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 11 CSF1R(3), EGF(2), EGFR(2), MET(4), PDGFRA(8), SH3GLB1(1), SRC(1) 1516819 21 7 17 3 4 4 3 3 7 0 0.178 0.408 1.000 33 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(1), ITGAL(2), ITGB2(1) 1041413 7 4 6 1 1 0 1 2 3 0 0.473 0.414 1.000 34 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 25 CCL3(1), CCR1(1), CCR4(2), CCR7(1), CD4(2), CXCR4(3), IFNGR1(2), IL12B(1), TGFB1(1), TGFB2(2) 1472847 16 6 15 4 4 3 2 3 4 0 0.403 0.420 1.000 35 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 5 MAX(2), SP1(1) 457976 3 3 3 0 0 0 1 0 2 0 0.850 0.434 1.000 36 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CDK5(1), CDK5R1(1), LIMK1(1), MAP3K1(3), MYLK(8), NCF2(1), PAK1(2), PDGFRA(8), PIK3CA(1), PIK3R1(1), RALBP1(2), TRIO(6), VAV1(4), WASF1(1) 3012660 41 11 36 9 9 6 6 6 12 2 0.305 0.442 1.000 37 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 10 CAPN1(1), CAPNS1(3), CDK5(1), CDK5R1(1), CSNK1D(1), GSK3B(1), MAPT(1) 683234 9 4 9 1 3 3 0 0 3 0 0.171 0.447 1.000 38 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(2), SRP54(1), SRP68(4), SRP72(2), SRPR(2) 642793 11 3 11 1 3 4 3 0 1 0 0.167 0.465 1.000 39 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(1), IL6(2), IL7(1) 532430 6 2 6 1 0 1 2 2 1 0 0.508 0.466 1.000 40 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATM(6), ATR(5), CDC25C(2), CHEK2(1), YWHAH(1) 1209420 15 6 14 6 1 2 5 2 5 0 0.932 0.470 1.000 41 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD1(5), GAD2(4) 499548 11 5 11 5 3 2 3 1 1 1 0.731 0.471 1.000 42 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(3), MTHFD2(1) 1094018 10 6 8 0 1 2 0 0 7 0 0.187 0.475 1.000 43 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 592478 9 5 9 2 1 2 3 2 1 0 0.415 0.482 1.000 44 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNGR1(2), JAK1(2), JAK2(2), STAT1(1) 644179 7 4 6 2 0 0 2 1 4 0 0.838 0.483 1.000 45 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(1), GHR(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SHC1(1), SOD1(1) 1144953 13 5 13 3 3 2 1 2 5 0 0.468 0.486 1.000 46 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GLS(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), PPAT(2), QARS(1) 2860782 35 10 35 8 7 5 13 4 4 2 0.229 0.492 1.000 47 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(4), GLS(1), GOT1(2) 670218 7 2 7 0 1 1 2 2 0 1 0.168 0.492 1.000 48 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(2), JAK2(2), PTPRU(6), STAT1(1) 982768 13 6 12 4 4 1 3 1 4 0 0.660 0.496 1.000 49 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(3), ARHGAP5(3), CASP1(2), CASP10(1), CASP8(2), PRF1(3) 1105130 14 6 13 4 2 3 0 2 7 0 0.691 0.498 1.000 50 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(2), CHAT(3), GAD1(5), GAD2(4), SLC18A3(1), TPH1(2) 1267040 17 7 17 6 6 1 6 1 2 1 0.516 0.506 1.000 51 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), GRHPR(1), HAO1(1), HAO2(1), MDH2(1), MTHFD1L(3), MTHFD2(1) 1146428 10 6 8 1 1 2 0 0 7 0 0.429 0.513 1.000 52 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(5), TPH1(2) 530093 7 3 7 3 1 0 2 1 2 1 0.768 0.513 1.000 53 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), BAD(1), HRAS(1), IGF1R(4), PIK3CA(1), PIK3R1(1), SHC1(1), SOS1(3), YWHAH(1) 1411983 15 6 15 4 3 3 0 3 6 0 0.609 0.523 1.000 54 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(3) 171962 3 1 3 0 0 0 2 0 1 0 0.420 0.525 1.000 55 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(1), RAB27A(1), RAB3A(1), RAB9A(2) 365555 7 2 7 1 3 3 0 1 0 0 0.188 0.526 1.000 56 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(2), AGTR2(1), NOS3(6), REN(4) 869950 15 7 12 2 3 0 5 0 7 0 0.462 0.530 1.000 57 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(4), ALPL(1), ALPP(4), ALPPL2(2), DHFR(1), FPGS(3), GCH1(1), GGH(1) 582636 17 5 16 3 6 5 0 1 5 0 0.0715 0.532 1.000 58 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), NR3C1(2), RETN(2) 495952 7 3 6 1 1 0 2 1 3 0 0.530 0.539 1.000 59 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ6(1) 355588 1 1 1 0 0 0 0 0 1 0 0.830 0.539 1.000 60 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(5), OGDHL(1), PC(2), PCK1(2), PCK2(3), SDHA(3), SUCLA2(1), SUCLG1(1) 2563823 30 9 27 4 9 3 4 4 9 1 0.0768 0.543 1.000 61 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(2), CFLAR(2) 331209 4 2 4 3 0 0 1 1 2 0 0.908 0.549 1.000 62 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(2), APAF1(3), FAS(1), FASLG(1), MAPKAPK2(1), MAPKAPK3(1) 847407 9 4 9 1 2 4 0 1 2 0 0.176 0.550 1.000 63 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(5), C6(6), C7(3), ICAM1(1), IL6(2), ITGAL(2), ITGB2(1), SELP(3) 2122250 23 10 20 7 3 6 5 1 8 0 0.587 0.551 1.000 64 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(5), C6(6), C7(3), C8A(3), C9(1) 1075527 18 7 16 5 2 5 4 3 4 0 0.618 0.564 1.000 65 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(2) 140735 3 1 3 0 1 1 0 1 0 0 0.348 0.565 1.000 66 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1) 520093 9 2 9 1 0 2 1 3 3 0 0.297 0.570 1.000 67 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(2) 191010 2 1 2 1 0 0 0 1 1 0 0.765 0.578 1.000 68 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(2), ACADL(1), ACADSB(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), DPYD(4), DPYS(4), GAD1(5), GAD2(4), HADHA(1), UPB1(2) 2500933 31 9 31 5 9 7 6 4 4 1 0.0383 0.583 1.000 69 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(4), MMP2(2), MMP9(2), RECK(3) 651583 12 4 11 4 5 1 2 0 4 0 0.571 0.583 1.000 70 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(6), ABAT(1), ADSL(1), ADSS(1), AGXT2(1), ASNS(3), CAD(4), CRAT(1), DARS(1), DDO(1), DLAT(3), GAD1(5), GAD2(4), GOT1(2), GPT(1), GPT2(2), NARS2(1), PC(2), PDHA1(1) 3274451 42 12 41 9 8 8 13 4 8 1 0.141 0.586 1.000 71 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(3), AKT1(2), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(3), ITGB3(1), PDGFRA(8), PIK3CA(1), PIK3R1(1), PLCB1(1), PTK2(3), SPHK1(1), SRC(1) 2248809 28 8 25 1 5 7 2 5 9 0 0.00338 0.587 1.000 72 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(1), FGA(3), FGB(4), FGG(1), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1) 1148137 15 4 14 3 2 4 5 2 2 0 0.330 0.596 1.000 73 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25A(2), CDK7(1) 519353 3 3 2 1 0 0 0 0 3 0 0.898 0.598 1.000 74 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(2) 203972 2 1 2 1 0 0 0 1 1 0 0.905 0.603 1.000 75 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), KEAP1(1), MAFF(1), MAPK8(1), NFE2L2(1) 779413 5 3 5 1 1 0 0 2 2 0 0.548 0.605 1.000 76 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(1) 159529 1 1 1 0 0 0 0 1 0 0 0.795 0.613 1.000 77 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(1), JUND(1) 331008 2 2 2 0 0 0 0 1 1 0 0.809 0.616 1.000 78 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(1), CAMP(2), CREB1(1), SNX13(4), SRC(1), TERF2IP(1) 967945 13 4 13 2 2 1 2 4 4 0 0.350 0.619 1.000 79 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 15 CD86(1), IFNGR1(2), IL12B(1), IL2RA(1) 888228 5 3 5 0 1 1 0 1 2 0 0.261 0.620 1.000 80 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 6 CDK5(1), CDK5R1(1), RELN(8) 1096439 10 5 9 6 3 1 1 1 4 0 0.951 0.631 1.000 81 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 PARK2(3), SNCAIP(3) 550460 6 2 6 1 1 0 3 1 1 0 0.435 0.636 1.000 82 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 14 B3GALT4(1), GLB1(1), HEXB(1), LCT(3), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1) 1278745 18 6 17 5 7 3 1 0 7 0 0.225 0.648 1.000 83 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 10 APEX1(1), CREBBP(2), PRF1(3), SET(1) 880670 7 5 6 1 0 1 1 1 4 0 0.679 0.649 1.000 84 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), HBXIP(1), HRAS(1), SHC1(1), SOS1(3), SRC(1) 760205 8 4 8 1 1 2 1 1 3 0 0.445 0.655 1.000 85 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(1), B3GNT7(1), B4GALT2(1), CHST2(1), CHST4(1), CHST6(3), ST3GAL1(2) 1091684 10 4 10 0 3 1 3 1 2 0 0.0394 0.659 1.000 86 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 HLA-A(3), KLRC1(1), KLRC2(2), PAK1(2), PIK3CA(1), PIK3R1(1), PTPN6(4), SYK(2), VAV1(4) 1599610 20 6 19 4 5 2 3 5 4 1 0.280 0.660 1.000 87 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 821285 9 5 9 3 3 1 2 2 1 0 0.649 0.660 1.000 88 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(2), CYP11B1(2), CYP11B2(1), CYP17A1(1), HSD11B1(1), HSD3B1(2) 821285 9 5 9 3 3 1 2 2 1 0 0.649 0.660 1.000 89 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(3), GLS(1), OAT(2), PRODH(1) 488144 7 2 7 1 2 1 2 0 2 0 0.353 0.663 1.000 90 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 5 CD4(2) 244859 2 1 2 1 0 0 0 1 1 0 0.906 0.664 1.000 91 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDC25A(2), CDC25C(2), CDK7(1), XPO1(1) 749706 6 4 4 1 1 0 0 0 5 0 0.737 0.665 1.000 92 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(2), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 890730 8 3 7 0 2 1 0 2 3 0 0.107 0.673 1.000 93 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP7(1), TOP2A(1), TOP2B(1) 757778 3 2 3 0 0 2 0 1 0 0 0.361 0.674 1.000 94 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), JAK1(2), PTPRU(6), STAT1(1), STAT2(1), TYK2(1) 1078205 13 5 12 4 6 1 3 1 2 0 0.545 0.685 1.000 95 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(3), FURIN(2), NOTCH1(7), PSEN1(1) 848285 13 4 12 5 5 5 1 0 2 0 0.362 0.688 1.000 96 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(2), CHRNA1(3), FLT1(2), FLT4(8), KDR(1), NOS3(6), PDE2A(1), PDE3A(7), PDE3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(8), SLC7A1(1), TNNI1(1) 3545570 51 13 50 9 18 9 11 3 9 1 0.0125 0.692 1.000 97 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB10(1), PSMB4(1), PSMB5(1) 748779 8 5 8 5 1 0 2 1 4 0 0.970 0.694 1.000 98 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD2(2), CD4(2), ICAM1(1), ITGAL(2), ITGB2(1), PTPRC(2) 935835 10 3 9 1 2 1 0 3 4 0 0.259 0.694 1.000 99 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), HRAS(1), MAPK7(4), MEF2A(1), MEF2D(1), NTRK1(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RPS6KA1(1), SHC1(1) 1647659 17 6 17 2 3 5 2 1 6 0 0.155 0.697 1.000 100 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(8), ATM(6), BRCA1(3), CHEK2(1), MAPK8(1), MDM2(1), MRE11A(2), NFKBIA(2), RBBP8(2), RELA(1) 2410605 27 8 26 3 4 5 8 2 8 0 0.123 0.699 1.000 101 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCND1(1), CCNE1(1), CDK4(2), HRAS(1), NFKBIA(2), PAK1(2), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1) 1750102 15 7 14 6 2 2 4 2 5 0 0.919 0.703 1.000 102 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(1), PIK3R1(1), PLCB1(1), PLCG1(1), VAV1(4) 1101673 10 3 10 1 2 3 0 2 2 1 0.152 0.710 1.000 103 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(1) 289160 3 1 3 0 0 2 0 0 1 0 0.447 0.716 1.000 104 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), SDHA(3) 567857 4 2 4 0 2 0 0 0 2 0 0.356 0.720 1.000 105 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 UGDH(2) 333282 2 2 2 2 0 0 0 1 1 0 0.993 0.721 1.000 106 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(8), MDM2(1), PIK3CA(1), PIK3R1(1), POLR1A(3), POLR1B(2), RB1(1) 1557357 17 4 16 3 3 3 5 1 5 0 0.272 0.727 1.000 107 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 JAK1(2), JAK2(2), TYK2(1) 756016 5 3 4 1 1 0 1 0 3 0 0.674 0.727 1.000 108 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 JAK1(2), JAK2(2), TYK2(1) 756016 5 3 4 1 1 0 1 0 3 0 0.674 0.727 1.000 109 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(2), EIF4A2(1), EIF4G1(9), EIF4G3(5), GHR(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1) 2092030 22 8 20 4 4 6 3 3 6 0 0.257 0.729 1.000 110 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), DPYD(4), DPYS(4), ENPP3(2), PANK4(1), UPB1(2) 1213960 15 6 15 3 3 5 2 2 3 0 0.223 0.733 1.000 111 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 28 EGFR(2), GNAS(6), GNB1(1), HRAS(1), IGF1R(4), KLK2(1), NGFR(1), PDGFRA(8), RPS6KA1(1), RPS6KA5(1), SHC1(1), SOS1(3), SRC(1), STAT3(1) 2817618 32 12 28 8 9 5 5 4 9 0 0.438 0.739 1.000 112 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(3), FH(1), IDH2(3), IDH3A(2), MDH2(1), OGDH(5), PC(2), PDHA1(1), PDK1(1), PDK2(1), SDHA(3), SUCLA2(1), SUCLG1(1) 2452323 25 6 23 4 8 3 3 4 7 0 0.129 0.744 1.000 113 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(3), ATM(6), CCND1(1), CCNE1(1), CDK4(2), MDM2(1), RB1(1) 1492424 15 4 15 3 3 3 4 2 3 0 0.427 0.753 1.000 114 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(3), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), LMNB1(1), LMNB2(1), PRF1(3) 1667335 19 7 18 3 4 5 2 1 7 0 0.252 0.753 1.000 115 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 12 CASR(3), GABBR1(5), GPRC5A(2), GPRC5B(4), GPRC5C(5), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM7(4), GRM8(2) 1592308 34 8 30 9 6 10 4 3 11 0 0.318 0.757 1.000 116 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA3(2), LPO(4), MPO(2), TPO(3) 726403 15 3 15 5 8 0 4 1 2 0 0.471 0.761 1.000 117 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), GSK3B(1), IGF1R(4), INPPL1(3), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1) 1696671 15 6 15 4 3 3 0 3 6 0 0.570 0.769 1.000 118 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(2), PC(2), PDHA1(1), SLC25A1(1) 800665 8 2 8 3 3 4 0 1 0 0 0.444 0.769 1.000 119 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), HRAS(1), JAK1(2), MAP2K4(2), MAP3K1(3), MAPK8(1), PDGFRA(8), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5A(1) 3013300 30 9 26 7 4 4 5 6 11 0 0.594 0.770 1.000 120 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 10 ARNTL(1), CRY1(1), CSNK1D(1), CSNK1E(1), NPAS2(3), PER1(2), PER2(3) 1336311 12 3 12 1 3 2 2 3 2 0 0.0698 0.774 1.000 121 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(2), ARPC2(1), CDC42(1), WASF1(1) 609705 5 3 5 3 1 2 0 2 0 0 0.796 0.775 1.000 122 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(4), F5(3), FGA(3), FGB(4), FGG(1), PROC(1), PROS1(1), SERPINC1(2), TFPI(2) 1405235 21 4 21 3 3 6 9 3 0 0 0.0979 0.778 1.000 123 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR171(1), GPR18(1), GPR39(3), GPR75(1) 845494 7 3 7 3 1 1 0 3 2 0 0.781 0.782 1.000 124 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(2), CD80(1) 340531 3 1 3 1 0 0 1 1 1 0 0.845 0.782 1.000 125 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), CAMKK1(1), CREB1(1) 1006344 7 3 7 0 2 1 2 0 2 0 0.148 0.790 1.000 126 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 UGDH(2), UGP2(2) 422587 4 3 4 2 0 1 0 2 1 0 0.920 0.790 1.000 127 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(3), BMPR2(1) 537379 9 3 9 2 2 3 1 1 2 0 0.451 0.793 1.000 128 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 9 AKT1(2), JAK1(2), JAK3(3), SHC1(1), STAT6(1) 933110 9 4 8 7 2 1 1 1 4 0 0.992 0.795 1.000 129 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA4(5), GABRA5(3), GABRA6(1), SRC(1), UBQLN1(3) 1038405 15 2 15 1 4 3 4 2 1 1 0.0350 0.799 1.000 130 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1S(5), C3(5), C6(6), C7(3), C8A(3), C9(1) 1509534 24 8 22 6 2 5 5 5 7 0 0.525 0.799 1.000 131 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 MAP2(2), PPP1CA(1), PRKACG(2), PRKAR2B(1), PRKCE(1) 893050 7 2 7 0 3 3 1 0 0 0 0.0671 0.800 1.000 132 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(1), CHST12(1), PAPSS1(2), PAPSS2(3), SULT1A2(1), SULT2A1(1) 804074 11 4 11 2 2 2 1 3 3 0 0.344 0.801 1.000 133 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), ATIC(1), DHFR(1), FTCD(2), MTFMT(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), SHMT1(1), SHMT2(3), TYMS(1) 1411478 20 7 18 5 3 3 4 2 8 0 0.430 0.803 1.000 134 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR6(1), NFS1(1), PHPT1(1), TPK1(1) 550789 4 2 4 2 0 2 1 0 1 0 0.902 0.803 1.000 135 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 CASP2(2), CASP8(2), CRADD(2), LMNB1(1), LMNB2(1), MADD(3), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(6), RB1(1), SPTAN1(2), TNFRSF1A(2), TRADD(1), TRAF2(1) 3378256 36 11 33 5 10 1 9 4 11 1 0.135 0.810 1.000 136 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(2), LPO(4), MPO(2), PRDX1(1), TPO(3), TYR(2) 836919 18 3 18 6 9 0 6 1 2 0 0.443 0.810 1.000 137 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(1), GPI(1), HK1(2), PFKL(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2) 805357 12 2 12 4 2 5 1 2 2 0 0.317 0.811 1.000 138 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(3), NFKBIA(2), RELA(1) 788619 7 3 7 3 0 1 2 2 2 0 0.803 0.816 1.000 139 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), FH(1), IDH1(1), IDH2(3), IDH3A(2), MDH2(1), PC(2), PCK1(2), SDHA(3), SUCLA2(1), SUCLG1(1) 1772020 19 5 18 1 4 3 4 4 4 0 0.0411 0.821 1.000 140 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), LCT(3), PGM1(1), PYGM(2), TPI1(2) 1167521 10 3 10 9 1 2 2 1 4 0 0.948 0.823 1.000 141 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), HRAS(1), NGFR(1), NTRK1(2), PIK3CA(1), PIK3CD(1), SHC1(1), SOS1(3) 1427480 12 5 12 6 5 1 0 2 4 0 0.883 0.823 1.000 142 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), GAD1(5), GAD2(4), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1) 2223655 21 6 21 4 5 5 4 4 2 1 0.154 0.823 1.000 143 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 760971 9 3 8 0 1 1 2 2 3 0 0.184 0.825 1.000 144 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 145540 1 1 1 1 0 0 1 0 0 0 0.968 0.826 1.000 145 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), SHMT1(1), SHMT2(3) 367490 6 1 6 3 2 1 2 0 1 0 0.735 0.826 1.000 146 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), HRAS(1), IGF1R(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SHC1(1), SOS1(3) 1928801 15 5 15 6 3 2 0 4 6 0 0.857 0.827 1.000 147 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(2), JAK1(2), STAT1(1), STAT2(1), TYK2(1) 934636 9 3 8 2 3 0 2 2 2 0 0.527 0.827 1.000 148 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(1), EIF4B(2), EIF4G1(9), EIF4G3(5), FKBP1A(1), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), TSC1(2), TSC2(4) 2383621 30 8 28 8 7 8 5 3 7 0 0.453 0.833 1.000 149 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 8 EIF2AK3(3), EIF2B5(1), EIF5(1), GSK3B(1), PPP1CA(1) 704023 7 2 7 0 1 2 1 0 3 0 0.173 0.836 1.000 150 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), SHMT1(1) 1222597 10 3 10 1 2 2 3 1 2 0 0.196 0.837 1.000 151 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), SHMT1(1) 1222597 10 3 10 1 2 2 3 1 2 0 0.196 0.837 1.000 152 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 20 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), SHMT1(1) 1222597 10 3 10 1 2 2 3 1 2 0 0.196 0.837 1.000 153 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1) 884423 9 2 9 4 3 1 2 0 3 0 0.590 0.837 1.000 154 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 11 ARF1(1), ARFGAP1(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(3), GPLD1(2), KDELR2(1), KDELR3(1) 1303481 15 2 15 0 3 2 3 4 2 1 0.0103 0.840 1.000 155 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 16 ACTA1(2), ARPC2(1), NCK1(3), NCKAP1(4), NTRK1(2), WASF1(1), WASF2(2) 1139415 15 4 15 3 6 4 1 3 1 0 0.225 0.840 1.000 156 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(2), AKT1(2), ATM(6), CSNK1D(1), FHL2(1), HIC1(1), HIF1A(1), MAPK8(1), MDM2(1) 1737889 16 4 16 4 1 2 4 4 5 0 0.543 0.841 1.000 157 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(2), EP300(4), ESR1(1), SRC(1) 1293597 8 3 8 1 1 2 2 1 2 0 0.274 0.848 1.000 158 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP10(1), CASP7(1), CASP8(2), CFLAR(2), LMNB1(1), LMNB2(1), MAP2K4(2), MAP3K1(3), MAP3K7(2), MAPK8(1), PAK1(2), PAK2(2), PRKDC(6), PTPN13(3), RB1(1), SPTAN1(2) 3417567 32 10 29 8 4 2 7 6 12 1 0.670 0.849 1.000 159 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 11 AHCY(2), PAPSS1(2), PAPSS2(3), SCLY(2) 912006 9 2 9 7 2 2 2 1 2 0 0.926 0.849 1.000 160 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), DPYD(4), DPYS(4), ENPP3(2), ILVBL(2), PANK4(1), UPB1(2), VNN1(1) 1506150 19 6 19 3 5 6 3 2 3 0 0.0882 0.851 1.000 161 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(2), EPHA4(2), ITGA1(4), L1CAM(1), RAP1B(1), SELP(3) 1245848 13 4 13 2 4 3 1 2 3 0 0.141 0.852 1.000 162 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), HRAS(1), INSR(4), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PTPN6(4), RPS6KA1(1), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1) 2639601 22 8 22 4 6 3 4 3 6 0 0.251 0.855 1.000 163 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CHUK(1), GHR(1), NFKBIA(2), PIK3CA(1), PIK3R1(1), RELA(1), YWHAH(1) 1223327 11 4 11 3 0 3 3 1 4 0 0.585 0.855 1.000 164 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(4), CDH1(1), CREBBP(2), EP300(4), MAP3K7(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4) 2206311 22 7 20 5 7 2 3 4 6 0 0.438 0.858 1.000 165 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(3), CSF1(1), IL1B(1), TGFB1(1), TGFB2(2), TNFRSF1A(2), TNFRSF1B(2), TNFSF8(3) 1171760 17 7 16 5 4 1 5 3 4 0 0.496 0.859 1.000 166 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HADHA(1), HSD17B4(2), NTAN1(2), SIRT1(1) 1020230 6 3 6 0 1 0 1 2 2 0 0.339 0.860 1.000 167 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), MUT(2) 426371 3 1 3 2 0 0 0 1 2 0 0.905 0.862 1.000 168 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(2), PDK2(1), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), SHC1(1), SOS1(3) 1676503 15 6 15 3 3 5 0 2 5 0 0.278 0.863 1.000 169 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CXCR4(3), GNAQ(1), MAPK8(1), PLCG1(1) 1189126 6 2 6 2 0 2 1 1 2 0 0.516 0.863 1.000 170 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(3), CDC25C(2), GNAI1(1), GNAS(6), GNB1(1), HRAS(1), MYT1(9), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), SRC(1) 1801182 33 10 29 8 11 8 4 4 6 0 0.242 0.864 1.000 171 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNG(1), MUSK(3), PIK3CA(1), PIK3R1(1), PTK2(3), SRC(1), TERT(3), YWHAH(1) 1436502 17 5 17 3 3 4 0 4 6 0 0.186 0.865 1.000 172 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 5 CSF1(1), IL1B(1), MST1R(3) 438412 5 2 5 2 0 3 0 0 2 0 0.527 0.869 1.000 173 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(2), EGFR(2), IGF1R(4), POLR2A(2), RB1(1), TEP1(7), TERF1(2), TERT(3), TNKS(3), XRCC5(2) 2289063 28 9 25 9 8 5 2 5 8 0 0.624 0.873 1.000 174 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(1), IL6(2), JAK1(2), STAT1(1), STAT3(1), STAT5A(1) 1046991 10 4 9 2 3 2 3 0 2 0 0.321 0.874 1.000 175 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), CAMP(2), DAG1(2), GNAQ(1), ITPKB(3) 533277 9 2 9 1 3 0 1 2 3 0 0.215 0.874 1.000 176 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), B4GALT5(2), ST3GAL1(2) 689852 5 2 5 1 1 0 2 1 1 0 0.665 0.876 1.000 177 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACADS(1), ACAT1(2), HADHA(1) 466393 5 1 5 0 0 3 1 0 1 0 0.238 0.876 1.000 178 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD80(1), CD86(1), ITK(1), LCK(1), PIK3CA(1), PIK3R1(1) 1063471 6 2 6 3 1 1 1 1 2 0 0.850 0.876 1.000 179 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(3), AKT1(2), BAD(1), CSF2RB(1), IGF1R(4), KIT(3), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), YWHAH(1) 1853392 23 4 23 4 7 5 3 4 4 0 0.0820 0.876 1.000 180 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(2), JAK3(3), STAT3(1), TYK2(1) 1028013 9 3 8 5 2 2 2 0 3 0 0.869 0.878 1.000 181 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B5(1), ELAVL1(1), FLT1(2), FLT4(8), HIF1A(1), HRAS(1), KDR(1), NOS3(6), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3), SHC1(1) 2945460 28 8 28 4 7 5 8 1 7 0 0.0590 0.878 1.000 182 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), MTHFR(1), SHMT1(1), SHMT2(3), TPO(3) 1001311 20 3 20 6 8 3 4 2 3 0 0.302 0.878 1.000 183 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(1), CDK4(2), MDM2(1), NXT1(1) 610899 6 2 6 0 3 0 2 0 1 0 0.210 0.880 1.000 184 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(3), AASS(1), KARS(1) 593879 5 2 5 3 0 0 3 1 1 0 0.964 0.881 1.000 185 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(4), AXIN1(3), CCND1(1), CD14(2), CTNNB1(6), DVL1(4), FZD1(4), GNAI1(1), GSK3B(1), LEF1(2), LY96(1), PIK3CA(1), PIK3R1(1), RELA(1), WNT1(1) 2679433 35 9 35 5 11 7 5 7 5 0 0.0420 0.882 1.000 186 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1S(5), C3(5), C6(6), C7(3), C8A(3), C9(1), MASP1(1) 1790185 25 8 23 6 2 5 5 6 7 0 0.482 0.883 1.000 187 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 CDC42(1), CREB1(1), HRAS(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAP3K9(2), MAPKAPK2(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), RPS6KA5(1), SHC1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1) 2984577 31 13 28 7 7 2 7 3 12 0 0.500 0.884 1.000 188 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), EPX(4), LPO(4), MPO(2), PRDX1(1), SHMT1(1), SHMT2(3), TPO(3) 1023769 20 3 20 5 8 3 5 1 3 0 0.193 0.886 1.000 189 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 EEF1B2(1), EEF1D(3), EEF1G(3), EEF2(3), EIF2AK2(1), EIF2AK3(3), EIF2B5(1), EIF4A2(1), EIF4G1(9), EIF4G3(5), EIF5(1), EIF5B(3), KIAA0664(1), SLC35A4(2) 3598371 37 10 35 3 5 7 8 7 10 0 0.0173 0.887 1.000 190 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(2), ACSS1(1), ACSS2(2), FH(1), IDH1(1), IDH2(3), MDH2(1), SUCLA2(1) 1136616 14 5 13 2 5 1 2 2 4 0 0.265 0.888 1.000 191 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(2), EGFR(2), ERBB3(3), NRG1(3), UBE2D1(1) 882106 11 3 11 2 1 2 3 2 3 0 0.415 0.888 1.000 192 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 742852 8 4 8 4 3 0 3 0 2 0 0.753 0.888 1.000 193 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(2), HK2(2), HK3(2), ISYNA1(1), PGM1(1), PGM3(1) 1016390 10 2 10 5 4 1 2 0 3 0 0.613 0.889 1.000 194 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(2), CREB1(1), EDN1(1), EP300(4), HIF1A(1), NOS3(6) 1470519 15 3 15 2 3 2 4 2 4 0 0.211 0.889 1.000 195 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(1) 183461 3 1 3 0 0 1 2 0 0 0 0.409 0.892 1.000 196 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H3(2), NR1H4(2) 465961 4 1 4 1 0 2 1 0 1 0 0.452 0.892 1.000 197 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 15 AHCY(2), AMD1(1), DNMT1(2), DNMT3A(4), DNMT3B(2), MTFMT(2) 1413795 13 5 11 8 3 1 3 1 5 0 0.961 0.893 1.000 198 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA4(5), GABRA5(3), GABRA6(1), PRKCE(1), SOD1(1) 680877 11 2 11 2 3 3 1 1 2 1 0.190 0.893 1.000 199 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1S(5), C3(5), C6(6), C7(3), C8A(3), C9(1), MASP1(1) 1837827 25 8 23 7 2 5 5 6 7 0 0.594 0.895 1.000 200 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), BPNT1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PTEN(1), RBL2(2), SHC1(1), SOS1(3) 1759494 14 6 14 5 2 3 1 4 4 0 0.733 0.897 1.000 201 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 DNMT1(2), MTNR1A(1), PTGDR(2), PTGFR(1), TBXA2R(1) 999644 7 3 6 5 1 1 3 0 2 0 0.938 0.898 1.000 202 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(2), SHMT1(1), SHMT2(3) 485875 6 1 6 3 2 1 2 0 1 0 0.763 0.898 1.000 203 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 EPOR(2), HIF1A(1), JAK2(2), NFKBIA(2), RELA(1) 959328 8 2 8 1 2 1 4 0 1 0 0.377 0.900 1.000 204 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), SLC23A2(2), SLC2A1(2) 2184023 23 7 22 5 3 5 7 1 6 1 0.517 0.900 1.000 205 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K6(3), MAP3K1(3), PIK3CA(1), PIK3R1(1), RB1(1), RELA(1), SP1(1) 1680605 14 5 13 5 1 1 6 2 4 0 0.858 0.901 1.000 206 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(1), IL12B(1), IL6(2), IL7(1), TGFB1(1), TGFB2(2) 1160604 10 4 9 2 1 2 2 2 3 0 0.462 0.902 1.000 207 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLD2(1), POLE(7), POLG(5), POLL(3), POLQ(2) 1452002 19 5 19 2 5 4 3 1 6 0 0.0815 0.906 1.000 208 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), GNAS(6), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SLC9A3R1(1) 1149627 18 4 17 4 8 6 3 1 0 0 0.162 0.907 1.000 209 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(2), ABCB11(2), ABCB4(5), ABCC3(2), GSTP1(1) 1231186 12 5 10 3 0 3 1 3 5 0 0.634 0.911 1.000 210 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(2), EP300(4), IL7(1), IL7R(1), JAK1(2), JAK3(3), LCK(1), PIK3CA(1), PIK3R1(1), STAT5A(1), STAT5B(1) 2325064 18 7 17 7 4 3 3 2 6 0 0.771 0.912 1.000 211 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(2), HRAS(1), KLK2(1), MAPK8(1), NGFR(1), PIK3CA(1), PIK3R1(1), PLCG1(1), SHC1(1), SOS1(3) 1656727 13 5 13 4 2 3 1 2 5 0 0.702 0.914 1.000 212 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(2), B3GAT3(1), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHSY1(1), DSE(2), XYLT1(2), XYLT2(4) 1292106 16 8 14 9 7 2 2 1 4 0 0.809 0.914 1.000 213 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS2(2), GOT1(2), LDHB(1), SULT1B1(2), SULT1C4(1), SULT4A1(1) 1085208 9 3 8 1 1 1 2 2 3 0 0.384 0.918 1.000 214 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(2), CPOX(1), PPOX(2) 661850 5 4 5 2 1 2 1 0 1 0 0.779 0.919 1.000 215 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 10 AHCY(2), DNMT1(2), DNMT3A(4), DNMT3B(2) 1122424 10 4 9 7 3 1 3 1 2 0 0.946 0.920 1.000 216 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(2), CCNA2(3), CCND1(1), CCNE1(1), CCNE2(1), CDK4(2), E2F4(3) 735587 13 2 13 2 2 2 5 3 1 0 0.288 0.921 1.000 217 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 CDK5(1), CDK5R1(1), HRAS(1), KLK2(1), NGFR(1) 627865 5 3 5 3 3 0 1 0 1 0 0.897 0.921 1.000 218 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(3), ARHGEF1(3), F2RL3(1), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(2), PIK3CA(1), PIK3R1(1), PLCB1(1), ROCK1(2) 2243034 17 6 16 3 2 3 3 3 6 0 0.331 0.922 1.000 219 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), GLB1(1), HEXB(1), LCT(3), MANBA(2), NEU4(1) 1452219 11 4 11 4 4 1 2 0 4 0 0.563 0.924 1.000 220 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(2), JAK3(3), PIAS1(1), PIAS3(1), PTPRU(6), SOAT1(1) 1197602 16 6 15 8 6 3 4 0 3 0 0.842 0.924 1.000 221 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1B(1), PRMT3(1), PRMT6(1), PRMT8(1) 1219211 10 3 10 3 0 3 5 0 2 0 0.662 0.924 1.000 222 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2) 224768 2 1 2 0 0 0 1 1 0 0 0.652 0.924 1.000 223 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 14 ACOX3(1), PLA2G3(2), PLA2G6(3) 805917 6 2 6 4 0 2 2 1 1 0 0.932 0.924 1.000 224 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(1), ALPI(4), ALPL(1), ALPP(4), ALPPL2(2), CYP3A7(3), DHRS1(1), DHRS3(2), PON1(1), PON2(1) 1562047 20 6 19 5 7 3 1 4 5 0 0.312 0.925 1.000 225 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(3), PRKACG(2), PRKAR2B(1) 869441 6 2 6 0 1 2 1 1 1 0 0.185 0.927 1.000 226 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(3), GNAQ(1), GNB1(1), MYLK(8), PLCB1(1), ROCK1(2) 1779621 19 5 18 7 2 3 4 4 6 0 0.772 0.927 1.000 227 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR2(1), ATP8A1(3), AVPR1B(1), AVPR2(1), C3AR1(2), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CXCR4(3), EDNRB(2), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GNRHR(1), GPR77(1), GRPR(1), MC2R(2), MC3R(2), MC5R(1), NPY1R(1), NPY2R(3), NPY5R(1), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), SSTR1(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(1), TRHR(1), TSHR(3) 4466353 62 15 62 16 20 8 17 10 6 1 0.0220 0.929 1.000 228 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(4), AXIN1(3), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMPR1A(3), BMPR2(1), CTNNB1(6), DVL1(4), FZD1(4), GATA4(1), GSK3B(1), MAP3K7(2), RFC1(3), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), WNT1(1) 3018270 48 10 46 6 18 9 5 11 5 0 0.00648 0.930 1.000 229 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(2), HSD3B7(2), PON1(1), PON2(1), RDH11(2) 774976 9 2 9 2 2 1 2 3 1 0 0.450 0.931 1.000 230 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(2), CCND1(1), CCND2(1), CCND3(1), CCNE1(1), CDC25A(2), CDK4(2), CDK7(1), RB1(1), RBL1(1) 1344187 13 4 12 5 1 2 3 3 4 0 0.837 0.932 1.000 231 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(2), APAF1(3), ATM(6), BAD(1), CASP7(1), PTK2(3), STAT1(1), TLN1(7) 2253406 24 4 24 4 6 8 3 3 4 0 0.0836 0.934 1.000 232 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(2), GLI2(2), GLI3(6), GSK3B(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), SMO(2), SUFU(1) 1457169 23 7 23 8 9 5 7 1 1 0 0.386 0.934 1.000 233 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 4342535 49 11 48 8 14 9 8 9 9 0 0.0223 0.935 1.000 234 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 49 ABL1(8), ARPC5(1), ARPC5L(1), CD14(2), CDC42(1), CDH1(1), CTNNB1(6), LY96(1), NCK1(3), NCK2(2), NCL(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 4342535 49 11 48 8 14 9 8 9 9 0 0.0223 0.935 1.000 235 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), JAK1(2), JAK2(2), JAK3(3), STAT1(1), STAT3(1), STAT5A(1), STAT5B(1), TYK2(1) 1607144 13 4 12 6 4 2 3 0 4 0 0.792 0.937 1.000 236 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1) 601181 7 2 7 2 2 2 0 2 1 0 0.555 0.937 1.000 237 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(3), LCK(1), MAPK8(1), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(2) 2048680 21 8 20 9 6 4 1 3 7 0 0.855 0.939 1.000 238 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), UBE3A(3) 1109524 10 4 10 4 3 0 2 1 4 0 0.849 0.939 1.000 239 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS2(1), OXCT1(1) 623763 5 1 5 1 0 3 0 0 2 0 0.420 0.939 1.000 240 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2M1(1), BIN1(1), DNM1(2), EPN1(2), EPS15(1), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ2(4) 1916732 17 6 16 5 2 4 2 2 7 0 0.603 0.940 1.000 241 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), PRF1(3), SCAP(1) 1432397 12 4 11 3 2 4 0 1 5 0 0.359 0.940 1.000 242 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), HRAS(1), JAK2(2), PTPN6(4), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1) 1523724 14 5 14 3 3 1 3 3 4 0 0.515 0.940 1.000 243 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGT(2), AGTR2(1), ANPEP(2), CMA1(1), CTSG(1), ENPEP(3), LNPEP(2), MME(2), REN(4), THOP1(1) 1824729 22 8 19 4 3 5 4 4 6 0 0.247 0.941 1.000 244 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNAQ(1), GNB1(1), PLCB1(1), TUB(1) 613657 4 1 4 1 0 1 0 2 1 0 0.577 0.941 1.000 245 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(3), FBL(1), GPT(1), LDHB(1), NCL(1) 779972 9 2 9 3 2 1 4 1 1 0 0.667 0.942 1.000 246 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 EGF(2), EGFR(2), HRAS(1), PTPRB(8), RASA1(1), SHC1(1), SOS1(3), SPRY4(2), SRC(1) 1996705 21 6 20 3 1 7 2 5 5 1 0.171 0.944 1.000 247 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH3A1(1), UGDH(2) 739390 4 2 4 2 2 0 0 1 1 0 0.852 0.944 1.000 248 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 14 ALDH1L1(4), ATIC(1), DHFR(1), MTHFD1L(3), MTHFD2(1), MTHFR(1), SHMT1(1), SHMT2(3), TYMS(1) 1313562 16 4 15 3 2 2 4 2 6 0 0.270 0.944 1.000 249 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), ANXA1(1), GNAS(6), GNB1(1), NOS3(6), NR3C1(2), PIK3CA(1), PIK3R1(1), RELA(1) 1574187 21 5 20 5 5 3 8 2 3 0 0.515 0.945 1.000 250 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(4), F12(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), LPA(3), PLAT(1), PLAU(3), SERPINB2(1), SERPINE1(1), SERPINF2(1), VWF(4) 3030724 33 7 32 5 9 8 11 2 3 0 0.0420 0.946 1.000 251 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), DHRS1(1), DHRS3(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1) 1294451 11 3 11 4 0 3 5 1 2 0 0.731 0.947 1.000 252 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(2), BAD(1), CDC42(1), CHUK(1), HRAS(1), PIK3CA(1), PIK3R1(1), RALBP1(2), RALGDS(1), RELA(1) 1634120 12 4 12 5 2 4 1 2 3 0 0.771 0.948 1.000 253 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 34 AKT1(2), ATF1(1), CDC42(1), CREB1(1), DUSP10(1), MAP2K4(2), MAP2K6(3), MAP3K10(3), MAP3K7(2), MAPK11(1), MAPK12(1), MAPKAPK2(1), MAPKAPK5(1), MYEF2(1), NR2C2(1) 2661656 22 9 20 6 4 3 4 3 8 0 0.507 0.949 1.000 254 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2E2(1), GTF2F1(2), GTF2H1(1), GTF2H4(1), GTF2I(1), GTF2IRD1(1), TAF1(4), TAF1L(3), TAF2(2), TAF4(1), TAF4B(2), TAF5(1), TAF5L(1), TAF6L(2) 3099549 23 8 23 8 7 2 5 4 5 0 0.763 0.949 1.000 255 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(2), JAK1(2), JAK2(2), JAK3(3), PIAS3(1), PTPRU(6), SRC(1), STAT3(1) 1329354 18 6 17 8 5 5 5 0 3 0 0.717 0.951 1.000 256 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), APOA4(1), CYP7A1(2), DGAT1(2), HMGCR(1), LPL(2), LRP1(12), SCARB1(1), SOAT1(1) 2356959 24 7 21 5 9 4 3 1 7 0 0.137 0.952 1.000 257 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), DHFR(1), IMPDH1(2), MTHFD2(1), POLD1(1), POLG(5), RRM1(1) 1111876 13 4 13 2 3 5 0 1 4 0 0.0994 0.953 1.000 258 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(3) 265293 5 1 5 1 0 1 1 3 0 0 0.595 0.953 1.000 259 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCR(1), HRAS(1), JAK2(2), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), SOS1(3), STAT1(1), STAT5A(1), STAT5B(1) 2343134 20 6 20 5 3 2 5 4 6 0 0.534 0.955 1.000 260 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT2(1), B4GALT5(2), DDOST(1), DPAGT1(2), MAN1B1(1), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), ST6GAL1(1) 1741660 13 6 12 4 4 1 1 2 5 0 0.742 0.955 1.000 261 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IL12B(1), IL16(1), IL6(2) 850791 4 3 4 2 0 1 2 0 1 0 0.831 0.957 1.000 262 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(3), BAK1(1), BIRC2(1), CASP7(1), CASP8(2) 1108786 8 2 8 2 2 3 0 1 2 0 0.376 0.958 1.000 263 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPNS1(3), EP300(4), MEF2D(1), NFATC1(4), NFATC2(4), PPP3CA(1), PPP3CC(1) 2097941 20 7 20 7 5 6 0 2 7 0 0.450 0.959 1.000 264 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), HRAS(1), INSR(4), MAPK8(1), PIK3CA(1), PIK3R1(1), RASA1(1), SHC1(1), SOS1(3) 1994744 15 5 15 5 4 2 0 4 5 0 0.706 0.959 1.000 265 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(4), AXIN1(3), BTRC(1), CCND1(1), CREBBP(2), CSNK1D(1), CSNK2A1(2), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), MAP3K7(2), NLK(1), PPARD(1), TLE1(2), WIF1(1), WNT1(1) 2500282 37 10 36 7 10 7 6 7 7 0 0.137 0.960 1.000 266 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(3), ALDH5A1(1), CAD(4), CPS1(4), GAD1(5), GAD2(4), GFPT1(1), GFPT2(1), GLS(1), GLUD2(1), GOT1(2), GPT(1), GPT2(2), NADSYN1(3), NAGK(1), PPAT(2), QARS(1) 3408057 38 10 38 10 7 6 14 5 4 2 0.305 0.960 1.000 267 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(1), GFPT1(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), PGM3(1), RENBP(1) 1467187 17 4 17 6 6 3 4 1 3 0 0.422 0.961 1.000 268 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), IL1B(1), MAP2K6(3), MAP3K7(2), MAPK11(1), NFKBIA(2), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(4), TLR2(1) 2574604 28 7 26 5 5 5 7 4 7 0 0.140 0.963 1.000 269 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(2), EGFR(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), MEF2A(1), MEF2D(1), PAK1(2), PTK2(3), SHC1(1), SOS1(3), SRC(1) 2905959 24 7 22 7 2 4 3 4 11 0 0.668 0.967 1.000 270 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 KERA(2), LUM(1) 311184 3 1 3 1 0 1 0 2 0 0 0.631 0.967 1.000 271 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1) 1420605 9 4 9 5 1 2 0 3 3 0 0.901 0.968 1.000 272 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(2), GNAQ(1), HRAS(1), MAP2K4(2), MAP3K1(3), MAPK8(1), PAK1(2), PLCG1(1), SHC1(1), SOS1(3), SRC(1) 2474345 18 5 17 7 2 4 3 3 6 0 0.813 0.970 1.000 273 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), POLR2A(2), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1116229 9 3 9 2 4 2 2 0 1 0 0.365 0.970 1.000 274 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), UBE2J1(1), UBE2S(1), UBE3A(3) 909483 10 2 10 0 5 2 2 0 1 0 0.0329 0.970 1.000 275 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(2), EP300(4), NCOA3(3), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1782717 17 4 17 6 5 2 4 2 3 1 0.598 0.971 1.000 276 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(1), PDE1B(1), PLCB1(1), PLCB2(3), PRL(1), TRH(2) 969078 10 3 10 4 4 1 2 1 2 0 0.637 0.971 1.000 277 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 CDK5(1), CDK5R1(1), CSNK1D(1), DRD1(2), DRD2(1), PLCB1(1), PPP1CA(1), PPP3CA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1172950 15 3 15 3 8 2 1 3 1 0 0.194 0.971 1.000 278 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 25 AHCY(2), CARM1(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PAPSS1(2), PAPSS2(3), PRMT3(1), PRMT6(1), PRMT8(1), SCLY(2) 1997430 17 3 17 9 2 4 7 1 3 0 0.864 0.972 1.000 279 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA2(1), PSMA5(1), PSMB1(1), PSMB4(1), PSMB5(1), PSMD1(2), PSMD11(1), PSMD12(1) 1369197 11 4 11 7 1 1 3 3 3 0 0.963 0.972 1.000 280 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), RPE(2), UGDH(2), UGT1A1(2), UGT2B15(1), UGT2B4(1) 1500472 9 3 9 2 1 2 2 1 3 0 0.518 0.972 1.000 281 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(2), HRAS(1), JAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5A(1), STAT5B(1), THPO(1) 2575485 18 5 18 5 2 5 2 3 6 0 0.609 0.973 1.000 282 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(3), APC(4), AXIN1(3), BTRC(1), CTNNB1(6), DVL1(4), FZD1(4), GSK3B(1), NOTCH1(7), PSEN1(1), WNT1(1) 1909871 35 6 34 6 12 11 4 5 3 0 0.0188 0.973 1.000 283 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(4), AXIN1(3), CREBBP(2), CTNNB1(6), DVL1(4), EP300(4), FZD1(4), GSK3B(1), LDB1(1), LEF1(2), TRRAP(7), WNT1(1) 2871748 39 7 39 7 13 8 6 9 3 0 0.0326 0.974 1.000 284 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(3), COL4A2(5), COL4A3(1), COL4A4(4), COL4A5(3), COL4A6(3), F10(4), F12(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), PROC(1), PROS1(1), SERPINC1(2), SERPING1(1) 3841222 43 9 43 4 6 10 18 3 5 1 0.0141 0.975 1.000 285 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 BCMO1(1) 331945 1 1 1 0 0 0 0 1 0 0 0.797 0.975 1.000 286 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 11 ACAA1(1), ACOX3(1), FADS1(1), FASN(9), HADHA(1) 1145968 13 3 13 3 4 4 3 0 1 1 0.136 0.975 1.000 287 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(1), GLB1(1), HEXB(1), LCT(3), NAGLU(2) 1269885 10 4 10 5 2 3 1 0 4 0 0.658 0.976 1.000 288 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(1), GREB1(3), MTA1(1), PDZK1(2), TUBA8(2) 965242 10 3 10 2 0 5 1 2 2 0 0.198 0.976 1.000 289 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 1765782 20 4 20 5 5 4 7 2 2 0 0.181 0.978 1.000 290 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(2), HRAS(1), JAK2(2), MAPK8(1), PLCG1(1), PTPN6(4), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1) 1868758 19 6 19 5 5 2 3 3 6 0 0.544 0.978 1.000 291 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH5A1(1), BDH1(1), DDHD1(2), GAD1(5), GAD2(4), HADHA(1), HMGCS2(1), HSD17B4(2), HSD3B7(2), ILVBL(2), L2HGDH(1), OXCT1(1), PDHA1(1), PLA1A(1), RDH11(2) 3511983 34 8 34 7 8 8 7 7 3 1 0.0822 0.978 1.000 292 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(2), HRAS(1), PML(1), RB1(1), SIRT1(1), SP100(4), TNFRSF1A(2), TNFRSF1B(2) 1453670 14 4 14 3 4 2 4 2 2 0 0.347 0.978 1.000 293 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(3), AKT1(2), CAMK2D(1), CREB1(1), GNAS(6), HRAS(1), PIK3CA(1), PIK3R1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RPS6KA1(1), RPS6KA5(1), SOS1(3) 2535181 27 7 26 4 9 5 4 3 6 0 0.102 0.978 1.000 294 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1), TPI1(2) 333418 4 1 4 0 1 2 0 1 0 0 0.218 0.979 1.000 295 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), GOT1(2), HPD(3), LPO(4), MPO(2), PRDX1(1), TPO(3) 1903218 29 4 29 7 14 3 6 3 3 0 0.110 0.980 1.000 296 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 19 IL12B(1), JAK2(2), MAP2K6(3), MAPK8(1), TYK2(1) 1587459 8 2 7 1 2 1 2 0 3 0 0.197 0.980 1.000 297 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(1), BLNK(1), HRAS(1), MAP3K1(3), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), SHC1(1), SOS1(3), SYK(2), VAV1(4), VAV3(1) 2798487 23 6 23 4 6 3 3 4 6 1 0.144 0.981 1.000 298 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 28 ANXA1(1), ANXA2(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRB(2), HSD11B1(1), PRL(1), PTGDR(2), PTGDS(2), PTGFR(1), PTGIS(2), TBXAS1(1) 1799327 19 5 19 7 8 2 4 3 2 0 0.488 0.981 1.000 299 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(2), EP300(4), LPL(2), NCOA2(2) 1584940 10 4 10 8 2 1 2 1 4 0 0.984 0.981 1.000 300 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 16 ABCG2(1), BCHE(4), UGT1A1(2) 1674633 7 4 7 4 0 2 0 2 3 0 0.885 0.982 1.000 301 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), IARS(2), INPP5D(1), JAK1(2), JAK2(2), JAK3(3), PIK3CA(1), SHC1(1), SOS1(3), SOS2(1), SRC(1), STAT6(1), TYK2(1) 3055257 21 6 20 7 5 3 2 3 8 0 0.715 0.984 1.000 302 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), MAF(3), NFATC1(4), NFATC2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1072401 18 3 18 4 9 5 1 0 3 0 0.0600 0.985 1.000 303 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), FBP2(1), GCK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), PFKFB1(2), PFKFB4(2), PFKM(1), PFKP(1), PMM2(1), TPI1(2) 2079132 23 6 23 6 9 4 6 1 3 0 0.165 0.986 1.000 304 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 ATM(6), CCND2(1), CDK4(2), ESR2(1), FSHR(1), GJA4(1), MLH1(1), NCOR1(6), NRIP1(1), PGR(3), PRLR(2) 2823535 25 5 25 9 6 4 6 5 4 0 0.594 0.986 1.000 305 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), OCRL(1), PIK3C2A(4), PIK3C2B(10), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4) 3881706 41 7 41 6 14 5 4 10 8 0 0.0250 0.987 1.000 306 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(2), EGF(2), EGFR(2), HRAS(1), JAK1(2), MAP2K4(2), MAP3K1(3), MAPK8(1), PIK3CA(1), PIK3R1(1), PLCG1(1), RASA1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5A(1) 3231479 26 6 25 8 2 6 4 6 8 0 0.663 0.988 1.000 307 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(6), FASN(9), MCAT(1) 1413005 20 3 20 4 8 7 2 1 1 1 0.0454 0.988 1.000 308 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 32 A1BG(1), AKT1(2), BAD(1), BTK(1), DAPP1(1), GSK3A(1), GSK3B(1), IARS(2), INPP5D(1), PDK1(1), PIK3CA(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(3), SOS2(1), TEC(2), YWHAE(2), YWHAH(1) 3070432 26 7 26 8 5 8 0 4 9 0 0.484 0.988 1.000 309 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 44 APAF1(3), BAD(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CRADD(2), FAS(1), FASLG(1), IKBKE(1), NFKBIA(2), NGFR(1), NR3C1(2), NTRK1(2), PTPN13(3), TFG(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 3566758 37 9 37 9 11 9 8 2 7 0 0.251 0.988 1.000 310 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT12(1) 1858251 17 3 16 4 6 3 2 2 4 0 0.287 0.989 1.000 311 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IKBKB(2), IL1B(1), IL1RAP(2), IL1RN(1), IL6(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), RELA(1), TGFB1(1), TGFB2(2) 2578259 24 8 21 6 3 2 7 4 8 0 0.488 0.989 1.000 312 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(2), AGT(2), AGTR2(1), EDN1(1), EDNRB(2), EGF(2), EGFR(2), HRAS(1), PLCG1(1), RELA(1) 1687709 15 4 14 2 2 3 3 1 6 0 0.146 0.989 1.000 313 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(2), TYR(2) 401517 4 1 4 1 1 0 2 1 0 0 0.641 0.990 1.000 314 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(1), G6PC2(1), GAA(1), GANC(1), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), HSD3B7(2), LCT(3), PFKL(1), PFKM(1), PFKP(1), PGM1(1), PGM3(1), RDH11(2), UGP2(2) 3360220 27 8 27 9 9 5 5 2 6 0 0.320 0.990 1.000 315 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 20 AARS(1), DARS(1), FARS2(2), GARS(5), IARS(2), KARS(1), LARS2(2), QARS(1), RARS(1), TARS(2), WARS(2) 2572984 20 8 19 3 6 4 6 3 1 0 0.128 0.990 1.000 316 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), ST8SIA1(2) 1418020 11 2 11 1 6 2 2 0 1 0 0.0875 0.990 1.000 317 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP2(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(1), PGD(1), PGLS(1), PGM1(1), PGM3(1), PRPS1(1), PRPS1L1(1), RBKS(1), RPE(2), TKT(1) 2104472 21 4 21 4 5 5 7 2 2 0 0.0814 0.990 1.000 318 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 HADHA(1) 417598 1 1 1 0 0 0 1 0 0 0 0.825 0.990 1.000 319 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(4), ASAH1(1), CAMP(2), CERK(1), CREB1(1), DAG1(2), EPHB2(1), GNAQ(1), ITPKB(3), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1) 2506213 28 5 28 5 9 3 4 6 6 0 0.0938 0.991 1.000 320 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), OAT(2), PYCR1(1) 1540359 16 3 16 2 4 2 6 2 1 1 0.123 0.991 1.000 321 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), CHUK(1), IKBKB(2), LY96(1), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP3K7(2), MAPK8(1), NFKBIA(2), PPARA(1), RELA(1), TLR10(1), TLR2(1), TLR3(2), TLR6(2), TLR9(6) 3167310 33 8 31 8 7 4 8 5 9 0 0.359 0.991 1.000 322 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(1), CREB1(1), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(3), SOS2(1) 2570866 11 6 11 9 2 2 1 1 5 0 0.998 0.991 1.000 323 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT3(3), AGPAT4(4), CHPT1(1), ENPP2(3), PAFAH1B1(1), PAFAH2(2), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2) 2008347 23 4 23 8 6 4 4 4 5 0 0.611 0.992 1.000 324 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), HAL(1) 1634208 12 3 12 2 3 4 2 1 1 1 0.222 0.992 1.000 325 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(1), FBP2(1), GAA(1), GANAB(2), GCK(1), GLB1(1), HK1(2), HK2(2), HK3(2), LCT(3), PFKM(1), PFKP(1), PGM1(1), PGM3(1) 2828284 21 7 21 9 7 2 5 1 6 0 0.637 0.992 1.000 326 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG2(2), AKT1(2), CDC42(1), FLNA(5), FLNC(7), FSCN3(2), GDI1(1), GDI2(1), LIMK1(1), MYH2(2), MYLK(8), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), ROCK1(2), ROCK2(1), WASF1(1) 3993250 46 13 44 14 8 7 12 10 9 0 0.464 0.993 1.000 327 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PDHA1(1), PKLR(1) 3182862 28 3 28 7 5 12 2 3 6 0 0.204 0.993 1.000 328 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2) 480194 8 1 8 3 4 2 1 1 0 0 0.595 0.993 1.000 329 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK5(1), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), TRAF2(1), TRAF5(1) 2986646 23 5 23 6 5 7 4 3 4 0 0.189 0.993 1.000 330 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(2), POLE(7), POLE2(1), POLG(5), POLH(1), POLI(1), POLL(3), POLM(1), POLQ(2), REV3L(3) 3302262 30 8 30 5 6 5 5 6 8 0 0.176 0.993 1.000 331 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), RPE(2), UGDH(2), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1), XYLB(2) 2321377 16 4 16 4 1 6 2 3 4 0 0.453 0.993 1.000 332 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 HSD3B7(2), RDH11(2) 417291 4 1 4 0 1 0 2 1 0 0 0.349 0.994 1.000 333 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 21 ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), FDXR(1), SHMT1(1) 1305874 11 3 11 2 2 2 4 1 2 0 0.314 0.994 1.000 334 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(2), DIAPH2(1), MCM10(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), POLA2(1), POLD1(1), POLD2(1), POLD3(2), POLE(7), POLE2(1), RFC1(3), RFC3(1), RPA1(1), RPA2(1), RPA3(2), RPS27A(1), UBC(1) 4381152 43 13 43 7 11 6 7 7 11 1 0.0618 0.994 1.000 335 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), CP(5), CPOX(1), PPOX(2), UGT1A1(2), UGT2B15(1), UGT2B4(1) 2339583 14 5 14 2 1 4 1 2 6 0 0.273 0.994 1.000 336 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSB(2), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SPTLC1(1), UGCG(1) 2007862 15 4 15 6 5 3 1 1 5 0 0.525 0.994 1.000 337 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), CASP8(2), MAP2K4(2), MAP3K1(3), MAPK8(1), NSMAF(1), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 1679392 15 3 15 6 3 1 5 2 4 0 0.800 0.994 1.000 338 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 GNAQ(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SP1(1) 1811531 19 4 19 4 4 6 2 2 5 0 0.168 0.995 1.000 339 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), CAPN1(1), CAPNS1(3), ITGA1(4), ITGB3(1), PTK2(3), SPTAN1(2), SRC(1), TLN1(7) 2478188 30 4 30 7 10 9 3 2 6 0 0.0783 0.995 1.000 340 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNGR1(2), IKBKB(2), JAK2(2), LIN7A(1), NFKBIA(2), RB1(1), RELA(1), TNFRSF1A(2), TNFRSF1B(2), USH1C(1) 1467866 16 4 16 6 3 2 6 2 3 0 0.680 0.995 1.000 341 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CASP8(2), CFLAR(2), MAP2K4(2), MAP3K7(2), NFKBIA(2), NFKBIE(1), NR2C2(1), RALBP1(2), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 2389802 22 7 21 8 4 2 7 4 5 0 0.724 0.995 1.000 342 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), NAGLU(2) 1799275 14 4 14 9 3 5 2 0 4 0 0.824 0.996 1.000 343 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(2), MAP3K1(3), MAP3K7(2), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1A(2), TNFRSF1B(2), TRADD(1) 2132857 17 6 16 9 2 2 8 2 3 0 0.956 0.996 1.000 344 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), GLB1(1), HEXB(1), LCT(3), MAN2B2(1), MANBA(2), NEU4(1) 1787869 12 4 12 6 5 1 2 0 4 0 0.719 0.996 1.000 345 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(2), CAMK1(1), CAMK1G(1), HDAC5(2), IGF1R(4), INSR(4), MAP2K6(3), MAPK7(4), MEF2A(1), MEF2D(1), NFATC1(4), NFATC2(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), YWHAH(1) 3022915 38 8 37 10 10 8 5 4 11 0 0.193 0.996 1.000 346 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 TGM2(1) 431242 1 1 1 1 1 0 0 0 0 0 0.845 0.996 1.000 347 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), CA6(1), CA8(1), CA9(1), CPS1(4), GLS(1), GLUD2(1), HAL(1) 1827658 13 3 13 3 3 5 2 1 1 1 0.301 0.996 1.000 348 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), SH3GLB1(1) 2143527 19 4 19 9 5 6 1 4 3 0 0.798 0.996 1.000 349 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(4), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GK(2), GLB1(1), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2) 4104835 48 7 48 16 22 5 7 6 8 0 0.236 0.996 1.000 350 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(2), EXT2(2), EXTL2(2), EXTL3(5), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), NDST1(2), NDST3(3), NDST4(2) 1715528 25 3 25 6 10 3 7 2 3 0 0.198 0.996 1.000 351 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 59 ATP12A(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), ATP7A(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA8(1), NDUFS1(1), NDUFV1(1), SDHA(3), SHMT1(1), UQCRFS1(1) 3217419 28 7 28 6 6 6 5 5 5 1 0.224 0.997 1.000 352 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(2), CRK(1), CXCR4(3), GNAI1(1), GNAQ(1), GNB1(1), HRAS(1), PIK3CA(1), PIK3R1(1), PLCG1(1), PTK2(3), RELA(1) 2416272 17 3 17 9 4 6 2 2 3 0 0.807 0.997 1.000 353 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(1), RB1(1), SP1(1) 570349 3 1 3 0 1 0 2 0 0 0 0.547 0.997 1.000 354 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK2(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), SHC1(1), SOS1(3), SYK(2), VAV1(4) 3715508 42 6 42 9 10 11 6 6 8 1 0.104 0.997 1.000 355 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 APAF1(3), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CRADD(2), GSN(4), LMNB1(1), LMNB2(1), MAP2K7(2), MAP3K1(3), MAPK8(1), MDM2(1), NFKBIA(2), NUMA1(3), PAK2(2), PRKCD(2), PRKDC(6), PSEN1(1), PSEN2(1), PTK2(3), RASA1(1), RB1(1), RELA(1), SPTAN1(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 5885065 58 15 55 14 13 9 15 6 14 1 0.192 0.997 1.000 356 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), EPX(4), ESCO1(4), ESCO2(1), GOT1(2), HPD(3), LPO(4), MPO(2), SH3GLB1(1), TPO(3) 2950561 34 5 34 10 15 4 5 5 5 0 0.240 0.997 1.000 357 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(3), DIAPH1(3), GSN(4), HRAS(1), ITGA1(4), MYLK(8), PIK3CA(1), PIK3R1(1), PTK2(3), ROCK1(2), SHC1(1), SRC(1), TLN1(7) 3111267 39 9 36 10 8 9 6 5 11 0 0.318 0.997 1.000 358 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), GCDH(2), HADHA(1), SH3GLB1(1) 2232521 14 4 14 7 2 3 2 3 4 0 0.865 0.997 1.000 359 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(2), AGTR2(1), CAMK2D(1), CDK5(1), GNA11(2), GNAI1(1), GNB1(1), HRAS(1), JAK2(2), MAPK8(1), MAPT(1), MYLK(8), PLCG1(1), SHC1(1), SOS1(3), STAT1(1), STAT3(1), STAT5A(1) 3499349 30 8 28 9 5 6 5 4 10 0 0.574 0.997 1.000 360 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(2), ARSE(1), CYP11B1(2), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), STS(2), SULT2A1(1), UGT1A1(2), UGT2B15(1), UGT2B4(1) 2348939 17 4 17 6 4 5 3 1 4 0 0.518 0.997 1.000 361 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(8), ATM(6), BUB1(1), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(4), CDC14A(3), CDC14B(1), CDC20(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(2), CDH1(1), CDK4(2), CHEK2(1), E2F3(3), E2F4(3), E2F5(2), EP300(4), ESPL1(3), GSK3B(1), HDAC4(2), HDAC5(2), HDAC6(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(2), PRKDC(6), RB1(1), RBL1(1), TBC1D8(2), TGFB1(1) 9238098 97 20 93 18 20 13 22 18 22 2 0.0428 0.997 1.000 362 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), APC(4), AXIN1(3), AXIN2(1), CTNNB1(6), DACT1(2), DKK2(1), DKK4(1), DVL1(4), GSK3A(1), GSK3B(1), LRP1(12), MVP(2), NKD1(3), PSEN1(1), SENP2(1), WIF1(1) 3496749 46 11 43 13 17 10 5 6 8 0 0.232 0.998 1.000 363 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 CYP1A2(2), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP3A7(3), HSD3B7(2), PLA2G3(2), PLA2G6(3), RDH11(2) 2060711 20 4 20 7 4 2 8 4 2 0 0.651 0.998 1.000 364 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(8), ATM(6), ATR(5), CCNA1(2), CCND1(1), CCNE1(1), CDC25A(2), CDK4(2), DHFR(1), GSK3B(1), RB1(1), TGFB1(1), TGFB2(2) 2480456 33 10 30 10 4 5 10 3 11 0 0.749 0.998 1.000 365 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 37 AARS(1), AARS2(6), CARS2(2), DARS(1), FARS2(2), FARSB(1), GARS(5), IARS(2), KARS(1), LARS2(2), MTFMT(2), NARS2(1), PARS2(1), QARS(1), RARS(1), RARS2(2), SARS2(1), TARS(2), VARS(1), VARS2(1), WARS(2) 4502142 38 12 35 9 8 6 10 5 9 0 0.403 0.998 1.000 366 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLAT(3), ENO1(1), FBP2(1), GAPDHS(1), GCK(1), GOT1(2), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), MDH2(1), PC(2), PCK1(2), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PKLR(1), TPI1(2) 3654857 33 4 33 8 9 9 6 4 5 0 0.0980 0.998 1.000 367 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(2), AOC2(1), AOC3(2), ESD(1) 517108 6 1 6 2 3 2 1 0 0 0 0.471 0.998 1.000 368 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT2(1), FUT6(1) 441507 3 1 3 1 3 0 0 0 0 0 0.595 0.998 1.000 369 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(2), CD33(1), CD5(1), IL12B(1), ITGAX(1), TLR2(1), TLR9(6) 1599821 15 2 15 6 5 4 1 4 1 0 0.623 0.998 1.000 370 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG7(2), GABARAPL1(1), IFNA10(1), IFNA16(1), PIK3C3(2), PIK3R4(3), PRKAA2(1), ULK1(2), ULK3(1) 1834852 15 3 15 4 3 3 1 5 3 0 0.445 0.998 1.000 371 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK1G(1), CAMK2D(1), CAMK4(2), ESRRA(1), HDAC5(2), MEF2A(1), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CC(1), YWHAH(1) 1762435 14 3 14 2 2 3 2 2 5 0 0.205 0.998 1.000 372 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(2), EP300(4), IKBKB(2), NFKBIA(2), RELA(1), TNFRSF1A(2), TNFRSF1B(2), TRADD(1) 1949524 17 6 17 6 3 3 6 2 3 0 0.658 0.998 1.000 373 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2M1(1), ARF1(1), BAD(1), BTK(1), EEA1(3), GSK3A(1), GSK3B(1), PFKL(1), PFKM(1), PFKP(1), PLCG1(1), PRKCE(1), PRKCZ(1) 2202973 17 4 17 2 3 7 2 2 3 0 0.0429 0.998 1.000 374 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT2(1), GCNT2(1), ST8SIA1(2) 538356 5 1 5 1 3 1 1 0 0 0 0.347 0.999 1.000 375 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(6), ACAT1(2), ACSS1(1), ACSS2(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), HIBCH(2), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1) 3412159 28 5 27 5 10 5 3 4 6 0 0.121 0.999 1.000 376 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(2), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), PIGW(1) 2070293 16 4 16 3 5 3 2 4 2 0 0.146 0.999 1.000 377 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 ABO(1), B3GALT1(1), B3GALT2(1), B3GALT4(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT2(1), FUT2(1), FUT4(1), FUT6(1), GCNT2(1), PIGB(1), PIGG(2), PIGL(2), PIGO(2), PIGP(1), PIGQ(3), PIGS(2), ST3GAL1(2), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(2), ST6GALNAC6(2), ST8SIA1(2), ST8SIA5(1), UGCG(1) 4095579 38 9 37 6 15 7 5 4 7 0 0.0118 0.999 1.000 378 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 17 CAMK2D(1), DAG1(2), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), PDE6C(1), TF(1) 2702244 22 4 22 7 8 2 5 2 5 0 0.576 0.999 1.000 379 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 HRAS(1), LCK(1), MAP2K4(2), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PIK3CA(1), PIK3R1(1), PLCG1(1), PPP3CA(1), PPP3CC(1), RASA1(1), RELA(1), SHC1(1), SOS1(3), VAV1(4), ZAP70(4) 4007593 43 6 43 8 9 11 7 6 9 1 0.0587 0.999 1.000 380 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 GOT1(2), LDHB(1) 588488 3 1 3 0 1 0 1 1 0 0 0.455 0.999 1.000 381 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD4(2), CREBBP(2), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4) 1982417 28 5 27 5 11 6 5 3 3 0 0.0664 0.999 1.000 382 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD4(2), CREBBP(2), CSK(1), GNAS(6), GNB1(1), LCK(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTPRC(2), ZAP70(4) 1982417 28 5 27 5 11 6 5 3 3 0 0.0664 0.999 1.000 383 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 30 ACP5(1), ALPI(4), ALPL(1), ALPP(4), ALPPL2(2), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), PON1(1) 2443726 33 6 32 10 12 4 7 3 7 0 0.296 0.999 1.000 384 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 ABP1(2), AOC2(1), AOC3(2), DDHD1(2), ESCO1(4), ESCO2(1), PLA1A(1), SH3GLB1(1) 2177920 14 5 14 6 5 4 0 3 2 0 0.637 0.999 1.000 385 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), DCT(4), GOT1(2), HGD(2), HPD(3), TPO(3), TYR(2) 2743392 35 6 35 13 15 5 6 4 5 0 0.372 0.999 1.000 386 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AGPAT3(3), AGPAT4(4), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DGAT1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), GK(2), GK2(3), GLB1(1), GPAM(3), LCT(3), LIPF(2), LIPG(3), LPL(2), PNLIP(1), PNLIPRP1(1), PPAP2B(2) 5006115 57 7 57 18 25 7 9 8 8 0 0.170 0.999 1.000 387 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(1), ACADS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), AUH(1), BCAT1(2), BCAT2(1), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), HIBCH(2), HMGCS2(1), HSD17B4(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 3716060 34 5 33 4 7 6 7 4 10 0 0.0299 0.999 1.000 388 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(1), CCKBR(2), CELSR1(3), CELSR2(4), CELSR3(10), CHRM2(3), CHRM3(2), EMR2(3), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(1), GPR132(1), GPR133(6), GPR143(1), GPR18(1), GPR56(1), GPR61(1), GPR77(1), GRPR(1), LGR6(1), LPHN2(4), LTB4R2(1), P2RY13(3), PTGFR(1), SMO(2), TAAR5(1), TSHR(3) 5547848 62 13 62 20 24 10 12 8 7 1 0.131 0.999 1.000 389 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), FBP2(1), FUK(1), GMPPA(4), HK1(2), HK2(2), HK3(2), HSD3B7(2), MTMR6(1), PFKFB1(2), PFKFB2(1), PFKFB4(2), PFKL(1), PFKM(1), PFKP(1), PGM2(1), PHPT1(1), PMM2(1), RDH11(2), TPI1(2), TSTA3(1) 3245551 33 8 33 9 10 6 11 3 3 0 0.180 0.999 1.000 390 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(1), ALDH3A1(1), CYP2C19(3), DHRS1(1), DHRS3(2), ESCO1(4), ESCO2(1), HADHA(1), SH3GLB1(1) 2661758 15 4 15 8 3 2 3 3 4 0 0.894 0.999 1.000 391 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(1), BTK(1), HRAS(1), MAP3K1(3), MAPK8(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), SHC1(1), SOS1(3), SYK(2), VAV1(4) 3304651 34 5 34 8 8 9 3 5 8 1 0.154 0.999 1.000 392 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), GCDH(2), HADHA(1) 671418 5 1 5 0 1 1 2 0 1 0 0.248 0.999 1.000 393 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 36 AKT1(2), CDC42(1), DUSP10(1), GCK(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K7(2), MAP3K9(2), MAPK10(1), MAPK7(4), MAPK8(1), MAPK9(1), MYEF2(1), NFATC3(2), NR2C2(1), PAPPA(2), SHC1(1) 4031209 38 10 37 10 10 9 5 6 8 0 0.252 0.999 1.000 394 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 8 CD4(2), LCK(1), PTPRC(2), ZAP70(4) 648747 9 1 9 2 2 2 1 2 2 0 0.366 0.999 1.000 395 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 DLG4(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), NOS1(5), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 2084964 30 5 30 10 10 5 6 6 3 0 0.417 0.999 1.000 396 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(1), HSD17B2(1), HSD17B4(2), HSD3B1(2) 696129 7 1 7 3 1 3 2 1 0 0 0.636 1.000 1.000 397 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 29 ARHGAP5(3), ARHGAP6(3), ARHGEF1(3), ARHGEF11(3), ARHGEF5(1), ARPC2(1), BAIAP2(1), DIAPH1(3), GSN(4), LIMK1(1), MYLK(8), PIP5K1B(2), ROCK1(2), SRC(1), TLN1(7), VCL(1) 3909069 44 10 41 13 10 9 9 6 10 0 0.393 1.000 1.000 398 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ACAT1(2), HADHA(1), HADHB(2) 718327 6 1 6 0 0 2 1 0 3 0 0.187 1.000 1.000 399 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2RL1(1), F2RL2(1), F2RL3(1), MAPK7(4), MAPK8(1), MYEF2(1), PLD2(2), PLD3(1), PTK2(3), RASAL1(2), SRC(1), TEC(2), VAV1(4) 2392343 27 2 27 7 8 8 4 2 4 1 0.137 1.000 1.000 400 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 9 ACP5(1), ENPP3(2), RFK(1), TYR(2) 723843 6 1 6 1 2 3 1 0 0 0 0.303 1.000 1.000 401 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(6), GNB1(1), PRKAR1A(1) 585170 11 3 10 2 5 3 2 1 0 0 0.259 1.000 1.000 402 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(2), CYP2A7(1), NAT2(1), XDH(4) 680285 10 2 10 5 5 1 0 2 2 0 0.761 1.000 1.000 403 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKBIA(2), PLCB1(1), RELA(1) 712970 5 2 5 2 0 1 2 1 1 0 0.774 1.000 1.000 404 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(1), CDC34(1), CUL1(1), FBXW7(3), RB1(1) 717348 7 2 7 3 1 3 1 2 0 0 0.716 1.000 1.000 405 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HADHA(1), HADHB(2), HSD17B4(2), PPT2(2) 731370 7 1 7 0 1 1 1 2 2 0 0.122 1.000 1.000 406 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(2), CPO(2), HBB(1) 702436 5 3 5 2 2 1 1 0 1 0 0.624 1.000 1.000 407 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(6), ACAT1(2), ACOT12(1), ACSS1(1), ACSS2(2), AKR1B1(1), ALDH1A3(1), ALDH3A1(1), DLAT(3), GLO1(1), GRHPR(1), HAGH(1), LDHB(1), MDH2(1), ME1(2), ME2(2), PC(2), PCK1(2), PCK2(3), PDHA1(1), PKLR(1) 4025805 40 6 40 11 12 13 2 3 9 1 0.176 1.000 1.000 408 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(2), ALDH18A1(1), ALDH1A3(1), ALDH3A1(1), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CPS1(4), SAT2(1) 2561750 15 2 15 4 6 3 3 1 1 1 0.307 1.000 1.000 409 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(3), PDHA1(1), SLC18A3(1) 613068 7 3 7 3 4 0 3 0 0 0 0.668 1.000 1.000 410 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), GNAI1(1), GNAQ(1), GNAS(6), GNB1(1), HRAS(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 3052937 37 7 36 8 13 10 4 4 6 0 0.0790 1.000 1.000 411 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 GNAQ(1), GNAS(6), GNB1(1), HRAS(1), LIMK1(1), NOX1(2), PLCB1(1), PTK2(3), ROCK2(1) 2127312 17 4 16 8 5 4 3 2 3 0 0.852 1.000 1.000 412 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(3), MEF2A(1), MEF2D(1), YWHAH(1) 684413 8 1 8 1 0 2 3 1 2 0 0.352 1.000 1.000 413 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSE(1), ASAH1(1), CERK(1), DEGS1(1), ENPP7(1), GAL3ST1(1), GALC(1), GLB1(1), LCT(3), NEU4(1), PPAP2B(2), SGMS1(1), SGPP1(1), SMPD3(1), SMPD4(1), SPHK1(1), SPTLC1(1), UGCG(1) 3028114 21 4 21 9 7 4 1 5 4 0 0.535 1.000 1.000 414 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(1), ALG10B(1), ALG12(2), ALG5(1), ALG9(2), B4GALT2(1), DDOST(1), DHDDS(1), DOLPP1(1), DPAGT1(2), GANAB(2), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), ST6GAL1(1) 3699321 27 7 26 6 8 7 3 4 5 0 0.187 1.000 1.000 415 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(8), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), ATM(6), ATR(5), BUB1(1), BUB1B(1), BUB3(1), CCNA1(2), CCNA2(3), CCNB2(1), CCND1(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CDC14A(3), CDC14B(1), CDC16(1), CDC20(1), CDC23(1), CDC25A(2), CDC25C(2), CDC6(1), CDC7(2), CDK4(2), CDK7(1), CHEK2(1), CREBBP(2), CUL1(1), E2F3(3), EP300(4), ESPL1(3), GSK3B(1), MAD1L1(1), MAD2L1(1), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PKMYT1(2), PRKDC(6), RB1(1), RBL1(1), RBL2(2), SKP1(1), SMC1A(1), SMC1B(1), TGFB1(1), TGFB2(2), YWHAE(2), YWHAH(1) 11329946 110 22 105 27 20 19 26 14 29 2 0.230 1.000 1.000 416 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 C1QA(1), C1QC(1), C1S(5), C3(5), C3AR1(2), C6(6), C7(3), C8A(3), C9(1), CD55(1), CD59(1), CFB(4), CFH(3), CFI(1), CR1(3), CR2(4), F10(4), F12(1), F13A1(1), F13B(1), F5(3), F8(2), FGA(3), FGB(4), FGG(1), KLKB1(1), MASP1(1), PLAT(1), PLAU(3), PLAUR(2), PROC(1), PROS1(1), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPINF2(1), SERPING1(1), TFPI(2), THBD(2), VWF(4) 7802629 90 18 86 19 17 18 22 15 17 1 0.0516 1.000 1.000 417 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(2), CD14(2), CD19(1), CD1A(1), CD1B(3), CD1C(1), CD1E(1), CD2(2), CD22(1), CD33(1), CD38(1), CD4(2), CD44(3), CD5(1), CD55(1), CD59(1), CR1(3), CR2(4), CSF1(1), CSF1R(3), CSF3R(1), DNTT(1), EPOR(2), FCGR1A(1), FLT3(3), GP9(2), HLA-DRB5(2), IL1B(1), IL1R2(2), IL2RA(1), IL6(2), IL7(1), IL7R(1), IL9R(1), ITGA1(4), ITGA3(1), ITGA5(1), ITGAM(1), ITGB3(1), KIT(3), MME(2), MS4A1(2), THPO(1), TPO(3) 6845830 75 16 74 21 13 14 14 17 16 1 0.270 1.000 1.000 418 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(2), BLVRA(2), CP(5), CPOX(1), FTMT(2), PPOX(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 3618032 21 6 21 6 2 8 1 3 7 0 0.433 1.000 1.000 419 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(2), LARS2(2), PDHA1(1) 856918 7 3 7 2 3 2 0 2 0 0 0.521 1.000 1.000 420 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(4), AXIN1(3), CCND1(1), CCND2(1), CCND3(1), CSNK1E(1), CTNNB1(6), DVL1(4), DVL2(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), MAPK10(1), MAPK9(1), PAFAH1B1(1), PLAU(3), PPP2R5C(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), SFRP4(1), TCF7(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT5B(1), WNT7A(1), WNT7B(2) 5198181 67 18 65 19 23 18 5 10 11 0 0.0813 1.000 1.000 421 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(3), ERBB4(6), PSEN1(1) 782094 10 2 10 2 1 5 1 2 1 0 0.317 1.000 1.000 422 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(4), ASAH1(1), CAMP(2), DAG1(2), DLG4(1), EPHB2(1), GNAI1(1), GNAQ(1), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), RYR1(22) 3996897 52 11 45 13 16 2 9 7 18 0 0.384 1.000 1.000 423 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 10 APAF1(3), BAD(1), BAK1(1), CASP8AP2(2) 878166 7 1 7 2 2 4 0 0 1 0 0.484 1.000 1.000 424 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT3(3), AGPAT4(4), CDIPT(1), CHAT(3), CPT1B(3), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), GPD1(1), LYPLA2(1), PAFAH1B1(1), PAFAH2(2), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLCB2(3), PLCG1(1), PLCG2(4), PPAP2B(2) 4382186 49 8 49 10 18 5 10 7 9 0 0.0589 1.000 1.000 425 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(3), BIRC2(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), GAS2(3), NFKBIA(2), RELA(1), SPTAN1(2), TNFRSF10B(2), TRADD(1), TRAF2(1) 2918040 23 4 23 7 7 5 4 2 5 0 0.346 1.000 1.000 426 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 37 APAF1(3), BAK1(1), BIRC2(1), CASP2(2), CASP7(1), CASP8(2), FAS(1), FASLG(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), PARP1(2), PRF1(3), RELA(1), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 3009114 33 9 32 11 7 5 10 4 7 0 0.586 1.000 1.000 427 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(6), CCNA1(2), CCND1(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDC25A(2), CDK4(2), CDK7(1), CREB3L1(1), CREB3L3(1), E2F3(3), E2F4(3), E2F5(2), GBA2(3), MCM2(3), MCM3(3), MCM4(1), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYT1(9), POLA2(1), POLE(7), POLE2(1), RB1(1), RBL1(1), RPA1(1), RPA2(1), RPA3(2), TFDP2(1), TNXB(8) 6524382 80 19 76 20 19 11 14 16 19 1 0.181 1.000 1.000 428 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NOX1(2), RELA(1), SOD1(1), XDH(4) 859903 8 1 8 7 2 2 2 1 1 0 0.978 1.000 1.000 429 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ANKRD1(1), ATF3(1), DUSP14(1), IFRD1(3), JUND(1), MYOG(2), WDR1(2) 846622 11 2 11 3 3 2 0 5 1 0 0.355 1.000 1.000 430 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 62 APAF1(3), BAD(1), BAK1(1), BIRC2(1), CASP1(2), CASP10(1), CASP2(2), CASP4(2), CASP7(1), CASP8(2), CHUK(1), FAS(1), FASLG(1), HELLS(4), IKBKB(2), IRF1(1), IRF3(1), IRF6(4), IRF7(1), MAP2K4(2), MAP3K1(3), MAPK10(1), MDM2(1), NFKBIA(2), NFKBIE(1), PRF1(3), RELA(1), TNFRSF10B(2), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1) 4673279 54 14 51 13 9 10 12 7 15 1 0.271 1.000 1.000 431 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 68 ACTN1(1), ACTN2(4), ACTN3(1), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(1), CDH1(1), CREBBP(2), CSNK2A1(2), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), EGFR(2), EP300(4), ERBB2(5), FARP2(1), FER(6), FGFR1(1), IGF1R(4), INSR(4), LEF1(2), LMO7(5), MAP3K7(2), MET(4), MLLT4(4), NLK(1), PARD3(3), PTPN6(4), PTPRB(8), PTPRF(6), PTPRJ(1), PTPRM(5), PVRL2(1), RAC2(1), SORBS1(1), SRC(1), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(1), TGFBR1(2), TGFBR2(4), TJP1(4), VCL(1), WASF1(1), WASF2(2), YES1(1) 9479565 126 20 121 25 32 26 20 23 23 2 0.00880 1.000 1.000 432 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(3), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GLUD2(1), GOT1(2), LAP3(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), PYCR2(1), RARS(1), RARS2(2) 3126095 48 8 48 10 12 9 13 6 7 1 0.0936 1.000 1.000 433 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), CAMK1G(1), FPR1(1), GNA15(1), GNB1(1), HRAS(1), MAP2K6(3), MAP3K1(3), NCF2(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), PAK1(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RELA(1) 3332326 35 7 33 11 6 7 11 4 7 0 0.560 1.000 1.000 434 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), CARM1(1), FTCD(2), HAL(1), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), PRPS1(1), UROC1(2) 3430693 24 4 24 9 7 8 6 1 2 0 0.426 1.000 1.000 435 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), AOX1(1), BCAT1(2), BCKDHA(2), BCKDHB(1), HADHA(1), HADHB(2), HIBADH(2), MCCC1(2), MCCC2(2), MCEE(1), MUT(2), OXCT1(1) 3100288 29 4 29 3 5 8 6 3 7 0 0.0212 1.000 1.000 436 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2) 875586 6 1 6 1 3 1 1 0 1 0 0.288 1.000 1.000 437 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 46 ADCY4(3), ADCY6(2), ADCY8(3), CACNA1A(7), CACNA1B(6), GNAS(6), GNB1(1), GNB3(1), GRM4(1), ITPR3(6), PLCB2(3), PRKACG(2), SCNN1A(2), SCNN1B(1), TAS1R1(5), TAS1R2(3), TAS1R3(1), TAS2R1(2), TAS2R10(1), TAS2R16(2), TAS2R3(1), TAS2R38(1), TAS2R41(1), TAS2R50(2), TAS2R60(1), TAS2R9(1), TRPM5(1) 4844540 66 16 60 15 20 9 13 6 18 0 0.0474 1.000 1.000 438 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(2), IFNAR2(2), MAPK8(1), RELA(1), TNFRSF11A(2) 959360 9 1 9 2 1 2 2 3 1 0 0.419 1.000 1.000 439 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(6), GNB1(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 851958 14 3 13 2 8 3 3 0 0 0 0.138 1.000 1.000 440 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 6 MBTPS1(1), SCAP(1) 889669 2 1 2 6 0 0 0 1 1 0 0.999 1.000 1.000 441 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 39 ALK(1), AR(2), ESR1(1), ESR2(1), ESRRA(1), HNF4A(1), NR0B1(1), NR1H3(2), NR1I2(1), NR2C2(1), NR2E1(2), NR2F2(2), NR2F6(1), NR3C1(2), NR4A1(1), NR4A2(3), PGR(3), PPARA(1), PPARD(1), RARB(1), RARG(2), ROR1(2), RORA(1), RORC(1) 3632183 35 6 35 11 9 7 6 6 7 0 0.278 1.000 1.000 442 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT2(1), HEXB(1), ST3GAL1(2), ST8SIA1(2) 928258 6 1 6 1 3 1 1 0 1 0 0.281 1.000 1.000 443 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(2), AGPAT3(3), AGPAT4(4), CDIPT(1), CHAT(3), CHPT1(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), ESCO1(4), ESCO2(1), ETNK2(1), GPAM(3), GPD1(1), LYPLA2(1), PCYT1B(1), PISD(1), PLA2G3(2), PLA2G6(3), PLD2(2), PPAP2B(2), PTDSS1(2), SH3GLB1(1) 5736042 52 11 52 16 18 6 9 8 11 0 0.320 1.000 1.000 444 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(5), ASH2L(2), C17orf79(1), CARM1(1), DOT1L(1), EED(2), EHMT1(3), EHMT2(2), EZH2(3), FBXO11(1), HCFC1(2), KDM6A(1), MEN1(2), MLL(2), MLL2(15), MLL3(15), MLL5(1), NSD1(3), OGT(1), PAXIP1(1), PPP1CA(1), PRDM2(5), PRDM7(1), PRDM9(3), PRMT6(1), PRMT8(1), SATB1(5), SETD1A(4), SETD2(3), SETD8(1), SETDB1(1), SUV39H2(2), SUV420H1(3), SUV420H2(2), WHSC1(2), WHSC1L1(1) 10285379 100 23 96 24 11 19 22 19 29 0 0.309 1.000 1.000 445 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 159 ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CCBP2(1), CCKAR(5), CCKBR(2), CCR1(1), CCR10(2), CCR4(2), CCR7(1), CCR9(1), CCRL1(1), CCRL2(2), CHML(3), CHRM2(3), CHRM3(2), CHRM5(3), CMKLR1(1), CXCR4(3), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHR(1), GALR1(2), GALR2(1), GPR173(1), GPR174(1), GPR3(1), GPR4(1), GPR77(1), GPR83(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), MC3R(2), MC5R(1), MLNR(1), MTNR1A(1), NMUR2(2), NPY1R(1), NPY2R(3), NPY5R(1), OPN1SW(1), OPN3(1), OPRD1(1), OPRL1(2), OPRM1(1), OR1C1(2), OR1Q1(1), OR8B8(2), OXTR(1), P2RY1(2), P2RY13(3), P2RY14(1), P2RY2(1), P2RY6(1), PTGDR(2), PTGFR(1), RGR(1), SSTR1(2), SSTR4(3), SUCNR1(1), TBXA2R(1), TRHR(1) 10296497 131 22 129 34 40 16 42 23 10 0 0.00745 1.000 1.000 446 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 112 ATP12A(3), ATP4A(6), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), COX4I2(2), COX7A2(1), COX7C(1), NDUFA10(2), NDUFA11(1), NDUFA4(1), NDUFA6(1), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB8(1), NDUFB9(2), NDUFS1(1), NDUFS6(1), NDUFS7(1), NDUFV1(1), NDUFV3(1), SDHA(3), TCIRG1(1), UQCRC2(1), UQCRFS1(1) 4775054 51 11 50 15 10 10 8 9 13 1 0.378 1.000 1.000 447 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(3), EGF(2), EGFR(2), HGS(2), TF(1) 1102888 10 1 10 1 1 4 2 2 1 0 0.128 1.000 1.000 448 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 32 AKT1(2), BCR(1), BTK(1), CD19(1), DAPP1(1), FLOT1(1), FLOT2(1), ITPR1(5), ITPR2(3), ITPR3(6), PDK1(1), PHF11(1), PIK3CA(1), PLCG2(4), PREX1(4), PTEN(1), PTPRC(2), RPS6KA1(1), RPS6KA2(1), SYK(2), TEC(2), VAV1(4) 4753696 46 7 46 13 16 8 5 9 7 1 0.214 1.000 1.000 449 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A3(1), ALDH3A1(1), HADHA(1) 1050345 3 1 3 2 2 0 1 0 0 0 0.854 1.000 1.000 450 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(3), BMPR2(1), BUB1(1), CDIPT(1), CDKL1(1), CLK1(3), CLK4(1), CSNK2A1(2), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPPL1(3), ITPKB(3), MAP3K10(3), OCRL(1), PAK4(1), PIK3C2A(4), PIK3C2B(10), PIK3CA(1), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCG1(1), PLCG2(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), PRKG1(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), STK11(1), TGFBR1(2) 9795681 97 18 97 29 37 13 12 17 18 0 0.210 1.000 1.000 451 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 34 ACTA1(2), ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), BCR(1), CAPN1(1), CAPNS1(3), CSK(1), HRAS(1), ITGA1(4), MAPK8(1), PTK2(3), ROCK1(2), SHC1(1), SOS1(3), SRC(1), TLN1(7), VCL(1), ZYX(1) 4018370 41 9 41 11 13 11 4 3 10 0 0.160 1.000 1.000 452 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), ASAH1(1), BRAF(1), DAG1(2), DRD2(1), EGFR(2), EPHB2(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), PIK3CB(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), SHC1(1), SOS1(3), SOS2(1), SRC(1), STAT3(1), TERF2IP(1) 5080553 45 10 45 10 10 6 6 10 13 0 0.215 1.000 1.000 453 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(1), BRAF(1), CACNA1A(7), GNA11(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GNAZ(2), GRIA1(1), GRID2(2), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(4), HRAS(1), IGF1R(4), ITPR1(5), ITPR2(3), ITPR3(6), NOS1(5), NOS3(6), NPR1(1), NPR2(1), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP2R1A(1), PPP2R1B(2), PRKG1(1), PRKG2(1), RYR1(22) 9391070 111 23 103 29 34 9 26 17 25 0 0.243 1.000 1.000 454 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(2), APAF1(3), ATM(6), BAD(1), BIRC2(1), CAPN1(1), CASP10(1), CASP7(1), CASP8(2), CFLAR(2), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IKBKB(2), IL1B(1), IL1RAP(2), IRAK4(1), NFKBIA(2), NTRK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 7180899 63 12 63 18 19 15 8 9 12 0 0.172 1.000 1.000 455 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 41 CSK(1), DAG1(2), EPHB2(1), FBXW7(3), GRAP2(1), ITK(1), ITPKB(3), LCK(1), NCK1(3), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLCG1(1), PTPRC(2), RASGRP1(2), RASGRP2(2), SOS1(3), SOS2(1), VAV1(4), ZAP70(4) 4370381 45 7 44 10 13 10 6 7 8 1 0.117 1.000 1.000 456 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1) 1143416 11 1 11 5 6 3 1 1 0 0 0.648 1.000 1.000 457 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH4A1(3), AMD1(1), AOC2(1), AOC3(2), ARG2(1), CKB(1), CKM(3), CKMT1A(1), CKMT2(2), CPS1(4), DAO(3), GOT1(2), NOS1(5), NOS3(6), OAT(2), P4HA1(3), P4HA2(1), P4HA3(1), PYCR1(1), RARS(1) 3843113 48 7 48 10 16 10 11 5 5 1 0.0387 1.000 1.000 458 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(2), BLNK(1), BTK(1), CARD11(5), CD19(1), CD22(1), CHUK(1), CR2(4), FCGR2B(1), GSK3B(1), HRAS(1), IFITM1(1), IKBKB(2), INPP5D(1), LILRB3(1), MALT1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPN6(4), RAC2(1), SYK(2), VAV1(4), VAV3(1) 6114494 72 16 70 20 16 20 7 10 18 1 0.143 1.000 1.000 459 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 15 ACP5(1), ENPP3(2), MTMR6(1), PHPT1(1), RFK(1), TYR(2) 1184012 8 1 8 3 2 4 2 0 0 0 0.615 1.000 1.000 460 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 89 CLK3(1), CLK4(1), COL2A1(3), CPSF1(4), CPSF2(4), CPSF3(2), CPSF4(1), CSTF2(1), CSTF3(2), DDX20(1), DHX15(2), DHX16(3), DHX38(1), DHX8(1), DHX9(3), DICER1(5), FUS(1), GIPC1(1), LOC440563(2), METTL3(1), NCBP2(1), NONO(1), PAPOLA(2), POLR2A(2), PPM1G(1), PRPF3(2), PRPF8(2), PTBP1(1), RBM5(2), RNGTT(2), SF3A2(1), SF3B5(1), SNRPB(1), SNRPN(2), SPOP(1), SRPK1(2), SRPK2(1), SRRM1(4), SUPT5H(2), U2AF1(1), XRN2(3) 8870892 75 21 74 19 18 11 10 14 21 1 0.317 1.000 1.000 461 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 AKT1(2), DAG1(2), DGKA(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), PAK1(2), PDE3A(7), PDE3B(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), RIPK3(2) 4169816 37 11 35 12 10 5 6 3 13 0 0.616 1.000 1.000 462 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 84 ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(1), AMH(1), AMHR2(5), BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BMPR1A(3), BMPR2(1), COMP(2), CREBBP(2), CUL1(1), E2F4(3), E2F5(2), EP300(4), GDF5(1), GDF6(1), GDF7(1), INHBC(1), LEFTY2(1), PPP2R1A(1), PPP2R1B(2), RBL1(1), RBL2(2), ROCK1(2), ROCK2(1), SKP1(1), SMAD7(1), SMAD9(1), SP1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), THBS1(1), THBS2(4), ZFYVE16(4), ZFYVE9(3) 8064473 76 11 75 20 19 15 14 15 13 0 0.166 1.000 1.000 463 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), PRKAA2(1), PRKAB1(1), PRKAB2(1) 1236763 7 1 7 0 0 3 0 1 3 0 0.0939 1.000 1.000 464 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 85 AKT1(2), CARD11(5), CBLB(1), CD4(2), CDC42(1), CDK4(2), CHUK(1), GRAP2(1), HRAS(1), IKBKB(2), ITK(1), LCK(1), MALT1(1), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIA(2), NFKBIE(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKCQ(2), PTPN6(4), PTPRC(2), RASGRP1(2), SOS1(3), SOS2(1), TEC(2), VAV1(4), VAV3(1), ZAP70(4) 8074641 91 15 88 27 24 23 10 11 22 1 0.183 1.000 1.000 465 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(4), AR(2), ASAH1(1), BRAF(1), CAMP(2), DAG1(2), EGFR(2), GNA11(2), GNA15(1), GNAI1(1), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), MAPK10(1), PHKA2(2), PIK3CA(1), PIK3CD(1), PIK3R1(1), SRC(1) 4656160 46 10 46 14 13 4 7 9 13 0 0.447 1.000 1.000 466 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(1), CD38(1), ENPP3(2), NADSYN1(3), NNT(4), NT5E(1), NT5M(1) 1254091 13 1 13 3 4 3 2 2 2 0 0.270 1.000 1.000 467 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 AK3(1), CAD(4), CTPS2(1), DPYD(4), DPYS(4), DUT(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), NME4(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(2), POLE(7), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), RRM1(1), RRM2B(1), TXNRD2(1), TYMS(1), UMPS(2), UPB1(2), UPP2(1) 6779395 63 12 62 18 17 11 11 13 11 0 0.252 1.000 1.000 468 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CD2(2), CD4(2), IL12B(1), JAK2(2), TYK2(1) 1248917 8 1 8 2 2 1 1 2 2 0 0.511 1.000 1.000 469 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(2), AGT(2), AKT1(2), CAMK1(1), CAMK1G(1), CAMK4(2), CREBBP(2), EDN1(1), ELSPBP1(1), FGF2(1), FKBP1A(1), GATA4(1), GSK3B(1), HAND2(1), HRAS(1), LIF(2), MAPK8(1), MYH2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PIK3CA(1), PIK3R1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 4392482 49 9 48 12 16 10 7 4 12 0 0.0961 1.000 1.000 470 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK8(1), RELA(1), TNFRSF13B(1), TNFRSF13C(1), TRAF2(1), TRAF5(1) 1263435 7 1 7 3 1 1 3 0 2 0 0.763 1.000 1.000 471 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(1), GALNT4(1), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), ST3GAL1(2) 1233267 9 1 9 4 2 3 3 0 1 0 0.657 1.000 1.000 472 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(1), HRAS(1), NFKBIA(2), PLCB1(1), RELA(1) 1259716 6 2 6 3 1 1 3 1 0 0 0.885 1.000 1.000 473 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), CASP8(2), CCL3(1), CD14(2), CD80(1), CD86(1), CHUK(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IKBKB(2), IKBKE(1), IL12B(1), IL1B(1), IL6(2), IRAK4(1), IRF3(1), IRF7(1), LY96(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), NFKBIA(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), RELA(1), STAT1(1), TBK1(1), TICAM1(1), TLR1(2), TLR2(1), TLR3(2), TLR5(2), TLR6(2), TLR8(1), TLR9(6) 7775663 75 15 73 20 15 16 18 8 18 0 0.161 1.000 1.000 474 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 AKT1(2), ARHGEF11(3), BTK(1), CDC42(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(6), LIMK1(1), MYLK(8), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PTEN(1), RACGAP1(2), ROCK1(2), ROCK2(1), WASF1(1) 5832760 59 13 57 19 15 10 11 9 14 0 0.458 1.000 1.000 475 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CD22(1), CR2(4), CSK(1), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPP5D(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP4K1(2), NFATC1(4), NFATC2(4), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTPRC(2), SHC1(1), SOS1(3), SOS2(1), SYK(2), VAV1(4) 6415944 67 12 67 18 20 17 5 8 16 1 0.0937 1.000 1.000 476 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 243 ACVR1B(2), ACVR2A(2), AMH(1), AMHR2(5), BMP2(1), BMP7(1), BMPR1A(3), BMPR2(1), CCL1(2), CCL21(1), CCL24(1), CCL27(1), CCL3(1), CCR1(1), CCR4(2), CCR7(1), CCR9(1), CSF1(1), CSF1R(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCR4(3), EDA(1), EDAR(2), EGF(2), EGFR(2), EPOR(2), FAS(1), FASLG(1), FLT1(2), FLT3(3), FLT4(8), GDF5(1), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(2), IFNK(1), IL10RA(1), IL12B(1), IL17RA(2), IL18RAP(1), IL1B(1), IL1R2(2), IL1RAP(2), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL6(2), IL6ST(2), IL7(1), IL7R(1), IL9R(1), INHBC(1), KDR(1), KIT(3), LIF(2), LIFR(4), MET(4), NGFR(1), OSMR(2), PDGFC(1), PDGFRA(8), PDGFRB(2), PF4V1(1), PLEKHO2(1), PRL(1), PRLR(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF10B(2), TNFRSF10C(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF12A(1), TNFRSF13B(1), TNFRSF13C(1), TNFRSF19(3), TNFRSF1A(2), TNFRSF1B(2), TNFSF14(1), TNFSF8(3), TPO(3), TSLP(1), VEGFB(2), XCR1(1) 14930144 168 31 162 34 44 38 30 28 28 0 0.000248 1.000 1.000 477 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 32 SNAP23(1), SNAP29(3), STX3(1), STX4(2), VTI1A(1) 1303697 8 1 8 7 5 0 0 1 2 0 0.946 1.000 1.000 478 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM17(3), ATP6AP1(1), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1F(1), CDC42(1), CHUK(1), CSK(1), EGFR(2), F11R(1), GIT1(2), IGSF5(1), IKBKB(2), JAM2(1), MAP2K4(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MET(4), NFKBIA(2), NOD1(3), PAK1(2), PLCG1(1), PLCG2(4), PTPRZ1(2), RELA(1), SRC(1), TCIRG1(1), TJP1(4) 6005361 57 9 56 16 8 14 14 11 10 0 0.279 1.000 1.000 479 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 BAD(1), CABIN1(2), CAMK4(2), CREBBP(2), CSNK2A1(2), EGR3(1), EP300(4), FCER1A(1), GATA3(1), GATA4(1), GSK3A(1), GSK3B(1), HRAS(1), IL1B(1), IL2RA(1), IL6(2), ITK(1), KPNA5(1), MAP2K7(2), MAPK8(1), MAPK9(1), MEF2A(1), MEF2D(1), MYF5(2), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NFKBIE(1), NUP214(4), OPRD1(1), P2RX7(1), PAK1(2), PPP3CC(1), PTPRC(2), RELA(1), SLA(1), SP1(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(4), VAV3(1) 7617812 76 16 75 24 24 18 10 7 16 1 0.282 1.000 1.000 480 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 81 ABL1(8), ABL2(1), AKT1(2), ARAF(1), BAD(1), BRAF(1), CAMK2D(1), CBLB(1), CRK(1), EGF(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GSK3B(1), HRAS(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK9(1), NCK1(3), NCK2(2), NRG1(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), SHC1(1), SHC2(2), SHC4(2), SOS1(3), SOS2(1), SRC(1), STAT5A(1), STAT5B(1) 8608139 91 16 89 23 24 21 13 10 23 0 0.0844 1.000 1.000 481 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(2), ABCA10(1), ABCA12(9), ABCA13(8), ABCA2(5), ABCA3(4), ABCA4(5), ABCA5(3), ABCA6(3), ABCA7(3), ABCA8(6), ABCA9(7), ABCB1(2), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(4), ABCB6(1), ABCC10(1), ABCC11(2), ABCC3(2), ABCC5(3), ABCC6(1), ABCC9(1), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(3), CFTR(2), TAP1(1) 9749576 94 16 92 29 19 22 16 21 16 0 0.183 1.000 1.000 482 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACADS(1), ACSL1(1), ACSL3(3), CPT2(1), HADHA(1), SCP2(1) 1447120 9 1 9 0 3 3 2 0 1 0 0.0474 1.000 1.000 483 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(3), CARM1(1), CCND1(1), CREBBP(2), EP300(4), ERCC3(4), ESR1(1), GRIP1(1), GTF2F1(2), HDAC4(2), HDAC5(2), HDAC6(1), NCOR2(5), NR0B1(1), NRIP1(1), POLR2A(2), TBP(1) 4074998 34 10 32 12 7 8 4 3 12 0 0.695 1.000 1.000 484 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), AKR1C3(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2F1(1), CYP2S1(2), CYP3A7(3), EPHX1(2), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), MGST2(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 4949750 51 7 50 16 13 13 11 6 8 0 0.289 1.000 1.000 485 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(3), GNAS(6), PLCE1(4), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RAP2B(1) 1309940 20 4 19 4 8 3 4 5 0 0 0.205 1.000 1.000 486 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(1), BMP4(2), BMP5(2), BMP7(1), BMP8B(1), BTRC(1), CSNK1A1L(2), CSNK1D(1), CSNK1E(1), CSNK1G3(3), DHH(2), FBXW11(2), GLI1(4), GLI2(2), GLI3(6), GSK3B(1), HHIP(3), LRP2(2), PRKACG(2), PTCH1(3), PTCH2(4), SMO(2), STK36(1), SUFU(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1), ZIC2(2) 5341938 64 17 62 22 23 11 13 7 10 0 0.452 1.000 1.000 487 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 DPEP1(1), LTA4H(1), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1) 1318200 10 2 10 8 5 0 2 1 2 0 0.959 1.000 1.000 488 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(6), GNB1(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1) 1343789 19 3 18 2 8 5 3 1 2 0 0.0356 1.000 1.000 489 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), HSD17B4(2), HSD3B7(2), NSD1(3), OGDH(5), OGDHL(1), PLOD1(1), PLOD2(1), RDH11(2), SETD1A(4), SETDB1(1), SHMT1(1), SHMT2(3), SUV39H2(2) 5035064 42 11 38 14 10 6 8 4 14 0 0.652 1.000 1.000 490 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), HLA-A(3), HRAS(1), ICAM1(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(2), ITGAL(2), ITGB2(1), KIR2DL1(1), KIR3DL2(3), KLRC1(1), KLRC2(2), LCK(1), NCR1(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), PAK1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRF1(3), PTPN6(4), RAC2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(3), SOS2(1), SYK(2), TNFRSF10B(2), TNFRSF10C(1), VAV1(4), VAV3(1), ZAP70(4) 9332162 96 17 92 26 25 20 10 15 25 1 0.115 1.000 1.000 491 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CSNK1D(1), DRD1(2), DRD2(1), EGF(2), EGFR(2), GNA11(2), GNAI1(1), GNAI2(1), GNAQ(1), GNAS(6), GRM5(4), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(4), HRAS(1), HTR2A(1), HTR2B(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP3K2(2), MAPK7(4), NPR1(1), NPR2(1), PDGFC(1), PDGFRA(8), PDGFRB(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), PRKG1(1), PRKG2(1), SOS1(3), SOS2(1), SRC(1), TJP1(4), TUBA1A(2), TUBA1C(1), TUBA3C(1), TUBA3D(2), TUBA3E(1), TUBA8(2), TUBAL3(1), TUBB1(3), TUBB2B(2), TUBB3(1), TUBB6(1) 11256982 129 20 124 30 42 22 22 21 22 0 0.00969 1.000 1.000 492 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADSL(1), ADSS(1), AK2(1), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ATP5A1(1), ATP5B(1), ATP5C1(1), ATP5F1(1), ATP5G3(2), ENPP3(2), ENTPD2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAICS(2), PAPSS1(2), PAPSS2(3), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE6C(1), PDE7B(1), PDE8A(1), PFAS(5), PKLR(1), POLD1(1), POLD2(1), POLE(7), POLG(5), POLL(3), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(2), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1) 11013155 110 17 109 28 35 24 18 13 18 2 0.0319 1.000 1.000 493 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1) 1571953 12 2 12 5 0 4 5 2 1 0 0.766 1.000 1.000 494 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 16 CHUK(1), IKBKB(2), MAP3K1(3), MAPK8(1), NFKBIA(2), RELA(1), TRAF2(1) 1605781 11 2 11 3 1 2 4 2 2 0 0.583 1.000 1.000 495 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(2), ILVBL(2), LARS2(2), PDHA1(1), VARS(1), VARS2(1) 1604132 12 3 12 4 5 3 1 2 1 0 0.587 1.000 1.000 496 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2A(1), ENPP3(2), GAA(1), GANAB(2), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), PGM1(1), PGM3(1), PYGB(2), PYGM(2), SI(2), UGDH(2), UGT1A1(2), UGT2B15(1), UGT2B4(1) 4906708 41 10 38 13 9 10 8 3 11 0 0.469 1.000 1.000 497 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), ME2(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2) 1559796 20 2 20 3 1 6 8 3 2 0 0.105 1.000 1.000 498 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(1), ACADL(1), ACOX2(1), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), APOA5(1), CPT1B(3), CPT1C(2), CPT2(1), CYP27A1(1), CYP4A22(1), CYP7A1(2), CYP8B1(1), FABP4(1), GK(2), GK2(3), HMGCS2(1), LPL(2), ME1(2), MMP1(1), NR1H3(2), PCK1(2), PCK2(3), PLTP(1), PPARA(1), PPARD(1), SCP2(1), SLC27A1(2), SLC27A4(1), SLC27A5(2), SORBS1(1), UBC(1) 5504739 51 7 51 12 13 15 10 5 7 1 0.0304 1.000 1.000 499 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(4), ACTN3(1), BCAR1(2), CSK(1), CTNNA1(3), CTNNA2(3), CTNNB1(6), PTK2(3), SRC(1), VCL(1) 1683706 26 3 26 6 11 8 1 4 2 0 0.0693 1.000 1.000 500 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 21 POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1) 1771137 10 2 10 6 5 2 1 1 1 0 0.835 1.000 1.000 501 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP2(1), GOT1(2), GPT(1), GPT2(2), MDH2(1), ME1(2), PGK1(2), PKLR(1), RPE(2), TKT(1), TPI1(2) 1740531 18 2 18 3 1 5 8 2 2 0 0.161 1.000 1.000 502 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CYP27A1(1), CYP7A1(2), HADHB(2) 1905735 17 3 17 8 6 4 3 2 2 0 0.740 1.000 1.000 503 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(8), ACTN1(1), AKT1(2), ARHGEF6(1), ARHGEF7(2), BCAR1(2), BRAF(1), CDC42(1), CRK(1), CSE1L(1), DOCK1(2), EPHB2(1), GRB7(1), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGB3BP(1), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MRAS(2), MYLK(8), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PIK3CA(1), PIK3CB(1), PKLR(1), PLCG1(1), PLCG2(4), PTEN(1), PTK2(3), ROCK1(2), ROCK2(1), SHC1(1), SOS1(3), SOS2(1), SRC(1), TERF2IP(1), TLN1(7), TLN2(1), ZYX(1) 10418886 99 16 95 28 21 19 17 19 23 0 0.246 1.000 1.000 504 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(2), MAP3K1(3), NFKBIA(2), RELA(1), TNFAIP3(1), TNFRSF1B(2), TRAF2(1) 1943717 15 3 15 7 1 4 7 2 1 0 0.815 1.000 1.000 505 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 65 RPL10A(1), RPL10L(1), RPL18A(1), RPL22L1(1), RPL24(1), RPL35(1), RPL3L(2), RPS11(2), RPS28(1) 1885528 11 2 11 3 5 0 2 0 4 0 0.621 1.000 1.000 506 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2RL3(1), GNAI1(1), GNB1(1), HRAS(1), ITGA1(4), PLCB1(1), PTK2(3), SRC(1), SYK(2), TBXAS1(1) 2102026 16 1 16 5 4 4 2 4 2 0 0.556 1.000 1.000 507 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(2), CHUK(1), CRADD(2), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP3K1(3), MAP4K2(2), MAPK8(1), NFKBIA(2), RELA(1), TNFRSF1A(2), TRADD(1), TRAF2(1) 2120966 26 3 25 6 7 4 9 3 3 0 0.215 1.000 1.000 508 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(2), BCAR1(2), CAPN1(1), CAPN11(1), CAPN3(2), CAPN5(2), CAPN7(1), CAPNS1(3), CDC42(1), CRK(1), CSK(1), DOCK1(2), GIT2(1), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAL(2), ITGAM(1), ITGAV(3), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB8(3), MAP2K6(3), MAPK10(1), MAPK12(1), MAPK4(1), MAPK7(4), MYLK2(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PIK3R2(2), PTK2(3), RAC2(1), RAP1B(1), ROCK1(2), ROCK2(1), SDCCAG8(1), SEPP1(1), SHC1(1), SORBS1(1), SOS1(3), SRC(1), TLN1(7), TNS1(5), VAV3(1), VCL(1), ZYX(1) 11519474 107 20 102 27 22 24 23 14 24 0 0.0487 1.000 1.000 509 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADSL(1), ADSS(1), AK2(1), AK7(3), ALLC(2), AMPD1(2), AMPD3(1), ATIC(1), ENPP3(2), ENTPD2(1), ENTPD4(2), ENTPD5(1), ENTPD6(3), ENTPD8(1), GMPR(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NME4(1), NPR1(1), NPR2(1), NT5C2(2), NT5C3(1), NT5E(1), NT5M(1), NUDT9(2), PAICS(2), PAPSS1(2), PAPSS2(3), PDE10A(5), PDE11A(1), PDE2A(1), PDE3B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE5A(3), PDE7B(1), PDE8A(1), PDE8B(1), PFAS(5), PKLR(1), PNPT1(2), POLA1(1), POLA2(1), POLD1(1), POLD2(1), POLD3(2), POLE(7), POLE2(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), PPAT(2), PRPS1(1), PRPS1L1(1), RRM1(1), RRM2B(1), XDH(4) 13942204 134 19 131 34 45 24 18 24 21 2 0.0250 1.000 1.000 510 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(1), ACAD9(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), BAAT(1), CYP27A1(1), CYP7A1(2), HADHB(2), HSD3B7(2), RDH11(2), SLC27A5(2), SOAT1(1) 2648531 26 4 26 9 9 6 6 3 2 0 0.434 1.000 1.000 511 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADL(1), ACADSB(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), ALDH6A1(1), HADHA(1), LDHB(1), MCEE(1), MUT(2), SUCLA2(1), SUCLG1(1) 2847780 20 1 20 2 4 5 3 5 3 0 0.0577 1.000 1.000 512 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), OGT(1), ST3GAL1(2) 2777876 20 2 20 9 5 5 4 3 3 0 0.711 1.000 1.000 513 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(1), CAPNS1(3), EGF(2), EGFR(2), HRAS(1), ITGA1(4), MYLK(8), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PTK2(3), TLN1(7) 2850602 39 6 38 10 12 11 5 4 7 0 0.102 1.000 1.000 514 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), ARHGAP5(3), BAD(1), BCAR1(2), BIRC2(1), BRAF(1), CCND1(1), CCND2(1), CCND3(1), CDC42(1), CHAD(1), COL11A1(7), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(6), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), CRK(1), CTNNB1(6), DIAPH1(3), DOCK1(2), EGF(2), EGFR(2), ERBB2(5), FARP2(1), FLNA(5), FLNB(3), FLNC(7), FLT1(2), FN1(5), GSK3B(1), HRAS(1), IBSP(2), IGF1R(4), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB8(3), KDR(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(3), LAMC1(1), LAMC3(2), MAPK10(1), MAPK8(1), MAPK9(1), MET(4), MYLK(8), MYLK2(3), MYLPF(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARVB(2), PARVG(1), PDGFC(1), PDGFRA(8), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP5K1C(1), PPP1CA(1), PTEN(1), PTK2(3), RAC2(1), RAP1B(1), RELN(8), ROCK1(2), ROCK2(1), SHC1(1), SHC2(2), SHC4(2), SOS1(3), SOS2(1), SRC(1), THBS1(1), THBS2(4), TLN1(7), TLN2(1), TNC(9), TNN(1), TNR(5), TNXB(8), VAV1(4), VAV3(1), VCL(1), VEGFB(2), VWF(4), ZYX(1) 31941587 344 40 331 93 87 70 56 55 72 4 0.00965 1.000 1.000 515 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 239 ACVR1B(2), ACVR1C(1), AKT1(2), ARRB1(1), ARRB2(2), BDNF(1), BRAF(1), CACNA1A(7), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CACNA2D1(1), CACNA2D3(2), CACNA2D4(1), CACNB1(1), CACNB2(4), CACNG1(1), CACNG3(1), CACNG5(1), CD14(2), CDC42(1), CHUK(1), CRK(1), DUSP10(1), DUSP14(1), DUSP16(1), DUSP2(1), DUSP7(2), EGF(2), EGFR(2), FAS(1), FASLG(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(1), FLNA(5), FLNB(3), FLNC(7), HRAS(1), IKBKB(2), IL1B(1), IL1R2(2), JUND(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K7(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(1), MAPT(1), MAX(2), MRAS(2), NF1(2), NFATC2(4), NFATC4(4), NLK(1), NR4A1(1), NTF3(2), NTRK1(2), NTRK2(2), PAK1(2), PAK2(2), PDGFRA(8), PDGFRB(2), PLA2G3(2), PLA2G6(3), PPP3CA(1), PPP3CC(1), PPP5C(1), PRKACG(2), RAC2(1), RAP1B(1), RAPGEF2(3), RASA1(1), RASA2(1), RASGRF2(1), RASGRP1(2), RASGRP2(2), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SOS1(3), SOS2(1), STK4(2), STMN1(1), TAOK1(2), TGFB1(1), TGFB2(2), TGFBR1(2), TGFBR2(4), TNFRSF1A(2), TRAF2(1) 24328592 248 37 238 75 71 43 37 38 55 4 0.124 1.000 1.000 516 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 CHAD(1), COL11A1(7), COL11A2(2), COL17A1(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(6), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), COMP(2), DES(1), DSC1(2), DSC2(3), DSC3(4), DSG1(2), DSG2(1), DSG4(2), FN1(5), GJA4(1), GJA8(2), GJB1(1), GJB4(1), GJB6(1), GJC1(1), GJC2(2), GJC3(1), GJD4(2), IBSP(2), INA(3), ITGB4(7), KRT1(3), KRT12(3), KRT15(3), KRT16(1), KRT17(2), KRT2(4), KRT20(1), KRT27(1), KRT3(2), KRT31(2), KRT33A(1), KRT34(2), KRT37(1), KRT38(1), KRT39(2), KRT4(1), KRT40(1), KRT6A(2), KRT7(2), KRT73(2), KRT74(1), KRT75(1), KRT76(1), KRT77(2), KRT79(2), KRT82(1), KRT83(3), KRT85(1), KRT86(1), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(3), LAMC1(1), LAMC3(2), LMNB1(1), LMNB2(1), NES(6), PRPH(1), RELN(8), THBS1(1), THBS2(4), TNC(9), TNN(1), TNR(5), TNXB(8), VWF(4) 21464114 258 36 250 74 69 45 44 40 57 3 0.0763 1.000 1.000 517 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 165 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY7(2), ADCY8(3), ADCY9(2), ADORA2A(1), ADRA1A(1), ATP2A1(3), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), AVPR1B(1), CACNA1A(7), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1F(1), CACNA1G(5), CACNA1H(1), CACNA1I(5), CACNA1S(4), CALML6(1), CAMK2D(1), CAMK4(2), CCKAR(5), CCKBR(2), CD38(1), CHRM2(3), CHRM3(2), CHRM5(3), CYSLTR2(1), DRD1(2), EDNRB(2), EGFR(2), ERBB2(5), ERBB3(3), ERBB4(6), GNA11(2), GNA15(1), GNAQ(1), GNAS(6), GRIN2A(4), GRIN2C(5), GRIN2D(4), GRM5(4), GRPR(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), LTB4R2(1), MYLK(8), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), PDE1B(1), PDGFRA(8), PDGFRB(2), PHKA2(2), PHKB(2), PHKG1(2), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD3(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PRKACG(2), PTGFR(1), RYR1(22), RYR2(8), RYR3(14), SLC25A4(1), SLC8A3(2), SPHK1(1), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TNNC1(2), TNNC2(1), TRHR(1), TRPC1(2), VDAC1(1) 23177417 308 34 289 94 87 37 70 55 55 4 0.0998 1.000 1.000 518 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 123 ABL1(8), ABLIM1(4), ABLIM2(2), ABLIM3(2), ARHGEF12(4), CDC42(1), CDK5(1), CXCR4(3), DCC(2), DPYSL2(1), DPYSL5(2), EFNA1(1), EPHA1(2), EPHA2(4), EPHA4(2), EPHA5(4), EPHA6(2), EPHA7(1), EPHA8(5), EPHB2(1), EPHB3(2), EPHB4(3), EPHB6(3), GNAI1(1), GNAI2(1), GSK3B(1), HRAS(1), L1CAM(1), LIMK1(1), LIMK2(1), LRRC4C(1), MET(4), NCK1(3), NCK2(2), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NGEF(1), NRP1(1), NTNG1(1), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PLXNA1(4), PLXNA2(6), PLXNA3(7), PLXNB1(4), PLXNB2(3), PLXNB3(5), PLXNC1(1), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), RASA1(1), RGS3(1), RHOD(1), RND1(1), ROBO1(5), ROBO2(3), ROBO3(5), ROCK1(2), ROCK2(1), SEMA3A(1), SEMA3B(1), SEMA3C(1), SEMA3D(4), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(3), SEMA4G(2), SEMA5A(2), SEMA5B(3), SEMA6A(2), SEMA6C(2), SEMA7A(1), SLIT1(5), SLIT2(2), SLIT3(4), SRGAP1(2), SRGAP3(6), UNC5A(3), UNC5B(1), UNC5C(3), UNC5D(4) 16776583 213 33 207 70 63 40 33 31 46 0 0.237 1.000 1.000 519 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 197 ABI2(1), ACTN1(1), ACTN2(4), ACTN3(1), APC(4), APC2(1), ARAF(1), ARHGEF1(3), ARHGEF12(4), ARHGEF6(1), ARHGEF7(2), ARPC2(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(2), BRAF(1), CD14(2), CDC42(1), CHRM2(3), CHRM3(2), CHRM5(3), CRK(1), CSK(1), CYFIP2(1), DIAPH1(3), DIAPH2(1), DIAPH3(2), DOCK1(2), EGF(2), EGFR(2), FGD1(1), FGF12(1), FGF2(1), FGF23(1), FGF5(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(1), FN1(5), GIT1(2), GSN(4), HRAS(1), IQGAP2(1), IQGAP3(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAD(1), ITGAE(5), ITGAL(2), ITGAM(1), ITGAV(3), ITGAX(1), ITGB2(1), ITGB3(1), ITGB4(7), ITGB5(3), ITGB8(3), LIMK1(1), LIMK2(1), MRAS(2), MYH10(8), MYH14(3), MYLK(8), MYLK2(3), MYLPF(1), NCKAP1(4), NCKAP1L(3), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PDGFRA(8), PDGFRB(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PPP1CA(1), PTK2(3), RAC2(1), RDX(2), ROCK1(2), ROCK2(1), SOS1(3), SOS2(1), SSH1(2), SSH2(1), SSH3(1), TIAM1(2), VAV1(4), VAV3(1), VCL(1), WASF1(1), WASF2(2) 23312183 218 33 205 74 51 40 39 30 56 2 0.536 1.000 1.000 520 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(2), CD44(3), CHAD(1), COL11A1(7), COL11A2(2), COL1A2(3), COL2A1(3), COL3A1(2), COL4A1(3), COL4A2(5), COL4A4(4), COL4A6(3), COL5A1(14), COL5A2(6), COL5A3(4), COL6A1(1), COL6A2(4), COL6A3(6), COL6A6(2), DAG1(2), FN1(5), FNDC1(5), GP6(1), GP9(2), HMMR(2), HSPG2(1), IBSP(2), ITGA1(4), ITGA11(1), ITGA3(1), ITGA5(1), ITGA7(3), ITGA8(1), ITGAV(3), ITGB3(1), ITGB4(7), ITGB5(3), ITGB8(3), LAMA1(8), LAMA2(6), LAMA3(1), LAMA4(3), LAMA5(6), LAMB1(5), LAMB2(4), LAMB3(2), LAMB4(3), LAMC1(1), LAMC3(2), RELN(8), SDC3(1), SDC4(2), SV2A(2), SV2C(1), THBS1(1), THBS2(4), TNC(9), TNN(1), TNR(5), TNXB(8), VWF(4) 19456320 210 31 204 57 53 40 39 33 42 3 0.0596 1.000 1.000 521 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADRA1A(1), ANXA6(2), ARRB1(1), ARRB2(2), ATP1A4(3), ATP1B3(1), ATP2A2(3), ATP2B1(4), ATP2B2(1), ATP2B3(2), CACNA1A(7), CACNA1B(6), CACNA1C(6), CACNA1D(8), CACNA1E(6), CACNA1S(4), CACNB1(1), CAMK1(1), CAMK2D(1), CAMK4(2), CASQ1(1), CHRM2(3), CHRM3(2), CHRM5(3), GJA4(1), GJB1(1), GJB4(1), GJB6(1), GNA11(2), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(2), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(2), ITPR1(5), ITPR2(3), ITPR3(6), KCNJ5(1), MIB1(1), PLCB3(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(22), RYR2(8), RYR3(14), SLC8A3(2), YWHAH(1) 16297932 198 29 185 70 56 32 37 27 42 4 0.438 1.000 1.000 522 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 140 APC(4), APC2(1), AXIN1(3), AXIN2(1), BTRC(1), CAMK2D(1), CCND1(1), CCND2(1), CCND3(1), CHD8(5), CREBBP(2), CSNK1A1L(2), CSNK1E(1), CSNK2A1(2), CTBP2(2), CTNNB1(6), CUL1(1), DAAM1(5), DAAM2(4), DKK2(1), DKK4(1), DVL1(4), DVL2(2), EP300(4), FBXW11(2), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GSK3B(1), LEF1(2), LRP5(5), LRP6(3), MAP3K7(2), MAPK10(1), MAPK8(1), MAPK9(1), MMP7(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NKD1(3), NLK(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPARD(1), PPP2R1A(1), PPP2R1B(2), PPP3CA(1), PPP3CC(1), PRICKLE1(3), PRICKLE2(4), PRKACG(2), PSEN1(1), RAC2(1), ROCK1(2), ROCK2(1), SENP2(1), SFRP4(1), SKP1(1), TCF7(1), TCF7L1(1), TCF7L2(1), VANGL1(1), WIF1(1), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1) 13602211 153 26 151 47 46 32 18 30 27 0 0.0813 1.000 1.000 523 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(2), ACTA2(1), ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), ADM(1), ARRB1(1), ARRB2(2), ATF1(1), ATF3(1), ATP2A2(3), CALCA(1), CAMK2D(1), CORIN(2), DGKZ(3), ETS2(2), GABPA(2), GBA2(3), GNAQ(1), GNB1(1), GNB3(1), GNB4(1), GNB5(1), GRK6(2), GUCA2B(1), GUCY1A3(1), IGFBP4(1), IL1B(1), IL6(2), ITPR1(5), ITPR2(3), ITPR3(6), MAFF(1), MIB1(1), MYLK2(3), NOS1(5), NOS3(6), OXTR(1), PDE4D(1), PLCB3(2), PLCG1(1), PLCG2(4), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), PRKCZ(1), RGS1(1), RGS10(1), RGS17(1), RGS3(1), RGS7(2), RGS9(1), RYR1(22), RYR2(8), RYR3(14), SP1(1), TNXB(8), YWHAH(1) 15109574 176 26 164 61 50 23 36 27 38 2 0.445 1.000 1.000 524 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 232 ADORA2A(1), ADORA3(1), ADRA1A(1), ADRA2A(1), ADRA2B(1), ADRA2C(2), AGTR2(1), AVPR1B(1), AVPR2(1), C3AR1(2), CALCR(1), CCKAR(5), CCKBR(2), CGA(1), CHRM2(3), CHRM3(2), CHRM5(3), CRHR2(1), CTSG(1), CYSLTR2(1), DRD1(2), DRD2(1), EDNRB(2), F2RL1(1), F2RL2(1), F2RL3(1), FPR1(1), FSHB(1), FSHR(1), GABBR1(5), GABBR2(1), GABRA4(5), GABRA5(3), GABRA6(1), GABRB1(2), GABRB3(3), GABRD(1), GABRE(1), GABRG2(1), GABRG3(1), GABRQ(1), GALR1(2), GALR2(1), GHR(1), GHRHR(1), GLP2R(3), GLRA2(2), GNRHR(1), GPR83(2), GRIA1(1), GRID1(5), GRID2(2), GRIK2(2), GRIK3(1), GRIK5(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRIN3A(3), GRIN3B(2), GRM2(2), GRM3(2), GRM4(1), GRM5(4), GRM6(4), GRM7(4), GRM8(2), GRPR(1), HCRTR1(1), HCRTR2(3), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1), LTB4R(3), LTB4R2(1), MC2R(2), MC3R(2), MC5R(1), MCHR1(1), MLNR(1), MTNR1A(1), NMUR2(2), NPBWR1(1), NPFFR2(1), NPY1R(1), NPY2R(3), NPY5R(1), NR3C1(2), OPRD1(1), OPRL1(2), OPRM1(1), OXTR(1), P2RX2(1), P2RX5(1), P2RX7(1), P2RY1(2), P2RY13(3), P2RY14(1), P2RY2(1), P2RY4(1), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(2), PRSS1(2), PTGDR(2), PTGFR(1), RXFP1(1), RXFP2(2), SSTR1(2), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(1), TAAR5(1), TAAR6(2), TAAR8(2), TACR1(2), TACR2(1), TACR3(1), TBXA2R(1), TRHR(1), TRPV1(2), TSHR(3), UTS2R(1), VIPR1(1), VIPR2(1) 18672434 236 25 230 70 71 37 56 40 31 1 0.0148 1.000 1.000 525 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTN1(1), ACTN2(4), ACTN3(1), AKT1(2), AMOTL1(2), ASH1L(5), CDC42(1), CDK4(2), CGN(1), CLDN17(2), CLDN3(1), CLDN9(1), CSNK2A1(2), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), EPB41L1(2), EPB41L2(4), EPB41L3(2), EXOC3(1), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), HRAS(1), IGSF5(1), JAM2(1), LLGL1(4), LLGL2(3), MAGI1(1), MAGI2(6), MAGI3(1), MLLT4(4), MPDZ(2), MRAS(2), MYH1(4), MYH10(8), MYH11(5), MYH13(1), MYH14(3), MYH15(4), MYH2(2), MYH3(1), MYH4(4), MYH6(5), MYH7(4), MYH7B(7), MYH8(3), MYLPF(1), PARD3(3), PPP2R1A(1), PPP2R1B(2), PPP2R3A(3), PPP2R3B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PTEN(1), RAB13(1), SPTAN1(2), SRC(1), SYMPK(5), TJP1(4), TJP2(4), TJP3(1), YES1(1) 16481601 173 25 167 55 48 32 29 26 38 0 0.322 1.000 1.000 526 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 125 CADM3(2), CD2(2), CD22(1), CD274(1), CD276(2), CD4(2), CD58(2), CD80(1), CD86(1), CDH1(1), CDH15(2), CDH2(3), CDH4(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CNTN1(3), CNTN2(1), CNTNAP1(1), CNTNAP2(4), ESAM(1), F11R(1), GLG1(1), HLA-A(3), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(2), ICAM1(1), ICAM3(1), ICOSLG(1), ITGA8(1), ITGAL(2), ITGAM(1), ITGAV(3), ITGB2(1), ITGB8(3), JAM2(1), L1CAM(1), MPZL1(1), NCAM1(2), NCAM2(5), NEGR1(1), NEO1(1), NFASC(1), NLGN1(4), NLGN2(2), NLGN3(4), NRCAM(1), NRXN1(2), NRXN2(2), NRXN3(2), PTPRC(2), PTPRF(6), PTPRM(5), PVRL2(1), SDC3(1), SDC4(2), SELP(3), SIGLEC1(6), VCAN(7) 12396103 123 22 119 44 35 17 26 18 27 0 0.316 1.000 1.000 527 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 146 AKT1(2), CBLB(1), CCND1(1), CCND2(1), CCND3(1), CREBBP(2), CSF2RB(1), CSF3R(1), EP300(4), EPOR(2), GHR(1), IFNA10(1), IFNA16(1), IFNAR1(2), IFNAR2(2), IFNGR1(2), IFNK(1), IL10RA(1), IL12B(1), IL20RA(2), IL21R(1), IL23R(1), IL26(1), IL28B(1), IL2RA(1), IL2RB(2), IL6(2), IL6ST(2), IL7(1), IL7R(1), IL9R(1), IRF9(2), JAK1(2), JAK2(2), JAK3(3), LIF(2), LIFR(4), OSMR(2), PIAS1(1), PIAS2(1), PIAS3(1), PIAS4(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRL(1), PRLR(2), PTPN6(4), SOCS4(1), SOS1(3), SOS2(1), SPRED2(1), SPRY4(2), STAM(3), STAM2(1), STAT1(1), STAT2(1), STAT3(1), STAT5A(1), STAT5B(1), STAT6(1), TPO(3), TSLP(1), TYK2(1) 12089873 108 22 106 41 27 22 16 19 24 0 0.654 1.000 1.000 528 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CACNA1C(6), CACNA1D(8), CACNA1F(1), CACNA1S(4), CALML6(1), CAMK2D(1), CDC42(1), CGA(1), EGFR(2), FSHB(1), GNA11(2), GNAQ(1), GNAS(6), GNRH1(1), GNRH2(1), GNRHR(1), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K2(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK7(4), MAPK8(1), MAPK9(1), MMP14(4), MMP2(2), PLA2G3(2), PLA2G6(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLD2(2), PRKACG(2), PRKCD(2), SOS1(3), SOS2(1), SRC(1) 10864023 128 21 122 35 35 23 23 18 26 3 0.0790 1.000 1.000 529 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2A(1), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHX58(1), ENPP3(2), ENTPD7(1), EP400(5), ERCC2(1), ERCC3(4), G6PC2(1), GAA(1), GANC(1), GBA3(2), GBE1(4), GCK(1), GPI(1), GYS1(1), HK1(2), HK2(2), HK3(2), IFIH1(3), LYZL1(1), MOV10L1(4), NUDT8(1), PGM1(1), PGM3(1), PYGB(2), PYGM(2), RAD54L(2), RUVBL2(2), SETX(3), SI(2), SKIV2L2(2), SMARCA2(2), UGDH(2), UGP2(2), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 10685266 98 20 93 41 18 22 14 18 25 1 0.929 1.000 1.000 530 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(4), ACACB(6), AKT1(2), ARAF(1), BAD(1), BRAF(1), CALML6(1), CBLB(1), CRK(1), EXOC7(1), FASN(9), FBP2(1), FLOT1(1), FLOT2(1), G6PC2(1), GCK(1), GSK3B(1), GYS1(1), HRAS(1), IKBKB(2), INPP5D(1), INSR(4), IRS2(1), IRS4(3), LIPE(1), MAPK10(1), MAPK8(1), MAPK9(1), PCK1(2), PCK2(3), PDE3A(7), PDE3B(1), PFKL(1), PFKM(1), PFKP(1), PHKA2(2), PHKB(2), PHKG1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PKLR(1), PPARGC1A(2), PPP1CA(1), PPP1R3A(1), PPP1R3D(1), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKACG(2), PRKAG3(1), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCI(3), PRKCZ(1), PTPRF(6), PYGB(2), PYGM(2), SHC1(1), SHC2(2), SHC4(2), SOCS4(1), SORBS1(1), SOS1(3), SOS2(1), TRIP10(1), TSC1(2), TSC2(4) 13666110 133 20 129 53 37 35 12 15 32 2 0.560 1.000 1.000 531 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), CALML6(1), CAMK2D(1), CREB1(1), CREB3L1(1), CREB3L2(3), CREB3L3(1), CREBBP(2), CTNNB1(6), DCT(4), DVL1(4), DVL2(2), EDN1(1), EDNRB(2), EP300(4), FZD1(4), FZD10(2), FZD2(1), FZD3(2), FZD6(1), FZD9(2), GNAI1(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAS(6), GSK3B(1), HRAS(1), KIT(3), LEF1(2), MITF(3), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PRKACG(2), TCF7(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT1(1), WNT10A(1), WNT11(1), WNT2(1), WNT2B(2), WNT3A(1), WNT5B(1), WNT7A(1), WNT7B(2), WNT8A(1) 9548115 117 18 114 37 42 22 16 18 19 0 0.0699 1.000 1.000 532 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALML6(1), CDIPT(1), DGKA(1), DGKB(2), DGKD(2), DGKG(1), DGKI(2), DGKQ(2), DGKZ(3), INPP4B(1), INPP5A(1), INPP5D(1), INPPL1(3), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), OCRL(1), PI4KA(3), PI4KB(2), PIK3C2A(4), PIK3C2B(10), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD3(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PTEN(1), SYNJ2(4) 10775430 102 17 100 31 32 15 12 19 24 0 0.192 1.000 1.000 533 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 BRAF(1), CHUK(1), CREB1(1), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAP3K10(3), MAP3K12(2), MAP3K13(1), MAP3K2(2), MAP3K7(2), MAP3K9(2), MAP4K1(2), MAP4K2(2), MAP4K3(1), MAP4K4(1), MAPK10(1), MAPK11(1), MAPK12(1), MAPK4(1), MAPK7(4), MAPK8(1), MAPK9(1), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(1), MAX(2), MEF2A(1), MEF2D(1), NFKBIA(2), PAK1(2), PAK2(2), RELA(1), RPS6KA1(1), RPS6KA2(1), RPS6KA4(2), RPS6KA5(1), SHC1(1), SP1(1), STAT1(1), TGFB1(1), TGFB2(2), TGFBR1(2), TRADD(1), TRAF2(1) 7924609 73 17 69 27 17 16 16 4 20 0 0.754 1.000 1.000 534 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 57 AKT1(2), BAD(1), CDC42(1), CREB1(1), ERBB4(6), F2RL2(1), GSK3A(1), GSK3B(1), IFI27(1), INPPL1(3), IRS2(1), IRS4(3), MET(4), PAK1(2), PAK2(2), PAK4(1), PAK6(1), PAK7(1), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PREX1(4), PTEN(1), PTK2(3), RPS6KA1(1), RPS6KA2(1), SHC1(1), SOS1(3), SOS2(1), TSC1(2), TSC2(4), YWHAE(2), YWHAH(1) 6115715 63 17 62 23 11 12 9 12 19 0 0.750 1.000 1.000 535 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 36 ACTA1(2), ACTA2(1), ACTN2(4), ACTN3(1), DES(1), DMD(5), FAM48A(1), MYBPC1(3), MYH3(1), MYH6(5), MYH7(4), MYH8(3), MYOM1(2), NEB(11), TNNC2(1), TNNI1(1), TNNI2(1), TNNI3(3), TNNT2(2), TNNT3(1), TPM2(1), TTN(58) 11629273 112 17 111 42 30 27 28 16 9 2 0.741 1.000 1.000 536 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(6), ATR(5), BRCA1(3), CDC25A(2), CDC25C(2), CDC34(1), CHEK2(1), EP300(4), MDM2(1), MYT1(9), PRKDC(6), RPS6KA1(1), YWHAH(1) 3461306 42 15 37 13 5 6 7 8 15 1 0.830 1.000 1.000 537 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(3), ADCY2(1), ADCY3(5), ADCY4(3), ADCY5(3), ADCY6(2), ADCY7(2), ADCY8(3), ADCY9(2), AKAP1(1), AKAP10(2), AKAP12(1), AKAP3(2), AKAP4(1), AKAP6(2), AKAP7(3), ARHGEF1(3), GNA11(2), GNA15(1), GNAI2(1), GNAO1(2), GNAQ(1), GNAZ(2), GNB1(1), GNB3(1), GNB5(1), HRAS(1), ITPR1(5), PDE1B(1), PDE4A(1), PDE4C(1), PDE4D(1), PDE7B(1), PDE8A(1), PDE8B(1), PLCB3(2), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), PRKCD(2), PRKCE(1), PRKCH(3), PRKCI(3), PRKCQ(2), PRKCZ(1), PRKD3(3) 9445943 89 15 88 33 31 15 17 11 13 2 0.419 1.000 1.000 538 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 64 ADCY1(3), ADCY8(3), ARAF(1), BRAF(1), CACNA1C(6), CALML6(1), CAMK2D(1), CAMK4(2), CREBBP(2), EP300(4), GNAQ(1), GRIA1(1), GRIN2A(4), GRIN2B(3), GRIN2C(5), GRIN2D(4), GRM5(4), HRAS(1), ITPR1(5), ITPR2(3), ITPR3(6), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PPP1CA(1), PPP3CA(1), PPP3CC(1), PRKACG(2), RAP1B(1), RAPGEF3(2), RPS6KA1(1), RPS6KA2(1) 8328162 79 15 79 31 24 12 13 12 16 2 0.659 1.000 1.000 539 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 INPP4B(1), INPP5A(1), INPPL1(3), ISYNA1(1), ITPKB(3), OCRL(1), PI4KA(3), PI4KB(2), PIK3C3(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIP4K2B(1), PIP4K2C(1), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB3(2), PLCB4(2), PLCD3(2), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(4), PTEN(1), SYNJ2(4) 6360722 53 13 51 20 10 9 7 13 14 0 0.668 1.000 1.000 540 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(4), ALPL(1), ALPP(4), ALPPL2(2), ASCC3(3), ATP13A2(1), DDX18(1), DDX4(5), DDX41(1), DDX47(2), DDX50(2), DDX51(1), DDX54(2), DDX56(2), DHFR(1), DHX58(1), ENTPD7(1), EP400(5), ERCC2(1), ERCC3(4), FPGS(3), GCH1(1), GGH(1), IFIH1(3), MOV10L1(4), NUDT8(1), QDPR(1), RAD54L(2), RUVBL2(2), SETX(3), SKIV2L2(2), SMARCA2(2) 5455059 69 13 66 29 14 14 7 15 18 1 0.891 1.000 1.000 541 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(2), BTK(1), FCER1A(1), GAB2(2), HRAS(1), INPP5D(1), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAPK10(1), MAPK11(1), MAPK12(1), MAPK8(1), MAPK9(1), MS4A2(3), PDK1(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PRKCD(2), PRKCE(1), RAC2(1), SOS1(3), SOS2(1), SYK(2), VAV1(4), VAV3(1) 6114769 61 13 60 22 15 17 8 7 13 1 0.460 1.000 1.000 542 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(4), ACTN3(1), ARHGAP5(3), BCAR1(2), CDC42(1), CDH5(2), CLDN17(2), CLDN3(1), CLDN9(1), CTNNA1(3), CTNNA2(3), CTNNA3(2), CTNNB1(6), CTNND1(1), CXCR4(3), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), ICAM1(1), ITGAL(2), ITGAM(1), ITGB2(1), ITK(1), JAM2(1), MAPK11(1), MAPK12(1), MLLT4(4), MMP2(2), MMP9(2), MYLPF(1), NCF2(1), NOX1(2), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLCG1(1), PLCG2(4), PTK2(3), RAC2(1), RAP1B(1), RAPGEF3(2), RAPGEF4(3), RHOH(1), ROCK1(2), ROCK2(1), SIPA1(3), VAV1(4), VAV3(1), VCL(1) 10747256 101 13 100 37 30 20 13 16 20 2 0.438 1.000 1.000 543 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(2), BRD4(4), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(1), GSK3B(1), INPPL1(3), IRS2(1), IRS4(3), LNPEP(2), PARD3(3), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PTEN(1), RPS6KA1(1), RPS6KA2(1), SHC1(1), SORBS1(1), SOS1(3), SOS2(1), YWHAE(2), YWHAH(1) 4765984 40 13 40 17 7 11 2 8 12 0 0.814 1.000 1.000 544 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG10(1), ALG10B(1), ALG12(2), ALG9(2), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(1), B4GALT5(2), CHPF(1), CHST11(1), CHST12(1), CHST14(1), CHST2(1), CHST4(1), CHST6(3), CHSY1(1), DDOST(1), DPAGT1(2), EXT1(2), EXT2(2), EXTL2(2), EXTL3(5), GALNT1(1), GALNT10(1), GALNT13(1), GALNT14(1), GALNT4(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT8(1), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(1), GANAB(2), HS2ST1(1), HS3ST2(3), HS6ST1(2), HS6ST2(1), MAN1A2(1), MAN1B1(1), MAN2A1(4), MGAT1(1), MGAT2(1), MGAT3(1), MGAT5(1), MGAT5B(1), NDST1(2), NDST3(3), NDST4(2), OGT(1), ST3GAL1(2), ST6GAL1(1), XYLT1(2), XYLT2(4) 9568816 87 12 84 29 27 16 17 11 16 0 0.310 1.000 1.000 545 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(2), ASAH1(1), ATF1(1), BRAF(1), CAMP(2), CREB1(1), CREBBP(2), DAG1(2), EGR3(1), GNAQ(1), MAP1B(5), MAP2K4(2), MAP2K7(2), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), NTRK1(2), OPN1LW(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SHC1(1), SRC(1), TERF2IP(1) 4442584 40 12 40 19 11 7 6 5 11 0 0.870 1.000 1.000 546 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(1), CPEB1(1), EGFR(2), ERBB2(5), ERBB4(6), ETS1(1), ETS2(2), ETV7(1), FMN2(4), NOTCH1(7), NOTCH3(7), NOTCH4(4), PIWIL1(1), PIWIL2(3), PIWIL3(1), PIWIL4(1), SOS1(3), SOS2(1) 4127727 51 11 49 22 15 8 11 7 10 0 0.875 1.000 1.000 547 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(6), ACSL1(1), ACSL3(3), ACSL5(1), ADIPOR1(2), AKT1(2), CAMKK1(1), CHUK(1), CPT1B(3), CPT1C(2), CPT2(1), G6PC2(1), IKBKB(2), IRS2(1), IRS4(3), JAK1(2), JAK2(2), JAK3(3), MAPK10(1), MAPK8(1), MAPK9(1), NFKBIA(2), NFKBIE(1), NPY(2), PCK1(2), PCK2(3), PPARA(1), PPARGC1A(2), PRKAA2(1), PRKAB1(1), PRKAB2(1), PRKAG3(1), PRKCQ(2), RELA(1), SLC2A1(2), STAT3(1), STK11(1), TNFRSF1A(2), TNFRSF1B(2), TRADD(1), TRAF2(1), TYK2(1) 7043244 71 11 70 26 17 16 11 10 16 1 0.438 1.000 1.000 548 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), EGF(2), EGFR(2), ETS1(1), ETS2(2), HOXA7(1), HRAS(1), IKBKB(2), MAP2K4(2), MAP2K6(3), MAP2K7(2), MAP3K1(3), MAPK8(1), NFKBIA(2), PRKCD(2), PRKCE(1), PRKCH(3), PRKCQ(2), RELA(1), SP1(1), TNFRSF1A(2), TNFRSF1B(2), TRAF2(1) 4137436 40 11 39 15 9 8 10 5 8 0 0.601 1.000 1.000 549 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(4), CTPS2(1), DPYD(4), DPYS(4), DUT(1), NT5E(1), NT5M(1), POLD1(1), POLD2(1), POLE(7), POLG(5), POLL(3), POLQ(2), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(2), RRM1(1), TYMS(1), UMPS(2), UPB1(2) 4995602 51 11 51 18 14 12 9 6 10 0 0.463 1.000 1.000 550 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATM(6), ATR(5), BRCA1(3), BRCA2(6), CHEK2(1), FANCA(3), FANCC(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD17(2), TREX1(1) 3606338 34 10 33 11 4 8 6 8 8 0 0.698 1.000 1.000 551 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(2), BAD(1), CDC42(1), HRAS(1), KDR(1), MAPK11(1), MAPK12(1), MAPKAPK2(1), MAPKAPK3(1), NFATC1(4), NFATC2(4), NFATC3(2), NFATC4(4), NOS3(6), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PLA2G3(2), PLA2G6(3), PLCG1(1), PLCG2(4), PPP3CA(1), PPP3CC(1), PTK2(3), RAC2(1), SH2D2A(1), SHC2(2), SPHK1(1), SRC(1) 6004500 63 10 63 25 16 18 10 7 12 0 0.567 1.000 1.000 552 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), BAIAP2(1), CASP1(2), CASP7(1), CASP8(2), INSR(4), ITCH(2), MAGI1(1), MAGI2(6), RERE(5), WWP1(1), WWP2(1) 2076557 29 10 29 11 7 7 2 4 9 0 0.717 1.000 1.000 553 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2F1(2), NCOA2(2), NCOA3(3), NCOR2(5), POLR2A(2), TBP(1) 2179117 19 10 17 19 3 3 3 1 8 1 1.000 1.000 1.000 554 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(3), AKT1(2), DAG1(2), GNAQ(1), ITPKB(3), ITPR1(5), ITPR2(3), ITPR3(6), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1) 3917384 35 10 35 12 9 5 6 5 10 0 0.617 1.000 1.000 555 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), BRAF(1), CAB39(1), DDIT4(1), EIF4B(2), HIF1A(1), PIK3CA(1), PIK3CB(1), PIK3CD(1), PIK3CG(3), PIK3R1(1), PIK3R2(2), PIK3R3(1), PIK3R5(2), PRKAA2(1), RICTOR(5), RPS6KA1(1), RPS6KA2(1), STK11(1), TSC1(2), TSC2(4), ULK1(2), ULK3(1), VEGFB(2) 4648381 40 9 39 19 11 12 4 3 10 0 0.897 1.000 1.000 556 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 70 CD4(2), CREB1(1), CTSB(2), CTSS(1), HLA-A(3), HLA-DPA1(1), HLA-DQA2(1), HLA-DRB5(2), HSP90AA1(4), HSP90AB1(1), HSPA5(3), IFI30(1), IFNA10(1), IFNA16(1), KIR2DL1(1), KIR3DL2(3), KLRC1(1), KLRC2(2), NFYC(1), PDIA3(2), RFX5(1), TAP1(1) 3787033 36 9 35 14 3 7 6 9 11 0 0.823 1.000 1.000 557 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 30 AKT1(2), BAD(1), CFLAR(2), HRAS(1), IL2RA(1), IL2RB(2), JAK1(2), JAK3(3), PIK3CA(1), PIK3R1(1), PTPN6(4), SHC1(1), SOS1(3), STAT5A(1), STAT5B(1), SYK(2) 2662257 28 9 27 10 6 6 4 5 7 0 0.694 1.000 1.000 558 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 CITED2(1), CPT1B(3), CREBBP(2), DUT(1), EP300(4), HSD17B4(2), LPL(2), ME1(2), NCOR1(6), NCOR2(5), NFKBIA(2), NR1H3(2), NRIP1(1), PIK3CA(1), PIK3R1(1), PPARA(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RB1(1), RELA(1), SP1(1), STAT5A(1), STAT5B(1) 5408760 47 9 47 19 10 12 9 6 10 0 0.665 1.000 1.000 559 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), BAD(1), BCR(1), BLNK(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(1), ITPKB(3), NFKBIA(2), NFKBIE(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), PLCG2(4), SHC1(1), SOS1(3), SOS2(1), SYK(2), VAV1(4) 4319888 35 9 35 12 11 7 3 7 6 1 0.478 1.000 1.000 560 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 55 BAK1(1), BFAR(2), BTK(1), CAD(4), CASP10(1), CASP8(2), CASP8AP2(2), DEDD(1), EGFR(2), EPHB2(1), MAP2K4(2), MAP2K7(2), MAP3K1(3), MAPK10(1), MAPK8(1), MAPK8IP1(1), MAPK8IP2(1), MAPK8IP3(3), MAPK9(1), MET(4), NFKBIA(2), NFKBIE(1), PTPN13(3), RALBP1(2), ROCK1(2), TPX2(2), TRAF2(1) 5806092 49 9 49 18 10 10 12 8 9 0 0.635 1.000 1.000 561 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), AOX1(1), CARM1(1), DCT(4), ESCO1(4), ESCO2(1), GOT1(2), HEMK1(1), HGD(2), HPD(3), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TPO(3), TYR(2) 5134431 50 8 50 18 16 9 11 6 8 0 0.444 1.000 1.000 562 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(6), ATR(5), BAI1(1), CASP8(2), CCNB2(1), CCND1(1), CCND2(1), CCND3(1), CCNE1(1), CCNE2(1), CCNG2(2), CDK4(2), CHEK2(1), EI24(1), FAS(1), GTSE1(2), MDM2(1), PERP(1), PTEN(1), RRM2B(1), SERPINB5(1), SERPINE1(1), SESN2(2), SESN3(2), STEAP3(1), THBS1(1), TNFRSF10B(2), TSC2(4), ZMAT3(2) 5487781 52 8 52 21 11 13 12 7 9 0 0.701 1.000 1.000 563 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 40 ADAM17(3), APH1A(2), CREBBP(2), CTBP2(2), DLL4(1), DTX1(3), DVL1(4), DVL2(2), EP300(4), JAG2(3), LFNG(1), MAML1(2), MAML2(1), NCOR2(5), NOTCH1(7), NOTCH3(7), NOTCH4(4), NUMBL(1), PSEN1(1), PSEN2(1), RBPJ(2), SNW1(1) 5499467 59 8 58 29 19 17 8 6 9 0 0.766 1.000 1.000 564 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(5), ARRB2(2), CALML6(1), CAMK2D(1), CLCA1(1), CLCA2(1), CLCA4(3), CNGA3(1), CNGA4(1), CNGB1(6), GUCA1A(1), GUCA1C(1), PRKACG(2), PRKG1(1), PRKG2(1) 2640029 28 8 26 13 8 3 9 3 5 0 0.916 1.000 1.000 565 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(2), CBR3(2), CYP4F2(3), CYP4F3(1), EPX(4), LPO(4), LTA4H(1), MPO(2), PLA2G3(2), PLA2G6(3), PRDX1(1), PTGDS(2), PTGIS(2), TBXAS1(1), TPO(3) 2425130 33 8 32 14 12 3 8 2 8 0 0.774 1.000 1.000 566 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(3), DDX20(1), E2F4(3), ETS1(1), ETS2(2), HDAC5(2), HRAS(1), NCOR2(5), RBL1(1), RBL2(2), SIN3A(3) 2295405 25 7 24 11 4 6 5 3 7 0 0.835 1.000 1.000 567 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), CPT1B(3), DAO(3), DMGDH(3), GARS(5), GLDC(2), PISD(1), PLCB2(3), PLCG1(1), PLCG2(4), SARDH(1), SHMT1(1), SHMT2(3), TARS(2) 3672844 41 7 41 18 13 12 6 5 5 0 0.623 1.000 1.000 568 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(2), AGXT2(1), ALAS2(2), AOC2(1), AOC3(2), CHDH(1), DAO(3), DMGDH(3), GARS(5), GLDC(2), HSD3B7(2), PHGDH(1), PISD(1), RDH11(2), SARDH(1), SARS2(1), SHMT1(1), SHMT2(3), TARS(2) 3734738 36 7 36 16 13 10 5 5 3 0 0.637 1.000 1.000 569 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(2), HRAS(1), IL6(2), IL6ST(2), JAK1(2), JAK2(2), JAK3(3), SHC1(1), SOS1(3), STAT3(1) 2086017 19 7 18 13 2 3 4 3 7 0 0.994 1.000 1.000 570 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 91 ANK2(7), B3GALT4(1), DGKI(2), IL6ST(2), RPL10(2), RPL18A(1), RPL24(1), RPL35(1), RPL3L(2), RPL4(2), RPL7A(1), RPS11(2), RPS27A(1), RPS28(1), RPS6KA1(1), RPS6KA2(1), SLC36A2(1), TSPAN9(1), UBC(1) 4472465 31 7 30 20 9 4 7 5 6 0 0.992 1.000 1.000 571 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 35 CDK7(1), ERCC3(4), GTF2E2(1), GTF2H1(1), GTF2H4(1), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLR3E(3), TAF5(1), TBP(1) 2805564 23 7 21 10 9 4 3 1 6 0 0.793 1.000 1.000 572 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), BAD(1), GSK3A(1), GSK3B(1), IRS2(1), JAK1(2), JAK3(3), MAP4K1(2), PDK1(1), PIK3CA(1), PIK3CD(1), PIK3R1(1), SHC1(1), SOS1(3), SOS2(1), STAT6(1) 2861840 23 7 22 12 5 7 1 3 7 0 0.918 1.000 1.000 573 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), ARHGEF11(3), CDC42(1), DLG4(1), LPA(3), MAP2K4(2), MAP3K1(3), MAPK8(1), NFKBIA(2), NFKBIE(1), PDK1(1), PHKA2(2), PIK3CB(1), PLD2(2), PLD3(1), PTK2(3), RDX(2), ROCK1(2), ROCK2(1), TBXA2R(1) 4249967 35 7 35 11 5 5 9 9 7 0 0.636 1.000 1.000 574 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(1), AZIN1(1), CRY1(1), GFRA1(2), GSTP1(1), HSPA8(2), MYF6(1), NCKAP1(4), NCOA4(1), PER1(2), PER2(3), TOB1(2), TUBB3(1), UCP3(1), UGP2(2) 2846905 25 6 24 12 6 5 3 7 4 0 0.809 1.000 1.000 575 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CARM1(1), CAT(1), CYP1A1(1), CYP1A2(2), CYP1B1(1), GCDH(2), HADHA(1), HEMK1(1), HSD17B4(2), INMT(1), KMO(2), KYNU(1), LCMT1(1), LCMT2(1), LNX1(1), METTL6(1), OGDH(5), OGDHL(1), PRMT3(1), PRMT6(1), PRMT8(1), TDO2(1), TPH1(2), TPH2(2), WARS(2) 5225886 48 6 46 10 14 6 13 5 10 0 0.107 1.000 1.000 576 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(2), CBR3(2), CYP2B6(1), CYP2C19(3), CYP2E1(1), CYP2J2(2), CYP4A22(1), CYP4F2(3), CYP4F3(1), DHRS4(1), GPX5(3), LTA4H(1), PLA2G3(2), PLA2G6(3), PTGDS(2), PTGIS(2), TBXAS1(1) 3388601 31 6 30 20 7 5 10 1 8 0 0.987 1.000 1.000 577 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(2), CRK(1), DOCK1(2), HRAS(1), ITGA1(4), MAP4K1(2), MAPK8(1), MET(4), PAK1(2), PIK3CA(1), PIK3R1(1), PTEN(1), PTK2(3), RAP1B(1), RASA1(1), SOS1(3), SRC(1), STAT3(1) 3865320 32 6 31 13 5 12 3 5 7 0 0.694 1.000 1.000 578 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(1), CRHR2(1), ELTD1(4), EMR2(3), GHRHR(1), GLP2R(3), GPR64(1), LPHN1(1), LPHN2(4), VIPR1(1), VIPR2(1) 2334482 21 5 21 11 6 2 4 6 3 0 0.838 1.000 1.000 579 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(2), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), G6PC2(1), GAPDHS(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKL(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 5014183 47 5 47 14 19 11 7 4 6 0 0.131 1.000 1.000 580 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSE(1), CARM1(1), CYP11B1(2), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD3B1(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(1), PRMT6(1), PRMT8(1), STS(2), SULT2A1(1), UGT1A1(2), UGT2A3(1), UGT2B10(2), UGT2B15(1), UGT2B4(1) 4314388 27 5 27 11 3 10 8 2 4 0 0.706 1.000 1.000 581 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIT1(3), CTBS(1), CYB5R3(2), GFPT1(1), GFPT2(1), GNE(2), GNPDA1(2), HEXB(1), HK1(2), HK2(2), HK3(2), MTMR6(1), NAGK(1), PGM3(1), PHPT1(1), RENBP(1) 2483054 24 5 24 12 7 3 6 3 5 0 0.850 1.000 1.000 582 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), GALNS(1), GLB1(1), HEXB(1), HGSNAT(1), HPSE2(1), HYAL1(2), LCT(3), MAN2B2(1), MANBA(2), NAGLU(2), NEU4(1) 3041857 21 5 21 12 7 5 4 0 5 0 0.811 1.000 1.000 583 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(3), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CUL1(1), CUL3(1), FBXW11(2), FBXW7(3), ITCH(2), SKP1(1), TCEB1(1), UBE2D1(1), UBE2E1(1), UBE2E3(1), WWP1(1), WWP2(1) 3335651 28 5 28 11 7 8 6 3 4 0 0.723 1.000 1.000 584 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 40 ACTG2(2), ADCY3(5), ADCY9(2), ARF1(1), ARF4(1), ARL4D(2), ATP6V0A1(2), ATP6V0A2(1), ATP6V0A4(2), ATP6V1F(1), GNAS(6), PDIA4(1), PLCG1(1), PLCG2(4), SEC61A1(1), SEC61A2(2), SEC61G(1) 3125811 35 5 34 9 12 8 8 5 2 0 0.160 1.000 1.000 585 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(3), AASS(1), ACAT1(2), ALDH1A3(1), ALDH3A1(1), DOT1L(1), EHMT1(3), EHMT2(2), GCDH(2), HADHA(1), PLOD1(1), PLOD2(1), SHMT1(1), SHMT2(3) 3209730 23 5 23 12 6 5 7 0 5 0 0.876 1.000 1.000 586 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA2A(1), ADRA2C(2), CHRM2(3), CHRM3(2), CHRM5(3), DRD1(2), DRD2(1), HTR1A(2), HTR1D(1), HTR1E(1), HTR1F(1), HTR2A(1), HTR2B(1), HTR4(2), HTR5A(3), HTR6(1), HTR7(1) 2256157 29 5 29 12 9 5 8 5 2 0 0.605 1.000 1.000 587 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CHUK(1), EGR3(1), GNAQ(1), MAP3K1(3), NFATC1(4), NFATC2(4), NFKBIA(2), PLCG1(1), PPP3CA(1), PPP3CC(1), PRKACG(2), PRKAR1A(1), PRKAR1B(2), PRKAR2B(1), RELA(1), VIPR2(1) 2341274 27 5 27 11 7 6 5 3 6 0 0.678 1.000 1.000 588 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4) 595386 10 4 8 11 3 3 1 0 3 0 0.985 1.000 1.000 589 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(2), EGFR(2), MAP3K1(3), NCOR2(5) 1514202 12 4 12 10 1 3 2 2 4 0 0.989 1.000 1.000 590 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), PGD(1) 1589099 19 4 18 11 3 5 2 4 5 0 0.897 1.000 1.000 591 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(4) 595386 10 4 8 11 3 3 1 0 3 0 0.985 1.000 1.000 592 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(2), GPX5(3), GSTA1(2), GSTA2(1), GSTA3(1), GSTA4(1), GSTA5(2), GSTM4(1), GSTO2(1), GSTP1(1), IDH1(1), IDH2(3), MGST2(1), OPLAH(3) 1958548 23 4 22 13 5 6 4 3 5 0 0.865 1.000 1.000 593 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 4203400 40 3 40 13 16 9 6 4 5 0 0.221 1.000 1.000 594 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), ALDOB(1), BPGM(1), DLAT(3), ENO1(1), FBP2(1), GCK(1), GPI(1), HK1(2), HK2(2), HK3(2), LDHB(1), PDHA1(1), PFKM(1), PFKP(1), PGAM1(1), PGK1(2), PGM1(1), PGM3(1), PKLR(1), TPI1(2) 4203400 40 3 40 13 16 9 6 4 5 0 0.221 1.000 1.000 595 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(2), POLR2B(1), POLR2E(1), POLR2J(1), POLRMT(2) 1179836 9 3 9 8 5 2 1 1 0 0 0.964 1.000 1.000 596 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ABP1(2), ACAT1(2), ALDH1A3(1), ALDH3A1(1), AOC2(1), AOC3(2), AOX1(1), ASMT(2), CAT(1), CYP19A1(1), CYP1A1(1), CYP1A2(2), CYP2A13(2), CYP2A7(1), CYP2B6(1), CYP2C19(3), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP2J2(2), CYP3A7(3), GCDH(2), HADHA(1), KMO(2), KYNU(1), TDO2(1), TPH1(2), WARS(2) 4649836 44 3 44 12 14 6 12 6 6 0 0.189 1.000 1.000 597 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 4 CYP1A2(2), CYP2E1(1) 383920 3 2 3 4 3 0 0 0 0 0 0.979 1.000 1.000 598 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(2), ALDH1A3(1), ALDH3A1(1), ALDH3B1(2), ALDH3B2(1), AOC2(1), AOC3(2), HAL(1), PRPS1(1) 2105690 12 2 12 6 6 4 1 1 0 0 0.594 1.000 1.000 599 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH3A1(1) 690280 2 1 2 2 2 0 0 0 0 0 0.904 1.000 1.000 600 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A3(1), ALDH3A1(1) 690280 2 1 2 2 2 0 0 0 0 0 0.904 1.000 1.000 601 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NQO2(2), SQLE(1), VKORC1(2) 968127 11 1 11 6 2 3 5 1 0 0 0.802 1.000 1.000 602 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 14 DHCR7(1), FDFT1(2), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1) 1058688 8 1 8 6 2 2 4 0 0 0 0.924 1.000 1.000 603 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADL(1), ACADS(1), ACADSB(2), ACAT1(2), ACOX3(1), ACSL1(1), ACSL3(3), ACSL5(1), ADH1A(1), ADH1B(1), ADH4(1), ADH5(1), ADH6(1), ADH7(2), ADHFE1(2), ALDH1A3(1), ALDH3A1(1), CPT1B(3), CPT1C(2), CPT2(1), CYP4A22(1), GCDH(2), HADHA(1), HADHB(2), HSD17B4(2) 4209314 38 1 38 8 12 11 5 4 6 0 0.0446 1.000 1.000 604 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 23 DHCR7(1), FDFT1(2), GGCX(1), HMGCR(1), LSS(1), MVK(1), NSDHL(1), SQLE(1), VKORC1(2) 1589816 11 1 11 7 3 2 5 1 0 0 0.886 1.000 1.000 605 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(1), KARS(1) 403590 2 1 2 3 0 0 1 1 0 0 0.989 1.000 1.000 606 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(1) 393021 2 1 2 2 1 1 0 0 0 0 0.914 1.000 1.000 607 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(1), PNPO(1) 417727 2 1 2 2 0 0 2 0 0 0 0.946 1.000 1.000 608 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), SQLE(1) 367777 3 1 3 3 1 1 1 0 0 0 0.922 1.000 1.000 609 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(1) 579743 2 1 2 2 1 1 0 0 0 0 0.886 1.000 1.000 610 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(1), CUL1(1), RB1(1) 739343 3 1 3 4 0 1 1 1 0 0 0.989 1.000 1.000 611 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(2), CCNE1(1), CDC34(1), CUL1(1), RB1(1) 740661 6 1 6 4 1 2 2 1 0 0 0.911 1.000 1.000 612 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), SQLE(1) 275947 3 1 3 3 1 1 1 0 0 0 0.921 1.000 1.000 613 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 6 THBS1(1) 528867 1 1 1 2 1 0 0 0 0 0 0.950 1.000 1.000 614 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 198111 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 43203 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 2 67629 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000