HotNet pathway analysis of mutation and copy number data
Prostate Adenocarcinoma (Primary solid tumor)
23 September 2013
|
analyses__2013_09_23
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2013):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C1NG4P0K
Overview
Introduction
Summary
There were 3 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 3 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 3 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| LAMB1(14),PDE4DIP(10),RINT1(15),GFI1B(10) | 4 | 0.0135 | 1 |
| NRCAM(15),MET(14),PTPRB(6),TNC(11) | 4 | 0.0135 | 1 |
| NEFM(53),TNFRSF10C(54),TNFRSF10A(54),PON1(15),SCARB1(7) | 5 | 0.0160 | 1 |
Methods & Data
Copyright © 2013
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.