Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.005 0.079 0.354 4.0 -9999.0 0.0 4.0 EGFR 0.007 0.087 -9999.0 0.0 -0.409 8.0 8.0 EPHA2 -0.016 0.13 -9999.0 0.0 -0.384 21.0 21.0 MYO6 -0.011 0.07 0.214 12.0 -9999.0 0.0 12.0 CTNNB1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.19 0.216 -9999.0 0.0 -0.415 92.0 92.0 CTNND1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.005 0.058 0.209 13.0 -9999.0 0.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.062 0.196 12.0 -9999.0 0.0 12.0 EGF -0.016 0.11 -9999.0 0.0 -0.269 29.0 29.0 NCKAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.01 0.074 0.362 1.0 -0.437 4.0 5.0 cortical microtubule organization 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.005 0.055 0.198 13.0 -9999.0 0.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.057 0.026 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.028 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.038 0.079 -9999.0 0.0 -0.225 13.0 13.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.008 0.028 0.177 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.0 0.045 0.204 8.0 -9999.0 0.0 8.0 ARF6/GTP 0.044 0.079 -9999.0 0.0 -0.211 13.0 13.0 CDH1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.016 0.074 -9999.0 0.0 -0.324 2.0 2.0 RhoA/GDP 0.053 0.024 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.014 0.061 0.188 9.0 -0.271 1.0 10.0 IGF-1R heterotetramer 0.023 0.041 -9999.0 0.0 -0.291 3.0 3.0 GIT1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.023 0.041 -9999.0 0.0 -0.291 3.0 3.0 IGF1 -0.011 0.119 -9999.0 0.0 -0.363 19.0 19.0 DIAPH1 0.035 0.109 -9999.0 0.0 -0.596 2.0 2.0 Wnt receptor signaling pathway -0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.061 0.19 9.0 -0.277 1.0 10.0 EFNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.002 0.054 0.225 8.0 -9999.0 0.0 8.0 Ephrin A1/EPHA2 0.024 0.071 -9999.0 0.0 -0.2 10.0 10.0 SEC6/SEC8 -0.014 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.003 0.063 0.198 12.0 -9999.0 0.0 12.0 HGF/MET 0.021 0.073 -9999.0 0.0 -0.245 8.0 8.0 HGF 0.004 0.079 -9999.0 0.0 -0.27 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.035 0.106 0.291 18.0 -0.258 2.0 20.0 KIAA1543 0.003 0.05 0.187 12.0 -9999.0 0.0 12.0 KIFC3 -0.007 0.039 0.179 6.0 -0.204 2.0 8.0 NCK1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.003 0.054 0.219 10.0 -9999.0 0.0 10.0 NCK1/GIT1 0.038 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.005 0.057 0.214 12.0 -9999.0 0.0 12.0 PIP5K1C 0.005 0.059 0.211 13.0 -9999.0 0.0 13.0 LIMA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.096 0.375 6.0 -9999.0 0.0 6.0 adherens junction assembly -0.003 0.095 0.327 3.0 -0.442 4.0 7.0 IGF-1R heterotetramer/IGF1 0.025 0.068 -9999.0 0.0 -0.2 10.0 10.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.007 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.003 0.097 -9999.0 0.0 -0.409 10.0 10.0 PLEKHA7 0.004 0.052 0.198 12.0 -9999.0 0.0 12.0 mol:GTP 0.037 0.078 -9999.0 0.0 -0.223 13.0 13.0 establishment of epithelial cell apical/basal polarity 0.017 0.093 0.373 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.014 0.061 0.188 9.0 -0.271 1.0 10.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.022 0.014 -9999.0 0.0 -9999.0 0.0 0.0