Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Syndecan-1-mediated signaling events	36.0	1233.0	34.0	-0.84	0.013	1000.0	-1000.0	-0.06	-1000.0
Reelin signaling pathway	24.0	1362.0	56.0	-0.726	0.04	1000.0	-1000.0	-0.09	-1000.0
IL23-mediated signaling events	17.0	1039.0	60.0	-0.685	0.021	1000.0	-1000.0	-0.186	-1000.0
TCGA08_retinoblastoma	16.0	130.0	8.0	-0.201	0.065	1000.0	-1000.0	-0.024	-1000.0
Osteopontin-mediated events	15.0	570.0	38.0	-0.341	0.02	1000.0	-1000.0	-0.11	-1000.0
Glypican 1 network	15.0	762.0	48.0	-0.605	0.03	1000.0	-1000.0	-0.052	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	14.0	780.0	54.0	-0.705	0.026	1000.0	-1000.0	-0.109	-1000.0
TCGA08_p53	14.0	104.0	7.0	-0.153	0.074	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by the Hedgehog family	12.0	651.0	52.0	-0.311	0.265	1000.0	-1000.0	-0.056	-1000.0
IL4-mediated signaling events	12.0	1116.0	91.0	-0.791	0.64	1000.0	-1000.0	-0.191	-1000.0
Wnt signaling	11.0	77.0	7.0	-0.247	0.013	1000.0	-1000.0	-0.029	-1000.0
Caspase cascade in apoptosis	10.0	765.0	74.0	-0.277	0.129	1000.0	-1000.0	-0.052	-1000.0
FOXA2 and FOXA3 transcription factor networks	10.0	505.0	46.0	-0.745	0.02	1000.0	-1000.0	-0.154	-1000.0
Syndecan-4-mediated signaling events	8.0	555.0	67.0	-0.538	0.053	1000.0	-1000.0	-0.078	-1000.0
HIF-1-alpha transcription factor network	7.0	540.0	76.0	-0.812	0.022	1000.0	-1000.0	-0.172	-1000.0
BMP receptor signaling	7.0	596.0	81.0	-0.372	0.049	1000.0	-1000.0	-0.108	-1000.0
Glucocorticoid receptor regulatory network	7.0	905.0	114.0	-0.762	0.348	1000.0	-1000.0	-0.077	-1000.0
Endothelins	7.0	694.0	96.0	-0.487	0.051	1000.0	-1000.0	-0.088	-1000.0
Canonical Wnt signaling pathway	7.0	377.0	51.0	-0.56	0.253	1000.0	-1000.0	-0.072	-1000.0
Syndecan-2-mediated signaling events	6.0	434.0	69.0	-0.517	0.036	1000.0	-1000.0	-0.036	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	403.0	61.0	-0.559	0.222	1000.0	-1000.0	-0.08	-1000.0
HIF-2-alpha transcription factor network	6.0	290.0	43.0	-0.314	0.217	1000.0	-1000.0	-0.081	-1000.0
Glypican 2 network	6.0	27.0	4.0	-0.07	-0.053	1000.0	-1000.0	-0.02	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	199.0	31.0	-0.58	0.013	1000.0	-1000.0	-0.07	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	173.0	34.0	-0.07	0.013	1000.0	-1000.0	-0.06	-1000.0
IL1-mediated signaling events	5.0	332.0	62.0	-0.309	0.06	1000.0	-1000.0	-0.107	-1000.0
Ephrin B reverse signaling	5.0	253.0	48.0	-0.102	0.04	1000.0	-1000.0	-0.071	-1000.0
Visual signal transduction: Rods	5.0	263.0	52.0	-0.183	0.013	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by PRL	5.0	195.0	34.0	-0.257	0.059	1000.0	-1000.0	-0.033	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	95.0	17.0	-0.071	0.02	1000.0	-1000.0	-0.053	-1000.0
Ephrin A  reverse signaling	4.0	33.0	7.0	-0.06	-0.0	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	76.0	17.0	-0.114	0.027	1000.0	-1000.0	-0.041	-1000.0
Noncanonical Wnt signaling pathway	4.0	106.0	26.0	-0.247	0.013	1000.0	-1000.0	-0.059	-1000.0
Aurora A signaling	4.0	252.0	60.0	-0.445	0.037	1000.0	-1000.0	-0.041	-1000.0
amb2 Integrin signaling	4.0	385.0	82.0	-0.163	0.018	1000.0	-1000.0	-0.078	-1000.0
S1P1 pathway	4.0	178.0	36.0	-0.141	0.015	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	4.0	245.0	58.0	-0.296	0.028	1000.0	-1000.0	-0.088	-1000.0
Syndecan-3-mediated signaling events	4.0	157.0	35.0	-0.517	0.04	1000.0	-1000.0	-0.053	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	4.0	304.0	68.0	-0.58	0.048	1000.0	-1000.0	-0.135	-1000.0
BCR signaling pathway	4.0	429.0	99.0	-0.136	0.017	1000.0	-1000.0	-0.102	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	381.0	78.0	-0.075	0.029	1000.0	-1000.0	-0.07	-1000.0
IL12-mediated signaling events	3.0	264.0	87.0	-0.216	0.047	1000.0	-1000.0	-0.153	-1000.0
ErbB4 signaling events	3.0	228.0	69.0	-0.445	0.077	1000.0	-1000.0	-0.096	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	86.0	28.0	-0.141	0.02	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Cones	3.0	145.0	38.0	-0.154	0.019	1000.0	-1000.0	-0.041	-1000.0
p75(NTR)-mediated signaling	3.0	465.0	125.0	-1.002	0.04	1000.0	-1000.0	-0.106	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	302.0	97.0	-0.105	0.033	1000.0	-1000.0	-0.105	-1000.0
IFN-gamma pathway	3.0	240.0	68.0	-0.121	0.027	1000.0	-1000.0	-0.103	-1000.0
Nectin adhesion pathway	3.0	192.0	63.0	-0.84	0.053	1000.0	-1000.0	-0.075	-1000.0
S1P5 pathway	3.0	61.0	17.0	-0.141	0.065	1000.0	-1000.0	-0.043	-1000.0
EPHB forward signaling	3.0	281.0	85.0	-0.101	0.053	1000.0	-1000.0	-0.093	-1000.0
Effects of Botulinum toxin	3.0	98.0	26.0	-0.079	0.025	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	393.0	125.0	-0.067	0.05	1000.0	-1000.0	-0.106	-1000.0
IL27-mediated signaling events	3.0	169.0	51.0	-0.351	0.054	1000.0	-1000.0	-0.088	-1000.0
LPA receptor mediated events	3.0	311.0	102.0	-0.268	0.036	1000.0	-1000.0	-0.1	-1000.0
EGFR-dependent Endothelin signaling events	3.0	75.0	21.0	-0.091	0.02	1000.0	-1000.0	-0.082	-1000.0
Thromboxane A2 receptor signaling	2.0	292.0	105.0	-0.203	0.1	1000.0	-1000.0	-0.075	-1000.0
Cellular roles of Anthrax toxin	2.0	81.0	39.0	-0.084	0.013	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by PTP1B	2.0	199.0	76.0	-0.475	0.083	1000.0	-1000.0	-0.09	-1000.0
PLK1 signaling events	2.0	182.0	85.0	-0.193	0.028	1000.0	-1000.0	-0.046	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	88.0	44.0	-0.048	0.013	1000.0	-1000.0	-0.048	-1000.0
Integrins in angiogenesis	2.0	228.0	84.0	-0.34	0.031	1000.0	-1000.0	-0.102	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	239.0	93.0	-0.122	0.038	1000.0	-1000.0	-0.086	-1000.0
Nongenotropic Androgen signaling	2.0	121.0	52.0	-0.141	0.027	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	2.0	164.0	75.0	-0.098	0.056	1000.0	-1000.0	-0.092	-1000.0
Plasma membrane estrogen receptor signaling	2.0	205.0	86.0	-0.255	0.036	1000.0	-1000.0	-0.091	-1000.0
VEGFR1 specific signals	2.0	159.0	56.0	-0.07	0.037	1000.0	-1000.0	-0.058	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	190.0	88.0	-0.301	0.104	1000.0	-1000.0	-0.11	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	75.0	33.0	-0.195	0.035	1000.0	-1000.0	-0.052	-1000.0
S1P4 pathway	2.0	55.0	25.0	-0.141	0.029	1000.0	-1000.0	-0.043	-1000.0
ErbB2/ErbB3 signaling events	1.0	113.0	65.0	-0.12	0.041	1000.0	-1000.0	-0.071	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	266.0	136.0	-0.213	0.212	1000.0	-1000.0	-0.075	-1000.0
Coregulation of Androgen receptor activity	1.0	124.0	76.0	-0.22	0.047	1000.0	-1000.0	-0.046	-1000.0
Arf6 signaling events	1.0	118.0	62.0	-0.119	0.028	1000.0	-1000.0	-0.059	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	92.0	85.0	-0.039	0.047	1000.0	-1000.0	-0.08	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	46.0	37.0	-0.141	0.043	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class III	1.0	47.0	40.0	-0.098	0.024	1000.0	-1000.0	-0.029	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	152.0	82.0	-0.121	0.013	1000.0	-1000.0	-0.093	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	76.0	52.0	-0.166	0.035	1000.0	-1000.0	-0.043	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	102.0	83.0	-0.299	0.069	1000.0	-1000.0	-0.077	-1000.0
FAS signaling pathway (CD95)	1.0	56.0	47.0	-0.06	0.028	1000.0	-1000.0	-0.059	-1000.0
Class I PI3K signaling events	1.0	74.0	73.0	-0.126	0.037	1000.0	-1000.0	-0.079	-1000.0
Regulation of Telomerase	1.0	182.0	102.0	-0.487	0.047	1000.0	-1000.0	-0.119	-1000.0
S1P3 pathway	1.0	70.0	42.0	-0.139	0.029	1000.0	-1000.0	-0.043	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	207.0	120.0	-0.104	0.07	1000.0	-1000.0	-0.078	-1000.0
PDGFR-beta signaling pathway	1.0	189.0	97.0	-0.2	0.044	1000.0	-1000.0	-0.095	-1000.0
E-cadherin signaling in keratinocytes	1.0	45.0	43.0	-0.227	0.051	1000.0	-1000.0	-0.054	-1000.0
FOXM1 transcription factor network	1.0	88.0	51.0	-0.231	0.048	1000.0	-1000.0	-0.227	-1000.0
Regulation of Androgen receptor activity	1.0	101.0	70.0	-0.268	0.04	1000.0	-1000.0	-0.068	-1000.0
Aurora B signaling	1.0	111.0	67.0	-0.339	0.072	1000.0	-1000.0	-0.06	-1000.0
LPA4-mediated signaling events	0.0	3.0	12.0	-0.068	0.017	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	2.0	23.0	0.003	0.042	1000.0	-1000.0	-0.06	-1000.0
Canonical NF-kappaB pathway	0.0	18.0	39.0	-0.07	0.063	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class II	0.0	13.0	75.0	-0.028	0.04	1000.0	-1000.0	-0.044	-1000.0
BARD1 signaling events	0.0	37.0	57.0	-0.027	0.047	1000.0	-1000.0	-0.068	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.013	0.021	1000.0	-1000.0	-0.027	-1000.0
Circadian rhythm pathway	0.0	7.0	22.0	-0.011	0.045	1000.0	-1000.0	-0.05	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.006	0.015	1000.0	-1000.0	-0.02	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	43.0	65.0	-0.14	0.058	1000.0	-1000.0	-0.072	-1000.0
Arf6 downstream pathway	0.0	12.0	43.0	-0.027	0.031	1000.0	-1000.0	-0.046	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.026	1000.0	-1000.0	-0.031	-1000.0
EPO signaling pathway	0.0	23.0	55.0	-0.005	0.065	1000.0	-1000.0	-0.1	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.004	0.04	1000.0	-1000.0	-0.056	-1000.0
PDGFR-alpha signaling pathway	0.0	14.0	44.0	-0.007	0.034	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	0.0	2.0	53.0	-0.0	0.037	1000.0	-1000.0	-0.066	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	6.0	68.0	-0.039	0.051	1000.0	-1000.0	-0.054	-1000.0
Ceramide signaling pathway	0.0	57.0	76.0	-0.089	0.049	1000.0	-1000.0	-0.058	-1000.0
TRAIL signaling pathway	0.0	29.0	48.0	-0.08	0.046	1000.0	-1000.0	-0.064	-1000.0
ceramide signaling pathway	0.0	3.0	49.0	0.0	0.052	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by HDAC Class I	0.0	7.0	104.0	-0.027	0.05	1000.0	-1000.0	-0.057	-1000.0
FoxO family signaling	0.0	23.0	64.0	-0.151	0.127	1000.0	-1000.0	-0.084	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	5.0	15.0	-0.038	0.026	1000.0	-1000.0	-0.039	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	3.0	36.0	-0.035	0.036	1000.0	-1000.0	-0.074	-1000.0
Atypical NF-kappaB pathway	0.0	2.0	31.0	-0.007	0.043	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by PI3K	0.0	22.0	58.0	-0.049	0.076	1000.0	-1000.0	-0.094	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	10.0	45.0	-0.004	0.072	1000.0	-1000.0	-0.107	-1000.0
Regulation of p38-alpha and p38-beta	0.0	43.0	54.0	-0.126	0.035	1000.0	-1000.0	-0.067	-1000.0
TCGA08_rtk_signaling	0.0	25.0	26.0	-0.039	0.042	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	50.0	74.0	-0.089	0.069	1000.0	-1000.0	-0.096	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	14.0	76.0	-0.016	0.057	1000.0	-1000.0	-0.091	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.002	0.035	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by STAT5	0.0	5.0	22.0	-0.007	0.06	1000.0	-1000.0	-0.064	-1000.0
Arf6 trafficking events	0.0	40.0	71.0	-0.037	0.04	1000.0	-1000.0	-0.077	-1000.0
IGF1 pathway	0.0	5.0	57.0	-0.036	0.04	1000.0	-1000.0	-0.104	-1000.0
Insulin Pathway	0.0	34.0	74.0	-0.094	0.037	1000.0	-1000.0	-0.105	-1000.0
Rapid glucocorticoid signaling	0.0	12.0	20.0	-0.01	0.018	1000.0	-1000.0	-0.027	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.013	0.013	1000.0	-1000.0	-0.013	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.013	0.028	1000.0	-1000.0	-0.021	-1000.0
p38 MAPK signaling pathway	0.0	29.0	44.0	-0.077	0.032	1000.0	-1000.0	-0.077	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.011	0.031	1000.0	-1000.0	-0.028	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.04	1000.0	-1000.0	-0.039	-1000.0
Total	446	26442	7203	-27.8906226301	7.102830875	131000	-131000	-9.36850656438	-131000