Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXM1 transcription factor network	73.0	3759.0	51.0	-0.754	0.015	1000.0	-1000.0	-0.127	-1000.0
Glypican 2 network	52.0	211.0	4.0	-0.116	-0.091	1000.0	-1000.0	-0.014	-1000.0
Aurora B signaling	52.0	3542.0	67.0	-0.493	0.015	1000.0	-1000.0	-0.052	-1000.0
Signaling events regulated by Ret tyrosine kinase	48.0	3941.0	82.0	-0.274	0.015	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	43.0	2933.0	68.0	-0.678	0.339	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by the Hedgehog family	39.0	2075.0	52.0	-0.181	0.179	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-alpha and p38-beta	37.0	1639.0	44.0	-0.201	0.015	1000.0	-1000.0	-0.043	-1000.0
IL4-mediated signaling events	36.0	3332.0	91.0	-0.816	0.565	1000.0	-1000.0	-0.109	-1000.0
Nongenotropic Androgen signaling	36.0	1906.0	52.0	-0.239	0.132	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	36.0	2094.0	57.0	-0.258	0.052	1000.0	-1000.0	-0.075	-1000.0
Reelin signaling pathway	34.0	1905.0	56.0	-0.214	0.037	1000.0	-1000.0	-0.072	-1000.0
Endothelins	32.0	3150.0	96.0	-0.316	0.063	1000.0	-1000.0	-0.056	-1000.0
TCGA08_retinoblastoma	32.0	258.0	8.0	-0.228	0.062	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	32.0	2562.0	78.0	-0.263	0.091	1000.0	-1000.0	-0.067	-1000.0
p75(NTR)-mediated signaling	31.0	3875.0	125.0	-0.167	0.044	1000.0	-1000.0	-0.075	-1000.0
TCGA08_p53	31.0	222.0	7.0	-0.157	0.072	1000.0	-1000.0	-0.016	-1000.0
Aurora C signaling	29.0	203.0	7.0	-0.189	0.0	1000.0	-1000.0	-0.025	-1000.0
Thromboxane A2 receptor signaling	28.0	2952.0	105.0	-0.19	0.034	1000.0	-1000.0	-0.055	-1000.0
Fc-epsilon receptor I signaling in mast cells	28.0	2722.0	97.0	-0.187	0.039	1000.0	-1000.0	-0.069	-1000.0
HIF-1-alpha transcription factor network	27.0	2068.0	76.0	-0.322	0.03	1000.0	-1000.0	-0.056	-1000.0
IL23-mediated signaling events	27.0	1678.0	60.0	-0.612	0.015	1000.0	-1000.0	-0.114	-1000.0
Ephrin A  reverse signaling	26.0	188.0	7.0	-0.075	-0.0	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	26.0	2255.0	85.0	-0.33	0.048	1000.0	-1000.0	-0.031	-1000.0
Calcium signaling in the CD4+ TCR pathway	26.0	819.0	31.0	-0.271	0.015	1000.0	-1000.0	-0.064	-1000.0
Plasma membrane estrogen receptor signaling	25.0	2202.0	86.0	-0.252	0.114	1000.0	-1000.0	-0.065	-1000.0
Ras signaling in the CD4+ TCR pathway	25.0	430.0	17.0	-0.152	0.02	1000.0	-1000.0	-0.021	-1000.0
amb2 Integrin signaling	24.0	2045.0	82.0	-0.333	0.02	1000.0	-1000.0	-0.058	-1000.0
Integrins in angiogenesis	24.0	2025.0	84.0	-0.265	0.03	1000.0	-1000.0	-0.077	-1000.0
BMP receptor signaling	23.0	1935.0	81.0	-0.305	0.048	1000.0	-1000.0	-0.074	-1000.0
Glypican 1 network	23.0	1124.0	48.0	-0.258	0.034	1000.0	-1000.0	-0.037	-1000.0
PDGFR-alpha signaling pathway	23.0	1051.0	44.0	-0.326	0.031	1000.0	-1000.0	-0.042	-1000.0
Rapid glucocorticoid signaling	23.0	471.0	20.0	-0.213	0.033	1000.0	-1000.0	-0.019	-1000.0
TCR signaling in naïve CD8+ T cells	22.0	2071.0	93.0	-0.127	0.065	1000.0	-1000.0	-0.059	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	22.0	2645.0	120.0	-0.327	0.191	1000.0	-1000.0	-0.059	-1000.0
Syndecan-1-mediated signaling events	21.0	746.0	34.0	-0.261	0.015	1000.0	-1000.0	-0.049	-1000.0
Glucocorticoid receptor regulatory network	21.0	2396.0	114.0	-0.6	0.269	1000.0	-1000.0	-0.061	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	21.0	1119.0	52.0	-0.297	0.028	1000.0	-1000.0	-0.031	-1000.0
LPA receptor mediated events	21.0	2158.0	102.0	-0.217	0.034	1000.0	-1000.0	-0.067	-1000.0
Visual signal transduction: Cones	20.0	776.0	38.0	-0.123	0.017	1000.0	-1000.0	-0.048	-1000.0
IL6-mediated signaling events	19.0	1425.0	75.0	-0.246	0.067	1000.0	-1000.0	-0.055	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	18.0	989.0	54.0	-0.179	0.029	1000.0	-1000.0	-0.081	-1000.0
S1P5 pathway	18.0	322.0	17.0	-0.152	0.106	1000.0	-1000.0	-0.024	-1000.0
S1P1 pathway	18.0	669.0	36.0	-0.259	0.016	1000.0	-1000.0	-0.047	-1000.0
LPA4-mediated signaling events	17.0	206.0	12.0	-0.165	0.021	1000.0	-1000.0	-0.011	-1000.0
Wnt signaling	17.0	123.0	7.0	-0.057	0.015	1000.0	-1000.0	-0.018	-1000.0
IL12-mediated signaling events	16.0	1428.0	87.0	-0.399	0.025	1000.0	-1000.0	-0.099	-1000.0
JNK signaling in the CD4+ TCR pathway	16.0	277.0	17.0	-0.155	0.016	1000.0	-1000.0	-0.028	-1000.0
BCR signaling pathway	16.0	1678.0	99.0	-0.188	0.034	1000.0	-1000.0	-0.074	-1000.0
S1P3 pathway	16.0	673.0	42.0	-0.151	0.029	1000.0	-1000.0	-0.033	-1000.0
Class IB PI3K non-lipid kinase events	16.0	48.0	3.0	-0.028	-1000.0	1000.0	-1000.0	-0.01	-1000.0
S1P4 pathway	16.0	419.0	25.0	-0.152	0.029	1000.0	-1000.0	-0.045	-1000.0
Coregulation of Androgen receptor activity	15.0	1197.0	76.0	-0.235	0.031	1000.0	-1000.0	-0.035	-1000.0
Osteopontin-mediated events	15.0	572.0	38.0	-0.178	0.015	1000.0	-1000.0	-0.08	-1000.0
Arf6 signaling events	15.0	963.0	62.0	-0.245	0.029	1000.0	-1000.0	-0.048	-1000.0
Aurora A signaling	15.0	933.0	60.0	-0.332	0.028	1000.0	-1000.0	-0.043	-1000.0
FAS signaling pathway (CD95)	14.0	667.0	47.0	-0.564	0.019	1000.0	-1000.0	-0.031	-1000.0
Syndecan-2-mediated signaling events	13.0	953.0	69.0	-0.091	0.034	1000.0	-1000.0	-0.035	-1000.0
Presenilin action in Notch and Wnt signaling	12.0	766.0	61.0	-0.172	0.042	1000.0	-1000.0	-0.057	-1000.0
Angiopoietin receptor Tie2-mediated signaling	12.0	1090.0	88.0	-0.243	0.059	1000.0	-1000.0	-0.091	-1000.0
Visual signal transduction: Rods	12.0	636.0	52.0	-0.196	0.015	1000.0	-1000.0	-0.072	-1000.0
Sphingosine 1-phosphate (S1P) pathway	11.0	316.0	28.0	-0.152	0.029	1000.0	-1000.0	-0.021	-1000.0
Syndecan-4-mediated signaling events	11.0	790.0	67.0	-0.179	0.021	1000.0	-1000.0	-0.083	-1000.0
ErbB2/ErbB3 signaling events	10.0	666.0	65.0	-0.238	0.025	1000.0	-1000.0	-0.06	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	10.0	365.0	34.0	-0.039	0.015	1000.0	-1000.0	-0.048	-1000.0
ErbB4 signaling events	10.0	690.0	69.0	-0.238	0.033	1000.0	-1000.0	-0.076	-1000.0
Noncanonical Wnt signaling pathway	10.0	282.0	26.0	-0.088	0.015	1000.0	-1000.0	-0.043	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	904.0	85.0	-0.209	0.022	1000.0	-1000.0	-0.055	-1000.0
Canonical Wnt signaling pathway	10.0	522.0	51.0	-0.171	0.078	1000.0	-1000.0	-0.042	-1000.0
Effects of Botulinum toxin	10.0	272.0	26.0	-0.072	0.015	1000.0	-1000.0	-0.046	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	10.0	349.0	33.0	-0.279	0.043	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	9.0	660.0	70.0	-0.251	0.029	1000.0	-1000.0	-0.05	-1000.0
Caspase cascade in apoptosis	8.0	626.0	74.0	-0.04	0.043	1000.0	-1000.0	-0.024	-1000.0
Hedgehog signaling events mediated by Gli proteins	8.0	533.0	65.0	-0.152	0.061	1000.0	-1000.0	-0.07	-1000.0
Nectin adhesion pathway	8.0	517.0	63.0	-0.044	0.029	1000.0	-1000.0	-0.06	-1000.0
IL27-mediated signaling events	8.0	426.0	51.0	-0.247	0.018	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by STAT5	8.0	192.0	22.0	-0.124	0.062	1000.0	-1000.0	-0.02	-1000.0
EGFR-dependent Endothelin signaling events	8.0	177.0	21.0	-0.062	0.022	1000.0	-1000.0	-0.057	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	958.0	136.0	-0.179	0.065	1000.0	-1000.0	-0.055	-1000.0
IL1-mediated signaling events	7.0	450.0	62.0	-0.102	0.071	1000.0	-1000.0	-0.082	-1000.0
Cellular roles of Anthrax toxin	6.0	234.0	39.0	-0.093	0.019	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	6.0	481.0	76.0	-0.133	0.036	1000.0	-1000.0	-0.065	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	320.0	46.0	-0.197	0.112	1000.0	-1000.0	-0.041	-1000.0
Ephrin B reverse signaling	6.0	289.0	48.0	-0.041	0.019	1000.0	-1000.0	-0.057	-1000.0
IL2 signaling events mediated by PI3K	6.0	387.0	58.0	-0.18	0.05	1000.0	-1000.0	-0.062	-1000.0
Regulation of p38-alpha and p38-beta	6.0	329.0	54.0	-0.147	0.038	1000.0	-1000.0	-0.043	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	29.0	5.0	-0.003	0.009	1000.0	-1000.0	-0.016	-1000.0
Class I PI3K signaling events mediated by Akt	5.0	365.0	68.0	-0.215	0.056	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class III	5.0	219.0	40.0	-0.213	0.024	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	464.0	83.0	-0.259	0.04	1000.0	-1000.0	-0.062	-1000.0
Regulation of Telomerase	5.0	512.0	102.0	-0.162	0.037	1000.0	-1000.0	-0.093	-1000.0
Insulin Pathway	5.0	380.0	74.0	-0.265	0.04	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by PRL	5.0	173.0	34.0	-0.097	0.025	1000.0	-1000.0	-0.021	-1000.0
BARD1 signaling events	4.0	282.0	57.0	-0.137	0.045	1000.0	-1000.0	-0.052	-1000.0
IFN-gamma pathway	4.0	278.0	68.0	-0.164	0.056	1000.0	-1000.0	-0.081	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	178.0	37.0	-0.031	0.036	1000.0	-1000.0	-0.047	-1000.0
TRAIL signaling pathway	4.0	195.0	48.0	-0.013	0.045	1000.0	-1000.0	-0.054	-1000.0
Syndecan-3-mediated signaling events	4.0	155.0	35.0	-0.134	0.044	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	194.0	45.0	-0.033	0.065	1000.0	-1000.0	-0.071	-1000.0
EPHB forward signaling	4.0	374.0	85.0	-0.038	0.042	1000.0	-1000.0	-0.074	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	366.0	74.0	-0.252	0.074	1000.0	-1000.0	-0.069	-1000.0
Arf6 trafficking events	4.0	295.0	71.0	-0.419	0.048	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling events	4.0	22.0	5.0	-0.004	0.017	1000.0	-1000.0	-0.016	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	0.004	0.017	1000.0	-1000.0	-0.01	-1000.0
EPO signaling pathway	3.0	218.0	55.0	-0.046	0.05	1000.0	-1000.0	-0.076	-1000.0
Ceramide signaling pathway	3.0	250.0	76.0	-0.252	0.042	1000.0	-1000.0	-0.034	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	59.0	15.0	0.0	0.031	1000.0	-1000.0	-0.021	-1000.0
Retinoic acid receptors-mediated signaling	3.0	175.0	58.0	-0.078	0.033	1000.0	-1000.0	-0.063	-1000.0
TCGA08_rtk_signaling	3.0	86.0	26.0	-0.075	0.044	1000.0	-1000.0	-0.019	-1000.0
PDGFR-beta signaling pathway	3.0	369.0	97.0	-0.059	0.057	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class II	2.0	161.0	75.0	-0.08	0.037	1000.0	-1000.0	-0.035	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	199.0	76.0	-0.015	0.056	1000.0	-1000.0	-0.068	-1000.0
Class I PI3K signaling events	2.0	159.0	73.0	-0.056	0.037	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in keratinocytes	2.0	109.0	43.0	-0.044	0.046	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	2.0	97.0	44.0	-0.035	0.044	1000.0	-1000.0	-0.051	-1000.0
Canonical NF-kappaB pathway	1.0	64.0	39.0	-0.026	0.087	1000.0	-1000.0	-0.063	-1000.0
Insulin-mediated glucose transport	1.0	44.0	32.0	-0.145	0.038	1000.0	-1000.0	-0.048	-1000.0
ceramide signaling pathway	1.0	68.0	49.0	-0.024	0.048	1000.0	-1000.0	-0.032	-1000.0
HIF-2-alpha transcription factor network	1.0	44.0	43.0	-0.154	0.157	1000.0	-1000.0	-0.059	-1000.0
FoxO family signaling	1.0	95.0	64.0	-0.077	0.097	1000.0	-1000.0	-0.05	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	62.0	36.0	-0.033	0.035	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	130.0	125.0	-0.041	0.097	1000.0	-1000.0	-0.077	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	10.0	23.0	0.004	0.051	1000.0	-1000.0	-0.036	-1000.0
Circadian rhythm pathway	0.0	20.0	22.0	-0.015	0.049	1000.0	-1000.0	-0.032	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.036	0.037	1000.0	-1000.0	-0.034	-1000.0
mTOR signaling pathway	0.0	50.0	53.0	-0.006	0.039	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class I	0.0	62.0	104.0	-0.009	0.063	1000.0	-1000.0	-0.055	-1000.0
Atypical NF-kappaB pathway	0.0	22.0	31.0	-0.0	0.052	1000.0	-1000.0	-0.03	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.0	0.036	1000.0	-1000.0	-0.043	-1000.0
VEGFR1 specific signals	0.0	48.0	56.0	-0.048	0.069	1000.0	-1000.0	-0.033	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.0	0.037	1000.0	-1000.0	-0.03	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.044	1000.0	-1000.0	-0.024	-1000.0
Total	1847	108365	7203	-23.4206656112	-993.409111654	131000	-131000	-6.67518914423	-131000