Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	30.0	1809.0	60.0	-0.629	0.012	1000.0	-1000.0	-0.158	-1000.0
HIF-1-alpha transcription factor network	26.0	2041.0	76.0	-0.549	0.02	1000.0	-1000.0	-0.141	-1000.0
Signaling mediated by p38-alpha and p38-beta	24.0	1082.0	44.0	-0.221	0.012	1000.0	-1000.0	-0.052	-1000.0
IL4-mediated signaling events	23.0	2094.0	91.0	-0.808	0.689	1000.0	-1000.0	-0.17	-1000.0
p75(NTR)-mediated signaling	22.0	2837.0	125.0	-0.236	0.033	1000.0	-1000.0	-0.104	-1000.0
Signaling events mediated by the Hedgehog family	20.0	1052.0	52.0	-0.254	0.072	1000.0	-1000.0	-0.052	-1000.0
Syndecan-1-mediated signaling events	19.0	669.0	34.0	-0.186	0.012	1000.0	-1000.0	-0.052	-1000.0
Wnt signaling	18.0	126.0	7.0	-0.09	0.012	1000.0	-1000.0	-0.028	-1000.0
BMP receptor signaling	17.0	1415.0	81.0	-0.256	0.026	1000.0	-1000.0	-0.088	-1000.0
Glypican 1 network	16.0	803.0	48.0	-0.156	0.02	1000.0	-1000.0	-0.04	-1000.0
Glucocorticoid receptor regulatory network	16.0	1923.0	114.0	-0.665	0.311	1000.0	-1000.0	-0.08	-1000.0
Glypican 2 network	16.0	67.0	4.0	-0.063	-0.049	1000.0	-1000.0	-0.023	-1000.0
IL12-mediated signaling events	15.0	1364.0	87.0	-0.317	0.098	1000.0	-1000.0	-0.135	-1000.0
FOXA2 and FOXA3 transcription factor networks	15.0	713.0	46.0	-0.384	0.019	1000.0	-1000.0	-0.119	-1000.0
TCR signaling in naïve CD8+ T cells	15.0	1471.0	93.0	-0.166	0.091	1000.0	-1000.0	-0.08	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	15.0	1813.0	120.0	-0.291	0.214	1000.0	-1000.0	-0.072	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	13.0	472.0	34.0	-0.086	0.012	1000.0	-1000.0	-0.05	-1000.0
Syndecan-2-mediated signaling events	13.0	914.0	69.0	-0.129	0.016	1000.0	-1000.0	-0.036	-1000.0
Ephrin B reverse signaling	13.0	662.0	48.0	-0.109	0.063	1000.0	-1000.0	-0.058	-1000.0
Endothelins	13.0	1322.0	96.0	-0.229	0.028	1000.0	-1000.0	-0.084	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	13.0	931.0	68.0	-0.32	0.071	1000.0	-1000.0	-0.12	-1000.0
BCR signaling pathway	13.0	1374.0	99.0	-0.179	0.028	1000.0	-1000.0	-0.087	-1000.0
amb2 Integrin signaling	12.0	1063.0	82.0	-0.148	0.014	1000.0	-1000.0	-0.076	-1000.0
Syndecan-4-mediated signaling events	12.0	846.0	67.0	-0.157	0.023	1000.0	-1000.0	-0.091	-1000.0
Integrins in angiogenesis	11.0	996.0	84.0	-0.179	0.019	1000.0	-1000.0	-0.092	-1000.0
EGFR-dependent Endothelin signaling events	11.0	241.0	21.0	-0.093	0.019	1000.0	-1000.0	-0.065	-1000.0
ErbB4 signaling events	10.0	706.0	69.0	-0.181	0.066	1000.0	-1000.0	-0.084	-1000.0
Noncanonical Wnt signaling pathway	10.0	261.0	26.0	-0.09	0.012	1000.0	-1000.0	-0.06	-1000.0
Thromboxane A2 receptor signaling	10.0	1095.0	105.0	-0.097	0.026	1000.0	-1000.0	-0.057	-1000.0
Fc-epsilon receptor I signaling in mast cells	10.0	1013.0	97.0	-0.132	0.03	1000.0	-1000.0	-0.086	-1000.0
Nectin adhesion pathway	10.0	664.0	63.0	-0.099	0.022	1000.0	-1000.0	-0.069	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	894.0	82.0	-0.129	0.012	1000.0	-1000.0	-0.083	-1000.0
EPHB forward signaling	10.0	912.0	85.0	-0.117	0.095	1000.0	-1000.0	-0.083	-1000.0
Effects of Botulinum toxin	10.0	279.0	26.0	-0.17	0.012	1000.0	-1000.0	-0.064	-1000.0
Calcium signaling in the CD4+ TCR pathway	10.0	315.0	31.0	-0.227	0.013	1000.0	-1000.0	-0.089	-1000.0
IL27-mediated signaling events	10.0	526.0	51.0	-0.147	0.081	1000.0	-1000.0	-0.078	-1000.0
IGF1 pathway	10.0	619.0	57.0	-0.109	0.025	1000.0	-1000.0	-0.095	-1000.0
Plasma membrane estrogen receptor signaling	10.0	889.0	86.0	-0.105	0.057	1000.0	-1000.0	-0.081	-1000.0
Class IB PI3K non-lipid kinase events	10.0	30.0	3.0	-0.025	-1000.0	1000.0	-1000.0	-0.011	-1000.0
Ephrin A  reverse signaling	9.0	68.0	7.0	-0.016	-0.0	1000.0	-1000.0	-0.022	-1000.0
Arf6 signaling events	9.0	587.0	62.0	-0.104	0.018	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	9.0	160.0	17.0	-0.095	0.071	1000.0	-1000.0	-0.031	-1000.0
LPA receptor mediated events	9.0	924.0	102.0	-0.114	0.021	1000.0	-1000.0	-0.089	-1000.0
TCGA08_retinoblastoma	9.0	73.0	8.0	-0.013	0.017	1000.0	-1000.0	-0.017	-1000.0
LPA4-mediated signaling events	8.0	98.0	12.0	-0.077	0.018	1000.0	-1000.0	-0.026	-1000.0
Caspase cascade in apoptosis	8.0	655.0	74.0	-0.088	0.031	1000.0	-1000.0	-0.039	-1000.0
Coregulation of Androgen receptor activity	8.0	661.0	76.0	-0.186	0.024	1000.0	-1000.0	-0.04	-1000.0
Osteopontin-mediated events	8.0	324.0	38.0	-0.112	0.012	1000.0	-1000.0	-0.097	-1000.0
Signaling events mediated by PTP1B	8.0	637.0	76.0	-0.182	0.02	1000.0	-1000.0	-0.08	-1000.0
PDGFR-alpha signaling pathway	8.0	352.0	44.0	-0.087	0.022	1000.0	-1000.0	-0.061	-1000.0
Reelin signaling pathway	8.0	487.0	56.0	-0.156	0.019	1000.0	-1000.0	-0.078	-1000.0
IL1-mediated signaling events	8.0	523.0	62.0	-0.159	0.057	1000.0	-1000.0	-0.098	-1000.0
Nongenotropic Androgen signaling	8.0	451.0	52.0	-0.099	0.015	1000.0	-1000.0	-0.055	-1000.0
IL6-mediated signaling events	8.0	666.0	75.0	-0.135	0.046	1000.0	-1000.0	-0.093	-1000.0
Visual signal transduction: Rods	8.0	420.0	52.0	-0.167	0.012	1000.0	-1000.0	-0.079	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	439.0	61.0	-0.156	0.03	1000.0	-1000.0	-0.078	-1000.0
Canonical Wnt signaling pathway	7.0	377.0	51.0	-0.156	0.069	1000.0	-1000.0	-0.059	-1000.0
Angiopoietin receptor Tie2-mediated signaling	7.0	652.0	88.0	-0.145	0.025	1000.0	-1000.0	-0.096	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	576.0	78.0	-0.072	0.041	1000.0	-1000.0	-0.075	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	195.0	28.0	-0.095	0.031	1000.0	-1000.0	-0.029	-1000.0
Visual signal transduction: Cones	6.0	243.0	38.0	-0.063	0.012	1000.0	-1000.0	-0.06	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	111.0	17.0	-0.042	0.013	1000.0	-1000.0	-0.044	-1000.0
Cellular roles of Anthrax toxin	6.0	257.0	39.0	-0.076	0.014	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	390.0	65.0	-0.339	0.036	1000.0	-1000.0	-0.067	-1000.0
IFN-gamma pathway	6.0	420.0	68.0	-0.132	0.02	1000.0	-1000.0	-0.093	-1000.0
TRAIL signaling pathway	6.0	296.0	48.0	-0.037	0.019	1000.0	-1000.0	-0.062	-1000.0
S1P1 pathway	6.0	227.0	36.0	-0.099	0.012	1000.0	-1000.0	-0.054	-1000.0
Syndecan-3-mediated signaling events	6.0	227.0	35.0	-0.175	0.033	1000.0	-1000.0	-0.044	-1000.0
S1P4 pathway	6.0	157.0	25.0	-0.095	0.019	1000.0	-1000.0	-0.035	-1000.0
Regulation of Androgen receptor activity	6.0	466.0	70.0	-0.276	0.025	1000.0	-1000.0	-0.066	-1000.0
BARD1 signaling events	5.0	298.0	57.0	-0.047	0.035	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by STAT5	5.0	111.0	22.0	-0.042	0.026	1000.0	-1000.0	-0.058	-1000.0
Regulation of Telomerase	5.0	512.0	102.0	-0.129	0.037	1000.0	-1000.0	-0.111	-1000.0
S1P3 pathway	5.0	236.0	42.0	-0.056	0.021	1000.0	-1000.0	-0.035	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	93.0	17.0	-0.03	0.021	1000.0	-1000.0	-0.043	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	592.0	136.0	-0.16	0.066	1000.0	-1000.0	-0.071	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	21.0	5.0	-0.007	0.004	1000.0	-1000.0	-0.02	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	420.0	85.0	-0.053	0.017	1000.0	-1000.0	-0.076	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	169.0	37.0	-0.05	0.021	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class III	4.0	163.0	40.0	-0.165	0.019	1000.0	-1000.0	-0.047	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	230.0	52.0	-0.096	0.033	1000.0	-1000.0	-0.053	-1000.0
FAS signaling pathway (CD95)	4.0	193.0	47.0	-0.066	0.015	1000.0	-1000.0	-0.047	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	60.0	15.0	-0.013	0.024	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	4.0	248.0	58.0	-0.08	0.025	1000.0	-1000.0	-0.075	-1000.0
IL2 signaling events mediated by PI3K	4.0	288.0	58.0	-0.061	0.023	1000.0	-1000.0	-0.093	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	189.0	45.0	-0.072	0.035	1000.0	-1000.0	-0.095	-1000.0
Class I PI3K signaling events	4.0	294.0	73.0	-0.082	0.024	1000.0	-1000.0	-0.062	-1000.0
ErbB2/ErbB3 signaling events	3.0	256.0	65.0	-0.106	0.022	1000.0	-1000.0	-0.065	-1000.0
PLK2 and PLK4 events	3.0	10.0	3.0	-0.005	0.012	1000.0	-1000.0	-0.018	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	209.0	54.0	-0.069	0.025	1000.0	-1000.0	-0.092	-1000.0
Ceramide signaling pathway	3.0	298.0	76.0	-0.105	0.035	1000.0	-1000.0	-0.043	-1000.0
HIF-2-alpha transcription factor network	3.0	130.0	43.0	-0.082	0.084	1000.0	-1000.0	-0.078	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.01	0.012	1000.0	-1000.0	-0.014	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	114.0	36.0	-0.05	0.027	1000.0	-1000.0	-0.074	-1000.0
TCGA08_rtk_signaling	3.0	81.0	26.0	-0.039	0.039	1000.0	-1000.0	-0.026	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	237.0	74.0	-0.184	0.061	1000.0	-1000.0	-0.087	-1000.0
Insulin Pathway	3.0	257.0	74.0	-0.145	0.026	1000.0	-1000.0	-0.085	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	3.0	127.0	33.0	-0.115	0.027	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	3.0	74.0	20.0	-0.039	0.015	1000.0	-1000.0	-0.022	-1000.0
PDGFR-beta signaling pathway	3.0	343.0	97.0	-0.059	0.034	1000.0	-1000.0	-0.077	-1000.0
FOXM1 transcription factor network	3.0	175.0	51.0	-0.1	0.132	1000.0	-1000.0	-0.188	-1000.0
p38 MAPK signaling pathway	3.0	134.0	44.0	-0.121	0.024	1000.0	-1000.0	-0.068	-1000.0
Aurora A signaling	2.0	155.0	60.0	-0.133	0.037	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	2.0	137.0	55.0	-0.028	0.048	1000.0	-1000.0	-0.089	-1000.0
mTOR signaling pathway	2.0	125.0	53.0	-0.019	0.021	1000.0	-1000.0	-0.063	-1000.0
ceramide signaling pathway	2.0	102.0	49.0	-0.044	0.029	1000.0	-1000.0	-0.045	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	166.0	83.0	-0.077	0.052	1000.0	-1000.0	-0.074	-1000.0
Regulation of p38-alpha and p38-beta	2.0	141.0	54.0	-0.082	0.032	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	373.0	125.0	-0.081	0.045	1000.0	-1000.0	-0.089	-1000.0
VEGFR1 specific signals	2.0	128.0	56.0	-0.025	0.028	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by PRL	2.0	96.0	34.0	-0.103	0.031	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	31.0	23.0	-0.035	0.039	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	1.0	66.0	39.0	-0.045	0.065	1000.0	-1000.0	-0.081	-1000.0
Signaling events mediated by HDAC Class II	1.0	138.0	75.0	-0.067	0.033	1000.0	-1000.0	-0.046	-1000.0
Circadian rhythm pathway	1.0	28.0	22.0	-0.016	0.04	1000.0	-1000.0	-0.047	-1000.0
Arf6 downstream pathway	1.0	59.0	43.0	-0.018	0.025	1000.0	-1000.0	-0.033	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.002	0.015	1000.0	-1000.0	-0.029	-1000.0
Insulin-mediated glucose transport	1.0	39.0	32.0	-0.031	0.04	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by HDAC Class I	1.0	123.0	104.0	-0.045	0.046	1000.0	-1000.0	-0.065	-1000.0
FoxO family signaling	1.0	91.0	64.0	-0.071	0.122	1000.0	-1000.0	-0.078	-1000.0
Atypical NF-kappaB pathway	1.0	42.0	31.0	-0.016	0.042	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	82.0	76.0	-0.027	0.055	1000.0	-1000.0	-0.081	-1000.0
Aurora B signaling	1.0	100.0	67.0	-0.075	0.033	1000.0	-1000.0	-0.066	-1000.0
PLK1 signaling events	0.0	69.0	85.0	-0.014	0.033	1000.0	-1000.0	-0.044	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	66.0	68.0	-0.032	0.042	1000.0	-1000.0	-0.043	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.0	0.031	1000.0	-1000.0	-0.054	-1000.0
Arf6 trafficking events	0.0	60.0	71.0	-0.028	0.04	1000.0	-1000.0	-0.073	-1000.0
E-cadherin signaling in keratinocytes	0.0	28.0	43.0	-0.039	0.038	1000.0	-1000.0	-0.068	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.012	0.025	1000.0	-1000.0	-0.026	-1000.0
Arf1 pathway	0.0	28.0	54.0	-0.014	0.025	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	4.0	13.0	-0.0	0.035	1000.0	-1000.0	-0.04	-1000.0
Total	936	59495	7203	-15.8745989695	-994.685743736	131000	-131000	-8.59632172686	-131000