Association of mutation, copy number alteration, and subtype markers with pathways
Glioblastoma Multiforme (Primary solid tumor)
15 January 2014
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analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by Spring Yingchun Liu
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
Association of mutation, copy number alteration, and subtype markers with pathways.
Broad Institute of MIT and Harvard.
doi:10.7908/C15T3HXB
Overview
Introduction
Summary
There are 10 genes with significant mutation (Q value <= 0.1) and 137 genes with significant copy number alteration (Q value <= 0.25). The identified marker genes (Q value <= 0.01 or within top 2000) are 2000 for subtype 1, 2000 for subtype 2, 2000 for subtype 3. Pathways significantly enriched with these genes (Q value <= 0.01) are identified :
83 pathways significantly enriched with genes with copy number alteration or mutation.
55 pathways significantly enriched with marker genes of gene expression subtype 1
7 pathways significantly enriched with marker genes of gene expression subtype 2
8 pathways significantly enriched with marker genes of gene expression subtype 3
Results
The top five pathways enriched with genes with copy number alteration or mutation
The top five pathways enriched with marker genes of gene expression subtype 1
The top five pathways enriched with marker genes of gene expression subtype 2
The top five pathways enriched with marker genes of gene expression subtype 3
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
All rights reserved.