E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.017 0.184 -9999.0 0.0 -0.592 15.0 15.0 KLHL20 -0.016 0.05 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.022 0.121 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.017 0.184 -9999.0 0.0 -0.592 15.0 15.0 AP1M1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.088 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.033 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.049 0.153 -9999.0 0.0 -0.528 15.0 15.0 RAPGEF1 0.002 0.159 -9999.0 0.0 -0.495 15.0 15.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.057 0.179 -9999.0 0.0 -0.615 15.0 15.0 CRK -0.007 0.173 -9999.0 0.0 -0.546 15.0 15.0 E-cadherin/gamma catenin/alpha catenin -0.054 0.168 -9999.0 0.0 -0.578 15.0 15.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.017 0.184 -9999.0 0.0 -0.592 15.0 15.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.02 0.063 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.003 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.026 0.081 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.062 0.193 -9999.0 0.0 -0.665 15.0 15.0 TIAM1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.047 0.146 -9999.0 0.0 -0.502 15.0 15.0 AKT1 -0.015 0.045 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.069 0.253 -9999.0 0.0 -0.859 15.0 15.0 RhoA/GDP 0.021 0.121 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.012 0.037 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GDP 0.021 0.121 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.011 0.11 -9999.0 0.0 -0.355 15.0 15.0 ITGB7 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.049 0.153 -9999.0 0.0 -0.528 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.047 0.148 -9999.0 0.0 -0.509 15.0 15.0 mol:GDP 0.013 0.141 -9999.0 0.0 -0.426 15.0 15.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.034 0.106 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.025 0.034 -9999.0 0.0 -9999.0 0.0 0.0 NME1 0.006 0.047 -9999.0 0.0 -0.336 3.0 3.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.017 0.184 -9999.0 0.0 -0.592 15.0 15.0 regulation of cell-cell adhesion -0.025 0.077 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.032 0.101 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.144 -9999.0 0.0 -0.495 15.0 15.0 CCND1 0.029 0.04 -9999.0 0.0 -9999.0 0.0 0.0 VAV2 -0.001 0.166 -9999.0 0.0 -0.519 15.0 15.0 RAP1/GDP -0.032 0.101 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.016 0.177 -9999.0 0.0 -0.569 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.044 0.137 -9999.0 0.0 -0.47 15.0 15.0 E-cadherin/beta catenin -0.048 0.151 -9999.0 0.0 -0.518 15.0 15.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.017 0.184 -9999.0 0.0 -0.591 15.0 15.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.026 0.079 -9999.0 0.0 -0.334 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.054 0.168 -9999.0 0.0 -0.578 15.0 15.0 ITGAE 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.059 0.184 -9999.0 0.0 -0.632 15.0 15.0