Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.01 0.172 -9999.0 0.0 -0.647 2.0 2.0 IHH -0.086 0.29 -9999.0 0.0 -0.876 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.023 0.103 -9999.0 0.0 -0.535 6.0 6.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.023 0.102 0.531 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.014 0.191 -9999.0 0.0 -0.506 20.0 20.0 SMO -0.021 0.201 -9999.0 0.0 -0.539 20.0 20.0 AKT1 0.015 0.09 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.02 0.198 -9999.0 0.0 -0.53 20.0 20.0 STIL -0.01 0.159 -9999.0 0.0 -0.485 7.0 7.0 DHH N/PTCH2 -0.034 0.145 -9999.0 0.0 -0.665 8.0 8.0 DHH N/PTCH1 -0.046 0.205 -9999.0 0.0 -0.5 26.0 26.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.032 0.189 -9999.0 0.0 -0.859 8.0 8.0 PTHLH -0.02 0.201 -9999.0 0.0 -0.829 2.0 2.0 determination of left/right symmetry -0.02 0.198 -9999.0 0.0 -0.53 20.0 20.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.019 0.2 -9999.0 0.0 -0.819 2.0 2.0 IHH N/Hhip -0.089 0.246 -9999.0 0.0 -0.631 27.0 27.0 DHH N/Hhip -0.067 0.217 -9999.0 0.0 -0.742 14.0 14.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.02 0.198 -9999.0 0.0 -0.53 20.0 20.0 pancreas development -0.036 0.192 -9999.0 0.0 -0.753 10.0 10.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.009 0.136 -9999.0 0.0 -0.859 4.0 4.0 somite specification -0.02 0.198 -9999.0 0.0 -0.53 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.016 0.16 -9999.0 0.0 -0.502 5.0 5.0 SHH Np/Cholesterol/PTCH2 -0.01 0.063 -9999.0 0.0 -0.534 2.0 2.0 SHH Np/Cholesterol/Megalin -0.079 0.198 -9999.0 0.0 -0.565 22.0 22.0 SHH 0.009 0.083 -9999.0 0.0 -0.666 2.0 2.0 catabolic process -0.024 0.184 -9999.0 0.0 -0.519 19.0 19.0 SMO/Vitamin D3 -0.017 0.18 -9999.0 0.0 -0.606 4.0 4.0 SHH Np/Cholesterol/Hhip -0.038 0.132 -9999.0 0.0 -0.536 10.0 10.0 LRP2 -0.101 0.293 -9999.0 0.0 -0.859 21.0 21.0 receptor-mediated endocytosis -0.103 0.222 -9999.0 0.0 -0.725 13.0 13.0 SHH Np/Cholesterol/BOC -0.01 0.062 -9999.0 0.0 -0.534 2.0 2.0 SHH Np/Cholesterol/CDO -0.013 0.066 -9999.0 0.0 -0.534 2.0 2.0 mesenchymal cell differentiation 0.038 0.131 0.531 10.0 -9999.0 0.0 10.0 mol:Vitamin D3 -0.013 0.163 -9999.0 0.0 -0.504 5.0 5.0 IHH N/PTCH2 -0.05 0.197 -9999.0 0.0 -0.585 19.0 19.0 CDON 0.004 0.054 -9999.0 0.0 -0.336 4.0 4.0 IHH N/PTCH1 -0.025 0.187 -9999.0 0.0 -0.527 19.0 19.0 Megalin/LRPAP1 -0.087 0.224 -9999.0 0.0 -0.665 21.0 21.0 PTCH2 0.01 0.027 -9999.0 0.0 -0.336 1.0 1.0 SHH Np/Cholesterol -0.01 0.064 -9999.0 0.0 -0.542 2.0 2.0 PTCH1 -0.024 0.185 -9999.0 0.0 -0.521 19.0 19.0 HHIP -0.036 0.192 -9999.0 0.0 -0.754 10.0 10.0