Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	76.0	2604.0	34.0	-0.674	0.012	1000.0	-1000.0	-0.053	-1000.0
EGFR-dependent Endothelin signaling events	61.0	1292.0	21.0	-0.756	0.012	1000.0	-1000.0	-0.07	-1000.0
Angiopoietin receptor Tie2-mediated signaling	46.0	4101.0	88.0	-0.903	0.075	1000.0	-1000.0	-0.123	-1000.0
FOXA2 and FOXA3 transcription factor networks	43.0	1978.0	46.0	-1.289	0.019	1000.0	-1000.0	-0.104	-1000.0
Glypican 2 network	36.0	147.0	4.0	-0.133	-1000.0	1000.0	-1000.0	-0.036	-1000.0
PDGFR-alpha signaling pathway	31.0	1405.0	44.0	-0.327	0.028	1000.0	-1000.0	-0.068	-1000.0
Thromboxane A2 receptor signaling	26.0	2744.0	105.0	-0.756	0.073	1000.0	-1000.0	-0.075	-1000.0
Glypican 1 network	24.0	1192.0	48.0	-0.472	0.033	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	22.0	1400.0	62.0	-0.756	0.015	1000.0	-1000.0	-0.063	-1000.0
amb2 Integrin signaling	20.0	1640.0	82.0	-0.544	0.012	1000.0	-1000.0	-0.079	-1000.0
TCGA08_retinoblastoma	19.0	156.0	8.0	-0.26	0.069	1000.0	-1000.0	-0.019	-1000.0
FOXM1 transcription factor network	19.0	982.0	51.0	-0.27	0.024	1000.0	-1000.0	-0.18	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	18.0	1476.0	78.0	-0.319	0.062	1000.0	-1000.0	-0.081	-1000.0
BMP receptor signaling	17.0	1427.0	81.0	-0.526	0.012	1000.0	-1000.0	-0.101	-1000.0
Endothelins	17.0	1644.0	96.0	-0.609	0.012	1000.0	-1000.0	-0.09	-1000.0
TCGA08_p53	17.0	125.0	7.0	-0.176	0.106	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	757.0	44.0	-0.152	0.012	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	17.0	2137.0	125.0	-0.173	0.014	1000.0	-1000.0	-0.097	-1000.0
IL4-mediated signaling events	14.0	1361.0	91.0	-0.913	0.498	1000.0	-1000.0	-0.168	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	14.0	996.0	68.0	-0.604	0.08	1000.0	-1000.0	-0.125	-1000.0
Signaling events mediated by PTP1B	13.0	1036.0	76.0	-0.76	0.1	1000.0	-1000.0	-0.082	-1000.0
Integrins in angiogenesis	13.0	1143.0	84.0	-0.563	0.033	1000.0	-1000.0	-0.091	-1000.0
S1P1 pathway	12.0	464.0	36.0	-0.156	0.012	1000.0	-1000.0	-0.06	-1000.0
Effects of Botulinum toxin	12.0	313.0	26.0	-0.242	0.015	1000.0	-1000.0	-0.071	-1000.0
Aurora B signaling	12.0	864.0	67.0	-0.279	0.012	1000.0	-1000.0	-0.07	-1000.0
Aurora C signaling	11.0	77.0	7.0	-0.154	0.012	1000.0	-1000.0	-0.043	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1088.0	93.0	-0.568	0.261	1000.0	-1000.0	-0.082	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	886.0	74.0	-0.756	0.049	1000.0	-1000.0	-0.095	-1000.0
Syndecan-4-mediated signaling events	11.0	743.0	67.0	-0.508	0.084	1000.0	-1000.0	-0.1	-1000.0
FoxO family signaling	10.0	661.0	64.0	-0.987	0.084	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1318.0	120.0	-0.345	0.158	1000.0	-1000.0	-0.091	-1000.0
Syndecan-1-mediated signaling events	9.0	328.0	34.0	-0.123	0.012	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by the Hedgehog family	9.0	473.0	52.0	-0.103	0.038	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling events	9.0	45.0	5.0	-0.069	0.012	1000.0	-1000.0	-0.046	-1000.0
Coregulation of Androgen receptor activity	8.0	609.0	76.0	-0.797	0.023	1000.0	-1000.0	-0.055	-1000.0
IL27-mediated signaling events	8.0	429.0	51.0	-0.986	0.139	1000.0	-1000.0	-0.097	-1000.0
LPA4-mediated signaling events	7.0	95.0	12.0	-0.233	0.019	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	7.0	483.0	69.0	-0.383	0.116	1000.0	-1000.0	-0.084	-1000.0
HIF-1-alpha transcription factor network	7.0	539.0	76.0	-0.16	0.052	1000.0	-1000.0	-0.141	-1000.0
p75(NTR)-mediated signaling	7.0	938.0	125.0	-0.517	0.035	1000.0	-1000.0	-0.11	-1000.0
Glucocorticoid receptor regulatory network	7.0	858.0	114.0	-0.602	0.16	1000.0	-1000.0	-0.078	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	628.0	82.0	-0.127	0.012	1000.0	-1000.0	-0.088	-1000.0
Nongenotropic Androgen signaling	7.0	406.0	52.0	-0.093	0.024	1000.0	-1000.0	-0.062	-1000.0
Wnt signaling	7.0	53.0	7.0	-0.044	0.012	1000.0	-1000.0	-0.025	-1000.0
IL6-mediated signaling events	7.0	554.0	75.0	-0.266	0.055	1000.0	-1000.0	-0.102	-1000.0
IL12-mediated signaling events	6.0	574.0	87.0	-0.194	0.023	1000.0	-1000.0	-0.14	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	193.0	28.0	-0.155	0.012	1000.0	-1000.0	-0.065	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	332.0	54.0	-0.251	0.026	1000.0	-1000.0	-0.102	-1000.0
Ephrin A  reverse signaling	6.0	43.0	7.0	-0.035	-0.0	1000.0	-1000.0	-0.026	-1000.0
Noncanonical Wnt signaling pathway	6.0	177.0	26.0	-0.22	0.012	1000.0	-1000.0	-0.084	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	368.0	61.0	-0.206	0.093	1000.0	-1000.0	-0.074	-1000.0
Reelin signaling pathway	6.0	364.0	56.0	-0.193	0.012	1000.0	-1000.0	-0.092	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	211.0	31.0	-0.159	0.016	1000.0	-1000.0	-0.094	-1000.0
Plasma membrane estrogen receptor signaling	6.0	553.0	86.0	-0.155	0.028	1000.0	-1000.0	-0.083	-1000.0
Visual signal transduction: Rods	6.0	316.0	52.0	-0.226	0.012	1000.0	-1000.0	-0.091	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	743.0	136.0	-0.603	0.065	1000.0	-1000.0	-0.077	-1000.0
Syndecan-2-mediated signaling events	5.0	359.0	69.0	-0.544	0.042	1000.0	-1000.0	-0.059	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	264.0	52.0	-0.356	0.059	1000.0	-1000.0	-0.064	-1000.0
Syndecan-3-mediated signaling events	5.0	182.0	35.0	-0.192	0.012	1000.0	-1000.0	-0.07	-1000.0
Regulation of Telomerase	5.0	563.0	102.0	-0.756	0.044	1000.0	-1000.0	-0.118	-1000.0
IL23-mediated signaling events	5.0	351.0	60.0	-0.13	0.024	1000.0	-1000.0	-0.153	-1000.0
S1P3 pathway	5.0	236.0	42.0	-0.155	0.017	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling in keratinocytes	5.0	215.0	43.0	-0.296	0.035	1000.0	-1000.0	-0.069	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.012	-1000.0
Regulation of Androgen receptor activity	5.0	400.0	70.0	-0.895	0.029	1000.0	-1000.0	-0.065	-1000.0
Caspase cascade in apoptosis	4.0	312.0	74.0	-0.407	0.039	1000.0	-1000.0	-0.06	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	-0.014	0.008	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	4.0	173.0	38.0	-0.128	0.039	1000.0	-1000.0	-0.111	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	415.0	97.0	-0.145	0.031	1000.0	-1000.0	-0.087	-1000.0
Ceramide signaling pathway	4.0	337.0	76.0	-0.756	0.252	1000.0	-1000.0	-0.072	-1000.0
S1P5 pathway	4.0	82.0	17.0	-0.059	0.03	1000.0	-1000.0	-0.053	-1000.0
EPHB forward signaling	4.0	368.0	85.0	-0.161	0.06	1000.0	-1000.0	-0.093	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	364.0	76.0	-0.069	0.029	1000.0	-1000.0	-0.085	-1000.0
IL2 signaling events mediated by STAT5	4.0	94.0	22.0	-0.055	0.041	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	4.0	467.0	99.0	-0.097	0.027	1000.0	-1000.0	-0.093	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	164.0	33.0	-0.258	0.036	1000.0	-1000.0	-0.069	-1000.0
PDGFR-beta signaling pathway	4.0	407.0	97.0	-0.132	0.047	1000.0	-1000.0	-0.089	-1000.0
BARD1 signaling events	3.0	195.0	57.0	-0.122	0.027	1000.0	-1000.0	-0.07	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	67.0	17.0	-0.045	0.027	1000.0	-1000.0	-0.056	-1000.0
PLK1 signaling events	3.0	285.0	85.0	-0.122	0.021	1000.0	-1000.0	-0.059	-1000.0
Insulin-mediated glucose transport	3.0	120.0	32.0	-0.141	0.067	1000.0	-1000.0	-0.068	-1000.0
IFN-gamma pathway	3.0	216.0	68.0	-0.419	0.065	1000.0	-1000.0	-0.088	-1000.0
IL1-mediated signaling events	3.0	210.0	62.0	-0.16	0.06	1000.0	-1000.0	-0.102	-1000.0
IL2 signaling events mediated by PI3K	3.0	197.0	58.0	-0.061	0.057	1000.0	-1000.0	-0.088	-1000.0
Canonical Wnt signaling pathway	3.0	153.0	51.0	-0.205	0.1	1000.0	-1000.0	-0.062	-1000.0
Regulation of p38-alpha and p38-beta	3.0	163.0	54.0	-0.177	0.06	1000.0	-1000.0	-0.061	-1000.0
TCGA08_rtk_signaling	3.0	86.0	26.0	-0.269	0.03	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by PRL	3.0	106.0	34.0	-0.034	0.022	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	60.0	17.0	-0.013	0.027	1000.0	-1000.0	-0.053	-1000.0
Cellular roles of Anthrax toxin	2.0	79.0	39.0	-0.191	0.019	1000.0	-1000.0	-0.029	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	229.0	85.0	-0.128	0.042	1000.0	-1000.0	-0.068	-1000.0
Nectin adhesion pathway	2.0	181.0	63.0	-0.122	0.05	1000.0	-1000.0	-0.075	-1000.0
Ephrin B reverse signaling	2.0	104.0	48.0	-0.072	0.047	1000.0	-1000.0	-0.066	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	208.0	83.0	-0.287	0.049	1000.0	-1000.0	-0.082	-1000.0
FAS signaling pathway (CD95)	2.0	94.0	47.0	-0.109	0.022	1000.0	-1000.0	-0.062	-1000.0
LPA receptor mediated events	2.0	290.0	102.0	-0.128	0.034	1000.0	-1000.0	-0.098	-1000.0
Class I PI3K signaling events	2.0	170.0	73.0	-0.06	0.027	1000.0	-1000.0	-0.08	-1000.0
Arf6 trafficking events	2.0	160.0	71.0	-0.373	0.042	1000.0	-1000.0	-0.076	-1000.0
IGF1 pathway	2.0	139.0	57.0	-0.037	0.042	1000.0	-1000.0	-0.098	-1000.0
S1P4 pathway	2.0	68.0	25.0	-0.059	0.027	1000.0	-1000.0	-0.054	-1000.0
ErbB2/ErbB3 signaling events	1.0	114.0	65.0	-0.13	0.032	1000.0	-1000.0	-0.07	-1000.0
Signaling events mediated by HDAC Class II	1.0	103.0	75.0	-0.161	0.038	1000.0	-1000.0	-0.073	-1000.0
Visual signal transduction: Cones	1.0	52.0	38.0	-0.02	0.012	1000.0	-1000.0	-0.063	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	71.0	65.0	-0.059	0.066	1000.0	-1000.0	-0.067	-1000.0
Aurora A signaling	1.0	111.0	60.0	-0.143	0.035	1000.0	-1000.0	-0.061	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	73.0	68.0	-0.141	0.049	1000.0	-1000.0	-0.067	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	39.0	37.0	-0.037	0.036	1000.0	-1000.0	-0.058	-1000.0
HIF-2-alpha transcription factor network	1.0	74.0	43.0	-0.216	0.132	1000.0	-1000.0	-0.086	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	20.0	15.0	-0.004	0.025	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	1.0	93.0	58.0	-0.064	0.033	1000.0	-1000.0	-0.079	-1000.0
Insulin Pathway	1.0	93.0	74.0	-0.042	0.035	1000.0	-1000.0	-0.098	-1000.0
VEGFR1 specific signals	1.0	87.0	56.0	-0.014	0.045	1000.0	-1000.0	-0.072	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.008	0.046	1000.0	-1000.0	-0.076	-1000.0
Canonical NF-kappaB pathway	0.0	23.0	39.0	-0.016	0.079	1000.0	-1000.0	-0.076	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.012	0.039	1000.0	-1000.0	-0.067	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.012	1000.0	-1000.0	-0.04	-1000.0
Arf6 downstream pathway	0.0	3.0	43.0	-0.023	0.023	1000.0	-1000.0	-0.042	-1000.0
EPO signaling pathway	0.0	41.0	55.0	-0.044	0.077	1000.0	-1000.0	-0.093	-1000.0
mTOR signaling pathway	0.0	30.0	53.0	-0.007	0.029	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class III	0.0	18.0	40.0	-0.02	0.022	1000.0	-1000.0	-0.047	-1000.0
TRAIL signaling pathway	0.0	33.0	48.0	-0.018	0.045	1000.0	-1000.0	-0.073	-1000.0
ceramide signaling pathway	0.0	26.0	49.0	-0.014	0.047	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by HDAC Class I	0.0	100.0	104.0	-0.161	0.055	1000.0	-1000.0	-0.071	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	15.0	36.0	-0.02	0.022	1000.0	-1000.0	-0.076	-1000.0
Atypical NF-kappaB pathway	0.0	10.0	31.0	-0.001	0.046	1000.0	-1000.0	-0.052	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	37.0	45.0	-0.029	0.06	1000.0	-1000.0	-0.104	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.003	0.029	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.004	0.012	1000.0	-1000.0	-0.042	-1000.0
p38 MAPK signaling pathway	0.0	35.0	44.0	-0.042	0.041	1000.0	-1000.0	-0.072	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.008	0.031	1000.0	-1000.0	-0.044	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.012	1000.0	-1000.0	-0.053	-1000.0
Total	1014	59160	7203	-33.2335324733	-1993.86375277	131000	-131000	-9.64111300565	-131000