E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.032 0.159 -9999.0 0.0 -0.528 14.0 14.0 KLHL20 0.01 0.086 0.19 2.0 -0.231 2.0 4.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.007 0.118 0.359 2.0 -0.336 12.0 14.0 ENAH -0.033 0.16 -9999.0 0.0 -0.526 14.0 14.0 AP1M1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.001 0.084 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.018 0.043 -9999.0 0.0 -0.171 1.0 1.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.019 0.13 -9999.0 0.0 -0.405 13.0 13.0 RAPGEF1 -0.024 0.142 -9999.0 0.0 -0.459 13.0 13.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.028 0.166 -9999.0 0.0 -0.541 14.0 14.0 CRK -0.033 0.146 -9999.0 0.0 -0.486 14.0 14.0 E-cadherin/gamma catenin/alpha catenin 0.005 0.135 -9999.0 0.0 -0.426 14.0 14.0 alphaE/beta7 Integrin 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.047 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.033 0.16 -9999.0 0.0 -0.528 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.012 0.058 -9999.0 0.0 -0.211 1.0 1.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.042 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.011 0.077 -9999.0 0.0 -0.273 1.0 1.0 ARF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.011 0.149 -9999.0 0.0 -0.49 14.0 14.0 TIAM1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.017 0.126 -9999.0 0.0 -0.384 14.0 14.0 AKT1 -0.012 0.047 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.035 0.195 -9999.0 0.0 -0.668 14.0 14.0 RhoA/GDP 0.004 0.13 0.427 3.0 -0.336 13.0 16.0 actin cytoskeleton organization 0.016 0.073 0.197 5.0 -0.181 1.0 6.0 CDC42/GDP 0.011 0.143 0.478 5.0 -0.335 13.0 18.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.009 0.088 -9999.0 0.0 -0.291 14.0 14.0 ITGB7 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.019 0.133 -9999.0 0.0 -0.405 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.005 0.12 -9999.0 0.0 -0.381 14.0 14.0 mol:GDP -0.007 0.157 0.498 5.0 -0.39 13.0 18.0 CDC42/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.001 0.12 -9999.0 0.0 -0.344 13.0 13.0 RAC1/GTP/IQGAP1 0.029 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.022 0.066 0.21 8.0 -9999.0 0.0 8.0 NME1 0.024 0.012 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.16 -9999.0 0.0 -0.528 14.0 14.0 regulation of cell-cell adhesion -0.005 0.072 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.007 0.034 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.003 0.099 -9999.0 0.0 -0.308 12.0 12.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.028 0.127 -9999.0 0.0 -0.386 13.0 13.0 CCND1 0.019 0.062 0.186 5.0 -9999.0 0.0 5.0 VAV2 -0.044 0.21 -9999.0 0.0 -0.518 24.0 24.0 RAP1/GDP 0.007 0.109 0.267 2.0 -0.314 13.0 15.0 adherens junction assembly -0.032 0.155 -9999.0 0.0 -0.509 14.0 14.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.017 0.12 -9999.0 0.0 -0.373 13.0 13.0 E-cadherin/beta catenin -0.027 0.125 -9999.0 0.0 -0.433 14.0 14.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.033 0.16 -9999.0 0.0 -0.528 14.0 14.0 PIK3CA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.029 0.104 -9999.0 0.0 -0.328 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.005 0.138 -9999.0 0.0 -0.44 14.0 14.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.029 0.17 -9999.0 0.0 -0.554 14.0 14.0