Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.012 0.122 -9999.0 0.0 -0.381 2.0 2.0 IHH -0.05 0.236 -9999.0 0.0 -0.692 19.0 19.0 SHH Np/Cholesterol/GAS1 0.005 0.075 -9999.0 0.0 -0.364 6.0 6.0 LRPAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.005 0.074 0.362 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.019 0.152 -9999.0 0.0 -0.435 14.0 14.0 SMO -0.03 0.149 -9999.0 0.0 -0.456 14.0 14.0 AKT1 -0.022 0.146 -9999.0 0.0 -0.636 5.0 5.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.029 0.147 -9999.0 0.0 -0.449 14.0 14.0 STIL 0.008 0.128 0.256 1.0 -0.312 13.0 14.0 DHH N/PTCH2 0.009 0.118 -9999.0 0.0 -0.503 8.0 8.0 DHH N/PTCH1 -0.026 0.159 -9999.0 0.0 -0.379 26.0 26.0 PIK3CA 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.012 0.151 -9999.0 0.0 -0.668 8.0 8.0 PTHLH -0.025 0.15 -9999.0 0.0 -0.474 2.0 2.0 determination of left/right symmetry -0.029 0.147 -9999.0 0.0 -0.449 14.0 14.0 PIK3R1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.025 0.149 -9999.0 0.0 -0.471 2.0 2.0 IHH N/Hhip -0.046 0.194 -9999.0 0.0 -0.475 27.0 27.0 DHH N/Hhip -0.016 0.173 -9999.0 0.0 -0.561 14.0 14.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.029 0.147 -9999.0 0.0 -0.449 14.0 14.0 pancreas development -0.013 0.15 -9999.0 0.0 -0.667 8.0 8.0 HHAT 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.108 -9999.0 0.0 -0.668 4.0 4.0 somite specification -0.029 0.147 -9999.0 0.0 -0.449 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.016 0.108 -9999.0 0.0 -0.317 17.0 17.0 SHH Np/Cholesterol/PTCH2 0.014 0.048 -9999.0 0.0 -0.394 2.0 2.0 SHH Np/Cholesterol/Megalin -0.041 0.154 -9999.0 0.0 -0.42 22.0 22.0 SHH 0.003 0.058 -9999.0 0.0 -0.507 2.0 2.0 catabolic process -0.019 0.139 -9999.0 0.0 -0.396 19.0 19.0 SMO/Vitamin D3 -0.019 0.129 -9999.0 0.0 -0.393 14.0 14.0 SHH Np/Cholesterol/Hhip -0.007 0.099 -9999.0 0.0 -0.385 10.0 10.0 LRP2 -0.064 0.234 -9999.0 0.0 -0.668 21.0 21.0 receptor-mediated endocytosis -0.06 0.191 -9999.0 0.0 -0.639 11.0 11.0 SHH Np/Cholesterol/BOC 0.014 0.049 -9999.0 0.0 -0.403 2.0 2.0 SHH Np/Cholesterol/CDO 0.013 0.049 -9999.0 0.0 -0.403 2.0 2.0 mesenchymal cell differentiation 0.007 0.099 0.383 10.0 -9999.0 0.0 10.0 mol:Vitamin D3 0.014 0.134 -9999.0 0.0 -0.327 13.0 13.0 IHH N/PTCH2 -0.016 0.157 -9999.0 0.0 -0.443 19.0 19.0 CDON 0.024 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.012 0.143 -9999.0 0.0 -0.401 19.0 19.0 Megalin/LRPAP1 -0.032 0.182 -9999.0 0.0 -0.503 21.0 21.0 PTCH2 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.006 0.046 -9999.0 0.0 -0.401 2.0 2.0 PTCH1 -0.019 0.139 -9999.0 0.0 -0.398 19.0 19.0 HHIP -0.013 0.151 -9999.0 0.0 -0.668 8.0 8.0