Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.005 0.088 -9999.0 0.0 -0.289 14.0 14.0 epithelial cell differentiation 0.013 0.123 -9999.0 0.0 -0.38 14.0 14.0 CYFIP2 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.01 0.124 0.424 6.0 -9999.0 0.0 6.0 EGFR 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EPHA2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.023 0.124 0.348 3.0 -0.367 14.0 17.0 CTNNB1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.016 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.067 0.184 -9999.0 0.0 -0.586 14.0 14.0 CTNND1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.023 0.122 0.345 3.0 -0.362 14.0 17.0 regulation of calcium-dependent cell-cell adhesion -0.045 0.144 0.345 3.0 -0.379 20.0 23.0 EGF -0.571 0.23 -9999.0 0.0 -0.655 141.0 141.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.175 0.272 -9999.0 0.0 -0.582 45.0 45.0 cortical microtubule organization 0.013 0.123 -9999.0 0.0 -0.38 14.0 14.0 GO:0000145 -0.022 0.117 0.334 3.0 -0.345 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.017 0.125 -9999.0 0.0 -0.384 14.0 14.0 MLLT4 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.041 0.086 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.027 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.018 0.104 -9999.0 0.0 -0.34 13.0 13.0 PVRL2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.028 0.11 -9999.0 0.0 -0.367 13.0 13.0 ARF6/GTP 0.061 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.035 0.195 -9999.0 0.0 -0.668 14.0 14.0 EGFR/EGFR/EGF/EGF -0.293 0.175 -9999.0 0.0 -0.399 103.0 103.0 RhoA/GDP 0.015 0.119 -9999.0 0.0 -0.363 14.0 14.0 actin cytoskeleton organization -0.023 0.119 0.332 3.0 -0.355 14.0 17.0 IGF-1R heterotetramer 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.009 0.108 -9999.0 0.0 -0.668 4.0 4.0 DIAPH1 0.03 0.105 -9999.0 0.0 -0.539 1.0 1.0 Wnt receptor signaling pathway -0.013 0.123 0.38 14.0 -9999.0 0.0 14.0 RHOA 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.041 0.088 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.024 0.121 0.335 3.0 -0.364 14.0 17.0 EFNA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.029 0.11 0.341 1.0 -0.351 14.0 15.0 Ephrin A1/EPHA2 0.008 0.114 -9999.0 0.0 -0.356 14.0 14.0 SEC6/SEC8 -0.039 0.092 -9999.0 0.0 -0.344 13.0 13.0 MGAT3 -0.046 0.147 0.348 3.0 -0.385 20.0 23.0 HGF/MET -0.004 0.127 -9999.0 0.0 -0.381 15.0 15.0 HGF 0.005 0.108 -9999.0 0.0 -0.668 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.005 0.089 -9999.0 0.0 -0.291 14.0 14.0 actin cable formation 0.022 0.146 0.497 8.0 -9999.0 0.0 8.0 KIAA1543 -0.024 0.122 0.336 3.0 -0.35 15.0 18.0 KIFC3 -0.037 0.105 -9999.0 0.0 -0.367 14.0 14.0 NCK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.022 0.125 0.348 3.0 -0.365 14.0 17.0 NCK1/GIT1 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.013 0.123 -9999.0 0.0 -0.38 14.0 14.0 EXOC4 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.104 -9999.0 0.0 -0.367 14.0 14.0 PIP5K1C -0.023 0.124 0.348 3.0 -0.367 14.0 17.0 LIMA1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.143 0.427 8.0 -9999.0 0.0 8.0 adherens junction assembly -0.003 0.131 0.368 6.0 -9999.0 0.0 6.0 IGF-1R heterotetramer/IGF1 -0.001 0.128 -9999.0 0.0 -0.359 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.02 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.025 0.128 0.348 3.0 -0.367 15.0 18.0 mol:GTP 0.055 0.026 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.01 0.119 0.329 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.005 0.088 -9999.0 0.0 -0.289 14.0 14.0 regulation of cell-cell adhesion -0.023 0.119 0.332 3.0 -0.355 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.005 0.089 -9999.0 0.0 -0.291 14.0 14.0