Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Nephrin/Neph1 signaling in the kidney podocyte	73.0	2495.0	34.0	-0.489	0.026	1000.0	-1000.0	-0.036	-1000.0
FOXA2 and FOXA3 transcription factor networks	52.0	2427.0	46.0	-1.153	0.029	1000.0	-1000.0	-0.072	-1000.0
EGFR-dependent Endothelin signaling events	49.0	1036.0	21.0	-0.571	0.036	1000.0	-1000.0	-0.044	-1000.0
Angiopoietin receptor Tie2-mediated signaling	47.0	4171.0	88.0	-0.818	0.09	1000.0	-1000.0	-0.067	-1000.0
PDGFR-alpha signaling pathway	31.0	1374.0	44.0	-0.256	0.036	1000.0	-1000.0	-0.047	-1000.0
Thromboxane A2 receptor signaling	25.0	2723.0	105.0	-0.571	0.087	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	23.0	1130.0	48.0	-0.364	0.049	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-alpha and p38-beta	19.0	847.0	44.0	-0.135	0.026	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	18.0	1470.0	78.0	-0.257	0.067	1000.0	-1000.0	-0.05	-1000.0
BMP receptor signaling	17.0	1394.0	81.0	-0.366	0.052	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	16.0	1039.0	62.0	-0.571	0.057	1000.0	-1000.0	-0.038	-1000.0
Endothelins	16.0	1616.0	96.0	-0.598	0.041	1000.0	-1000.0	-0.055	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	16.0	2012.0	125.0	-0.137	0.059	1000.0	-1000.0	-0.053	-1000.0
IL4-mediated signaling events	13.0	1205.0	91.0	-0.84	0.439	1000.0	-1000.0	-0.114	-1000.0
Integrins in angiogenesis	13.0	1119.0	84.0	-0.425	0.057	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by PTP1B	12.0	973.0	76.0	-0.574	0.085	1000.0	-1000.0	-0.044	-1000.0
amb2 Integrin signaling	11.0	971.0	82.0	-0.419	0.048	1000.0	-1000.0	-0.04	-1000.0
Ceramide signaling pathway	11.0	910.0	76.0	-0.571	0.201	1000.0	-1000.0	-0.04	-1000.0
S1P1 pathway	11.0	426.0	36.0	-0.126	0.026	1000.0	-1000.0	-0.047	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	11.0	842.0	74.0	-0.571	0.061	1000.0	-1000.0	-0.078	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	11.0	1423.0	120.0	-0.253	0.116	1000.0	-1000.0	-0.047	-1000.0
FoxO family signaling	10.0	665.0	64.0	-0.926	0.063	1000.0	-1000.0	-0.054	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	712.0	68.0	-0.457	0.074	1000.0	-1000.0	-0.113	-1000.0
Signaling events mediated by the Hedgehog family	9.0	468.0	52.0	-0.064	0.038	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in keratinocytes	9.0	388.0	43.0	-0.215	0.034	1000.0	-1000.0	-0.042	-1000.0
Glucocorticoid receptor regulatory network	8.0	914.0	114.0	-0.509	0.122	1000.0	-1000.0	-0.051	-1000.0
E-cadherin signaling events	8.0	42.0	5.0	-0.035	0.026	1000.0	-1000.0	0.0	-1000.0
LPA4-mediated signaling events	7.0	86.0	12.0	-0.14	0.007	1000.0	-1000.0	-0.03	-1000.0
Noncanonical Wnt signaling pathway	7.0	189.0	26.0	-0.173	0.026	1000.0	-1000.0	-0.05	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	598.0	82.0	-0.066	0.027	1000.0	-1000.0	-0.065	-1000.0
Syndecan-3-mediated signaling events	7.0	255.0	35.0	-0.117	0.069	1000.0	-1000.0	-0.029	-1000.0
Nongenotropic Androgen signaling	7.0	399.0	52.0	-0.118	0.051	1000.0	-1000.0	-0.038	-1000.0
Plasma membrane estrogen receptor signaling	7.0	684.0	86.0	-0.109	0.047	1000.0	-1000.0	-0.056	-1000.0
Caspase cascade in apoptosis	6.0	493.0	74.0	-0.413	0.066	1000.0	-1000.0	-0.044	-1000.0
Coregulation of Androgen receptor activity	6.0	458.0	76.0	-0.687	0.048	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	6.0	419.0	69.0	-0.282	0.087	1000.0	-1000.0	-0.051	-1000.0
p75(NTR)-mediated signaling	6.0	754.0	125.0	-0.402	0.069	1000.0	-1000.0	-0.08	-1000.0
TCR signaling in naïve CD8+ T cells	6.0	644.0	93.0	-0.219	0.115	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	467.0	76.0	-0.044	0.047	1000.0	-1000.0	-0.061	-1000.0
IL23-mediated signaling events	6.0	377.0	60.0	-0.049	0.05	1000.0	-1000.0	-0.081	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	693.0	136.0	-0.454	0.093	1000.0	-1000.0	-0.044	-1000.0
Ephrin A  reverse signaling	5.0	35.0	7.0	-0.021	0.009	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	339.0	61.0	-0.142	0.077	1000.0	-1000.0	-0.043	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	264.0	52.0	-0.254	0.079	1000.0	-1000.0	-0.032	-1000.0
TCGA08_rtk_signaling	5.0	147.0	26.0	-0.195	0.061	1000.0	-1000.0	-0.007	-1000.0
IL6-mediated signaling events	5.0	400.0	75.0	-0.217	0.039	1000.0	-1000.0	-0.051	-1000.0
S1P3 pathway	5.0	238.0	42.0	-0.107	0.035	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Rods	5.0	260.0	52.0	-0.16	0.053	1000.0	-1000.0	-0.049	-1000.0
Regulation of Androgen receptor activity	5.0	353.0	70.0	-0.802	0.042	1000.0	-1000.0	-0.049	-1000.0
Osteopontin-mediated events	4.0	161.0	38.0	-0.079	0.051	1000.0	-1000.0	-0.043	-1000.0
HIF-1-alpha transcription factor network	4.0	372.0	76.0	-0.102	0.116	1000.0	-1000.0	-0.068	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	418.0	85.0	-0.123	0.103	1000.0	-1000.0	-0.043	-1000.0
Reelin signaling pathway	4.0	278.0	56.0	-0.113	0.064	1000.0	-1000.0	-0.052	-1000.0
ceramide signaling pathway	4.0	213.0	49.0	-0.0	0.043	1000.0	-1000.0	-0.042	-1000.0
EPHB forward signaling	4.0	386.0	85.0	-0.104	0.066	1000.0	-1000.0	-0.074	-1000.0
Effects of Botulinum toxin	4.0	122.0	26.0	-0.17	0.047	1000.0	-1000.0	-0.014	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	148.0	31.0	-0.092	0.027	1000.0	-1000.0	-0.04	-1000.0
IL27-mediated signaling events	4.0	254.0	51.0	-0.931	0.236	1000.0	-1000.0	-0.055	-1000.0
Regulation of Telomerase	4.0	478.0	102.0	-0.571	0.067	1000.0	-1000.0	-0.049	-1000.0
Syndecan-4-mediated signaling events	4.0	305.0	67.0	-0.392	0.109	1000.0	-1000.0	-0.046	-1000.0
PDGFR-beta signaling pathway	4.0	470.0	97.0	-0.036	0.058	1000.0	-1000.0	-0.068	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	68.0	17.0	-0.01	0.04	1000.0	-1000.0	-0.028	-1000.0
Syndecan-1-mediated signaling events	3.0	130.0	34.0	-0.034	0.027	1000.0	-1000.0	-0.053	-1000.0
Sphingosine 1-phosphate (S1P) pathway	3.0	110.0	28.0	-0.107	0.046	1000.0	-1000.0	-0.024	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	183.0	54.0	-0.038	0.045	1000.0	-1000.0	-0.058	-1000.0
Syndecan-2-mediated signaling events	3.0	216.0	69.0	-0.419	0.053	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	3.0	136.0	39.0	-0.138	0.034	1000.0	-1000.0	-0.028	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	325.0	97.0	-0.079	0.057	1000.0	-1000.0	-0.068	-1000.0
PLK1 signaling events	3.0	266.0	85.0	-0.005	0.055	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	3.0	269.0	68.0	-0.318	0.066	1000.0	-1000.0	-0.06	-1000.0
S1P5 pathway	3.0	56.0	17.0	-0.015	0.026	1000.0	-1000.0	-0.02	-1000.0
Ephrin B reverse signaling	3.0	176.0	48.0	-0.036	0.039	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	3.0	24.0	7.0	-0.025	0.026	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	56.0	15.0	-0.01	0.027	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	3.0	157.0	51.0	-0.141	0.068	1000.0	-1000.0	-0.064	-1000.0
Regulation of p38-alpha and p38-beta	3.0	190.0	54.0	-0.124	0.065	1000.0	-1000.0	-0.049	-1000.0
Arf6 trafficking events	3.0	253.0	71.0	-0.266	0.044	1000.0	-1000.0	-0.038	-1000.0
BCR signaling pathway	3.0	367.0	99.0	-0.056	0.057	1000.0	-1000.0	-0.06	-1000.0
ErbB2/ErbB3 signaling events	2.0	184.0	65.0	-0.053	0.05	1000.0	-1000.0	-0.056	-1000.0
mTOR signaling pathway	2.0	106.0	53.0	-0.017	0.046	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	2.0	162.0	68.0	-0.02	0.053	1000.0	-1000.0	-0.036	-1000.0
Nectin adhesion pathway	2.0	141.0	63.0	-0.035	0.055	1000.0	-1000.0	-0.052	-1000.0
IL1-mediated signaling events	2.0	153.0	62.0	-0.104	0.071	1000.0	-1000.0	-0.055	-1000.0
HIF-2-alpha transcription factor network	2.0	97.0	43.0	-0.18	0.091	1000.0	-1000.0	-0.055	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	200.0	83.0	-0.244	0.045	1000.0	-1000.0	-0.044	-1000.0
Wnt signaling	2.0	20.0	7.0	-0.007	0.026	1000.0	-1000.0	-0.023	-1000.0
LPA receptor mediated events	2.0	304.0	102.0	-0.079	0.054	1000.0	-1000.0	-0.058	-1000.0
IGF1 pathway	2.0	156.0	57.0	-0.018	0.06	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.016	0.016	1000.0	-1000.0	-0.001	-1000.0
S1P4 pathway	2.0	69.0	25.0	-0.015	0.051	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by HDAC Class II	1.0	86.0	75.0	-0.104	0.065	1000.0	-1000.0	-0.036	-1000.0
IL12-mediated signaling events	1.0	136.0	87.0	-0.186	0.063	1000.0	-1000.0	-0.086	-1000.0
BARD1 signaling events	1.0	100.0	57.0	-0.045	0.058	1000.0	-1000.0	-0.048	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	117.0	65.0	-0.015	0.063	1000.0	-1000.0	-0.049	-1000.0
Arf6 downstream pathway	1.0	62.0	43.0	-0.042	0.043	1000.0	-1000.0	-0.033	-1000.0
EPO signaling pathway	1.0	73.0	55.0	-0.011	0.067	1000.0	-1000.0	-0.047	-1000.0
Insulin-mediated glucose transport	1.0	33.0	32.0	-0.011	0.045	1000.0	-1000.0	-0.027	-1000.0
FAS signaling pathway (CD95)	1.0	76.0	47.0	-0.11	0.039	1000.0	-1000.0	-0.046	-1000.0
Retinoic acid receptors-mediated signaling	1.0	90.0	58.0	-0.034	0.055	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by PI3K	1.0	86.0	58.0	-0.014	0.061	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	1.0	129.0	73.0	-0.018	0.043	1000.0	-1000.0	-0.047	-1000.0
TCGA08_retinoblastoma	1.0	9.0	8.0	-0.038	0.029	1000.0	-1000.0	-0.007	-1000.0
Insulin Pathway	1.0	112.0	74.0	-0.017	0.067	1000.0	-1000.0	-0.052	-1000.0
VEGFR1 specific signals	1.0	82.0	56.0	-0.016	0.055	1000.0	-1000.0	-0.058	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	46.0	33.0	-0.038	0.062	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by PRL	1.0	67.0	34.0	-0.044	0.038	1000.0	-1000.0	-0.056	-1000.0
FOXM1 transcription factor network	1.0	77.0	51.0	-0.066	0.073	1000.0	-1000.0	-0.096	-1000.0
Aurora B signaling	1.0	116.0	67.0	-0.203	0.08	1000.0	-1000.0	-0.04	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	15.0	23.0	-0.014	0.046	1000.0	-1000.0	-0.039	-1000.0
Canonical NF-kappaB pathway	0.0	7.0	39.0	-0.0	0.061	1000.0	-1000.0	-0.043	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.008	0.024	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Cones	0.0	24.0	38.0	-0.015	0.05	1000.0	-1000.0	-0.014	-1000.0
Circadian rhythm pathway	0.0	5.0	22.0	-0.009	0.052	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	14.0	17.0	0.012	0.052	1000.0	-1000.0	-0.036	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.026	0.038	1000.0	-1000.0	-0.002	-1000.0
Aurora A signaling	0.0	15.0	60.0	-0.009	0.059	1000.0	-1000.0	-0.027	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.012	0.047	1000.0	-1000.0	-0.016	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	5.0	37.0	-0.006	0.062	1000.0	-1000.0	-0.043	-1000.0
Signaling events mediated by HDAC Class III	0.0	15.0	40.0	-0.047	0.048	1000.0	-1000.0	-0.024	-1000.0
TRAIL signaling pathway	0.0	6.0	48.0	-0.0	0.068	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class I	0.0	83.0	104.0	-0.104	0.064	1000.0	-1000.0	-0.047	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	0.0	36.0	-0.052	0.054	1000.0	-1000.0	-0.045	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.0	0.038	1000.0	-1000.0	-0.027	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	36.0	45.0	0.001	0.072	1000.0	-1000.0	-0.053	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.001	0.022	1000.0	-1000.0	0.0	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	1.0	27.0	-0.0	0.061	1000.0	-1000.0	-0.043	-1000.0
IL2 signaling events mediated by STAT5	0.0	7.0	22.0	-0.003	0.037	1000.0	-1000.0	-0.043	-1000.0
Rapid glucocorticoid signaling	0.0	4.0	20.0	-0.004	0.032	1000.0	-1000.0	-0.01	-1000.0
p38 MAPK signaling pathway	0.0	26.0	44.0	-0.0	0.048	1000.0	-1000.0	-0.028	-1000.0
Arf1 pathway	0.0	14.0	54.0	-0.001	0.051	1000.0	-1000.0	-0.024	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	820	53312	7203	-24.0055804889	7.77851341005	131000	-131000	-5.66405515224	-131000