HotNet pathway analysis of mutation and copy number data
Brain Lower Grade Glioma (Primary solid tumor)
15 January 2014
|
analyses__2014_01_15
Maintainer Information
Citation Information
Maintained by Hailei Zhang
(Broad Institute)
Cite as
Broad Institute TCGA Genome Data Analysis Center
(2014):
HotNet pathway analysis of mutation and copy number data.
Broad Institute of MIT and Harvard.
doi:10.7908/C1XW4H95
Overview
Introduction
Summary
There were 7 significant subnetworks identified in HotNet analysis.
Results
Significant subnetworks
HotNet identifies 7 altered subnetworks based on the matched somatic mutation and copy number alterations data. Table 1 showes the top 10 significant subnetworks.
Table 1. Get Full Table Top 10 out of 7 subnetworks in ranked by p value. The last column of RepeatTimes shows how many times the subnetwork was picked up in differenct delta values.
| Network | No.ofgenes | p-value | RepeatTimes |
|---|---|---|---|
| BCAN(28),ADAMTS4(27),SERPINA3(70),MST1(3) | 4 | 0.041 | 1 |
| KCNJ2(21),ADRB2(40),HTR4(40),AKAP5(70) | 4 | 0.041 | 1 |
| MET(99),ARHGEF12(49),PLXNB1(1),MLL(52) | 4 | 0.041 | 1 |
| RERE(114),TRIP6(98),FBLN1(48),ECM1(28) | 4 | 0.041 | 1 |
| SGCD(40),ADRA1B(40),KCND2(97),FLNC(99) | 4 | 0.041 | 1 |
| CDH9(32),CDH18(32),CDH12(34),CDH10(32),CDH6(31) | 5 | 0.000 | 1 |
| HDAC4(43),CYFIP2(40),FXR1(15),REV3L(51),ATRX(140),LUC7L2(97) | 6 | 0.000 | 1 |
Methods & Data
Copyright © 2014
Broad Institute TCGA GDAC as part of the TCGA Research Network.
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