Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.022 0.086 -9999.0 0.0 -0.357 9.0 9.0 epithelial cell differentiation -0.031 0.121 -9999.0 0.0 -0.504 9.0 9.0 CYFIP2 -0.053 0.207 -9999.0 0.0 -0.865 9.0 9.0 ENAH 0.011 0.127 -9999.0 0.0 -0.511 4.0 4.0 EGFR -0.024 0.141 -9999.0 0.0 -0.865 4.0 4.0 EPHA2 -0.047 0.196 -9999.0 0.0 -0.865 8.0 8.0 MYO6 -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.036 0.14 -9999.0 0.0 -0.586 9.0 9.0 AQP5 -0.024 0.1 -9999.0 0.0 -0.422 8.0 8.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.029 0.113 -9999.0 0.0 -0.472 9.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.018 0.135 -9999.0 0.0 -0.473 10.0 10.0 EGF 0.094 0.158 0.362 38.0 -9999.0 0.0 38.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.077 0.2 -9999.0 0.0 -0.562 20.0 20.0 cortical microtubule organization -0.031 0.121 -9999.0 0.0 -0.504 9.0 9.0 GO:0000145 -0.028 0.108 -9999.0 0.0 -0.45 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.031 0.122 -9999.0 0.0 -0.511 9.0 9.0 MLLT4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.163 -9999.0 0.0 -0.788 4.0 4.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.037 0.135 -9999.0 0.0 -0.537 10.0 10.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.027 0.107 -9999.0 0.0 -0.446 9.0 9.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 ARF6/GTP -0.034 0.125 -9999.0 0.0 -0.496 10.0 10.0 CDH1 -0.053 0.207 -9999.0 0.0 -0.865 9.0 9.0 EGFR/EGFR/EGF/EGF -0.01 0.166 -9999.0 0.0 -0.537 11.0 11.0 RhoA/GDP -0.029 0.114 -9999.0 0.0 -0.475 9.0 9.0 actin cytoskeleton organization -0.028 0.109 -9999.0 0.0 -0.454 9.0 9.0 IGF-1R heterotetramer -0.007 0.109 0.361 2.0 -0.863 2.0 4.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.007 0.109 0.362 2.0 -0.865 2.0 4.0 IGF1 -0.329 0.42 -9999.0 0.0 -0.865 56.0 56.0 DIAPH1 -0.053 0.18 -9999.0 0.0 -0.717 10.0 10.0 Wnt receptor signaling pathway 0.031 0.121 0.504 9.0 -9999.0 0.0 9.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.163 -9999.0 0.0 -0.789 4.0 4.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.029 0.112 -9999.0 0.0 -0.466 9.0 9.0 EFNA1 -0.006 0.071 -9999.0 0.0 -0.865 1.0 1.0 LPP -0.028 0.109 -9999.0 0.0 -0.453 9.0 9.0 Ephrin A1/EPHA2 -0.057 0.186 -9999.0 0.0 -0.596 14.0 14.0 SEC6/SEC8 -0.026 0.102 -9999.0 0.0 -0.426 9.0 9.0 MGAT3 -0.019 0.137 -9999.0 0.0 -0.482 10.0 10.0 HGF/MET -0.241 0.273 -9999.0 0.0 -0.514 69.0 69.0 HGF -0.394 0.431 -9999.0 0.0 -0.865 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.022 0.086 -9999.0 0.0 -0.36 9.0 9.0 actin cable formation 0.018 0.112 -9999.0 0.0 -0.444 4.0 4.0 KIAA1543 -0.04 0.15 -9999.0 0.0 -0.539 11.0 11.0 KIFC3 -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 NCK1 -0.006 0.071 -9999.0 0.0 -0.865 1.0 1.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 NCK1/GIT1 -0.005 0.055 -9999.0 0.0 -0.672 1.0 1.0 mol:GDP -0.031 0.121 -9999.0 0.0 -0.504 9.0 9.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 PIP5K1C -0.029 0.115 -9999.0 0.0 -0.481 9.0 9.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.044 0.136 -9999.0 0.0 -0.644 4.0 4.0 adherens junction assembly 0.001 0.152 -9999.0 0.0 -0.506 11.0 11.0 IGF-1R heterotetramer/IGF1 -0.212 0.256 -9999.0 0.0 -0.495 63.0 63.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.036 0.127 -9999.0 0.0 -0.482 11.0 11.0 mol:GTP -0.036 0.134 -9999.0 0.0 -0.533 10.0 10.0 establishment of epithelial cell apical/basal polarity -0.025 0.097 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.022 0.086 -9999.0 0.0 -0.357 9.0 9.0 regulation of cell-cell adhesion -0.028 0.109 -9999.0 0.0 -0.454 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.022 0.086 -9999.0 0.0 -0.36 9.0 9.0